Aliases & Classifications for Quadriplegia

MalaCards integrated aliases for Quadriplegia:

Name: Quadriplegia 12 75 15 17 72
Tetraplegia 12 29 15
Tetraplegias 55

Classifications:



External Ids:

Disease Ontology 12 DOID:12835
ICD9CM 35 344.00
MeSH 44 D011782
NCIt 50 C50721
SNOMED-CT 68 11538006
ICD10 33 G82.5 G82.50
UMLS 72 C0034372

Summaries for Quadriplegia

MalaCards based summary : Quadriplegia, also known as tetraplegia, is related to spastic quadriplegia and spastic cerebral palsy, and has symptoms including muscle weakness, ophthalmoplegia and hemiplegia. An important gene associated with Quadriplegia is ELOVL4 (ELOVL Fatty Acid Elongase 4), and among its related pathways/superpathways are Carbon metabolism and Endocrine and other factor-regulated calcium reabsorption. The drugs Acetylcholine and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and testes, and related phenotypes are behavior/neurological and hematopoietic system

Wikipedia : 75 Tetraplegia, also known as quadriplegia, is paralysis caused by illness or injury that results in the... more...

Related Diseases for Quadriplegia

Diseases related to Quadriplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 464)
# Related Disease Score Top Affiliating Genes
1 spastic quadriplegia 31.7 WDR45B SPTAN1 SDHD SDHAF1 SDHA PLP1
2 spastic cerebral palsy 31.6 WDR45B PLP1 ALDH3A2
3 mitochondrial complex ii deficiency 30.8 SDHD SDHAF1 SDHA
4 kearns-sayre syndrome 28.8 SDHD SDHAF1 SDHA
5 ichthyosis, spastic quadriplegia, and mental retardation 12.7
6 neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures 12.6
7 microcephaly with spastic quadriplegia 12.3
8 spastic quadriplegia, retinitis pigmentosa, and mental retardation 12.2
9 locked-in syndrome 11.9
10 absent eyebrows and eyelashes with mental retardation 11.7
11 spinal cord injury 11.5
12 inherited congenital spastic tetraplegia 11.5
13 paraplegia 11.5
14 leukodystrophy, hypomyelinating, 6 11.4
15 epileptic encephalopathy, early infantile, 4 11.4
16 epileptic encephalopathy, early infantile, 5 11.4
17 pelizaeus-merzbacher disease 11.4
18 alternating hemiplegia of childhood 1 11.2
19 alternating hemiplegia of childhood 2 11.2
20 epileptic encephalopathy, early infantile, 53 11.2
21 8p inverted duplication/deletion syndrome 11.2
22 oculocerebral syndrome with hypopigmentation 11.2
23 hsd10 mitochondrial disease 11.2
24 cortical dysplasia, complex, with other brain malformations 4 11.2
25 microcephaly, seizures, spasticity, and brain calcifications 11.2
26 spastic tetraplegia, thin corpus callosum, and progressive microcephaly 11.2
27 spastic tetraplegia-retinitis pigmentosa-intellectual disability syndrome 11.2
28 spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome 11.2
29 congenital ichthyosis-microcephalus-tetraplegia syndrome 11.2
30 variegate porphyria 11.1
31 argininemia 11.1
32 farber lipogranulomatosis 11.1
33 sulfite oxidase deficiency, isolated 11.1
34 allan-herndon-dudley syndrome 11.1
35 cerebral palsy, spastic quadriplegic, 2 11.1
36 asparagine synthetase deficiency 11.1
37 encephalopathy, progressive, early-onset, with brain atrophy and thin corpus callosum 11.1
38 immunodeficiency 49 11.1
39 rab18 deficiency 11.1
40 encephalocele 11.1
41 familial glucocorticoid deficiency 11.1
42 spastic paraplegia 16 11.1
43 cerebral palsy 10.3
44 hypokalemia 10.3
45 spasticity 10.3
46 mental retardation with spastic paraplegia and palmoplantar hyperkeratosis 10.3
47 ocular motor apraxia 10.3
48 spinal stenosis 10.3
49 respiratory failure 10.2
50 epidural abscess 10.2

