Aliases & Classifications for Radiculopathy

MalaCards integrated aliases for Radiculopathy:

Name: Radiculopathy 12 43 15 71 32
Pinched Nerve 12 53
Nerve Root Disorder 71


External Ids:

Disease Ontology 12 DOID:4306
MeSH 43 D011843
ICD10 32 M54.1
UMLS 71 C0700594 C1527351

Summaries for Radiculopathy

NINDS : 53 The term "pinched nerve" is a colloquial term and not a true medical term.  It is used to describe one type of damage or injury to a nerve or set of nerves. The injury may result from compression, constriction, or stretching. Symptoms include numbness, "pins and needles" or burning sensations, and pain radiating outward from the injured area. One of the most common examples of a single compressed nerve is the feeling of having a foot or hand "fall asleep." A "pinched nerve" frequently is associated with pain in the neck or lower back.  This type of pain can be caused by inflammation or pressure on the nerve root as it exits the spine.  If the pain is severe or lasts a long time, you may need to have further evaluation from your physician.  Several problems can lead to similar symptoms of numbness, pain, and tingling in the hands or feet but without pain in the neck or back.  These can include peripheral neuropathy, carpal tunnel syndrome, and tennis elbow. The extent of such injuries may vary from minor, temporary damage to a more permanent condition. Early diagnosis is important to prevent further damage or complications. Pinched nerve is a common cause of on-the-job injury.

MalaCards based summary : Radiculopathy, also known as pinched nerve, is related to polyradiculopathy and whiplash, and has symptoms including neuralgia An important gene associated with Radiculopathy is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Methylprednisolone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A peripheral nervous system disease that is characterized by the pinching of a nerve root in the spine and has symptoms of pain, weakness, numbness and tingling.

Wikipedia : 74 Radiculopathy, also commonly referred to as pinched nerve, refers to a set of conditions in which one or... more...

Related Diseases for Radiculopathy

Diseases related to Radiculopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 741)
# Related Disease Score Top Affiliating Genes
1 polyradiculopathy 31.1 TAC1 RPL34 LAPTM4A IL6 HECTD4 BMP2
2 whiplash 30.9 CCL5 CCL4 CCL3
3 fibromyalgia 30.7 IL6 IL10 CXCL8 CCL2
4 exanthem 30.7 IL6 IL10 IFNA1 CXCL8
5 varicose veins 30.7 IL6 CXCL8 CCL2
6 carpal tunnel syndrome 30.7 TAC1 IL6 CCL2
7 spondylitis 30.7 IL6 IL17A IL10
8 cytokine deficiency 30.6 IL5 IL13
9 chickenpox 30.6 IL6 IL10 IFNA1
10 spondylosis 30.6 RPL34 HECTD4 BMP2 AVPR2
11 spondylolisthesis 30.5 RPL34 HECTD4 BMP2
12 myositis 30.5 IL6 IL1A IL17A IFNA1 CXCL8 CCL2
13 myelitis 30.5 IL6 IL17A IL10 CXCL8
14 bronchopneumonia 30.3 IL6 IL10 CXCL8
15 lyme disease 30.3 IL6 IL17A IFNA1
16 endometriosis 30.3 IL6 CXCL8 CCL5 CCL2
17 vasculitis 30.3 IL6 IL17A IL10 CCL2
18 chronic inflammatory demyelinating polyradiculoneuropathy 30.3 IL17A IL10 CCL5 CCL4
19 cerebral palsy 30.3 IL6 IL13 IL10 CXCL8
20 osteoarthritis 30.2 IL6 IL1A IL17A CXCL8 BMP2
21 neuromyelitis optica 30.2 IL6 IL5 IL17A IFNA1
22 cryptococcosis 30.2 IL17A IL13 IL10
23 infective endocarditis 30.2 IL6 IL17A CCL4
24 eosinophilic meningitis 30.2 IL5 IL13 IL10
25 aseptic meningitis 30.1 IL1A IL10 CXCL8 CCL3
26 spondyloarthropathy 30.1 IL6 IL17A IL10 CCL2
27 pulmonary fibrosis 30.1 IL13 CXCL8 CCL3 CCL2
28 temporal arteritis 30.1 IL6 IL17A CCL5 CCL2
29 cellulitis 30.1 IL6 IL5 IL17A IL10
30 mononeuropathy 30.1 TAC1 RPL34 HECTD4
31 burning mouth syndrome 30.0 TAC1 IL6 CXCL8
32 sarcoidosis 1 30.0 IL1A IL13 CCL5 CCL4 CCL3 CCL2
33 bacterial meningitis 30.0 IL6 IL17A IL10 CXCL8 CCL4 CCL2
34 polyradiculoneuropathy 29.9 RPL34 IL17A IL10 CCL5 CCL4
35 meningoencephalitis 29.8 TAC1 IL6 IL10 CCL5
36 hypereosinophilic syndrome 29.8 IL5 IL13 IL10 IFNA1 CXCL8 CCL5
37 endocarditis 29.8 IL6 IL1A IL17A IL10 CXCL8 CCL4
38 epicondylitis 29.7 TAC1 LAPTM4A HECTD4
39 bursitis 29.7 TAC1 LAPTM4A HECTD4
40 uveitis 29.6 IL6 IL1A IL17A IL10 CXCL8 CCL4
41 complex regional pain syndrome 29.5 TAC1 IL6 IL10 CXCL8 CCL4 CCL3
42 myofascial pain syndrome 29.4 TAC1 LAPTM4A HECTD4
43 peripheral nervous system disease 29.4 TAC1 RPL34 IL6 IL17A IL10 HECTD4
44 arthritis 29.4 IL6 IL1A IL17A IL13 IL10 CXCL8
45 allergic hypersensitivity disease 29.3 TAC1 IL5 IL17A IL13 IL10 CXCL8
46 demyelinating disease 29.2 IL6 IL17A IL10 IFNA1 CCL5 CCL4
47 meningitis 29.1 IL6 IL5 IL1A IL17A IL13 IL10
48 diabetes mellitus 29.1 IL6 IL1A IL17A IL10 CXCL8 CCL5
49 osteoporosis 29.1 IL7 IL6 IL1A IL17A IL10 IFNA1
50 osteomyelitis 29.1 IL6 IL1A IL13 IL10 CXCL8 CCL5

