MCID: QDR001
MIFTS: 46

Quadriplegia

Categories: Neuronal diseases
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Aliases & Classifications for Quadriplegia

MalaCards integrated aliases for Quadriplegia:

Name: Quadriplegia 11 75 43 14 16 71 75
Tetraplegia 11 28 14 75
Tetraplegias 53

Classifications:



External Ids:

Disease Ontology 11 DOID:12835
ICD9CM 34 344.00
MeSH 43 D011782
NCIt 49 C50721
SNOMED-CT 68 11538006
ICD10 31 G82.5
UMLS 71 C0034372

Summaries for Quadriplegia

MalaCards based summary: Quadriplegia, also known as tetraplegia, is related to leukodystrophy, hypomyelinating, 6 and pelizaeus-merzbacher disease, and has symptoms including muscle weakness, ophthalmoplegia and hemiplegia. An important gene associated with Quadriplegia is ELOVL4 (ELOVL Fatty Acid Elongase 4), and among its related pathways/superpathways is Oligodendrocyte specification and differentiation, leading to myelin components for CNS. The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and tongue, and related phenotypes are nervous system and homeostasis/metabolism

Wikipedia: 75 Tetraplegia, also known as quadriplegia, is defined as the dysfunction or loss of motor and/or sensory... more...

Related Diseases for Quadriplegia

Diseases related to Quadriplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 594)
# Related Disease Score Top Affiliating Genes
1 leukodystrophy, hypomyelinating, 6 32.0 TBCC PLP1 ATP1A3
2 pelizaeus-merzbacher disease 31.8 SLC16A2 PLP1 MOG
3 alternating hemiplegia of childhood 31.6 SLC16A2 ATP1A3 ATP1A2
4 spastic quadriplegia 31.6 WDR45B SPTAN1 SLC16A2 SEC31A SDHD PLP1
5 allan-herndon-dudley syndrome 31.2 SLC16A2 PLP1
6 spastic cerebral palsy 30.9 WDR45B SPTAN1 SLC16A2 PLP1 KANK1 ELOVL4
7 cerebral palsy 30.4 PLP1 KANK1 ELOVL4 ARG1 ALDH3A2
8 sjogren-larsson syndrome 30.1 ELOVL4 ALDH3A2
9 spastic diplegia 30.0 SLC16A2 ATP1A3 ARG1 ALDH3A2
10 cranial nerve palsy 29.7 SDHD MOG
11 transverse myelitis 29.5 MOG CCR6
12 miller fisher syndrome 29.3 MOG CCR6
13 acute disseminated encephalomyelitis 29.2 MOG CCR6
14 ichthyosis, spastic quadriplegia, and mental retardation 11.5
15 spastic tetraplegia and axial hypotonia, progressive 11.5
16 halperin-birk syndrome 11.5
17 neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures 11.4
18 absent eyebrows and eyelashes with mental retardation 11.3
19 locked-in syndrome 11.2
20 microcephaly with spastic quadriplegia 11.2
21 neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss 11.1
22 spastic tetraplegia-retinitis pigmentosa-intellectual disability syndrome 11.1
23 oculocerebral syndrome with hypopigmentation 11.0
24 neurodevelopmental disorder with motor and speech delay and behavioral abnormalities 11.0
25 developmental and epileptic encephalopathy 4 11.0
26 developmental and epileptic encephalopathy 5 11.0
27 spinal cord injury 11.0
28 alternating hemiplegia of childhood 1 11.0
29 spastic paraplegia 16, x-linked 11.0
30 alternating hemiplegia of childhood 2 11.0
31 asparagine synthetase deficiency 11.0
32 developmental and epileptic encephalopathy 53 11.0
33 developmental and epileptic encephalopathy 55 11.0
34 leukodystrophy, hypomyelinating, 20 11.0
35 pontocerebellar hypoplasia, type 14 11.0
36 pontocerebellar hypoplasia, type 15 11.0
37 paraplegia 11.0
38 spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly synd 10.9
39 diencephalic-mesencephalic junction dysplasia syndrome 1 10.9
40 spastic quadriplegia, retinitis pigmentosa, and mental retardation 10.9
41 spastic tetraplegia, thin corpus callosum, and progressive microcephaly 10.9
42 congenital ichthyosis-microcephalus-tetraplegia syndrome 10.9
43 inherited congenital spastic tetraplegia 10.9
44 neurodegeneration with brain iron accumulation 2a 10.9
45 hsd10 mitochondrial disease 10.9
46 cortical dysplasia, complex, with other brain malformations 7 10.9
47 spinal muscular atrophy, distal, autosomal recessive, 4 10.9
48 cortical dysplasia, complex, with other brain malformations 4 10.9
49 spastic ataxia 8, autosomal recessive, with hypomyelinating leukodystrophy 10.9
50 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.9

