MCID: QFV001
MIFTS: 63

Q Fever

Categories: Infectious diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Q Fever

MalaCards integrated aliases for Q Fever:

Name: Q Fever 12 77 54 60 45 15 17 74 3
Infection Due to Coxiella Burnetii 12 60
Quadrilateral Fever 60 74
Query Fever 54 60
Coxiella Burnetii Fever 54
Pneumonia in Q Fever 74
Q Fever Pneumonia 54
Nine Mile Fever 60
Coxiellosis 60

Characteristics:

Orphanet epidemiological data:

60
q fever
Inheritance: Not applicable; Prevalence: <1/1000000 (United States),1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11100
ICD9CM 36 083.0
MeSH 45 D011778
NCIt 51 C34970
SNOMED-CT 69 86012006
ICD10 34 A78
MESH via Orphanet 46 D011778
ICD10 via Orphanet 35 A78
UMLS via Orphanet 75 C0034362 C2973787
Orphanet 60 ORPHA781

Summaries for Q Fever

NIH Rare Diseases : 54 Q fever is a worldwide disease with acute and chronic stages caused by the bacteria known as Coxiella burnetii. Cattle, sheep, and goats are the primary reservoirs although a variety of species may be infected. Organisms are excreted in birth fluids, milk, urine, and feces of infected animals and are able to survive for long periods in the environment. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and waste products of infected animals. Other modes of transmission to humans, including tick bites, ingestion of unpasteurized milk or dairy products, and human to human transmission, are rare. Humans are often very susceptible to the disease, and very few organisms may be required to cause infection. In less than 5% of cases the affected people with acute Q fever infection develop a chronic Q fever. Treatment of the acute form is made with antibiotics. The chronic form's treatment depends on the symptoms.

MalaCards based summary : Q Fever, also known as infection due to coxiella burnetii, is related to endocarditis and coccidioidomycosis, and has symptoms including fever, arthralgia and myalgia. An important gene associated with Q Fever is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Doxycycline and Tetracycline have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has material basis in Coxiella burnetii, which is transmitted by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted by ingestion of contaminated milk, transmitted by tick bites and transmitted by contact with infected person. The infection has symptom fever, has symptom headache, has symptom cough, has symptom pleuritic chest pain, has symptom myalgia and has symptom arthralgia.

Wikipedia : 77 Q fever is a disease caused by infection with Coxiella burnetii, a bacterium that affects humans and... more...