Graphical network of the top 20 diseases related to Quadriplegia:



Diseases related to Quadriplegia

Symptoms & Phenotypes for Quadriplegia

UMLS symptoms related to Quadriplegia:


muscle weakness, ophthalmoplegia, hemiplegia, quadriparesis, other quadriplegia

MGI Mouse Phenotypes related to Quadriplegia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 ALDH3A2 ATP1A2 ATP1A3 BCL11B ELOVL4 PLP1
2 hematopoietic system MP:0005397 9.86 ALDH3A2 ARG1 ATP1A3 BCL11B ELOVL4 PIK3C2A
3 homeostasis/metabolism MP:0005376 9.85 ALDH3A2 ARG1 ATP1A2 ATP1A3 BCL11B ELOVL4
4 mortality/aging MP:0010768 9.65 ARG1 ATP1A2 ATP1A3 BCL11B ELOVL4 PIK3C2A
5 nervous system MP:0003631 9.23 ALDH3A2 ARG1 ATP1A2 ATP1A3 ELOVL4 PLP1

Drugs & Therapeutics for Quadriplegia

Drugs for Quadriplegia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 109)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
3
Midodrine Approved Phase 4 133163-28-7, 42794-76-3 4195
4
Norepinephrine Approved Phase 4 51-41-2 439260
5
Droxidopa Approved, Investigational Phase 4 23651-95-8 443940
6
Baclofen Approved Phase 4 1134-47-0 2284
7
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
8 Antioxidants Phase 4
9 Protective Agents Phase 4
10 Omega 3 Fatty Acid Phase 4
11 Vasodilator Agents Phase 4
12 Cholinergic Agents Phase 4
13 abobotulinumtoxinA Phase 4
14 Neuromuscular Agents Phase 4
15 Acetylcholine Release Inhibitors Phase 4
16 Botulinum Toxins Phase 4
17 Botulinum Toxins, Type A Phase 4
18 Phosphodiesterase Inhibitors Phase 4
19 Phosphodiesterase 5 Inhibitors Phase 4
20 Neurotransmitter Agents Phase 4
21 Peripheral Nervous System Agents Phase 4
22 Autonomic Agents Phase 4
23 Sympathomimetics Phase 4
24 Adrenergic Agonists Phase 4
25 Adrenergic alpha-Agonists Phase 4
26 Adrenergic Agents Phase 4
27 Vasoconstrictor Agents Phase 4
28 Anesthetics, General Phase 4
29 Antihypertensive Agents Phase 4
30 Antiparkinson Agents Phase 4
31
Fenofibrate Approved Phase 2, Phase 3 49562-28-9 3339
32
4-Aminopyridine Approved Phase 3 504-24-5 1727
33
Nitroarginine Experimental, Investigational Phase 2, Phase 3 2149-70-4
34 Free Radical Scavengers Phase 2, Phase 3
35 NG-Nitroarginine Methyl Ester Phase 2, Phase 3
36 arginine Phase 2, Phase 3
37 Endothelium-Dependent Relaxing Factors Phase 2, Phase 3
38 Lipid Regulating Agents Phase 2, Phase 3
39 Hypolipidemic Agents Phase 2, Phase 3
40 Antimetabolites Phase 2, Phase 3
41 Potassium Channel Blockers Phase 3
42
Dopamine Approved Phase 1, Phase 2 51-61-6, 62-31-7 681
43
Levodopa Approved Phase 1, Phase 2 59-92-7 6047
44
Carbidopa Approved Phase 1, Phase 2 28860-95-9 34359
45
Buspirone Approved, Investigational Phase 1, Phase 2 36505-84-7 2477
46
Nitric Oxide Approved Phase 2 10102-43-9 145068
47 Central Nervous System Depressants Phase 1, Phase 2
48 Dopamine Agents Phase 1, Phase 2
49 Serotonin Receptor Agonists Phase 1, Phase 2
50 Tranquilizing Agents Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 191)
# Name Status NCT ID Phase Drugs
1 A Longitudinal Clinical Feasibility Study to Evaluate the Psychological and Functional Effects of Using the Tobii™ Eyegaze System by Inpatients With Tetraplegia Unknown status NCT01943656 Phase 4
2 Phrenic Reinnervation in Central Ventilatory Paralysis Due to Medullary Trauma With Phrenic Motoneuron Destruction Completed NCT01350297 Phase 4
3 Melatonin Replacement for Treatment of Sleep Disruption Completed NCT00507546 Phase 4 Ramelteon;Placebo
4 Omega-3 Supplementation to Increase HDL-c Levels in Those With Tetraplegia Completed NCT01896037 Phase 4
5 Core Temperature During Cold Exposure in Persons With Tetraplegia Completed NCT01822535 Phase 4 Midodrine hydrochloride
6 Botulinum Toxin A for the Treatment of Cervical/Shoulder Pain Following Acute Spinal Cord Injury. Completed NCT00320281 Phase 4 botulinum toxin A
7 A Randomized, Double-blind, Placebo-controlled Cross-over Trial Assessing the Effect of Tadalafil (Cialis) on the Cardiovascular System in Men With Complete Spinal Cord Injury (SCI) at or Above the Sixth Thoracic Level Completed NCT01067391 Phase 4 tadalafil;placebo
8 Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia Recruiting NCT02379156 Phase 4 Midodrine Hydrochloride
9 Early Nerve Reconstruction Approach in Tetraplegic Patients With Dysfunctional Upper Extremity: a Randomized Controlled Trial. Recruiting NCT01579604 Phase 4
10 Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury Recruiting NCT03602014 Phase 4 Northera
11 Does Oral Baclofen Improve Care and Comfort in Spastic Children in Nursing Homes? Terminated NCT00752934 Phase 4 oral baclofen + placebo;placebo + oral baclofen
12 Restoration of Upper Limb Function in Individuals With Sub-Acute Spinal Cord Injury Unknown status NCT01292811 Phase 3
13 SCIPA (Spinal Cord Injury and Physical Activity) Hands-On: Early Intensive Hand Rehabilitation After Spinal Cord Injury Unknown status NCT01086930 Phase 3
14 Activity-Dependent Plasticity After Spinal Cord Injury Unknown status NCT00059553 Phase 2, Phase 3
15 Prevention of Low Blood Pressure in Persons With Tetraplegia Completed NCT00237770 Phase 2, Phase 3 N-Nitro L-arginine-methylester (L-NAME)
16 The Effect of Nitric Oxide on Pulmonary Resistances and Blood Pressure in Persons With Tetraplegia Completed NCT00753948 Phase 2, Phase 3 N-Nitro L-arginine-methylester (L-NAME)
17 Evaluation of the Efficacy of "MEOPA" Used to Obtain Better ROM Immediately After Multilevel Surgery in Children With Spastic Diplegia, Quadriplegia or Hemiplegia. Completed NCT00632528 Phase 3 MEOPA;Medicinal air
18 Outcome Evaluation of Exercise and Electrical Therapy for Quadriplegic Hand Function Completed NCT00656149 Phase 2, Phase 3
19 Improving Hand Function in Chronic SCI With Combined Robotic Training and tDCS Completed NCT03555838 Phase 3
20 Evaluation of Systemic Hypothermia Initiated After 6 Hours of Age in Infants ≥36 Weeks Gestation With Hypoxic-Ischemic Encephalopathy: A Bayesian Evaluation. A Protocol for the NICHD Neonatal Research Network Completed NCT00614744 Phase 2, Phase 3
21 An Open Label Safety and Efficacy Trial of Fenofibrate in Persons With SCI Completed NCT02455336 Phase 2, Phase 3 Fenofibrate
22 Quality of Life, Efficacy and Safety of High Doses of 4-aminopyridine in Patients With Clinically Complete Chronic Spinal Cord Injury: Multicenter, Randomized, Double Blind, Placebo Controlled Clinical Trial Not yet recruiting NCT03899584 Phase 3 4-Aminopyridine;Placebo oral capsule
23 Optimizing Cooling Strategies at < 6 Hours of Age for Neonatal Hypoxic-Ischemic Encephalopathy Terminated NCT01192776 Phase 3
24 A Phase II/III, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Cethrin in Subjects With Acute Cervical Spinal Cord Injury Withdrawn NCT02053883 Phase 2, Phase 3 Cethrin (BA-210);Placebo
25 Randomised Open Study of the Efficiency and Tolerance of the Use of a Corset on the Respiratory Function of Spinal Cord Injury Patients Withdrawn NCT01569360 Phase 3
26 ASIA Motor, Functional and Health Related Quality of Life Outcome in Traumatic Central Cord Syndrome, a Prospective Randomized Study Unknown status NCT00475748 Phase 2
27 A Phase 1/2a Dose Escalation Study of AST-OPC1 in Subjects With Subacute Cervical Spinal Cord Injury Completed NCT02302157 Phase 1, Phase 2
28 Safety and Efficacy of L-NAME and Midodrine to Increase MAP in Persons With Tetraplegia Completed NCT00835224 Phase 2 L-NAME;Midodrine;Placebo
29 A Phase I/IIa Dose-Ranging Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BA-210 and the Neurological Status of Patients Following Administration of a Single Extradural Application of Cethrin During Surgery for Acute Thoracic and Cervical Spinal Cord Injury Completed NCT00500812 Phase 1, Phase 2 Cethrin
30 Electrical Stimulation Induced Lower Limb Exercise Capacity, Cardiorespiratory Response, Cardiovascular Risk Factors and Muscle Activity Patterns in Response to Robotic Assisted Treadmill Gait Training in Individuals With Complete Motor Spinal Cord Injury Completed NCT01349478 Phase 1, Phase 2
31 FES Therapy:Restoring Voluntary Grasping Function in Chronic SCI Completed NCT01208688 Phase 2
32 Tri-therapy (SPINALON)-Elicited Spinal Locomotor Network Activation: Phase I-IIa Clinical Trial in Patients With Chronic Spinal Cord Injury Completed NCT01484184 Phase 1, Phase 2 SPINALON (buspirone + levodopa + cardidopa)
33 A Dose Response Trial Using 5 and 10 mg. of Midodrine Hydrochloride to Treat Orthostatic Hypotension in Persons With SCI Completed NCT00426842 Phase 2 Midodrine Hydrochloride
34 Neurodevice Phase II: Wireless Implantable Neurodevice Microsystem for Neuroprosthesis and Neuroscience Recruiting NCT03811301 Phase 2
35 Rehabilitation and Cortical Remodeling After Surgical Intervention for Spinal Cord Injury Recruiting NCT04041063 Phase 2
36 Enabling Forelimb Function With Agonist Drug and Epidural Stimulation in SCI Recruiting NCT02313194 Phase 1, Phase 2
37 Antibodies Against Nogo-A to Enhance Plasticity, Regeneration and Functional Recovery After Spinal Cord Injury - A Multicenter International Randomized Double Blind Placebo Controlled Phase II Clinical Proof of Concept Trial Recruiting NCT03935321 Phase 2 NG-101;Placebos
38 Exoskeleton Training After Spinal Cord Injury Recruiting NCT03410550 Phase 2
39 The Effect of Intrathecal Transplantation of Umbilical Cord Mesenchymal Stem Cells in Patients With Late Stage of Chronic Spinal Cord Injury:A Multicenter, Prospective, Cohort Study Recruiting NCT03505034 Phase 2 Umbilical Cord Mesenchymal Stem Cells
40 The Effect of Intrathecal Transplantation of Umbilical Cord Mesenchymal Stem Cells in Patients With Sub-Acute Spinal Cord Injury:A Multicenter, Randomized, Controlled Trial Recruiting NCT03521336 Phase 2 Umbilical Cord Mesenchymal Stem Cells;Placebo
41 The Effect of Intrathecal Transplantation of Umbilical Cord Mesenchymal Stem Cells in Patients With Early Stage of Chronic Spinal Cord Injury:A Multicenter, Randomized, Controlled Trial Recruiting NCT03521323 Phase 2 Umbilical Cord Mesenchymal Stem Cells;Placebos
42 A Randomized, Double-blind, Placebo-controlled Trial to Determine the Effects and Duration of Action of Tiotropium Bromide on Pulmonary Function in Persons With SCI Enrolling by invitation NCT02586649 Phase 2 Tiotropium Bromide;Placebo
43 A Phase II Multicenter, Randomized-Controlled Study to Evaluate the Safety and Efficacy of Autologous Incubated Macrophages for the Treatment of Patients With Complete Spinal Cord Injuries Suspended NCT00073853 Phase 2
44 Rehabilitation of the Lower Extremity With AMES Following Incomplete Spinal Cord Injury (SCI) Terminated NCT01498991 Phase 1, Phase 2
45 Effect of Two Different Air-stacking Techniques, Combined With Manually Assisted Cough, on Peak Cough Flow (PCF) in Patients With Acute Cervical or High Thoracic Spinal Cord Injury Withdrawn NCT01046175 Phase 2
46 Acute and Chronic Effects of an Anticholinergic Agent or a Long-Acting Beta 2 Agonist on Levels of Exhaled Nitric Oxide and Pulmonary Function in Persons With Tetraplegia Unknown status NCT01355991 Phase 1 Tiotropium;Salmeterol
47 Acute and Chronic Effects of Inhaled Steroids on Pulmonary Function in Persons With Spinal Cord Injury Unknown status NCT01353599 Phase 1 Mometasone furoate
48 The Role of Melatonin in the Regulation of Blood Coagulation Completed NCT01741389 Phase 1 Melatonin ("Circadin")
49 Use of Interactive Gaming After Spinal Cord Injury Completed NCT01537978 Phase 1
50 The Safety of Autologous Human Schwann Cells (ahSC) in Subjects With Chronic Spinal Cord Injury (SCI) Receiving Rehabilitation Completed NCT02354625 Phase 1

Search NIH Clinical Center for Quadriplegia

Genetic Tests for Quadriplegia

Genetic tests related to Quadriplegia:

# Genetic test Affiliating Genes
1 Tetraplegia 29

Anatomical Context for Quadriplegia

MalaCards organs/tissues related to Quadriplegia:

41
Spinal Cord, Brain, Testes, Bone, Heart, Tongue, Lung

Publications for Quadriplegia

Articles related to Quadriplegia:

(show top 50) (show all 5582)
# Title Authors PMID Year
1
Sjögren-larsson syndrome: a study of clinical symptoms and dermatological treatment in 34 Swedish patients. 9 38
19197545 2009
2
[Clinical consequences of neuromuscular impairments in critically ill patients]. 9 38
16768037 2006
3
[An autopsied case of schizophrenic patient who died from heat stroke]. 9 38
16780054 2006
4
Adeno-associated virus vectors are able to restore fatty aldehyde dehydrogenase-deficiency. Implications for gene therapy in Sjogren-Larsson syndrome. 9 38
15834613 2005
5
Update on Sjögren-Larsson syndrome. 9 38
8884139 1996
6
[Etiological aspects of orthostatic hypotension]. 9 38
1344926 1992
7
Excess burden of a chronic disabling condition: life lost due to traumatic spinal cord injury in a Swiss population-based cohort study. 38
31147730 2019
8
Accuracy of Impedance Cardiography for Hemodynamic Assessment During Rest and Exercise in Wheelchair Rugby Players. 38
31082312 2019
9
A Novel Pharyngeal Clearance Maneuver for Initial Tracheostomy Tube Cuff Deflation in High Cervical Tetraplegia. 38
30973517 2019
10
Long-term prognosis of epilepsy in patients with cerebral palsy. 38
30854645 2019
11
Cross-cultural validation of a Brazilian version of the adapted manual wheelchair circuit (AMWC-Brazil). 38
29659301 2019
12
Treatment considerations for cervical and cervicothoracic spondylodiscitis associated with esophageal fistula due to cancer history or accidental injury: a 9-patient case series. 38
31256278 2019
13
Patient Reported Bladder Related Symptoms and Quality of Life after Spinal Cord Injury with Different Bladder Management Strategies. 38
30958741 2019
14
Poor adherence to influenza vaccination guidelines in spinal cord injury: results from a community-based survey in Switzerland. 38
31371803 2019
15
Influence of training protocols on text input speed on a computer in individuals with cervical spinal cord injury: a randomised controlled trial. 38
30814669 2019
16
Is admission to an SCI specialized rehabilitation facility associated with better functional outcomes? Analysis of data from the Thai Spinal Cord Injury Registry. 38
30842632 2019
17
Scoping review of peer reviewed publications addressing rehabilitation for people sustaining traumatic spinal cord injury. 38
31403376 2019
18
Independent Influence of Spinal Cord Injury Level on Thermoregulation during Exercise. 38
30865188 2019
19
Evaporative heat loss insufficient to attain heat balance at rest in individuals with a spinal cord injury at high ambient temperature. 38
31414956 2019
20
Longitudinal MRI findings in patient with SLC25A12 pathogenic variants inform disease progression and classification. 38
31403263 2019
21
Perioperative acute neurological deficits in instrumented pediatric cervical spine fusions. 38
31419801 2019
22
Continuous Positive Airway Pressure use for Obstructive Sleep Apnea in Acute, Traumatic Tetraplegia. 38
31421094 2019
23
Peer mentoring reduces unplanned readmissions and improves self-efficacy following inpatient rehabilitation for individuals with spinal cord injury. 38
31403374 2019
24
Healthcare-associated urinary tract infections with onset post hospital discharge. 38
