MCID: QTN001
MIFTS: 12

Qt Interval, Variation in

Aliases & Classifications for Qt Interval, Variation in

MalaCards integrated aliases for Qt Interval, Variation in:

Name: Qt Interval, Variation in 58 13

External Ids:

OMIM 58 610141

Summaries for Qt Interval, Variation in

OMIM : 58 The electrocardiographic (ECG) QT interval, a measure of cardiac repolarization, is a genetically influenced quantitative trait with estimated heritability of approximately 30% (Arking et al., 2006). Very long or short QT intervals occur in a heterogeneous collection of mendelian disorders, the various forms of long QT syndrome (LQTS; see 192500) and short QT syndrome (SQTS; see 609620). These are usually due to rare, highly penetrant mutations in ion channel genes that are associated with increased risk of sudden cardiac death (SCD; see 115080). Familial clustering of SCD has been observed, but the vast majority of subjects who are at risk for SCD do not have mutations in the known genes for LQTS or SQTS. (610141)

MalaCards based summary : Qt Interval, Variation in An important gene associated with Qt Interval, Variation in is QTV (QT Interval, Variation In). The drugs Estradiol and Ethinyl Estradiol have been mentioned in the context of this disorder. Affiliated tissues include brain and heart.

Related Diseases for Qt Interval, Variation in

Diseases in the Pr Interval, Variation in family:

Qt Interval, Variation in

Symptoms & Phenotypes for Qt Interval, Variation in

Clinical features from OMIM:

610141

Drugs & Therapeutics for Qt Interval, Variation in

Drugs for Qt Interval, Variation in (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 1 50-28-2 5757
2
Ethinyl Estradiol Approved Phase 1 57-63-6 5991
3
Polyestradiol phosphate Approved Phase 1 28014-46-2
4
Moxifloxacin Approved, Investigational Phase 1 354812-41-2, 151096-09-2 152946
5
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
6
Norgestimate Approved, Investigational Phase 1 35189-28-7 6540478
7
Melatonin Approved, Nutraceutical, Vet_approved Phase 1 73-31-4 896
8 Peripheral Nervous System Agents Phase 1,Not Applicable
9 Anti-Bacterial Agents Phase 1,Not Applicable
10 Anti-Inflammatory Agents Phase 1
11 Contraceptive Agents Phase 1
12 Cyclooxygenase Inhibitors Phase 1
13 Anti-Infective Agents Phase 1
14 Contraceptives, Oral Phase 1
15 Anti-Inflammatory Agents, Non-Steroidal Phase 1
16 Cyclooxygenase 2 Inhibitors Phase 1
17 Topoisomerase Inhibitors Phase 1
18 Estradiol 17 beta-cypionate Phase 1
19 Estradiol 3-benzoate Phase 1
20 Norgestimate, ethinyl estradiol drug combination Phase 1
21 Analgesics Phase 1,Not Applicable
22 Contraceptives, Oral, Combined Phase 1
23 Antirheumatic Agents Phase 1
24 Analgesics, Non-Narcotic Phase 1
25 Protective Agents Phase 1
26 Central Nervous System Depressants Phase 1,Not Applicable
27 Antioxidants Phase 1
28 Hypoglycemic Agents Phase 1
29
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
30
Ketamine Approved, Vet_approved Not Applicable 6740-88-1 3821
31
Dofetilide Approved, Investigational Not Applicable 115256-11-6 71329
32
Sotalol Approved Not Applicable 3930-20-9, 959-24-0 5253
33
Citalopram Approved 59729-33-8 2771
34
carbamide peroxide Approved 124-43-6
35
Dopamine Approved 62-31-7, 51-61-6 681
36
Methylphenidate Approved, Investigational 113-45-1 4158
37
Calcium Approved, Nutraceutical 7440-70-2 271
38 Excitatory Amino Acid Antagonists Not Applicable
39 Sodium Channel Blockers Not Applicable
40 Anti-Arrhythmia Agents Not Applicable
41 Neurotransmitter Agents Not Applicable
42 Anesthetics Not Applicable
43 Anesthetics, Dissociative Not Applicable
44 Anesthetics, Intravenous Not Applicable
45 Anesthetics, Local Not Applicable
46 Excitatory Amino Acids Not Applicable
47 Anesthetics, General Not Applicable
48 Diuretics, Potassium Sparing Not Applicable
49 Antibiotics, Antitubercular Not Applicable
50 Serotonin Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Study to Evaluate Effect on QT/QTc Interval After Multiple Dose of Celecoxib Completed NCT03822520 Phase 1 Celecoxib;Moxifloxacin
2 Investigation of Arrhythmogenic Effect of NPC-15 (NPC-15-7) Completed NCT03475459 Phase 1 NPC-15 and/or Placebo
3 Effect of Imeglimin on QT/QTc Intervals in Healthy Subjects Completed NCT02924337 Phase 1 Placebo;Imeglimin;Moxifloxacin
4 Study to Evaluate the Effect Of WCK 2349 on the QT/QTc Interval in Health Volunteers Completed NCT02217930 Phase 1 WCK 2349;Placebo;Moxifloxacin
5 The Effect of Anesthetic Agents Management on ECG Changes of Patients Who Were Operated Under RIVA Completed NCT02063620 Not Applicable Ketamine HCL
6 Effect of Antenatal SSRI Exposure on the QT Interval of Neonates Completed NCT02492347 Not Applicable
7 Using an iPhone ECG to Monitor the QT Interval on Dofetilide and Sotalol Patients Completed NCT02241252 Not Applicable
8 Home Electrocardiogram (ECG) Monitoring After Heart Transplantation Completed NCT01365806
9 Drug-induced Repolarization ECG Changes Active, not recruiting NCT03642405

Search NIH Clinical Center for Qt Interval, Variation in

Genetic Tests for Qt Interval, Variation in

Anatomical Context for Qt Interval, Variation in

MalaCards organs/tissues related to Qt Interval, Variation in:

42
Brain, Heart

Publications for Qt Interval, Variation in

Variations for Qt Interval, Variation in

Expression for Qt Interval, Variation in

Search GEO for disease gene expression data for Qt Interval, Variation in.

Pathways for Qt Interval, Variation in

GO Terms for Qt Interval, Variation in

Sources for Qt Interval, Variation in

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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