MCID: RDT001
MIFTS: 31

Radiation Cystitis

Categories: Nephrological diseases

Aliases & Classifications for Radiation Cystitis

MalaCards integrated aliases for Radiation Cystitis:

Name: Radiation Cystitis 12 15
Irradiation Cystitis 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7127
ICD10 33 N30.4
ICD9CM 35 595.82
NCIt 50 C123174
SNOMED-CT 68 11251000
UMLS 73 C0156270

Summaries for Radiation Cystitis

MalaCards based summary : Radiation Cystitis, also known as irradiation cystitis, is related to urethra adenocarcinoma and urethra clear cell adenocarcinoma. An important gene associated with Radiation Cystitis is UPK3A (Uroplakin 3A). Affiliated tissues include prostate, cervix and uterus, and related phenotypes are Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation and cellular

Related Diseases for Radiation Cystitis

Diseases related to Radiation Cystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 urethra adenocarcinoma 10.7 KLK3 UPK3A
2 urethra clear cell adenocarcinoma 10.7 KLK3 UPK3A
3 lymphocele 10.7 KLK3 MAPK8IP1
4 urethral benign neoplasm 10.7 KLK3 UPK3A
5 cystitis 10.6
6 urethral diverticulum 10.5 KLK3 UPK3A
7 arthus reaction 10.4 HMOX1 MIF
8 pulmonary hemosiderosis 10.4 F7 MIF
9 sexual disorder 10.3 KLK3 NOS1
10 paraphimosis 10.3 KANTR KLK3
11 substernal goiter 10.3 F7 KANTR
12 anterior cranial fossa meningioma 10.3 F7 KANTR
13 rectal disease 10.3 KANTR KLK3
14 hemometra 10.2 KANTR MAPK8IP1
15 visual agnosia 10.2 F7 KANTR
16 exposure keratitis 10.1 IL13 KANTR
17 enterobiasis 10.1 IL13 XIAP
18 bladder disease 10.0 KLK3 NME1-NME2 UPK3A
19 prostate cancer 10.0
20 prostatitis 10.0
21 proctitis 9.9
22 cervicitis 9.8
23 renovascular hypertension 9.8 HMOX1 NOS1
24 esophageal disease 9.8 IL13 KANTR
25 bladder cancer 9.7
26 suppressor of tumorigenicity 3 9.7
27 vesicoureteral reflux 1 9.7
28 cervical cancer 9.7
29 colitis 9.7
30 neurogenic bladder 9.7
31 interstitial cystitis 9.7
32 thyroiditis 9.7
33 peptic ulcer disease 9.7
34 neuronitis 9.7
35 urachal diverticulum 9.7
36 radiation proctitis 9.7

Comorbidity relations with Radiation Cystitis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Bladder Cancer Bladder Neck Obstruction
Cystitis Deficiency Anemia
Hydronephrosis Intestinal Obstruction
Prostate Cancer Urethral Stricture

Graphical network of the top 20 diseases related to Radiation Cystitis:



Diseases related to Radiation Cystitis

Symptoms & Phenotypes for Radiation Cystitis

GenomeRNAi Phenotypes related to Radiation Cystitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability after Chlamydia trachomatis serovar L2 infection and TNF-alpha/CHX stimulation GR00206-A 8.62 NOS1 XIAP

MGI Mouse Phenotypes related to Radiation Cystitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 XIAP CACNA1C GATM HMOX1 IL13 MAPK8IP1
2 homeostasis/metabolism MP:0005376 9.93 CACNA1C ELAVL3 F7 GATM HMOX1 IL13
3 endocrine/exocrine gland MP:0005379 9.86 CACNA1C GATM HMOX1 IL13 MAPK8IP1 NOS1
4 muscle MP:0005369 9.5 CACNA1C GATM HMOX1 IL13 NOS1 TCAP
5 reproductive system MP:0005389 9.23 CACNA1C GATM HMOX1 IL13 MAPK8IP1 NOS1

Drugs & Therapeutics for Radiation Cystitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Induced Cystitis Treated With Hyperbaric Oxygen - A Randomized Controlled Trial Recruiting NCT01659723 Phase 2, Phase 3 Hyperbaric Oxygen
2 Hyperbaric Oxygen Therapy for Inflammatory Conditions of the Urinary Bladder Recruiting NCT03143920 Early Phase 1
3 Hyperbaric Oxygenation Treatment and Quality of Life Not yet recruiting NCT03570229

Search NIH Clinical Center for Radiation Cystitis

Genetic Tests for Radiation Cystitis

Anatomical Context for Radiation Cystitis

MalaCards organs/tissues related to Radiation Cystitis:

41
Prostate, Cervix, Uterus, Thyroid

Publications for Radiation Cystitis

Articles related to Radiation Cystitis:

(show top 50) (show all 68)
# Title Authors Year
1
Photoselective Vaporisation of the Bladder for the Management of Radiation Cystitis - Technique and Initial Outcomes. ( 29777786 )
2018
2
Protein and micronutrient deficiencies in patients with radiation cystitis and outcome after hyperbaric oxygen therapy. ( 29460790 )
2018
3
Changes in the Neuronal Control of the Urinary Bladder in a Model of Radiation Cystitis. ( 29530925 )
2018
4
Correlation between urinary dose and delayed radiation cystitis after 78A Gy intensity-modulated radiotherapy for high-risk prostate cancer: A 10-year follow-up study of genitourinary toxicity in clinical practice. ( 29594221 )
2017
5
Hyperbaric, Radiation Cystitis ( 29261976 )
2017
6
Cumulative incidence and predictive factors of radiation cystitis in patients with localized prostate cancer. ( 29169704 )
2017
7
Ureteral Embolization to Prevent Thrombotic Obstruction of Nephrostomy Catheters in the Context of Refractory Hemorrhagic Radiation Cystitis with Severe Vesicoureteral Reflux. ( 27019759 )
2016
8
Hyperbaric Oxygen Therapy for Radiation Cystitis. ( 27637115 )
2016
9
Intravesical Liposomal Tacrolimus Protects Against Radiation Cystitis Induced by 3-Beam Targeted Bladder Radiation. ( 25839382 )
2015
10
Innovative use of intravesical tacrolimus for hemorrhagic radiation cystitis. ( 26347076 )
2015
11
A Narrative Review on the Pathophysiology and Management for Radiation Cystitis. ( 26798335 )
2015
12
Modeling and Treatment of Radiation Cystitis. ( 26571081 )
2015
13
Sodium hyaluronate and chondroitin sulfate replenishment therapy can improve nocturia in men with post-radiation cystitis: results of a prospective pilot study. ( 26148853 )
2015
14
Advances in Therapeutic Development for Radiation Cystitis. ( 26663493 )
2014
15
Successful use of endoscopic argon plasma coagulation for hemorrhagic radiation cystitis: a case report. ( 24837598 )
2014
16
Early urinary diversion with ileal conduit and vesicovaginostomy in the treatment of radiation cystitis due to carcinoma cervix: a study from a tertiary care hospital in South India. ( 25366250 )
2014
17
Standardized cranberry capsules for radiation cystitis in prostate cancer patients in New Zealand: a randomized double blinded, placebo controlled pilot study. ( 24993395 )
2014
18
Evaluation of the impact of the urinary symptoms on quality of life of patients with painful bladder syndrome/chronic pelvic pain and radiation cystitis: EURCIS study. ( 24360594 )
2013
19
Hyperbaric oxygen therapy for hemorrhagic radiation cystitis. ( 23516773 )
2013
20
Hyperbaric oxygen therapy for hemorrhagic radiation cystitis. ( 23516766 )
2013
21
Hemorrhagic Radiation Cystitis. ( 24322335 )
2013
22
Radiation cystitis with pseudocarcinomatous urothelial hyperplasia. ( 24045222 )
2013
23
Possible risk factors associated with radiation proctitis or radiation cystitis in patients with cervical carcinoma after radiotherapy. ( 23464440 )
2012
24
A cost-analysis case study of radiation cystitis treatment including hyperbaric oxygen therapy. ( 22828818 )
2012
25
Hyperbaric oxygen therapy for radiation cystitis in patients with prostate cancer: a long-term follow-up study. ( 22797611 )
2012
26
Vascular therapy for radiation cystitis. ( 21412823 )
2011
27
Treatment of acute radiation cystitis: comment. ( 21739326 )
2011
28
Prophylactic vesical instillations with 0.2% chondroitin sulfate may reduce symptoms of acute radiation cystitis in patients undergoing radiotherapy for gynecological malignancies. ( 21365332 )
2011
29
Recombinant activated factor VII to control life-threatening haemorrhagic radiation cystitis. ( 19352582 )
2010
30
Management of radiation cystitis. ( 20212517 )
2010
31
Efficacy of sodium hyaluronate in the management of chemical and radiation cystitis. ( 20562794 )
2010
32
Is treatment of hemorrhagic radiation cystitis with hyperbaric oxygen effective? ( 20224264 )
2010
33
Radiation cystitis: indication for hyperbaric oxygen. ( 18325711 )
2009
34
Radiation cystitis. ( 19625037 )
2009
35
A new minimally invasive technique for treating radiation cystitis: the argon-beam coagulator. ( 16925761 )
2006
36
A phase II study to evaluate WF10 in patients with late hemorrhagic radiation cystitis and proctitis. ( 16169580 )
2006
37
Sexual function after partial cystectomy and urothelial stripping in a 32-year-old woman with radiation cystitis. ( 15647882 )
2005
38
Reduced recurrence of late hemorrhagic radiation cystitis by WF10 therapy in cervical cancer patients: a multicenter, randomized, two-arm, open-label trial. ( 15542165 )
2004
39
Rupture of urachal diverticulum in radiation cystitis and neurogenic bladder dysfunction after radical hysterectomy. ( 15479303 )
2004
40
Non-surgical interventions for late radiation cystitis in patients who have received radical radiotherapy to the pelvis. ( 12137633 )
2002
41
Intravesicle formalin instillation with a modified technique for controlling haemorrhage secondary to radiation cystitis. ( 12376221 )
2002
42
Hyperbaric oxygen for the treatment of radiation cystitis and proctitis. ( 12084193 )
2002
43
Successful treatment of radiation cystitis with hyperbaric oxygen therapy: resolution of bleeding event and changes of histopathological findings of the bladder mucosa. ( 9696331 )
1998
44
Endoscopic topical placement of formalin soaked pledgets to control localized hemorrhage due to radiation cystitis. ( 9224340 )
1997
45
Effective hyperbaric oxygenation with prostaglandin E1 for radiation cystitis and colitis after pelvic radiotherapy. ( 9061423 )
1996
46
Hyperbaric oxygen treatment for haemorrhagic radiation cystitis. ( 7674746 )
1995
47
Bladder peptic ulcer after gastrocystoplasty for radiation cystitis. ( 8015094 )
1994
48
Abnormal sensitivity to intravesical potassium in interstitial cystitis and radiation cystitis. ( 7833969 )
1994
49
Hyperbaric oxygen therapy in hemorrhagic radiation cystitis: a report of 20 cases. ( 7950806 )
1994
50
Hyperbaric oxygen treatment of radiation cystitis. ( 8324997 )
1993

Variations for Radiation Cystitis

Expression for Radiation Cystitis

Search GEO for disease gene expression data for Radiation Cystitis.

Pathways for Radiation Cystitis

GO Terms for Radiation Cystitis

Cellular components related to Radiation Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 8.8 CACNA1C NOS1 TCAP

Biological processes related to Radiation Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 8.8 F7 HMOX1 NOS1

Molecular functions related to Radiation Cystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 8.62 IL13 MIF

Sources for Radiation Cystitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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