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MCID: RDC002
MIFTS: 52

Radiculopathy

Categories: Bone diseases, Muscle diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Radiculopathy

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MalaCards integrated aliases for Radiculopathy:

Name: Radiculopathy 12 44 15 71 32
Pinched Nerve 12 53
Nerve Root Disorder 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Bone diseases Muscle diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:4306
MeSH 44 D011843
SNOMED-CT 67 394640000
ICD10 32 M54.1
UMLS 71 C0700594 C1527351
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Summaries for Radiculopathy

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NINDS : 53 The term "pinched nerve" is a colloquial term and not a true medical term.  It is used to describe one type of damage or injury to a nerve or set of nerves. The injury may result from compression, constriction, or stretching. Symptoms include numbness, "pins and needles" or burning sensations, and pain radiating outward from the injured area. One of the most common examples of a single compressed nerve is the feeling of having a foot or hand "fall asleep." A "pinched nerve" frequently is associated with pain in the neck or lower back.  This type of pain can be caused by inflammation or pressure on the nerve root as it exits the spine.  If the pain is severe or lasts a long time, you may need to have further evaluation from your physician.  Several problems can lead to similar symptoms of numbness, pain, and tingling in the hands or feet but without pain in the neck or back.  These can include peripheral neuropathy, carpal tunnel syndrome, and tennis elbow. The extent of such injuries may vary from minor, temporary damage to a more permanent condition. Early diagnosis is important to prevent further damage or complications. Pinched nerve is a common cause of on-the-job injury.

MalaCards based summary : Radiculopathy, also known as pinched nerve, is related to back pain and whiplash, and has symptoms including neuralgia An important gene associated with Radiculopathy is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Meloxicam and Pregabalin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and dorsal root ganglion, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A peripheral nervous system disease that is characterized by the pinching of a nerve root in the spine and has symptoms of pain, weakness, numbness and tingling.

Wikipedia : 74 Radiculopathy, also commonly referred to as pinched nerve, refers to a set of conditions in which one or... more...

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Related Diseases for Radiculopathy

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Diseases related to Radiculopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 805)
# Related Disease Score Top Affiliating Genes
1 back pain 31.6 IL6 IL1A
2 whiplash 30.6 CCL5 CCL4 CCL3
3 exanthem 30.5 IL6 IL10 IFNA1 CXCL8
4 spondylitis 30.5 IL6 IL17A IL10
5 fibromyalgia 30.5 IL6 IL10 CXCL8 CCL2
6 myositis 30.4 IL6 IL1A IL17A IFNA1 CXCL8
7 chickenpox 30.4 IL6 IL10 IFNA1
8 cytokine deficiency 30.3 IL5 IL13
9 osteoarthritis 30.2 IL6 IL1A IL17A CXCL8
10 carpal tunnel syndrome 30.2 TAC1 IL6 CCL2
11 spondyloarthropathy 1 30.2 IL6 IL1R1 IL17A
12 endometriosis 30.1 IL6 CXCL8 CCL5 CCL2
13 aortic aneurysm, familial abdominal, 1 30.1 IL6 IL10 CXCL8 CCL2
14 lyme disease 30.1 IL6 IL17A IFNA1
15 polyradiculoneuropathy 30.0 IL17A IL10 CCL5 CCL4
16 chronic inflammatory demyelinating polyradiculoneuropathy 30.0 IL17A IL10 CCL5 CCL4
17 cerebral palsy 30.0 IL6 IL13 IL10 CXCL8
18 cryptococcosis 29.9 IL17A IL13 IL10
19 infective endocarditis 29.9 IL6 IL17A CCL4
20 scrub typhus 29.9 IL17A IL15 IL10
21 neuromyelitis optica 29.9 IL6 IL5 IL17A IFNA1
22 cysticercosis 29.9 IL6 IL5 IL10
23 spondyloarthropathy 29.9 IL6 IL17A IL10 CCL2
24 peripheral nervous system disease 29.9 TAC1 IL6 IL17A IL10 CXCL8 CCL2
25 temporal arteritis 29.9 IL6 IL17A CCL5 CCL2
26 pulmonary fibrosis 29.8 IL13 CXCL8 CCL3 CCL2
27 myelitis 29.8 IL6 IL17A IL10 CXCL8 CCL11
28 bacterial meningitis 29.7 IL6 IL17A IL10 CXCL8 CCL4 CCL2
29 bronchopneumonia 29.7 IL6 IL17A IL10 CXCL8 CCL3
30 cellulitis 29.7 IL6 IL5 IL1R1
31 arachnoiditis 29.6 TAC1 IL1A
32 endocarditis 29.5 IL6 IL1A IL17A IL10 CXCL8 CCL4
33 aseptic meningitis 29.5 IL1R1 IL1A IL10 CXCL8 CCL3
34 burning mouth syndrome 29.5 TAC1 IL6 CXCL8
35 eosinophilic meningitis 29.5 IL5 IL13 IL10 CCL11
36 mycobacterium tuberculosis 1 29.5 IL7 IL17A IL10 CCL4 CCL3
37 pain agnosia 29.4 TAC1 PENK IL6
38 bursitis 29.4 TAC1 LAPTM4A IL6
39 leukemia, acute myeloid 29.4 IL7 IL6 IL15 IL10 IFNA1 CXCL8
40 meningoencephalitis 29.4 TAC1 IL6 IL10 CCL5
41 shoulder impingement syndrome 29.3 TAC1 LAPTM4A
42 osteomyelitis 29.3 IL6 IL1A IL10 CXCL8 CCL2 BMP2
43 hypereosinophilic syndrome 29.1 IL5 IL13 IL10 IFNA1 CXCL8 CCL5
44 sarcoidosis 1 29.1 IL1A IL15 IL13 CCL5 CCL4 CCL3
45 osteoporosis 29.1 IL7 IL6 IL1A IL17A IL10 CXCL8
46 demyelinating disease 29.0 IL6 IL17A IL10 IFNA1 CCL5 CCL4
47 myofascial pain syndrome 29.0 TAC1 LAPTM4A
48 meningitis 28.8 IL6 IL5 IL1A IL17A IL13 IL10
49 migraine with or without aura 1 28.8 TAC1 LAPTM4A IL6 IL10
50 complex regional pain syndrome 28.8 TAC1 IL6 IL10 CXCL8 CCL4 CCL3

Graphical network of the top 20 diseases related to Radiculopathy:



Diseases related to Radiculopathy
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Symptoms & Phenotypes for Radiculopathy

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UMLS symptoms related to Radiculopathy:


neuralgia

MGI Mouse Phenotypes related to Radiculopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 BMP2 CCL11 CCL5 IL10 IL13 IL15
2 immune system MP:0005387 9.44 BMP2 CCL11 CCL2 CCL5 IL10 IL13
Sources

Drugs & Therapeutics for Radiculopathy

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Drugs for Radiculopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 130)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
2
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
3
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
4
Ibuprofen Approved Phase 4 15687-27-1 3672
5
Eplerenone Approved Phase 4 107724-20-9 150310 443872
6
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
7
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
8
Acetaminophen Approved Phase 4 103-90-2 1983
9
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
10
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
11
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
12
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 11103-57-4 445354
13 Betamethasone sodium phosphate Phase 4
14 Betamethasone benzoate Phase 4
15 Betamethasone-17,21-dipropionate Phase 4
16 Betamethasone acetate phosphate Phase 4
17 Betamethasone Valerate Phase 4 2152-44-5
18 Cyclooxygenase 2 Inhibitors Phase 4
19 retinol Phase 4
20 Retinol palmitate Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Anti-Inflammatory Agents, Non-Steroidal Phase 4
23 Cyclooxygenase Inhibitors Phase 4
24 Analgesics Phase 4
25 Antirheumatic Agents Phase 4
26 Anticonvulsants Phase 4
27 Psychotropic Drugs Phase 4
28 Anti-Anxiety Agents Phase 4
29 Calcium, Dietary Phase 4
30 calcium channel blockers Phase 4
31 Radiation-Protective Agents Phase 4
32 Antioxidants Phase 4
33 Phosphodiesterase Inhibitors Phase 4
34 Platelet Aggregation Inhibitors Phase 4
35 Vasodilator Agents Phase 4
36 Antipyretics Phase 4
37 HIV Protease Inhibitors Phase 4
38
protease inhibitors Phase 4
39 Dexamethasone 21-phosphate Phase 4
40 Antihypertensive Agents Phase 4
41 diuretics Phase 4
42 Mineralocorticoid Receptor Antagonists Phase 4
43 Mineralocorticoids Phase 4
44 Immunosuppressive Agents Phase 4
45 Immunologic Factors Phase 4
46 Sodium Channel Blockers Phase 4
47 Anesthetics Phase 4
48 Triamcinolone hexacetonide Phase 4
49 Anti-Arrhythmia Agents Phase 4
50 triamcinolone acetonide Phase 4

Interventional clinical trials:

(show top 50) (show all 225)
# Name Status NCT ID Phase Drugs
1 A Post-marketing Evaluation of a Compound Traditional Chinese Herbal Medicine, Qishe Pill, on Cervical Radiculopathy Unknown status NCT01875562 Phase 4 Qishe Pill
2 A Prospective Randomized Trails for Primary Disc Herniation With Radiculopathy:Conservative Versus Aggressive Discectomy Unknown status NCT01204008 Phase 4
3 Transforaminal Epidural Steroid Injection in Conjunction With Pulsed Radiofrequency Treatment of the Lumbar Dorsal Root Ganglion for the Management of Chronic Lumbosacral Radicular Pain: a Randomized, Double-blind Trial Unknown status NCT02930057 Phase 4 Celestone;Control
4 Comparison of the Efficacy of Repetitive Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation of the Motor Cortex in Patients With Neuropathic Pain Due to Chronic Radiculopathy Completed NCT02030626 Phase 4
5 Efficacy Study of Caudal Epidural Steroid Injections in Patients With Low Back Pain/Radiculopathy Completed NCT01407913 Phase 4
6 Arthroplasty Versus Fusion in Anterior Cervical Surgery: Prospective Study of the Impact on the Adjacent Level Completed NCT00554528 Phase 4
7 A Prospective Randomized Controlled Trial of Standardized C7-T1 Epidural Steroid Injections Versus Targeted Injection Via Cervical Epidural Catheter for the Treatment of Cervical Radicular Pain Completed NCT02095197 Phase 4 Triamcinolone 80mg
8 Open Labelled Study of Pregabalin in the Treatment of Neuropathic Pain in Cervical Myeloradiculopathy (Pregabalin and Radicular Pain Study (PARPS)) Completed NCT01061697 Phase 4 Pregabalin
9 Single Blinded, Randomized Control Trial of High Frequency Stimulation in Subjects With Precision® Spinal Cord Stimulator System to Assess Efficacy and Preferability in Back and Extremity Pain Relief Completed NCT02265848 Phase 4
10 Efficacy of Pregabalin in Patients With Radicular Pain Completed NCT00908375 Phase 4 Pregabalin;Sugar Pill
11 Defining the Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy Recruiting NCT03801356 Phase 4 Selective Nerve Root Block
12 The Effectiveness of Cervical Transforaminal Epidural Steroid Injection for the Treatment of Cervical Radicular Pain: A Prospective Cohort Study. Recruiting NCT04544683 Phase 4 Cervical Transforaminal Epidural Injection with dexamethasone sodium phosphate
13 Do Cervical Interlaminar Epidural Steroid Injections With Low-dose Lidocaine Cause Transient Objective Upper Extremity Weakness? A Prospective Randomized Controlled Trial Recruiting NCT03127137 Phase 4 Experimental Group 1 triamcinolone and lidocaine;Experimental Group 2 triamcinolone and saline
14 Prospective Controlled Crossover Study of the Role of Pentoxifylline in the Management of Lumbar Radiculopathy Active, not recruiting NCT03060434 Phase 4 Pentoxifylline Oral Tablet;Ibuprofen
15 A Prospective Randomized Comparative Trial of Targeted Injection Via a Transforaminal Approach With Dexamethasone Versus an Epidural Catheter Via an Interlaminar Approach With Particulate Steroid for the Treatment of Cervical Radicular Pain Active, not recruiting NCT03382821 Phase 4 Dexamethasone Sodium Phosphate 10 MG/ML;Lidocaine;Triamcinolone Acetonide 40mg/mL
16 Epidural Steroid Injection With Supplemental Oral Eplerenone for Low Back Pain: A Prospective, Double Blind Randomized Trial Suspended NCT03418649 Phase 4 Eplerenone 50 Mg Tab;Placebo Oral Tablet
17 A Randomized Trial of CT-guided Perineural Injection With a Corticosteroid Plus a Long Acting Local Anesthetic Versus Standard Medical Management in Patients With Acute Lumbar Radiculopathy and a Corresponding Disc Herniation Terminated NCT01267825 Phase 4 CT-guided corticosteroid+ bupivicaine;Standard medical care
18 Single Center, Randomized PROspective Study Comparing Percutaneous HydroDiscectomy to Transforaminal Epidural Steroid Injections in the Treatment Of Radiculopathy Secondary to Lumbar Disc Herniation (PROPHESOR) Terminated NCT02414698 Phase 4 TESI
19 Do Cervical Interlaminar Epidural Steroid Injections With Low-dose Lidocaine Cause Transient Objective Upper Extremity Weakness? A Prospective Randomized Terminated NCT03382925 Phase 4 Lidocaine;Triamcinolone Acetonide;Normal saline
20 Combined Administration of Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Analgesia in Posterior Lumbar Spine Surgery - A Prospective Randomized Study Terminated NCT03514277 Phase 4 Exparel;Bupivacaine
21 Pragmatic Randomized Prospective Study of Cervical Interlaminar Epidural Injection of Particulate Steroid and Cervical Transforaminal Epidural Injection of Non-particulate Steroid in Patients With Cervical Radicular Pain Withdrawn NCT03165825 Phase 4 Transforaminal Epidural Steroid Injection with Dexamethasone;Interlaminar Epidural Steroid Injection with Betamethasone
22 A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy Completed NCT00733096 Phase 2, Phase 3 etanercept;methylprednisolone;normal saline
23 A Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Painful Lumbar Radiculopathy Completed NCT00120120 Phase 2, Phase 3 Lenalidomide (CC-5013)