Graphical network of the top 20 diseases related to Radiculopathy:

Diseases related to Radiculopathy

Symptoms & Phenotypes for Radiculopathy

UMLS symptoms related to Radiculopathy:


GenomeRNAi Phenotypes related to Radiculopathy according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.66 IFNA1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.66 RPL34
3 Increased shRNA abundance (Z-score > 2) GR00366-A-134 9.66 IL17A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.66 IFNA1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-145 9.66 IFNA1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.66 IFNA1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-173 9.66 IL7
8 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.66 RPL34
9 Increased shRNA abundance (Z-score > 2) GR00366-A-175 9.66 IFNA1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-209 9.66 IFNA1 RPL34
11 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.66 IL17A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.66 RPL34
13 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.66 IL17A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-61 9.66 IFNA1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.66 IFNA1 RPL34
16 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.66 IFNA1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.66 IFNA1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-87 9.66 IL17A IL7 RPL34

Drugs & Therapeutics for Radiculopathy

Drugs for Radiculopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 188)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
Topiramate Approved Phase 4 97240-79-4 5284627
Norepinephrine Approved Phase 4 51-41-2 439260
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
Methadone Approved Phase 4 76-99-3 4095
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
Ibuprofen Approved Phase 4 15687-27-1 3672
Eplerenone Approved Phase 4 107724-20-9 150310 443872
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Acetaminophen Approved Phase 4 103-90-2 1983
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
24 Pharmaceutical Solutions Phase 4
25 Betamethasone benzoate Phase 4
26 Betamethasone Valerate Phase 4 2152-44-5
27 Betamethasone-17,21-dipropionate Phase 4
28 Betamethasone sodium phosphate Phase 4
29 Betamethasone acetate phosphate Phase 4
30 Neurotransmitter Agents Phase 4
31 Analgesics, Non-Narcotic Phase 4
32 Cyclooxygenase Inhibitors Phase 4
33 Antirheumatic Agents Phase 4
34 Anti-Inflammatory Agents, Non-Steroidal Phase 4
35 Antidepressive Agents Phase 4
36 Methylprednisolone Acetate Phase 4
37 Cyclooxygenase 2 Inhibitors Phase 4
38 Hypoglycemic Agents Phase 4
39 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
40 Analgesics Phase 4
41 Narcotics Phase 4
42 Analgesics, Opioid Phase 4
43 Antitussive Agents Phase 4
44 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
45 Anti-Anxiety Agents Phase 4
46 Psychotropic Drugs Phase 4
47 Anticonvulsants Phase 4
48 Calcium, Dietary Phase 4
49 calcium channel blockers Phase 4
50 Phosphodiesterase Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 302)
# Name Status NCT ID Phase Drugs
1 A Prospective Randomized Trails for Primary Disc Herniation With Radiculopathy:Conservative Versus Aggressive Discectomy Unknown status NCT01204008 Phase 4
2 A Post-marketing Evaluation of a Compound Traditional Chinese Herbal Medicine, Qishe Pill, on Cervical Radiculopathy Unknown status NCT01875562 Phase 4 Qishe Pill
3 Transforaminal Epidural Steroid Injection in Conjunction With Pulsed Radiofrequency Treatment of the Lumbar Dorsal Root Ganglion for the Management of Chronic Lumbosacral Radicular Pain: a Randomized, Double-blind Trial Unknown status NCT02930057 Phase 4 Celestone;Control
4 Comparison of the Efficacy of Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation of the Motor Cortex in Patients With Neuropathic Pain Due to Chronic Radiculopathy Completed NCT02030626 Phase 4
5 Efficacy Study of Caudal Epidural Steroid Injections in Patients With Low Back Pain/Radiculopathy Completed NCT01407913 Phase 4
6 Open Labelled Study of Pregabalin in the Treatment of Neuropathic Pain in Cervical Myeloradiculopathy (Pregabalin and Radicular Pain Study (PARPS)) Completed NCT01061697 Phase 4 Pregabalin
