MCID: RDT001
MIFTS: 31

Radiation Cystitis

Categories: Nephrological diseases

Aliases & Classifications for Radiation Cystitis

MalaCards integrated aliases for Radiation Cystitis:

Name: Radiation Cystitis 12 15
Irradiation Cystitis 12 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:7127
ICD9CM 34 595.82
NCIt 50 C123174
SNOMED-CT 67 11251000
ICD10 32 N30.4
UMLS 70 C0156270

Summaries for Radiation Cystitis

MalaCards based summary : Radiation Cystitis, also known as irradiation cystitis, is related to interstitial cystitis and chronic cystitis. An important gene associated with Radiation Cystitis is KLK3 (Kallikrein Related Peptidase 3). The drugs Aspirin and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include prostate, cervix and colon.

Related Diseases for Radiation Cystitis

Diseases related to Radiation Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 interstitial cystitis 30.1 UPK3A P2RX3
2 chronic cystitis 29.8 UPK3A P2RX3
3 acute cystitis 29.7 UPK3A KLK3
4 neurogenic bladder 29.4 UPK3A P2RX3 P2RX1 KLK3
5 cystitis 10.9
6 hemorrhagic cystitis 10.3
7 prostate cancer 10.2
8 urethra cancer 10.2 UPK3A KLK3
9 urethral diverticulum 10.2 UPK3A KLK3
10 pyuria 10.1 UPK3A KLK3
11 proctitis 10.1
12 urethra clear cell adenocarcinoma 10.1 UPK3A KLK3
13 bladder adenocarcinoma 10.1 UPK3A KLK3
14 bladder sarcoma 10.1 UPK3A KLK3
15 bladder cancer 10.1
16 telangiectasis 10.1
17 radiation proctitis 10.1
18 prostatic acinar adenocarcinoma 10.1 SLC45A3 KLK3
19 urethral syndrome 10.0 P2RX3 KLK3
20 urinary tract infection 10.0
21 villous adenoma 10.0 SLC45A3 KLK3
22 bartholin's gland adenocarcinoma 10.0 UPK3A SLC45A3
23 urinary tract obstruction 9.8 UPK3A KLK3
24 fibrosis of extraocular muscles, congenital, 1 9.8
25 suppressor of tumorigenicity 3 9.8
26 vesicoureteral reflux 1 9.8
27 suppression of tumorigenicity 12 9.8
28 cervical cancer 9.8
29 endometrial cancer 9.8
30 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.8
31 metabolic acidosis 9.8
32 colitis 9.8
33 low compliance bladder 9.8
34 acute kidney tubular necrosis 9.8
35 bacteriuria 9.8
36 impotence 9.8
37 intestinal perforation 9.8
38 transitional cell carcinoma 9.8
39 bladder urothelial carcinoma 9.8
40 peptic ulcer disease 9.8
41 peritonitis 9.8
42 posttransplant acute limbic encephalitis 9.8
43 urachal diverticulum 9.8
44 thyroid carcinoma 9.8

Comorbidity relations with Radiation Cystitis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Bladder Cancer Bladder Neck Obstruction
Cystitis Deficiency Anemia
Hydronephrosis Intestinal Obstruction
Prostate Cancer Urethral Stricture

Graphical network of the top 20 diseases related to Radiation Cystitis:



Diseases related to Radiation Cystitis

Symptoms & Phenotypes for Radiation Cystitis

Drugs & Therapeutics for Radiation Cystitis

Drugs for Radiation Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved 50-78-2 2244
2 Anesthetics
3 Anticoagulants
4 Tin Fluorides

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of the Effects of Anticoagulant Interruption Covered by Percutaneous Left Atrial Occlusion in Patients With Chronic Atrial Fibrillation and Radiation Cystitis at Risk of Bleeding Not yet recruiting NCT04701749

Search NIH Clinical Center for Radiation Cystitis

Genetic Tests for Radiation Cystitis

Anatomical Context for Radiation Cystitis

MalaCards organs/tissues related to Radiation Cystitis:

40
Prostate, Cervix, Colon, Uterus, Thyroid, Skin

Publications for Radiation Cystitis

Articles related to Radiation Cystitis:

(show top 50) (show all 321)
# Title Authors PMID Year
1
[Hyperbaric oxygen therapy efficacy in the treatment of hematuria due to radiation cystitis. Experience in a reference center.] 61
33650536 2021
2
Effect of irradiation on the expression of E-cadherin and β-catenin in early and late radiation sequelae of the urinary bladder and its modulation by NF-κB inhibitor thalidomide. 61
33688971 2021
3
Complications and side effects of high-dose-rate prostate brachytherapy. 61
33612395 2021
4
BladderScan Feedback Method in Predicting Bladder Filling for Prostate Radiotherapy: A Prospective Study. 61
33706617 2021
5
Lower Urinary Tract Symptoms in Prostate Cancer Patients Treated With Radiation Therapy: Past and Present. 61
33504132 2021
6
The scope, presentation, and management of genitourinary complications in patients presenting with high-grade urethral complications after radiotherapy for prostate cancer. 61
32701436 2021
7
The clinical research of 5 steps sequential method for whole treatment of hemorrhagic radiation cystitis in china. 61
33437210 2021
8
A case of pubic abscess after prostate cancer surgery and radiotherapy treated with rectus femoris muscle flap. 61
33134471 2020
9
First Reported Case of Hyperchloremic Non-Anion Gap Metabolic Acidosis in a Patient Undergoing Continuous Bladder Irrigation for Hemorrhagic Cystitis. 61
33489544 2020
10
Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives. 61
33374374 2020
11
A comparison of two hyperbaric oxygen regimens: 2.0 ATA for 120 minutes to 2.4 ATA for 90 minutes in treating radiation-induced cystitis Are these regimens equivalent? 61
33227834 2020
12
A non-invasive ultrasound imaging method to measure acute radiation-induced bladder wall thickening in rats. 61
33069240 2020
13
Applications of electromotive drug administration in urology. 61
33776323 2020
14
Hyperbaric oxygen for radiation-induced cystitis: A long-term follow-up. 61
32736899 2020
15
Role of Hyperbaric Medicine for Osteoradionecrosis and Post Irradiation Wounds: an Institutional Experience. 61
33013130 2020
16
Urologic Complications Requiring Intervention Following High-dose Pelvic Radiation for Cervical Cancer. 61
32961221 2020
17
An observational trial to establish the effect of hyperbaric oxygen treatment on pelvic late radiation tissue injury due to radiotherapy. 61
32957127 2020
18
Re: Current Management of Radiation Cystitis: A Review and Practical Guide to Clinical Management. 61
32401585 2020
19
Re: Photoselective Vaporization of the Bladder for the Management of Radiation Cystitis-Technique and Initial Outcomes. 61
32401586 2020
20
Cranberry capsules are not superior to placebo capsules in managing acute non-haemorrhagic radiation cystitis in prostate cancer patients: A phase III double blinded randomised placebo controlled clinical trial. 61
32413530 2020
21
Costing Urologic Complications Following Pelvic Radiation Therapy. 61
32194089 2020
22
Translational Aspects of Nuclear Factor-Kappa B and Its Modulation by Thalidomide on Early and Late Radiation Sequelae in Urinary Bladder Dysfunction. 61
32035188 2020
23
Safety analysis of long-term phenazopyridine use for radiation cystitis. 61
31006341 2020
24
Hyperbaric oxygen therapy for radiation cystitis after pelvic radiotherapy: Systematic review of the recent literature. 61
31617263 2020
25
Radiation cystitis modeling: A comparative study of bladder fibrosis radio-sensitivity in C57BL/6, C3H, and BALB/c mice. 61
32109348 2020
26
A study protocol of vaginal laser therapy in gynecological cancer survivors. 61
31474161 2020
27
Prostate cancer survivors with symptoms of radiation cystitis have elevated fibrotic and vascular proteins in urine. 61
33119677 2020
28
Concurrent urinary and bowel diversion: Surgical modification with sigmoid colon that avoids a bowel anastomosis. 61
31851467 2020
29
Erratum for PMID: 31689017. 61
32176961 2020
30
Pre-clinical Research on Bladder Toxicity After Radiotherapy for Pelvic Cancers: State-of-the Art and Challenges. 61
33194587 2020
31
A Prospective Single-Arm Phase 2 Study of Stereotactic Magnetic Resonance Guided Adaptive Radiation Therapy for Prostate Cancer: Early Toxicity Results. 61
31419510 2019
32
Evolution in technique of robotic intracorporeal continent catheterizable pouch after cystectomy. 61
31893282 2019
33
Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): a randomised, controlled, phase 2-3 trial. 61
31537473 2019
34
Hyperbaric oxygen for radiation cystitis. 61
31537474 2019
35
Current management of radiation cystitis: a review and practical guide to clinical management. 61
30113758 2019
36
Editorial Comment on: Endoscopic Intravesical Fibrin Glue Application in the Treatment of Refractory Hemorrhagic Radiation Cystitis: A Single Cohort Pilot Study by Bove et al. (From: Bove P, Iacovelli V, Tirindelli MC, et al. J Endourol 2019;33:93-98; DOI: 10.1089/end.2018.0028). 61
30632409 2019
37
Endoscopic Intravesical Fibrin Glue Application in the Treatment of Refractory Hemorrhagic Radiation Cystitis: A Single Cohort Pilot Study. 61
30280911 2019
38
HBO2 for radiation cystitis 61
31689017 2019
39
Urinary infection or radiation cystitis? A prospective evaluation of urinary symptoms in patients submitted to pelvic radiotherapy. 61
31778433 2019
40
Photoselective Vaporization of the Bladder for the Management of Radiation Cystitis-Technique and Initial Outcomes. 61
29777786 2019
41
Urologic Complications Following Pelvic Radiotherapy. 61
30036617 2018
42
Risk of continuous bladder irrigation in the monoplace hyperbaric chamber: a cautionary tale. 61
31158936 2018
43
Relaxin-2 therapy reverses radiation-induced fibrosis and restores bladder function in mice. 61
29806709 2018
44
Altered Angiogenic Growth Factors in Urine of Prostate Cancer Survivors With Radiation History and Radiation Cystitis. 61
30059715 2018
45
Cancer survivorship issues with radiation and hemorrhagic cystitis in gynecological malignancies. 61
30132277 2018
46
Elevated Urine Levels of Macrophage Migration Inhibitory Factor in Inflammatory Bladder Conditions: A Potential Biomarker for a Subgroup of Interstitial Cystitis/Bladder Pain Syndrome Patients. 61
29580781 2018
47
Changes in the Neuronal Control of the Urinary Bladder in a Model of Radiation Cystitis. 61
29530925 2018
48
[Management of urinary bladder radiation injury]. 61
29901288 2018
49
Cumulative incidence and predictive factors of radiation cystitis in patients with localized prostate cancer. 61
29169704 2018
50
Unmasking of Urinary-pubic Symphysis Fistula After Implantation of Artificial Urinary Sphincter in Prostate Cancer Survivors-User Beware. 61
29277656 2018

Variations for Radiation Cystitis

Expression for Radiation Cystitis

Search GEO for disease gene expression data for Radiation Cystitis.

Pathways for Radiation Cystitis

GO Terms for Radiation Cystitis

Cellular components related to Radiation Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of nuclear inner membrane GO:0005639 8.62 P2RX3 P2RX1

Biological processes related to Radiation Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.43 P2RX3 P2RX1 F7
2 cation transmembrane transport GO:0098655 9.4 P2RX3 P2RX1
3 excitatory postsynaptic potential GO:0060079 9.37 P2RX3 P2RX1
4 sensory perception of taste GO:0050909 9.32 TAS2R1 P2RX3
5 neuronal action potential GO:0019228 9.16 P2RX3 P2RX1
6 response to ATP GO:0033198 8.96 P2RX3 P2RX1
7 purinergic nucleotide receptor signaling pathway GO:0035590 8.62 P2RX3 P2RX1

Molecular functions related to Radiation Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellularly ATP-gated cation channel activity GO:0004931 8.96 P2RX3 P2RX1
2 purinergic nucleotide receptor activity GO:0001614 8.62 P2RX3 P2RX1

Sources for Radiation Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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