Quebec Platelet Disorder disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

QPD MCID: QBC001 MIFTS: 41	Quebec Platelet Disorder (QPD) Categories: Blood diseases, Genetic diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Quebec Platelet Disorder

MalaCards integrated aliases for Quebec Platelet Disorder:

Name: Quebec Platelet Disorder ⁵⁷ ¹² ⁷⁶ ⁵³ ⁵⁹ ⁷⁵ ²⁹ ¹³ ⁵⁵ ⁶ ⁴⁴ ¹⁵ ⁷³

Factor V Quebec ⁵⁷ ¹² ⁵³ ⁵⁹ ⁷⁵

Bdplt5 ⁵⁷ ¹² ⁷⁵

Qpd ⁵⁷ ⁵³ ⁷⁵

Bleeding Disorder, Platelet-Type, 5; Bdplt5 ⁵⁷

Bleeding Disorder, Platelet-Type, 5 ⁵⁷

Platelet-Type Bleeding Disorder 5 ¹²

Bleeding Disorder Platelet-Type 5 ⁷⁵

Platelet Disorder, Quebec ⁴⁰

Characteristics:

Orphanet epidemiological data:

⁵⁹

quebec platelet disorder
Inheritance: Autosomal dominant;

OMIM:

⁵⁷

Inheritance:
autosomal dominant

Miscellaneous:
bleeding is usually delayed-onset after challenge
good response to fibrinolytic inhibitors
prevalence of 1 in 300,000 in quebec

HPO:

³²

quebec platelet disorder:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Coagulation defects, purpura and other haemorrhagic conditions

Purpura and other haemorrhagic conditions

Qualitative platelet defects

Orphanet: ⁵⁹

Rare haematological diseases

External Ids:

OMIM ⁵⁷ 601709

Disease Ontology ¹² DOID:0111050

MeSH ⁴⁴ C536260 D006470

Orphanet ⁵⁹ ORPHA220436

MESH via Orphanet ⁴⁵ C536260

UMLS via Orphanet ⁷⁴ C1866423

ICD10 via Orphanet ³⁴ D69.1

MedGen ⁴² C1866423

SNOMED-CT via HPO ⁶⁹ 263681008 386692008 12441001 more

UMLS ⁷³ C1866423

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Summaries for Quebec Platelet Disorder

OMIM : ⁵⁷ Quebec platelet disorder is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins. The disorder shows a favorable therapeutic response to fibrinolytic inhibitors (summary by Diamandis et al., 2009). (601709)

MalaCards based summary : Quebec Platelet Disorder, also known as factor v quebec, is related to factor v deficiency and blood platelet disease. An important gene associated with Quebec Platelet Disorder is PLAU (Plasminogen Activator, Urokinase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). Affiliated tissues include heart, and related phenotypes are thrombocytopenia and epistaxis

Disease Ontology : ¹² An inherited blood coagulation disease characterized by autosomal dominant inheritance of delayed onset bleeding after challenge, moderate to severe bleeding tendencies, frequent ecchymoses, mucocutaneous bleeding, muscle and joint bleeds and platelet alpha-granule degredation that has material basis in heterozygous tandem duplication of the PLAU gene on chromosome 10q22.

NIH Rare Diseases : ⁵³ The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 220436Disease definitionQuebec plateletsyndrome (QPS) is a platelet granule disorder characterized by moderate to severe bleeding after trauma, surgery or obstetric interventions, frequent ecchymoses, mucocutaneous bleeding and muscle and joint bleeds.Visit the Orphanet disease page for more resources.

UniProtKB/Swiss-Prot : ⁷⁵ Quebec platelet disorder: An autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.

Wikipedia : ⁷⁶ Quebec Platelet Disorder (QPD) is a rare, autosomal dominant bleeding disorder described in a family... more...

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Related Diseases for Quebec Platelet Disorder

Diseases related to Quebec Platelet Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)

#	Related Disease	Score	Top Affiliating Genes
1	factor v deficiency	11.5
2	blood platelet disease	10.5
3	buerger disease	10.0	PLAU SERPINE1
4	paranasal sinus disease	9.9	PLAU SERPINE1
5	inferior vena cava interruption	9.9	F5 SERPINE1
6	amaurosis fugax	9.9	F5 SERPINE1
7	sticky platelet syndrome	9.9	F5 SERPINE1
8	cryptogenic cirrhosis	9.9	F5 SERPINE1
9	ischemic colitis	9.9	F5 SERPINE1
10	catastrophic antiphospholipid syndrome	9.9	F5 SERPINE1
11	thrombophlebitis	9.9	F5 SERPINE1
12	meningococcemia	9.9	F5 SERPINE1
13	factor xiii deficiency	9.9	F5 SERPINE1
14	post-thrombotic syndrome	9.9	F5 SERPINE1
15	legg-calve-perthes disease	9.9	F5 SERPINE1
16	retinal artery occlusion	9.9	F5 SERPINE1
17	portal vein thrombosis	9.9	F5 SERPINE1
18	thrombosis	9.9	F5 SERPINE1
19	thrombocytopenia	9.9
20	vein disease	9.9	F5 SERPINE1
21	intracranial hypertension	9.9	F5 SERPINE1
22	retinal vein occlusion	9.9	F5 SERPINE1
23	thrombophilia due to activated protein c resistance	9.9	F5 SERPINE1
24	thrombophilia	9.9	F5 SERPINE1
25	disseminated intravascular coagulation	9.9	F5 SERPINE1
26	thrombophilia due to thrombin defect	9.9	F5 SERPINE1
27	hirschsprung disease 1	9.9	C10orf55 PLAU
28	pulmonary embolism	9.9	F5 SERPINE1
29	hemorrhagic disease	9.8	F5 SERPINE1
30	hellp syndrome	9.8	F5 SERPINE1
31	coronary artery anomaly	9.8	F5 SERPINE1
32	fibrosarcoma	9.8	PLAU SERPINE1
33	cerebrovascular disease	9.8	F5 SERPINE1

Graphical network of the top 20 diseases related to Quebec Platelet Disorder:

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Symptoms & Phenotypes for Quebec Platelet Disorder

Symptoms via clinical synopsis from OMIM:

⁵⁷

Hematology:
normal platelet morphology
moderate-severe bleeding tendencies (epistaxis, menorrhagia, hemarthrosis, easy bruisability)
thrombocytopenia, mild
mildly decreased to low-normal platelet count (80-150 x 10(9)/l)
bleeding time normal to mildly prolonged
more

Clinical features from OMIM:

601709

Human phenotypes related to Quebec Platelet Disorder:

³² (show all 6)

#	Description	HPO Source Accession
1	thrombocytopenia ³²	HP:0001873
2	epistaxis ³²	HP:0000421
3	bruising susceptibility ³²	HP:0000978
4	menorrhagia ³²	HP:0000132
5	joint hemorrhage ³²	HP:0005261
6	impaired epinephrine-induced platelet aggregation ³²	HP:0008148

MGI Mouse Phenotypes related to Quebec Platelet Disorder:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	8.92	F5 PLAU SERPINE1 SPARC

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Drugs & Therapeutics for Quebec Platelet Disorder

Search Clinical Trials , NIH Clinical Center for Quebec Platelet Disorder

Cochrane evidence based reviews: quebec platelet disorder

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Genetic Tests for Quebec Platelet Disorder

Genetic tests related to Quebec Platelet Disorder:

#	Genetic test	Affiliating Genes
1	Quebec Platelet Disorder ²⁹	PLAU

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Anatomical Context for Quebec Platelet Disorder

MalaCards organs/tissues related to Quebec Platelet Disorder:

⁴¹

Heart

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Publications for Quebec Platelet Disorder

Articles related to Quebec Platelet Disorder:

(show all 17)

#	Title	Authors	Year
1	Thrombopoietin levels in Quebec platelet disorder-Implications for the mechanism of thrombocytopenia. ( 29388746 )		2018
2	The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes. ( 28301587 )	Hayward C.P....Wilson M.D.	2017
3	Simultaneous measurement of adenosine triphosphate release and aggregation potentiates human platelet aggregation responses for some subjects, including persons with Quebec platelet disorder. ( 22234747 )		2012
4	Quebec platelet disorder. ( 21495923 )	Hayward C.P....Rivard G.E.	2011
5	Quebec platelet disorder: update on pathogenesis, diagnosis, and treatment. ( 22102275 )	Blavignac J....Hayward C.P.	2011
6	Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene. ( 20007542 )	Paterson A.D....Hayward C.P.	2010
7	Quebec platelet disorder. ( 20688024 )	Abbasi A.H....Hussain S.A.	2010
8	Quebec platelet disorder is linked to the urokinase plasminogen activator gene (PLAU) and increases expression of the linked allele in megakaryocytes. ( 18988861 )	Diamandis M....Hayward C.P.	2009
9	Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation. ( 19029443 )	Veljkovic D.K....Hayward C.P.	2009
10	Evaluation of urokinase plasminogen activator in urine from individuals with Quebec platelet disorder. ( 18600101 )	Diamandis M....Hayward C.P.	2008
11	Quebec platelet disorder: features, pathogenesis and treatment. ( 18277131 )	Diamandis M....Hayward C.P.	2008
12	Insights into abnormal hemostasis in the Quebec platelet disorder from analyses of clot lysis. ( 16689763 )		2006
13	Bleeding risks associated with inheritance of the Quebec platelet disorder. ( 15026313 )	McKay H....Hayward C.P.	2004
14	Intracellular activation of the fibrinolytic cascade in the Quebec Platelet Disorder. ( 12888877 )		2003
15	Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator. ( 11435291 )	Kahr W.H....Hayward C.P.	2001
16	Fibrinogen degradation products in patients with the Quebec platelet disorder. ( 9163623 )	Hayward C.P....Rivard G.E.	1997
17	Studies of a second family with the Quebec platelet disorder: evidence that the degradation of the alpha-granule membrane and its soluble contents are not secondary to a defect in targeting proteins to alpha-granules. ( 9028947 )	Hayward CP...Rivard GE	1997

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Genes for Quebec Platelet Disorder

Genes related to Quebec Platelet Disorder (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1416.93	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative germline mutation ⁵⁹ Genetic Tests ²⁹ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)	19029443 12888877 18600101 (more) 15026313 18988861 11435291
2	C10orf55	Chromosome 10 Open Reading Frame 55	Protein Coding	27.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
3	ADAMTSL1	ADAMTS Like 1	Protein Coding	25.93	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8652809
4	F5	Coagulation Factor V	Protein Coding	23.58	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	8652809 8611679 11421293 (more) 9154319 19408196 9057642
5	SPARC	Secreted Protein Acidic And Cysteine Rich	Protein Coding	21.59	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	SERPINE1	Serpin Family E Member 1	Protein Coding	21.45	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Quebec Platelet Disorder

ClinVar genetic disease variations for Quebec Platelet Disorder:

⁶ (show top 50) (show all 99)

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	PLAU	NC_000010.11: g.73899258_73977195dup	duplication	Pathogenic		GRCh37	Chromosome 10, 75659016: 75736953
2	PLAU	NC_000010.11: g.73899258_73977195dup	duplication	Pathogenic		GRCh38	Chromosome 10, 73899258: 73977195
3	PLAU	NC_000010.11: g.73899258_73977195dup	duplication	Pathogenic		NCBI36	Chromosome 10, 75329022: 75406959
4	PLAU	NM_002658.4(PLAU): c.172G> A (p.Gly58Arg)	single nucleotide variant	Likely benign	rs55744193	GRCh37	Chromosome 10, 75672059: 75672059
5	PLAU	NM_002658.4(PLAU): c.172G> A (p.Gly58Arg)	single nucleotide variant	Likely benign	rs55744193	GRCh38	Chromosome 10, 73912301: 73912301
6	PLAU	NM_002658.4(PLAU): c.-32+9C> G	single nucleotide variant	Likely benign	rs538342269	GRCh37	Chromosome 10, 75670985: 75670985
7	PLAU	NM_002658.4(PLAU): c.-32+9C> G	single nucleotide variant	Likely benign	rs538342269	GRCh38	Chromosome 10, 73911227: 73911227
8	PLAU	NM_002658.4(PLAU): c.-20A> G	single nucleotide variant	Likely benign	rs201591610	GRCh37	Chromosome 10, 75671294: 75671294
9	PLAU	NM_002658.4(PLAU): c.-20A> G	single nucleotide variant	Likely benign	rs201591610	GRCh38	Chromosome 10, 73911536: 73911536
10	PLAU	NM_002658.4(PLAU): c.17C> A (p.Ala6Glu)	single nucleotide variant	Uncertain significance	rs371106595	GRCh37	Chromosome 10, 75671330: 75671330
11	PLAU	NM_002658.4(PLAU): c.17C> A (p.Ala6Glu)	single nucleotide variant	Uncertain significance	rs371106595	GRCh38	Chromosome 10, 73911572: 73911572
12	PLAU	NM_002658.4(PLAU): c.163A> G (p.Lys55Glu)	single nucleotide variant	Uncertain significance	rs147372618	GRCh37	Chromosome 10, 75672050: 75672050
13	PLAU	NM_002658.4(PLAU): c.163A> G (p.Lys55Glu)	single nucleotide variant	Uncertain significance	rs147372618	GRCh38	Chromosome 10, 73912292: 73912292
14	PLAU	NM_002658.4(PLAU): c.308C> T (p.Thr103Met)	single nucleotide variant	Uncertain significance	rs370278611	GRCh38	Chromosome 10, 73913038: 73913038
15	PLAU	NM_002658.4(PLAU): c.308C> T (p.Thr103Met)	single nucleotide variant	Uncertain significance	rs370278611	GRCh37	Chromosome 10, 75672796: 75672796
16	PLAU	NM_002658.4(PLAU): c.368+6G> C	single nucleotide variant	Uncertain significance	rs186447765	GRCh38	Chromosome 10, 73913104: 73913104
17	PLAU	NM_002658.4(PLAU): c.368+6G> C	single nucleotide variant	Uncertain significance	rs186447765	GRCh37	Chromosome 10, 75672862: 75672862
18	PLAU	NM_002658.4(PLAU): c.581C> A (p.Ala194Glu)	single nucleotide variant	Uncertain significance	rs145865648	GRCh38	Chromosome 10, 73913659: 73913659
19	PLAU	NM_002658.4(PLAU): c.581C> A (p.Ala194Glu)	single nucleotide variant	Uncertain significance	rs145865648	GRCh37	Chromosome 10, 75673417: 75673417
20	PLAU	NM_002658.4(PLAU): c.878G> A (p.Arg293Gln)	single nucleotide variant	Likely benign	rs546931331	GRCh38	Chromosome 10, 73914824: 73914824
21	PLAU	NM_002658.4(PLAU): c.878G> A (p.Arg293Gln)	single nucleotide variant	Likely benign	rs546931331	GRCh37	Chromosome 10, 75674582: 75674582
22	PLAU	NM_002658.4(PLAU): c.1092C> T (p.Asp364=)	single nucleotide variant	Likely benign	rs148333167	GRCh38	Chromosome 10, 73915372: 73915372
23	PLAU	NM_002658.4(PLAU): c.1092C> T (p.Asp364=)	single nucleotide variant	Likely benign	rs148333167	GRCh37	Chromosome 10, 75675130: 75675130
24	PLAU	NM_002658.4(PLAU): c.*335G> A	single nucleotide variant	Likely benign	rs185909762	GRCh37	Chromosome 10, 75676658: 75676658
25	PLAU	NM_002658.4(PLAU): c.*335G> A	single nucleotide variant	Likely benign	rs185909762	GRCh38	Chromosome 10, 73916900: 73916900
26	PLAU	NM_002658.4(PLAU): c.*900A> G	single nucleotide variant	Uncertain significance	rs886047213	GRCh37	Chromosome 10, 75677223: 75677223
27	PLAU	NM_002658.4(PLAU): c.*900A> G	single nucleotide variant	Uncertain significance	rs886047213	GRCh38	Chromosome 10, 73917465: 73917465
28	PLAU	NM_002658.4(PLAU): c.43G> T (p.Val15Leu)	single nucleotide variant	Benign	rs2227580	GRCh37	Chromosome 10, 75671356: 75671356
29	PLAU	NM_002658.4(PLAU): c.43G> T (p.Val15Leu)	single nucleotide variant	Benign	rs2227580	GRCh38	Chromosome 10, 73911598: 73911598
30	PLAU	NM_002658.4(PLAU): c.162A> G (p.Pro54=)	single nucleotide variant	Likely benign	rs142059320	GRCh37	Chromosome 10, 75672049: 75672049
31	PLAU	NM_002658.4(PLAU): c.162A> G (p.Pro54=)	single nucleotide variant	Likely benign	rs142059320	GRCh38	Chromosome 10, 73912291: 73912291
32	PLAU	NM_002658.4(PLAU): c.236G> A (p.Arg79Gln)	single nucleotide variant	Likely benign	rs201299522	GRCh38	Chromosome 10, 73912966: 73912966
33	PLAU	NM_002658.4(PLAU): c.236G> A (p.Arg79Gln)	single nucleotide variant	Likely benign	rs201299522	GRCh37	Chromosome 10, 75672724: 75672724
34	PLAU	NM_002658.4(PLAU): c.581C> T (p.Ala194Val)	single nucleotide variant	Likely benign	rs145865648	GRCh38	Chromosome 10, 73913659: 73913659
35	PLAU	NM_002658.4(PLAU): c.581C> T (p.Ala194Val)	single nucleotide variant	Likely benign	rs145865648	GRCh37	Chromosome 10, 75673417: 75673417
36	PLAU	NM_002658.4(PLAU): c.602G> T (p.Arg201Leu)	single nucleotide variant	Likely benign	rs549461157	GRCh38	Chromosome 10, 73913680: 73913680
37	PLAU	NM_002658.4(PLAU): c.602G> T (p.Arg201Leu)	single nucleotide variant	Likely benign	rs549461157	GRCh37	Chromosome 10, 75673438: 75673438
38	PLAU	NM_002658.4(PLAU): c.706A> G (p.Ile236Val)	single nucleotide variant	Likely benign	rs150389556	GRCh38	Chromosome 10, 73914005: 73914005
39	PLAU	NM_002658.4(PLAU): c.706A> G (p.Ile236Val)	single nucleotide variant	Likely benign	rs150389556	GRCh37	Chromosome 10, 75673763: 75673763
40	PLAU	NM_002658.4(PLAU): c.1053C> T (p.Tyr351=)	single nucleotide variant	Likely benign	rs558920700	GRCh38	Chromosome 10, 73915333: 73915333
41	PLAU	NM_002658.4(PLAU): c.1053C> T (p.Tyr351=)	single nucleotide variant	Likely benign	rs558920700	GRCh37	Chromosome 10, 75675091: 75675091
42	PLAU	NM_002658.4(PLAU): c.1222G> A (p.Val408Ile)	single nucleotide variant	Likely benign	rs200165551	GRCh38	Chromosome 10, 73916491: 73916491
43	PLAU	NM_002658.4(PLAU): c.1222G> A (p.Val408Ile)	single nucleotide variant	Likely benign	rs200165551	GRCh37	Chromosome 10, 75676249: 75676249
44	PLAU	NM_002658.4(PLAU): c.*3G> A	single nucleotide variant	Uncertain significance	rs886047208	GRCh38	Chromosome 10, 73916568: 73916568
45	PLAU	NM_002658.4(PLAU): c.*3G> A	single nucleotide variant	Uncertain significance	rs886047208	GRCh37	Chromosome 10, 75676326: 75676326
46	PLAU	NM_002658.4(PLAU): c.*52T> A	single nucleotide variant	Likely benign	rs560674195	GRCh38	Chromosome 10, 73916617: 73916617
47	PLAU	NM_002658.4(PLAU): c.*52T> A	single nucleotide variant	Likely benign	rs560674195	GRCh37	Chromosome 10, 75676375: 75676375
48	PLAU	NM_002658.4(PLAU): c.*176G> T	single nucleotide variant	Uncertain significance	rs886047209	GRCh37	Chromosome 10, 75676499: 75676499
49	PLAU	NM_002658.4(PLAU): c.*176G> T	single nucleotide variant	Uncertain significance	rs886047209	GRCh38	Chromosome 10, 73916741: 73916741
50	PLAU	NM_002658.4(PLAU): c.*355C> T	single nucleotide variant	Likely benign	rs140559980	GRCh37	Chromosome 10, 75676678: 75676678

Copy number variations for Quebec Platelet Disorder from CNVD:

⁷

#	CNVD ID	Chromosom	Start	End	Type	Gene Symbol	CNVD Disease
1	45962	10	75670862	75677259	Mutation	PLAU	Quebec platelet disorder

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Expression for Quebec Platelet Disorder

Search GEO for disease gene expression data for Quebec Platelet Disorder.

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Pathways for Quebec Platelet Disorder

Pathways related to Quebec Platelet Disorder according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	12.75	F5 PLAU SERPINE1 SPARC
2	Formation of Fibrin Clot (Clotting Cascade) ⁶⁶ Show member pathways Blood Clotting Cascade ¹ Blood Coagulation Signaling Pathways ⁶⁵ Common Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Prothrombin Activation Pathway ⁶⁴ Intrinsic Pathway of Fibrin Clot Formation ⁶⁶	11.7	F5 PLAU SERPINE1
3	Complement and coagulation cascades ¹ ³⁷	11.47	F5 PLAU SERPINE1
4	E2F transcription factor network ¹	11.3	PLAU SERPINE1
5	ECM proteoglycans ⁶⁶	11.16	SERPINE1 SPARC
6	Senescence and Autophagy in Cancer ¹	11.16	PLAU SERPINE1 SPARC
7	Cell adhesion_ECM remodeling ²²	10.58	PLAU SERPINE1 SPARC
8	Dissolution of Fibrin Clot ⁶⁶	10.37	PLAU SERPINE1

Sources

GO Terms for Quebec Platelet Disorder

Cellular components related to Quebec Platelet Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.56	F5 PLAU SERPINE1 SPARC
2	extracellular region	GO:0005576	9.55	ADAMTSL1 F5 PLAU SERPINE1 SPARC
3	platelet alpha granule	GO:0031091	8.96	F5 SPARC
4	platelet alpha granule lumen	GO:0031093	8.8	F5 SERPINE1 SPARC

Biological processes related to Quebec Platelet Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hemostasis	GO:0007599	9.16	F5 PLAU
2	fibrinolysis	GO:0042730	8.96	PLAU SERPINE1
3	platelet degranulation	GO:0002576	8.8	F5 SERPINE1 SPARC

Sources

Sources for Quebec Platelet Disorder

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia