Rare Adenocarcinoma of the Breast disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: RRD004 MIFTS: 30	Rare Adenocarcinoma of the Breast Categories: Rare diseases, Reproductive diseases, Cancer diseases
Genes Variations Related diseases Pathways Download Expand all tables

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Aliases & Classifications for Rare Adenocarcinoma of the Breast

MalaCards integrated aliases for Rare Adenocarcinoma of the Breast:

Name: Rare Adenocarcinoma of the Breast ⁵³ ⁵⁹

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Neoplasms

Malignant neoplasm of breast

Malignant neoplasm: Axillary tail of breast

Malignant neoplasm: Central portion of breast

Malignant neoplasm: Lower-inner quadrant of breast

Malignant neoplasm: Lower-outer quadrant of breast

Malignant neoplasm: Nipple and areola

Malignant neoplasm: Overlapping lesion of breast

Malignant neoplasm: Upper-inner quadrant of breast

Malignant neoplasm: Upper-outer quadrant of breast

Orphanet: ⁵⁹

Rare gynaecological and obstetric diseases

External Ids:

Orphanet ⁵⁹ ORPHA213528

ICD10 via Orphanet ³⁴ C50.0 C50.1 C50.2 more

UMLS via Orphanet ⁷⁴ C0858252

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Summaries for Rare Adenocarcinoma of the Breast

MalaCards based summary : Rare Adenocarcinoma of the Breast is related to hidradenoma and proteus syndrome. An important gene associated with Rare Adenocarcinoma of the Breast is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Response to elevated platelet cytosolic Ca2+. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Rare Adenocarcinoma of the Breast

Diseases in the Breast Adenocarcinoma family:

Rare Adenocarcinoma of the Breast

Diseases related to Rare Adenocarcinoma of the Breast via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)

#	Related Disease	Score	Top Affiliating Genes
1	hidradenoma	10.4	AKT1 PIK3CA
2	proteus syndrome	10.3	AKT1 PIK3CA
3	apocrine adenoma	10.3	KRAS PIK3CA
4	aggressive digital papillary adenocarcinoma	10.3	KRAS PIK3CA
5	undifferentiated pleomorphic sarcoma	10.2	KRAS PIK3CA
6	lung adenoid cystic carcinoma	10.2	KRAS PIK3CA
7	nevus, epidermal	10.2	KRAS PIK3CA
8	acneiform dermatitis	10.2	KRAS PIK3CA
9	adenosquamous cell lung carcinoma	10.2	KRAS PIK3CA
10	adult hepatocellular carcinoma	10.0	PIK3CA TP53
11	malignant spiradenoma	10.0	PIK3CA TP53
12	breast squamous cell carcinoma	10.0	PIK3CA TP53
13	esophagus adenocarcinoma	10.0	PIK3CA TP53
14	prostate squamous cell carcinoma	10.0	PIK3CA TP53
15	brain stem glioma	9.9	PIK3CA TP53
16	bladder squamous cell carcinoma	9.9	PIK3CA TP53
17	hyperplastic polyposis syndrome	9.8	KRAS TP53
18	anaplastic thyroid cancer	9.8	PIK3CA TP53
19	mutyh-associated polyposis	9.8	KRAS TP53
20	nasal cavity adenocarcinoma	9.8	KRAS TP53
21	mature teratoma	9.8	KRAS TP53
22	pulmonary blastoma	9.7	KRAS TP53
23	biliary papillomatosis	9.7	KRAS TP53
24	pharynx cancer	9.7	AKT1 TP53
25	mixed cell type cancer	9.7	KRAS TP53
26	ovary adenocarcinoma	9.7	KRAS TP53
27	connective tissue cancer	9.7	AKT1 TP53
28	biliary tract neoplasm	9.7	KRAS TP53
29	liver angiosarcoma	9.7	KRAS TP53
30	pseudomyxoma peritonei	9.7	KRAS TP53
31	integumentary system cancer	9.7	AKT1 TP53
32	barrett's adenocarcinoma	9.7	KRAS TP53
33	bile duct adenocarcinoma	9.7	KRAS TP53
34	gastrointestinal system benign neoplasm	9.6	KRAS TP53
35	intestinal benign neoplasm	9.6	KRAS TP53
36	peripheral nervous system neoplasm	9.6	AKT1 TP53
37	lung benign neoplasm	9.6	KRAS TP53
38	autonomic nervous system neoplasm	9.6	AKT1 TP53
39	adenosquamous carcinoma	9.6	KRAS TP53
40	anal squamous cell carcinoma	9.5	AKT1 PIK3CA TP53
41	serous cystadenocarcinoma	9.5	AKT1 PIK3CA TP53
42	estrogen-receptor positive breast cancer	9.4	AKT1 PIK3CA TP53
43	cystadenocarcinoma	9.4	AKT1 PIK3CA TP53
44	suppression of tumorigenicity 12	9.4	AKT1 PIK3CA TP53
45	cell type benign neoplasm	9.4	KRAS TP53
46	ductal carcinoma in situ	9.4	AKT1 TP53
47	small cell cancer of the lung	9.4	AKT1 PIK3CA TP53
48	glioblastoma multiforme	9.4	AKT1 PIK3CA TP53
49	brain cancer	9.4	AKT1 PIK3CA TP53
50	squamous cell carcinoma, head and neck	9.4	AKT1 PIK3CA TP53