24 A Randomized Placebo-Controlled Trial of the Efficacy and Safety of Pregabalin in the Treatment of Subjects With Neuropathic Pain Associated With Lumbo-Sacral Radiculopathy Completed NCT00159705 Phase 3 pregabalin
25 Open Randomised Comparative Study of the Efficacy and Safety of Neuromultivit (Solution for Injections, 2 ml) in Patients With Vertebrogenic Radiculopathy Completed NCT02508805 Phase 3 Neuromultivit;Voltaren;Sirdalud
26 The Value of Traction in Treatment of Lumbar Radiculopathy. Completed NCT00942227 Phase 3
27 Clinical Research on the Efficacy and Safety of Bosinji on LBP and Radiculopathy by HIVD of L-spine; A Multicenter, Randomized, Controlled, Clinical Trial Completed NCT03386149 Phase 3 Bosinji;Loxonine tab.
28 The Value of Mechanical Traction in the Treatment of Cervical Radiculopathy Completed NCT00979108 Phase 3
29 A Prospective, Randomized, Controlled Clinical Investigation Comparing PCM® Cervical Disc Arthroplasty to Anterior Cervical Discectomy and Fusion: 2 Year Results From the US IDE Clinical Trial Completed NCT00578812 Phase 3
30 The Effectiveness of Selective Nerve Root Injections in Preventing the Need for Surgery in Patients With Lumbar Disc Herniations Completed NCT01073995 Phase 3 Kenalog and Sensorcaine
31 A Prospective, Randomized, Multi-Center, Post-Approval Clinical Trial Evaluating the Long-Term (7 Year) Safety and Effectiveness of the PCM® Cervical Disc Completed NCT01905930 Phase 3
32 Immediate Pain Relieving Effects of Sinbaro-3 Pharmaco-acupuncture in Low Back Pain Patients; A Randomized Controlled Trial Completed NCT02196129 Phase 3 Sinbaro-3;Hwangryun
33 The Effectiveness of Manual Physical Therapy and Exercise for Mechanical Neck Disorders: A Randomized Controlled Trial Completed NCT00416117 Phase 2, Phase 3
34 Physiotherapy Management of Lumbar Radicular Syndrome; Does Early Intervention Improve Outcomes? Completed NCT02618278 Phase 3
35 A Single Site, Phase 2B, Randomized, Double-Blind, Study to Assess the Efficacy, Safety, and Tolerability of Twice Daily Oral ALLOD-2 vs. Placebo in the Treatment of Chronic Low Back Pain (ANODYNE-4) Completed NCT03201393 Phase 2, Phase 3 ALLOD-2 Capsules;Placebo Capsules
36 Corticosteroid Lumbar Epidural Analgesia for Radiculopathy (C.L.E.A.R.) Recruiting NCT03372161 Phase 3 SP-102;Placebo
37 A Prospective Registry Study Evaluating the Safety and Efficacy of Fibrin for Chronic Multi-level Discogenic Low Back Pain Recruiting NCT04621799 Phase 2, Phase 3 Fibrin sealant
38 Study of Bone of Marrow Concentrate (BMC) Injection in Discs, Facets, Sacroiliac Joints, and Epidural Space for Chronic Lower Back Pain With and Without Radiculopathy Active, not recruiting NCT04559295 Phase 2, Phase 3
39 A Prospective, Multicenter, Randomized, Double-Blinded, Sham-Control Study to Evaluate the Efficacy and Safety of Clonidine Micropellets for the Treatment of Pain Associated With Lumbosacral Radiculopathy in Adults Active, not recruiting NCT03727100 Phase 3
40 A Prospective, Multi-center, Pivotal Trial for INFUSE® Bone Graft With CAPSTONE® Spinal System and Posterior Supplemental Fixation to Treat 1- or 2-level Advanced Degenerative Disease of the Lumbosacral Spine For a TLIF Approach Terminated NCT01415908 Phase 3
41 Randomized, Prospective Study of Lumbar Transforaminal Epidural Corticosteroid Injection(s) Versus Defined Physical Therapy for the Treatment of Subacute Lumbar Radicular Pain Due to Disc Protrusion Terminated NCT01443819 Phase 3
42 Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Withdrawn NCT03327272 Phase 3 Methylprednisolone;Saline
43 REN-1654 in Sciatica: A Phase 2, Randomized, Double-Blind, Placebo Controlled, Multi-Center Study in Subjects With Pain Due to Lumbosacral Radiculopathy Unknown status NCT00107055 Phase 2 REN-1654
44 Effectiveness of a Compound Traditional Chinese Herbal Medicine, Qishe Pill, on Cervical Radiculopathy: a Randomized, Double-blind, Placebo-controlled, Multicentre Trial Unknown status NCT01274936 Phase 2 Qishe Pill;Qishe Placebo
45 Effect of Conservative Treatment With Cervical Collar in Patients With Cervical Radiculopathy and Radicular Pain. A Randomized Controlled Study Completed NCT00395798 Phase 2
46 A Randomised, Double Blind Study to Evaluate the Safety and Efficacy of the p38 Kinase Inhibitor, GW856553, in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy Completed NCT01110057 Phase 2 Placebo;GS856553
47 An Open-Label, Sequential, Dose Escalation Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy Completed NCT01917825 Phase 2 MDT-15
48 A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Study Using a Bayesian Adaptive Design to Assess the Efficacy, Safety, Tolerability, and Serum Exposure of Multiple Doses of BG00010 (Neublastin) in Subjects With Painful Lumbar Radiculopathy Completed NCT01873404 Phase 2 BG00010;Placebo
49 A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate The Efficacy and Safety of Z160 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy Completed NCT01655849 Phase 2 z160;Placebo
50 A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy Completed NCT02935608 Phase 2 BIIB074;Placebo

