MCID: RDC002
MIFTS: 51

Radiculopathy

Categories: Bone diseases, Muscle diseases, Neuronal diseases

Aliases & Classifications for Radiculopathy

MalaCards integrated aliases for Radiculopathy:

Name: Radiculopathy 12 44 15 70 32
Pinched Nerve 12 53
Nerve Root Disorder 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4306
MeSH 44 D011843
SNOMED-CT 67 394640000
ICD10 32 M54.1
UMLS 70 C0700594 C1527351

Summaries for Radiculopathy

NINDS : 53 The term "pinched nerve" is a colloquial term and not a true medical term.  It is used to describe one type of damage or injury to a nerve or set of nerves. The injury may result from compression, constriction, or stretching. Symptoms include numbness, "pins and needles" or burning sensations, and pain radiating outward from the injured area. One of the most common examples of a single compressed nerve is the feeling of having a foot or hand "fall asleep." A "pinched nerve" frequently is associated with pain in the neck or lower back.  This type of pain can be caused by inflammation or pressure on the nerve root as it exits the spine.  If the pain is severe or lasts a long time, you may need to have further evaluation from your physician.  Several problems can lead to similar symptoms of numbness, pain, and tingling in the hands or feet but without pain in the neck or back.  These can include peripheral neuropathy, carpal tunnel syndrome, and tennis elbow. The extent of such injuries may vary from minor, temporary damage to a more permanent condition. Early diagnosis is important to prevent further damage or complications. Pinched nerve is a common cause of on-the-job injury.

MalaCards based summary : Radiculopathy, also known as pinched nerve, is related to whiplash and exanthem, and has symptoms including neuralgia An important gene associated with Radiculopathy is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Meloxicam and Pregabalin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and dorsal root ganglion, and related phenotype is immune system.

Disease Ontology : 12 A peripheral nervous system disease that is characterized by the pinching of a nerve root in the spine and has symptoms of pain, weakness, numbness and tingling.

Wikipedia : 73 Radiculopathy, also commonly referred to as pinched nerve, refers to a set of conditions in which one or... more...

Related Diseases for Radiculopathy

Diseases related to Radiculopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 804)
# Related Disease Score Top Affiliating Genes
1 whiplash 30.6 CCL5 CCL4 CCL3
2 exanthem 30.6 IL6 IL10 IFNA1 CXCL8
3 spondylitis 30.5 IL6 IL17A IL10
4 fibromyalgia 30.5 IL6 IL10 CXCL8 CCL2
5 myositis 30.4 IL6 IL1A IL17A IFNA1 CXCL8
6 spondylosis 30.4 LAPTM4A BMP2 ACAN
7 carpal tunnel syndrome 30.4 TAC1 IL6 CCL2
8 chickenpox 30.4 IL6 IL10 IFNA1
9 cytokine deficiency 30.4 IL5 IL13
10 spondyloarthropathy 1 30.2 IL6 IL1R1 IL17A
11 myelitis 30.2 IL6 IL17A IL10 CXCL8
12 aortic aneurysm, familial abdominal, 1 30.1 IL6 IL10 CXCL8 CCL2
13 lyme disease 30.1 IL6 IL17A IFNA1
14 endometriosis 30.1 IL6 CXCL8 CCL5 CCL2
15 peripheral nervous system disease 30.1 TAC1 IL6 IL17A IL10 CXCL8 CCL2
16 polyradiculoneuropathy 30.1 IL17A IL10 CCL5 CCL4
17 chronic inflammatory demyelinating polyradiculoneuropathy 30.1 IL17A IL10 CCL5 CCL4
18 cryptococcosis 30.0 IL17A IL13 IL10
19 neuromyelitis optica 30.0 IL6 IL5 IL17A IFNA1
20 osteoarthritis 29.9 IL6 IL1A IL17A CXCL8 ACAN
21 infective endocarditis 29.9 IL6 IL17A CCL4
22 scrub typhus 29.9 IL17A IL15 IL10
23 cysticercosis 29.9 IL6 IL5 IL10
24 spondylolisthesis 29.9 TAC1 BMP2 ACAN
25 spondyloarthropathy 29.9 IL6 IL17A IL10 CCL2
26 temporal arteritis 29.9 IL6 IL17A CCL5 CCL2
27 eosinophilic meningitis 29.9 IL5 IL13 IL10
28 cerebral palsy 29.9 IL6 IL15 IL13 IL10 CXCL8
29 pulmonary fibrosis 29.9 IL13 CXCL8 CCL3 CCL2
30 arachnoiditis 29.8 TAC1 IL1A
31 bacterial meningitis 29.8 IL6 IL17A IL10 CXCL8 CCL4 CCL2
32 cellulitis 29.8 IL6 IL5 IL1R1
33 bronchopneumonia 29.8 IL6 IL17A IL10 CXCL8 CCL3
34 hypereosinophilic syndrome 29.7 IL5 IL13 IFNA1 CXCL8 CCL5
35 burning mouth syndrome 29.7 TAC1 IL6 CXCL8
36 bursitis 29.7 TAC1 LAPTM4A IL6
37 pain agnosia 29.6 TAC1 PENK IL6
38 shoulder impingement syndrome 29.6 TAC1 LAPTM4A
39 aseptic meningitis 29.6 IL1R1 IL1A IL10 CXCL8 CCL3
40 endocarditis 29.6 IL6 IL1A IL17A IL10 CXCL8 CCL4
41 sarcoidosis 1 29.6 IL1A IL15 IL13 CCL5 CCL4 CCL3
42 meningoencephalitis 29.5 TAC1 IL6 IL10 CCL5
43 mycobacterium tuberculosis 1 29.5 IL7 IL17A IL10 CCL4 CCL3
44 leukemia, acute myeloid 29.4 IL7 IL6 IL15 IL10 IFNA1 CXCL8
45 epicondylitis 29.4 TAC1 LAPTM4A ACAN
46 myofascial pain syndrome 29.3 TAC1 LAPTM4A
47 uveitis 29.1 IL6 IL1R1 IL1A IL17A IL10 CXCL8
48 osteomyelitis 29.1 IL6 IL1A IL10 CXCL8 CCL2 BMP2
49 demyelinating disease 29.1 IL6 IL17A IL10 IFNA1 CCL5 CCL4
50 migraine with or without aura 1 29.1 TAC1 LAPTM4A IL6 IL10

Graphical network of the top 20 diseases related to Radiculopathy:



Diseases related to Radiculopathy

Symptoms & Phenotypes for Radiculopathy

UMLS symptoms related to Radiculopathy:


neuralgia

MGI Mouse Phenotypes related to Radiculopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.4 BMP2 CCL2 CCL5 IL10 IL13 IL15

Drugs & Therapeutics for Radiculopathy

Drugs for Radiculopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 134)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
2
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
3
Ibuprofen Approved Phase 4 15687-27-1 3672
4
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
5
Eplerenone Approved Phase 4 107724-20-9 443872 150310
6
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
7
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
8
Acetaminophen Approved Phase 4 103-90-2 1983
9
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
10
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
11
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
12
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 11103-57-4 445354
13 Betamethasone Valerate Phase 4 2152-44-5
14 Betamethasone acetate phosphate Phase 4
15 Betamethasone benzoate Phase 4
16 Betamethasone sodium phosphate Phase 4
17 Betamethasone-17,21-dipropionate Phase 4
18 Anticonvulsants Phase 4
19 Cyclooxygenase 2 Inhibitors Phase 4
20
protease inhibitors Phase 4
21 HIV Protease Inhibitors Phase 4
22 retinol Phase 4
23 Retinol palmitate Phase 4
24 Dexamethasone 21-phosphate Phase 4
25 Psychotropic Drugs Phase 4
26 Analgesics Phase 4
27 Anti-Anxiety Agents Phase 4
28 Analgesics, Non-Narcotic Phase 4
29 Antirheumatic Agents Phase 4
30 Cyclooxygenase Inhibitors Phase 4
31 Anti-Inflammatory Agents, Non-Steroidal Phase 4
32 Vasodilator Agents Phase 4
33 Radiation-Protective Agents Phase 4
34 Antioxidants Phase 4
35 Phosphodiesterase Inhibitors Phase 4
36 Antipyretics Phase 4
37 Platelet Aggregation Inhibitors Phase 4
38 calcium channel blockers Phase 4
39 Calcium, Dietary Phase 4
40 Antihypertensive Agents Phase 4
41 Mineralocorticoids Phase 4
42 diuretics Phase 4
43 Mineralocorticoid Receptor Antagonists Phase 4
44 Anesthetics Phase 4
45 Anesthetics, Local Phase 4
46 Anti-Arrhythmia Agents Phase 4
47 Sodium Channel Blockers Phase 4
48 Triamcinolone diacetate Phase 4
49 Immunosuppressive Agents Phase 4
50 triamcinolone acetonide Phase 4

Interventional clinical trials:

(show top 50) (show all 231)
# Name Status NCT ID Phase Drugs
1 A Post-marketing Evaluation of a Compound Traditional Chinese Herbal Medicine, Qishe Pill, on Cervical Radiculopathy Unknown status NCT01875562 Phase 4 Qishe Pill
2 A Prospective Randomized Trails for Primary Disc Herniation With Radiculopathy:Conservative Versus Aggressive Discectomy Unknown status NCT01204008 Phase 4
3 Transforaminal Epidural Steroid Injection in Conjunction With Pulsed Radiofrequency Treatment of the Lumbar Dorsal Root Ganglion for the Management of Chronic Lumbosacral Radicular Pain: a Randomized, Double-blind Trial Unknown status NCT02930057 Phase 4 Celestone;Control
4 Efficacy Study of Caudal Epidural Steroid Injections in Patients With Low Back Pain/Radiculopathy Completed NCT01407913 Phase 4
5 Comparison of the Efficacy of Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation of the Motor Cortex in Patients With Neuropathic Pain Due to Chronic Radiculopathy Completed NCT02030626 Phase 4
6 Arthroplasty Versus Fusion in Anterior Cervical Surgery: Prospective Study of the Impact on the Adjacent Level Completed NCT00554528 Phase 4
7 A Prospective Randomized Comparative Trial of Targeted Injection Via a Transforaminal Approach With Dexamethasone Versus an Epidural Catheter Via an Interlaminar Approach With Particulate Steroid for the Treatment of Cervical Radicular Pain Completed NCT03382821 Phase 4 Dexamethasone Sodium Phosphate 10 MG/ML;Lidocaine;Triamcinolone Acetonide 40mg/mL
8 Open Labelled Study of Pregabalin in the Treatment of Neuropathic Pain in Cervical Myeloradiculopathy (Pregabalin and Radicular Pain Study (PARPS)) Completed NCT01061697 Phase 4 Pregabalin
9 Single Blinded, Randomized Control Trial of High Frequency Stimulation in Subjects With Precision® Spinal Cord Stimulator System to Assess Efficacy and Preferability in Back and Extremity Pain Relief Completed NCT02265848 Phase 4
10 A Prospective Randomized Controlled Trial of Standardized C7-T1 Epidural Steroid Injections Versus Targeted Injection Via Cervical Epidural Catheter for the Treatment of Cervical Radicular Pain Completed NCT02095197 Phase 4 Triamcinolone 80mg
11 Efficacy of Pregabalin in Patients With Radicular Pain Completed NCT00908375 Phase 4 Pregabalin;Sugar Pill
12 Defining the Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy Recruiting NCT03801356 Phase 4 Selective Nerve Root Block
13 The Effectiveness of Cervical Transforaminal Epidural Steroid Injection for the Treatment of Cervical Radicular Pain: A Prospective Cohort Study. Recruiting NCT04544683 Phase 4 Cervical Transforaminal Epidural Injection with dexamethasone sodium phosphate
14 Do Cervical Interlaminar Epidural Steroid Injections With Low-dose Lidocaine Cause Transient Objective Upper Extremity Weakness? A Prospective Randomized Controlled Trial Recruiting NCT03127137 Phase 4 Experimental Group 1 triamcinolone and lidocaine;Experimental Group 2 triamcinolone and saline
15 Prospective Controlled Crossover Study of the Role of Pentoxifylline in the Management of Lumbar Radiculopathy Active, not recruiting NCT03060434 Phase 4 Pentoxifylline Oral Tablet;Ibuprofen
16 Epidural Steroid Injection With Supplemental Oral Eplerenone for Low Back Pain: A Prospective, Double Blind Randomized Trial Suspended NCT03418649 Phase 4 Eplerenone 50 Mg Tab;Placebo Oral Tablet
17 A Randomized Trial of CT-guided Perineural Injection With a Corticosteroid Plus a Long Acting Local Anesthetic Versus Standard Medical Management in Patients With Acute Lumbar Radiculopathy and a Corresponding Disc Herniation Terminated NCT01267825 Phase 4 CT-guided corticosteroid+ bupivicaine;Standard medical care
18 Single Center, Randomized PROspective Study Comparing Percutaneous HydroDiscectomy to Transforaminal Epidural Steroid Injections in the Treatment Of Radiculopathy Secondary to Lumbar Disc Herniation (PROPHESOR) Terminated NCT02414698 Phase 4 TESI
19 Do Cervical Interlaminar Epidural Steroid Injections With Low-dose Lidocaine Cause Transient Objective Upper Extremity Weakness? A Prospective Randomized Terminated NCT03382925 Phase 4 Lidocaine;Triamcinolone Acetonide;Normal saline
20 Combined Administration of Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Analgesia in Posterior Lumbar Spine Surgery - A Prospective Randomized Study Terminated NCT03514277 Phase 4 Exparel;Bupivacaine
21 Pragmatic Randomized Prospective Study of Cervical Interlaminar Epidural Injection of Particulate Steroid and Cervical Transforaminal Epidural Injection of Non-particulate Steroid in Patients With Cervical Radicular Pain Withdrawn NCT03165825 Phase 4 Transforaminal Epidural Steroid Injection with Dexamethasone;Interlaminar Epidural Steroid Injection with Betamethasone
22 A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy Completed NCT00733096 Phase 2, Phase 3 etanercept;methylprednisolone;normal saline
23 The Value of Mechanical Traction in the Treatment of Cervical Radiculopathy Completed NCT00979108 Phase 3
24 A Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Painful Lumbar Radiculopathy Completed NCT00120120 Phase 2, Phase 3 Lenalidomide (CC-5013)
25 A Randomized Placebo-Controlled Trial of the Efficacy and Safety of Pregabalin in the Treatment of Subjects With Neuropathic Pain Associated With Lumbo-Sacral Radiculopathy Completed NCT00159705 Phase 3 pregabalin
26 Open Randomised Comparative Study of the Efficacy and Safety of Neuromultivit (Solution for Injections, 2 ml) in Patients With Vertebrogenic Radiculopathy Completed NCT02508805 Phase 3 Neuromultivit;Voltaren;Sirdalud
27 Clinical Research on the Efficacy and Safety of Bosinji on LBP and Radiculopathy by HIVD of L-spine; A Multicenter, Randomized, Controlled, Clinical Trial Completed NCT03386149 Phase 3 Bosinji;Loxonine tab.
28 The Value of Traction in Treatment of Lumbar Radiculopathy. Completed NCT00942227 Phase 3
29 The Effectiveness of Selective Nerve Root Injections in Preventing the Need for Surgery in Patients With Lumbar Disc Herniations Completed NCT01073995 Phase 3 Kenalog and Sensorcaine
30 A Prospective, Randomized, Multi-Center, Post-Approval Clinical Trial Evaluating the Long-Term (7 Year) Safety and Effectiveness of the PCM® Cervical Disc Completed NCT01905930 Phase 3
31 A Prospective, Randomized, Controlled Clinical Investigation Comparing PCM® Cervical Disc Arthroplasty to Anterior Cervical Discectomy and Fusion: 2 Year Results From the US IDE Clinical Trial Completed NCT00578812 Phase 3
32 Immediate Pain Relieving Effects of Sinbaro-3 Pharmaco-acupuncture in Low Back Pain Patients; A Randomized Controlled Trial Completed NCT02196129 Phase 3 Sinbaro-3;Hwangryun
33 The Effectiveness of Manual Physical Therapy and Exercise for Mechanical Neck Disorders: A Randomized Controlled Trial Completed NCT00416117 Phase 2, Phase 3
34 A Single Site, Phase 2B, Randomized, Double-Blind, Study to Assess the Efficacy, Safety, and Tolerability of Twice Daily Oral ALLOD-2 vs. Placebo in the Treatment of Chronic Low Back Pain (ANODYNE-4) Completed NCT03201393 Phase 2, Phase 3 ALLOD-2 Capsules;Placebo Capsules
35 Physiotherapy Management of Lumbar Radicular Syndrome; Does Early Intervention Improve Outcomes? Completed NCT02618278 Phase 3
36 Corticosteroid Lumbar Epidural Analgesia for Radiculopathy (C.L.E.A.R.) Recruiting NCT03372161 Phase 3 SP-102;Placebo
37 A Prospective Registry Study Evaluating the Safety and Efficacy of Fibrin for Chronic Multi-level Discogenic Low Back Pain Recruiting NCT04621799 Phase 2, Phase 3 Fibrin sealant
38 A Prospective, Multicenter, Randomized, Double-Blinded, Sham-Control Study to Evaluate the Efficacy and Safety of Clonidine Micropellets for the Treatment of Pain Associated With Lumbosacral Radiculopathy in Adults Active, not recruiting NCT03727100 Phase 3
39 Study of Bone of Marrow Concentrate (BMC) Injection in Discs, Facets, Sacroiliac Joints, and Epidural Space for Chronic Lower Back Pain With and Without Radiculopathy Active, not recruiting NCT04559295 Phase 2, Phase 3
40 A Prospective, Multi-center, Pivotal Trial for INFUSE® Bone Graft With CAPSTONE® Spinal System and Posterior Supplemental Fixation to Treat 1- or 2-level Advanced Degenerative Disease of the Lumbosacral Spine For a TLIF Approach Terminated NCT01415908 Phase 3
41 Randomized, Prospective Study of Lumbar Transforaminal Epidural Corticosteroid Injection(s) Versus Defined Physical Therapy for the Treatment of Subacute Lumbar Radicular Pain Due to Disc Protrusion Terminated NCT01443819 Phase 3
42 Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Withdrawn NCT03327272 Phase 3 Methylprednisolone;Saline
43 REN-1654 in Sciatica: A Phase 2, Randomized, Double-Blind, Placebo Controlled, Multi-Center Study in Subjects With Pain Due to Lumbosacral Radiculopathy Unknown status NCT00107055 Phase 2 REN-1654
44 Effectiveness of a Compound Traditional Chinese Herbal Medicine, Qishe Pill, on Cervical Radiculopathy: a Randomized, Double-blind, Placebo-controlled, Multicentre Trial Unknown status NCT01274936 Phase 2 Qishe Pill;Qishe Placebo
45 Effect of Conservative Treatment With Cervical Collar in Patients With Cervical Radiculopathy and Radicular Pain. A Randomized Controlled Study Completed NCT00395798 Phase 2
46 A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Study Using a Bayesian Adaptive Design to Assess the Efficacy, Safety, Tolerability, and Serum Exposure of Multiple Doses of BG00010 (Neublastin) in Subjects With Painful Lumbar Radiculopathy Completed NCT01873404 Phase 2 BG00010;Placebo
47 A Randomised, Double Blind Study to Evaluate the Safety and Efficacy of the p38 Kinase Inhibitor, GW856553, in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy Completed NCT01110057 Phase 2 Placebo;GS856553
48 An Open-Label, Sequential, Dose Escalation Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy Completed NCT01917825 Phase 2 MDT-15
49 A Randomized, Double Blind, Cross-over Study to Evaluate the Safety and Efficacy of CNV1014802 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy Completed NCT01561027 Phase 2 CNV1014802;Placebo
50 A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy Completed NCT02935608 Phase 2 BIIB074;Placebo

Search NIH Clinical Center for Radiculopathy

Cochrane evidence based reviews: radiculopathy

Genetic Tests for Radiculopathy

Anatomical Context for Radiculopathy

MalaCards organs/tissues related to Radiculopathy:

40
Spinal Cord, Bone, Dorsal Root Ganglion, Myeloid, Cortex, Bone Marrow, Skin

Publications for Radiculopathy

Articles related to Radiculopathy:

(show top 50) (show all 6230)
# Title Authors PMID Year
1
Double crush syndrome: Epidemiology, diagnosis, and treatment results. 61
33130027 2021
2
"Anterior interosseous nerve syndrome (Kiloh Nevin Syndrome) revealing Gantzer muscle and simultaneous myasthenia gravis". 61
33664927 2021
3
Comparison of the efficacy and safety of acupuncture and acupotomy for patients with cervical spondylotic radiculopathy: A protocol for systematic review and meta-analysis. 61
33787607 2021
4
A rare case of parasagittal meningioma causing isolated foot drop: case report and review of the literature. 61
31786742 2021
5
Referral patterns for surgical consult in the management of patients with foot drop due to acute lumbar disc herniation: a survey study of physical therapists in the United States. 61
32530795 2021
6
Effect of Topical Steroid on Swallowing Following ACDF: Results of a Prospective Double-Blind Randomized Control Trial. 61
33273438 2021
7
Variation in global treatment for subaxial cervical spine isolated unilateral facet fractures. 61
33797624 2021
8
Marinacci anastomosis (reverse Martin-Gruber anastomosis): A case report. 61
33787589 2021
9
The Outcome of Epidural Injections in Lumbar Radiculopathy Is Not Dependent on the Presence of Disc Herniation on Magnetic Resonance Imaging: Assessment of Short-Term and Long-Term Efficacy. 61
33497827 2021
10
Pros and Cons of Resecting the PLL for Cervical Radiculopathy. 61
31917717 2021
11
Excursion of the median nerve during a contra-lateral cervical lateral glide movement in people with and without cervical radiculopathy. 61
33618231 2021
12
Intraoperative Neuromonitoring Use Patterns in Degenerative, Nondeformity Cervical Spine Surgery: A Survey of the Cervical Spine Research Society. 61
32991365 2021
13
Revision Surgery for a Failed Artificial Disc. 61
33635014 2021
14
ACDF plus Uncovertebrectomy versus ACDF alone for the Treatment of Cervical Spondylotic Radiculopathy: Minimum 5-Year Follow-Up. 61
33386028 2021
15
Public interest in musculoskeletal symptoms and disorders during the COVID-19 pandemic : Infodemiology study. 61
33779835 2021
16
Population Pharmacokinetics of Vixotrigine in Healthy Volunteers and Subjects with Trigeminal Neuralgia, Painful Lumbosacral Radiculopathy and Erythromelalgia. 61
33782834 2021
17
Four-level Anterior Cervical Discectomy and Fusions: Results Following Multilevel Cervical Fusion With a Minimum 1-Year Follow-up. 61
33769972 2021
18
Differential Diagnosis of Facet Joint Disorders. 61
33481690 2021
19
Quantitative analysis of myokymic discharges in radiation versus nonradiation cases. 61
33675544 2021
20
Management of Degenerative Spondylolisthesis: Development of Appropriate Use Criteria. 61
33689838 2021
21
MIS-TLIF versus O-TLIF for single-level degenerative stenosis: study protocol for randomised controlled trial. 61
33674366 2021
22
Extra-laminar microscopic-assisted percutaneous nucleotomy (EL-MAPN) for the treatment of foraminal lumbar disc prolapse, a modified minimally invasive approach. 61
33677658 2021
23
Radicular arm pain. 61
33792377 2021
24
Percutaneous discectomy under CT and fluoroscopy guidance: an international multicentric study. 61
33783556 2021
25
Validation of the Questionnaire for Symptom Assessment in Pain disorders for Back pain patients (Q-SAP). 61
33131154 2021
26
Factors Associated With Progression to Surgical Intervention for Lumbar Disc Herniation in the Military Health System. 61
33181775 2021
27
The effects of age, pathology, and fusion on cervical neural foramen area. 61
32167190 2021
28
An Unrecognized Ligament and its Ossification in the Craniocervical Junction: Prevalence, Patient Characteristics, and Anatomic Evidence. 61
33739308 2021
29
Neurolymphomatosis: a single-center experience of neuromuscular manifestations, treatments, and outcomes. 61
33098033 2021
30
Timing of evidence-based non-surgical interventions as part of multimodal treatment guidelines for the management of cervical radiculopathy: a Delphi study protocol. 61
33727266 2021
31
Acute Cervical Radiculopathy Outcomes: Soft Disc Herniations vs Osteophytes. 61
33225358 2021
32
Transforaminal Endoscopic Surgical Treatment for Post-Laminectomy Lumbar Radiculopathy: Case Series. 61
33746102 2021
33
Diagnostic usefulness of denervation edema in the multifidus muscles using 3-Tesla magnetic resonance imaging in cervical radiculopathy. 61
33314190 2021
34
Simplified Universal Grading of Lumbar Spine MRI Degenerative Findings: Inter-reader agreement of non-radiologist spine experts. 61
33713135 2021
35
Effectiveness of Mechanical Traction for Lumbar Radiculopathy: A Systematic Review and Meta-Analysis. 61
33382419 2021
36
Vertical traction for lumbar radiculopathy: a systematic review. 61
33715638 2021
37
Jingshu Keli for treating cervical spondylotic radiculopathy: The first multicenter, randomized, controlled clinical trial. 61
33376673 2021
38
Cost analysis of primary single level lumbar discectomies using the Value Driven Outcomes database in a large academic center. 61
33757873 2021
39
Surgical Techniques Ensuring Success in Posterior Endoscopic Cervical Foraminotomy and Discectomy at C6-7 in Patients with Prominent Shoulders and Short Necks. 61
33656743 2021
40
Validation of the Nepali versions of the Neck Disability Index and the Numerical Rating Scale for Neck Pain. 61
33181772 2021
41
Urdu version of Oswestry disability index; a reliability and validity study. 61
33781267 2021
42
A New Solution to an Old Problem: Ultra-Sound Guided Cervical Retro-Laminar Injection for Acute Cervical Radicular Pain. Prospective Clinical Pilot Study and Cadaveric Study. 61
33660679 2021
43
Transforaminal Endoscopic Surgical Treatment for Posterior Migration of Polyetheretherketone Transforaminal Lumbar Interbody Fusion Cage: Case Series. 61
33359521 2021
44
Neurological and electroneurography findings in patients with systemic sclerosis and symptoms of neuropathic pain in extremities. 61
30465254 2021
45
Prolonged median distal sensory nerve action potential duration in carpal tunnel syndrome. 61
33533066 2021
46
Sprengel Deformity with Omovertebral Bone Encroaching the Spinal Canal Causing Progressive Cervical Myelopathy: A Technical Case Report. 61
33220477 2021
47
Efficacy and toxicity of re-irradiation spine stereotactic body radiotherapy with respect to irradiation dose history. 61
33020807 2021
48
Three region spinal decompression in the same session: a case report. 61
33629635 2021
49
Compressive cervicothoracic pseudomeningocele as a rare manifestation of idiopathic intrathecal hypotension after past trauma: a review. 61
33620574 2021
50
Early Catastrophic Failure of Cervical Disc Arthroplasty: A Case Report. 61
33577187 2021

Variations for Radiculopathy

Expression for Radiculopathy

Search GEO for disease gene expression data for Radiculopathy.

Pathways for Radiculopathy

Pathways related to Radiculopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 IL7 IL6 IL5 IL1R1 IL1A IL17A
2
Show member pathways
13.9 PENK IL7 IL6 IL5 IL1R1 IL1A
3
Show member pathways
13.77 IL7 IL6 IL5 IL1R1 IL1A IL17A
4
Show member pathways
13.42 IL7 IL6 IL5 IL1R1 IL1A IL17A
5
Show member pathways
13.26 IL6 IL10 IFNA1 CXCL8 CCL5 CCL4
6
Show member pathways
13.23 PENK IL7 IL6 IL5 IL1R1 IL1A
7
Show member pathways
13.02 IL6 IL1R1 IFNA1 CXCL8 CCL5 CCL4
8
Show member pathways
13.01 PENK IL7 IL6 IL5 IL1R1 IL1A
9
Show member pathways
12.95 IL6 IL5 IL1A IL17A IL15 IL13
10 12.93 IL7 IL6 IL5 IL15 IL13 IFNA1
11
Show member pathways
12.87 IL6 IL1A IFNA1 CXCL8 CCL5 CCL2
12
Show member pathways
12.79 PENK IL7 IL6 IL5 IL1R1 IL1A
13
Show member pathways
12.74 IL6 IL1R1 IL1A IFNA1 CXCL8
14
Show member pathways
12.73 PENK IL6 IL1R1 IL1A BMP2
15
Show member pathways
12.69 IL6 IL5 IL1R1 IL1A IL17A IL13
16
Show member pathways
12.64 IL6 IL5 IL1A IL17A IL10
17 12.61 IL17A IL10 IFNA1 CCL5 CCL2
18
Show member pathways
12.53 IL7 IL6 IL5 IL15 IL13 IL10
19
Show member pathways
12.45 IL6 IL10 CXCL8 CCL5 CCL4 CCL3
20
Show member pathways
12.44 IL5 IL1R1 IL1A IL13
21
Show member pathways
12.43 IL6 IL5 IL17A IL13 CXCL8 CCL2
22
Show member pathways
12.41 PENK IL6 IL5 IL1A IL17A IL15
23
Show member pathways
12.32 IL6 IL1R1 IL1A CXCL8
24 12.31 IL6 IFNA1 CXCL8 CCL5 CCL2
25 12.28 TAC1 IL6 IL1A IL13 IL10 CXCL8
26 12.26 IL6 IL1A IL10 IFNA1
27 12.15 IL6 IL1A IL17A IL13 IL10 CXCL8
28 12.13 IL6 IL10 CXCL8 CCL2
29 12.13 IL6 IL1R1 IL1A CXCL8 CCL2 ACAN
30 12.1 IL7 IL6 IL5 IL15 IL10
31
Show member pathways
12.08 IL5 IL1R1 IL1A IL13
32 12.08 IL6 IL1A IL17A IL15 CXCL8 CCL5
33 12.06 IL6 IL1A CXCL8 CCL3 BMP2
34 12.03 IL6 IL15 CCL5 CCL2
35 12.02 IL7 IL6 IL5 IL1R1 IL1A
36 11.98 IL6 IL1R1 IL10 CXCL8
37 11.98 IL7 IL5 IL1R1 IL17A IL15 IL13
38 11.97 IL6 IL1A CXCL8 CCL2
39 11.88 IL6 IL5 IL13 CXCL8
40 11.84 IL6 IL1A IL10 CXCL8
41
Show member pathways
11.77 IL6 IL17A IL10
42 11.77 IL6 IL5 IL13 CXCL8 CCL5 CCL4
43 11.71 IL6 IL5 IL10
44 11.71 IL6 IL1R1 IL1A IL13 IL10 CXCL8
45
Show member pathways
11.69 IL6 IL1A CXCL8
46 11.65 IL6 IL10 CXCL8 CCL2
47 11.56 IL6 IL5 IL1A
48 11.54 IL5 IL13 IL10
49 11.52 IL7 IL6 IL5 IL17A IL15 IL13
50
Show member pathways
11.49 IL15 IL10 CCL4 CCL3

GO Terms for Radiculopathy

Cellular components related to Radiculopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 TAC1 IL7 IL6 IL5 IL1A IL17A
2 extracellular region GO:0005576 9.6 TAC1 PENK IL7 IL6 IL5 IL1R1

Biological processes related to Radiculopathy according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.23 TAC1 PENK CXCL8 CCL5 CCL4 CCL3
2 signal transduction GO:0007165 10.22 PENK IL7 IL6 IL5 IL1R1 IL15
3 negative regulation of cell proliferation GO:0008285 10.09 IL6 IL1A IL10 CXCL8 BMP2
4 positive regulation of gene expression GO:0010628 10.09 IL7 IL6 IL1A IL13 CXCL8 CCL3
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.02 CCL5 CCL4 CCL3 CCL2 BMP2
6 cellular response to lipopolysaccharide GO:0071222 10 IL6 IL1A IL10 CXCL8 CCL2
7 cytokine-mediated signaling pathway GO:0019221 10 IL7 IL6 IL5 IL1R1 IL1A IL17A
8 response to lipopolysaccharide GO:0032496 9.97 TAC1 PENK IL13 IL10
9 chemotaxis GO:0006935 9.97 CXCL8 CCL5 CCL4 CCL3 CCL2
10 cellular response to tumor necrosis factor GO:0071356 9.96 CXCL8 CCL5 CCL4 CCL3 CCL2
11 cellular response to interferon-gamma GO:0071346 9.94 CCL5 CCL4 CCL3 CCL2
12 response to toxic substance GO:0009636 9.93 PENK CCL5 CCL4 CCL3
13 positive regulation of tumor necrosis factor production GO:0032760 9.93 IL6 IL1A IL17A CCL3
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 IL6 IL15 IL13 CCL5
15 cellular response to organic cyclic compound GO:0071407 9.91 CCL5 CCL3 CCL2 BMP2
16 neutrophil chemotaxis GO:0030593 9.89 CXCL8 CCL5 CCL4 CCL3 CCL2
17 chemokine-mediated signaling pathway GO:0070098 9.88 CXCL8 CCL5 CCL4 CCL3 CCL2
18 cell chemotaxis GO:0060326 9.87 CCL5 CCL3 CCL2
19 humoral immune response GO:0006959 9.87 IL7 IL6 IFNA1 CCL2
20 positive regulation of T cell proliferation GO:0042102 9.86 IL6 IL15 CCL5
21 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 IL6 IL13 CCL5
22 cell-cell signaling GO:0007267 9.86 TAC1 IL7 IL17A IL15 CCL5 CCL4
23 positive regulation of interleukin-1 beta production GO:0032731 9.85 IL6 IL17A CCL3
24 sensory perception of pain GO:0019233 9.85 TAC1 PENK CCL2
25 positive regulation of cytokine production GO:0001819 9.85 IL1A IL15 IL10
26 positive regulation of B cell proliferation GO:0030890 9.84 IL7 IL5 IL13
27 lymphocyte chemotaxis GO:0048247 9.84 CCL5 CCL4 CCL3 CCL2
28 protein kinase B signaling GO:0043491 9.83 CCL5 CCL3 CCL2
29 cellular response to fibroblast growth factor stimulus GO:0044344 9.83 CXCL8 CCL5 CCL2
30 lipopolysaccharide-mediated signaling pathway GO:0031663 9.82 CCL5 CCL3 CCL2
31 positive regulation of calcium ion transport GO:0051928 9.82 CCL5 CCL4 CCL3
32 positive regulation of JAK-STAT cascade GO:0046427 9.81 IL6 IL5 IL10 CCL5
33 cellular response to interleukin-1 GO:0071347 9.8 IL17A CXCL8 CCL5 CCL4 CCL3 CCL2
34 immune response GO:0006955 9.8 IL7 IL6 IL5 IL1R1 IL1A IL17A
35 macrophage chemotaxis GO:0048246 9.78 CCL5 CCL3 CCL2
36 negative regulation by host of viral transcription GO:0043922 9.77 CCL5 CCL4 CCL3
37 monocyte chemotaxis GO:0002548 9.77 IL6 CCL5 CCL4 CCL3 CCL2
38 neutrophil activation GO:0042119 9.76 IL15 CXCL8 CCL5
39 positive regulation of immunoglobulin production GO:0002639 9.76 IL6 IL5 IL13 IL10
40 eosinophil chemotaxis GO:0048245 9.73 CCL5 CCL4 CCL3 CCL2
41 positive regulation of natural killer cell chemotaxis GO:2000503 9.7 CCL5 CCL4 CCL3
42 response to molecule of bacterial origin GO:0002237 9.69 IL10 CXCL8
43 astrocyte cell migration GO:0043615 9.67 CCL3 CCL2
44 positive regulation of cellular biosynthetic process GO:0031328 9.65 CXCL8 CCL5
45 inflammatory response GO:0006954 9.47 TAC1 IL6 IL5 IL1R1 IL1A IL17A

Molecular functions related to Radiculopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.8 IL7 IL6 IL5 IL10 BMP2
2 CCR chemokine receptor binding GO:0048020 9.56 CCL5 CCL4 CCL3 CCL2
3 CCR5 chemokine receptor binding GO:0031730 9.54 CCL5 CCL4 CCL3
4 CCR1 chemokine receptor binding GO:0031726 9.5 CCL5 CCL4 CCL3
5 cytokine activity GO:0005125 9.5 IL7 IL6 IL5 IL1A IL17A IL15
6 cytokine receptor binding GO:0005126 9.46 IL7 IL15 IL13 IFNA1
7 phospholipase activator activity GO:0016004 9.43 CCL5 CCL3
8 chemokine activity GO:0008009 9.35 CXCL8 CCL5 CCL4 CCL3 CCL2

Sources for Radiculopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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