7 Arthroplasty Versus Fusion in Anterior Cervical Surgery: Prospective Study of the Impact on the Adjacent Level Completed NCT00554528 Phase 4
8 A Ten-Week, Randomized, Double-Blind, Placebo-Controlled Parallel-Group Study of Milnacipran for Radicular Pain Associated With Lumbosacral Disk Disease Completed NCT01777581 Phase 4 Milnacipran;Placebo
9 Efficacy of Pregabalin in Patients With Radicular Pain Completed NCT00908375 Phase 4 Pregabalin;Sugar Pill
10 A Prospective Randomized Controlled Trial of Standardized C7-T1 Epidural Steroid Injections Versus Targeted Injection Via Cervical Epidural Catheter for the Treatment of Cervical Radicular Pain Completed NCT02095197 Phase 4 Triamcinolone 80mg
11 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Determine the Effacy and Safety of Topiramate in Subjects With Restless Legs Syndrome (RLS) Completed NCT00200941 Phase 4 Topiramate
12 Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Completed NCT01615328 Phase 4
13 Single Blinded, Randomized Control Trial of High Frequency Stimulation in Subjects With Precision® Spinal Cord Stimulator System to Assess Efficacy and Preferability in Back and Extremity Pain Relief Completed NCT02265848 Phase 4
14 Comparison of the Efficacy of Corticosteroid Injection and Extracorporeal Shock Wave Therapy (ESWT) in Patients With Carpal Tunnel Syndrome; A Prospective Randomized Controlled Trial Completed NCT03792945 Phase 4 local injection
15 Improvement in Pain, Function and Quality of Life With a Protocolized Exercise Program Compared With Non-steroidal Anti-inflammatory Analgesics in Patients With Subacute Low Back Pain in Medellín, Colombia, 2009-2010 Completed NCT01374269 Phase 4 NSAID (Nonsteroidal anti-inflammatory drugs)
16 Combined Administration of Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Analgesia in Posterior Lumbar Spine Surgery - A Prospective Randomized Study Recruiting NCT03514277 Phase 4 Exparel;Bupivacaine
17 Do Cervical Interlaminar Epidural Steroid Injections With Low-dose Lidocaine Cause Transient Objective Upper Extremity Weakness? A Prospective Randomized Controlled Trial Recruiting NCT03127137 Phase 4 Experimental Group 1 triamcinolone and lidocaine;Experimental Group 2 triamcinolone and saline
18 Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients Recruiting NCT02989597 Phase 4 Methadone Hydrochloride
19 Prospective Controlled Crossover Study of the Role of Pentoxifylline in the Management of Lumbar Radiculopathy Active, not recruiting NCT03060434 Phase 4 Pentoxifylline Oral Tablet;Ibuprofen
20 A Prospective, Randomized, Multicenter Study to Demonstrate the Superiority of the Barricaid to Discectomy for Primary Lumbar Disc Herniation Active, not recruiting NCT01283438 Phase 4
21 A Prospective Randomized Comparative Trial of Targeted Injection Via a Transforaminal Approach With Dexamethasone Versus an Epidural Catheter Via an Interlaminar Approach With Particulate Steroid for the Treatment of Cervical Radicular Pain Active, not recruiting NCT03382821 Phase 4 Dexamethasone Sodium Phosphate 10 MG/ML;Lidocaine;Triamcinolone Acetonide 40mg/mL
22 Surgery Prevention by Transforaminal Injection of Epidural Steroids for Cervical Radicular Pain (SPIES): a Randomized, Controlled Trial Active, not recruiting NCT02226159 Phase 4 Lidocaine;Lidocaine with Dexamethasone
23 Epidural Steroid Injection With Supplemental Oral Eplerenone for Low Back Pain: A Prospective, Double Blind Randomized Trial Suspended NCT03418649 Phase 4 Eplerenone 50 Mg Tab;Placebo Oral Tablet
24 A Randomized Trial of CT-guided Perineural Injection With a Corticosteroid Plus a Long Acting Local Anesthetic Versus Standard Medical Management in Patients With Acute Lumbar Radiculopathy and a Corresponding Disc Herniation Terminated NCT01267825 Phase 4 CT-guided corticosteroid+ bupivicaine;Standard medical care
25 Spinal Cord Stimulation for Chronic and Intractable Back Pain in Patients Who Are Not Surgical Candidates Terminated NCT00370695 Phase 4
26 Single Center, Randomized PROspective Study Comparing Percutaneous HydroDiscectomy to Transforaminal Epidural Steroid Injections in the Treatment Of Radiculopathy Secondary to Lumbar Disc Herniation (PROPHESOR) Terminated NCT02414698 Phase 4 TESI
27 Do Cervical Interlaminar Epidural Steroid Injections With Low-dose Lidocaine Cause Transient Objective Upper Extremity Weakness? A Prospective Randomized Terminated NCT03382925 Phase 4 Lidocaine;Triamcinolone Acetonide;Normal saline
28 Pragmatic Randomized Prospective Study of Cervical Interlaminar Epidural Injection of Particulate Steroid and Cervical Transforaminal Epidural Injection of Non-particulate Steroid in Patients With Cervical Radicular Pain Withdrawn NCT03165825 Phase 4 Transforaminal Epidural Steroid Injection with Dexamethasone;Interlaminar Epidural Steroid Injection with Betamethasone
29 Particulate vs. Nonparticulate Epidural Steroid Injections for the Treatment of Symptomatic Unilateral Lumbar Foraminal Stenosis: a Prospective Double-blinded Randomized Study Withdrawn NCT03245671 Phase 4 Kenalog Injectable Product;Decadron Phosphate, Injectable
30 A Randomized Placebo-Controlled Trial of the Efficacy and Safety of Pregabalin in the Treatment of Subjects With Neuropathic Pain Associated With Lumbo-Sacral Radiculopathy Completed NCT00159705 Phase 3 pregabalin
31 Open Randomised Comparative Study of the Efficacy and Safety of Neuromultivit (Solution for Injections, 2 ml) in Patients With Vertebrogenic Radiculopathy Completed NCT02508805 Phase 3 Neuromultivit;Voltaren;Sirdalud
32 A Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Painful Lumbar Radiculopathy Completed NCT00120120 Phase 2, Phase 3 Lenalidomide (CC-5013)
33 A Phase III Study to Assess the Efficacy and Safety of Ralfinamide. Completed NCT01019824 Phase 3 Ralfinamide
34 A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy Completed NCT00733096 Phase 2, Phase 3 etanercept;methylprednisolone;normal saline
35 The Value of Traction in Treatment of Lumbar Radiculopathy. Completed NCT00942227 Phase 3
36 The Value of Mechanical Traction in the Treatment of Cervical Radiculopathy Completed NCT00979108 Phase 3
37 A Single Site, Phase 2B, Randomized, Double-Blind, Study to Assess the Efficacy, Safety, and Tolerability of Twice Daily Oral ALLOD-2 vs. Placebo in the Treatment of Chronic Low Back Pain (ANODYNE-4) Completed NCT03201393 Phase 2, Phase 3 ALLOD-2 Capsules;Placebo Capsules
38 Immediate Pain Relieving Effects of Sinbaro-3 Pharmaco-acupuncture in Low Back Pain Patients; A Randomized Controlled Trial Completed NCT02196129 Phase 3 Sinbaro-3;Hwangryun
39 A Prospective, Randomized, Multi-Center, Post-Approval Clinical Trial Evaluating the Long-Term (7 Year) Safety and Effectiveness of the PCM® Cervical Disc Completed NCT01905930 Phase 3
40 Clinical Research on the Efficacy and Safety of Bosinji on LBP and Radiculopathy by HIVD of L-spine; A Multicenter, Randomized, Controlled, Clinical Trial Completed NCT03386149 Phase 3 Bosinji;Loxonine tab.
41 The Effectiveness of Selective Nerve Root Injections in Preventing the Need for Surgery in Patients With Lumbar Disc Herniations Completed NCT01073995 Phase 3 Kenalog and Sensorcaine
42 A Prospective, Randomized, Controlled Clinical Investigation Comparing PCM® Cervical Disc Arthroplasty to Anterior Cervical Discectomy and Fusion: 2 Year Results From the US IDE Clinical Trial Completed NCT00578812 Phase 3
43 Physiotherapy Management of Lumbar Radicular Syndrome; Does Early Intervention Improve Outcomes? Completed NCT02618278 Phase 3
44 The Effectiveness of Manual Physical Therapy and Exercise for Mechanical Neck Disorders: A Randomized Controlled Trial Completed NCT00416117 Phase 2, Phase 3
45 A Randomized, Double-Blind, Parallel-Group Study of NUCYNTA (Tapentadol) Immediate Release vs. Oxycodone Immediate Release for the Treatment of Acute Low Back Pain Completed NCT00986180 Phase 3 NUCYNTA;Oxycodone IR
46 Oral Steroids in the Treatment of Acute Sciatica A Randomized Controlled Study Completed NCT00317447 Phase 3 Oral Prednisone
47 Corticosteroid Lumbar Epidural Analgesia for Radiculopathy (C.L.E.A.R.) Recruiting NCT03372161 Phase 3 SP-102;Placebo
48 A Multicenter, Randomized, Double-blind, Sham-controlled, Comparative Study of SI-6603 in Subjects With Lumbar Disc Herniation (Phase 3) Recruiting NCT03607838 Phase 3 SI-6603;Sham injection
49 Randomized Study of Orphenadrine` in the Treatment of Muscle Cramps in Patients With Cirrhosis Recruiting NCT02423395 Phase 3 orphenadrine;Placebo
50 Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Recruiting NCT03327272 Phase 3 Methylprednisolone;Saline

Search NIH Clinical Center for Radiculopathy

Cochrane evidence based reviews: radiculopathy

Genetic Tests for Radiculopathy

Anatomical Context for Radiculopathy

MalaCards organs/tissues related to Radiculopathy:

Spinal Cord, Bone, Testes, Dorsal Root Ganglion, Brain, Cortex, Skin

Publications for Radiculopathy

Articles related to Radiculopathy:

(show top 50) (show all 5925)
# Title Authors PMID Year
Is scan-negative cauda equina syndrome a functional neurological disorder? A pilot study. 61
32073712 2020
Etiology-Based Classification of Adjacent Segment Disease Following Lumbar Spine Fusion. 61
32523480 2020
New methods for diagnosing lumbar foraminal stenosis using dynamic digital tomosynthesis radiculography. 61
32387257 2020
Rare Case of Spinal Dural Arteriovenous Fistula with Radiculopathy, without Myelopathy or Spinal Edema on Magnetic Resonance Imaging. 61
32251830 2020
Evaluation of Persons with Suspected Lumbosacral and Cervical Radiculopathy: Electrodiagnostic Assessment and Implications for Treatment and Outcomes (PART I). 61
32557709 2020
Minimum 2-Year Efficacy of Percutaneous Endoscopic Lumbar Discectomy versus Microendoscopic Discectomy: A Meta-Analysis. 61
32109644 2020
Lumbar Extraosseous Intraforaminal Osteoblastoma: Case Report and Review of the Literature. 61
32217174 2020
Scoliosis, diabetes mellitus and total laminectomy at the 4th lumbar vertebra are independent risk factors for post-laminectomy fracture around the isthmus. 61
32502562 2020
Lumbosacral Radiculopathy as the Clinical Presentation of Neurocysticercosis. 61
32519649 2020
Coblation annuloplasty in cervical discogenic pain without radiculopathy. 61
32489491 2020
L5 Radiculopathy with Neurological Deficit Due To Sacral Insufficiency Fracture. 61
32482886 2020
Transcorporeal Tunnel Approach for Cervical Radiculopathy and Myelopathy: A Systematic Review and Meta-Analysis. 61
32217171 2020
CT-Guided Percutaneous Laser Disc Decompression for Lumbar Discogenic Radiculopathy-Performance of a Novel Combi-Therapy. 61
31475737 2020
Radiculopathy Following Vertebral Body Compression Fracture: The Role of Percutaneous Cement Augmentation. 61
32517398 2020
Evaluation of Persons with Suspected Lumbosacral and Cervical Radiculopathy: Electrodiagnostic Assessment and Implications for Treatment and Outcomes (PART II). 61
32564381 2020
Motor unit number index in quantitatively assessing motor root lesions and monitoring treatment outcomes in patients with lumbosacral radiculopathy. 61
32129891 2020
Criteria for Success after Surgery for Cervical Radiculopathy; Estimates for a Substantial Amount of Improvement in Core Outcome Measures. 61
32502657 2020
Ultrasound-Guided Lumbar Transforaminal Epidural Injection: A Narrative Review. 61
32521947 2020
Are Foraminal Stenosis Severity and Herniation Level Associated with the Treatment Success of Cervical Interlaminar Epidural Steroid Injection? 61
32517399 2020
Developmental anomalies of the lateral portion of the cervical neural arch: Multimodal imaging and clinical implications. 61
32401618 2020
Surgical anatomy of microsurgical 3-level anterior cervical discectomy and fusion C4-C7. 61
32563239 2020
Referral patterns for surgical consult in the management of patients with foot drop due to acute lumbar disc herniation: a survey study of physical therapists in the United States. 61
32530795 2020
The Feasibility and Perioperative Results of Bi-Portal Endoscopic Resection of a Facet Cyst Along With Minimizing Facet Joint Resection in the Degenerative Lumbar Spine. 61
31550357 2020
Tibial motor and sural electrophysiological relationship in subjects without and patients with mild axonal peripheral neuropathy. 61
31686383 2020
Deep Learning model for markerless tracking in spinal SBRT. 61
32422577 2020
Comparison of 1-year results of single transforaminal epidural steroid injection among patients with different spinal pathologies-related radicular pain. 61
32525120 2020
Does Concomitant Lumbar Spine Disease Adversely Affect the Outcomes of Patients Undergoing Hip Arthroscopy? 61
32551809 2020
Does the C3/4 disc play a role in cervical spondylosis with dizziness? A retrospective study. 61
32193610 2020
Ultrasound-guided Syringosubarachnoid Shunt Insertion for Cervicothoracic Syringomyelia. 61
31220040 2020
Advancement in Neuromodulation Technology with the Innovation of Design-Specific Peripheral Nerve Stimulators: Sural Nerve Stimulation for Radiculopathy. 61
32249315 2020
Evaluation of Anterior Decompression Surgical Outcomes of Proximal-Type Cervical Spondylotic Amyotrophy: A Retrospective Study. 61
32293800 2020
Radiographic Fusion Rates Following a Stand-alone Interbody Cage Versus an Anterior Plate Construct for Adjacent Segment Disease After Anterior Cervical Discectomy and Fusion. 61
31977677 2020
Crossing the Cervicothoracic Junction During Posterior Cervical Decompression and Fusion: Is It Necessary? 61
32315427 2020
The Effect of Thoracolumbar Pedicle Isthmus on Pedicle Screw Accuracy. 61
32435557 2020
Catastrophization, fear of movement, anxiety, and depression are associated with persistent, severe low back pain and disability. 61
32045707 2020
Morphological Characteristics and Clinical Significance of Computed Tomography and Magnetic Resonance Imaging Findings of Spinal Epidural Gas. 61
32535055 2020
CT fluoroscopy-guided transforaminal and intra-articular facet steroid injections for the treatment of cervical radiculopathy: injectate distribution patterns and association with clinical outcome. 61
32500194 2020
Anterior cervical discectomy and fusion versus posterior cervical foraminotomy for the treatment of single-level unilateral cervical radiculopathy: a meta-analysis. 61
32487109 2020
The Effect of Pre-Treatment Depression, Anxiety and Somatization Levels on Transforaminal Epidural Steroid Injection: A Prospective Observational Study. 61
32517403 2020
Cervical Epidural Steroid Injections: Incidence and Determinants of Subsequent Surgery. 61
32565316 2020
The spinal metastatic melanoma with unknown primary lesions presenting as radiculopathy:Case report and literature review. 61
32428722 2020
The effectiveness of shoe modifications and orthotics in the conservative treatment of Civinini-Morton syndrome: state of art. 61
32555077 2020
Balance Ability in Low Back Pain Patients With Lumbosacral Radiculopathy Evaluated With Tetrax: A Matched Case-Control Study. 61
32475097 2020
Treatment of cervical spondylotic radiculopathy with posterior percutaneous endoscopic cervical discectomy: Short-term outcomes of 24 cases. 61
32443351 2020
C4 radiculopathy misdiagnosed as myofascial pain syndrome in the upper trapezius. 61
32498538 2020
Association of quantitative sensory testing parameters with clinical outcome in patients with lumbar radiculopathy undergoing microdiscectomy. 61
32383177 2020
Baduanjin exercise for cervical spondylotic radiculopathy: A protocol for systematic review and meta-analysis. 61
32358384 2020
Utility of Posterior Longitudinal Ligament Resection During Anterior Cervical Decompression for Radiculopathy. 61
32035200 2020
Patient-Friendly Summary of the ACR Appropriateness Criteria: Cervical Neck Pain or Cervical Radiculopathy. 61
31926890 2020
Probing the mechanisms underpinning recovery in post-surgical patients with cervical radiculopathy using Bayesian networks. 61
31985097 2020

Variations for Radiculopathy

Expression for Radiculopathy

Search GEO for disease gene expression data for Radiculopathy.

Pathways for Radiculopathy

Pathways related to Radiculopathy according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
Show member pathways
14.06 IL7 IL6 IL5 IL1A IL17A IL13
Show member pathways
13.86 PENK IL7 IL6 IL5 IL1A IL17A
Show member pathways
13.7 IL7 IL6 IL5 IL1A IL17A IL13
Show member pathways
13.48 PENK IL7 IL6 IL5 IL1A IL17A
Show member pathways
13.4 PENK IL7 IL6 IL5 IL1A IL17A
Show member pathways
13.38 IL7 IL6 IL5 IL1A IL17A IL13
Show member pathways
13.17 PENK IL7 IL6 IL5 IL1A IL17A
Show member pathways
13.09 IL6 IL10 IFNA1 CXCL8 CCL5 CCL4
Show member pathways
Show member pathways
12.92 IL6 IL5 IL1A IL17A IL13 IL10
11 12.88 IL7 IL6 IL5 IL13 IFNA1 CXCL8
Show member pathways
Show member pathways
12.64 IL6 IL5 IL1A IL17A IL13 IL10
Show member pathways
12.63 IL6 IL5 IL1A IL17A IL10
15 12.6 IL17A IL10 IFNA1 CCL5 CCL2
Show member pathways
12.5 IL7 IL6 IL5 IL13 IL10 IFNA1
Show member pathways
12.44 IL6 IL10 CXCL8 CCL5 CCL4 CCL3
Show member pathways
12.4 IL6 IL5 IL17A IL13 CXCL8 CCL2
19 12.29 IL6 IFNA1 CXCL8 CCL5 CCL2
20 12.26 IL6 IL1A IL10 IFNA1
21 12.25 TAC1 IL6 IL1A IL13 IL10 CXCL8
Show member pathways
12.23 PENK IL6 IL5 IL1A IL17A IL13
23 12.1 IL6 IL1A IL17A IL13 IL10 CXCL8
24 12.06 IL6 IL10 CXCL8 CCL2
25 12.05 IL6 IL1A CXCL8 CCL2
26 12.03 IL7 IL6 IL5 IL10
27 12.01 IL6 IL1A CXCL8 CCL3 BMP2
28 11.99 IL6 IL1A IL17A CXCL8 CCL5 CCL3
29 11.96 IL6 IL1A CXCL8 CCL2
30 11.95 IL7 IL6 IL5 IL1A
31 11.9 IL7 IL5 IL17A IL13 IL10 CCL3
32 11.86 IL6 IL5 IL13 CXCL8
33 11.82 IL6 IL1A IL10 CXCL8
Show member pathways
11.68 IL6 IL1A CXCL8
35 11.61 IL6 IL10 CXCL8 CCL2
36 11.56 IL6 IL5 IL1A
37 11.56 IL6 IL5 IL13 CXCL8 CCL5 CCL4
38 11.53 IL5 IL13 IL10
39 11.44 IL7 IL6 IL5 IL17A IL13
Show member pathways
11.42 IL10 CCL4 CCL3
41 11.4 IL6 IL1A CCL5
42 11.4 IL6 IL1A IL10
43 11.39 IL6 CXCL8 CCL2
44 11.37 IL7 IL6 IL5 IL1A IL13 IL10
45 11.3 IL6 IL1A IL13 IL10 CXCL8 CCL5
46 11.25 IL5 IL13 IL10
47 10.87 IL6 IL5 IL13
48 10.37 PENK IL7 IL6 IL5 IL1A IL17A

GO Terms for Radiculopathy

Cellular components related to Radiculopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 TAC1 PENK IL7 IL6 IL5 IL1A
2 extracellular space GO:0005615 9.5 TAC1 IL7 IL6 IL5 IL1A IL17A

Biological processes related to Radiculopathy according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.26 PENK IL7 IL6 IL5 IL10 IFNA1
2 G protein-coupled receptor signaling pathway GO:0007186 10.23 TAC1 PENK CXCL8 CCL5 CCL4 CCL3
3 negative regulation of cell proliferation GO:0008285 10.09 IL6 IL1A IL10 CXCL8 BMP2 AVPR2
4 positive regulation of gene expression GO:0010628 10.08 IL7 IL6 IL1A IL13 CCL3 BMP2
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 10 CCL5 CCL4 CCL3 CCL2 BMP2
6 cellular response to lipopolysaccharide GO:0071222 9.99 IL6 IL1A IL10 CXCL8 CCL2
7 chemotaxis GO:0006935 9.97 CXCL8 CCL5 CCL4 CCL3 CCL2
8 response to lipopolysaccharide GO:0032496 9.96 TAC1 PENK IL13 IL10
9 cellular response to tumor necrosis factor GO:0071356 9.95 CXCL8 CCL5 CCL4 CCL3 CCL2
10 immune response GO:0006955 9.93 IL7 IL6 IL5 IL1A IL17A IL13
11 cellular response to interferon-gamma GO:0071346 9.92 CCL5 CCL4 CCL3 CCL2
12 response to toxic substance GO:0009636 9.92 PENK CCL5 CCL4 CCL3
13 cell-cell signaling GO:0007267 9.91 TAC1 IL7 IL17A CCL5 CCL4 CCL3
14 cellular response to organic cyclic compound GO:0071407 9.9 CCL5 CCL3 CCL2 BMP2
15 humoral immune response GO:0006959 9.87 IL7 IL6 IFNA1 CCL2
16 cell chemotaxis GO:0060326 9.86 CCL5 CCL3 CCL2
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 IL6 IL13 CCL5
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.84 IL6 IL13 CCL5
19 sensory perception of pain GO:0019233 9.84 TAC1 PENK CCL2
20 positive regulation of B cell proliferation GO:0030890 9.83 IL7 IL5 IL13
21 lymphocyte chemotaxis GO:0048247 9.83 CCL5 CCL4 CCL3 CCL2
22 neutrophil chemotaxis GO:0030593 9.83 CXCL8 CCL5 CCL4 CCL3 CCL2
23 protein kinase B signaling GO:0043491 9.82 CCL5 CCL3 CCL2
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.82 CCL5 CCL3 CCL2
25 cellular response to fibroblast growth factor stimulus GO:0044344 9.81 CXCL8 CCL5 CCL2
26 positive regulation of calcium ion transport GO:0051928 9.8 CCL5 CCL4 CCL3
27 positive regulation of JAK-STAT cascade GO:0046427 9.8 IL6 IL5 IL10 CCL5
28 chemokine-mediated signaling pathway GO:0070098 9.8 CXCL8 CCL5 CCL4 CCL3 CCL2
29 macrophage chemotaxis GO:0048246 9.76 CCL5 CCL3 CCL2
30 eosinophil chemotaxis GO:0048245 9.76 CCL5 CCL4 CCL3 CCL2
31 negative regulation by host of viral transcription GO:0043922 9.73 CCL5 CCL4 CCL3
32 cellular response to interleukin-1 GO:0071347 9.73 IL17A CXCL8 CCL5 CCL4 CCL3 CCL2
33 inflammatory response GO:0006954 9.73 TAC1 IL6 IL5 IL1A IL17A IL13
34 monocyte chemotaxis GO:0002548 9.72 IL6 CCL5 CCL4 CCL3 CCL2
35 positive regulation of natural killer cell chemotaxis GO:2000503 9.69 CCL5 CCL4 CCL3
36 positive regulation of immunoglobulin secretion GO:0051024 9.68 IL6 IL5
37 neutrophil activation GO:0042119 9.68 CXCL8 CCL5
38 PERK-mediated unfolded protein response GO:0036499 9.68 CXCL8 CCL2
39 response to molecule of bacterial origin GO:0002237 9.67 IL10 CXCL8
40 astrocyte cell migration GO:0043615 9.66 CCL3 CCL2
41 cytokine-mediated signaling pathway GO:0019221 9.44 IL7 IL6 IL5 IL1A IL17A IL13

Molecular functions related to Radiculopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.77 IL7 IL6 IL5 IL10 BMP2
2 cytokine receptor binding GO:0005126 9.58 IL7 IL13 IFNA1
3 CCR chemokine receptor binding GO:0048020 9.56 CCL5 CCL4 CCL3 CCL2
4 CCR5 chemokine receptor binding GO:0031730 9.5 CCL5 CCL4 CCL3
5 cytokine activity GO:0005125 9.47 IL7 IL6 IL5 IL1A IL17A IL13
6 phospholipase activator activity GO:0016004 9.43 CCL5 CCL3
7 chemokine activity GO:0008009 9.35 CXCL8 CCL5 CCL4 CCL3 CCL2
8 CCR1 chemokine receptor binding GO:0031726 9.33 CCL5 CCL4 CCL3

Sources for Radiculopathy

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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