Rare Adenocarcinoma of the Breast disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: RRD004 MIFTS: 27	Rare Adenocarcinoma of the Breast Categories: Cancer diseases, Rare diseases, Reproductive diseases
Genes Variations Tissues Related diseases Pathways Expand all tables

Sources

Aliases & Classifications for Rare Adenocarcinoma of the Breast

MalaCards integrated aliases for Rare Adenocarcinoma of the Breast:

Name: Rare Adenocarcinoma of the Breast ⁵² ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Malignant neoplasm of breast

Malignant neoplasm: Axillary tail of breast

Malignant neoplasm: Central portion of breast

Malignant neoplasm: Lower-inner quadrant of breast

Malignant neoplasm: Lower-outer quadrant of breast

Malignant neoplasm: Nipple and areola

Malignant neoplasm: Overlapping lesion of breast

Malignant neoplasm: Upper-inner quadrant of breast

Malignant neoplasm: Upper-outer quadrant of breast

Orphanet: ⁵⁸

Rare gynaecological and obstetric diseases

External Ids:

ICD10 via Orphanet ³³ C50.0 C50.1 C50.2 more

UMLS via Orphanet ⁷² C0858252

Orphanet ⁵⁸ ORPHA213528

Sources

Summaries for Rare Adenocarcinoma of the Breast

MalaCards based summary : Rare Adenocarcinoma of the Breast is related to ovarian clear cell adenofibroma and hyperplastic polyposis syndrome. An important gene associated with Rare Adenocarcinoma of the Breast is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Parkinson disease and Endometrial cancer. Affiliated tissues include breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Sources

Related Diseases for Rare Adenocarcinoma of the Breast

Diseases in the Breast Adenocarcinoma family:

Rare Adenocarcinoma of the Breast

Diseases related to Rare Adenocarcinoma of the Breast via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)

#	Related Disease	Score	Top Affiliating Genes
1	ovarian clear cell adenofibroma	10.1	PIK3CA KRAS
2	hyperplastic polyposis syndrome	10.1	TP53 KRAS
3	adenosquamous lung carcinoma	10.1	PIK3CA KRAS
4	gallbladder benign neoplasm	10.1	TP53 KRAS
5	wolffian duct adenocarcinoma	10.1	TP53 KRAS
6	liver angiosarcoma	10.1	TP53 KRAS
7	angiosarcoma	10.1	TP53 KRAS
8	biliary tract benign neoplasm	10.1	TP53 KRAS
9	tumor of exocrine pancreas	10.1	TP53 KRAS
10	endosalpingiosis	10.1	TP53 KRAS
11	embryonal rhabdomyosarcoma	10.1	TP53 KRAS
12	appendix disease	10.1	TP53 KRAS
13	papillary adenoma	10.1	TP53 KRAS
14	appendix cancer	10.1	TP53 KRAS
15	oculoectodermal syndrome	10.1	PIK3CA KRAS
16	rare carcinoma of pancreas	10.1	TP53 KRAS
17	nasal cavity cancer	10.1	TP53 KRAS
18	skin papilloma	10.1	TP53 KRAS
19	duodenum cancer	10.1	TP53 KRAS
20	cystadenocarcinoma	10.1	TP53 PIK3CA
21	mature teratoma	10.1	TP53 KRAS
22	papillary serous adenocarcinoma	10.1	TP53 KRAS
23	rare head and neck tumor	10.1	TP53 PIK3CA
24	villous adenoma	10.1	TP53 KRAS
25	respiratory system benign neoplasm	10.1	TP53 KRAS
26	pseudomyxoma peritonei	10.1	TP53 KRAS
27	signet ring cell adenocarcinoma	10.1	TP53 KRAS
28	parameningeal embryonal rhabdomyosarcoma	10.1	TP53 PIK3CA
29	cystic teratoma	10.1	TP53 KRAS
30	pulmonary blastoma	10.1	TP53 KRAS
31	ovarian carcinosarcoma	10.1	TP53 PIK3CA
32	lipomatosis	10.1	PIK3CA KRAS
33	breast sarcoma	10.1	TP53 PIK3CA
34	vulva squamous cell carcinoma	10.1	TP53 PIK3CA
35	barrett's adenocarcinoma	10.1	TP53 KRAS
36	malignant spiradenoma	10.1	TP53 PIK3CA
37	uterine adnexa cancer	10.1	TP53 PIK3CA
38	lung adenoma	10.1	TP53 KRAS
39	acanthoma	10.1	TP53 PIK3CA
40	schimmelpenning-feuerstein-mims syndrome	10.1	PIK3CA KRAS
41	anal squamous cell carcinoma	10.1	TP53 PIK3CA
42	vulvar disease	10.1	TP53 PIK3CA
43	hypertrophy of breast	10.1	TP53 PIK3CA
44	cervical adenocarcinoma	10.1	TP53 KRAS
45	epithelial-myoepithelial carcinoma	10.0	TP53 PIK3CA
46	uterine benign neoplasm	10.0	TP53 KRAS
47	myoepithelial carcinoma	10.0	TP53 PIK3CA
48	reproductive organ benign neoplasm	10.0	TP53 KRAS
49	colonic benign neoplasm	10.0	TP53 KRAS
50	endocervical carcinoma	10.0	TP53 PIK3CA

