MCID: QTN001
MIFTS: 11

Qt Interval, Variation in

Aliases & Classifications for Qt Interval, Variation in

MalaCards integrated aliases for Qt Interval, Variation in:

Name: Qt Interval, Variation in 57 13

External Ids:

OMIM 57 610141

Summaries for Qt Interval, Variation in

OMIM : 57 The electrocardiographic (ECG) QT interval, a measure of cardiac repolarization, is a genetically influenced quantitative trait with estimated heritability of approximately 30% (Arking et al., 2006). Very long or short QT intervals occur in a heterogeneous collection of mendelian disorders, the various forms of long QT syndrome (LQTS; see 192500) and short QT syndrome (SQTS; see 609620). These are usually due to rare, highly penetrant mutations in ion channel genes that are associated with increased risk of sudden cardiac death (SCD; see 115080). Familial clustering of SCD has been observed, but the vast majority of subjects who are at risk for SCD do not have mutations in the known genes for LQTS or SQTS. (610141)

MalaCards based summary : Qt Interval, Variation in An important gene associated with Qt Interval, Variation in is QTV (QT Interval, Variation In). The drugs Estradiol and Estradiol valerate have been mentioned in the context of this disorder. Affiliated tissues include heart.

Related Diseases for Qt Interval, Variation in

Diseases in the Pr Interval, Variation in family:

Qt Interval, Variation in

Symptoms & Phenotypes for Qt Interval, Variation in

Clinical features from OMIM:

610141

Drugs & Therapeutics for Qt Interval, Variation in

Drugs for Qt Interval, Variation in (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 1 50-28-2 5757
2 Estradiol valerate Approved, Investigational, Vet_approved Phase 1 979-32-8
3
Ethinyl Estradiol Approved Phase 1 57-63-6 5991
4
Moxifloxacin Approved, Investigational Phase 1 354812-41-2, 151096-09-2 152946
5
Norgestimate Approved, Investigational Phase 1 35189-28-7 6540478
6
Polyestradiol phosphate Approved Phase 1 28014-46-2
7 Anti-Bacterial Agents Phase 1,Not Applicable
8 Anti-Infective Agents Phase 1
9 Contraceptive Agents Phase 1
10 Contraceptives, Oral Phase 1
11 Contraceptives, Oral, Combined Phase 1
12 Estradiol 17 beta-cypionate Phase 1
13 Estradiol 3-benzoate Phase 1
14 Hypoglycemic Agents Phase 1
15 Norgestimate, ethinyl estradiol drug combination Phase 1
16 Topoisomerase Inhibitors Phase 1
17 Fluoroquinolones Phase 1
18 Nucleic Acid Synthesis Inhibitors Phase 1
19
Ketamine Approved, Vet_approved Not Applicable 6740-88-1 3821
20
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
21
Dofetilide Approved, Investigational Not Applicable 115256-11-6 71329
22
Sotalol Approved Not Applicable 959-24-0, 3930-20-9 5253
23 Analgesics Not Applicable
24 Anesthetics Not Applicable
25 Anesthetics, Dissociative Not Applicable
26 Anesthetics, General Not Applicable
27 Anesthetics, Intravenous Not Applicable
28 Anesthetics, Local Not Applicable
29 Anti-Arrhythmia Agents Not Applicable
30 Central Nervous System Depressants Not Applicable
31 Diuretics, Potassium Sparing Not Applicable
32 Excitatory Amino Acid Antagonists Not Applicable
33 Excitatory Amino Acids Not Applicable
34 Neurotransmitter Agents Not Applicable
35 Peripheral Nervous System Agents Not Applicable
36 Sodium Channel Blockers Not Applicable
37 Antibiotics, Antitubercular Not Applicable
38 Neurotransmitter Uptake Inhibitors Not Applicable
39 Serotonin Agents Not Applicable
40 Serotonin Uptake Inhibitors Not Applicable
41 Adrenergic Agents Not Applicable
42 Adrenergic Antagonists Not Applicable
43 Adrenergic beta-Antagonists Not Applicable
44 Autonomic Agents Not Applicable
45 Potassium Channel Blockers Not Applicable
46 Sympatholytics Not Applicable
47
Serotonin Investigational, Nutraceutical Not Applicable 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Investigation of Arrhythmogenic Effect of NPC-15 (NPC-15-7) Completed NCT03475459 Phase 1 NPC-15 and/or Placebo
2 Effect of Imeglimin on QT/QTc Intervals in Healthy Subjects Completed NCT02924337 Phase 1 Placebo;Imeglimin;Moxifloxacin
3 Study to Evaluate the Effect Of WCK 2349 on the QT/QTc Interval in Health Volunteers Completed NCT02217930 Phase 1 WCK 2349;Placebo;Moxifloxacin
4 The Effect of Anesthetic Agents Management on ECG Changes of Patients Who Were Operated Under RIVA Completed NCT02063620 Not Applicable Ketamine HCL
5 Effect of Antenatal SSRI Exposure on the QT Interval of Neonates Completed NCT02492347 Not Applicable
6 Using an iPhone ECG to Monitor the QT Interval on Dofetilide and Sotalol Patients Completed NCT02241252 Not Applicable
7 Home Electrocardiogram (ECG) Monitoring After Heart Transplantation Completed NCT01365806

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Genetic Tests for Qt Interval, Variation in

Anatomical Context for Qt Interval, Variation in

MalaCards organs/tissues related to Qt Interval, Variation in:

41
Heart

Publications for Qt Interval, Variation in

Variations for Qt Interval, Variation in

Expression for Qt Interval, Variation in

Search GEO for disease gene expression data for Qt Interval, Variation in.

Pathways for Qt Interval, Variation in

GO Terms for Qt Interval, Variation in

Sources for Qt Interval, Variation in

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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