Graphical network of the top 20 diseases related to Rare Adenocarcinoma of the Breast:

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Symptoms & Phenotypes for Rare Adenocarcinoma of the Breast

GenomeRNAi Phenotypes related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

²⁶ (show all 24)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.97	KRAS
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	9.97	PIK3CA
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-12	9.97	TP53
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	9.97	RB1CC1 KRAS TP53
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-132	9.97	TP53
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-157	9.97	PIK3CA
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	9.97	PIK3CA
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-166	9.97	PIK3CA
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	9.97	KRAS
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-169	9.97	TP53
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.97	PIK3CA KRAS
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	9.97	TP53
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	9.97	PIK3CA TP53
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-196	9.97	KRAS
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	9.97	RB1CC1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-23	9.97	KRAS
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-35	9.97	TP53
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-37	9.97	RB1CC1
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-39	9.97	TP53
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.97	PIK3CA
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	9.97	PIK3CA RB1CC1 KRAS
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	9.97	KRAS
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.97	KRAS
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-93	9.97	KRAS

MGI Mouse Phenotypes related to Rare Adenocarcinoma of the Breast:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.72	AKT1 KRAS PIK3CA RB1CC1 TP53
2	integument	MP:0010771	9.65	AKT1 KRAS PIK3CA RB1CC1 TP53
3	liver/biliary system	MP:0005370	9.46	AKT1 KRAS RB1CC1 TP53
4	muscle	MP:0005369	9.35	AKT1 KRAS PIK3CA RB1CC1 TP53
5	neoplasm	MP:0002006	8.92	AKT1 KRAS PIK3CA TP53

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Drugs & Therapeutics for Rare Adenocarcinoma of the Breast

Search Clinical Trials , NIH Clinical Center for Rare Adenocarcinoma of the Breast

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Genetic Tests for Rare Adenocarcinoma of the Breast

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Anatomical Context for Rare Adenocarcinoma of the Breast

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Publications for Rare Adenocarcinoma of the Breast

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Genes for Rare Adenocarcinoma of the Breast

Genes related to Rare Adenocarcinoma of the Breast (4 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	425	Pathogenic ⁶ Pathogenic/Likely pathogenic ⁶
2	SLC22A18	Solute Carrier Family 22 Member 18	Protein Coding	400	Pathogenic ⁶
3	RB1CC1	RB1 Inducible Coiled-Coil 1	Protein Coding	400	Pathogenic ⁶
4	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	400	Pathogenic ⁶
5	TP53	Tumor Protein P53	Protein Coding	25	Pathogenic/Likely pathogenic ⁶
6	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	25	Pathogenic/Likely pathogenic ⁶

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Variations for Rare Adenocarcinoma of the Breast

ClinVar genetic disease variations for Rare Adenocarcinoma of the Breast:

⁶

(show all 22)

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	RB1CC1	NG_015833.1: g.34008_95699del61692	deletion	Pathogenic		GRCh38	Chromosome 8, 52623768: 52685459
2	RB1CC1	NG_015833.1: g.34008_95699del61692	deletion	Pathogenic		GRCh37	Chromosome 8, 53536328: 53598019
3	RB1CC1	NG_015833.1: g.57807_94706del36900	deletion	Pathogenic		GRCh38	Chromosome 8, 52624761: 52661660
4	RB1CC1	NG_015833.1: g.57807_94706del36900	deletion	Pathogenic		GRCh37	Chromosome 8, 53537321: 53574220
5	SLC22A18	NM_002555.5(SLC22A18): c.864_865insNC_000011.10: g.2919738_2919848	insertion	Pathogenic
6	TP53	NM_000546.5(TP53): c.451C> A (p.Pro151Thr)	single nucleotide variant	Likely pathogenic	rs28934874	GRCh37	Chromosome 17, 7578479: 7578479
7	TP53	NM_000546.5(TP53): c.451C> A (p.Pro151Thr)	single nucleotide variant	Likely pathogenic	rs28934874	GRCh38	Chromosome 17, 7675161: 7675161
8	TP53	NM_000546.5(TP53): c.451C> T (p.Pro151Ser)	single nucleotide variant	Pathogenic/Likely pathogenic	rs28934874	GRCh37	Chromosome 17, 7578479: 7578479
9	TP53	NM_000546.5(TP53): c.451C> T (p.Pro151Ser)	single nucleotide variant	Pathogenic/Likely pathogenic	rs28934874	GRCh38	Chromosome 17, 7675161: 7675161
10	KRAS	NM_033360.3(KRAS): c.38G> A (p.Gly13Asp)	single nucleotide variant	Pathogenic	rs112445441	GRCh37	Chromosome 12, 25398281: 25398281
11	KRAS	NM_033360.3(KRAS): c.38G> A (p.Gly13Asp)	single nucleotide variant	Pathogenic	rs112445441	GRCh38	Chromosome 12, 25245347: 25245347
12	PIK3CA	NM_006218.3(PIK3CA): c.3140A> G (p.His1047Arg)	single nucleotide variant	Pathogenic	rs121913279	GRCh37	Chromosome 3, 178952085: 178952085
13	PIK3CA	NM_006218.3(PIK3CA): c.3140A> G (p.His1047Arg)	single nucleotide variant	Pathogenic	rs121913279	GRCh38	Chromosome 3, 179234297: 179234297
14	PIK3CA	NM_006218.3(PIK3CA): c.3140A> T (p.His1047Leu)	single nucleotide variant	Pathogenic	rs121913279	GRCh37	Chromosome 3, 178952085: 178952085
15	PIK3CA	NM_006218.3(PIK3CA): c.3140A> T (p.His1047Leu)	single nucleotide variant	Pathogenic	rs121913279	GRCh38	Chromosome 3, 179234297: 179234297
16	PIK3CA	NM_006218.3(PIK3CA): c.1636C> G (p.Gln546Glu)	single nucleotide variant	Pathogenic/Likely pathogenic	rs121913286	GRCh37	Chromosome 3, 178936094: 178936094
17	PIK3CA	NM_006218.3(PIK3CA): c.1636C> G (p.Gln546Glu)	single nucleotide variant	Pathogenic/Likely pathogenic	rs121913286	GRCh38	Chromosome 3, 179218306: 179218306
18	PIK3CA	NM_006218.3(PIK3CA): c.1633G> A (p.Glu545Lys)	single nucleotide variant	Pathogenic/Likely pathogenic	rs104886003	GRCh37	Chromosome 3, 178936091: 178936091
19	PIK3CA	NM_006218.3(PIK3CA): c.1633G> A (p.Glu545Lys)	single nucleotide variant	Pathogenic/Likely pathogenic	rs104886003	GRCh38	Chromosome 3, 179218303: 179218303
20	PIK3CA	NM_006218.3(PIK3CA): c.1633G> A (p.Glu545Lys)	single nucleotide variant	Pathogenic/Likely pathogenic	rs104886003	NCBI36	Chromosome 3, 180418785: 180418785
21	AKT1	NM_005163.2(AKT1): c.49G> A (p.Glu17Lys)	single nucleotide variant	Pathogenic/Likely pathogenic	rs121434592	GRCh37	Chromosome 14, 105246551: 105246551
22	AKT1	NM_005163.2(AKT1): c.49G> A (p.Glu17Lys)	single nucleotide variant	Pathogenic/Likely pathogenic	rs121434592	GRCh38	Chromosome 14, 104780214: 104780214

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Expression for Rare Adenocarcinoma of the Breast

Search GEO for disease gene expression data for Rare Adenocarcinoma of the Breast.

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Pathways for Rare Adenocarcinoma of the Breast

Pathways related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

(show top 50) (show all 110)

#	Super pathways	Score	Top Affiliating Genes
1	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.2	AKT1 KRAS PIK3CA TP53
2	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	13.16	AKT1 KRAS PIK3CA TP53
3	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.83	AKT1 KRAS PIK3CA TP53
4	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.78	AKT1 KRAS PIK3CA TP53
5	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.73	AKT1 KRAS PIK3CA TP53
6	Pathways in cancer ³⁷	12.69	AKT1 KRAS PIK3CA TP53
7	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁷ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathways ⁶⁵ Death Receptor Signaling ⁶⁷	12.66	AKT1 KRAS PIK3CA TP53
8	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.62	AKT1 KRAS PIK3CA TP53
9	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.61	AKT1 KRAS PIK3CA TP53
10	Ras signaling pathway ³⁷ Show member pathways Rap1 signaling pathway ³⁷	12.6	AKT1 KRAS PIK3CA
11	Downstream signaling events of B Cell Receptor (BCR) ⁶⁶ Show member pathways Activation of RAS in B cells ⁶⁶ Signaling by the B Cell Receptor (BCR) ⁶⁶	12.58	AKT1 KRAS PIK3CA TP53
12	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ Neurotrophin signaling pathway ³⁷ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.56	AKT1 KRAS PIK3CA TP53
13	Development Endothelin-1/EDNRA signaling ²² Show member pathways Cytoskeleton remodeling FAK signaling ²² Development Endothelin-1/EDNRA transactivation of EGFR ²² GnRH signaling pathway ³⁷ Inflammatory mediator regulation of TRP channels ³⁷	12.55	AKT1 KRAS PIK3CA
14	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.55	AKT1 KRAS TP53
15	Immune response Fc epsilon RI pathway ²² Show member pathways Fc epsilon RI signaling pathway ³⁷ Fc-epsilon receptor I signaling in mast cells ¹ Immune response BCR pathway ²² VEGF signaling pathway ³⁷	12.47	AKT1 KRAS PIK3CA
16	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.44	AKT1 KRAS PIK3CA TP53
17	Kaposi's sarcoma-associated herpesvirus infection ³⁷ Show member pathways Hepatitis B ³⁷	12.42	AKT1 KRAS PIK3CA TP53
18	MicroRNAs in cancer ³⁷	12.41	KRAS PIK3CA TP53
19	Prolactin Signaling Pathway ¹ ³⁷ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.38	AKT1 KRAS PIK3CA
20	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ¹	12.38	AKT1 KRAS PIK3CA TP53
21	Development FGFR signaling pathway ²² Show member pathways Development FGF-family signaling ²² Development Flt3 signaling ²² FGF Pathway ⁶⁴	12.35	AKT1 KRAS PIK3CA
22	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁷ AMPK Signaling Pathway ⁶⁷	12.34	AKT1 PIK3CA TP53
23	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.33	AKT1 KRAS PIK3CA
24	mTOR signaling pathway (KEGG) ⁶⁵ Show member pathways mTOR signaling pathway ³⁷	12.33	AKT1 KRAS PIK3CA TP53
25	VEGF Pathway (Qiagen) ⁶⁴ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF Family Ligands and Receptor Interactions ⁶⁴	12.31	AKT1 KRAS PIK3CA
26	ErbB signaling pathway ¹ ³⁷ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶¹ Renal cell carcinoma ³⁷ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.31	AKT1 KRAS PIK3CA TP53
27	Phospholipase D signaling pathway ³⁷ Show member pathways Choline metabolism in cancer ³⁷	12.3	AKT1 KRAS PIK3CA
28	Development VEGF signaling via VEGFR2 - generic cascades ²² Show member pathways Development VEGF signaling and activation ²² VEGF - VEGF R2 Signaling Pathways ⁶⁵	12.3	AKT1 KRAS PIK3CA
29	B cell receptor signaling pathway (KEGG) ³⁷ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.28	AKT1 KRAS PIK3CA
30	Apoptosis Pathway ⁷² Show member pathways Akt Pathway ⁷² NF-kappaB Pathway ⁷²	12.26	AKT1 KRAS PIK3CA TP53
31	MET promotes cell motility ⁶⁶ Show member pathways Alpha 6 Beta 4 signaling pathway ¹ Laminin interactions ⁶⁶ MET activates PTK2 signaling ⁶⁶ MET activates RAP1 and RAC1 ⁶⁶ MET activates RAS signaling ⁶⁶ MET interacts with TNS proteins ⁶⁶ MET Receptor Activation ⁶⁶ MET receptor recycling ⁶⁶ Signaling by MET ⁶⁶	12.25	AKT1 KRAS PIK3CA
32	Oocyte meiosis ³⁷ Show member pathways Progesterone-mediated oocyte maturation ³⁷	12.25	AKT1 KRAS PIK3CA
33	HTLV-I infection ³⁷	12.23	AKT1 KRAS PIK3CA TP53
34	B Cell Receptor Signaling Pathway (sino) ⁶⁷ Show member pathways B Cell Receptor Signaling Pathway ⁶⁷	12.22	AKT1 KRAS PIK3CA
35	Signaling by ERBB2 ⁶⁶ Show member pathways Downregulation of ERBB2 signaling ⁶⁶ Downregulation of ERBB2-ERBB3 signaling ⁶⁶ ERBB2 Activates PTK6 Signaling ⁶⁶ ERBB2 Regulates Cell Motility ⁶⁶ GRB2 events in ERBB2 signaling ⁶⁶ GRB7 events in ERBB2 signaling ⁶⁶ PI3K events in ERBB2 signaling ⁶⁶ PI3K events in ERBB4 signaling ⁶⁶ PLCG1 events in ERBB2 signaling ⁶⁶ SHC1 events in ERBB2 signaling ⁶⁶ SHC1 events in ERBB4 signaling ⁶⁶	12.21	AKT1 KRAS PIK3CA
36	Epstein-Barr virus infection ³⁷	12.19	AKT1 PIK3CA TP53
37	Viral carcinogenesis ³⁷	12.19	KRAS PIK3CA TP53
38	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.12	AKT1 KRAS PIK3CA
39	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²² Show member pathways Activation of the AP-1 family of transcription factors ⁶⁶ Immune response Oncostatin M signaling via MAPK in human cells ²² MAPK Cascade ¹ Oncostatin M Signaling Pathway ¹	12.12	AKT1 KRAS TP53
40	Proteoglycans in cancer ³⁷	12.1	AKT1 KRAS PIK3CA TP53
41	Colorectal Cancer Metastasis ⁶⁴	12.09	AKT1 KRAS TP53
42	Integrated Breast Cancer Pathway ¹	12.06	AKT1 KRAS TP53
43	NGF Pathway ⁶⁴ Show member pathways TRKA Signaling ⁶⁴	12.05	AKT1 KRAS TP53
44	Development EGFR signaling via small GTPases ²² Show member pathways Development EGFR signaling via PIP3 ²² Development PDGF signaling via MAPK cascades ²² PDGF Pathway ¹	12.05	AKT1 KRAS PIK3CA
45	Fluid shear stress and atherosclerosis ³⁷	12	AKT1 PIK3CA TP53
46	Signaling pathways regulating pluripotency of stem cells ³⁷	12	AKT1 KRAS PIK3CA
47	FoxO signaling pathway ³⁷ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	11.99	AKT1 KRAS PIK3CA
48	IL-2 Signaling Pathway ¹ Show member pathways IL2-mediated signaling events ¹ IL-5 Signaling Pathway ¹	11.98	AKT1 KRAS PIK3CA
49	mTOR Pathway ⁷² Show member pathways Insulin Pathway ⁷² TGF-beta Pathway ⁷²	11.98	AKT1 KRAS PIK3CA TP53
50	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.97	AKT1 KRAS PIK3CA

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GO Terms for Rare Adenocarcinoma of the Breast

Biological processes related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.69	AKT1 KRAS TP53
2	positive regulation of protein phosphorylation	GO:0001934	9.54	AKT1 KRAS RB1CC1
3	glucose metabolic process	GO:0006006	9.52	AKT1 PIK3CA
4	protein kinase B signaling	GO:0043491	9.49	AKT1 PIK3CA
5	ERBB2 signaling pathway	GO:0038128	9.48	KRAS PIK3CA
6	phosphatidylinositol 3-kinase signaling	GO:0014065	9.46	AKT1 PIK3CA
7	positive regulation of nitric-oxide synthase activity	GO:0051000	9.43	AKT1 KRAS
8	striated muscle cell differentiation	GO:0051146	9.4	AKT1 KRAS
9	liver development	GO:0001889	9.33	KRAS PIK3CA RB1CC1
10	negative regulation of macroautophagy	GO:0016242	9.32	AKT1 PIK3CA
11	anoikis	GO:0043276	9.26	AKT1 PIK3CA
12	cytokine-mediated signaling pathway	GO:0019221	9.26	AKT1 KRAS PIK3CA TP53
13	epidermal growth factor receptor signaling pathway	GO:0007173	8.8	AKT1 KRAS PIK3CA

Molecular functions related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein phosphatase 2A binding	GO:0051721	8.62	AKT1 TP53

Sources

Sources for Rare Adenocarcinoma of the Breast

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia