MCID: RDL001
MIFTS: 31

Radial Nerve Lesion

Categories: Neuronal diseases

Aliases & Classifications for Radial Nerve Lesion

MalaCards integrated aliases for Radial Nerve Lesion:

Name: Radial Nerve Lesion 12 15 17 71
Lesion of Radial Nerve 12 32
Radial Nerve Lesions 12
Radial Neuropathy 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12170
ICD9CM 34 354.3
SNOMED-CT 67 16644004
ICD10 32 G56.3
UMLS 71 C0154744 C0748226

Summaries for Radial Nerve Lesion

MalaCards based summary : Radial Nerve Lesion, also known as lesion of radial nerve, is related to radial neuropathy and borderline leprosy. An important gene associated with Radial Nerve Lesion is CCDC122 (Coiled-Coil Domain Containing 122), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin, and related phenotypes are hematopoietic system and immune system

Related Diseases for Radial Nerve Lesion

Diseases related to Radial Nerve Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 radial neuropathy 10.3 TOR1B CCDC122
2 borderline leprosy 10.3 TOR1B CCDC122
3 post-transplant lymphoproliferative disease 10.2 SLC11A1 LTA
4 gastrointestinal tularemia 10.2 TLR1 SLC11A1
5 parkinson disease 10 10.2 PRKN LRRK2
6 color agnosia 10.2 PRKN LRRK2
7 epilepsy, familial temporal lobe, 2 10.2 TNFSF15 CNTF
8 postencephalitic parkinson disease 10.2 PRKN LRRK2
9 parkinson disease 21 10.1 PRKN LRRK2
10 ophthalmomyiasis 10.1 PRKN LRRK2
11 chromosome 8q21.11 deletion syndrome 10.1 RIPK2 IL7
12 neuroma 10.1
13 immunoglobulin a deficiency 1 10.1 TNFRSF25 LTA
14 parkinson disease 3, autosomal dominant 10.0 PRKN LRRK2
15 campylobacteriosis 10.0 VDR SLC11A1
16 inflammatory bowel disease 15 10.0 TNFSF15 NOD2
17 rem sleep behavior disorder 10.0 PRKN LRRK2 BCHE
18 parkinson disease 15, autosomal recessive early-onset 10.0 PRKN LRRK2
19 toxic encephalopathy 10.0 PRKN LRRK2 BCHE
20 supranuclear palsy, progressive, 1 10.0 PRKN LRRK2 BCHE
21 ocular toxoplasmosis 9.9 TLR1 NOD2
22 lipomatosis, multiple 9.9
23 pleomorphic lipoma 9.9
24 epicondylitis 9.9
25 brachial plexus lesion 9.9
26 dementia, lewy body 9.9 PRKN LRRK2 BCHE
27 parkinson disease 1, autosomal dominant 9.9 PRKN LRRK2
28 inflammatory bowel disease 19 9.9 TNFSF15 NOD2
29 gaucher's disease 9.9 PRKN MRC1 LRRK2
30 pick disease of brain 9.9 PRKN LRRK2 BCHE
31 indeterminate leprosy 9.9 TOR1B TLR1 SLC11A1 RIPK2 CCDC122
32 brachial plexus neuropathy 9.9
33 vasculitis 9.9
34 anorectal stricture 9.9 TNFSF15 NOD2
35 inflammatory bowel disease 1 9.9 TNFSF15 RIPK2 NOD2
36 inflammatory bowel disease 5 9.8 TNFSF15 NOD2
37 q fever 9.8 TLR1 SLC11A1 NOD2
38 lymphoproliferative syndrome, x-linked, 2 9.8 RIPK2 NOD2
39 primary bacterial infectious disease 9.8 TLR1 SLC11A1 NOD2
40 bacterial infectious disease 9.8 TLR1 SLC11A1 NOD2
41 sarcoidosis 1 9.7 SLC11A1 NOD2 LTA
42 multidrug-resistant tuberculosis 9.7 VDR SLC11A1
43 autoimmune disease of gastrointestinal tract 9.7 TNFSF15 TNFRSF25 NOD2
44 salmonellosis 9.7 VDR SLC11A1 NOD2
45 lymphadenitis 9.7 VDR SLC11A1 NOD2
46 erythema nodosum 9.6 VDR NOD2 LTA
47 disease by infectious agent 9.6 SLC11A1 NOD2 LTA IL7
48 crohn's disease 9.5 TNFSF15 RIPK2 NOD2 LTA LRRK2
49 testicular disease 9.1 TNFSF15 TLR1 SLC11A1 RIPK2 PRKN NOD2
50 mycobacterium tuberculosis 1 9.0 VDR TLR1 SLC11A1 NOD2 MRC1 IL7

Graphical network of the top 20 diseases related to Radial Nerve Lesion:



Diseases related to Radial Nerve Lesion

Symptoms & Phenotypes for Radial Nerve Lesion

MGI Mouse Phenotypes related to Radial Nerve Lesion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.77 CCDC122 CNTF IL7 LRRK2 LTA MRC1
2 immune system MP:0005387 9.4 CNTF IL7 LRRK2 LTA MRC1 NOD2

Drugs & Therapeutics for Radial Nerve Lesion

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Delto-Tricipital Compression Syndrome: A Randomized Treatment Comparison Trial of Dextrose Injection Versus Physical Therapy. Unknown status NCT02331069 Dextrose 5% (D5W)
2 Neuromuscular Ultrasound for Focal Neuropathies Completed NCT01394822
3 Fractures of the Humeral Shaft With Primary Radial Nerve Palsy: Do Injury Mechanism, Fracture Type, or Treatment Influence Nerve Recovery: A Retrospective Study Completed NCT03948542
4 Tendon Transfer Surgery for Irreversible Radial Nerve Palsy, Does it Help When Expert is Available? Retrospective Cohort From Level-1 Trauma Center in a Metropolitan City. Completed NCT03936868

Search NIH Clinical Center for Radial Nerve Lesion

Genetic Tests for Radial Nerve Lesion

Anatomical Context for Radial Nerve Lesion

MalaCards organs/tissues related to Radial Nerve Lesion:

40
Skin

Publications for Radial Nerve Lesion

Articles related to Radial Nerve Lesion:

(show all 23)
# Title Authors PMID Year
1
Comparing iatrogenic radial nerve lesions in humeral shaft fractures treated with helical or straight PHILOS plates: a 10-year retrospective cohort study of 62 cases. 61
32253549 2020
2
Management of Radial Nerve Lesions after Trauma or Iatrogenic Nerve Injury: Autologous Grafts and Neurolysis. 61
33255889 2020
3
Final outcomes of radial nerve palsy associated with humeral shaft fracture and nonunion. 61
30923949 2019
4
Louis-Ferdinand Céline: From First World War Neurological Wound to Mythomania. 61
30336472 2018
5
Is locked compressive intramedullary nailing for adult humerus shaft fractures advantageous? 61
28760123 2017
6
Secondary posterior interosseous nerve lesions associated with humeral fractures. 61
26112268 2016
7
Ultrasound in dual nerve impairment after proximal radial nerve lesion. 61
25992766 2015
8
Radial nerve injury associated with humeral shaft fracture: a retrospective study. 61
26327789 2015
9
[Treatment of old radial head dislocation in children]. 61
25417300 2014
10
Radial nerve lesion after malposition and sedation by continuous target controlled infusion of propofol for extracorporeal shock wave lithotripsy. 61
24180179 2013
11
Primary non-Hodgkin's lymphoma of the radial nerve: case report. 61
20657321 2010
12
[A comparision of the prevalence of radial nerve lesion after fixation of humeral shaft fractures with dynamic compression plate versus intramedullary nailing]. 61
19227933 2008
13
Posterior antebrachial cutaneous nerve conduction studies in normal subjects. 61
15003753 2004
14
Nontraumatic paralysis of the radial nerve with multiple constrictions. 61
12671848 2003
15
[Complex tissue reconstruction of the arm with free vascularized fibular graft with skin island]. 61
10093411 1998
16
[Seidel humerus intramedullary nailing. Clinical results of 100 surgeries]. 61
9157559 1997
17
Results of interfascicular nerve grafting for radial nerve lesions. 61
9393662 1996
18
[Radial nerve lesion of the distal upper arm in patients with "tennis elbow"]. 61
2034306 1991
19
[Problems in severe injuries of the radial nerve]. 61
2636307 1989
20
Isolated radial nerve lesion in the newborn. 61
6310439 1983
21
Radial nerve palsy at the elbow following venipuncture-case report. 61
6268698 1981
22
[Radial nerve lesion caused by lipoma situated in the supinator canal]. 61
12414 1976
23
[Inadequate osteosynthesis of the humerus with iatrogenic radial nerve lesion]. 61
4149817 1972

Variations for Radial Nerve Lesion

Expression for Radial Nerve Lesion

Search GEO for disease gene expression data for Radial Nerve Lesion.

Pathways for Radial Nerve Lesion

GO Terms for Radial Nerve Lesion

Biological processes related to Radial Nerve Lesion according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.11 TNFSF15 TNFRSF25 TLR1 RIPK2 LTA LRRK2
2 regulation of apoptotic process GO:0042981 9.88 TNFRSF25 RIPK2 PRKN NOD2
3 positive regulation of gene expression GO:0010628 9.85 VDR SLC11A1 PRKN IL7 CNTF
4 immune response GO:0006955 9.83 TNFSF15 TLR1 SLC11A1 LTA IL7
5 activation of MAPK activity GO:0000187 9.81 RIPK2 NOD2 LRRK2
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 TNFSF15 TNFRSF25 LTA
7 defense response to Gram-positive bacterium GO:0050830 9.79 RIPK2 NOD2 LTA
8 positive regulation of interleukin-6 production GO:0032755 9.77 TLR1 RIPK2 NOD2
9 positive regulation of tumor necrosis factor production GO:0032760 9.76 TLR1 RIPK2 NOD2
10 response to nutrient GO:0007584 9.73 NOD2 LTA BCHE
11 positive regulation of protein ubiquitination GO:0031398 9.7 RIPK2 NOD2 LRRK2
12 nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 9.65 RIPK2 NOD2
13 positive regulation of protein binding GO:0032092 9.65 RIPK2 PRKN LRRK2
14 positive regulation of stress-activated MAPK cascade GO:0032874 9.64 RIPK2 NOD2
15 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.64 PRKN LRRK2
16 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.62 NOD2 LRRK2
17 cellular response to dopamine GO:1903351 9.62 PRKN LRRK2
18 macrophage activation GO:0042116 9.61 TLR1 SLC11A1
19 positive regulation of T-helper 1 type immune response GO:0002827 9.59 SLC11A1 RIPK2
20 positive regulation of interferon-gamma production GO:0032729 9.58 SLC11A1 RIPK2 LTA
21 positive regulation of cytokine-mediated signaling pathway GO:0001961 9.57 RIPK2 IL7
22 cellular response to manganese ion GO:0071287 9.55 PRKN LRRK2
23 cellular response to muramyl dipeptide GO:0071225 9.54 RIPK2 NOD2
24 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070431 9.49 RIPK2 NOD2
25 positive regulation of xenophagy GO:1904417 9.37 RIPK2 NOD2
26 protein localization to mitochondrion GO:0070585 9.32 PRKN LRRK2
27 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.26 SLC11A1 NOD2
28 cellular response to peptidoglycan GO:0071224 9.16 RIPK2 NOD2
29 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 8.96 NOD2 LTA
30 regulation of synaptic vesicle transport GO:1902803 8.62 PRKN LRRK2

Molecular functions related to Radial Nerve Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CARD domain binding GO:0050700 8.96 RIPK2 NOD2
2 cytokine activity GO:0005125 8.92 TNFSF15 LTA IL7 CNTF

Sources for Radial Nerve Lesion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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