MCID: QTN001
MIFTS: 10

Qt Interval, Variation in

Aliases & Classifications for Qt Interval, Variation in

MalaCards integrated aliases for Qt Interval, Variation in:

Name: Qt Interval, Variation in 57 13

External Ids:

OMIM 57 610141

Summaries for Qt Interval, Variation in

OMIM : 57 The electrocardiographic (ECG) QT interval, a measure of cardiac repolarization, is a genetically influenced quantitative trait with estimated heritability of approximately 30% (Arking et al., 2006). Very long or short QT intervals occur in a heterogeneous collection of mendelian disorders, the various forms of long QT syndrome (LQTS; see 192500) and short QT syndrome (SQTS; see 609620). These are usually due to rare, highly penetrant mutations in ion channel genes that are associated with increased risk of sudden cardiac death (SCD; see 115080). Familial clustering of SCD has been observed, but the vast majority of subjects who are at risk for SCD do not have mutations in the known genes for LQTS or SQTS. (610141)

MalaCards based summary : Qt Interval, Variation in An important gene associated with Qt Interval, Variation in is QTV (QT Interval, Variation In). The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder.

Related Diseases for Qt Interval, Variation in

Diseases in the Pr Interval, Variation in family:

Qt Interval, Variation in

Symptoms & Phenotypes for Qt Interval, Variation in

Clinical features from OMIM:

610141

Drugs & Therapeutics for Qt Interval, Variation in

Drugs for Qt Interval, Variation in (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 1 50-28-2 5757
2
Polyestradiol phosphate Approved Phase 1 28014-46-2
3
Moxifloxacin Approved, Investigational Phase 1 354812-41-2, 151096-09-2 152946
4
Ethinyl Estradiol Approved Phase 1 57-63-6 5991
5
Norgestimate Approved, Investigational Phase 1 35189-28-7 6540478
6 Estradiol valerate Approved, Investigational, Vet_approved Phase 1 979-32-8
7
Melatonin Approved, Nutraceutical, Vet_approved Phase 1 73-31-4 896
8 Protective Agents Phase 1
9 Antioxidants Phase 1
10 Central Nervous System Depressants Phase 1,Not Applicable
11 Estradiol 17 beta-cypionate Phase 1
12 Topoisomerase Inhibitors Phase 1
13 Hypoglycemic Agents Phase 1
14 Anti-Infective Agents Phase 1
15 Estradiol 3-benzoate Phase 1
16 Anti-Bacterial Agents Phase 1,Not Applicable
17 Contraceptives, Oral Phase 1
18 Contraceptives, Oral, Combined Phase 1
19 Contraceptive Agents Phase 1
20 Norgestimate, ethinyl estradiol drug combination Phase 1
21 Fluoroquinolones Phase 1
22 Nucleic Acid Synthesis Inhibitors Phase 1
23
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
24
Ketamine Approved, Vet_approved Not Applicable 6740-88-1 3821
25
Sotalol Approved Not Applicable 959-24-0, 3930-20-9 5253
26
Dofetilide Approved, Investigational Not Applicable 115256-11-6 71329
27
Citalopram Approved 59729-33-8 2771
28
Dopamine Approved 51-61-6, 62-31-7 681
29
Methylphenidate Approved, Investigational 113-45-1 4158
30 Anesthetics, Local Not Applicable
31 Analgesics Not Applicable
32 Anesthetics, Dissociative Not Applicable
33 Anti-Arrhythmia Agents Not Applicable
34 Excitatory Amino Acids Not Applicable
35 Diuretics, Potassium Sparing Not Applicable
36 Excitatory Amino Acid Antagonists Not Applicable
37 Sodium Channel Blockers Not Applicable
38 Peripheral Nervous System Agents Not Applicable
39 Anesthetics, Intravenous Not Applicable
40 Neurotransmitter Agents Not Applicable
41 Anesthetics Not Applicable
42 Anesthetics, General Not Applicable
43 Serotonin Agents Not Applicable
44 Antibiotics, Antitubercular Not Applicable
45 Serotonin Uptake Inhibitors Not Applicable
46 Neurotransmitter Uptake Inhibitors Not Applicable
47 Potassium Channel Blockers Not Applicable
48 Adrenergic Agents Not Applicable
49 Adrenergic beta-Antagonists Not Applicable
50 Adrenergic Antagonists Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Investigation of Arrhythmogenic Effect of NPC-15 (NPC-15-7) Completed NCT03475459 Phase 1 NPC-15 and/or Placebo
2 Effect of Imeglimin on QT/QTc Intervals in Healthy Subjects Completed NCT02924337 Phase 1 Placebo;Imeglimin;Moxifloxacin
3 Study to Evaluate the Effect Of WCK 2349 on the QT/QTc Interval in Health Volunteers Completed NCT02217930 Phase 1 WCK 2349;Placebo;Moxifloxacin
4 The Effect of Anesthetic Agents Management on ECG Changes of Patients Who Were Operated Under RIVA Completed NCT02063620 Not Applicable Ketamine HCL
5 Effect of Antenatal SSRI Exposure on the QT Interval of Neonates Completed NCT02492347 Not Applicable
6 Using an iPhone ECG to Monitor the QT Interval on Dofetilide and Sotalol Patients Completed NCT02241252 Not Applicable
7 Home Electrocardiogram (ECG) Monitoring After Heart Transplantation Completed NCT01365806
8 Drug-induced Repolarization ECG Changes Active, not recruiting NCT03642405

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Sources for Qt Interval, Variation in

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
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30 HGMD
31 HMDB
32 HPO
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45 MESH via Orphanet
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69 SNOMED-CT via HPO
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74 UMLS via Orphanet
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