31217038 2019
25
Nerve transfers to restore upper limb function in tetraplegia. 38
31280964 2019
26
Motor Point Topography of Fundamental Grip Actuators in Tetraplegia: Implications in Nerve Transfer Surgery. 38
31237477 2019
27
Expanding traditional tendon-based techniques with nerve transfers for the restoration of upper limb function in tetraplegia: a prospective case series. 38
31280969 2019
28
Interrater and intrarater reliability of ventilatory thresholds determined in individuals with spinal cord injury. 38
30820032 2019
29
[Effectiveness of the virtual reality in the rehabilitation of the upper limb in the spinal cord injury. A systematic review]. 38
31334556 2019
30
Respiratory muscle training in athletes with cervical spinal cord injury: effects on cardiopulmonary function and exercise capacity. 38
31115056 2019
31
Quantification of trunk and android lean mass using dual energy x-ray absorptiometry compared to magnetic resonance imaging after spinal cord injury. 38
29461936 2019
32
A randomised controlled trial of nasal decongestant to treat obstructive sleep apnoea in people with cervical spinal cord injury. 38
30760846 2019
33
The Origin of Present-on-admission Pressure Ulcers/Injuries Among Patients Admitted from the Community: Results of a Retrospective Study. 38
31373560 2019
34
Nerve transfers in the upper extremity following cervical spinal cord injury. Part 1: Systematic review of the literature. 38
31299644 2019
35
Comparison between esophageal and intestinal temperature responses to upper-limb exercise in individuals with spinal cord injury. 38
30765840 2019
36
Periostin and sclerostin levels in individuals with spinal cord injury and their relationship with bone mass, bone turnover, fracture and osteoporosis status. 38
31351195 2019
37
Chikungunya-induced inflammatory myositis: a case report in India. 38
31018774 2019
38
Beta-thalassemia major complicated by intracranial hemorrhage and critical illness polyneuropathy. 38
31317877 2019
39
Factors influencing adherence to continuous positive airway pressure devices in individuals with spinal cord injury and sleep apnea: Results of a qualitative study. 38
31302281 2019
40
Locked-In Syndrome Following Cervical Manipulation by a Chiropractor: A Case Report. 38
31431924 2019
41
Cervical anaerobic vertebral osteomyelitis following surgical tracheotomy: a case report. 38
31331282 2019
42
Profile of children with cerebral palsy spectrum disorder and a normal MRI study. 38
31127072 2019
43
Prevalence, Patterns, and Cost of Care for Children with Cerebral Palsy Enrolled in Medicaid Managed Care. 38
31232210 2019
44
Becoming a young adult with cerebral palsy. 38
31330443 2019
45
Mesenchymal stem cell derived EVs mediate neuroprotection after spinal cord injury in rats via the microRNA-21-5p/FasL gene axis. 38
31102912 2019
46
Clinically Significant Gains in Skillful Grasp Coordination by an Individual With Tetraplegia Using an Implanted Brain-Computer Interface With Forearm Transcutaneous Muscle Stimulation. 38
30902630 2019
47
An Unexpected Cause of Transient Tetraplegia. 38
31338706 2019
48
Nerve transfers in the upper extremity following cervical spinal cord injury. Part 2: Preliminary results of a prospective clinical trial. 38
31299645 2019
49
A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent. 38
31009750 2019
50
Associations between insurance provider and assistive technology use for computer and electronic devices one year after tetraplegia: Findings from the Spinal Cord Injury Model Systems National Database. 38
31351077 2019

Variations for Quadriplegia

Expression for Quadriplegia

Search GEO for disease gene expression data for Quadriplegia.

Pathways for Quadriplegia

GO Terms for Quadriplegia

Cellular components related to Quadriplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase complex GO:0005890 9.16 ATP1A3 ATP1A2
2 myelin sheath GO:0043209 8.96 PLP1
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.96 SDHD SDHA
4 extracellular vesicle GO:1903561 8.8 SPTAN1 ATP1A3 ATP1A2

Biological processes related to Quadriplegia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.49 ATP1A3 ATP1A2
2 tricarboxylic acid cycle GO:0006099 9.48 SDHD SDHA
3 ATP hydrolysis coupled proton transport GO:0015991 9.46 ATP1A3 ATP1A2
4 cellular sodium ion homeostasis GO:0006883 9.43 ATP1A3 ATP1A2
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.4 ATP1A3 ATP1A2
6 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.37 ATP1A3 ATP1A2
7 sodium ion export across plasma membrane GO:0036376 9.32 ATP1A3 ATP1A2
8 cellular response to steroid hormone stimulus GO:0071383 9.26 ATP1A3 ATP1A2
9 cellular potassium ion homeostasis GO:0030007 9.16 ATP1A3 ATP1A2
10 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.96 SDHD SDHA
11 response to glycoside GO:1903416 8.62 ATP1A3 ATP1A2

Molecular functions related to Quadriplegia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP1A3 ATP1A2
2 steroid hormone binding GO:1990239 9.16 ATP1A3 ATP1A2
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.96 SDHD SDHA
4 succinate dehydrogenase activity GO:0000104 8.62 SDHD SDHA

Sources for Quadriplegia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....