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MCID: QDR001
MIFTS: 53

Quadriplegia

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Quadriplegia

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MalaCards integrated aliases for Quadriplegia:

Name: Quadriplegia 12 77 15 17 74
Tetraplegia 12 30 15
Tetraplegias 56

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:12835
ICD9CM 36 344.00
MeSH 45 D011782
NCIt 51 C50721
SNOMED-CT 69 11538006
ICD10 34 G82.5 G82.50
UMLS 74 C0034372
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Summaries for Quadriplegia

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MalaCards based summary : Quadriplegia, also known as tetraplegia, is related to pelizaeus-merzbacher disease and spastic quadriplegia, and has symptoms including muscle weakness, ophthalmoplegia and hemiplegia. An important gene associated with Quadriplegia is ELOVL4 (ELOVL Fatty Acid Elongase 4), and among its related pathways/superpathways are Endocrine and other factor-regulated calcium reabsorption and Carbohydrate digestion and absorption. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia : 77 Tetraplegia, also known as quadriplegia, is paralysis caused by illness or injury that results in the... more...

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Related Diseases for Quadriplegia

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Diseases related to Quadriplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
# Related Disease Score Top Affiliating Genes
1 pelizaeus-merzbacher disease 31.9 PLP1 SLC16A2
2 spastic quadriplegia 31.7 ELOVL4 PLP1 SDHA SDHAF1 SDHD SLC16A2
3 spastic cerebral palsy 31.2 ALDH3A2 PLP1 WDR45B
4 mitochondrial complex ii deficiency 31.1 SDHA SDHAF1 SDHD
5 hemiplegia 29.9 ATP1A2 ATP1A3
6 ichthyosis, spastic quadriplegia, and mental retardation 12.4
7 neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures 12.3
8 microcephaly with spastic quadriplegia 12.1
9 spastic quadriplegia, retinitis pigmentosa, and mental retardation 12.1
10 congenital ichthyosis, microcephalus, quadriplegia 12.0
11 absent eyebrows and eyelashes with mental retardation 11.6
12 paraplegia 11.4
13 spinal cord injury 11.3
14 leukodystrophy, hypomyelinating, 6 11.3
15 locked-in syndrome 11.2
16 alternating hemiplegia of childhood 1 11.1
17 alternating hemiplegia of childhood 2 11.1
18 epileptic encephalopathy, early infantile, 53 11.1
19 8p inverted duplication/deletion syndrome 11.1
20 oculocerebral syndrome with hypopigmentation 11.0
21 sjogren-larsson syndrome 11.0
22 hsd10 mitochondrial disease 11.0
23 cortical dysplasia, complex, with other brain malformations 4 11.0
24 microcephaly, seizures, spasticity, and brain calcifications 11.0
25 spastic tetraplegia, thin corpus callosum, and progressive microcephaly 11.0
26 spastic tetraplegia-retinitis pigmentosa-intellectual disability syndrome 11.0
27 spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome 11.0
28 congenital ichthyosis-microcephalus-tetraplegia syndrome 11.0
29 inherited congenital spastic tetraplegia 11.0
30 porphyria variegata 11.0
31 argininemia 11.0
32 allan-herndon-dudley syndrome 11.0
33 epileptic encephalopathy, early infantile, 4 11.0
34 cerebral palsy, spastic quadriplegic, 2 11.0
35 epileptic encephalopathy, early infantile, 5 11.0
36 encephalopathy, progressive, early-onset, with brain atrophy and thin corpus callosum 11.0
37 immunodeficiency 49 11.0
38 familial glucocorticoid deficiency 11.0
39 spastic paraplegia 16 11.0
40 familial hemiplegic migraine 10.2 ATP1A2 ATP1A3
41 hemiplegic migraine 10.2 ATP1A2 ATP1A3
42 epidural abscess 10.1
43 neural crest tumor 10.1 SDHA SDHD
44 kallmann syndrome with spastic paraplegia 10.1
45 mental retardation with spastic paraplegia and palmoplantar hyperkeratosis 10.1
46 pelizaeus-merzbacher-like disease 10.1 PLP1 SLC16A2
47 persistent generalized lymphadenopathy 10.1 SDHA SDHD
48 arthritis 10.1
49 cerebral palsy 10.1
50 spinal stenosis 10.1

