MCID: RDT013
MIFTS: 47

Radiation Proctitis

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Radiation Proctitis

MalaCards integrated aliases for Radiation Proctitis:

Name: Radiation Proctitis 58 70 32

Characteristics:

Orphanet epidemiological data:

58
radiation proctitis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare gastroenterological diseases


External Ids:

ICD10 32 K62.7
ICD10 via Orphanet 33 K62.7
UMLS via Orphanet 71 C0400827
Orphanet 58 ORPHA70475
UMLS 70 C0400827

Summaries for Radiation Proctitis

MalaCards based summary : Radiation Proctitis is related to proctitis and chronic ulcer of skin. An important gene associated with Radiation Proctitis is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. The drugs Sucralfate and Antacids have been mentioned in the context of this disorder. Affiliated tissues include prostate, colon and cervix, and related phenotypes are hematochezia and abnormality of connective tissue

Wikipedia : 73 Radiation proctitis or radiation proctopathy is condition characterized by damage to the rectum after... more...

Related Diseases for Radiation Proctitis

Diseases related to Radiation Proctitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 proctitis 29.6 VEGFA TNF PECAM1 LTF KDR HEY2
2 chronic ulcer of skin 29.5 VEGFA TNF FGF2
3 iron deficiency anemia 29.5 TNF TF LTF
4 telangiectasis 10.4
5 pulmonary arterial hypertension associated with connective tissue disease 10.3 EDNRB EDNRA
6 rectum cancer 10.3
7 bullous impetigo 10.3 EDNRB EDNRA
8 acquired color blindness 10.3 EDNRB EDNRA
9 perinephritis 10.3 EDNRB EDNRA
10 hemorrhoid 10.3
11 transient refractive change 10.3 EDNRB EDNRA
12 ritter's disease 10.2 EDNRB EDNRA
13 pulmonary vein stenosis 10.2 PECAM1 KDR
14 breast angiosarcoma 10.2 PECAM1 KDR
15 kaposiform hemangioendothelioma 10.2 PECAM1 KDR
16 prostate angiosarcoma 10.2 VEGFA PECAM1
17 prostate cancer 10.2
18 suppressor of tumorigenicity 3 10.2
19 endometrial cancer 10.2
20 diarrhea 10.2
21 central nervous system hemangioma 10.2 VEGFA PECAM1
22 raynaud disease 10.2 EDNRB EDNRA
23 pediatric angiosarcoma 10.2 VEGFA PECAM1
24 retroperitoneal hemangiopericytoma 10.2 VEGFA PECAM1
25 bacillary angiomatosis 10.2 VEGFA PECAM1
26 glomeruloid hemangioma 10.2 VEGFA PECAM1
27 gorham's disease 10.2 VEGFA PECAM1
28 bartonellosis 10.2 VEGFA PECAM1
29 vaginal cancer 10.2
30 gastric antral vascular ectasia 10.2
31 waardenburg syndrome, type 4b 10.1 EDNRB EDNRA
32 epithelioid hemangioendothelioma 10.1 VEGFA KDR
33 primary cutaneous b-cell lymphoma 10.1 VEGFA KDR
34 cervical cancer 10.1
35 barrett esophagus 10.1
36 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.1
37 deficiency anemia 10.1
38 mucositis 10.1
39 cystitis 10.1
40 rectum adenocarcinoma 10.1
41 iron metabolism disease 10.1
42 radiation cystitis 10.1
43 cavernous hemangioma 10.0 PECAM1 KDR FGF2
44 angiodysplasia 10.0 VEGFA FGF2
45 lung non-squamous non-small cell carcinoma 10.0 VEGFA KDR
46 superficial siderosis of the central nervous system 10.0 TF LTF
47 superficial siderosis 10.0 TF LTF
48 juvenile nasopharyngeal angiofibroma 10.0 VEGFA PECAM1 FGF2
49 lymphangiosarcoma 10.0 TNF PECAM1
50 gastroesophageal junction adenocarcinoma 10.0 VEGFA KDR

Graphical network of the top 20 diseases related to Radiation Proctitis:



Diseases related to Radiation Proctitis

Symptoms & Phenotypes for Radiation Proctitis

Human phenotypes related to Radiation Proctitis:

58 31 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hematochezia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002573
2 abnormality of connective tissue 58 31 hallmark (90%) Very frequent (99-80%) HP:0003549
3 rectal fistula 58 31 hallmark (90%) Very frequent (99-80%) HP:0100590
4 abnormality of gastrointestinal vasculature 58 31 hallmark (90%) Very frequent (99-80%) HP:0004296
5 rectal abscess 58 31 hallmark (90%) Very frequent (99-80%) HP:0005224
6 sepsis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100806
7 intestinal obstruction 58 31 occasional (7.5%) Occasional (29-5%) HP:0005214
8 arteritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012089
9 tenesmus 58 31 occasional (7.5%) Occasional (29-5%) HP:0012702
10 abnormality of the vasculature 58 Very frequent (99-80%)
11 diarrhea 58 Occasional (29-5%)
12 abnormality of the rectum 58 Very frequent (99-80%)
13 abnormal vascular morphology 58 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Radiation Proctitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with carboplatin GR00207-A-11 8.92 ENTPD1
2 Decreased viability with carboplatin GR00207-A-7 8.92 EDNRA ENTPD1
3 Decreased viability with carboplatin GR00207-A-9 8.92 EDNRA

MGI Mouse Phenotypes related to Radiation Proctitis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.26 AOC1 EDNRA EDNRB ENTPD1 FGF2 HEY2
2 homeostasis/metabolism MP:0005376 10.23 AOC1 EDNRA EDNRB ENTPD1 FGF2 HEY2
3 behavior/neurological MP:0005386 10.19 AOC1 EDNRA EDNRB ENTPD1 FGF2 KDR
4 hematopoietic system MP:0005397 10.18 EDNRA EDNRB ENTPD1 FGF2 KDR LTF
5 immune system MP:0005387 10.09 EDNRA EDNRB ENTPD1 KDR LTF PECAM1
6 embryo MP:0005380 10.04 EDNRA EDNRB HEY2 KDR TF TNF
7 muscle MP:0005369 10.02 EDNRA EDNRB ENTPD1 FGF2 HEY2 KDR
8 craniofacial MP:0005382 9.99 EDNRA EDNRB HEY2 KDR TNF VEGFA
9 liver/biliary system MP:0005370 9.95 ENTPD1 HEY2 KDR LTF PECAM1 TNF
10 nervous system MP:0003631 9.91 EDNRA EDNRB ENTPD1 FGF2 HEY2 KDR
11 respiratory system MP:0005388 9.76 EDNRA EDNRB ENTPD1 HEY2 KDR PECAM1
12 neoplasm MP:0002006 9.72 EDNRB FGF2 LTF TNF VEGFA
13 skeleton MP:0005390 9.56 EDNRA EDNRB FGF2 KDR PECAM1 TF
14 vision/eye MP:0005391 9.28 AOC1 EDNRA EDNRB ENTPD1 FGF2 KDR

Drugs & Therapeutics for Radiation Proctitis

Drugs for Radiation Proctitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sucralfate Approved Phase 4 54182-58-0
2 Antacids Phase 4
3 Gastrointestinal Agents Phase 4
4 Anti-Ulcer Agents Phase 4
5 Acidophilus Phase 2, Phase 3
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
7
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
8
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
9 Orange Approved Phase 2
10
Bisacodyl Approved Phase 2 603-50-9
11
tannic acid Approved Phase 2 1401-55-4
12
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
13
Thalidomide Approved, Investigational, Withdrawn Phase 2 50-35-1 5426
14
Budesonide Approved Phase 2 51333-22-3 63006 5281004
15 Cola Phase 2
16 Angiogenesis Inhibitors Phase 2
17 Immunosuppressive Agents Phase 2
18 Immunologic Factors Phase 2
19 Anti-Bacterial Agents Phase 2
20 Anti-Infective Agents Phase 2
21 Anti-Asthmatic Agents Phase 2
22 Respiratory System Agents Phase 2
23 glucocorticoids Phase 2
24 Hormones Phase 2
25 Hormone Antagonists Phase 2
26 Bronchodilator Agents Phase 2
27 Anti-Inflammatory Agents Phase 2
28 Anesthetics