Related Diseases for Q Fever

Diseases related to Q Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 428)
# Related Disease Score Top Affiliating Genes
1 endocarditis 31.4 IL10 IL6 TLR2 TNF
2 coccidioidomycosis 30.6 IL10 TLR4
3 osteomyelitis 30.3 IFNG IL10 IL1B IL6 TNF
4 miliary tuberculosis 30.3 IFNG TNF
5 spotted fever 30.3 CCL5 IFNG IL10 TNF
6 scrub typhus 30.2 IL10 IL1B TLR2 TLR4 TNF
7 brucellosis 30.2 IFNG IL10 IL4 IL6 TLR4 TNF
8 variola major 30.2 IFNG TLR4
9 anterior uveitis 30.1 IL6 TLR4
10 hepatitis a 30.1 IFNG IL10 TNF
11 plasmodium falciparum malaria 30.1 IFNG IL10 TNF
12 adult respiratory distress syndrome 30.1 IL10 IL6 TNF
13 acute respiratory distress syndrome 30.0 IL1B IL6 TNF
14 chronic fatigue syndrome 30.0 IL10 IL1B IL6 TNF
15 prosthetic joint infection 30.0 IL1B TLR2 TLR4
16 leptospirosis 30.0 IFNG IL10 IL1B IL6 TLR2 TNF
17 pericarditis 30.0 IFNG IL1B IL6 TNF
18 crohn's disease 29.9 IL10 NOD2 TNF
19 proliferative glomerulonephritis 29.9 IFNG IL4 IL6
20 lyme disease 29.9 IL1B IL6 TLR2 TNF
21 pneumonia 29.9 CCL5 IL10 IL1B IL6 TLR2 TLR4
22 spondylitis 29.8 IL6 NOD2 TNF
23 trench fever 29.8 TLR2 TLR4 TNF
24 peritonitis 29.7 IL10 IL1B IL6 TLR2 TNF
25 campylobacteriosis 29.7 IFNG IL1B TLR4
26 neuritis 29.7 CCL5 IFNG IL1B IL4 TNF
27 yellow fever 29.7 CCL5 IL4 IL6
28 uveitis 29.6 IFNG IL10 IL4 NOD2 TNF
29 arthritis 29.6 IFNG IL10 IL1B IL6 NOD2 TNF
30 legionellosis 29.5 IL1B MYD88 TLR2 TLR4 TNF
31 pulmonary disease, chronic obstructive 29.5 CCL5 IL6 TLR2 TNF
32 kawasaki disease 29.4 IL10 IL6 MYD88 TNF
33 gastroenteritis 29.4 IL10 IL1B IL4 IL6 TNF
34 human immunodeficiency virus infectious disease 29.4 CCL5 IFNG IL10 IL6 TNF
35 temporal arteritis 29.4 CCL5 IFNG IL6 TNF
36 pertussis 29.4 IL10 IL1B IL6 TLR4 TNF
37 melioidosis 29.3 IFNG IL10 IL6 TLR2 TLR4 TNF
38 cytomegalovirus infection 29.3 CCL5 IL1B IL6 TNF
39 meningitis 29.3 IFNG IL10 IL1B IL6 TLR2 TNF
40 demyelinating disease 29.2 CCL5 IFNG IL10 IL1B TNF
41 autoimmune disease 29.2 IFNG IL10 IL1B IL4 IL6 TNF
42 lymphadenitis 29.2 IFNG IL10 IL1B NOD2 TLR4 TNF
43 echinococcosis 29.1 IFNG IL10 IL6 TLR2 TLR4 TNF
44 myocardial infarction 28.6 CCL5 IL10 IL1B IL6 TLR4 TNF
45 chlamydia 28.5 IFNG IL10 IL1B IL4 IL6 TLR2
46 toxoplasmosis 28.3 IFNG IL10 IL1B IL4 IL6 MYD88
47 rheumatoid arthritis 28.2 CCL5 IFNG IL10 IL1B IL4 IL6
48 systemic lupus erythematosus 28.2 CCL5 IFNG IL10 IL1B IL4 IL6
49 asthma 27.9 ARG1 CCL5 IFNG IL10 IL1B IL4
50 malaria 27.5 CCL5 IFNG IL10 IL1B IL4 IL6

Graphical network of the top 20 diseases related to Q Fever:



Diseases related to Q Fever

Symptoms & Phenotypes for Q Fever

Symptoms:

12
  • fever
  • arthralgia
  • myalgia
  • cough
  • headache
  • pleuritic chest pain

GenomeRNAi Phenotypes related to Q Fever according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.36 NOD2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.36 ARG1 IL10
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.36 IL10
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.36 IL10
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.36 IL10
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.36 ARG1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.36 ARG1 IL10 NOD2 TLR4

MGI Mouse Phenotypes related to Q Fever:

47 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 ARG1 CCL5 IFNG IL10 IL1B IL4
2 immune system MP:0005387 10.29 ARG1 CCL5 IFNG IL10 IL1B IL4
3 homeostasis/metabolism MP:0005376 10.26 ARG1 IFNG IL10 IL1B IL4 IL6
4 growth/size/body region MP:0005378 10.25 IFNG IL10 IL1B IL4 IL6 MYD88
5 cellular MP:0005384 10.23 IFNG IL10 IL4 IL6 MYD88 NOD2
6 digestive/alimentary MP:0005381 10.22 IFNG IL10 IL4 IL6 MYD88 NOD2
7 mortality/aging MP:0010768 10.2 ARG1 IFNG IL10 IL1B IL4 IL6
8 cardiovascular system MP:0005385 10.19 IFNG IL10 IL1B IL6 MYD88 TLR2
9 endocrine/exocrine gland MP:0005379 10.1 IFNG IL10 IL4 IL6 MYD88 TLR2
10 integument MP:0010771 10.1 IFNG IL10 IL1B IL4 IL6 TLR2
11 liver/biliary system MP:0005370 10.08 ARG1 IFNG IL10 IL4 IL6 TLR2
12 nervous system MP:0003631 10.07 ARG1 IFNG IL10 IL1B IL4 IL6
13 neoplasm MP:0002006 10.01 IFNG IL10 IL1B IL6 MYD88 TLR2
14 muscle MP:0005369 9.91 IFNG IL10 IL6 TLR2 TLR4 TNF
15 renal/urinary system MP:0005367 9.8 IFNG IL4 IL6 MYD88 TLR2 TLR4
16 reproductive system MP:0005389 9.8 IFNG IL10 IL4 IL6 MYD88 TLR4
17 respiratory system MP:0005388 9.76 IFNG IL10 IL4 IL6 MYD88 TLR2
18 skeleton MP:0005390 9.65 IFNG IL10 IL1B IL4 IL6 MYD88
19 vision/eye MP:0005391 9.17 IFNG IL10 IL4 IL6 MYD88 TLR4

Drugs & Therapeutics for Q Fever

Drugs for Q Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
3 Anti-Bacterial Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Antimalarials Phase 4
6 Antiparasitic Agents Phase 4
7 Antibiotics, Antitubercular Phase 4
8 Liver Extracts Phase 4
9 Antiprotozoal Agents Phase 4
10 Immunologic Factors Phase 2
11 Vaccines Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Qure Study: Q-fever Fatigue Syndrome - Response to Treatment Completed NCT01318356 Phase 4 Doxycycline;Placebo
2 Safety Evaluation of a Q-fever Vaccine, NDBR 105 Completed NCT00584454 Phase 2
3 Safety and Immunogenicity of Q Fever Vaccine Withdrawn NCT02092142 Phase 2
4 Q Fever and Auto-immunity Unknown status NCT02822807 Not Applicable
5 A Screening Strategy for Q Fever Among Pregnant Women Unknown status NCT01095328 Not Applicable
6 Chronic Q-fever in Patients With an Abdominal Aortic Disease (QAAD-study) Unknown status NCT01450501
7 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
8 Study on Seroprevalence and Risk Factors of Coxiella Burnetii (Q Fever) in the South of Reunion Island Completed NCT02898402
9 Prevalence and Risk Factors for Coxiella Burnetii Seropositivity (Q Fever) Among Adults in Western France Recruiting NCT03334019

Search NIH Clinical Center for Q Fever

Cochrane evidence based reviews: q fever

Genetic Tests for Q Fever

Anatomical Context for Q Fever

MalaCards organs/tissues related to Q Fever:

42
Testes, Bone, Bone Marrow, Skin, Monocytes, Heart, T Cells

Publications for Q Fever

Articles related to Q Fever:

(show top 50) (show all 2045)
# Title Authors Year
1
Chronic Q Fever with Vascular Involvement: Progressive Abdominal Pain in a Patient with Aortic Aneurysm Repair in the United States. ( 30915246 )
2019
2
Acute Q fever endocarditis: a paradigm shift following the systematic use of transthoracic echocardiography during acute Q fever. ( 30785186 )
2019
3
A systematic knowledge synthesis on the spatial dimensions of Q fever epidemics. ( 30402920 )
2019
4
Acute Q fever pneumonia: high-resolution computed tomographic findings in six patients. ( 30608178 )
2019
5
Q fever vaccination of children in Australia: Limited experience to date. ( 30604569 )
2019
6
Surveying the profession about Q fever. ( 30606864 )
2019
7
Genetic variations in innate immunity genes affect response to Coxiella burnetii and are associated with susceptibility to chronic Q fever. ( 30616015 )
2019
8
Long-term effect of cognitive behavioural therapy and doxycycline treatment for patients with Q fever fatigue syndrome: One-year follow-up of the Qure study. ( 30654996 )
2019
9
Cytokine profiles in patients with Q fever fatigue syndrome. ( 30684502 )
2019
10
Swab cloths as a tool for revealing environmental contamination by Q fever in ruminant farms. ( 30702810 )
2019
11
Acute Q-fever infection in a dairy products maker without direct animal contact. ( 30754079 )
2019
12
Q fever: more common than we think, and what this means for prevention. ( 30773646 )
2019
13
Seroprevalence of Q fever among high-risk occupations in the Ilam province, the west of Iran. ( 30779802 )
2019
14
The sero-epidemiology of Coxiella burnetii (Q fever) across livestock species and herding contexts in Laikipia County, Kenya. ( 30788910 )
2019
15
Is a One Health Approach Utilized for Q Fever Control? A Comprehensive Literature Review. ( 30823481 )
2019
16
Re: 'Chronic Q fever-related complications and mortality: data from a nationwide cohort' by Roeden et al. ( 30825675 )
2019
17
Promiscuous Coxiella burnetii CD4 Epitope Clusters Associated With Human Recall Responses Are Candidates for a Novel T-Cell Targeted Multi-Epitope Q Fever Vaccine. ( 30828331 )
2019
18
Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa. ( 30831112 )
2019
19
Characterizing Early Stages of Human Alveolar Infection by the Q Fever Agent, Coxiella burnetii. ( 30833339 )
2019
20
Seroprevalence of Q fever among metropolitan and non-metropolitan blood donors in New South Wales and Queensland, 2014-2015. ( 30848517 )
2019
21
Fever of unknown origin and Q-fever: a case series in a Bulgarian hospital. ( 30858949 )
2019
22
EpiNATO-2: Enhancing Situational Awareness and Overall Force Health Protection While Deployed in the Combined Joint NATO Environment: Describing the Identified 2016 Q Fever Outbreak in Kosovo Force (KFOR). ( 30859532 )
2019
23
Seroprevalence of Q fever in cattle, sheep and goats in the Volta region of Ghana. ( 30859744 )
2019
24
Epidemiological, clinical and laboratory characteristics of acute Q fever in an endemic area in Israel, 2006-2016. ( 30869006 )
2019
25
Disease in the dust: experiences of Q fever during drought in Australia. ( 30880602 )
2019
26
The sexual dimorphism of anticardiolipin autoantibodies in acute Q fever patients. ( 30898724 )
2019
27
Chronic Q fever-related complications and mortality: data from a nationwide cohort. ( 30910718 )
2019
28
Case Report: Scrub Typhus and Q Fever Coinfection. ( 30915946 )
2019
29
Vascular infection with outside-in vertebral destruction in chronic Q fever. ( 29856356 )
2018
30
A Nationwide Seroepidemiologic Study on Q Fever Antibodies in Sheep of Portugal. ( 29969389 )
2018
31
Q fever spondylitis: 2 cases report. ( 29887174 )
2018
32
Airborne geographical dispersal of Q fever from livestock holdings to human communities: a systematic review and critical appraisal of evidence. ( 29764368 )
2018
33
Understanding Q Fever Risk to Humans in Minnesota Through the Analysis of Spatiotemporal Trends. ( 29261435 )
2018
34
Seroprevalence of Q Fever Among the Indigenous People (Orang Asli) of Peninsular Malaysia. ( 29336685 )
2018
35
Familiarity of general practitioners with Q fever decreases hospitalisation risk. ( 29845941 )
2018
36
FISH and PNA FISH for the diagnosis of Q fever endocarditis and vascular infections. ( 29899006 )
2018
37
Willingness of veterinarians in Australia to recommend Q fever vaccination in veterinary personnel: Implications for workplace health and safety compliance. ( 29856835 )
2018
38
Vascular infection and vertebral destruction in a patient with Q fever. ( 29412972 )
2018
39
Q Fever in Military Firefighters during Cadet Training in Brazil. ( 29943714 )
2018
40
Tache Noire in a Patient with Acute Q Fever. ( 29298443 )
2018
41
Serosurveillance of Coxiellosis (Q-fever) and Brucellosis in goats in selected provinces of Lao People's Democratic Republic. ( 29649313 )
2018
42
Autoimmunity and B-cell dyscrasia in acute and chronic Q fever: A review of the literature. ( 29908707 )
2018
43
Seroprevalence of horses to Coxiella burnetii in an Q fever endemic area. ( 29426406 )
2018
44
Q fever: an under-reported reportable communicable disease. ( 29941056 )
2018
45
In this issue - June 2018: Diversity of Haemophilus parasuis isolates from Australian piggeriesa88A^a88Detection of bovine noroviruses in Australian dairy cattlea88A^a88Myocardial adenomatoid tumour in a calfa88A^a88Hypertrophic cardiomyopathy in a horse a88A^a88A history of veterinary education a88A^a88Review of Q fever notifications in Victoria. ( 29878327 )
2018
46
Outbreaks of abortions by Coxiella burnetii in small ruminant flocks and a longitudinal serological approach on archived bulk tank milk suggest Q fever emergence in Central Portugal. ( 29799172 )
2018
47
Q fever endocarditis after right ventricle to pulmonary artery conduit insertion: Case series and review of the literature. ( 29440832 )
2018
48
Farming, Q fever and public health: agricultural practices and beyond. ( 29321921 )
2018
49
The effect of measuring serum doxycycline concentrations on clinical outcomes during treatment of chronic Q fever. ( 29325142 )
2018
50
Q fever epidemic in Cayenne, French Guiana, epidemiologically linked to three-toed sloth. ( 29406281 )
2018

Variations for Q Fever

Expression for Q Fever

Search GEO for disease gene expression data for Q Fever.

Pathways for Q Fever

Pathways related to Q Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 ARG1 CCL5 IFNG IL10 IL1B IL4
2
Show member pathways
13.68 CCL5 IFNG IL10 IL1B IL4 IL6
3
Show member pathways
13.53 CCL5 IFNG IL10 IL1B IL4 IL6
4
Show member pathways
13.48 CCL5 IL10 IL1B IL4 IL6 MYD88
5
Show member pathways
13.42 CCL5 IFNG IL10 IL1B IL4 IL6
6
Show member pathways
13.29 CCL5 IL10 IL1B IL4 IL6 TNF
7
Show member pathways
13.25 IFNG IL1B IL4 MYD88 TLR2 TLR4
8
Show member pathways
13.22 CCL5 IFNG IL10 IL1B IL6 MYD88
9
Show member pathways
13.04 CCL5 IL1B IL6 MYD88 TLR2 TLR4
10
Show member pathways
12.99 IL4 IL6 TLR2 TLR4 TNF
11
Show member pathways
12.93 IFNG IL10 IL1B IL4 IL6 TNF
12
Show member pathways
12.86 CCL5 IFNG IL1B IL6 MYD88 TLR4
13
Show member pathways
12.8 IL1B IL6 MYD88 TLR2 TLR4 TNF
14
Show member pathways
12.7 CCL5 IFNG IL1B IL4 IL6 MYD88
15 12.69 CCL5 IFNG IL10 IL1B IL4 MYD88
16
Show member pathways
12.66 IL1B MYD88 TLR2 TLR4 TNF
17
Show member pathways
12.65 IFNG IL10 IL1B IL6 TNF
18
Show member pathways
12.62 IFNG IL10 IL4 TNF
19
Show member pathways
12.6 IFNG IL10 IL1B IL4 IL6 NOD2
20
Show member pathways
12.55 IFNG IL10 IL1B IL4 IL6 TNF
21
Show member pathways
12.45 CCL5 IFNG IL1B IL4 IL6 TNF
22
Show member pathways
12.45 IFNG IL1B IL4 IL6 TLR2 TNF
23
Show member pathways
12.43 IFNG IL1B IL6 MYD88 TLR4 TNF
24
Show member pathways
12.42 IFNG IL10 IL4 IL6
25
Show member pathways
12.38 IL6 MYD88 TLR2 TLR4 TNF
26
Show member pathways
12.37 IFNG IL10 IL1B IL4 IL6 TNF
27
Show member pathways
12.34 IL1B IL6 MYD88 TLR2 TNF
28
Show member pathways
12.33 IL10 IL1B IL6 MYD88 TNF
29 12.31 IFNG IL6 TLR2 TLR4 TNF
30
Show member pathways
12.31 IFNG IL10 IL1B IL4 MYD88 TLR2
31
Show member pathways
12.27 IFNG IL1B TLR4 TNF
32
Show member pathways
12.24 CCL5 IL1B MYD88 TLR2 TLR4
33 12.24 IL10 IL1B IL6 TNF
34
Show member pathways
12.21 IFNG IL10 IL1B IL6 TLR2 TLR4
35
Show member pathways
12.19 IFNG IL1B IL4 IL6 MYD88 TLR2
36
Show member pathways
12.18 CCL5 IFNG IL10 IL1B IL4 IL6
37
Show member pathways
12.18 IFNG IL1B IL4 IL6 TLR2 TLR4
38 12.16 IFNG IL10 IL1B IL6 MYD88 NOD2
39 12.14 IFNG IL10 IL4 IL6 TNF
40 12.13 IL10 IL1B IL4 IL6 TNF
41 12.13 ARG1 IFNG IL1B IL4 IL6 TLR4
42 12.11 CCL5 IL1B IL6 NOD2 TNF
43 12.09 IFNG IL1B TNF
44 12.05 IFNG IL1B TNF
45
Show member pathways
12.03 IL1B TLR2 TLR4
46 12 IL1B IL4 IL6 TNF
47
Show member pathways
11.99 IFNG IL1B IL4
48 11.99 IL1B MYD88 TLR4 TNF
49 11.97 IFNG IL1B IL6 MYD88 TLR4
50 11.96 IFNG IL1B IL6

GO Terms for Q Fever

Cellular components related to Q Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ARG1 CCL5 IFNG IL10 IL1B IL4
2 extracellular space GO:0005615 9.23 ARG1 CCL5 IFNG IL10 IL1B IL4

Biological processes related to Q Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Name GO ID Score Top Affiliating Genes
1 activation of MAPK activity GO:0000187 9.99 IL1B NOD2 TLR4 TNF
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.99 IL10 IL1B IL6 TNF
3 response to virus GO:0009615 9.98 CCL5 IFNG MYD88 TNF
4 defense response to Gram-positive bacterium GO:0050830 9.98 IL6 MYD88 TLR2 TNF
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 CCL5 NOD2 TLR4 TNF
6 response to lipopolysaccharide GO:0032496 9.97 ARG1 IL10 IL1B MYD88 TLR2 TLR4
7 cellular response to organic cyclic compound GO:0071407 9.94 CCL5 IL1B NOD2 TNF
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.94 CCL5 IFNG IL4 IL6
9 cellular response to interferon-gamma GO:0071346 9.93 CCL5 TLR2 TLR4
10 regulation of inflammatory response GO:0050727 9.93 MYD88 NOD2 TLR4 TNF
11 regulation of insulin secretion GO:0050796 9.93 CCL5 IFNG IL1B TNF
12 positive regulation of JNK cascade GO:0046330 9.93 IL1B MYD88 NOD2 TLR4 TNF
13 cellular response to mechanical stimulus GO:0071260 9.92 IL1B MYD88 TLR4
14 positive regulation of inflammatory response GO:0050729 9.92 TLR2 TLR4 TNF
15 positive regulation of T cell proliferation GO:0042102 9.92 CCL5 IL1B IL4 IL6
16 humoral immune response GO:0006959 9.91 IFNG IL6 TNF
17 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 CCL5 IL6 MYD88 TNF
18 cellular response to lipopolysaccharide GO:0071222 9.91 ARG1 IL10 IL1B IL6 NOD2 TLR4
19 immune response GO:0006955 9.91 CCL5 IFNG IL10 IL1B IL4 IL6
20 JNK cascade GO:0007254 9.9 MYD88 NOD2 TNF
21 interleukin-1-mediated signaling pathway GO:0070498 9.9 IL1B MYD88 NOD2
22 positive regulation of interferon-gamma production GO:0032729 9.89 IL1B TLR4 TNF
23 positive regulation of tumor necrosis factor production GO:0032760 9.89 MYD88 NOD2 TLR2 TLR4
24 protein kinase B signaling GO:0043491 9.88 CCL5 IL1B TNF
25 toll-like receptor signaling pathway GO:0002224 9.88 MYD88 TLR2 TLR4
26 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.88 MYD88 TLR2 TLR4
27 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 IL1B NOD2 TLR2 TLR4 TNF
28 negative regulation of interleukin-6 production GO:0032715 9.87 IL10 TLR4 TNF
29 negative regulation of neurogenesis GO:0050768 9.87 IL1B IL6 TNF
30 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 IFNG IL1B TLR4 TNF
31 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 IL1B IL6 MYD88 NOD2 TLR2 TLR4
32 positive regulation of interleukin-12 production GO:0032735 9.86 IFNG TLR2 TLR4
33 positive regulation of interleukin-10 production GO:0032733 9.85 NOD2 TLR2 TLR4
34 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.84 MYD88 NOD2 TLR4
35 positive regulation of glial cell proliferation GO:0060252 9.84 IL1B IL6 TNF
36 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.83 IFNG IL1B TNF
37 negative regulation of growth of symbiont in host GO:0044130 9.83 IL10 MYD88 TNF
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.83 IL10 IL1B TNF
39 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.82 NOD2 TLR2 TLR4
40 positive regulation of chemokine production GO:0032722 9.81 IL6 TLR2 TLR4 TNF
41 response to glucocorticoid GO:0051384 9.8 IL10 IL6 TNF
42 positive regulation of osteoclast differentiation GO:0045672 9.77 IFNG TNF
43 defense response to protozoan GO:0042832 9.77 ARG1 IL10
44 positive regulation of stress-activated MAPK cascade GO:0032874 9.77 NOD2 TLR4
45 microglial cell activation GO:0001774 9.76 TLR2 TNF
46 negative regulation of lipid catabolic process GO:0050995 9.76 IL1B TNF
47 positive regulation of macrophage activation GO:0043032 9.76 IL10 TLR4
48 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.76 IL1B TNF
49 positive regulation of interleukin-17 production GO:0032740 9.76 MYD88 NOD2
50 regulation of cytokine secretion GO:0050707 9.76 TLR2 TLR4

Molecular functions related to Q Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.77 ARG1 CCL5 IFNG IL10 IL1B IL4
2 peptidoglycan binding GO:0042834 9.37 NOD2 TLR2
3 interleukin-1 receptor binding GO:0005149 9.32 IL1B MYD88
4 Toll-like receptor binding GO:0035325 9.26 MYD88 TLR2
5 cytokine activity GO:0005125 9.17 CCL5 IFNG IL10 IL1B IL4 IL6
6 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4

Sources for Q Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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