MCID: RRD004
MIFTS: 27

Rare Adenocarcinoma of the Breast

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Rare Adenocarcinoma of the Breast

Summaries for Rare Adenocarcinoma of the Breast

MalaCards based summary : Rare Adenocarcinoma of the Breast is related to ovarian clear cell adenofibroma and hyperplastic polyposis syndrome. An important gene associated with Rare Adenocarcinoma of the Breast is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Parkinson disease and Endometrial cancer. Affiliated tissues include breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Rare Adenocarcinoma of the Breast

Diseases in the Breast Adenocarcinoma family:

Rare Adenocarcinoma of the Breast

Diseases related to Rare Adenocarcinoma of the Breast via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 ovarian clear cell adenofibroma 10.1 PIK3CA KRAS
2 hyperplastic polyposis syndrome 10.1 TP53 KRAS
3 adenosquamous lung carcinoma 10.1 PIK3CA KRAS
4 gallbladder benign neoplasm 10.1 TP53 KRAS
5 wolffian duct adenocarcinoma 10.1 TP53 KRAS
6 liver angiosarcoma 10.1 TP53 KRAS
7 angiosarcoma 10.1 TP53 KRAS
8 biliary tract benign neoplasm 10.1 TP53 KRAS
9 tumor of exocrine pancreas 10.1 TP53 KRAS
10 endosalpingiosis 10.1 TP53 KRAS
11 embryonal rhabdomyosarcoma 10.1 TP53 KRAS
12 appendix disease 10.1 TP53 KRAS
13 papillary adenoma 10.1 TP53 KRAS
14 appendix cancer 10.1 TP53 KRAS
15 oculoectodermal syndrome 10.1 PIK3CA KRAS
16 rare carcinoma of pancreas 10.1 TP53 KRAS
17 nasal cavity cancer 10.1 TP53 KRAS
18 skin papilloma 10.1 TP53 KRAS
19 duodenum cancer 10.1 TP53 KRAS
20 cystadenocarcinoma 10.1 TP53 PIK3CA
21 mature teratoma 10.1 TP53 KRAS
22 papillary serous adenocarcinoma 10.1 TP53 KRAS
23 rare head and neck tumor 10.1 TP53 PIK3CA
24 villous adenoma 10.1 TP53 KRAS
25 respiratory system benign neoplasm 10.1 TP53 KRAS
26 pseudomyxoma peritonei 10.1 TP53 KRAS
27 signet ring cell adenocarcinoma 10.1 TP53 KRAS
28 parameningeal embryonal rhabdomyosarcoma 10.1 TP53 PIK3CA
29 cystic teratoma 10.1 TP53 KRAS
30 pulmonary blastoma 10.1 TP53 KRAS
31 ovarian carcinosarcoma 10.1 TP53 PIK3CA
32 lipomatosis 10.1 PIK3CA KRAS
33 breast sarcoma 10.1 TP53 PIK3CA
34 vulva squamous cell carcinoma 10.1 TP53 PIK3CA
35 barrett's adenocarcinoma 10.1 TP53 KRAS
36 malignant spiradenoma 10.1 TP53 PIK3CA
37 uterine adnexa cancer 10.1 TP53 PIK3CA
38 lung adenoma 10.1 TP53 KRAS
39 acanthoma 10.1 TP53 PIK3CA
40 schimmelpenning-feuerstein-mims syndrome 10.1 PIK3CA KRAS
41 anal squamous cell carcinoma 10.1 TP53 PIK3CA
42 vulvar disease 10.1 TP53 PIK3CA
43 hypertrophy of breast 10.1 TP53 PIK3CA
44 cervical adenocarcinoma 10.1 TP53 KRAS
45 epithelial-myoepithelial carcinoma 10.0 TP53 PIK3CA
46 uterine benign neoplasm 10.0 TP53 KRAS
47 myoepithelial carcinoma 10.0 TP53 PIK3CA
48 reproductive organ benign neoplasm 10.0 TP53 KRAS
49 colonic benign neoplasm 10.0 TP53 KRAS
50 endocervical carcinoma 10.0 TP53 PIK3CA

Graphical network of the top 20 diseases related to Rare Adenocarcinoma of the Breast:



Diseases related to Rare Adenocarcinoma of the Breast

Symptoms & Phenotypes for Rare Adenocarcinoma of the Breast

GenomeRNAi Phenotypes related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-10 9.8 RB1CC1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.8 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.8 KRAS RB1CC1 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.8 TP53
5 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.8 TP53
6 Increased shRNA abundance (Z-score > 2) GR00366-A-171 9.8 RB1CC1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-179 9.8 RB1CC1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-184 9.8 TP53
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.8 TP53
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.8 TP53
11 Increased shRNA abundance (Z-score > 2) GR00366-A-20 9.8 TP53
12 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.8 KRAS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.8 TP53
14 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.8 RB1CC1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.8 TP53
16 Increased shRNA abundance (Z-score > 2) GR00366-A-59 9.8 RB1CC1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.8 PIK3CA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-62 9.8 TP53
19 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.8 KRAS

MGI Mouse Phenotypes related to Rare Adenocarcinoma of the Breast:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.46 KRAS PIK3CA RB1CC1 TP53
2 no phenotypic analysis MP:0003012 9.26 KRAS PIK3CA RB1CC1 TP53
3 pigmentation MP:0001186 8.8 KRAS RB1CC1 TP53

Drugs & Therapeutics for Rare Adenocarcinoma of the Breast

Search Clinical Trials , NIH Clinical Center for Rare Adenocarcinoma of the Breast

Genetic Tests for Rare Adenocarcinoma of the Breast

Anatomical Context for Rare Adenocarcinoma of the Breast

MalaCards organs/tissues related to Rare Adenocarcinoma of the Breast:

40
Breast

Publications for Rare Adenocarcinoma of the Breast

Variations for Rare Adenocarcinoma of the Breast

ClinVar genetic disease variations for Rare Adenocarcinoma of the Breast:

6 (show all 11) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 RB1CC1 nsv1067860deletion Pathogenic 3976 8:53536328-53598019 8:52623768-52685459
2 RB1CC1 nsv1067861deletion Pathogenic 3977 8:53537321-53574220 8:52624761-52661660
3 SLC22A18 NM_002555.5(SLC22A18):c.864_865insNC_000011.10:g.2919738_2919848insertion Pathogenic 6976
4 KRAS NM_033360.4(KRAS):c.38G>A (p.Gly13Asp)SNV Pathogenic 12580 rs112445441 12:25398281-25398281 12:25245347-25245347
5 PIK3CA NM_006218.4(PIK3CA):c.3140A>G (p.His1047Arg)SNV Pathogenic 13652 rs121913279 3:178952085-178952085 3:179234297-179234297
6 PIK3CA NM_006218.4(PIK3CA):c.3140A>T (p.His1047Leu)SNV Pathogenic 13653 rs121913279 3:178952085-178952085 3:179234297-179234297
7 PIK3CA NM_006218.4(PIK3CA):c.1633G>A (p.Glu545Lys)SNV Pathogenic 13655 rs104886003 3:178936091-178936091 3:179218303-179218303
8 TP53 NM_000546.6(TP53):c.451C>T (p.Pro151Ser)SNV Pathogenic/Likely pathogenic 12370 rs28934874 17:7578479-7578479 17:7675161-7675161
9 PIK3CA NM_006218.4(PIK3CA):c.1636C>G (p.Gln546Glu)SNV Pathogenic/Likely pathogenic 13654 rs121913286 3:178936094-178936094 3:179218306-179218306
10 TP53 NM_001126112.2(TP53):c.451C>A (p.Pro151Thr)SNV Likely pathogenic 12369 rs28934874 17:7578479-7578479 17:7675161-7675161
11 AKT1 NM_005163.2(AKT1):c.49G>A (p.Glu17Lys)SNV Uncertain significance 13983 rs121434592 14:105246551-105246551 14:104780214-104780214

Expression for Rare Adenocarcinoma of the Breast

Search GEO for disease gene expression data for Rare Adenocarcinoma of the Breast.

Pathways for Rare Adenocarcinoma of the Breast

Pathways related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.79 TP53 RB1CC1 PIK3CA KRAS
2
Show member pathways
12.6 TP53 PIK3CA KRAS
3 12.57 TP53 PIK3CA KRAS
4
Show member pathways
12.48 TP53 PIK3CA KRAS
5
Show member pathways
12.45 TP53 PIK3CA KRAS
6
Show member pathways
12.43 TP53 PIK3CA KRAS
7
Show member pathways
12.42 TP53 PIK3CA KRAS
8
Show member pathways
12.38 TP53 PIK3CA KRAS
9
Show member pathways
12.34 TP53 PIK3CA KRAS
10
Show member pathways
12.31 TP53 PIK3CA KRAS
11 12.24 TP53 PIK3CA KRAS
12
Show member pathways
12.21 TP53 PIK3CA KRAS
13
Show member pathways
12.2 TP53 PIK3CA KRAS
14
Show member pathways
12.13 TP53 PIK3CA KRAS
15 12.03 TP53 PIK3CA KRAS
16 11.98 TP53 PIK3CA KRAS
17 11.96 TP53 PIK3CA KRAS
18
Show member pathways
11.94 TP53 PIK3CA KRAS
19
Show member pathways
11.89 PIK3CA KRAS
20
Show member pathways
11.84 TP53 PIK3CA KRAS
21 11.8 TP53 PIK3CA KRAS
22 11.72 RB1CC1 PIK3CA KRAS
23
Show member pathways
11.64 PIK3CA KRAS
24 11.63 TP53 PIK3CA KRAS
25
Show member pathways
11.6 PIK3CA KRAS
26 11.57 TP53 KRAS
27 11.57 TP53 PIK3CA KRAS
28 11.53 TP53 PIK3CA
29 11.53 TP53 KRAS
30 11.49 TP53 KRAS
31 11.49 TP53 PIK3CA KRAS
32 11.47 TP53 PIK3CA
33
Show member pathways
11.47 TP53 PIK3CA
34 11.45 PIK3CA KRAS
35 11.36 TP53 PIK3CA
36 11.18 TP53 PIK3CA KRAS
37 11.16 PIK3CA KRAS
38
Show member pathways
11.1 TP53 RB1CC1 PIK3CA KRAS
39 10.98 PIK3CA KRAS
40 10.61 RB1CC1 PIK3CA KRAS

GO Terms for Rare Adenocarcinoma of the Breast

Biological processes related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.16 TP53 KRAS
2 cytokine-mediated signaling pathway GO:0019221 9.13 TP53 PIK3CA KRAS
3 liver development GO:0001889 8.8 RB1CC1 PIK3CA KRAS

Sources for Rare Adenocarcinoma of the Breast

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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