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Argon Plasma Coagulation Plus Placebo or Oral Sucralfate for Chronic Radiation Proctopathy: a Randomized Placebo Controlled Trial Completed NCT01613534 Phase 4 Sucralfate;Placebo
2 A Single Center Pilot Study of CryoSpray Ablation(TM) to Determine Safety and Feasibility in Radiation Induced Proctitis (CSA LGI-2) Withdrawn NCT00756197 Phase 4
3 Efficacy of Symbiotic in the Reduction of Acute Radiation Proctitis Symptoms. A Randomized, Double-blind, Placebo-controlled Trial Completed NCT01901042 Phase 2, Phase 3
4 A Multicenter, Randomized, Double Blind Placebo Controlled Trial of Micronized Purified Flavonoid- Fraction (MPFF) in the Management of Radiation Proctitis Recruiting NCT04335617 Phase 3 MMPF (Micronized purified Flavonoid-Fraction)
5 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Unknown status NCT03302858 Phase 2
6 Comparison Between Two Different Parameters of Argon Plasma Coagulation in the Treatment of Chronic Radiation Proctitis: Historical Control Trial. Completed NCT02104271 Phase 2
7 Prospective, Open Clinical Trial of Thalidomide in the Treatment of Chronic Radiation Proctitis With Intractable Bleeding Not yet recruiting NCT04680195 Phase 2 Thalidomide
8 Randomised, Double-blind, Placebo-controlled, Multicentre, Comparative Phase II Pilot Study on the Efficacy and Tolerability of an 8-week Rectal Treatment With 2 mg Budesonide or Placebo for the Prevention of Acute Radiation Proctitis Terminated NCT00828230 Phase 2 budesonide;Placebo foam
9 Randomized Trial of Argon Plasma Coagulation Versus Argon Plasma Coagulation and Hemospray in the Therapy of Radiation Proctitis Unknown status NCT02233933
10 Treatment of Hemorrhagic Radiation Proctitis Using the Halo System Completed NCT01103492
11 Transverse Colostomy for Refractory Hemorrhagic Chronic Radiation Proctitis With Moderate to Severe Anemia: a Prospective Cohort Study Recruiting NCT03397901

Search NIH Clinical Center for Radiation Proctitis

Genetic Tests for Radiation Proctitis

Anatomical Context for Radiation Proctitis

MalaCards organs/tissues related to Radiation Proctitis:

40
Prostate, Colon, Cervix, Endothelial, Whole Blood, Lymph Node, T Cells

Publications for Radiation Proctitis

Articles related to Radiation Proctitis:

(show top 50) (show all 459)
# Title Authors PMID Year
1
Letter to the editor on: F. Campostrini et al. Association between acute histopathological changes of rectal walls and late radiation proctitis following radiotherapy for prostate cancer. 61
33296001 2021
2
The value of Metronidazole in the management of acute radiation proctitis. 61
33577737 2021
3
Management of Long-Term Toxicity From Pelvic Radiation Therapy. 61
33793314 2021
4
It's All the RAVE: Time to Give up on the "Chronic Radiation Proctitis" Misnomer. 61
33096102 2021
5
Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial. 61
33616843 2021
6
Endorectal formalin instillation or argon plasma coagulation for hemorrhagic radiation proctopathy therapy: a prospective and randomized clinical trial. 61
33220297 2020
7
Diverting colostomy is an effective procedure for ulcerative chronic radiation proctitis patients after pelvic malignancy radiation. 61
33143666 2020
8
A Randomized Controlled Trial of Novel Treatment for Hemorrhagic Radiation Proctitis. 61
33112550 2020
9
Multi-donor multi-course faecal microbiota transplantation relieves the symptoms of chronic hemorrhagic radiation proctitis: A case report. 61
32991434 2020
10
An observational trial to establish the effect of hyperbaric oxygen treatment on pelvic late radiation tissue injury due to radiotherapy. 61
32957127 2020
11
A huge rectal ulcer due to argon plasma coagulation in a patient with radiation proctitis. 61
32686433 2020
12
Association between acute histopathological changes of rectal walls and late radiation proctitis following radiotherapy for prostate cancer. 61
32166451 2020
13
The efficacy and dosimetry analysis of CT-guided 125I seed implantation assisted with 3D-printing non-co-planar template in locally recurrent rectal cancer. 61
32711542 2020
14
Quantitative CT measurement of left colonic and pelvic mesenteric adipose volume in radiation proctitis. 61
32793726 2020
15
Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF-κB and VEGF. 61
32638843 2020
16
Rubber Band Ligation of Hemorrhoids is often a Necessary Complement in the Management of Hemorrhagic Radiation Proctitis. 61
30632450 2020
17
Rates of rectal toxicity in patients treated with high dose rate brachytherapy as monotherapy compared to dose-escalated external beam radiation therapy for localized prostate cancer. 61
32276193 2020
18
Evaluation and Management of Chronic Radiation Proctitis. 61
32032142 2020
19
Pravastatin Alleviates Radiation Proctitis by Regulating Thrombomodulin in Irradiated Endothelial Cells. 61
32164317 2020
20
Expert Commentary on the Evaluation and Management of Radiation Proctitis. 61
32032143 2020
21
Linked color imaging improves visibility of ectatic vessels in radiation proctitis during argon plasma coagulation. 61
31917490 2020
22
Effect of interval between preoperative radiotherapy and surgery on clinical outcome and radiation proctitis in rectal cancer from FOWARC trial. 61
31828956 2020
23
Selection Criteria and Clinical Outcomes of Patients With Asymmetrical Cervical Cancer Treated With Various High-dose-rate Brachytherapy Techniques. 61
32014945 2020
24
Efficacy of sucralfate ointment in the prevention of acute proctitis in cancer patients: A randomized controlled clinical trial. 61
33680383 2020
25
Treatment and outcomes of patients with chronic radiation proctitis. A single-center experience and review of the literature. 61
33554948 2020
26
Efficacy of Synbiotics to Reduce Symptoms and Rectal Inflammatory Response in Acute Radiation Proctitis: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial. 61
31364875 2020
27
Technical challenges and potential solutions for rectal and sigmoid tumours following previous radiation for prostate malignancy: A case series. 61
32759040 2020
28
Utilization of Iodinated SpaceOAR Vue™ During Robotic Prostate Stereotactic Body Radiation Therapy (SBRT) to Identify the Rectal-Prostate Interface and Spare the Rectum: A Case Report. 61
33489918 2020
29
Short and long term response to argon plasma therapy for hemorrhagic radiation proctitis. 61
31595754 2019
30
Clinical Anastomotic Leakage After Rectal Cancer Resection Can Be Predicted by Pelvic Anatomic Features on Preoperative MRI Scans: A Secondary Analysis of a Randomized Controlled Trial. 61
31567929 2019
31
A phase 2 randomized controlled trial of oral resistant starch supplements in the prevention of acute radiation proctitis in patients treated for cervical cancer. 61
31898677 2019
32
Efficacy and safety of radiofrequency ablation for treatment of chronic radiation proctitis: A systematic review and meta-analysis. 61
31111527 2019
33
Rectal wall dose-volume effect of pre- or post KUSHEN Ningjiaos relationship with 3D brachytherapy in cervical cancer patients. 61
31429773 2019
34
Gastrointestinal: Radiation proctitis: Or is it something else? 61
30693563 2019
35
Management of radiation-induced proctitis. 61
31463226 2019
36
Saponins regulate intestinal inflammation in colon cancer and IBD. 61
30959159 2019
37
The use of aloe vera in cancer radiation: An updated comprehensive review. 61
31003648 2019
38
Argon plasma coagulation is an effective treatment for chronic radiation proctitis in gynaecological malignancy: an observational study. 61
30585689 2019
39
Efficacy and complications of argon plasma coagulation for hemorrhagic chronic radiation proctitis. 61
30983821 2019
40
Management of Severe Radiation Proctitis with Radiofrequency Ablation. 61
30976619 2019
41
Comparison of relative and absolute rectal dose-volume parameters and clinical correlation with acute and late radiation proctitis in prostate cancer patients. 61
30191285 2019
42
Four percent formalin application for the management of radiation proctitis in carcinoma cervix patients: An effective, safe, and economical practice. 61
30880761 2019
43
Application of 4% formaldehyde under electronic colonoscope as a minimally invasive treatment of chronic hemorrhagic radiation proctitis. 61
31534597 2019
44
What is the impact of diabetes mellitus on radiation induced acute proctitis after radical radiotherapy for adenocarcinoma prostate? A prospective longitudinal study. 61
30623118 2019
45
[Chinese consensus on diagnosis and treatment of radiation proctitis (2018)]. 61
30588581 2018
46
The role of endoscopic evaluation for radiation proctitis in patients receiving intermediate-dose postoperative radiotherapy for rectal cancer. 61
30239826 2018
47
Hyaluronic acid for treatment of the radiation therapy side effects: a systematic review. 61
30468506 2018
48
Outcomes of Asian patients with localized prostate cancer treated with combined intensity modulated radiation therapy (IMRT) and high dose rate (HDR) brachytherapy: A single institution experience. 61
29171166 2018
49
The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Chronic Radiation Proctitis. 61
30192320 2018
50
Long extensive radiation proctitis treated with rectal band ligation (with video). 61
29884558 2018

Variations for Radiation Proctitis

Expression for Radiation Proctitis

Search GEO for disease gene expression data for Radiation Proctitis.

Pathways for Radiation Proctitis

GO Terms for Radiation Proctitis

Cellular components related to Radiation Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.02 TNF TF PECAM1 LTF KDR ENTPD1
2 extracellular region GO:0005576 9.87 VEGFA TNF TF LTF KDR FGF2
3 integral component of plasma membrane GO:0005887 9.63 TNF PECAM1 KDR ENTPD1 EDNRB EDNRA
4 extracellular space GO:0005615 9.5 VEGFA TNF TF PECAM1 LTF FGF2
5 recycling endosome GO:0055037 9.43 TNF TF LTF
6 membrane raft GO:0045121 8.92 TNF PECAM1 KDR EDNRB

Biological processes related to Radiation Proctitis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.95 VEGFA TNF HEY2 FGF2
2 extracellular matrix organization GO:0030198 9.86 TNF PECAM1 KDR FGF2
3 positive regulation of protein kinase B signaling GO:0051897 9.83 VEGFA TNF FGF2
4 positive regulation of angiogenesis GO:0045766 9.81 VEGFA KDR FGF2
5 platelet degranulation GO:0002576 9.79 VEGFA TF PECAM1
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.78 VEGFA TNF KDR FGF2
7 positive regulation of MAPK cascade GO:0043410 9.77 VEGFA KDR FGF2
8 positive regulation of endothelial cell proliferation GO:0001938 9.74 VEGFA KDR FGF2
9 positive regulation of endothelial cell migration GO:0010595 9.72 VEGFA KDR FGF2
10 vasculogenesis GO:0001570 9.71 VEGFA KDR HEY2
11 positive regulation of MAP kinase activity GO:0043406 9.7 VEGFA TNF FGF2
12 negative regulation of gene expression GO:0010629 9.65 VEGFA TNF KDR HEY2 FGF2
13 positive regulation of focal adhesion assembly GO:0051894 9.64 VEGFA KDR
14 iron ion transport GO:0006826 9.63 TF LTF
15 vasoconstriction GO:0042310 9.63 EDNRB EDNRA
16 vascular endothelial growth factor signaling pathway GO:0038084 9.62 VEGFA KDR
17 positive regulation of DNA biosynthetic process GO:2000573 9.61 VEGFA FGF2
18 enteric nervous system development GO:0048484 9.61 EDNRB EDNRA
19 positive regulation of blood vessel endothelial cell migration GO:0043536 9.61 VEGFA KDR FGF2
20 positive regulation of positive chemotaxis GO:0050927 9.59 VEGFA KDR
21 vascular wound healing GO:0061042 9.58 VEGFA KDR
22 endothelin receptor signaling pathway GO:0086100 9.58 EDNRB EDNRA
23 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.54 VEGFA KDR FGF2
24 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.51 VEGFA KDR
25 branching involved in blood vessel morphogenesis GO:0001569 9.5 VEGFA KDR EDNRA
26 vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 9.49 VEGFA KDR
27 positive regulation of epithelial tube formation GO:1905278 9.46 VEGFA FGF2
28 cardiac vascular smooth muscle cell development GO:0060948 9.4 VEGFA HEY2
29 cell migration involved in sprouting angiogenesis GO:0002042 9.33 VEGFA KDR FGF2
30 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.26 VEGFA TNF KDR FGF2
31 positive regulation of protein phosphorylation GO:0001934 9.1 VEGFA TNF PECAM1 KDR FGF2 EDNRB

Molecular functions related to Radiation Proctitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.26 VEGFA LTF FGF2 AOC1
2 endothelin receptor activity GO:0004962 8.62 EDNRB EDNRA

Sources for Radiation Proctitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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