MCID: RGW001
MIFTS: 14

Ragweed Sensitivity

Aliases & Classifications for Ragweed Sensitivity

MalaCards integrated aliases for Ragweed Sensitivity:

Name: Ragweed Sensitivity 57 13

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant


HPO:

31
ragweed sensitivity:
Inheritance autosomal dominant inheritance


External Ids:

OMIM® 57 179450
MedGen 41 C1867394
SNOMED-CT via HPO 68 263681008 386661006 50177009

Summaries for Ragweed Sensitivity

MalaCards based summary : Ragweed Sensitivity An important gene associated with Ragweed Sensitivity is RWS (Ragweed Sensitivity). The drugs Histamine and Levocetirizine have been mentioned in the context of this disorder. Related phenotypes are fever and abnormality of the immune system

More information from OMIM: 179450

Related Diseases for Ragweed Sensitivity

Symptoms & Phenotypes for Ragweed Sensitivity

Human phenotypes related to Ragweed Sensitivity:

31
# Description HPO Frequency HPO Source Accession
1 fever 31 HP:0001945
2 abnormality of the immune system 31 HP:0002715

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Immunology:
ragweed hay fever
hla linkage

Clinical features from OMIM®:

179450 (Updated 05-Apr-2021)

Drugs & Therapeutics for Ragweed Sensitivity

Drugs for Ragweed Sensitivity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
2
Levocetirizine Approved Phase 4 130018-77-8 1549000
3
Montelukast Approved Phase 4 158966-92-8 5281040
4 Neurotransmitter Agents Phase 4
5 Histamine Antagonists Phase 4
6 Histamine H1 Antagonists, Non-Sedating Phase 4
7
Histamine Phosphate Phase 4 51-74-1 65513
8 Histamine H1 Antagonists Phase 4
9 Anti-Asthmatic Agents Phase 4
10 Respiratory System Agents Phase 4
11 Hormone Antagonists Phase 4
12 Leukotriene Antagonists Phase 4
13 Hormones Phase 4
14
Cetirizine Approved Phase 3 83881-51-0 2678
15 Anti-Allergic Agents Phase 2
16 Pharmaceutical Solutions Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Double-blind, Three Parallel Randomized Groups, Therapeutic Confirmatory Clinical Trial to Compare the Efficacy of Oral Levocetirizine 5 mg and Montelukast 10 mg to Placebo in Reducing Symptoms of Seasonal Allergic Rhinitis (SAR) in Ragweed Sensitive Subjects Exposed to Ragweed Pollen in an Environmental Exposure Unit (EEU) Completed NCT00295022 Phase 4 Placebo;Montelukast;Levocetirizine
2 Double-blind, 3 Parallel Randomized Groups, Therapeutic Confirmatory. Clinical Trial to Compare the Efficacy of Levocetirizine 5 mg and Montelukast 10 mg to Placebo in Reducing SAR Symptoms in Ragweed Sensitive Subjects in an EEC. Completed NCT00315523 Phase 3 Levocetirizine
3 Trial to Compare the Efficacy of Levocetirizine and Cetirizine in Reducing Symptoms of Seasonal Allergic Rhinitis in Ragweed Sensitive Subjects Exposed to Pollen Challenge in an Environmental Exposure Unit (EEU). Completed NCT00544388 Phase 3 levocetirizine dihydrochloride
4 Double Blind, Double-dummy, Five Parallel Groups, Randomized, Exploratory Clinical Trial to Compare the Efficacy of Single Dose of Levocetirizine 2.5 mg Oral Drops (5 mg/mL), Levocetirizine 5 mg Oral Tablets, Cetirizine 5 mg Oral Drops (10 mg/mL) and Cetirizine 10 mg Oral Tablets to Placebo in Reducing Symptoms of Seasonal Allergic Rhinitis (SAR) in Ragweed Sensitive Subjects Exposed to Ragweed Pollen in an Environmental Exposure Unit (EEU) Completed NCT00291642 Phase 2 Placebo drops;Placebo tablets matching to levocetirizine;Placebo tablets matching to cetirizine;Levocetirizine drops;Levocetirizine tablets;Cetirizine drops;Cetirizine tablets
5 Safety and Efficacy of AL-53817 Nasal Spray Solution in Ragweed Sensitive Subjects in an Environmental Exposure Chamber (EEC) Completed NCT01454505 Phase 1 AL-53817 nasal spray solution

Search NIH Clinical Center for Ragweed Sensitivity

Genetic Tests for Ragweed Sensitivity

Anatomical Context for Ragweed Sensitivity

Publications for Ragweed Sensitivity

Articles related to Ragweed Sensitivity:

(show all 17)
# Title Authors PMID Year
1
Ragweed sensitivity: segregation analysis and linkage to HLA-B. 61 57
752497 1978
2
Maternal inheritance of atopic IgE responsiveness on chromosome 11q. 57
1353553 1992
3
Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. 57
2566826 1989
4
HL-A, immune-response genes, and disease. 57
4134154 1974
5
Genetic mapping of Ir locus in man: linkage to second locus of HL-A. 57
4833283 1974
6
Association of the HL-A7 cross-reacting group with a specific reaginic antibody response in allergic man. 57
4685040 1973
7
Ragweed hay fever: genetic control and linkage to HL-A haplotypes. 57
4637806 1972
8
Fluticasone nasal spray and the combination of loratadine and montelukast in seasonal allergic rhinitis. 61
12759270 2003
9
Allergen sensitivity and asthma severity at an inner city asthma center. 61
12699212 2003
10
Comparison of the in-vivo and in-vitro response to ragweed immunotherapy in children and adults with ragweed-induced rhinitis. 61
2253080 1990
11
T cell receptor variable gene expression: analysis in ragweed-sensitive patients during allergen exposure. 61
2354872 1990
12
Immunochemical quantitation, size distribution, and cross-reactivity of lepidoptera (moth) aeroallergens in southeastern Minnesota. 61
2455744 1988
13
The pharmacological profile and initial clinical evaluation of tiacrilast (Ro 22-3747): a new antiallergic agent. 61
2428219 1986
14
Effector cell heterogeneity in immediate hypersensitivity reactions. 61
6201251 1983
15
Controlled evaluation of allergoid in the immunotherapy of ragweed hay fever. 61
6181113 1982
16
Effect of environmental exposure on bronchial sensitivity to antigen. 61
447407 1979
17
Effect of ragweed hyperimmune human gamma globulin on in vivo and in vitro parameters of ragweed sensitivity. 61
57128 1976

Variations for Ragweed Sensitivity

Expression for Ragweed Sensitivity

Search GEO for disease gene expression data for Ragweed Sensitivity.

Pathways for Ragweed Sensitivity

GO Terms for Ragweed Sensitivity

Sources for Ragweed Sensitivity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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