MCID: RDT013
MIFTS: 52

Radiation Proctitis

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Radiation Proctitis

MalaCards integrated aliases for Radiation Proctitis:

Name: Radiation Proctitis 59 73

Characteristics:

Orphanet epidemiological data:

59
radiation proctitis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult;

Classifications:



External Ids:

Orphanet 59 ORPHA70475
UMLS via Orphanet 74 C0400827
ICD10 via Orphanet 34 K62.7
ICD10 33 K62.7
UMLS 73 C0400827

Summaries for Radiation Proctitis

MalaCards based summary : Radiation Proctitis is related to proctitis and prostate cancer. An important gene associated with Radiation Proctitis is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are Pathways in cancer and MAPK signaling pathway. Affiliated tissues include prostate, colon and skin, and related phenotypes are intestinal obstruction and sepsis

Wikipedia : 76 Radiation proctitis (and the related radiation colitis) is inflammation and damage to the lower parts of... more...

Related Diseases for Radiation Proctitis

Diseases related to Radiation Proctitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 proctitis 30.8 ENTPD1 FGF2 KDR LTF TNF
2 prostate cancer 10.4
3 bullous impetigo 10.2 EDNRA EDNRB
4 perinephritis 10.2 EDNRA EDNRB
5 ritter's disease 10.2 EDNRA EDNRB
6 scarlet fever 10.2 EDNRA EDNRB
7 hemangioendothelioma 10.2 KDR PECAM1
8 kaposiform hemangioendothelioma 10.2 KDR PECAM1
9 pulmonary vein stenosis 10.2 KDR PECAM1
10 chronic myocardial ischemia 10.1 FGF2 VEGFA
11 angiodysplasia 10.1 FGF2 VEGFA
12 vitreous disease 10.1 FGF2 VEGFA
13 dupuytren contracture 10.1 FGF2 VEGFA
14 angiokeratoma circumscriptum 10.1 KDR VEGFA
15 senile angioma 10.1 KDR TF
16 skin hemangioma 10.1 KDR VEGFA
17 epithelioid hemangioendothelioma 10.1 KDR VEGFA
18 drug-induced lupus erythematosus 10.1 KDR VEGFA
19 juvenile nasopharyngeal angiofibroma 10.0 FGF2 PECAM1 VEGFA
20 suppressor of tumorigenicity 3 10.0
21 gastric antral vascular ectasia 10.0
22 hemorrhoid 10.0
23 leukostasis 10.0 KDR VEGFA
24 superficial siderosis 10.0 LTF TF
25 superficial siderosis of the central nervous system 10.0 LTF TF
26 lymphangioma 10.0 KDR VEGFA
27 thyroid cancer, nonmedullary, 2 10.0 AOC1 EDNRB KDR
28 diabetic macular edema 10.0 FGF2 VEGFA
29 coats disease 10.0 KDR VEGFA
30 laryngitis 10.0 FGF2 TNF
31 vernal conjunctivitis 10.0 AOC1 TF
32 capillary hemangioma 10.0 KDR PECAM1 VEGFA
33 angiosarcoma 10.0 KDR PECAM1 VEGFA
34 autosomal dominant polycystic kidney disease 10.0 EDNRA EDNRB VEGFA
35 diverticulitis 10.0 FGF2 TNF
36 vascular cancer 10.0 FGF2 KDR VEGFA
37 corneal neovascularization 10.0 FGF2 KDR VEGFA
38 microvascular complications of diabetes 5 10.0 FGF2 KDR VEGFA
39 kaposi sarcoma 10.0 FGF2 KDR VEGFA
40 critical limb ischemia 10.0 TNF VEGFA
41 kashin-beck disease 9.9 TNF VEGFA
42 melancholia 9.9 TF TNF
43 dysentery 9.9 LTF TF
44 poems syndrome 9.9 TNF VEGFA
45 soft tissue sarcoma 9.9 TNF VEGFA
46 cervical cancer 9.9
47 cystitis 9.9
48 rectal neoplasm 9.9
49 radiation cystitis 9.9
50 fournier gangrene 9.9

Graphical network of the top 20 diseases related to Radiation Proctitis:



Diseases related to Radiation Proctitis

Symptoms & Phenotypes for Radiation Proctitis

Human phenotypes related to Radiation Proctitis:

59 32 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 intestinal obstruction 59 32 occasional (7.5%) Occasional (29-5%) HP:0005214
2 sepsis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100806
3 hematochezia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002573
4 abnormality of connective tissue 59 32 hallmark (90%) Very frequent (99-80%) HP:0003549
5 rectal abscess 59 32 hallmark (90%) Very frequent (99-80%) HP:0005224
6 rectal fistula 59 32 hallmark (90%) Very frequent (99-80%) HP:0100590
7 arteritis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012089
8 abnormality of gastrointestinal vasculature 59 32 hallmark (90%) Very frequent (99-80%) HP:0004296
9 tenesmus 59 32 occasional (7.5%) Occasional (29-5%) HP:0012702
10 abnormality of the vasculature 59 Very frequent (99-80%)
11 diarrhea 59 Occasional (29-5%)
12 abnormality of the rectum 59 Very frequent (99-80%)
13 abnormal vascular morphology 59 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Radiation Proctitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with carboplatin GR00207-A-11 8.92 ENTPD1
2 Decreased viability with carboplatin GR00207-A-7 8.92 EDNRA ENTPD1
3 Decreased viability with carboplatin GR00207-A-9 8.92 EDNRA

MGI Mouse Phenotypes related to Radiation Proctitis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.22 AOC1 EDNRA EDNRB ENTPD1 FGF2 KDR
2 homeostasis/metabolism MP:0005376 10.2 AOC1 EDNRA EDNRB ENTPD1 FGF2 KDR
3 cardiovascular system MP:0005385 10.18 AOC1 EDNRA EDNRB ENTPD1 FGF2 KDR
4 behavior/neurological MP:0005386 10.14 AOC1 EDNRA EDNRB ENTPD1 FGF2 KDR
5 cellular MP:0005384 10.11 EDNRA EDNRB FGF2 KDR LTF PECAM1
6 immune system MP:0005387 10.03 EDNRA EDNRB ENTPD1 KDR LTF PECAM1
7 muscle MP:0005369 9.97 EDNRA EDNRB ENTPD1 FGF2 KDR PECAM1
8 craniofacial MP:0005382 9.89 EDNRA EDNRB KDR TNF VEGFA
9 liver/biliary system MP:0005370 9.88 ENTPD1 KDR LTF PECAM1 TNF VEGFA
10 neoplasm MP:0002006 9.72 EDNRB FGF2 LTF TNF VEGFA
11 respiratory system MP:0005388 9.7 EDNRA EDNRB ENTPD1 KDR PECAM1 TNF
12 renal/urinary system MP:0005367 9.65 EDNRA EDNRB ENTPD1 PECAM1 VEGFA
13 skeleton MP:0005390 9.56 EDNRA EDNRB ENTPD1 FGF2 KDR PECAM1
14 vision/eye MP:0005391 9.23 AOC1 EDNRA EDNRB ENTPD1 FGF2 KDR

Drugs & Therapeutics for Radiation Proctitis

Search Clinical Trials , NIH Clinical Center for Radiation Proctitis

Genetic Tests for Radiation Proctitis

Anatomical Context for Radiation Proctitis

MalaCards organs/tissues related to Radiation Proctitis:

41
Prostate, Colon, Skin, Brain, Kidney, Eye, Thyroid

Publications for Radiation Proctitis

Articles related to Radiation Proctitis:

(show top 50) (show all 192)
# Title Authors Year
1
Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats. ( 29768539 )
2018
2
Long extensive radiation proctitis treated with rectal band ligation (with video). ( 29884558 )
2018
3
Management of Radiation Proctitis. ( 29948565 )
2018
4
Role of Angiogenesis in Chronic Radiation Proctitis: New Evidence Favoring Inhibition of Angiogenesis Ex Vivo. ( 29080145 )
2018
5
Evaluation of prophylactic and therapeutic effects of ruscogenin on acute radiation proctitis: an experimental rat model. ( 29629351 )
2018
6
International validation of the EORTC QLQ-PRT20 module for assessment of quality of life symptoms relating to radiation proctitis: a phase IV study. ( 30157890 )
2018
7
Mesalazine suppository for the treatment of refractory ulcerative chronic radiation proctitis. ( 30186474 )
2018
8
Comparison of relative and absolute rectal dose-volume parameters and clinical correlation with acute and late radiation proctitis in prostate cancer patients. ( 30191285 )
2018
9
The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Chronic Radiation Proctitis. ( 30192320 )
2018
10
The role of endoscopic evaluation for radiation proctitis in patients receiving intermediate-dose postoperative radiotherapy for rectal cancer. ( 30239826 )
2018
11
Correlation between Disease Activity and Endorectal Ultrasound Findings of Chronic Radiation Proctitis. ( 28755790 )
2017
12
Expression of Vascular Endothelial Growth Factor (VEGF) and its Correlation with Clinical Symptoms and Endoscopic Findings in Patients with Chronic Radiation Proctitis. ( 28963746 )
2017
13
Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice. ( 28694461 )
2017
14
Endoscopic diode laser therapy for chronic radiation proctitis. ( 28895000 )
2017
15
Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial. ( 28618234 )
2017
16
Efficacy and safety of argon plasma coagulation in the management of extensive chronic radiation proctitis after pelvic radiotherapy for cervical carcinoma. ( 28707144 )
2017
17
Radiofrequency ablation for gastric antral vascular ectasia and radiation proctitis. ( 28367587 )
2017
18
Chronic haemorrhagic radiation proctitis: A review. ( 27462390 )
2016
19
Exploring the Management of Radiation Proctitis in Current Clinical Practice. ( 27504391 )
2016
20
Novel and Effective Almagate Enema for Hemorrhagic Chronic Radiation Proctitis and Risk Factors for Fistula Development. ( 26925655 )
2016
21
Complication and remission rates after endoscopic argon plasma coagulation in the treatment of haemorrhagic radiation proctitis. ( 27527929 )
2016
22
Impact of treatment time-related factors on prognoses and radiation proctitis after definitive chemoradiotherapy for cervical cancer. ( 27416796 )
2016
23
Long-term results on the efficacy of argon plasma coagulation for patients with chronic radiation proctitis after conventionally fractionated, dose-escalated radiation therapy for prostate cancer. ( 27663931 )
2016
24
Colostomy is a simple and effective procedure for severe chronic radiation proctitis. ( 27350738 )
2016
25
Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis. ( 26185013 )
2015
26
Effects of human amnion-derived mesenchymal stromal cell transplantation in rats with radiation proctitis. ( 26256683 )
2015
27
Formalin therapy for hemorrhagic radiation proctitis. ( 26398382 )
2015
28
Formalin irrigation for hemorrhagic chronic radiation proctitis. ( 25834325 )
2015
29
Can Angiotensin-Converting Enzyme Inhibitors Reduce the Incidence, Severity, and Duration of Radiation Proctitis? ( 26547382 )
2015
30
Minimally invasive treatment of radiation proctitis and piles - a video vignette. ( 26382829 )
2015
31
The Efficacy of Probiotic (Lactobacillus rhamnosus GG) and 5-ASA (Aminosalicylic Acid) in the Treatment of Experimental Radiation Proctitis in Rats. ( 26730065 )
2015
32
Osteopontin Knockout Does Not Influence the Severity of Rectal Damage in a Preclinical Model of Radiation Proctitis in Mice. ( 25577272 )
2015
33
Chronic radiation proctitis: tricks to prevent and treat. ( 26198994 )
2015
34
Dual-modal ablation treatment for refractory radiation proctitis. ( 26272198 )
2015
35
Cryotherapy for treatment of radiation proctitis. ( 24140130 )
2014
36
Is argon plasma coagulation an effective and safe treatment option for patients with chronic radiation proctitis after high doses of radiotherapy? ( 25007015 )
2014
37
Efficacy of synbiotics to reduce acute radiation proctitis symptoms and improve quality of life: a randomized, double-blind, placebo-controlled pilot trial. ( 25304789 )
2014
38
Daily sodium butyrate enema for the prevention of radiation proctitis in prostate cancer patients undergoing radical radiation therapy: results of a multicenter randomized placebo-controlled dose-finding phase 2 study. ( 24803033 )
2014
39
Radiofrequency ablation for the treatment of radiation proctitis. ( 25290097 )
2014
40
Radiofrequency ablation for chronic radiation proctitis: our initial experience with four cases. ( 24915942 )
2014
41
Argon gas in the management of radiation proctitis--effective and safe for everyone? ( 25007013 )
2014
42
Sucralfate paste enema: a new method of topical treatment for haemorrhagic radiation proctitis. ( 24299100 )
2014
43
Successful management using endoclips of rectal perforation during retroflexion in a patient with radiation proctitis. ( 23526525 )
2013
44
Early treatment and prevention of the radiation proctitis--composite enemas containing sodium butyrate. ( 23516076 )
2013
45
Effects of ozonated olive oil on acute radiation proctitis in rats. ( 25207143 )
2013
46
Increased expression of VEGF and CD31 in postradiation rectal tissue: implications for radiation proctitis. ( 23737650 )
2013
47
Endoscopic treatments for chronic radiation proctitis. ( 23858374 )
2013
48
Sucralfate or placebo following argon plasma coagulation for chronic radiation proctitis: a randomized double blind trial. ( 23006660 )
2013
49
Management of radiation proctitis. ( 24280407 )
2013
50
Radiofrequency ablation for the treatment of radiation proctitis: a case report and review of literature. ( 23320051 )
2013

Variations for Radiation Proctitis

Expression for Radiation Proctitis

Search GEO for disease gene expression data for Radiation Proctitis.

Pathways for Radiation Proctitis

Pathways related to Radiation Proctitis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1 12.58 EDNRA EDNRB FGF2 VEGFA
2 12.48 FGF2 KDR TNF VEGFA
3 12.01 FGF2 KDR TNF VEGFA
4
Show member pathways
11.98 FGF2 KDR VEGFA
5 11.92 TF TNF VEGFA
6 11.79 FGF2 KDR VEGFA
7 11.69 FGF2 TNF VEGFA
8 11.56 FGF2 KDR PECAM1
9 11.4 KDR PECAM1 TNF VEGFA
10 11.23 FGF2 KDR VEGFA
11 11.18 FGF2 TF VEGFA
12 11.12 EDNRA EDNRB
13 11.12 KDR VEGFA
14 11.1 FGF2 KDR VEGFA
15 11.05 EDNRA EDNRB
16 10.98 FGF2 VEGFA
17 10.96 FGF2 KDR VEGFA
18 10.85 FGF2 KDR VEGFA
19
Show member pathways
10.68 KDR VEGFA
20 10.18 FGF2 KDR VEGFA

GO Terms for Radiation Proctitis

Cellular components related to Radiation Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 AOC1 FGF2 KDR LTF TF TNF
2 cell surface GO:0009986 9.56 LTF TF TNF VEGFA
3 extracellular space GO:0005615 9.5 AOC1 FGF2 LTF PECAM1 TF TNF
4 membrane raft GO:0045121 8.92 EDNRB KDR PECAM1 TNF

Biological processes related to Radiation Proctitis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.91 EDNRB KDR LTF VEGFA
2 positive regulation of cell proliferation GO:0008284 9.9 EDNRB FGF2 KDR VEGFA
3 angiogenesis GO:0001525 9.76 FGF2 KDR PECAM1 VEGFA
4 positive regulation of angiogenesis GO:0045766 9.73 FGF2 KDR VEGFA
5 platelet degranulation GO:0002576 9.7 PECAM1 TF VEGFA
6 extracellular matrix organization GO:0030198 9.67 FGF2 KDR PECAM1 TNF
7 positive regulation of endothelial cell proliferation GO:0001938 9.65 FGF2 KDR VEGFA
8 protein kinase B signaling GO:0043491 9.62 KDR TNF
9 iron ion homeostasis GO:0055072 9.62 LTF TF
10 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.61 KDR VEGFA
11 positive regulation of MAP kinase activity GO:0043406 9.61 FGF2 TNF VEGFA
12 branching involved in blood vessel morphogenesis GO:0001569 9.59 EDNRA VEGFA
13 positive regulation of sprouting angiogenesis GO:1903672 9.58 FGF2 VEGFA
14 positive regulation of focal adhesion assembly GO:0051894 9.58 KDR VEGFA
15 positive regulation of protein complex assembly GO:0031334 9.57 TNF VEGFA
16 positive regulation of protein phosphorylation GO:0001934 9.56 EDNRB KDR TNF VEGFA
17 vasoconstriction GO:0042310 9.55 EDNRA EDNRB
18 vascular endothelial growth factor signaling pathway GO:0038084 9.54 KDR VEGFA
19 enteric nervous system development GO:0048484 9.51 EDNRA EDNRB
20 positive regulation of blood vessel endothelial cell migration GO:0043536 9.5 FGF2 KDR VEGFA
21 positive regulation of positive chemotaxis GO:0050927 9.49 KDR VEGFA
22 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.4 KDR VEGFA
23 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.33 FGF2 KDR VEGFA
24 endothelin receptor signaling pathway GO:0086100 8.96 EDNRA EDNRB
25 cell migration involved in sprouting angiogenesis GO:0002042 8.8 FGF2 KDR VEGFA

Molecular functions related to Radiation Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 FGF2 TNF VEGFA
2 chemoattractant activity GO:0042056 9.26 FGF2 VEGFA
3 heparin binding GO:0008201 9.26 AOC1 FGF2 LTF VEGFA
4 endothelin receptor activity GO:0004962 8.62 EDNRA EDNRB

Sources for Radiation Proctitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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