RD
MCID: RDN004
MIFTS: 12

Radin Blood Group Antigen (RD)

Categories: Blood diseases, Genetic diseases

Aliases & Classifications for Radin Blood Group Antigen

MalaCards integrated aliases for Radin Blood Group Antigen:

Name: Radin Blood Group Antigen 57
Rd 57 17
Blood Group--Radin Antigen 57

Classifications:



External Ids:

OMIM® 57 111620
MedGen 41 C1862204

Summaries for Radin Blood Group Antigen

OMIM® : 57 Radin is a rare red cell antigen discovered by Rausen et al. (1967) in 5 families with varying ethnic backgrounds. It has been shown to cause mild to moderate hemolytic disease of the newborn in some cases. The Radin antigen is determined by a polymorphism in the ERMAP gene (609017.0003) and thus is a member of the blood group Scianna (Wagner et al., 2003). Radin has alternatively been labeled Sc4 to reflect this relationship. Harvey et al. (1983) estimated the frequency of the Radin antigen among Europeans to be 0.04% to 0.66% with the highest frequencies occurring among Swedes and Danes. (111620) (Updated 05-Mar-2021)

MalaCards based summary : Radin Blood Group Antigen, is also known as rd. An important gene associated with Radin Blood Group Antigen is ERMAP (Erythroblast Membrane Associated Protein (Scianna Blood Group)). Related phenotype is abnormal immunoglobulin level.

Related Diseases for Radin Blood Group Antigen

Symptoms & Phenotypes for Radin Blood Group Antigen

Human phenotypes related to Radin Blood Group Antigen:

31
# Description HPO Frequency HPO Source Accession
1 abnormal immunoglobulin level 31 HP:0010701

Clinical features from OMIM®:

111620 (Updated 05-Mar-2021)

Drugs & Therapeutics for Radin Blood Group Antigen

Search Clinical Trials , NIH Clinical Center for Radin Blood Group Antigen

Genetic Tests for Radin Blood Group Antigen

Anatomical Context for Radin Blood Group Antigen

Publications for Radin Blood Group Antigen

Articles related to Radin Blood Group Antigen:

# Title Authors PMID Year
1
Scianna antigens including Rd are expressed by ERMAP. 6 57
12393480 2003
2
The position of the Radin blood group locus in relation to other chromosome l loci. 57
6459052 1980
3
Genetic linkage between the Radin and Rh blood group loci. 57
118583 1979
4
A "new" infrequent red cell antigen, Rd (radin). 57
6069618 1967

Variations for Radin Blood Group Antigen

ClinVar genetic disease variations for Radin Blood Group Antigen:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 ERMAP NM_001017922.2(ERMAP):c.178C>G (p.Pro60Ala) SNV Affects 1917 rs56136737 1:43296531-43296531 1:42830860-42830860

Expression for Radin Blood Group Antigen

Search GEO for disease gene expression data for Radin Blood Group Antigen.

Pathways for Radin Blood Group Antigen

GO Terms for Radin Blood Group Antigen

Sources for Radin Blood Group Antigen

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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