Search NIH Clinical Center for Radiculopathy

Cochrane evidence based reviews: radiculopathy

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Genetic Tests for Radiculopathy

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Sources

Anatomical Context for Radiculopathy

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MalaCards organs/tissues related to Radiculopathy:

40
Spinal Cord, Bone, Dorsal Root Ganglion, Skin, Myeloid, Cortex, Bone Marrow
Sources

Publications for Radiculopathy

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Articles related to Radiculopathy:

(show top 50) (show all 6169)
# Title Authors PMID Year
1
Validation of the Nepali versions of the Neck Disability Index and the Numerical Rating Scale for Neck Pain. 61
33181772 2021
2
Validation of the Questionnaire for Symptom Assessment in Pain disorders for Back pain patients (Q-SAP). 61
33131154 2021
3
The effects of age, pathology, and fusion on cervical neural foramen area. 61
32167190 2021
4
Diagnostic usefulness of denervation edema in the multifidus muscles using 3-Tesla magnetic resonance imaging in cervical radiculopathy. 61
33314190 2021
5
Jingshu Keli for treating cervical spondylotic radiculopathy: The first multicenter, randomized, controlled clinical trial. 61
33376673 2021
6
Findings of Electrodiagnostic Studies in Moderate to Severe Lumbar Central Spinal Stenosis-Electrodiagnostic Studies in Lumbar Central Spinal Stenosis. 61
33546388 2021
7
Local Retropharyngeal Space Anesthetic for Dysphagia Reduction after Anterior Cervical Discectomy and Fusion Surgery: A Single-Center, Prospective, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. 61
33309893 2021
8
Do Preoperative Epidural Steroid Injections Increase the Risk of Infection After Lumbar Spine Surgery? 61
33079913 2021
9
Prolonged median distal sensory nerve action potential duration in carpal tunnel syndrome. 61
33533066 2021
10
Sprengel Deformity with Omovertebral Bone Encroaching the Spinal Canal Causing Progressive Cervical Myelopathy: A Technical Case Report. 61
33220477 2021
11
Efficacy and toxicity of re-irradiation spine stereotactic body radiotherapy with respect to irradiation dose history. 61
33020807 2021
12
A cross-sectional analysis of 1347 complications for cervical disc replacements from medical device reports maintained by the United States Food and Drug Administration. 61
32966907 2021
13
Anterior Cervical Discectomy With Fusion and Plating for Correction of Degenerative Cervical Kyphosis: 2-Dimensional Operative Video. 61
33372964 2021
14
Early Catastrophic Failure of Cervical Disc Arthroplasty: A Case Report. 61
33577187 2021
15
Is Cervical Disc Replacement Valuable in 3-Level Hybrid Surgery Compared with 3-Level Anterior Cervical Discectomy and Fusion? 61
33075576 2021
16
Markers of Cardiovascular Health in Older Adults with and Without Chronic Low Back and Radicular Leg Pain: A Comparative Analysis. 61
33585935 2021
17
Is a tourniquet necessary in arthroscopic anterior cruciate ligament reconstruction?: A randomized controlled study protocol. 61
33592830 2021
18
When Indirect Decompression Fails: A Review of 220 Consecutive Direct Lateral Interbody Fusions and Unplanned Secondary Decompression. 61
33534521 2021
19
Posterior endoscopic cervical foramiotomy and discectomy: clinical and radiological computer tomography evaluation on the bony effect of decompression with 2 years follow-up. 61
33078265 2021
20
Pulsed Electromagnetic Fields Accelerate Sensorimotor Recovery Following Experimental Disc Herniation. 61
33475275 2021
21
Prospective, multicenter clinical trial comparing M6-C compressible six degrees of freedom cervical disc with anterior cervical discectomy and fusion for the treatment of single-level degenerative cervical radiculopathy: 2-year results of an FDA investigational device exemption study. 61