Graphical network of the top 20 diseases related to Quadriplegia:



Diseases related to Quadriplegia

Symptoms & Phenotypes for Quadriplegia

UMLS symptoms related to Quadriplegia:


muscle weakness; ophthalmoplegia; hemiplegia; quadriparesis; other quadriplegia

GenomeRNAi Phenotypes related to Quadriplegia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.19 ABCB6 ALDH3A2 ARG1 ATP1A2 ATP1A3 CCR6
2 no effect GR00402-S-2 10.19 ABCB6 ALDH3A2 ARG1 ATP1A2 ATP1A3 CCR6

MGI Mouse Phenotypes related to Quadriplegia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.13 ALDH3A2 ARG1 ATP1A2 ATP1A3 CCR6 ELOVL4
2 homeostasis/metabolism MP:0005376 10.06 ABCB6 ALDH3A2 ARG1 ATP1A2 ATP1A3 CCR6
3 behavior/neurological MP:0005386 9.73 ALDH3A2 ATP1A2 ATP1A3 ELOVL4 GEMIN4 MOG
4 mortality/aging MP:0010768 9.53 ABCB6 ALDH3A2 ARG1 ATP1A2 ATP1A3 ELOVL4

Drugs & Therapeutics for Quadriplegia

Drugs for Quadriplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
2
Tannic acid Approved Phase 4 1401-55-4 16129878 16129778
3
Midodrine Approved Phase 4 133163-28-7, 42794-76-3 4195
4
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
5 Anesthetics Phase 4
6 Anesthetics, General Phase 4
7 Omega 3 Fatty Acid Phase 4
8 Neurotransmitter Agents Phase 4
9 Adrenergic alpha-Agonists Phase 4
10 Adrenergic Agonists Phase 4
11 Adrenergic Agents Phase 4
12 Vasoconstrictor Agents Phase 4
13 Sympathomimetics Phase 4
14
Nitric Oxide Approved Phase 2, Phase 3 10102-43-9 145068
15
Arginine Approved, Investigational, Nutraceutical Phase 2, Phase 3 74-79-3 6322
16 NG-Nitroarginine Methyl Ester Phase 2, Phase 3
17
Buspirone Approved, Investigational Phase 1, Phase 2 36505-84-7 2477
18 Anti-Anxiety Agents Phase 1, Phase 2
19 Psychotropic Drugs Phase 1, Phase 2
20 Serotonin Receptor Agonists Phase 1, Phase 2
21
Serotonin Investigational, Nutraceutical Phase 1, Phase 2 50-67-9 5202
22
Tiotropium Approved Phase 1 136310-93-5, 186691-13-4 3086655 5487427 5487426
23
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 1 55-56-1 2713 9552079
24 Bronchodilator Agents Phase 1
25 Anti-Asthmatic Agents Phase 1
26 Respiratory System Agents Phase 1
27 Cholinergic Antagonists Phase 1
28 Cholinergic Agents Phase 1
29 Parasympatholytics Phase 1
30 Bromides Phase 1
31 Adrenergic beta-Agonists Phase 1
32
Salmeterol Xinafoate Phase 1 94749-08-3
33 Chlorhexidine gluconate Phase 1
34 Antioxidants Phase 1
35 Hemostatics Phase 1
36 Protective Agents Phase 1
37 Papaya Approved
38
Mometasone furoate Approved, Investigational, Vet_approved 83919-23-7 4240 441336
39
Ipratropium Approved, Experimental 22254-24-6, 60205-81-4 657309 3746
40
Enalaprilat Approved 76420-72-9 6917719 5462501
41
Enalapril Approved, Vet_approved 75847-73-3 40466924 5388962 5362032
42
Silicon Approved, Investigational 7440-21-3 4082203
43
Metronidazole Approved 443-48-1, 69198-10-3 4173
44 Insulin, Globin Zinc
45
Insulin
46 Vitamins
47 Whey Protein
48 Antihypertensive Agents
49 Angiotensin-Converting Enzyme Inhibitors
50 HIV Protease Inhibitors