Graphical network of the top 20 diseases related to Rare Adenocarcinoma of the Breast:

Sources

Symptoms & Phenotypes for Rare Adenocarcinoma of the Breast

GenomeRNAi Phenotypes related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

²⁶ (show all 19)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-10	9.8	RB1CC1
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-12	9.8	TP53
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	9.8	KRAS RB1CC1 TP53
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-132	9.8	TP53
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	9.8	TP53
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-171	9.8	RB1CC1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-179	9.8	RB1CC1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-184	9.8	TP53
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	9.8	TP53
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	9.8	TP53
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-20	9.8	TP53
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-22	9.8	KRAS
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-35	9.8	TP53
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-37	9.8	RB1CC1
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-39	9.8	TP53
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-59	9.8	RB1CC1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-60	9.8	PIK3CA
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-62	9.8	TP53
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.8	KRAS

MGI Mouse Phenotypes related to Rare Adenocarcinoma of the Breast:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle	MP:0005369	9.46	KRAS PIK3CA RB1CC1 TP53
2	no phenotypic analysis	MP:0003012	9.26	KRAS PIK3CA RB1CC1 TP53
3	pigmentation	MP:0001186	8.8	KRAS RB1CC1 TP53

Sources

Drugs & Therapeutics for Rare Adenocarcinoma of the Breast

Search Clinical Trials , NIH Clinical Center for Rare Adenocarcinoma of the Breast

Sources

Genetic Tests for Rare Adenocarcinoma of the Breast

Sources

Anatomical Context for Rare Adenocarcinoma of the Breast

MalaCards organs/tissues related to Rare Adenocarcinoma of the Breast:

⁴⁰

Breast

Sources

Publications for Rare Adenocarcinoma of the Breast

Sources

Genes for Rare Adenocarcinoma of the Breast

Genes related to Rare Adenocarcinoma of the Breast (5 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	400	Pathogenic ⁶
2	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	400	Pathogenic ⁶ Pathogenic/Likely pathogenic ⁶
3	RB1CC1	RB1 Inducible Coiled-Coil 1	Protein Coding	400	Pathogenic ⁶
4	SLC22A18	Solute Carrier Family 22 Member 18	Protein Coding	400	Pathogenic ⁶
5	TP53	Tumor Protein P53	Protein Coding	400	Pathogenic/Likely pathogenic ⁶

Sources

Variations for Rare Adenocarcinoma of the Breast

ClinVar genetic disease variations for Rare Adenocarcinoma of the Breast:

⁶ (show all 11) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	RB1CC1	nsv1067860	deletion	Pathogenic	3976		8:53536328-53598019	8:52623768-52685459
2	RB1CC1	nsv1067861	deletion	Pathogenic	3977		8:53537321-53574220	8:52624761-52661660
3	SLC22A18	NM_002555.5(SLC22A18):c.864_865insNC_000011.10:g.2919738_2919848	insertion	Pathogenic	6976
4	KRAS	NM_033360.4(KRAS):c.38G>A (p.Gly13Asp)	SNV	Pathogenic	12580	rs112445441	12:25398281-25398281	12:25245347-25245347
5	PIK3CA	NM_006218.4(PIK3CA):c.3140A>G (p.His1047Arg)	SNV	Pathogenic	13652	rs121913279	3:178952085-178952085	3:179234297-179234297
6	PIK3CA	NM_006218.4(PIK3CA):c.3140A>T (p.His1047Leu)	SNV	Pathogenic	13653	rs121913279	3:178952085-178952085	3:179234297-179234297
7	PIK3CA	NM_006218.4(PIK3CA):c.1633G>A (p.Glu545Lys)	SNV	Pathogenic	13655	rs104886003	3:178936091-178936091	3:179218303-179218303
8	TP53	NM_000546.6(TP53):c.451C>T (p.Pro151Ser)	SNV	Pathogenic/Likely pathogenic	12370	rs28934874	17:7578479-7578479	17:7675161-7675161
9	PIK3CA	NM_006218.4(PIK3CA):c.1636C>G (p.Gln546Glu)	SNV	Pathogenic/Likely pathogenic	13654	rs121913286	3:178936094-178936094	3:179218306-179218306
10	TP53	NM_001126112.2(TP53):c.451C>A (p.Pro151Thr)	SNV	Likely pathogenic	12369	rs28934874	17:7578479-7578479	17:7675161-7675161
11	AKT1	NM_005163.2(AKT1):c.49G>A (p.Glu17Lys)	SNV	Uncertain significance	13983	rs121434592	14:105246551-105246551	14:104780214-104780214

Sources

Expression for Rare Adenocarcinoma of the Breast

Search GEO for disease gene expression data for Rare Adenocarcinoma of the Breast.

Sources

Pathways for Rare Adenocarcinoma of the Breast

Pathways related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

(show all 40)

#	Super pathways	Score	Top Affiliating Genes
1	Parkinson disease ³⁶ Show member pathways Alzheimer disease ³⁶ Huntington disease ³⁶	12.79	TP53 RB1CC1 PIK3CA KRAS
2	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	12.6	TP53 PIK3CA KRAS
3	Pathways in cancer ³⁶	12.57	TP53 PIK3CA KRAS
4	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.48	TP53 PIK3CA KRAS
5	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.45	TP53 PIK3CA KRAS
6	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁵ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.43	TP53 PIK3CA KRAS
7	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁶ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathways ⁶⁴	12.42	TP53 PIK3CA KRAS
8	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.38	TP53 PIK3CA KRAS
9	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.34	TP53 PIK3CA KRAS
10	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.31	TP53 PIK3CA KRAS
11	MicroRNAs in cancer ³⁶	12.24	TP53 PIK3CA KRAS
12	mTOR signaling pathway (KEGG) ³⁶ Show member pathways mTOR Signaling ⁶⁴	12.21	TP53 PIK3CA KRAS
13	VEGF Signaling ⁶⁶ Show member pathways EGFR Signaling Pathway ⁶⁶ TGF-beta Signaling Pathway ⁶⁶ VEGF Signaling Pathway ⁶⁰	12.2	TP53 PIK3CA KRAS
14	Apoptosis Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ NF-kappaB Pathway ⁷⁰	12.13	TP53 PIK3CA KRAS
15	Human T-cell leukemia virus 1 infection ³⁶	12.03	TP53 PIK3CA KRAS
16	Proteoglycans in cancer ³⁶	11.98	TP53 PIK3CA KRAS
17	Viral carcinogenesis ³⁶	11.96	TP53 PIK3CA KRAS
18	MAPK Signaling: Mitogens ⁶⁴ Show member pathways Akt Signaling Pathway ⁶⁴	11.94	TP53 PIK3CA KRAS
19	Jak Stat Signaling Pathway ⁶⁶ Show member pathways Commom Cytokine Receptor G Chain Siganaling Pathway ⁶⁶	11.89	PIK3CA KRAS
20	mTOR Pathway ⁷⁰ Show member pathways Insulin Pathway ⁷⁰ TGF-beta Pathway ⁷⁰	11.84	TP53 PIK3CA KRAS
21	Cellular senescence (KEGG) ³⁶	11.8	TP53 PIK3CA KRAS
22	Autophagy - animal ³⁶	11.72	RB1CC1 PIK3CA KRAS
23	FGFR1 mutant receptor activation ⁶⁵ Show member pathways Signaling by cytosolic FGFR1 fusion mutants ⁶⁵ Signaling by FGFR1 in disease ⁶⁵ Signaling by plasma membrane FGFR1 fusions ⁶⁵	11.64	PIK3CA KRAS
24	Thyroid hormone signaling pathway ³⁶	11.63	TP53 PIK3CA KRAS
25	VEGF Pathway (Tocris) ⁶⁰ Show member pathways VEGF Pathway ⁷⁰	11.6	PIK3CA KRAS
26	MAPK Signaling: Oxidative Stress ⁶⁴	11.57	TP53 KRAS
27	Sphingolipid signaling pathway ³⁶	11.57	TP53 PIK3CA KRAS
28	Platinum drug resistance ³⁶	11.53	TP53 PIK3CA
29	Bladder cancer ³⁶ ¹	11.53	TP53 KRAS
30	Mitophagy - animal ³⁶	11.49	TP53 KRAS
31	DNA Damage Response (only ATM dependent) ¹	11.49	TP53 PIK3CA KRAS
32	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.47	TP53 PIK3CA
33	p75(NTR)-mediated signaling ¹ Show member pathways Ceramide signalling ⁶⁵ NFG and proNGF binds to p75NTR ⁶⁵	11.47	TP53 PIK3CA
34	GnRH secretion ³⁶	11.45	PIK3CA KRAS
35	Copper homeostasis ¹	11.36	TP53 PIK3CA
36	Central carbon metabolism in cancer ³⁶	11.18	TP53 PIK3CA KRAS
37	Aldosterone-regulated sodium reabsorption ³⁶	11.16	PIK3CA KRAS
38	Longevity regulating pathway ³⁶ Show member pathways Longevity regulating pathway - multiple species ³⁶	11.1	TP53 RB1CC1 PIK3CA KRAS
39	G-protein signaling_K-RAS regulation pathway ²²	10.98	PIK3CA KRAS
40	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities ¹	10.61	RB1CC1 PIK3CA KRAS

Sources

GO Terms for Rare Adenocarcinoma of the Breast

Biological processes related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Ras protein signal transduction	GO:0007265	9.16	TP53 KRAS
2	cytokine-mediated signaling pathway	GO:0019221	9.13	TP53 PIK3CA KRAS
3	liver development	GO:0001889	8.8	RB1CC1 PIK3CA KRAS

Sources

Sources for Rare Adenocarcinoma of the Breast

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia