MCID: RRC011
MIFTS: 39

Rare Cancer of Corpus Uteri

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Rare Cancer of Corpus Uteri

MalaCards integrated aliases for Rare Cancer of Corpus Uteri:

Name: Rare Cancer of Corpus Uteri 58
Rare Malignant Tumor of Corpus Uteri 58

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

UMLS via Orphanet 72 C0153574
Orphanet 58 ORPHA213569

Summaries for Rare Cancer of Corpus Uteri

MalaCards based summary : Rare Cancer of Corpus Uteri, also known as rare malignant tumor of corpus uteri, is related to vulvar intraepithelial neoplasia and nevus of ota. An important gene associated with Rare Cancer of Corpus Uteri is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are RET signaling and Signaling by GPCR. Affiliated tissues include breast, thyroid and lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Rare Cancer of Corpus Uteri

Diseases related to Rare Cancer of Corpus Uteri via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 309)
# Related Disease Score Top Affiliating Genes
1 vulvar intraepithelial neoplasia 10.5 TP53 CTNNB1
2 nevus of ota 10.5 TP53 BRAF
3 gastric papillary adenocarcinoma 10.4 TP53 ERBB2
4 nonseminomatous germ cell tumor 10.4 ERBB2 BRAF
5 spitzoid melanoma 10.4 HRAS BRAF
6 parotid gland cancer 10.4 TP53 ERBB2
7 comedo carcinoma 10.4 TP53 ERBB2
8 struma ovarii 10.4 KRAS BRAF
9 pleomorphic adenoma carcinoma 10.4 TP53 ERBB2
10 embryonal sarcoma 10.3 TP53 CTNNB1
11 bent bone dysplasia syndrome 10.3 FGFR2 ERBB2
12 breast malignant phyllodes tumor 10.3 TP53 ERBB2
13 squamous cell papilloma 10.3 TP53 HRAS
14 urachal adenocarcinoma 10.3 KRAS BRAF
15 large intestine adenocarcinoma 10.3 TP53 ERBB2
16 apocrine adenoma 10.3 KRAS BRAF
17 splenic diffuse red pulp small b-cell lymphoma 10.3 TP53 MAP2K1
18 signet ring basal cell carcinoma 10.3 KRAS HRAS
19 thyroid hurthle cell adenoma 10.3 PTEN PIK3CA
20 trachea carcinoma in situ 10.3 KRAS HRAS
21 syringocystadenoma papilliferum 10.3 KRAS BRAF
22 adenosquamous lung carcinoma 10.3 PIK3CA KRAS
23 nasal cavity adenocarcinoma 10.3 KRAS HRAS
24 testicular spermatocytic seminoma 10.3 HRAS FGFR2
25 liver angiosarcoma 10.3 TP53 KRAS
26 ampulla of vater neoplasm 10.3 KRAS HRAS
27 periampullary adenoma 10.3 KRAS HRAS
28 breast sarcoma 10.3 TP53 PIK3CA ERBB2
29 rare head and neck tumor 10.3 TP53 PIK3CA FGFR2
30 lobular neoplasia 10.3 TP53 ERBB2 CTNNB1
31 myh-associated polyposis 10.2 KRAS HRAS
32 appendix adenocarcinoma 10.2 KRAS HRAS
33 endosalpingiosis 10.2 TP53 KRAS
34 gallbladder adenocarcinoma 10.2 TP53 PIK3CA ERBB2
35 mucinous lung adenocarcinoma 10.2 KRAS HRAS
36 childhood medulloblastoma 10.2 TP53 ERBB2 CTNNB1
37 dermatosis papulosa nigra 10.2 PIK3CA MTOR
38 adult malignant schwannoma 10.2 TP53 HRAS
39 primary peritoneal carcinoma 10.2 TP53 ERBB2
40 papillary craniopharyngioma 10.2 CTNNB1 BRAF
41 undifferentiated pleomorphic sarcoma 10.2 PIK3CA KRAS
42 liver benign neoplasm 10.2 TP53 HRAS CTNNB1
43 granulosa cell tumor of the ovary 10.2 TP53 ERBB2
44 pancreatic intraductal papillary-mucinous neoplasm 10.2 KRAS HRAS
45 apocrine adenosis of breast 10.2 TP53 FGFR2 ERBB2
46 spitz nevus 10.2 TP53 HRAS BRAF
47 gastric diffuse adenocarcinoma 10.2 TP53 ERBB2
48 rare adenocarcinoma of the breast 10.2 TP53 PIK3CA KRAS
49 ascending colon cancer 10.2 KRAS HRAS
50 keratosis 10.2 TP53 PIK3CA HRAS

Graphical network of the top 20 diseases related to Rare Cancer of Corpus Uteri:



Diseases related to Rare Cancer of Corpus Uteri

Symptoms & Phenotypes for Rare Cancer of Corpus Uteri

GenomeRNAi Phenotypes related to Rare Cancer of Corpus Uteri according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.97 MTOR HRAS KRAS PIK3CA BRAF
2 Decreased viability GR00106-A-0 10.97 KRAS
3 Decreased viability GR00107-A-1 10.97 MAP2K1
4 Decreased viability GR00221-A-1 10.97 MTOR HRAS NRAS KRAS PIK3CA
5 Decreased viability GR00221-A-2 10.97 HRAS KRAS PIK3CA
6 Decreased viability GR00221-A-3 10.97 MAP2K1 ERBB2 HRAS NRAS
7 Decreased viability GR00221-A-4 10.97 MTOR ERBB2 PIK3CA BRAF
8 Decreased viability GR00301-A 10.97 FGFR2 KRAS BRAF
9 Decreased viability GR00342-S-1 10.97 FGFR2 MAP2K1 MTOR
10 Decreased viability GR00342-S-2 10.97 FGFR2 MAP2K1 MTOR
11 Decreased viability GR00342-S-3 10.97 FGFR2 MAP2K1
12 Decreased viability GR00381-A-1 10.97 KRAS BRAF
13 Decreased viability GR00402-S-2 10.97 FGFR2 MAP2K1 MTOR ERBB2 HRAS NRAS
14 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.97 CTNNB1 ERBB2 FGFR2 HRAS MTOR NRAS
15 Decreased cell migration GR00055-A-1 9.88 BRAF CTNNB1 HRAS KRAS MTOR PIK3CA
16 Decreased viability in esophageal squamous lineage GR00235-A 9.86 BRAF CTNNB1 ERBB2 HRAS KRAS PIK3CA
17 Increased cell death HMECs cells GR00103-A-0 9.55 CTNNB1 PIK3CA PPP2R1A PTEN TP53
18 Increased cell migration GR00055-A-3 9.43 BRAF CTNNB1 HRAS KRAS MTOR PIK3CA
19 Reduced mammosphere formation GR00396-S 9.17 BRAF HRAS KRAS MTOR NRAS PPP2R1A

MGI Mouse Phenotypes related to Rare Cancer of Corpus Uteri:

45 (show all 27)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.41 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
2 cardiovascular system MP:0005385 10.4 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
3 growth/size/body region MP:0005378 10.4 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
4 homeostasis/metabolism MP:0005376 10.38 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
5 endocrine/exocrine gland MP:0005379 10.37 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
6 cellular MP:0005384 10.36 BRAF CTNNB1 ERBB2 FGFR2 KRAS MAP2K1
7 embryo MP:0005380 10.34 BRAF CTNNB1 ERBB2 FGFR2 KRAS MAP2K1
8 mortality/aging MP:0010768 10.32 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
9 digestive/alimentary MP:0005381 10.3 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
10 integument MP:0010771 10.29 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
11 craniofacial MP:0005382 10.26 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
12 neoplasm MP:0002006 10.26 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
13 immune system MP:0005387 10.21 BRAF CTNNB1 FGFR2 KRAS MTOR NRAS
14 nervous system MP:0003631 10.2 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
15 normal MP:0002873 10.18 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
16 muscle MP:0005369 10.15 BRAF CTNNB1 ERBB2 FGFR2 KRAS MTOR
17 limbs/digits/tail MP:0005371 10.14 BRAF CTNNB1 ERBB2 FGFR2 KRAS NRAS
18 adipose tissue MP:0005375 10.11 BRAF FGFR2 MTOR PIK3CA PTEN TP53
19 liver/biliary system MP:0005370 10.07 BRAF CTNNB1 FGFR2 KRAS NRAS PTEN
20 hearing/vestibular/ear MP:0005377 10.05 BRAF CTNNB1 FGFR2 KRAS MAP2K1 TP53
21 no phenotypic analysis MP:0003012 10.03 CTNNB1 FGFR2 HRAS KRAS MTOR NRAS
22 renal/urinary system MP:0005367 9.92 BRAF CTNNB1 FGFR2 HRAS KRAS MTOR
23 pigmentation MP:0001186 9.91 BRAF CTNNB1 FGFR2 KRAS NRAS PTEN
24 reproductive system MP:0005389 9.91 BRAF CTNNB1 ERBB2 FGFR2 KRAS MAP2K1
25 respiratory system MP:0005388 9.81 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
26 skeleton MP:0005390 9.73 BRAF CTNNB1 ERBB2 FGFR2 HRAS KRAS
27 vision/eye MP:0005391 9.28 BRAF CTNNB1 FGFR2 KRAS MAP2K1 NRAS

Drugs & Therapeutics for Rare Cancer of Corpus Uteri

Search Clinical Trials , NIH Clinical Center for Rare Cancer of Corpus Uteri

Genetic Tests for Rare Cancer of Corpus Uteri

Anatomical Context for Rare Cancer of Corpus Uteri

MalaCards organs/tissues related to Rare Cancer of Corpus Uteri:

40
Breast, Thyroid, Lung, Skin, Ovary, Myeloid, Colon

Publications for Rare Cancer of Corpus Uteri

Variations for Rare Cancer of Corpus Uteri

ClinVar genetic disease variations for Rare Cancer of Corpus Uteri:

6 (show top 50) (show all 287) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TP53 NM_000546.5(TP53):c.832C>A (p.Pro278Thr)SNV Likely pathogenic,drug response 376643 rs17849781 17:7577106-7577106 17:7673788-7673788
2 TP53 NM_000546.5(TP53):c.517G>T (p.Val173Leu)SNV Pathogenic 376668 rs876660754 17:7578413-7578413 17:7675095-7675095
3 TP53 NM_000546.5(TP53):c.537T>G (p.His179Gln)SNV Pathogenic 376607 rs876660821 17:7578393-7578393 17:7675075-7675075
4 TP53 NM_000546.5(TP53):c.578A>C (p.His193Pro)SNV Pathogenic 376612 rs786201838 17:7578271-7578271 17:7674953-7674953
5 TP53 NM_000546.5(TP53):c.818G>T (p.Arg273Leu)SNV Pathogenic 376655 rs28934576 17:7577120-7577120 17:7673802-7673802
6 PIK3CA NM_006218.4(PIK3CA):c.1357G>A (p.Glu453Lys)SNV Pathogenic 376470 rs1057519925 3:178928079-178928079 3:179210291-179210291
7 TP53 NM_000546.5(TP53):c.713G>T (p.Cys238Phe)SNV Pathogenic 376574 rs730882005 17:7577568-7577568 17:7674250-7674250
8 TP53 NM_000546.5(TP53):c.712T>C (p.Cys238Arg)SNV Pathogenic 376576 rs1057519981 17:7577569-7577569 17:7674251-7674251
9 TP53 NM_000546.5(TP53):c.841G>T (p.Asp281Tyr)SNV Pathogenic 376585 rs764146326 17:7577097-7577097 17:7673779-7673779
10 TP53 NM_000546.5(TP53):c.841G>A (p.Asp281Asn)SNV Pathogenic 376586 rs764146326 17:7577097-7577097 17:7673779-7673779
11 NRAS NM_002524.5(NRAS):c.34G>A (p.Gly12Ser)SNV Pathogenic 177778 rs121913250 1:115258748-115258748 1:114716127-114716127
12 PPP2R1A NM_014225.6(PPP2R1A):c.536C>T (p.Pro179Leu)SNV Pathogenic 190313 rs786205228 19:52715971-52715971 19:52212718-52212718
13 NRAS NM_002524.5(NRAS):c.35G>C (p.Gly12Ala)SNV Pathogenic 219097 rs121913237 1:115258747-115258747 1:114716126-114716126
14 TP53 NM_000546.5(TP53):c.517G>A (p.Val173Met)SNV Pathogenic 233951 rs876660754 17:7578413-7578413 17:7675095-7675095
15 PTEN NM_000314.7(PTEN):c.389G>A (p.Arg130Gln)SNV Pathogenic 7829 rs121909229 10:89692905-89692905 10:87933148-87933148
16 TP53 NM_000546.5(TP53):c.742C>T (p.Arg248Trp)SNV Pathogenic 12347 rs121912651 17:7577539-7577539 17:7674221-7674221
17 TP53 NM_000546.5(TP53):c.743G>A (p.Arg248Gln)SNV Pathogenic 12356 rs11540652 17:7577538-7577538 17:7674220-7674220
18 TP53 NM_000546.5(TP53):c.659A>C (p.Tyr220Ser)SNV Pathogenic 12383 rs121912666 17:7578190-7578190 17:7674872-7674872
19 HRAS NM_005343.4(HRAS):c.34G>A (p.Gly12Ser)SNV Pathogenic 12602 rs104894229 11:534289-534289 11:534289-534289
20 HRAS NM_005343.4(HRAS):c.35G>C (p.Gly12Ala)SNV Pathogenic 12603 rs104894230 11:534288-534288 11:534288-534288
21 HRAS NM_005343.4(HRAS):c.37G>T (p.Gly13Cys)SNV Pathogenic 12606 rs104894228 11:534286-534286 11:534286-534286
22 HRAS NM_005343.4(HRAS):c.34G>T (p.Gly12Cys)SNV Pathogenic 12613 rs104894229 11:534289-534289 11:534289-534289
23 FGFR2 NM_022970.3(FGFR2):c.755C>G (p.Ser252Trp)SNV Pathogenic 13272 rs79184941 10:123279677-123279677 10:121520163-121520163
24 PIK3CA NM_006218.4(PIK3CA):c.3140A>G (p.His1047Arg)SNV Pathogenic 13652 rs121913279 3:178952085-178952085 3:179234297-179234297
25 PIK3CA NM_006218.4(PIK3CA):c.3140A>T (p.His1047Leu)SNV Pathogenic 13653 rs121913279 3:178952085-178952085 3:179234297-179234297
26 TP53 NM_000546.5(TP53):c.818G>A (p.Arg273His)SNV Pathogenic 12366 rs28934576 17:7577120-7577120 17:7673802-7673802
27 NRAS NM_002524.5(NRAS):c.182A>G (p.Gln61Arg)SNV Pathogenic 13900 rs11554290 1:115256529-115256529 1:114713908-114713908
28 BRAF NM_004333.6(BRAF):c.1801A>G (p.Lys601Glu)SNV Pathogenic 13966 rs121913364 7:140453134-140453134 7:140753334-140753334
29 PIK3CA NM_006218.4(PIK3CA):c.1634A>C (p.Glu545Ala)SNV Pathogenic 13659 rs121913274 3:178936092-178936092 3:179218304-179218304
30 NRAS NM_002524.5(NRAS):c.35G>A (p.Gly12Asp)SNV Pathogenic 39648 rs121913237 1:115258747-115258747 1:114716126-114716126
31 PIK3CA NM_006218.4(PIK3CA):c.3139C>T (p.His1047Tyr)SNV Pathogenic 39705 rs121913281 3:178952084-178952084 3:179234296-179234296
32 NRAS NM_002524.5(NRAS):c.34G>T (p.Gly12Cys)SNV Pathogenic 40468 rs121913250 1:115258748-115258748 1:114716127-114716127
33 NRAS NM_002524.5(NRAS):c.34G>C (p.Gly12Arg)SNV Pathogenic 40469 rs121913250 1:115258748-115258748 1:114716127-114716127
34 NRAS NM_002524.5(NRAS):c.35G>T (p.Gly12Val)SNV Pathogenic 40470 rs121913237 1:115258747-115258747 1:114716126-114716126
35 PIK3CA NM_006218.4(PIK3CA):c.1258T>C (p.Cys420Arg)SNV Pathogenic 31945 rs121913272 3:178927980-178927980 3:179210192-179210192
36 PIK3CA NM_006218.4(PIK3CA):c.1637A>G (p.Gln546Arg)SNV Pathogenic 45466 rs397517201 3:178936095-178936095 3:179218307-179218307
37 TP53 NM_000546.5(TP53):c.659A>G (p.Tyr220Cys)SNV Pathogenic 127819 rs121912666 17:7578190-7578190 17:7674872-7674872
38 TP53 NM_000546.5(TP53):c.638G>A (p.Arg213Gln)SNV Pathogenic 135359 rs587778720 17:7578211-7578211 17:7674893-7674893
39 TP53 NM_000546.5(TP53):c.422G>A (p.Cys141Tyr)SNV Pathogenic 140801 rs587781288 17:7578508-7578508 17:7675190-7675190
40 TP53 NM_000546.5(TP53):c.844C>G (p.Arg282Gly)SNV Pathogenic 140821 rs28934574 17:7577094-7577094 17:7673776-7673776
41 TP53 NM_000546.5(TP53):c.842A>G (p.Asp281Gly)SNV Pathogenic 141141 rs587781525 17:7577096-7577096 17:7673778-7673778
42 TP53 NM_000546.5(TP53):c.833C>T (p.Pro278Leu)SNV Pathogenic 232497 rs876659802 17:7577105-7577105 17:7673787-7673787
43 TP53 NM_000546.5(TP53):c.743G>T (p.Arg248Leu)SNV Pathogenic 230253 rs11540652 17:7577538-7577538 17:7674220-7674220
44 NRAS NM_002524.5(NRAS):c.182A>C (p.Gln61Pro)SNV Pathogenic 280409 rs11554290 1:115256529-115256529 1:114713908-114713908
45 NRAS NM_002524.5(NRAS):c.183A>T (p.Gln61His)SNV Pathogenic 373003 rs121913255 1:115256528-115256528 1:114713907-114713907
46 PTEN NM_001304718.2(PTEN):c.-363C>GSNV Pathogenic 375958 rs121909224 10:89692904-89692904 10:87933147-87933147
47 MAP2K1 NM_002755.3(MAP2K1):c.370C>T (p.Pro124Ser)SNV Pathogenic/Likely pathogenic 375981 rs1057519732 15:66729162-66729162 15:66436824-66436824
48 ERBB2 NM_004448.3(ERBB2):c.2524G>A (p.Val842Ile)SNV Pathogenic/Likely pathogenic 375994 rs1057519738 17:37881332-37881332 17:39725079-39725079
49 NRAS NM_002524.5(NRAS):c.182A>T (p.Gln61Leu)SNV Pathogenic/Likely pathogenic 375874 rs11554290 1:115256529-115256529 1:114713908-114713908
50 CTNNB1 NM_001904.4(CTNNB1):c.110C>A (p.Ser37Tyr)SNV Pathogenic/Likely pathogenic 375894 rs121913403 3:41266113-41266113 3:41224622-41224622

Expression for Rare Cancer of Corpus Uteri

Search GEO for disease gene expression data for Rare Cancer of Corpus Uteri.

Pathways for Rare Cancer of Corpus Uteri

Pathways related to Rare Cancer of Corpus Uteri according to GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.71 TP53 PTEN PPP2R1A PIK3CA NRAS MTOR
2
Show member pathways
14.27 TP53 PTEN PPP2R1A PIK3CA NRAS MTOR
3
Show member pathways
14.13 TP53 PTEN PPP2R1A PIK3CA NRAS MTOR
4
Show member pathways
13.94 TP53 PTEN PPP2R1A NRAS MTOR MAP2K1
5
Show member pathways
13.91 TP53 PTEN NRAS MAP2K1 KRAS HRAS
6
Show member pathways
13.86 PPP2R1A PIK3CA NRAS MTOR MAP2K1 KRAS
7
Show member pathways
13.82 TP53 PPP2R1A NRAS MAP2K1 KRAS HRAS
8
Show member pathways
13.82 TP53 PPP2R1A NRAS MTOR MAP2K1 KRAS
9
Show member pathways
13.7 NRAS MTOR MAP2K1 KRAS HRAS FGFR2
10
Show member pathways
13.69 TP53 PPP2R1A PIK3CA NRAS MTOR MAP2K1
11
Show member pathways
13.67 PPP2R1A PIK3CA NRAS MAP2K1 KRAS HRAS
12
Show member pathways
13.62 TP53 PTEN PPP2R1A PIK3CA NRAS MTOR
13
Show member pathways
13.57 TP53 PTEN PPP2R1A NRAS MTOR KRAS
14
Show member pathways
13.54 PTEN PIK3CA NRAS MAP2K1 KRAS HRAS
15
Show member pathways
13.53 TP53 PPP2R1A PIK3CA NRAS MAP2K1 KRAS
16
Show member pathways
13.46 PPP2R1A NRAS MAP2K1 KRAS HRAS FGFR2
17
Show member pathways
13.45 PTEN NRAS MAP2K1 KRAS HRAS FGFR2
18
Show member pathways
13.43 PTEN NRAS KRAS HRAS FGFR2 ERBB2
19
Show member pathways
13.4 TP53 PTEN NRAS MTOR MAP2K1 KRAS
20
Show member pathways
13.39 TP53 PPP2R1A PIK3CA NRAS KRAS HRAS
21
Show member pathways
13.31 TP53 PPP2R1A PIK3CA NRAS MAP2K1 KRAS
22
Show member pathways
13.27 TP53 PTEN PPP2R1A PIK3CA MTOR FGFR2
23
Show member pathways
13.26 TP53 PTEN NRAS MTOR MAP2K1 KRAS
24
Show member pathways
13.22 PPP2R1A NRAS MTOR MAP2K1 KRAS HRAS
25
Show member pathways
13.17 TP53 NRAS MAP2K1 KRAS HRAS CTNNB1
26
Show member pathways
13.16 NRAS MAP2K1 KRAS HRAS CTNNB1 BRAF
27
Show member pathways
13.15 TP53 PTEN PIK3CA NRAS MTOR MAP2K1
28
Show member pathways
13.14 TP53 PIK3CA NRAS MTOR MAP2K1 KRAS
29
Show member pathways
13.13 PTEN PPP2R1A NRAS MAP2K1 KRAS HRAS
30
Show member pathways
13.11 PTEN PIK3CA NRAS MTOR MAP2K1 KRAS
31
Show member pathways
13.1 PTEN PIK3CA NRAS MAP2K1 KRAS HRAS
32
Show member pathways
13.07 PTEN PIK3CA NRAS MTOR MAP2K1 KRAS
33
Show member pathways
13.06 NRAS MAP2K1 KRAS HRAS CTNNB1 BRAF
34
Show member pathways
13.04 PIK3CA NRAS MAP2K1 KRAS HRAS BRAF
35
Show member pathways
13.03 PIK3CA NRAS MAP2K1 KRAS HRAS BRAF
36
Show member pathways
13.02 PPP2R1A NRAS MTOR MAP2K1 KRAS HRAS
37
Show member pathways
13.01 TP53 NRAS MAP2K1 KRAS HRAS
38
Show member pathways
13 PIK3CA NRAS MAP2K1 KRAS HRAS BRAF
39
Show member pathways
12.99 PTEN PIK3CA MTOR MAP2K1 KRAS HRAS
40
Show member pathways
12.98 TP53 PIK3CA NRAS MAP2K1 KRAS HRAS
41 12.98 TP53 NRAS MAP2K1 KRAS HRAS FGFR2
42
Show member pathways
12.97 PIK3CA NRAS KRAS HRAS FGFR2
43
Show member pathways
12.95 PIK3CA NRAS MAP2K1 KRAS HRAS FGFR2
44
Show member pathways
12.94 PPP2R1A PIK3CA NRAS MAP2K1 KRAS HRAS
45
Show member pathways
12.91 TP53 PTEN PPP2R1A PIK3CA NRAS MTOR
46
Show member pathways
12.89 TP53 PPP2R1A NRAS MAP2K1 KRAS HRAS
47
Show member pathways
12.87 PIK3CA NRAS MTOR MAP2K1 KRAS HRAS
48
Show member pathways
12.87 TP53 PTEN PPP2R1A PIK3CA NRAS MTOR
49
Show member pathways
12.86 PIK3CA NRAS MTOR MAP2K1 KRAS HRAS
50 12.86 PIK3CA NRAS MAP2K1 KRAS HRAS FGFR2

GO Terms for Rare Cancer of Corpus Uteri

Cellular components related to Rare Cancer of Corpus Uteri according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.1 TP53 PPP2R1A PIK3CA NRAS MTOR MAP2K1
2 plasma membrane GO:0005886 9.9 PTEN PPP2R1A PIK3CA NRAS MAP2K1 KRAS
3 mitochondrion GO:0005739 9.8 TP53 PTEN PPP2R1A MTOR MAP2K1 KRAS
4 cytosol GO:0005829 9.7 TP53 PTEN PPP2R1A PIK3CA MTOR MAP2K1
5 PML body GO:0016605 9.54 TP53 PTEN MTOR
6 postsynaptic cytosol GO:0099524 9.4 PTEN MTOR
7 cytoplasm GO:0005737 9.4 TP53 PTEN PPP2R1A PIK3CA MTOR MAP2K1

Biological processes related to Rare Cancer of Corpus Uteri according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 10.05 TP53 PTEN PPP2R1A HRAS FGFR2
2 phosphorylation GO:0016310 10.01 PIK3CA MTOR MAP2K1 FGFR2 ERBB2 BRAF
3 negative regulation of cell proliferation GO:0008285 9.99 TP53 PTEN MAP2K1 HRAS CTNNB1
4 protein phosphorylation GO:0006468 9.95 PIK3CA MTOR MAP2K1 FGFR2 ERBB2 BRAF
5 negative regulation of gene expression GO:0010629 9.93 TP53 MAP2K1 HRAS CTNNB1
6 positive regulation of protein phosphorylation GO:0001934 9.88 MTOR KRAS HRAS ERBB2
7 positive regulation of cell proliferation GO:0008284 9.88 PTEN KRAS HRAS FGFR2 ERBB2 CTNNB1
8 positive regulation of protein kinase B signaling GO:0051897 9.87 PIK3CA MTOR FGFR2 ERBB2
9 cellular response to hypoxia GO:0071456 9.86 TP53 PTEN MTOR
10 response to ethanol GO:0045471 9.85 TP53 PTEN FGFR2
11 negative regulation of neuron apoptotic process GO:0043524 9.85 PIK3CA KRAS HRAS BRAF
12 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.84 NRAS KRAS HRAS
13 peptidyl-tyrosine phosphorylation GO:0018108 9.83 MAP2K1 FGFR2 ERBB2 BRAF
14 cell cycle arrest GO:0007050 9.81 TP53 MTOR MAP2K1 HRAS
15 positive regulation of epithelial cell proliferation GO:0050679 9.79 HRAS FGFR2 ERBB2
16 positive regulation of MAP kinase activity GO:0043406 9.78 KRAS HRAS ERBB2
17 visual learning GO:0008542 9.77 MTOR KRAS BRAF
18 heart development GO:0007507 9.77 TP53 PTEN MAP2K1 ERBB2 CTNNB1
19 thymus development GO:0048538 9.76 MAP2K1 CTNNB1 BRAF
20 positive regulation of MAPK cascade GO:0043410 9.76 HRAS FGFR2 ERBB2 CTNNB1
21 wound healing GO:0042060 9.73 TP53 MTOR FGFR2 ERBB2
22 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.72 PTEN MAP2K1 HRAS FGFR2 BRAF
23 face development GO:0060324 9.69 MAP2K1 BRAF
24 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.68 TP53 PTEN
25 epithelial tube branching involved in lung morphogenesis GO:0060441 9.68 KRAS CTNNB1
26 regulation of osteoclast differentiation GO:0045670 9.68 MTOR CTNNB1
27 regulation of osteoblast differentiation GO:0045667 9.67 FGFR2 CTNNB1
28 cell aging GO:0007569 9.67 TP53 MTOR HRAS
29 regulation of synaptic transmission, GABAergic GO:0032228 9.66 PTEN KRAS
30 negative regulation of macroautophagy GO:0016242 9.66 PIK3CA MTOR
31 morphogenesis of embryonic epithelium GO:0016331 9.65 FGFR2 CTNNB1
32 anoikis GO:0043276 9.65 PIK3CA MTOR
33 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.64 TP53 MAP2K1
34 negative regulation of cell size GO:0045792 9.64 PTEN MTOR
35 lung-associated mesenchyme development GO:0060484 9.63 FGFR2 CTNNB1
36 trachea formation GO:0060440 9.62 MAP2K1 CTNNB1
37 response to isolation stress GO:0035900 9.62 KRAS HRAS
38 mesenchymal cell proliferation involved in lung development GO:0060916 9.56 FGFR2 CTNNB1
39 Ras protein signal transduction GO:0007265 9.56 TP53 NRAS KRAS HRAS
40 MAPK cascade GO:0000165 9.5 NRAS MAP2K1 KRAS HRAS FGFR2 ERBB2
41 regulation of axon regeneration GO:0048679 9.33 PTEN MAP2K1 BRAF
42 positive regulation of gene expression GO:0010628 9.28 TP53 PTEN MTOR MAP2K1 KRAS HRAS

Molecular functions related to Rare Cancer of Corpus Uteri according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.25 TP53 PTEN PPP2R1A PIK3CA NRAS MTOR
2 ATP binding GO:0005524 9.87 TP53 PIK3CA MTOR MAP2K1 FGFR2 ERBB2
3 protein serine/threonine kinase activity GO:0004674 9.78 PIK3CA MTOR MAP2K1 BRAF
4 protein kinase activity GO:0004672 9.77 MTOR MAP2K1 FGFR2 ERBB2 BRAF
5 kinase activity GO:0016301 9.73 PIK3CA MTOR MAP2K1 FGFR2 ERBB2 BRAF
6 protein phosphatase binding GO:0019903 9.63 TP53 ERBB2 CTNNB1
7 GDP binding GO:0019003 9.58 NRAS KRAS HRAS
8 protein tyrosine kinase activity GO:0004713 9.46 MAP2K1 FGFR2 ERBB2 BRAF
9 protein C-terminus binding GO:0008022 9.35 TP53 MAP2K1 HRAS ERBB2 CTNNB1
10 nucleotide binding GO:0000166 9.23 NRAS MTOR MAP2K1 KRAS HRAS FGFR2

Sources for Rare Cancer of Corpus Uteri

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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