MCID: RDT013
MIFTS: 50

Radiation Proctitis

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Radiation Proctitis

MalaCards integrated aliases for Radiation Proctitis:

Name: Radiation Proctitis 59 73

Characteristics:

Orphanet epidemiological data:

59
radiation proctitis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult;

Classifications:



External Ids:

Orphanet 59 ORPHA70475
UMLS via Orphanet 74 C0400827
ICD10 via Orphanet 34 K62.7
ICD10 33 K62.7
UMLS 73 C0400827

Summaries for Radiation Proctitis

MalaCards based summary : Radiation Proctitis is related to proctitis and superficial siderosis of the central nervous system. An important gene associated with Radiation Proctitis is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are Pathways in cancer and MAPK signaling pathway. The drugs Sucralfate and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and endothelial, and related phenotypes are hematochezia and abnormality of connective tissue

Wikipedia : 76 Radiation proctitis (and the related radiation colitis) is inflammation and damage to the lower parts of... more...

Related Diseases for Radiation Proctitis

Diseases related to Radiation Proctitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 proctitis 29.9 ENTPD1 FGF2 KDR LTF TNF
2 superficial siderosis of the central nervous system 10.6 LTF TF
3 melancholia 10.6 TF TNF
4 superficial siderosis 10.6 LTF TF
5 hemangioendothelioma 10.6 KDR PECAM1
6 kaposiform hemangioendothelioma 10.6 KDR PECAM1
7 pulmonary vein stenosis 10.6 KDR PECAM1
8 rheumatoid vasculitis 10.5 LTF TNF
9 senile angioma 10.5 KDR TF
10 laryngitis 10.5 FGF2 TNF
11 critical limb ischemia 10.4 TNF VEGFA
12 diverticulitis 10.4 FGF2 TNF
13 hydrocele 10.4 PECAM1 VEGFA
14 poems syndrome 10.4 TNF VEGFA
15 angiokeratoma circumscriptum 10.3 KDR VEGFA
16 soft tissue sarcoma 10.3 TNF VEGFA
17 prostatitis 10.3
18 lymphangiosarcoma 10.3 TNF VEGFA
19 dysentery 10.3 LTF TF
20 haemophilus influenzae 10.3 LTF TF TNF
21 skin hemangioma 10.3 KDR VEGFA
22 kuhnt-junius degeneration 10.2 KDR VEGFA
23 chronic myocardial ischemia 10.2 FGF2 VEGFA
24 prostate cancer 10.2
25 angiodysplasia 10.2 FGF2 VEGFA
26 tuberculous meningitis 10.2 TNF VEGFA
27 acute hemorrhagic leukoencephalitis 10.2 KDR VEGFA
28 rosacea 10.2 TNF VEGFA
29 leukostasis 10.2 KDR VEGFA
30 lymphangioma 10.1 KDR VEGFA
31 dupuytren contracture 10.1 FGF2 VEGFA
32 dry eye syndrome 10.1 FGF2 LTF TNF
33 vitreous disease 10.1 FGF2 VEGFA
34 eales disease 10.1 TF TNF VEGFA
35 endotheliitis 10.1
36 capillary hemangioma 10.0 KDR PECAM1 VEGFA
37 epithelioid hemangioendothelioma 10.0 KDR PECAM1 VEGFA
38 coats disease 10.0 KDR VEGFA
39 angiosarcoma 10.0 KDR PECAM1 VEGFA
40 geographic tongue 10.0 TNF VEGFA
41 cervicitis 10.0
42 juvenile nasopharyngeal angiofibroma 10.0 FGF2 PECAM1 VEGFA
43 commensal bacterial infectious disease 10.0 EDNRB TNF
44 hemorrhoid 9.9
45 suppressor of tumorigenicity 3 9.9
46 gastric antral vascular ectasia 9.9
47 gastrointestinal system disease 9.9 EDNRB LTF TNF
48 kaposi sarcoma 9.9 FGF2 TNF VEGFA
49 thyroid cancer, nonmedullary, 2 9.9 AOC1 EDNRB KDR
50 vascular cancer 9.8 FGF2 KDR VEGFA

Graphical network of the top 20 diseases related to Radiation Proctitis:



Diseases related to Radiation Proctitis

Symptoms & Phenotypes for Radiation Proctitis

Human phenotypes related to Radiation Proctitis:

59 32 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hematochezia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002573
2 abnormality of connective tissue 59 32 hallmark (90%) Very frequent (99-80%) HP:0003549
3 abnormality of gastrointestinal vasculature 59 32 hallmark (90%) Very frequent (99-80%) HP:0004296
4 rectal abscess 59 32 hallmark (90%) Very frequent (99-80%) HP:0005224
5 rectal fistula 59 32 hallmark (90%) Very frequent (99-80%) HP:0100590
6 intestinal obstruction 59 32 occasional (7.5%) Occasional (29-5%) HP:0005214
7 arteritis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012089
8 tenesmus 59 32 occasional (7.5%) Occasional (29-5%) HP:0012702
9 sepsis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100806
10 abnormality of the rectum 59 Very frequent (99-80%)
11 abnormality of the vasculature 59 Very frequent (99-80%)
12 abnormal vascular morphology 59 Very frequent (99-80%)
13 diarrhea 59 Occasional (29-5%)

GenomeRNAi Phenotypes related to Radiation Proctitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with carboplatin GR00207-A-11 8.92 ENTPD1
2 Decreased viability with carboplatin GR00207-A-7 8.92 EDNRA ENTPD1
3 Decreased viability with carboplatin GR00207-A-9 8.92 EDNRA

MGI Mouse Phenotypes related to Radiation Proctitis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.22 TF TNF VEGFA AOC1 EDNRA EDNRB
2 homeostasis/metabolism MP:0005376 10.2 AOC1 EDNRA EDNRB ENTPD1 FGF2 KDR
3 cardiovascular system MP:0005385 10.18 AOC1 EDNRA EDNRB ENTPD1 FGF2 KDR
4 behavior/neurological MP:0005386 10.14 EDNRB ENTPD1 FGF2 KDR TNF VEGFA
5 cellular MP:0005384 10.11 EDNRA EDNRB FGF2 KDR LTF PECAM1
6 immune system MP:0005387 10.03 EDNRA EDNRB ENTPD1 KDR LTF PECAM1
7 muscle MP:0005369 9.97 EDNRA EDNRB ENTPD1 FGF2 KDR PECAM1
8 craniofacial MP:0005382 9.89 KDR TNF VEGFA EDNRA EDNRB
9 liver/biliary system MP:0005370 9.88 ENTPD1 KDR LTF PECAM1 TNF VEGFA
10 neoplasm MP:0002006 9.72 EDNRB FGF2 LTF TNF VEGFA
11 respiratory system MP:0005388 9.7 EDNRA EDNRB ENTPD1 KDR PECAM1 TNF
12 renal/urinary system MP:0005367 9.65 EDNRA EDNRB ENTPD1 PECAM1 VEGFA
13 skeleton MP:0005390 9.56 ENTPD1 FGF2 KDR PECAM1 TNF VEGFA
14 vision/eye MP:0005391 9.23 VEGFA AOC1 EDNRA EDNRB ENTPD1 FGF2

Drugs & Therapeutics for Radiation Proctitis

Drugs for Radiation Proctitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sucralfate Approved Phase 4 54182-58-0 0
2 Gastrointestinal Agents Phase 4
3 Antacids Phase 4
4 Anti-Ulcer Agents Phase 4
5
Inulin Approved, Investigational, Nutraceutical Phase 3 9005-80-5 24763
6 Acidophilus Nutraceutical Phase 2, Phase 3
7
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
8
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
9
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
10
Bisacodyl Approved Phase 2 603-50-9
11
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741
12
Budesonide Approved Phase 2 51333-22-3 63006 5281004
13 Orange Approved, Nutraceutical Phase 2
14 glucocorticoids Phase 2
15 Respiratory System Agents Phase 2
16 Hormone Antagonists Phase 2
17 Hormones Phase 2
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
19 Anti-Asthmatic Agents Phase 2
20 Peripheral Nervous System Agents Phase 2
21 Anti-Inflammatory Agents Phase 2
22 Autonomic Agents Phase 2
23 Bronchodilator Agents Phase 2
24 Cola Nutraceutical Phase 2,Not Applicable
25 Anesthetics Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Combined Therapy in Radiation Proctopathy Completed NCT01613534 Phase 4 Sucralfate;Placebo
2 CryoSpray Ablation(TM)to Determine Safety and Feasibility in Radiation Induced Proctitis Withdrawn NCT00756197 Phase 4
3 Study to Prevent Radiation Induced Damage to Bowel Using a Prebiotic Enhanced Diet. Unknown status NCT01414517 Phase 3
4 Efficacy of Symbiotic in the Reduction of Acute Radiation Proctitis Symptoms Completed NCT01901042 Phase 2, Phase 3
5 Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial. Completed NCT02104271 Phase 2
6 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Recruiting NCT03302858 Phase 2
7 Brachytherapy for Recurrent Prostate Cancer Active, not recruiting NCT01956058 Phase 2
8 Budesonide Foam Versus Placebo for Prevention of Acute Radiation Proctitis Terminated NCT00828230 Phase 2 budesonide;Placebo foam
9 Trial of Argon Plasma Coagulation Versus APC and APC and Hemospray in the Treatment of Radiation Proctitis Unknown status NCT02233933 Not Applicable
10 Treatment of Hemorrhagic Radiation Proctitis Using the Halo System Completed NCT01103492 Not Applicable
11 Causes of Low Digestive Bleeding in Proctology Completed NCT02846285
12 Transverse Colostomy for Refractory Hemorrhagic Chronic Radiation Proctitis: a Prospective Cohort Study Not yet recruiting NCT03397901 Not Applicable

Search NIH Clinical Center for Radiation Proctitis

Genetic Tests for Radiation Proctitis

Anatomical Context for Radiation Proctitis

MalaCards organs/tissues related to Radiation Proctitis:

41
Prostate, Colon, Endothelial, Cervix

Publications for Radiation Proctitis

Articles related to Radiation Proctitis:

(show top 50) (show all 184)
# Title Authors Year
1
Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats. ( 29768539 )
2018
2
Long extensive radiation proctitis treated with rectal band ligation (with video). ( 29884558 )
2018
3
Management of Radiation Proctitis. ( 29948565 )
2018
4
Role of Angiogenesis in Chronic Radiation Proctitis: New Evidence Favoring Inhibition of Angiogenesis Ex Vivo. ( 29080145 )
2018
5
Evaluation of prophylactic and therapeutic effects of ruscogenin on acute radiation proctitis: an experimental rat model. ( 29629351 )
2018
6
Correlation between Disease Activity and Endorectal Ultrasound Findings of Chronic Radiation Proctitis. ( 28755790 )
2017
7
Expression of Vascular Endothelial Growth Factor (VEGF) and its Correlation with Clinical Symptoms and Endoscopic Findings in Patients with Chronic Radiation Proctitis. ( 28963746 )
2017
8
Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice. ( 28694461 )
2017
9
Endoscopic diode laser therapy for chronic radiation proctitis. ( 28895000 )
2017
10
Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial. ( 28618234 )
2017
11
Efficacy and safety of argon plasma coagulation in the management of extensive chronic radiation proctitis after pelvic radiotherapy for cervical carcinoma. ( 28707144 )
2017
12
Radiofrequency ablation for gastric antral vascular ectasia and radiation proctitis. ( 28367587 )
2017
13
Chronic haemorrhagic radiation proctitis: A review. ( 27462390 )
2016
14
Exploring the Management of Radiation Proctitis in Current Clinical Practice. ( 27504391 )
2016
15
Novel and Effective Almagate Enema for Hemorrhagic Chronic Radiation Proctitis and Risk Factors for Fistula Development. ( 26925655 )
2016
16
Complication and remission rates after endoscopic argon plasma coagulation in the treatment of haemorrhagic radiation proctitis. ( 27527929 )
2016
17
Impact of treatment time-related factors on prognoses and radiation proctitis after definitive chemoradiotherapy for cervical cancer. ( 27416796 )
2016
18
Long-term results on the efficacy of argon plasma coagulation for patients with chronic radiation proctitis after conventionally fractionated, dose-escalated radiation therapy for prostate cancer. ( 27663931 )
2016
19
Colostomy is a simple and effective procedure for severe chronic radiation proctitis. ( 27350738 )
2016
20
Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis. ( 26185013 )
2015
21
Effects of human amnion-derived mesenchymal stromal cell transplantation in rats with radiation proctitis. ( 26256683 )
2015
22
Formalin therapy for hemorrhagic radiation proctitis. ( 26398382 )
2015
23
Formalin irrigation for hemorrhagic chronic radiation proctitis. ( 25834325 )
2015
24
Can Angiotensin-Converting Enzyme Inhibitors Reduce the Incidence, Severity, and Duration of Radiation Proctitis? ( 26547382 )
2015
25
Minimally invasive treatment of radiation proctitis and piles - a video vignette. ( 26382829 )
2015
26
The Efficacy of Probiotic (Lactobacillus rhamnosus GG) and 5-ASA (Aminosalicylic Acid) in the Treatment of Experimental Radiation Proctitis in Rats. ( 26730065 )
2015
27
Osteopontin Knockout Does Not Influence the Severity of Rectal Damage in a Preclinical Model of Radiation Proctitis in Mice. ( 25577272 )
2015
28
Chronic radiation proctitis: tricks to prevent and treat. ( 26198994 )
2015
29
Dual-modal ablation treatment for refractory radiation proctitis. ( 26272198 )
2015
30
Cryotherapy for treatment of radiation proctitis. ( 24140130 )
2014
31
Is argon plasma coagulation an effective and safe treatment option for patients with chronic radiation proctitis after high doses of radiotherapy? ( 25007015 )
2014
32
Efficacy of synbiotics to reduce acute radiation proctitis symptoms and improve quality of life: a randomized, double-blind, placebo-controlled pilot trial. ( 25304789 )
2014
33
Daily sodium butyrate enema for the prevention of radiation proctitis in prostate cancer patients undergoing radical radiation therapy: results of a multicenter randomized placebo-controlled dose-finding phase 2 study. ( 24803033 )
2014
34
Radiofrequency ablation for the treatment of radiation proctitis. ( 25290097 )
2014
35
Radiofrequency ablation for chronic radiation proctitis: our initial experience with four cases. ( 24915942 )
2014
36
Argon gas in the management of radiation proctitis--effective and safe for everyone? ( 25007013 )
2014
37
Successful management using endoclips of rectal perforation during retroflexion in a patient with radiation proctitis. ( 23526525 )
2013
38
Early treatment and prevention of the radiation proctitis--composite enemas containing sodium butyrate. ( 23516076 )
2013
39
Effects of ozonated olive oil on acute radiation proctitis in rats. ( 25207143 )
2013
40
Increased expression of VEGF and CD31 in postradiation rectal tissue: implications for radiation proctitis. ( 23737650 )
2013
41
Endoscopic treatments for chronic radiation proctitis. ( 23858374 )
2013
42
Sucralfate or placebo following argon plasma coagulation for chronic radiation proctitis: a randomized double blind trial. ( 23006660 )
2013
43
Management of radiation proctitis. ( 24280407 )
2013
44
Radiofrequency ablation for the treatment of radiation proctitis: a case report and review of literature. ( 23320051 )
2013
45
Clinical and proctoscopic evaluation of topical formalin application in the treatment of chronic radiation proctitis. ( 23820684 )
2013
46
Efficacy of cryospray ablation for the treatment of chronic radiation proctitis in a pilot study. ( 23362977 )
2013
47
Long-term control of refractory hemorrhagic radiation proctitis with ozone therapy. ( 23102757 )
2013
48
Protective role of antiplatelet treatment against ulcer formation due to argon plasma coagulation in patients treated for chronic radiation proctitis. ( 24138319 )
2013
49
Management of Radiation Proctitis. ( 23241500 )
2013
50
A cure for post-radiation proctitis? ( 23736909 )
2013

Variations for Radiation Proctitis

Expression for Radiation Proctitis

Search GEO for disease gene expression data for Radiation Proctitis.

Pathways for Radiation Proctitis

GO Terms for Radiation Proctitis

Cellular components related to Radiation Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 AOC1 FGF2 KDR LTF TF TNF
2 cell surface GO:0009986 9.62 LTF TF TNF VEGFA
3 extracellular space GO:0005615 9.5 AOC1 FGF2 LTF PECAM1 TF TNF
4 signal recognition particle receptor complex GO:0005785 9.16 LTF TF
5 membrane raft GO:0045121 8.92 EDNRB KDR PECAM1 TNF

Biological processes related to Radiation Proctitis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.9 EDNRB KDR LTF VEGFA
2 positive regulation of cell proliferation GO:0008284 9.88 EDNRB FGF2 KDR VEGFA
3 angiogenesis GO:0001525 9.79 FGF2 KDR VEGFA
4 negative regulation of gene expression GO:0010629 9.78 KDR TNF VEGFA
5 positive regulation of angiogenesis GO:0045766 9.71 FGF2 KDR VEGFA
6 platelet degranulation GO:0002576 9.69 PECAM1 TF VEGFA
7 extracellular matrix organization GO:0030198 9.67 FGF2 KDR PECAM1 TNF
8 positive regulation of endothelial cell proliferation GO:0001938 9.63 FGF2 KDR VEGFA
9 iron ion homeostasis GO:0055072 9.61 LTF TF
10 positive regulation of MAP kinase activity GO:0043406 9.61 FGF2 TNF VEGFA
11 branching involved in blood vessel morphogenesis GO:0001569 9.59 EDNRA VEGFA
12 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.58 KDR VEGFA
13 positive regulation of sprouting angiogenesis GO:1903672 9.57 FGF2 VEGFA
14 positive regulation of focal adhesion assembly GO:0051894 9.56 KDR VEGFA
15 positive regulation of protein phosphorylation GO:0001934 9.56 EDNRB KDR TNF VEGFA
16 positive regulation of protein complex assembly GO:0031334 9.55 TNF VEGFA
17 vasoconstriction GO:0042310 9.52 EDNRA EDNRB
18 positive regulation of blood vessel endothelial cell migration GO:0043536 9.5 FGF2 KDR VEGFA
19 positive regulation of positive chemotaxis GO:0050927 9.49 KDR VEGFA
20 enteric nervous system development GO:0048484 9.48 EDNRA EDNRB
21 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.4 KDR VEGFA
22 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.33 FGF2 KDR VEGFA
23 endothelin receptor signaling pathway GO:0086100 8.96 EDNRA EDNRB
24 cell migration involved in sprouting angiogenesis GO:0002042 8.8 FGF2 KDR VEGFA

Molecular functions related to Radiation Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 FGF2 TNF VEGFA
2 chemoattractant activity GO:0042056 9.32 FGF2 VEGFA
3 heparin binding GO:0008201 9.26 AOC1 FGF2 LTF VEGFA
4 signal recognition particle binding GO:0005047 9.16 LTF TF
5 endothelin receptor activity GO:0004962 8.62 EDNRA EDNRB

Sources for Radiation Proctitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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