Graphical network of the top 20 diseases related to Quadriplegia:



Diseases related to Quadriplegia
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Symptoms & Phenotypes for Quadriplegia

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UMLS symptoms related to Quadriplegia:


muscle weakness, ophthalmoplegia, hemiplegia, quadriparesis, other quadriplegia

MGI Mouse Phenotypes related to Quadriplegia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 ALDH3A2 ATP1A2 ATP1A3 ELOVL4 PIK3C2A PLP1
2 nervous system MP:0003631 9.23 ALDH3A2 ATP1A2 ATP1A3 ELOVL4 PLP1 SDHD
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Drugs & Therapeutics for Quadriplegia

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Drugs for Quadriplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 4,Not Applicable 1401-55-4
2
Benzocaine Approved, Investigational Phase 4,Not Applicable 94-09-7, 1994-09-7 2337
3
Midodrine Approved Phase 4,Phase 2 133163-28-7, 42794-76-3 4195
4
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
5
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
6
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
7
Cefoxitin Approved Phase 4 35607-66-0 441199
8
Acetaminophen Approved Phase 4 103-90-2 1983
9
Baclofen Approved Phase 4 1134-47-0 2284
10
Melatonin Approved, Nutraceutical, Vet_approved Phase 4,Phase 1 73-31-4 896
11 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
12 Adrenergic Agents Phase 4,Phase 2,Phase 1,Not Applicable
13 Adrenergic Agonists Phase 4,Phase 2,Phase 1,Not Applicable
14 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
15 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
16 Cholinergic Agents Phase 4,Phase 2,Phase 1,Not Applicable
17 Vasoconstrictor Agents Phase 4,Phase 2
18 Sympathomimetics Phase 4,Phase 2
19 Adrenergic alpha-Agonists Phase 4,Phase 2
20 Omega 3 Fatty Acid Phase 4
21 Antioxidants Phase 4,Phase 2,Phase 3,Phase 1
22 Central Nervous System Depressants Phase 4,Phase 1,Phase 2
23 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
24 Botulinum Toxins, Type A Phase 4
25 abobotulinumtoxinA Phase 4
26 Acetylcholine Release Inhibitors Phase 4
27 Botulinum Toxins Phase 4
28 Neuromuscular Agents Phase 4
29 Phosphodiesterase 5 Inhibitors Phase 4
30 Phosphodiesterase Inhibitors Phase 4
31 Vasodilator Agents Phase 4,Phase 2,Phase 3
32 Analgesics Phase 4,Phase 1,Phase 2
33 Anti-Infective Agents Phase 4
34 beta-Lactams Phase 4
35 Analgesics, Non-Narcotic Phase 4,Phase 1,Phase 2
36 Lactams Phase 4
37 Antipyretics Phase 4
38 Anti-Bacterial Agents Phase 4
39 Anesthetics Phase 4,Phase 1,Not Applicable
40 Anesthetics, General Phase 4
41
Nitric Oxide Approved Phase 2, Phase 3,Phase 3,Phase 1 10102-43-9 145068
42
Fenofibrate Approved Phase 2, Phase 3 49562-28-9 3339
43
Nitroarginine Experimental, Investigational Phase 2, Phase 3,Phase 3 2149-70-4
44 Respiratory System Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
45 Bronchodilator Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
46 Anti-Asthmatic Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
47 arginine Phase 2, Phase 3,Phase 3
48 NG-Nitroarginine Methyl Ester Phase 2, Phase 3,Phase 3
49 Endothelium-Dependent Relaxing Factors Phase 2, Phase 3,Phase 3
50 Free Radical Scavengers Phase 2, Phase 3,Phase 3

Interventional clinical trials:

(show top 50) (show all 153)
# Name Status NCT ID Phase Drugs
1 Eyegaze Systems for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943656 Phase 4
2 Body Temperature in Persons With Tetraplegia When Exposed to Cold Completed NCT01822535 Phase 4 Midodrine hydrochloride
3 Omega-3 Supplementation for Tetraplegics With Poor Cholesterol Levels Completed NCT01896037 Phase 4
4 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia Completed NCT00507546 Phase 4 Ramelteon;Placebo
5 Diaphragmatic Reinnervation of Tetraplegic Patients With Respiratory Insufficiency Completed NCT01350297 Phase 4
6 Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury. Completed NCT00320281 Phase 4 botulinum toxin A
7 Effect of Tadalafil (Cialis) on the Cardiovascular System of Spinal Cord Injury (SCI) Males Completed NCT01067391 Phase 4 tadalafil;placebo
8 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
9 Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia Recruiting NCT02379156 Phase 4 Midodrine Hydrochloride
10 Nerve Transfer Reconstruction in the Tetraplegic Upper Extremity Recruiting NCT01579604 Phase 4
11 Does Oral Baclofen Improve Care and Comfort in Spastic Children in Nursing Homes? Terminated NCT00752934 Phase 4 oral baclofen + placebo;placebo + oral baclofen
12 SCIPA (Spinal Cord Injury and Physical Activity) Hands-On: Early Intensive Hand Rehabilitation After Spinal Cord Injury Unknown status NCT01086930 Phase 3
13 Restoration of Upper Limb Function in Individuals With Sub-Acute Spinal Cord Injury Unknown status NCT01292811 Phase 3
14 Retraining Walking After Spinal Cord Injury Unknown status NCT00059553 Phase 2, Phase 3
15 Exhaled Levels of Nitric Oxide Completed NCT00753948 Phase 2, Phase 3 N-Nitro L-arginine-methylester (L-NAME)
16 Prevention of Low Blood Pressure in Persons With Tetraplegia Completed NCT00237770 Phase 2, Phase 3 N-Nitro L-arginine-methylester (L-NAME)
17 MEOPA to Improve Physical Therapy Results After Multilevel Surgery Completed NCT00632528 Phase 3 MEOPA;Medicinal air
18 In-home Telerehabilitation for Quadriplegic Hand Function Completed NCT00656149 Phase 2, Phase 3
19 Fenofibrate Treatment in SCI Completed NCT02455336 Phase 2, Phase 3 Fenofibrate
20 Combined Robotic Training and tDCS in Chronic SCI Recruiting NCT03555838 Phase 3
21 High Doses of 4-aminopyridine in Clinically Complete Chronic Spinal Cord Injury Patients. Not yet recruiting NCT03899584 Phase 3 4-Aminopyridine;Placebo oral capsule
22 Study of the Impact of the Use of a Corset on the Respiratory Function of Patients With Spinal Cord Injury Withdrawn NCT01569360 Phase 3
23 Cethrin in Acute Cervical Spinal Cord Injury Withdrawn NCT02053883 Phase 2, Phase 3 Cethrin (BA-210);Placebo
24 Spinal Cord Neuromodulation for SCI Unknown status NCT02313194 Phase 1, Phase 2
25 Rehabilitation of the Upper Extremity With Enhanced Proprioceptive Feedback Following Incomplete Spinal Cord Injury Unknown status NCT00833105 Phase 1, Phase 2
26 Surgical Management of Spinal Cord Injuries In Neck Unknown status NCT00475748 Phase 2
27 Safety and Efficacy of L-NAME and Midodrine to Increase MAP Completed NCT00835224 Phase 2 L-NAME;Midodrine;Placebo
28 Spinal Cord Injury Leg Rehabilitation Completed NCT01498991 Phase 1, Phase 2
29 FES Therapy:Restoring Voluntary Grasping Function in Chronic SCI Completed NCT01208688 Phase 2
30 Dose Escalation Study of AST-OPC1 in Spinal Cord Injury Completed NCT02302157 Phase 1, Phase 2
31 A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries Completed NCT00500812 Phase 1, Phase 2 Cethrin
32 The Effects of Passive Gait Training in Complete Motor Spinal Cord Injury (SCI) Completed NCT01349478 Phase 1, Phase 2
33 Study to Assess Safety, Tolerability and MTD of a Central Pattern Generator-activating Tritherapy (SPINALON) in Patients With Chronic Spinal Cord Injury Completed NCT01484184 Phase 1, Phase 2 SPINALON (buspirone + levodopa + cardidopa)
34 [BrainConnexion] - Neurodevice Phase II Trial Recruiting NCT03811301 Phase 2
35 Olaparib With or Without Atezolizumab in Treating Patients With Locally Advanced or Metastatic Non-HER2-Positive Breast Cancer Recruiting NCT02849496 Phase 2 Atezolizumab;Olaparib
36 24hr Effects of Tiotropium Bromide in Tetraplegia Enrolling by invitation NCT02586649 Phase 2 Tiotropium Bromide;Placebo
37 Autologous Incubated Macrophages for Patients With Complete Spinal Cord Injuries Suspended NCT00073853 Phase 2
38 Cannabis for Spasticity in Multiple Sclerosis Terminated NCT00682929 Phase 1, Phase 2 Inhaled Cannabis;Oral THC;Oral Placebo;Inhaled placebo
39 Effect of Air-stacking on Peak Cough Flow in Patients With Acute Cervical or High Thoracic Spinal Cord Injury Withdrawn NCT01046175 Phase 2
40 Effects of Anticholinergic or Long-Acting Beta 2 Agonist on FeNO and Pulmonary Function in SCI Unknown status NCT01355991 Phase 1 Tiotropium;Salmeterol
41 Acute and Chronic Effects of Inhaled Steroids on Pulmonary Function in Persons With Spinal Cord Injury Unknown status NCT01353599 Phase 1 Mometasone furoate
42 The Role of Melatonin in the Regulation of Blood Coagulation Completed NCT01741389 Phase 1 Melatonin ("Circadin")
43 Evaluation of a Tongue Operated Assistive Technology for Individuals With Severe Paralysis Completed NCT01124292 Phase 1
44 Use of Interactive Gaming for Enhanced Function After Spinal Cord Injury Completed NCT01537978 Phase 1
45 Improving Ambulatory Community Access After Paralysis Recruiting NCT01570816 Phase 1
46 The Safety of ahSC in Chronic SCI With Rehabilitation Active, not recruiting NCT02354625 Phase 1
47 Abdominal Functional Electrical Stimulation in Tetraplegia Unknown status NCT00202631 Not Applicable
48 Electrical Activation of The Diaphragm for Ventilatory Assist Unknown status NCT00010374 Not Applicable
49 Abdominal Functional Electrical Stimulation Training and Its Effect on Mechanical Insufflation-Exsufflation Unknown status NCT01800409 Not Applicable
50 UPNRIDE Powered Wheelchair for Individuals With Walking Impairment: Evaluation of Safety and Usability Unknown status NCT02983955 Not Applicable

Search NIH Clinical Center for Quadriplegia

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Genetic Tests for Quadriplegia

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Genetic tests related to Quadriplegia:

# Genetic test Affiliating Genes
1 Tetraplegia 30
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Anatomical Context for Quadriplegia

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MalaCards organs/tissues related to Quadriplegia:

42
Spinal Cord, Brain, Bone, Testes, Heart, Tongue, Breast
Sources

Publications for Quadriplegia

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Articles related to Quadriplegia:

(show top 50) (show all 1342)
# Title Authors Year
1
Tetraplegia associated with post-operative syringomyelia in spinal tuberculosis: a result of an epidural compartment syndrome? ( 30774988 )
2019
2
Does auto-PAP work in patients with acute quadriplegia and sleep-disordered breathing? ( 30610154 )
2019
3
Acute-onset quadriplegia with hyperreflexia. ( 30624189 )
2019
4
Congenital deformation of the posterior arch of the atlas: Subluxation of the atlanto-axial joint with temporary quadriplegia. ( 30719304 )
2019
5
Alternative scapular stabilization exercises to target strength, endurance and function of shoulders in tetraplegia: A prospective non-controlled intervention study. ( 29141513 )
2019
6
Construction and evaluation of a model for wheelchair propulsion in an individual with tetraplegia. ( 30255235 )
2019
7
Changes in Motor Evoked Potential Latency during Grasping after Tetraplegia. ( 30673355 )
2019
8
Rare Cause of Acute Tetraplegia and Respiratory Arrest: Cervicomedullary Neuroenteric Cyst in a Child: Case Report. ( 30701147 )
2019
9
Needs of individuals with tetraplegia and expectations regarding implanted neuroprosthesis. ( 30710636 )
2019
10
Correction: Clinical efficacy of upper limb robotic therapy in people with tetraplegia: a pilot randomized controlled trial. ( 30718747 )
2019
11
Reach out and grasp the opportunity: reconstructive hand surgery in tetraplegia. ( 30744461 )
2019
12
Reorganization of muscle synergies in 2 individuals with C5 and C6 tetraplegia after biceps-triceps and posterior deltoid-triceps tendon transfers. ( 30798792 )
2019
13
Thoracoscopic intercostal to phrenic nerve transfer for diaphragmatic reanimation in a child with tetraplegia. ( 30883296 )
2019
14
Clinically significant gains in skillful grasp coordination by an individual with tetraplegia using an implanted brain-computer interface with forearm transcutaneous muscle stimulation. ( 30902630 )
2019
15
Life-Threatening Hypokalemic Quadriplegia in a Postoperative Patient. ( 29482687 )
2018
16
Descriptive pilot study of vividness and temporal equivalence during motor imagery training after quadriplegia. ( 29944923 )
2018
17
Acute Onset of Quadriplegia Secondary to Hypoparathyroidism: Mimicker of AMAN Variant of GBS. ( 29482695 )
2018
18
Nonsurgical management of an extensive spontaneous spinal epidural hematoma causing quadriplegia and respiratory distress in a choledocholithiasis patient: A case report: Erratum. ( 29369212 )
2018
19
Effects of Walkbot gait training on kinematics, kinetics, and clinical gait function in paraplegia and quadriplegia. ( 29660947 )
2018
20
Development of acute promyelocytic leukemia in a patient with tetraplegia while in inpatient rehabilitation: A case report. ( 28929913 )
2018
21
Energy expenditure after spinal cord injury in people with motor-complete tetraplegia or motor-complete paraplegia. ( 29238094 )
2018
22
Differences in Cortical Gray Matter Atrophy of Paraplegia and Tetraplegia after Complete Spinal Cord Injury. ( 30430910 )
2018
23
Clinical management of quadriplegia in low and middle-income countries: a patient's road to physiotherapy, prostheses and rehabilitation. ( 30054323 )
2018
24
The First Case Report of West Nile Virus-Induced Acute Flaccid Quadriplegia in Canada. ( 30123588 )
2018
25
Transient Anarthria and Quadriplegia in a Patient with Basilar Artery Hypoplasia and Coincidental Intracranial Lipoma: A Case Report. ( 30519181 )
2018
26
Positive airway pressure for sleep-disordered breathing in acute quadriplegia: a randomised controlled trial. ( 30538163 )
2018
27
Hyper Acute Quadriplegia with Chronic Lead Toxicity; a Case Report. ( 30584560 )
2018
28
Chlorpyrifos-Induced Delayed Neurotoxicity with A Rare Presentation of Flaccid Quadriplegia: A Diagnostic Challenge. ( 30755975 )
2018
29
Energy Expenditure as a Function of Activity Level After Spinal Cord Injury: The Need for Tetraplegia-Specific Energy Balance Guidelines. ( 30283348 )
2018
30
Double nerve transfer for restoration of hand grasp and release in C7 tetraplegia following complete cervical spinal cord injury. ( 30218162 )
2018
31
The impact of a specialized spinal cord injury center as compared with non-specialized centers on the acute respiratory management of patients with complete tetraplegia: an observational study. ( 29138486 )
2018
32
Periodic limb movements in tetraplegia. ( 28464758 )
2018
33
Leveraging the Medical Context to Increase Upper Extremity Reconstruction Among Patients With Tetraplegia: A Qualitative Analysis. ( 28782539 )
2018
34
Transcranial direct current stimulation (tDCS) paired with massed practice training to promote adaptive plasticity and motor recovery in chronic incomplete tetraplegia: A pilot study. ( 28784042 )
2018
35
Fatal innominate artery hemorrhage in a patient with tetraplegia: Case report and literature review. ( 29323630 )
2018
36
Electrical stimulation-a mapping system for hand dysfunction in tetraplegia. ( 29358674 )
2018
37
Rapid calibration of an intracortical brain-computer interface for people with tetraplegia. ( 29363625 )
2018
38
Acute tetraplegia following laryngotracheal reconstruction surgery. ( 29416908 )
2018
39
Adaptive motor cortex plasticity following grip reconstruction in individuals with tetraplegia. ( 29439365 )
2018
40
Evaluation of the graded redefined assessment of strength, sensibility and prehension (GRASSP) in children with tetraplegia. ( 29626193 )
2018
41
Persistent urine leakage around a suprapubic catheter: the experience of a person with chronic tetraplegia. ( 29644100 )
2018
42
Genioglossus reflex responses to negative upper airway pressure are altered in people with tetraplegia and obstructive sleep apnoea. ( 29658103 )
2018
43
A term vaginal delivery by a patient with traumatic tetraplegia: A case report. ( 29668610 )
2018
44
Dexterous Control of Seven Functional Hand Movements Using Cortically-Controlled Transcutaneous Muscle Stimulation in a Person With Tetraplegia. ( 29670506 )
2018
45
Diagnostic accuracy of a two-stage model for detecting obstructive sleep apnoea in chronic tetraplegia. ( 29735608 )
2018
46
Need and availability of assistive devices to compensate for impaired hand function of individuals with tetraplegia. ( 29863967 )
2018
47
Transcutaneous Electrical Spinal Stimulation Promotes Long-Term Recovery of Upper Extremity Function in Chronic Tetraplegia. ( 29877852 )
2018
48
Outcomes of reconstructive hand surgery in patients with tetraplegia and neuropathic pain. ( 29904187 )
2018
49
Effect of coil orientation on motor-evoked potentials in humans with tetraplegia. ( 29923194 )
2018
50
Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation. ( 29985456 )
2018
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Variations for Quadriplegia

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Expression for Quadriplegia

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Search GEO for disease gene expression data for Quadriplegia.
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Pathways for Quadriplegia

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Pathways related to Quadriplegia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Endocrine and other factor-regulated calcium reabsorption 38
11 ATP1A2 ATP1A3
2
Carbohydrate digestion and absorption 38
10.9 ATP1A2 ATP1A3
3
Thyroid hormone signaling pathway 38
10.86 ATP1A2 ATP1A3 SLC16A2
4
Aldosterone-regulated sodium reabsorption 38
10.72 ATP1A2 ATP1A3
5
Proximal tubule bicarbonate reclamation 38
10.32 ATP1A2 ATP1A3
Sources

GO Terms for Quadriplegia

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Cellular components related to Quadriplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 9.5 ATP1A2 PLP1 SDHA
2 sodium:potassium-exchanging ATPase complex GO:0005890 9.16 ATP1A2 ATP1A3
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.96 SDHA SDHD
4 extracellular vesicle GO:1903561 8.8 ATP1A2 ATP1A3 SPTAN1
5 membrane GO:0016020 10.03 ALDH3A2 ATP1A2 ATP1A3 ELOVL4 KANK1 PIK3C2A

Biological processes related to Quadriplegia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.49 ATP1A2 ATP1A3
2 tricarboxylic acid cycle GO:0006099 9.48 SDHA SDHD
3 ATP hydrolysis coupled proton transport GO:0015991 9.46 ATP1A2 ATP1A3
4 cellular sodium ion homeostasis GO:0006883 9.43 ATP1A2 ATP1A3
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.4 ATP1A2 ATP1A3
6 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.37 ATP1A2 ATP1A3
7 cellular potassium ion homeostasis GO:0030007 9.32 ATP1A2 ATP1A3
8 cellular response to steroid hormone stimulus GO:0071383 9.26 ATP1A2 ATP1A3
9 sodium ion export across plasma membrane GO:0036376 9.16 ATP1A2 ATP1A3
10 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.96 SDHA SDHD
11 response to glycoside GO:1903416 8.62 ATP1A2 ATP1A3

Molecular functions related to Quadriplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 9.5 ATP1A2 ATP1A3 TBCD
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP1A2 ATP1A3
3 steroid hormone binding GO:1990239 9.16 ATP1A2 ATP1A3
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.96 SDHA SDHD
5 succinate dehydrogenase activity GO:0000104 8.62 SDHA SDHD
Sources

Sources for Quadriplegia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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