33096243 2021
22
Long-term clinical and radiological outcomes of anterior uncoforaminotomy for unilateral single-level cervical radiculopathy: retrospective cohort study. 61
33545373 2021
23
Mechanisms of recovery after neck-specific or general exercises in patients with cervical radiculopathy. 61
33533164 2021
24
Predictive Effect of Intervertebral Foramen Width on Pain Relief After ACDF for the Treatment of Cervical Radiculopathy. 61
33557606 2021
25
Cervical Myeloradiculopathy and Atlantoaxial Instability in Cervical Dystonia. 61
33285336 2021
26
Do Thoracic Spinal Deformities Affect Outcomes of Spinal Cord Stimulators: A Retrospective Chart Review. 61
33079911 2021
27
Chronic inferior vena cava filter thrombosis presenting with low back pain and radiculopathy: Treatment with thrombolysis, filter removal, and stenting. 61
33607420 2021
28
Masquerading Guillain-Barré syndrome: uncommon, in-hospital presentation of Miller-Fisher syndrome shadowed by secondary diseases. 61
33541995 2021
29
Diagnosis, Management, and Current Treatment Options: A Cervical Spine Osteochondroma Meta-Analysis. 61
33561553 2021
30
Young adults undergoing ACDF surgery exhibit decreased health-related quality of life in the long term in comparison to the general population. 61
33545372 2021
31
Preoperative and Postoperative Opioid Dependence in Patients Undergoing Anterior Cervical Diskectomy and Fusion for Degenerative Spinal Disorders. 61
33540452 2021
32
[Epidural lipomatosis : management proposal]. 61
33543850 2021
33
Inflammation in the intervertebral disc herniation. 61
32169419 2021
34
Evaluation and Treatment of Foot Drop Using Nerve Transfer Techniques. 61
33220746 2021
35
Musculoskeletal Pain Symptoms and Injuries Among Endoscopists Who Perform ERCP. 61
32144599 2021
36
[Back pain in the primary care setting : Specific back pain]. 61
33355682 2021
37
Unintended fusion in cervical artificial disk replacement: a prospective study on heterotopic ossification, progression, and clinical outcome, with 5-year follow-up. 61
33471181 2021
38
Annular closure device breakage due to recurrent lumbar disc herniation: a case report. 61
33222009 2021
39
US-guided transforaminal cervical nerve root block: a novel lateral in-plane approach. 61
33502517 2021
40
A New Target for Hodgkin Lymphoma - Camidanlumab Tesirine. 61
33492560 2021
41
Diagnostic agreement between 3.0-T MRI sequences of nerve root and surgery in patients with cervical radiculopathy: A retrospective study. 61
33530213 2021
42
Clinical control study of traditional Chinese medicine hot compress combined with traction in the treatment of cervical spondylotic radiculopathy: Study protocol. 61
33530182 2021
43
A Retrospective Pilot Study for Preoperative Screening to Prevent Iatrogenic Cervical Spinal Cord Injury. 61
33564543 2021
44
A Case of Seronegative Pediatric Neurobrucellosis Presenting With Ataxia. 61
33564536 2021
45
The relationship between alexithymia, sensory phenotype and neurophysiological parameters in patients with chronic upper limb neuropathy. 61
33315145 2021
46
Differential Diagnosis of Facet Joint Disorders. 61
33481690 2021
47
Postpartum bilateral sacral stress fracture without osteoporosis-a case report and literature review. 61
33439310 2021
48
Simultaneous Robotic Single-Position Surgery With Oblique Lumbar Interbody Fusion With Software Planning: 2-Dimensional Operative Video. 61
33442749 2021
49
Transforaminal Endoscopic Surgical Treatment for Posterior Migration of Polyetheretherketone Transforaminal Lumbar Interbody Fusion Cage: Case Series. 61
33359521 2021
50
Minimally Invasive Posterior Cervical Foraminotomy Using 3-Dimensional Total Navigation: 2-Dimensional Operative Video. 61
33047126 2021
Sources

Variations for Radiculopathy

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Expression for Radiculopathy

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Search GEO for disease gene expression data for Radiculopathy.
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Pathways for Radiculopathy

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Pathways related to Radiculopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.07 IL7 IL6 IL5 IL1R1 IL1A IL17A
2
ERK Signaling 63
Show member pathways
 13.91 PENK IL7 IL6 IL5 IL1R1 IL1A
3
PEDF Induced Signaling 63
Show member pathways
 13.75 IL7 IL6 IL5 IL1R1 IL1A IL17A
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.27 IL7 IL6 IL5 IL1R1 IL1A IL17A
5
PAK Pathway 63
Show member pathways
 13.15 PENK IL7 IL6 IL5 IL1R1 IL1A
6
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.14 IL6 IL10 IFNA1 CXCL8 CCL5 CCL4
7
Akt Signaling 63
Show member pathways
 13.03 PENK IL7 IL6 IL5 IL1R1 IL1A
8
Human cytomegalovirus infection 36
Show member pathways
 13.02 IL6 IL1R1 IFNA1 CXCL8 CCL5 CCL4
9
Allograft rejection 36 1
Show member pathways
 13 IL6 IL5 IL1A IL17A IL15 IL13
10
CCR5 Pathway in Macrophages 63
Show member pathways
 12.93 CXCL8 CCL5 CCL4 CCL3 CCL2 CCL11
11
Pathways in cancer 36
12.93 IL7 IL6 IL5 IL15 IL13 IFNA1
12
Measles 36
Show member pathways
 12.87 IL6 IL1A IFNA1 CXCL8 CCL5 CCL2
13
TGF-Beta Pathway 63
Show member pathways
 12.82 PENK IL7 IL6 IL5 IL1R1 IL1A
14
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.75 IL6 IL1R1 IL1A IFNA1 CXCL8
15
NF-KappaB Family Pathway 63
Show member pathways
 12.73 PENK IL6 IL1R1 IL1A BMP2
16
Th17 cell differentiation 36
Show member pathways
 12.69 IL6 IL5 IL1R1 IL1A IL17A IL13
17
T cell receptor signaling pathway 36
Show member pathways
 12.64 IL6 IL5 IL1A IL17A IL10
18
NF-kappaB Signaling 4
12.61 IL17A IL10 IFNA1 CCL5 CCL2
19
JAK-STAT signaling pathway 36
Show member pathways
 12.53 IL7 IL6 IL5 IL15 IL13 IL10
20
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.5 IL6 IL10 CXCL8 CCL5 CCL4 CCL3
21
IL-17 Family Signaling Pathways 64
Show member pathways
 12.46 IL6 IL5 IL17A IL13 CXCL8 CCL2
22
Apoptosis Pathway 70
Show member pathways
 12.45 IL5 IL1R1 IL1A IL13
23
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.41 PENK IL6 IL5 IL1A IL17A IL15
24
Toll Comparative Pathway 63
Show member pathways
 12.32 IL6 IL1R1 IL1A CXCL8
25
NOD-like receptor signaling pathway 36
12.32 IL6 IFNA1 CXCL8 CCL5 CCL2
26
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.29 TAC1 IL6 IL1A IL13 IL10 CXCL8
27
Tuberculosis 36
12.27 IL6 IL1A IL10 IFNA1
28
Bacterial infections in CF airways 23
Show member pathways
 12.23 IL6 IL1R1 CXCL8 CCL11
29
Interleukin-4 and 13 signaling 65
12.2 IL6 IL1A IL17A IL13 IL10 CXCL8
30
Yersinia infection 36
12.14 IL6 IL10 CXCL8 CCL2
31
Spinal Cord Injury 1
12.12 IL6 IL1R1 IL1A CXCL8 CCL2
32
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.1 IL7 IL6 IL5 IL15 IL10
33
Rheumatoid arthritis 36
12.09 IL6 IL1A IL17A IL15 CXCL8 CCL5
34
MAPK Pathway 70
Show member pathways
 12.08 IL5 IL1R1 IL1A IL13
35
Senescence and Autophagy in Cancer 1
12.05 IL6 IL1A CXCL8 CCL3 BMP2
36
TNF signaling pathway 36
12.03 IL6 IL15 CCL5 CCL2
37
Hematopoietic cell lineage 36
12.02 IL7 IL6 IL5 IL1R1 IL1A
38
Innate Lymphoid Cell Differentiation Pathways 64
12 IL7 IL5 IL1R1 IL17A IL15 IL13
39
Amoebiasis 36
11.99 IL6 IL1R1 IL10 CXCL8
40
AGE-RAGE signaling pathway in diabetic complications 36
11.97 IL6 IL1A CXCL8 CCL2
41
Glucocorticoid receptor regulatory network 1
11.88 IL6 IL5 IL13 CXCL8
42
Lung fibrosis 1
11.86 IL6 IL5 IL13 CXCL8 CCL5 CCL4
43
Pertussis 36
11.85 IL6 IL1A IL10 CXCL8
44
Th1 Differentiation Pathway 64
Show member pathways
 11.78 IL6 IL17A IL10
45
Interleukin-10 signaling 65
11.76 IL6 IL1R1 IL1A IL13 IL10 CXCL8
46
IgA-Producing B Cells in the Intestine 64
11.72 IL6 IL5 IL10
47
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.7 IL6 IL1A CXCL8
48
IL4-mediated signaling events 1
11.69 IL5 IL10 CCL11
49
Malaria 36
11.65 IL6 IL10 CXCL8 CCL2
50
Th2 Differentiation Pathway 64
11.61 IL5 IL13 IL10 CCL11
Sources

GO Terms for Radiculopathy

About this section

Cellular components related to Radiculopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.89 TAC1 IL7 IL6 IL5 IL1A IL17A
2 extracellular region GO:0005576 9.6 TAC1 PENK IL7 IL6 IL5 IL1R1

Biological processes related to Radiculopathy according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.28 PENK IL7 IL6 IL5 IL1R1 IL15
2 G protein-coupled receptor signaling pathway GO:0007186 10.25 TAC1 PENK CXCL8 CCL5 CCL4 CCL3
3 positive regulation of gene expression GO:0010628 10.13 IL7 IL6 IL1A IL13 CXCL8 CCL3
4 negative regulation of cell proliferation GO:0008285 10.09 IL6 IL1A IL10 CXCL8 BMP2
5 positive regulation of GTPase activity GO:0043547 10.07 CCL5 CCL4 CCL3 CCL2 CCL11
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.03 CCL5 CCL4 CCL3 CCL2 CCL11 BMP2
7 cytokine-mediated signaling pathway GO:0019221 10.03 IL7 IL6 IL5 IL1R1 IL1A IL17A
8 cellular response to lipopolysaccharide GO:0071222 10.01 IL6 IL1A IL10 CXCL8 CCL2
9 chemotaxis GO:0006935 10.01 CXCL8 CCL5 CCL4 CCL3 CCL2 CCL11
10 cell-cell signaling GO:0007267 10.01 TAC1 IL7 IL17A IL15 CCL5 CCL4
11 positive regulation of cell migration GO:0030335 10 CCL5 CCL3 CCL11 BMP2
12 cellular response to tumor necrosis factor GO:0071356 9.99 CXCL8 CCL5 CCL4 CCL3 CCL2 CCL11
13 response to lipopolysaccharide GO:0032496 9.98 TAC1 PENK IL13 IL10
14 cellular response to interferon-gamma GO:0071346 9.95 CCL5 CCL4 CCL3 CCL2 CCL11
15 neutrophil chemotaxis GO:0030593 9.95 CXCL8 CCL5 CCL4 CCL3 CCL2 CCL11
16 response to toxic substance GO:0009636 9.94 PENK CCL5 CCL4 CCL3
17 positive regulation of tumor necrosis factor production GO:0032760 9.93 IL6 IL1A IL17A CCL3
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.93 IL6 IL15 IL13 CCL5
19 chemokine-mediated signaling pathway GO:0070098 9.93 CXCL8 CCL5 CCL4 CCL3 CCL2 CCL11
20 cellular response to organic cyclic compound GO:0071407 9.92 CCL5 CCL3 CCL2 BMP2
21 humoral immune response GO:0006959 9.89 IL7 IL6 IFNA1 CCL2
22 lymphocyte chemotaxis GO:0048247 9.89 CCL5 CCL4 CCL3 CCL2 CCL11
23 cell chemotaxis GO:0060326 9.88 CCL5 CCL3 CCL2
24 positive regulation of endothelial cell proliferation GO:0001938 9.87 IL10 CCL11 BMP2
25 positive regulation of T cell proliferation GO:0042102 9.87 IL6 IL15 CCL5
26 positive regulation of JAK-STAT cascade GO:0046427 9.87 IL6 IL5 IL10 CCL5
27 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 IL6 IL13 CCL5
28 positive regulation of interleukin-1 beta production GO:0032731 9.86 IL6 IL17A CCL3
29 sensory perception of pain GO:0019233 9.86 TAC1 PENK CCL2
30 positive regulation of cytokine production GO:0001819 9.85 IL1A IL15 IL10
31 positive regulation of B cell proliferation GO:0030890 9.84 IL7 IL5 IL13
32 protein kinase B signaling GO:0043491 9.84 CCL5 CCL3 CCL2
33 cellular response to fibroblast growth factor stimulus GO:0044344 9.83 CXCL8 CCL5 CCL2
34 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 CCL5 CCL3 CCL2
35 positive regulation of immunoglobulin production GO:0002639 9.83 IL6 IL5 IL13 IL10
36 immune response GO:0006955 9.83 IL7 IL6 IL5 IL1R1 IL1A IL17A
37 positive regulation of calcium ion transport GO:0051928 9.82 CCL5 CCL4 CCL3
38 monocyte chemotaxis GO:0002548 9.8 IL6 CCL5 CCL4 CCL3 CCL2 CCL11
39 cellular response to interleukin-1 GO:0071347 9.8 IL17A CXCL8 CCL5 CCL4 CCL3 CCL2
40 macrophage chemotaxis GO:0048246 9.79 CCL5 CCL3 CCL2
41 negative regulation by host of viral transcription GO:0043922 9.78 CCL5 CCL4 CCL3
42 neutrophil activation GO:0042119 9.77 IL15 CXCL8 CCL5
43 eosinophil chemotaxis GO:0048245 9.77 CCL5 CCL4 CCL3 CCL2 CCL11
44 positive regulation of natural killer cell chemotaxis GO:2000503 9.75 CCL5 CCL4 CCL3
45 response to molecule of bacterial origin GO:0002237 9.7 IL10 CXCL8
46 astrocyte cell migration GO:0043615 9.67 CCL3 CCL2
47 positive regulation of cellular biosynthetic process GO:0031328 9.66 CXCL8 CCL5
48 inflammatory response GO:0006954 9.5 TAC1 IL6 IL5 IL1R1 IL1A IL17A

Molecular functions related to Radiculopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.8 IL7 IL6 IL5 IL10 BMP2
2 cytokine receptor binding GO:0005126 9.56 IL7 IL15 IL13 IFNA1
3 CCR chemokine receptor binding GO:0048020 9.55 CCL5 CCL4 CCL3 CCL2 CCL11
4 CCR5 chemokine receptor binding GO:0031730 9.54 CCL5 CCL4 CCL3
5 cytokine activity GO:0005125 9.53 IL7 IL6 IL5 IL1A IL17A IL15
6 CCR1 chemokine receptor binding GO:0031726 9.5 CCL5 CCL4 CCL3
7 phospholipase activator activity GO:0016004 9.43 CCL5 CCL3
8 chemokine activity GO:0008009 9.43 CXCL8 CCL5 CCL4 CCL3 CCL2 CCL11
Sources

Sources for Radiculopathy

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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