Quadricuspid Aortic Valve disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: QDR002 MIFTS: 19	Quadricuspid Aortic Valve Categories: Cardiovascular diseases, Fetal diseases, Rare diseases
Genes Tissues Related diseases Publications Expand all tables

Sources

Aliases & Classifications for Quadricuspid Aortic Valve

MalaCards integrated aliases for Quadricuspid Aortic Valve:

Name: Quadricuspid Aortic Valve ⁵⁸

Classifications:

MalaCards categories:
Global: Fetal diseases Rare diseases
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare circulatory system diseases

Rare cardiac malformations

Developmental anomalies during embryogenesis

External Ids:

Orphanet ⁵⁸ ORPHA542568

Sources

Summaries for Quadricuspid Aortic Valve

MalaCards based summary : Quadricuspid Aortic Valve is related to ehlers-danlos syndrome, classic-like and adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency. An important gene associated with Quadricuspid Aortic Valve is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2). Affiliated tissues include heart and eye.

Wikipedia : ⁷⁴ A quadricuspid aortic valve (QAV) is a rare congenital heart defect characterized by the presence of... more...

Sources

Related Diseases for Quadricuspid Aortic Valve

Diseases related to Quadricuspid Aortic Valve via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)

#	Related Disease	Score	Top Affiliating Genes
1	ehlers-danlos syndrome, classic-like	29.8	TNXB LOC106780803
2	adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency	29.6	TNXB CYP21A2
3	ehlers-danlos syndrome	29.0	TNXB LOC106780804 LOC106780803 CYP21A2
4	aortic valve insufficiency	11.2
5	endocarditis	10.8
6	infective endocarditis	10.7
7	heart septal defect	10.7
8	aneurysm	10.6
9	aortic aneurysm	10.6
10	ventricular septal defect	10.6
11	atrial heart septal defect	10.5
12	atrial standstill 1	10.5
13	aortic valve disease 2	10.5
14	mitral valve insufficiency	10.5
15	aneurysm of sinus of valsalva	10.5
16	aortic dissection	10.4
17	aortic valve disease 1	10.4
18	orthostatic intolerance	10.4
19	patent ductus arteriosus 1	10.4
20	hypertrophic cardiomyopathy	10.4
21	tetralogy of fallot	10.3
22	patent foramen ovale	10.3
23	tricuspid valve insufficiency	10.3
24	stroke, ischemic	10.2
25	angina pectoris	10.2
26	dextro-looped transposition of the great arteries	10.2
27	cardiac tamponade	10.2
28	pericarditis	10.2
29	heart valve disease	10.2
30	subvalvular aortic stenosis	10.2
31	syncope	10.2
32	arteries, anomalies of	10.1
33	cardiac conduction defect	10.1
34	cat eye syndrome	10.1
35	coarctation of aorta	10.1
36	ehlers-danlos syndrome, hypermobility type	10.1
37	pectus excavatum	10.1
38	rheumatoid arthritis	10.1
39	supravalvular aortic stenosis	10.1
40	thrombocytopenic purpura, autoimmune	10.1
41	down syndrome	10.1
42	williams-beuren syndrome	10.1
43	lipoid congenital adrenal hyperplasia	10.1
44	ventricular fibrillation, paroxysmal familial, 1	10.1
45	transposition of the great arteries, dextro-looped 1	10.1
46	microvascular complications of diabetes 3	10.1
47	microvascular complications of diabetes 4	10.1
48	microvascular complications of diabetes 6	10.1
49	microvascular complications of diabetes 7	10.1
50	spastic paraplegia, intellectual disability, nystagmus, and obesity	10.1

Graphical network of the top 20 diseases related to Quadricuspid Aortic Valve:

Sources

Symptoms & Phenotypes for Quadricuspid Aortic Valve

Sources

Drugs & Therapeutics for Quadricuspid Aortic Valve

Search Clinical Trials , NIH Clinical Center for Quadricuspid Aortic Valve

Sources

Genetic Tests for Quadricuspid Aortic Valve

Sources

Anatomical Context for Quadricuspid Aortic Valve

MalaCards organs/tissues related to Quadricuspid Aortic Valve:

⁴⁰

Heart, Eye

Sources

Publications for Quadricuspid Aortic Valve

Articles related to Quadricuspid Aortic Valve:

(show top 50) (show all 409)

#	Title	Authors	PMID	Year
1	Quadricuspid Aortic Valve. ⁶¹	Mazumdar P...Das M	33527817	2021
2	Prevalence, multimodality imaging characterization, and mid-term prognosis of quadricuspid aortic valves: an analysis of eight cases, based on 160 004 exams performed during 12 years in a tertiary care hospital. ⁶¹	Manuel AM...Fontes-Carvalho R	33400773	2021
3	Quadricuspid aortic valve: a case report and review of literature. ⁶¹	Piracha UG...Patel N	33463363	2021
4	Quadricuspid aortic valve with a hidden left ostium: Case report and literature review. ⁶¹	Soares FR...Antunes MJ	33309128	2021
5	Infective endocarditis of a native quadricuspid aortic valve. ⁶¹	Ascaso M...Quintana E	33444069	2021
6	A Congenital Quadricuspid Aortic Valve Associated With Aortic and Mitral Regurgitation: Case Report and Literature Review. ⁶¹	Shadman S...Sarfarazi M	33542882	2021
7	Normally functioning quadricuspid aortic valve mistaken for bicuspid valve in a septuagenarian. ⁶¹	Molinary MC...Kerut EK	33314256	2020
8	Quadricuspid aortic valve repair by neo-cuspidization of an accessory cusp using autologous pericardium. ⁶¹	Miura Y...Yamazaki F	32285304	2020
9	Quadricuspid aortic valve: 3D-visualization by computed tomography. ⁶¹	Feuchtner GM	31296409	2020
10	Unequal quadricuspid aortic valve stenosis treated with transcatheter aortic valve replacement. ⁶¹	Fukui T...Hasegawa S	33204976	2020
11	Staphylococcal endocarditis in a quadricuspid aortic valve following uncomplicated dengue infection: a case report. ⁶¹	Weerasooriya N...Jayanaga A	32762676	2020
12	Quadricuspid Aortic Valve: A Rare Cause of Aortic Regurgitation. ⁶¹	Douglas A...Safi L	32875189	2020
13	Valve-sparing root replacement without cusp repair for regurgitant quadricuspid aortic valve. ⁶¹	Katahira S...Lichtenberg A	32758559	2020
14	Surgical repair of a quadricuspid aortic valve associated with a ruptured sinus of Valsalva aneurysm. ⁶¹	Xu M...Xiao H	31409494	2020
15	A four-leaf clover: A case report of quadricuspid aortic valve stenosis. ⁶¹	Benkemoun H...Beaufigeau M	32163624	2020
16	Left ventricular hemangioma and quadricuspid aortic valve: a rare combination. ⁶¹	Sun Z...Xie M	31898009	2020
17	Quadricuspid Aortic Valve: A Case Report and Review. ⁶¹	Kariyanna PT...McFarlane IM	32775626	2020
18	The Quandary of the Quadricuspid Aortic Valve-The "Unlucky" 4-Leaf Clover: Case Report and Brief Clinical Review. ⁶¹	Seecheran RV...Seecheran NA	32389028	2020
19	Quadricuspid Aortic Valve: Three Cases Report and Literature Review. ⁶¹	Veronese ET...Jatene FB	31719017	2019
20	Quadricuspid Aortic Valve: A Rare and Incidental Finding. ⁶¹	Kaur M...Reddy S	31819837	2019
21	A quadricuspid aortic valve. ⁶¹	Karolak W...Pawlaczyk R	31220865	2019
22	Erratum: Quadricuspid aortic valve associated with aortic insufficiency contributors. ⁶¹		31621691	2019
23	Tumor-like appearance in ruptured sinus of Valsalva with quadricuspid aortic valve. ⁶¹	Nakano Y...Amano T	31969937	2019
24	Long-term performance of bicuspid and quadricuspid aortic valves: Similarities and differences. ⁶¹	Sharif D...Sharif-Rasslan A	31490580	2019
25	Quadricuspid Aortic Valve With Ostium Secundum Atrial Septal Defect. ⁶¹	Garg A...Sharma GL	31468014	2019
26	Aortic valve repair with valve-sparing root replacement for asymmetric quadricuspid aortic valve and conversion into symmetric tricuspid valve. ⁶¹	Ikeno Y...Okita Y	30910269	2019
27	Transcatheter aortic valve implantation using Evolut R in quadricuspid aortic valve with severe stenosis and regurgitation. ⁶¹	Aoyama R...Tobaru T	30145723	2019
28	[A quadricuspid aortic valve passed unnoticed]. ⁶¹	Bouziane M...Lancellotti P	31373449	2019