Interventional clinical trials:

(show top 50) (show all 130)
# Name Status NCT ID Phase Drugs
1 Early Nerve Reconstruction Approach in Tetraplegic Patients With Dysfunctional Upper Extremity: a Randomized Controlled Trial. Unknown status NCT01579604 Phase 4
2 A Longitudinal Clinical Feasibility Study to Evaluate the Psychological and Functional Effects of Using the Tobii™ Eyegaze System by Inpatients With Tetraplegia Unknown status NCT01943656 Phase 4
3 Omega-3 Supplementation to Increase HDL-c Levels in Those With Tetraplegia Completed NCT01896037 Phase 4
4 Melatonin Replacement for Treatment of Sleep Disruption Completed NCT00507546 Phase 4 Ramelteon;Placebo
5 Core Temperature During Cold Exposure in Persons With Tetraplegia Completed NCT01822535 Phase 4 Midodrine hydrochloride
6 Phrenic Reinnervation in Central Ventilatory Paralysis Due to Medullary Trauma With Phrenic Motoneuron Destruction Completed NCT01350297 Phase 4
7 Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia Active, not recruiting NCT02379156 Phase 4 Midodrine Hydrochloride
8 Activity-Dependent Plasticity After Spinal Cord Injury Unknown status NCT00059553 Phase 2, Phase 3
9 Evaluation of the Efficacy of "MEOPA" Used to Obtain Better ROM Immediately After Multilevel Surgery in Children With Spastic Diplegia, Quadriplegia or Hemiplegia. Completed NCT00632528 Phase 3 MEOPA;Medicinal air
10 Outcome Evaluation of Exercise and Electrical Therapy for Quadriplegic Hand Function Completed NCT00656149 Phase 2, Phase 3
11 The Effect of Nitric Oxide on Pulmonary Resistances and Blood Pressure in Persons With Tetraplegia Completed NCT00753948 Phase 2, Phase 3 N-Nitro L-arginine-methylester (L-NAME)
12 Prevention of Low Blood Pressure in Persons With Tetraplegia Completed NCT00237770 Phase 2, Phase 3 N-Nitro L-arginine-methylester (L-NAME)
13 Improving Hand Function in Chronic SCI With Combined Robotic Training and tDCS Active, not recruiting NCT03555838 Phase 3
14 Randomised Open Study of the Efficiency and Tolerance of the Use of a Corset on the Respiratory Function of Spinal Cord Injury Patients Withdrawn NCT01569360 Phase 3
15 ASIA Motor, Functional and Health Related Quality of Life Outcome in Traumatic Central Cord Syndrome, a Prospective Randomized Study Unknown status NCT00475748 Phase 2
16 Safety and Efficacy of L-NAME and Midodrine to Increase MAP in Persons With Tetraplegia Completed NCT00835224 Phase 2 L-NAME;Midodrine;Placebo
17 Rehabilitation and Cortical Remodeling After Surgical Intervention for Spinal Cord Injury Recruiting NCT04041063 Phase 2
18 Enabling Forelimb Function With Agonist Drug and Epidural Stimulation in SCI Active, not recruiting NCT02313194 Phase 1, Phase 2 Buspirone
19 Rehabilitation of the Lower Extremity With AMES Following Incomplete Spinal Cord Injury (SCI) Terminated NCT01498991 Phase 1, Phase 2
20 Effect of Two Different Air-stacking Techniques, Combined With Manually Assisted Cough, on Peak Cough Flow (PCF) in Patients With Acute Cervical or High Thoracic Spinal Cord Injury Withdrawn NCT01046175 Phase 2
21 Improving Ambulatory Community Access After Paralysis Unknown status NCT01570816 Phase 1
22 Acute and Chronic Effects of an Anticholinergic Agent or a Long-Acting Beta 2 Agonist on Levels of Exhaled Nitric Oxide and Pulmonary Function in Persons With Tetraplegia Unknown status NCT01355991 Phase 1 Tiotropium;Salmeterol
23 The Safety of Autologous Human Schwann Cells (ahSC) in Subjects With Chronic Spinal Cord Injury (SCI) Receiving Rehabilitation Completed NCT02354625 Phase 1
24 Development and Translational Assessment of a Tongue-Based Assistive Neuro-Technology for Individuals With Severe Neurological Disorders Completed NCT01124292 Phase 1
25 The Role of Melatonin in the Regulation of Blood Coagulation Completed NCT01741389 Phase 1 Melatonin ("Circadin")
26 Use of Interactive Gaming After Spinal Cord Injury Completed NCT01537978 Phase 1
27 Clinical Evaluation of Brain-Computer Interface for Helping Communication of Quadriplegic Patients Unknown status NCT01707498
28 Development of a Spinal Cord Injury-specific Exercise-based Capacity Unknown status NCT02602639
29 Brain Computer Interface Based Communication in the Completely Locked-In State Unknown status NCT02980380
30 Developing Strategies to Optimize the Exercise Response in Persons Living With Tetraplegia. Unknown status NCT04465825
31 Body Composition Assessment in Spinal Cord Injury Unknown status NCT00957762
32 Abdominal Functional Electrical Stimulation to Augment Breathing in Tetraplegia Unknown status NCT00202631
33 A Randomized, Crossover Clinical Trial of Exoskeletal-assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons With SCI Unknown status NCT02314221
34 Functional Electrical Stimulation Cycling in Acute Spinal Cord Injury; a Feasibility Study Unknown status NCT04064385
35 A Clinical Observational Follow-up Study of European Pediatric Cases of Acute Flaccid Myelitis Associated With EV-D68 Infection. Unknown status NCT03499366
36 A Feasibility Study of the Ability of the Neural Prosthetic System to Provide Direct Brain Control of Extracorporeal Devices in Patients With Quadriplegia Due to High Spinal Cord Injury Completed NCT01849822
37 Reanimation in Tetraplegia: Restoring Cortical Control of Functional Movement in Humans With Quadriplegia Completed NCT01997125
38 Finding the Optimal Voluntary Exercise Parameters for Generating a Health Benefit in Those Living With Quadriplegia Completed NCT03146728
39 Intermittent Theta Burst Stimulation to Promote Motor Re-education After Upper Limb Reconstruction in Tetraplegia Completed NCT03277521
40 Cardiovascular Parameters for Lokomat Training in Chronic Incomplete SCI Completed NCT00385918
41 Study of the Surgical Treatment of Cervical Spinal Cord Injuries With Nerve Transfers to Restore Upper Extremity and Hand Function Completed NCT01899664
42 Functional Evaluation of the Recovery of Prehension in Quadriplegics by Implanted Neural Stimulation Completed NCT04306328
43 Effectiveness of Standing Frame on Constipation in Children With Cerebral Palsy: a Single Subject Study Completed NCT01911559
44 Exercise to Reduce Obesity in Spinal Cord Injury Completed NCT00270855
45 Prospective Comparative Multicenter Study on the Medico-economical Impact of the Brindley Technique in the Management of Neurogenic Bladder in Patients With Injured Spinal Cord Completed NCT00221767
46 Multi-Center Pivotal Study of NeuRx RA/4 Ventilatory Assist Device Completed NCT00010374
47 Feasibility Study of the mindBEAGLE Device in Patients With Disorders of Consciousness or Locked-In Syndrome Completed NCT02772302
48 Electrical Stimulation in Denervated Muscles of the Upper Limbs - Effect on Muscle Morphological Properties - A Pilot Study Completed NCT03698136
49 Random Noise Stimulation to Enhance Corticomotor Drive for Improved Hand Function Completed NCT04777149
50 Conditioning Neural Circuits to Improve Upper Extremity Function Completed NCT02611375

Search NIH Clinical Center for Quadriplegia

Cochrane evidence based reviews: quadriplegia

Genetic Tests for Quadriplegia

Genetic tests related to Quadriplegia:

# Genetic test Affiliating Genes
1 Tetraplegia 28

Anatomical Context for Quadriplegia

Organs/tissues related to Quadriplegia:

MalaCards : Spinal Cord, Brain, Tongue, Cortex, Medulla Oblongata, Heart, Bone

Publications for Quadriplegia

Articles related to Quadriplegia:

(show top 50) (show all 6350)
# Title Authors PMID Year
1
Sjögren-larsson syndrome: a study of clinical symptoms and dermatological treatment in 34 Swedish patients. 53 62
19197545 2009
2
[Clinical consequences of neuromuscular impairments in critically ill patients]. 53 62
16768037 2006
3
[An autopsied case of schizophrenic patient who died from heat stroke]. 53 62
16780054 2006
4
Adeno-associated virus vectors are able to restore fatty aldehyde dehydrogenase-deficiency. Implications for gene therapy in Sjogren-Larsson syndrome. 53 62
15834613 2005
5
Update on Sjögren-Larsson syndrome. 53 62
8884139 1996
6
[Etiological aspects of orthostatic hypotension]. 53 62
1344926 1992
7
Australian arm of the International Spinal Cord Injury (Aus-InSCI) Community Survey: 2. Understanding the lived experience in people with spinal cord injury. 62
35705701 2022
8
Level of injury is an independent determining factor of gut dysbiosis in people with chronic spinal cord injury: A cross-sectional study. 62
35835855 2022
9
Epidemiology of spinal cord injury in China: A systematic review of the chinese and english literature. 62
35778501 2022
10
Insights on the Potential Mechanisms of Action of Functional Electrical Stimulation Therapy in Combination With Task-Specific Training: A Scoping Review. 62
34031937 2022
11
Status Epilepticus Related Takotsubo Syndrome - A Case Report. 62
35470412 2022
12
A mouse-adapted CVA6 strain exhibits neurotropism and triggers systemic manifestations in a novel murine model. 62
36036059 2022
13
Pancreatitis in the Complex Care Population: Presentation, Incidence, and Severity. 62
36084229 2022
14
Posttraumatic locked-in syndrome from combined brainstem and upper cervical injury in childhood: A case report. 62
35644290 2022
15
Spontaneous spinal cord infarction: a practical approach. 62
35835550 2022
16
Reproducibility, Construct Validity, and Responsiveness of the Tetraplegia Upper Limb Activities Questionnaire, TUAQ. Part 2. 62
35595067 2022
17
Predicting strength outcomes for upper limb nerve transfer surgery in tetraplegia. 62
35923066 2022
18
Quantifying Donor Deficits Following Nerve Transfer Surgery in Tetraplegia. 62
36257880 2022
19
Upper Limb Nerve Transfer Surgery in Patients With Tetraplegia. 62
36441549 2022
20
The detection and sensory perception of inspiratory resistive loads in people with chronic tetraplegia. 62
36107987 2022
21
Vital sign differences between septic patients with tetraplegia and paraplegia. 62
36433952 2022
22
Development, Internal Construct, and Unidimensionality of the Tetraplegia Upper Limb Activities Questionnaire, TUAQ. Part 1. 62
35595068 2022
23
Use and evaluation of assistive technologies for upper limb function in tetraplegia. 62
33606599 2022
24
The influence of psychological need on rehabilitation outcomes for people with spinal cord injury. 62
36435913 2022
25
Physical and emotional consequences of excess weight as experienced by individuals with spinal cord injuries. 62
36448929 2022
26
Adherence to long-term medical follow-up: A qualitative, experience-focused study of people with spinal cord injury. 62
35031498 2022
27
Rasch Analysis of the International Quality of Life Basic Data Set Version 2.0. 62
35314170 2022
28
Post-operative Incomplete Quadriplegia Caused by Conversion Disorder in a Female After Gynecological Surgery: A Case Report. 62
36475213 2022
29
Quadriplegia from cervical osteomyelodiscitis with vertebral collapse: A case report. 62
36408081 2022
30
Refractory status epilepticus with fever due to mumps vaccine-induced encephalitis caused secondary encephalopathy mimicking acute encephalopathy with biphasic seizures and late reduced diffusion. 62
36030148 2022
31
Traumatic posterior atlantoaxial dislocation without fracture of the odontoid process: illustrative case. 62
36345203 2022
32
Accidental boosting in an individual with tetraplegia - considerations for the interpretation of cardiopulmonary exercise testing. 62
33513073 2022
33
Developing guiding principles for technology-based rehabilitation program by engaging people with motor incomplete tetraplegia. 62
36424612 2022
34
Multisensory stimulation and rehabilitation for disability improvement: Lessons from a case report. 62
36401482 2022
35
How did intraoperative neuromonitorization prevent tetraplegia? 62
36400977 2022
36
Acute quadriplegia and epileptic seizures in a 47-year-old man. 62
36427895 2022
37
Beyond the caudate nucleus: Early atypical neuroimaging findings in biotin-thiamine- responsive basal ganglia disease. 62
35811190 2022
38
An association study of IL2RA polymorphisms with cerebral palsy in a Chinese population. 62
36195861 2022
39
The Profile of Epilepsy and its characteristics in Children with Cerebral Palsy. 62
36070632 2022
40
Dorsal rhizotomy in cerebral palsy: How root sectioning is influenced by intraoperative neuromonitoring? 62
35150726 2022
41
PSMC1 variant causes a novel neurological syndrome. 62
35861243 2022
42
Robotic Walking to Mitigate Bone Mineral Density Decline and Adverse Body Composition in Individuals With Incomplete Spinal Cord Injury: A Pilot Randomized Clinical Trial. 62
34864766 2022
43
White Cord Syndrome: A Reperfusion Injury Following Spinal Decompression Surgery. 62
36381466 2022
44
Spinal Cord Infarction Presenting as Right-Sided Upper Back Pain: A Case Report. 62
36381910 2022
45
Medical Liability in Obstetrics/Gynecology and Co-liability With Anesthesiology in Greece: A Retrospective Study. 62
36465757 2022
46
Comprehensive Rehabilitation of Post-Operative Paraplegic Patient: A Case Report. 62
36415421 2022
47
Mild Encephalopathy/Encephalitis With a Reversible Splenial Lesion (MERS) and Longitudinally Extensive Transverse Myelitis (LETM) in Influenza B: Neurotropic Mechanisms and Diagnostic Challenges. 62
36426329 2022
48
Primary Spinal Glioblastoma Mimicking Neuroschistosomiasis: A Case Report. 62
36381781 2022
49
Mechanomyography and tissue oxygen saturation during electrically-evoked wrist extensor fatigue in people with tetraplegia. 62
35662061 2022
50
Activating effective functional hand movements in individuals with complete tetraplegia through neural stimulation. 62
36202865 2022

Variations for Quadriplegia

Expression for Quadriplegia

Search GEO for disease gene expression data for Quadriplegia.

Pathways for Quadriplegia

Pathways related to Quadriplegia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.07 PLP1 MOG

GO Terms for Quadriplegia

Cellular components related to Quadriplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial envelope GO:0005740 9.26 SDHD ABCB6
2 sodium:potassium-exchanging ATPase complex GO:0005890 8.92 ATP1A3 ATP1A2

Biological processes related to Quadriplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.46 ATP1A3 ATP1A2
2 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP1A3 ATP1A2
3 response to glycoside GO:1903416 8.92 ATP1A3 ATP1A2

Molecular functions related to Quadriplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-type sodium:potassium-exchanging transporter activity GO:0005391 9.46 ATP1A3 ATP1A2
2 steroid hormone binding GO:1990239 9.26 ATP1A3 ATP1A2
3 P-type potassium transmembrane transporter activity GO:0008556 8.62 ATP1A3 ATP1A2

Sources for Quadriplegia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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