MCID: RRD004
MIFTS: 34

Rare Adenocarcinoma of the Breast

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Rare Adenocarcinoma of the Breast

Summaries for Rare Adenocarcinoma of the Breast

MalaCards based summary : Rare Adenocarcinoma of the Breast is related to hidradenoma and proteus syndrome. An important gene associated with Rare Adenocarcinoma of the Breast is AKT1 (AKT Serine/Threonine Kinase 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Response to elevated platelet cytosolic Ca2+. Affiliated tissues include lung, brain and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Rare Adenocarcinoma of the Breast

Diseases in the Breast Adenocarcinoma family:

Rare Adenocarcinoma of the Breast

Diseases related to Rare Adenocarcinoma of the Breast via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 hidradenoma 10.1 AKT1 PIK3CA
2 proteus syndrome 10.1 AKT1 PIK3CA
3 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.1 AKT1 PIK3CA
4 apocrine adenoma 10.1 KRAS PIK3CA
5 aggressive digital papillary adenocarcinoma 10.1 KRAS PIK3CA
6 lung adenoid cystic carcinoma 10.1 KRAS PIK3CA
7 acneiform dermatitis 10.1 KRAS PIK3CA
8 undifferentiated pleomorphic sarcoma 10.1 KRAS PIK3CA
9 adenosquamous lung carcinoma 10.1 KRAS PIK3CA
10 adult hepatocellular carcinoma 10.1 PIK3CA TP53
11 malignant spiradenoma 10.1 PIK3CA TP53
12 uterine corpus serous adenocarcinoma 10.1 PIK3CA TP53
13 breast squamous cell carcinoma 10.1 PIK3CA TP53
14 uterine body mixed cancer 10.1 PIK3CA TP53
15 uterine corpus cancer 10.1 PIK3CA TP53
16 nevus, epidermal 10.1 KRAS PIK3CA
17 nasopharyngeal disease 10.0 AKT1 TP53
18 hyperplastic polyposis syndrome 10.0 KRAS TP53
19 mutyh-associated polyposis 10.0 KRAS TP53
20 pharynx cancer 10.0 AKT1 TP53
21 nasal cavity adenocarcinoma 10.0 KRAS TP53
22 connective tissue cancer 10.0 AKT1 TP53
23 mature teratoma 10.0 KRAS TP53
24 skin squamous cell carcinoma 10.0 PIK3CA TP53
25 pulmonary blastoma 10.0 KRAS TP53
26 biliary papillomatosis 10.0 KRAS TP53
27 penile cancer 10.0 PIK3CA TP53
28 cervix disease 10.0 AKT1 TP53
29 supratentorial cancer 10.0 AKT1 TP53
30 biliary tract neoplasm 10.0 KRAS TP53
31 liver angiosarcoma 10.0 KRAS TP53
32 cerebrum cancer 10.0 AKT1 TP53
33 brain stem glioma 10.0 PIK3CA TP53
34 pseudomyxoma peritonei 10.0 KRAS TP53
35 autonomic nervous system neoplasm 10.0 AKT1 TP53
36 ampulla of vater cancer 10.0 KRAS TP53
37 peripheral nervous system neoplasm 10.0 AKT1 TP53
38 gastrointestinal system benign neoplasm 10.0 KRAS TP53
39 barrett's adenocarcinoma 10.0 KRAS TP53
40 intestinal benign neoplasm 10.0 KRAS TP53
41 lung benign neoplasm 10.0 KRAS TP53
42 bladder disease 10.0 AKT1 TP53
43 ductal carcinoma in situ 10.0 AKT1 TP53
44 central nervous system cancer 10.0 AKT1 TP53
45 colorectal adenoma 10.0 KRAS TP53
46 cell type benign neoplasm 10.0 KRAS TP53
47 leukocyte disease 9.9 AKT1 TP53
48 anaplastic thyroid cancer 9.9 PIK3CA TP53
49 anal squamous cell carcinoma 9.9 AKT1 PIK3CA TP53
50 squamous cell carcinoma 9.9 AKT1 PIK3CA TP53

Graphical network of the top 20 diseases related to Rare Adenocarcinoma of the Breast:



Diseases related to Rare Adenocarcinoma of the Breast

Symptoms & Phenotypes for Rare Adenocarcinoma of the Breast

GenomeRNAi Phenotypes related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

26 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.96 KRAS
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.96 TP53
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.96 KRAS RB1CC1 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.96 TP53
5 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.96 PIK3CA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.96 PIK3CA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.96 PIK3CA
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.96 KRAS
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.96 TP53
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.96 KRAS PIK3CA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.96 TP53
12 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.96 PIK3CA TP53
13 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.96 KRAS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.96 RB1CC1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.96 KRAS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.96 TP53
17 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.96 RB1CC1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.96 TP53
19 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.96 PIK3CA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.96 KRAS PIK3CA RB1CC1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.96 KRAS
22 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.96 KRAS
23 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.96 KRAS

MGI Mouse Phenotypes related to Rare Adenocarcinoma of the Breast:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.77 AKT1 KRAS PIK3CA RB1CC1 TP53
2 integument MP:0010771 9.72 AKT1 KRAS PIK3CA RB1CC1 TP53
3 liver/biliary system MP:0005370 9.56 AKT1 KRAS RB1CC1 TP53
4 muscle MP:0005369 9.55 AKT1 KRAS PIK3CA RB1CC1 TP53
5 neoplasm MP:0002006 9.26 AKT1 KRAS PIK3CA TP53
6 no phenotypic analysis MP:0003012 8.92 KRAS PIK3CA RB1CC1 TP53

Drugs & Therapeutics for Rare Adenocarcinoma of the Breast

Search Clinical Trials , NIH Clinical Center for Rare Adenocarcinoma of the Breast

Genetic Tests for Rare Adenocarcinoma of the Breast

Anatomical Context for Rare Adenocarcinoma of the Breast

MalaCards organs/tissues related to Rare Adenocarcinoma of the Breast:

41
Lung, Brain, Bone, Colon, Ovary, Pancreas, Thyroid

Publications for Rare Adenocarcinoma of the Breast

Variations for Rare Adenocarcinoma of the Breast

ClinVar genetic disease variations for Rare Adenocarcinoma of the Breast:

6 (show all 22)
# Gene Variation Type Significance SNP ID Assembly Location
1 RB1CC1 NG_015833.1: g.34008_95699del61692 deletion Pathogenic GRCh38 Chromosome 8, 52623768: 52685459
2 RB1CC1 NG_015833.1: g.34008_95699del61692 deletion Pathogenic GRCh37 Chromosome 8, 53536328: 53598019
3 RB1CC1 NG_015833.1: g.57807_94706del36900 deletion Pathogenic GRCh38 Chromosome 8, 52624761: 52661660
4 RB1CC1 NG_015833.1: g.57807_94706del36900 deletion Pathogenic GRCh37 Chromosome 8, 53537321: 53574220
5 SLC22A18 NM_002555.5(SLC22A18): c.864_865insNC_000011.10: g.2919738_2919848 insertion Pathogenic
6 TP53 NM_000546.5(TP53): c.451C> A (p.Pro151Thr) single nucleotide variant Likely pathogenic rs28934874 GRCh37 Chromosome 17, 7578479: 7578479
7 TP53 NM_000546.5(TP53): c.451C> A (p.Pro151Thr) single nucleotide variant Likely pathogenic rs28934874 GRCh38 Chromosome 17, 7675161: 7675161
8 TP53 NM_000546.5(TP53): c.451C> T (p.Pro151Ser) single nucleotide variant Pathogenic/Likely pathogenic rs28934874 GRCh37 Chromosome 17, 7578479: 7578479
9 TP53 NM_000546.5(TP53): c.451C> T (p.Pro151Ser) single nucleotide variant Pathogenic/Likely pathogenic rs28934874 GRCh38 Chromosome 17, 7675161: 7675161
10 KRAS NM_033360.3(KRAS): c.38G> A (p.Gly13Asp) single nucleotide variant Pathogenic rs112445441 GRCh37 Chromosome 12, 25398281: 25398281
11 KRAS NM_033360.3(KRAS): c.38G> A (p.Gly13Asp) single nucleotide variant Pathogenic rs112445441 GRCh38 Chromosome 12, 25245347: 25245347
12 PIK3CA NM_006218.3(PIK3CA): c.3140A> G (p.His1047Arg) single nucleotide variant Pathogenic rs121913279 GRCh37 Chromosome 3, 178952085: 178952085
13 PIK3CA NM_006218.3(PIK3CA): c.3140A> G (p.His1047Arg) single nucleotide variant Pathogenic rs121913279 GRCh38 Chromosome 3, 179234297: 179234297
14 PIK3CA NM_006218.3(PIK3CA): c.3140A> T (p.His1047Leu) single nucleotide variant Pathogenic rs121913279 GRCh37 Chromosome 3, 178952085: 178952085
15 PIK3CA NM_006218.3(PIK3CA): c.3140A> T (p.His1047Leu) single nucleotide variant Pathogenic rs121913279 GRCh38 Chromosome 3, 179234297: 179234297
16 PIK3CA NM_006218.3(PIK3CA): c.1636C> G (p.Gln546Glu) single nucleotide variant Pathogenic/Likely pathogenic rs121913286 GRCh37 Chromosome 3, 178936094: 178936094
17 PIK3CA NM_006218.3(PIK3CA): c.1636C> G (p.Gln546Glu) single nucleotide variant Pathogenic/Likely pathogenic rs121913286 GRCh38 Chromosome 3, 179218306: 179218306
18 PIK3CA NM_006218.3(PIK3CA): c.1633G> A (p.Glu545Lys) single nucleotide variant Pathogenic/Likely pathogenic rs104886003 GRCh37 Chromosome 3, 178936091: 178936091
19 PIK3CA NM_006218.3(PIK3CA): c.1633G> A (p.Glu545Lys) single nucleotide variant Pathogenic/Likely pathogenic rs104886003 GRCh38 Chromosome 3, 179218303: 179218303
20 PIK3CA NM_006218.3(PIK3CA): c.1633G> A (p.Glu545Lys) single nucleotide variant Pathogenic/Likely pathogenic rs104886003 NCBI36 Chromosome 3, 180418785: 180418785
21 AKT1 NM_005163.2(AKT1): c.49G> A (p.Glu17Lys) single nucleotide variant Pathogenic/Likely pathogenic rs121434592 GRCh37 Chromosome 14, 105246551: 105246551
22 AKT1 NM_005163.2(AKT1): c.49G> A (p.Glu17Lys) single nucleotide variant Pathogenic/Likely pathogenic rs121434592 GRCh38 Chromosome 14, 104780214: 104780214

Expression for Rare Adenocarcinoma of the Breast

Search GEO for disease gene expression data for Rare Adenocarcinoma of the Breast.

Pathways for Rare Adenocarcinoma of the Breast

Pathways related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.2 AKT1 KRAS PIK3CA TP53
2
Show member pathways
13.16 AKT1 KRAS PIK3CA TP53
3
Show member pathways
12.91 AKT1 KRAS PIK3CA TP53
4
Show member pathways
12.85 AKT1 KRAS PIK3CA TP53
5
Show member pathways
12.81 AKT1 KRAS PIK3CA TP53
6
Show member pathways
12.78 AKT1 KRAS PIK3CA TP53
7
Show member pathways
12.73 AKT1 KRAS PIK3CA TP53
8 12.69 AKT1 KRAS PIK3CA TP53
9
Show member pathways
12.66 AKT1 KRAS PIK3CA TP53
10
Show member pathways
12.62 AKT1 KRAS PIK3CA TP53
11
Show member pathways
12.61 AKT1 KRAS PIK3CA
12
Show member pathways
12.61 AKT1 KRAS PIK3CA TP53
13
Show member pathways
12.58 AKT1 KRAS PIK3CA TP53
14
Show member pathways
12.56 AKT1 KRAS TP53
15
Show member pathways
12.56 AKT1 KRAS PIK3CA TP53
16
Show member pathways
12.55 AKT1 KRAS PIK3CA
17
Show member pathways
12.48 AKT1 KRAS PIK3CA
18
Show member pathways
12.44 AKT1 KRAS PIK3CA TP53
19 12.42 KRAS PIK3CA TP53
20
Show member pathways
12.39 AKT1 KRAS PIK3CA
21
Show member pathways
12.39 AKT1 KRAS PIK3CA TP53
22
Show member pathways
12.35 AKT1 KRAS PIK3CA
23
Show member pathways
12.34 AKT1 PIK3CA TP53
24
Show member pathways
12.34 AKT1 KRAS PIK3CA TP53
25
Show member pathways
12.33 AKT1 KRAS PIK3CA
26
Show member pathways
12.32 AKT1 KRAS PIK3CA
27
Show member pathways
12.32 AKT1 KRAS PIK3CA TP53
28
Show member pathways
12.31 AKT1 KRAS PIK3CA
29
Show member pathways
12.31 AKT1 KRAS PIK3CA
30
Show member pathways
12.31 AKT1 KRAS PIK3CA
31
Show member pathways
12.3 AKT1 PIK3CA TP53
32
Show member pathways
12.28 AKT1 KRAS PIK3CA
33
Show member pathways
12.26 AKT1 KRAS PIK3CA
34
Show member pathways
12.26 AKT1 KRAS PIK3CA TP53
35
Show member pathways
12.25 AKT1 KRAS PIK3CA
36 12.23 AKT1 KRAS PIK3CA TP53
37
Show member pathways
12.22 AKT1 PIK3CA TP53
38
Show member pathways
12.22 AKT1 KRAS PIK3CA
39
Show member pathways
12.22 AKT1 KRAS PIK3CA
40 12.19 AKT1 PIK3CA TP53
41 12.19 KRAS PIK3CA TP53
42
Show member pathways
12.16 AKT1 KRAS TP53
43
Show member pathways
12.16 AKT1 KRAS TP53
44
Show member pathways
12.11 AKT1 KRAS PIK3CA
45 12.11 AKT1 KRAS PIK3CA TP53
46
Show member pathways
12.1 AKT1 KRAS PIK3CA
47 12.09 AKT1 KRAS TP53
48 12.06 AKT1 KRAS TP53
49
Show member pathways
12.05 AKT1 KRAS TP53
50
Show member pathways
12.04 AKT1 KRAS PIK3CA

GO Terms for Rare Adenocarcinoma of the Breast

Biological processes related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.69 AKT1 KRAS TP53
2 positive regulation of protein phosphorylation GO:0001934 9.54 AKT1 KRAS RB1CC1
3 glucose metabolic process GO:0006006 9.52 AKT1 PIK3CA
4 T cell costimulation GO:0031295 9.49 AKT1 PIK3CA
5 epidermal growth factor receptor signaling pathway GO:0007173 9.48 AKT1 PIK3CA
6 protein kinase B signaling GO:0043491 9.46 AKT1 PIK3CA
7 phosphatidylinositol 3-kinase signaling GO:0014065 9.43 AKT1 PIK3CA
8 positive regulation of nitric-oxide synthase activity GO:0051000 9.4 AKT1 KRAS
9 striated muscle cell differentiation GO:0051146 9.32 AKT1 KRAS
10 negative regulation of macroautophagy GO:0016242 9.26 AKT1 PIK3CA
11 anoikis GO:0043276 9.16 AKT1 PIK3CA
12 liver development GO:0001889 9.13 KRAS PIK3CA RB1CC1
13 cytokine-mediated signaling pathway GO:0019221 8.92 AKT1 KRAS PIK3CA TP53

Molecular functions related to Rare Adenocarcinoma of the Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase 2A binding GO:0051721 8.62 AKT1 TP53

Sources for Rare Adenocarcinoma of the Breast

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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