MCID: RDT001
MIFTS: 32

Radiation Cystitis

Categories: Nephrological diseases
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Aliases & Classifications for Radiation Cystitis

MalaCards integrated aliases for Radiation Cystitis:

Name: Radiation Cystitis 11 14
Irradiation Cystitis 11 71 31

Classifications:



External Ids:

Disease Ontology 11 DOID:7127
ICD9CM 34 595.82
NCIt 49 C123174
SNOMED-CT 68 11251000
ICD10 31 N30.4
UMLS 71 C0156270

Summaries for Radiation Cystitis

MalaCards based summary: Radiation Cystitis, also known as irradiation cystitis, is related to cystitis and interstitial cystitis. An important gene associated with Radiation Cystitis is UPK3A (Uroplakin 3A), and among its related pathways/superpathways are Signal Transduction and G alpha (s) signalling events. The drugs Anticoagulants and Pentosan Sulfuric Polyester have been mentioned in the context of this disorder. Affiliated tissues include prostate, cervix and uterus, and related phenotype is Decreased viability with cisplatin.

Related Diseases for Radiation Cystitis

Diseases related to Radiation Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 cystitis 31.0 VEGFA UPK3A NGF
2 interstitial cystitis 30.3 UPK3A NGF
3 proctitis 30.1 VEGFA KLK3
4 chronic cystitis 29.9 UPK3A NGF
5 acute cystitis 29.9 UPK3A NGF
6 urinary tract infection 29.8 UPK3A KLK3
7 neurogenic bladder 29.7 UPK3A NGF KLK3
8 transitional cell carcinoma 29.5 VEGFA UPK3A KLK3
9 impotence 29.4 VEGFA NGF KLK3
10 hemorrhagic cystitis 10.3
11 prostate cancer 10.2
12 urethra cancer 10.2 UPK3A KLK3
13 nephrogenic adenoma 10.2 UPK3A KLK3
14 urethral diverticulum 10.2 UPK3A KLK3
15 tuberculous epididymitis 10.2 UPK3A KLK3
16 bladder cancer 10.2
17 bladder adenocarcinoma 10.2 UPK3A KLK3
18 pyuria 10.2 UPK3A KLK3
19 urethral stricture 10.2 UPK3A KLK3
20 cervical adenoid basal carcinoma 10.2 MAPK8IP1 KLK3
21 lymphocele 10.1 MAPK8IP1 KLK3
22 cervical cancer 10.1
23 prostate cancer, hereditary, 8 10.1
24 prostate cancer, hereditary, 6 10.1
25 telangiectasis 10.1
26 radiation proctitis 10.1
27 sigmoid disease 10.0 MAPK8IP1 ELAVL3
28 low compliance bladder 10.0 NGF MAPK8IP1
29 urethral syndrome 10.0 UPK3A NGF KLK3
30 papillary transitional carcinoma 9.9 UPK3A CNTN2
31 non-invasive bladder papillary urothelial neoplasm 9.9 UPK3A CNTN2
32 punctate epithelial keratoconjunctivitis 9.9 VEGFA NGF
33 hydronephrosis 9.9 VEGFA UPK3A KLK3
34 rectal disease 9.9 VEGFA KLK3
35 keratopathy 9.9 VEGFA NGF
36 vaginitis 9.9
37 diabetic polyneuropathy 9.9 VEGFA NGF
38 placenta accreta 9.8 VEGFA RXFP1
39 spastic paraplegia 3, autosomal dominant 9.8
40 suppressor of tumorigenicity 3 9.8
41 hypoascorbemia 9.8
42 paine syndrome 9.8
43 suppression of tumorigenicity 12 9.8
44 spastic paraplegia, ataxia, and mental retardation 9.8
45 endometrial cancer 9.8
46 tatton-brown-rahman syndrome 9.8
47 metabolic acidosis 9.8
48 colitis 9.8
49 overactive bladder syndrome 9.8
50 acute kidney tubular necrosis 9.8

Comorbidity relations with Radiation Cystitis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Bladder Cancer Bladder Neck Obstruction
Cystitis Deficiency Anemia
Hydronephrosis Intestinal Obstruction
Prostate Cancer Urethral Stricture

Graphical network of the top 20 diseases related to Radiation Cystitis:



Diseases related to Radiation Cystitis

Symptoms & Phenotypes for Radiation Cystitis

GenomeRNAi Phenotypes related to Radiation Cystitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with cisplatin GR00101-A-4 8.62 ELAVL3 RXFP2

Drugs & Therapeutics for Radiation Cystitis

Drugs for Radiation Cystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anticoagulants Phase 2, Phase 3
2 Pentosan Sulfuric Polyester Phase 2, Phase 3
3
Acetylsalicylic acid Approved, Vet_approved 50-78-2 2244
4 Anesthetics
5 Tin Fluorides

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Controlled, Phase II/III Trial to Evaluate the Efficacy and Safety of U101 Oral Capsules in Radiation-induced Cystitis Recruiting NCT05245591 Phase 2, Phase 3 Pentosan Polysulfate Sodium 100 MG Oral Capsule;Placebo
2 Study of the Effects of Anticoagulant Interruption Covered by Percutaneous Left Atrial Occlusion in Patients With Chronic Atrial Fibrillation and Radiation Cystitis at Risk of Bleeding Recruiting NCT04701749
3 Study of Serum and Urinary Biomarkers and Radiation Cystitis in Patients Treated With Radiotherapy for Localized Prostate Cancer Recruiting NCT05246774

Search NIH Clinical Center for Radiation Cystitis

Genetic Tests for Radiation Cystitis

Anatomical Context for Radiation Cystitis

Organs/tissues related to Radiation Cystitis:

MalaCards : Prostate, Cervix, Uterus, Colon, Thyroid, Skin, Breast

Publications for Radiation Cystitis

Articles related to Radiation Cystitis:

(show top 50) (show all 352)
# Title Authors PMID Year
1
Investigation of the physiological response of radiation-induced cystitis patients using hyperbaric oxygen. 62
36407487 2023
2
Heterogeneity in the pharmacological management of radiation-induced hemorrhagic cystitis. 62
36229357 2022
3
The role of hyperbaric oxygen therapy in the treatment of radiation lesions. 62
35976581 2022
4
Intravesical IR-780 instillation prevents radiation cystitis by protecting urothelial integrity. 62
36208109 2022
5
Emergency department visits for radiation cystitis among patients with a prostate cancer history. 62
34806813 2022
6
Treatment Outcomes of Computer Tomography-Guided Brachytherapy in Cervical Cancer in Hong Kong: A Retrospective Review. 62
36010927 2022
7
Molecular Mechanisms and Key Processes in Interstitial, Hemorrhagic and Radiation Cystitis. 62
36101353 2022
8
Current management of radiation cystitis after pelvic radiotherapy: a systematic review. 62
34714035 2022
9
Two New Potential Therapeutic Approaches in Radiation Cystitis Derived from Mesenchymal Stem Cells: Extracellular Vesicles and Conditioned Medium. 62
36101361 2022
10
Pelvic Irradiation: A Rare Cause of Concomitant Radiation Cystitis and Uretero-Iliac Artery Fistula Causing Gross Hematuria and Hemorrhagic Shock. 62
35812545 2022
11
Efficacy, tolerance and predictors of response to the treatment with hyperbaric oxygen therapy for patients with hemorrhagic radiation cystitis. 62
35818916 2022
12
Increased extracellular matrix stiffness accompanies compromised bladder function in a murine model of radiation cystitis. 62
35301146 2022
13
Two cases of Bacillus Calmette-Guérin cystitis treated with hyperbaric oxygen. 62
35580486 2022
14
[Intravesical instillations for inflammatory and sensory chronic bladder diseases: Literature review and guide to clinical practice]. 62
35125316 2022
15
Cumulative Incidence and Clinical Risk Factors of Radiation Cystitis after Radiotherapy for Prostate Cancer. 62
35290980 2022
16
Understanding Molecular Mechanisms and Identifying Key Processes in Chronic Radiation Cystitis. 62
35163758 2022
17
Study on Appropriate Rectal Volume for External Irradiation in Patients With Cervical Cancer. 62
35273913 2022
18
Evaluation of Implementation Effect of Cervical Cancer Comprehensive Treatment Patients With Whole-Course High-Quality Care Combined With Network Continuation Care. 62
35174206 2022
19
Definitive surgical therapy for refractory radiation cystitis: Evaluating effectiveness, tolerability, and extent of surgical approach. 62
34247908 2021
20
Bladder mucosa-associated lymphoid tissue lymphoma progressed from chronic cystitis along with a comparative genetic analysis during long-term follow-up: a case report. 62
34804832 2021
21
Robot-assisted Cystectomy with Intracorporeal Urinary Diversion After Pelvic Irradiation for Prostate Cancer: Technique and Results from a Single High-volume Center. 62
33838960 2021
22
Complications and side effects of high-dose-rate prostate brachytherapy. 62
33612395 2021
23
Voiding defects in acute radiation cystitis driven by urothelial barrier defect through loss of E-cadherin, ZO-1 and Uroplakin III. 62
34588475 2021
24
Late Changes in the Extracellular Matrix of the Bladder after Radiation Therapy for Pelvic Tumors. 62
34573958 2021
25
The impact of orthotopic reconstruction on female sexuality and quality of life after radical cystectomy for non-malignant bladder conditions. 62
34839630 2021
26
[Analysis of Bladder Tamponade at a Regional Hospital]. 62
34472316 2021
27
Efficacy of helical tomotherapy combined with CT-guided three-dimensional intracavitary brachytherapy in treatment of locally advanced cervical cancer. 62
34564984 2021
28
Effect of irradiation on the expression of E-cadherin and β-catenin in early and late radiation sequelae of the urinary bladder and its modulation by NF-κB inhibitor thalidomide. 62
33688971 2021
29
[Overactive bladder: urodynamic characteristics of detrusor overactivity due to the etiology of low urinary tract dysfun- ction]. 62
34251099 2021
30
Urologic Complications Requiring Intervention Following High-dose Pelvic Radiation for Cervical Cancer. 62
32961221 2021
31
Radiation cystitis: A late effect of radiotherapy in a patient with cervical rhabdomyosarcoma. 62
34121713 2021
32
[Hyperbaric oxygen therapy efficacy in the treatment of hematuria due to radiation cystitis. Experience in a reference center.] 62
33650536 2021
33
The scope, presentation, and management of genitourinary complications in patients presenting with high-grade urethral complications after radiotherapy for prostate cancer. 62
32701436 2021
34
A Comparison of Different Schemes of Neoadjuvant Chemotherapy Followed by Concurrent Chemotherapy and Radiotherapy for Locally Advanced Cervical Cancer: A Retrospective Study. 62
34764693 2021
35
The clinical research of 5 steps sequential method for whole treatment of hemorrhagic radiation cystitis in china. 62
33437210 2021
36
The Intraoperative Use of a Portable Cone-Beam Computed Tomography System for the Diagnosis of Intraperitoneal Bladder Perforation. 62
34603812 2021
37
BladderScan Feedback Method in Predicting Bladder Filling for Prostate Radiotherapy: A Prospective Study. 62
33706617 2021
38
Efficacy and safety of Prostate stereotactic body radiotherapy for metastatic castration-resistant prostate cancer: A prospective cohort study. 62
33848805 2021
39
A case of pubic abscess after prostate cancer surgery and radiotherapy treated with rectus femoris muscle flap. 62
33134471 2020
40
First Reported Case of Hyperchloremic Non-Anion Gap Metabolic Acidosis in a Patient Undergoing Continuous Bladder Irrigation for Hemorrhagic Cystitis. 62
33489544 2020
41
Chronic Inflammation and Radiation-Induced Cystitis: Molecular Background and Therapeutic Perspectives. 62
33374374 2020
42
A comparison of two hyperbaric oxygen regimens: 2.0 ATA for 120 minutes to 2.4 ATA for 90 minutes in treating radiation-induced cystitis Are these regimens equivalent? 62
33227834 2020
43
Applications of electromotive drug administration in urology. 62
33776323 2020
44
Hyperbaric oxygen for radiation-induced cystitis: A long-term follow-up. 62
32736899 2020
45
A non-invasive ultrasound imaging method to measure acute radiation-induced bladder wall thickening in rats. 62
33069240 2020
46
An observational trial to establish the effect of hyperbaric oxygen treatment on pelvic late radiation tissue injury due to radiotherapy. 62
32957127 2020
47
Role of Hyperbaric Medicine for Osteoradionecrosis and Post Irradiation Wounds: an Institutional Experience. 62
33013130 2020
48
Re: Current Management of Radiation Cystitis: A Review and Practical Guide to Clinical Management. 62
32401585 2020
49
Re: Photoselective Vaporization of the Bladder for the Management of Radiation Cystitis-Technique and Initial Outcomes. 62
32401586 2020
50
Cranberry capsules are not superior to placebo capsules in managing acute non-haemorrhagic radiation cystitis in prostate cancer patients: A phase III double blinded randomised placebo controlled clinical trial. 62
32413530 2020

Variations for Radiation Cystitis

Expression for Radiation Cystitis

Search GEO for disease gene expression data for Radiation Cystitis.

Pathways for Radiation Cystitis

Pathways related to Radiation Cystitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.91 VEGFA RXFP3 RXFP2 RXFP1 RLN2 NGF
2
Show member pathways
11.54 RXFP2 RXFP1 RLN2
3 11.05 VEGFA NGF
4 10.86 VEGFA UPK3A
5 9.83 RXFP3 RXFP2 RXFP1 RLN2

GO Terms for Radiation Cystitis

Biological processes related to Radiation Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of adenylate cyclase activity GO:0007190 8.92 RXFP2 RXFP1

Molecular functions related to Radiation Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled peptide receptor activity GO:0008528 9.1 RXFP3 RXFP2 RXFP1

Sources for Radiation Cystitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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