29	Phenotypes of aortic valve disease according to detailed anatomical classification of patients who underwent aortic valve replacement surgery. ⁶¹	Sun C...Zheng Z	30954907	2019
30	From Bicuspid to Quadricuspid Aortic Valve: The Clinical Case of a 38-year-old Woman with Chest Pain. ⁶¹	L'Angiocola PD...Lardieri G	31728302	2019
31	Isolated Quadricuspid Aortic Valve as a Cause of Insufficiency-Predominant Aortic Valve Disease. ⁶¹	Desai CK...Stys T	31461233	2019
32	Quadricuspid Aortic Valvulopathy and Acute Type A Aortic Dissection. ⁶¹	Klassen SL...Hutchison SJ	31618780	2019
33	Quadricuspid aortic valve repair. ⁶¹	Mastrobuoni S...El Khoury G	31240194	2019
34	Valve-sparing aortic root replacement combined with bicuspidization for a quadricuspid aortic valve. ⁶¹	Hasegawa S...Okita Y	30256931	2019
35	Severe aortic regurgitation in a quadricuspid aortic valve: A false rheumatic disease. ⁶¹	Belleyo-Belkasem C...Lacalzada-Almeida J	30997100	2019
36	Long-term outcomes in 3 cases of quadricuspid aortic valve, using a new classification system: A case series and literature review. ⁶¹	Tsugu T...Fukuda K	30803004	2019
37	Quadricuspid aortic valve: Case series and review of literature. ⁶¹	Suraci N...Santana O	30592788	2019
38	Quadricuspid aortic valve. ⁶¹	Saran J...Wasowicz M	31995954	2019
39	Quadricuspid aortic valve associated with aortic insufficiency contributors. ⁶¹	Suraci NP...Rosen G	30648691	2019
40	Quadricuspid Aortic Valve: Report of Two Cases and Brief Review. ⁶¹	Oladiran O...Ezioma G	31093380	2019
41	Quadricuspid aortic valve associated with two left main coronary ostia. ⁶¹	Braga A...Neves JP	30306627	2018
42	Intraoperative diagnosis of a quadricuspid aortic valve. ⁶¹	Tatari H...Mortezaeian H	28132534	2018
43	Successful transcatheter aortic valve implantation in a quadricuspid aortic valve with severe stenosis and moderate regurgitation. ⁶¹	Tohoku S...Ando K	29022253	2018
44	Quadricuspid Aortic Valve: Cinematic Rendering. ⁶¹	Chu LC...Fishman EK	29989519	2018
45	Clinical characteristics and surgical outcomes of dysfunctional quadricuspid aortic valve. ⁶¹	Lin Y...Wang C	29936994	2018
46	A quadricuspid aortic valve in an asymptomatic 40-year-old man: a case report. ⁶¹	Pasanisi G...Sassone B	30111367	2018
47	Severe Aortic Regurgitation Caused by Congenital Quadricuspid Aortic Valve With an Anomalous Cord. ⁶¹	Mochizuki Y...Shite J	29887219	2018
48	Quadricuspid Aortic Valve With Sinus of Valsalva Aneurysm. ⁶¹	Leatherby RJ...Fergey S	29518387	2018
49	New morphological classification of congenital quadricuspid aortic valve and its histopathologic features. ⁶¹	Cheng CL...Lin SY	29729634	2018
50	Quadricuspid Aortic Valve Or a Rare Complication of Cocaine Abuse? ⁶¹	Henley MD...Kumar PA	29122430	2018

Sources

Genes for Quadricuspid Aortic Valve

Genes related to Quadricuspid Aortic Valve (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CYP21A2	Cytochrome P450 Family 21 Subfamily A Member 2	Protein Coding	7.18	GeneCards inferred via : Publications (show sections)
2	LOC106780803	Tenascin XB Recombination Region	Biological Region	7.18	GeneCards inferred via : Publications (show sections)
3	LOC106780804	Tenascin XA (Pseudogene) Recombination Region	Biological Region	7.18	GeneCards inferred via : Publications (show sections)
4	TNXB	Tenascin XB	Protein Coding	7.18	GeneCards inferred via : Publications (show sections)

Sources

Variations for Quadricuspid Aortic Valve

Sources

Expression for Quadricuspid Aortic Valve

Search GEO for disease gene expression data for Quadricuspid Aortic Valve.

Sources

Pathways for Quadricuspid Aortic Valve

Sources

GO Terms for Quadricuspid Aortic Valve

Sources

Sources for Quadricuspid Aortic Valve

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia