MCID: RRD013
MIFTS: 32

Rare Diabetes Mellitus Type 2

Categories: Blood diseases, Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Rare Diabetes Mellitus Type 2

MalaCards integrated aliases for Rare Diabetes Mellitus Type 2:

Name: Rare Diabetes Mellitus Type 2 58
Rare Insulin-Independent Diabetes Mellitus 58

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

UMLS via Orphanet 72 C0011860
Orphanet 58 ORPHA181376

Summaries for Rare Diabetes Mellitus Type 2

MalaCards based summary : Rare Diabetes Mellitus Type 2, also known as rare insulin-independent diabetes mellitus, is related to maturity-onset diabetes of the young, type 14 and munchausen by proxy. An important gene associated with Rare Diabetes Mellitus Type 2 is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. Affiliated tissues include pancreas, and related phenotypes are growth/size/body region and endocrine/exocrine gland

Related Diseases for Rare Diabetes Mellitus Type 2

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Congenital Autoimmune Type 1 Diabetes Mellitus 2
Type 1 Diabetes Mellitus 3 Type 1 Diabetes Mellitus 4
Type 1 Diabetes Mellitus 5 Type 1 Diabetes Mellitus 6
Type 1 Diabetes Mellitus 7 Type 1 Diabetes Mellitus 8
Type 1 Diabetes Mellitus 10 Type 1 Diabetes Mellitus 11
Type 1 Diabetes Mellitus 12 Type 1 Diabetes Mellitus 13
Type 1 Diabetes Mellitus 15 Type 1 Diabetes Mellitus 17
Type 1 Diabetes Mellitus 18 Rare Diabetes Mellitus Type 1
Rare Diabetes Mellitus Type 2 Rare Diabetes Mellitus

Diseases related to Rare Diabetes Mellitus Type 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 maturity-onset diabetes of the young, type 14 10.3 HNF1A GCK
2 munchausen by proxy 10.2 KCNJ11 GCK ABCC8
3 hyperinsulinemic hypoglycemia, familial, 7 10.2 KCNJ11 GCK ABCC8
4 acute insulin response 10.1 KCNJ11 ABCC8
5 hyperinsulinemic hypoglycemia, familial, 2 10.1 KCNJ11 HNF4A ABCC8
6 hyperinsulinemic hypoglycemia, familial, 6 10.1 GCK ABCC8
7 diabetes mellitus, ketosis-prone 10.1 PAX4 KCNJ11 ABCC8
8 cardiomyopathy, dilated, 1o 10.1 SLC2A2 KCNJ11 ABCC8
9 insulin-like growth factor i 10.1 IRS1 INSR AKT2
10 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 10.0 WFS1 KCNJ11 ABCC8
11 donohue syndrome 10.0 KCNJ11 IRS1 INSR GCK
12 pancreatic agenesis 10.0 NEUROD1 KCNJ11 GCK ABCC8
13 cervical incompetence 9.9 MAPK8IP1 IL6
14 carbohydrate metabolic disorder 9.9 SLC2A2 KCNJ11 GCK ABCC8
15 pancreatic cystadenoma 9.9 SLC2A2 NEUROD1 GCK ABCC8
16 maturity-onset diabetes of the young, type 11 9.9 PAX4 NEUROD1 KCNJ11 ABCC8
17 contractures, pterygia, and variable skeletal fusions syndrome 1a 9.9 KCNJ11 HNF4A HNF1B HNF1A GCK
18 fanconi-bickel syndrome 9.8 SLC2A2 ABCC8
19 maturity-onset diabetes of the young, type 10 9.8 PAX4 NEUROD1 KCNJ11 GCK ABCC8
20 hyperinsulinemic hypoglycemia 9.7 KCNJ11 INSR HNF4A HNF1A GCK ABCC8
21 transient neonatal diabetes mellitus 9.7 SLC2A2 NEUROD1 KCNJ11 GCK ABCC8
22 lipid metabolism disorder 9.7 IRS1 INSR IL6 HNF4A
23 hyperinsulinism 9.7 KCNJ11 IRS1 INSR HNF4A GCK ABCC8
24 hypoglycemia 9.6 SLC2A2 KCNJ11 INSR GCK AKT2 ABCC8
25 acquired metabolic disease 9.6 SLC2A2 IRS1 IL6 GCK
26 maturity-onset diabetes of the young, type 13 9.6 PAX4 NEUROD1 KCNJ11 HNF4A GCK ABCC8
27 maturity-onset diabetes of the young, type 8, with exocrine dysfunction 9.6 PAX4 NEUROD1 KCNJ11 HNF4A GCK ABCC8
28 maturity-onset diabetes of the young, type 9 9.6 PAX4 NEUROD1 KCNJ11 HNF4A GCK ABCC8
29 monogenic diabetes 9.5 WFS1 KCNJ11 HNF4A HNF1B HNF1A GCK
30 wolfram syndrome 9.5 WFS1 KCNJ11 IGF2BP2
31 maturity-onset diabetes of the young, type 7 9.4 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B GCK
32 glucose metabolism disease 9.4 SLC2A2 KCNJ11 IRS1 IL6 GCK ABCC8
33 maturity-onset diabetes of the young, type 6 9.3 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B HNF1A
34 renal cysts and diabetes syndrome 9.3 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B HNF1A
35 insulinoma 9.2 WFS1 SLC2A2 PAX4 NEUROD1 HNF1A GCK
36 endocrine pancreas disease 9.2 SLC2A2 KCNJ11 IRS1 INSR IL6 GCK
37 maturity-onset diabetes of the young, type 4 9.0 SLC2A2 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B
38 maturity-onset diabetes of the young, type 3 9.0 SLC2A2 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B
39 maturity-onset diabetes of the young, type 1 9.0 SLC2A2 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B
40 diabetes mellitus, permanent neonatal 9.0 WFS1 SLC2A2 PAX4 NEUROD1 KCNJ11 HNF4A
41 neonatal diabetes mellitus 8.8 WFS1 SLC2A2 PAX4 NEUROD1 KCNJ11 HNF4A
42 maturity-onset diabetes of the young, type 2 8.7 WFS1 SLC2A2 PAX4 NEUROD1 KCNJ11 HNF4A
43 hyperglycemia 8.6 SLC2A2 PAX4 KCNJ11 IRS1 INSR IL6
44 diabetes mellitus, insulin-dependent 8.6 WFS1 SLC2A2 PAX4 NEUROD1 INSR IL6
45 glucose intolerance 8.6 KCNJ11 IRS1 INSR IL6 HNF1A GCK
46 gestational diabetes 8.4 KCNJ11 IRS1 INSR IL6 HNF4A HNF1A
47 body mass index quantitative trait locus 11 8.1 SLC2A2 KCNJ11 IRS1 INSR IL6 HNF4A
48 maturity-onset diabetes of the young 7.5 WFS1 SLC2A2 PAX4 NEUROD1 KCNJ11 IRS1
49 diabetes mellitus 6.0 WFS1 SLC2A2 PAX4 NEUROD1 MAPK8IP1 KCNJ11
50 diabetes mellitus, noninsulin-dependent 5.5 WFS1 SLC2A2 PAX4 NEUROD1 MAPK8IP1 KCNJ11

Graphical network of the top 20 diseases related to Rare Diabetes Mellitus Type 2:



Diseases related to Rare Diabetes Mellitus Type 2

Symptoms & Phenotypes for Rare Diabetes Mellitus Type 2

MGI Mouse Phenotypes related to Rare Diabetes Mellitus Type 2:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.32 AKT2 CAPN10 ENPP1 GCK GPD2 HNF1A
2 endocrine/exocrine gland MP:0005379 10.31 ABCC8 AKT2 CAPN10 GCK GPD2 HNF1A
3 homeostasis/metabolism MP:0005376 10.3 ABCC8 AKT2 CAPN10 ENPP1 GCK GPD2
4 behavior/neurological MP:0005386 10.23 ENPP1 GPD2 HNF1A IGF2BP2 IL6 INSR
5 adipose tissue MP:0005375 10.18 AKT2 CAPN10 ENPP1 GPD2 HNF1A IGF2BP2
6 cellular MP:0005384 10.17 AKT2 ENPP1 GCK HNF1A HNF4A IL6
7 liver/biliary system MP:0005370 10.1 AKT2 CAPN10 ENPP1 GCK GPD2 HNF1A
8 mortality/aging MP:0010768 10.09 AKT2 ENPP1 GCK GPD2 HNF1A HNF1B
9 muscle MP:0005369 9.61 AKT2 ENPP1 HNF1A HNF1B IL6 INSR
10 renal/urinary system MP:0005367 9.23 CAPN10 ENPP1 GCK HNF1A HNF1B IL6

Drugs & Therapeutics for Rare Diabetes Mellitus Type 2

Search Clinical Trials , NIH Clinical Center for Rare Diabetes Mellitus Type 2

Genetic Tests for Rare Diabetes Mellitus Type 2

Anatomical Context for Rare Diabetes Mellitus Type 2

MalaCards organs/tissues related to Rare Diabetes Mellitus Type 2:

40
Pancreas

Publications for Rare Diabetes Mellitus Type 2

Variations for Rare Diabetes Mellitus Type 2

ClinVar genetic disease variations for Rare Diabetes Mellitus Type 2:

6 (show top 50) (show all 155) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 SLC30A8 NM_001172813.2(SLC30A8):c.265C>T (p.Arg89Ter)SNV protective 141421 rs200185429 8:118165323-118165323 8:117153084-117153084
2 SLC30A8 NM_001172813.2(SLC30A8):c.-47_-41deldeletion protective 141422 rs587777582 8:118159221-118159227 8:117146982-117146988
3 PPARG NM_005037.5(PPARG):c.-2-29900A>GSNV association 440735 rs1553638903 3:12391303-12391303 3:12349804-12349804
4 PPARG NM_005037.5(PPARG):c.-2-29880A>TSNV association 440734 rs1553638909 3:12391323-12391323 3:12349824-12349824
5 PPARG NM_005037.5(PPARG):c.-2-28918A>CSNV association 440733 rs948820149 3:12392285-12392285 3:12350786-12350786
6 SLC2A2 NM_000340.2(SLC2A2):c.1331G>A (p.Trp444Ter)SNV Affects 444009 rs1553784995 3:170716025-170716025 3:170998236-170998236
7 SLC2A2 NM_000340.2(SLC2A2):c.963+1G>ASNV Pathogenic 444008 rs371977235 3:170723073-170723073 3:171005284-171005284
8 GCK NM_000162.5(GCK):c.544G>A (p.Val182Met)SNV Pathogenic 129144 rs587780345 7:44189603-44189603 7:44150004-44150004
9 GCK NM_000162.5(GCK):c.667G>A (p.Gly223Ser)SNV Pathogenic 435306 rs1360415315 7:44189371-44189371 7:44149772-44149772
10 HNF1A NM_000545.6(HNF1A):c.814C>T (p.Arg272Cys)SNV Pathogenic 447503 rs1555212014 12:121432067-121432067 12:120994264-120994264
11 KCNJ11 NM_000525.3(KCNJ11):c.967dup (p.Asp323fs)duplication Pathogenic 478917 rs1554901596 11:17408671-17408672 11:17387124-17387125
12 ABCC8 NM_001287174.2(ABCC8):c.221G>A (p.Arg74Gln)SNV Pathogenic 495834 rs72559734 11:17496502-17496502 11:17474955-17474955
13 WFS1 NM_006005.3(WFS1):c.330C>A (p.Tyr110Ter)SNV Pathogenic 523067 rs1553876668 4:6290728-6290728 4:6289001-6289001
14 GCK NM_000162.5(GCK):c.766G>A (p.Glu256Lys)SNV Pathogenic 265175 rs769268803 7:44187346-44187346 7:44147747-44147747
15 GPD2 NM_000408.5(GPD2):c.1904T>C (p.Phe635Ser)SNV Pathogenic 16081 rs121918407 2:157435621-157435621 2:156579109-156579109
16 IRS1 NM_005544.2(IRS1):c.2164_2166GGT[1] (p.Gly723del)short repeat Pathogenic 29760 rs1259467443 2:227661286-227661288 2:226796570-226796572
17 IRS1 NM_005544.2(IRS1):c.1823C>G (p.Thr608Arg)SNV Pathogenic 29762 rs104893642 2:227661632-227661632 2:226796916-226796916
18 PDX1 NM_000209.4(PDX1):c.492G>T (p.Glu164Asp)SNV Pathogenic,risk factor 8864 rs80356661 13:28498478-28498478 13:27924341-27924341
19 ABCC8 NM_001287174.2(ABCC8):c.4138C>T (p.Arg1380Cys)SNV Pathogenic 9105 rs137852673 11:17417462-17417462 11:17395915-17395915
20 ABCC8 NM_001287174.2(ABCC8):c.1744C>G (p.Leu582Val)SNV Pathogenic 9106 rs137852674 11:17452434-17452434 11:17430887-17430887
21 HNF1B NM_000458.4(HNF1B):c.1395C>G (p.Ser465Arg)SNV Pathogenic 12641 rs121918673 17:36061127-36061127 17:37701122-37701122
22 PAX4 NM_001366110.1(PAX4):c.385C>T (p.Arg129Trp)SNV Pathogenic 13790 rs114202595 7:127254587-127254587 7:127614533-127614533
23 AKT2 NM_001626.6(AKT2):c.821G>A (p.Arg274His)SNV Pathogenic 13982 rs121434593 19:40743886-40743886 19:40237979-40237979
24 INSR NM_000208.4(INSR):c.3572G>A (p.Arg1191Gln)SNV Pathogenic 14700 rs121913150 19:7120718-7120718 19:7120707-7120707
25 HNF1A NM_000545.6(HNF1A):c.1340C>T (p.Pro447Leu)SNV Pathogenic 14928 rs137853236 12:121435307-121435307 12:120997504-120997504
26 HNF4A NM_000457.4(HNF4A):c.253C>T (p.Arg85Trp)SNV Pathogenic 156152 rs587777732 20:43034835-43034835 20:44406195-44406195
27 MAPK8IP1 NM_005456.4(MAPK8IP1):c.176G>A (p.Ser59Asn)SNV Pathogenic 5419 rs119489103 11:45919710-45919710 11:45898159-45898159
28 NEUROD1 NM_002500.4(NEUROD1):c.332G>T (p.Arg111Leu)SNV Pathogenic 7853 rs104893649 2:182543256-182543256 2:181678529-181678529
29 KCNJ11 NM_000525.3(KCNJ11):c.844G>A (p.Glu282Lys)SNV Pathogenic/Likely pathogenic 8686 rs267607196 11:17408795-17408795 11:17387248-17387248
30 ABCC8 NM_001287174.2(ABCC8):c.2509C>T (p.Arg837Ter)SNV Pathogenic/Likely pathogenic 188915 rs72559722 11:17434263-17434263 11:17412716-17412716
31 ABCC8 NM_001287174.2(ABCC8):c.4309C>T (p.Arg1437Ter)SNV Pathogenic/Likely pathogenic 35617 rs193922402 11:17417158-17417158 11:17395611-17395611
32 GCK NM_000162.5(GCK):c.676G>A (p.Val226Met)SNV Pathogenic/Likely pathogenic 36243 rs148311934 7:44189362-44189362 7:44149763-44149763
33 ABCC8 NM_001287174.2(ABCC8):c.4435G>A (p.Gly1479Arg)SNV Pathogenic/Likely pathogenic 434045 rs72559715 11:17415926-17415926 11:17394379-17394379
34 HNF1A NM_000545.6(HNF1A):c.1135C>G (p.Pro379Ala)SNV Pathogenic/Likely pathogenic 431970 rs754729248 12:121434371-121434371 12:120996568-120996568
35 WRN NM_000553.5(WRN):c.724+1G>TSNV Likely pathogenic 523380 rs1339616347 8:30925844-30925844 8:31068328-31068328
36 RBPJ NM_005349.3(RBPJ):c.193A>G (p.Arg65Gly)SNV Likely pathogenic 523586 rs1553878211 4:26407891-26407891 4:26406269-26406269
37 IRS1 NM_005544.2(IRS1):c.158G>A (p.Trp53Ter)SNV Likely pathogenic 804395 2:227663297-227663297 2:226798581-226798581
38 ABCC8 NM_001287174.2(ABCC8):c.290+2T>CSNV Likely pathogenic 552247 rs1554948310 11:17496431-17496431 11:17474884-17474884
39 RBPJL NC_000020.10:g.43914005C>GSNV risk factor 444105 rs76474829 20:43914005-43914005 20:45285365-45285365
40 RBPJL NM_014276.4(RBPJL):c.839C>T (p.Thr280Met)SNV risk factor 445144 rs200998587 20:43942756-43942756 20:45314116-45314116
41 GCK NM_000162.5(GCK):c.1358C>T (p.Ser453Leu)SNV Likely pathogenic 36200 rs193922283 7:44184775-44184775 7:44145176-44145176
42 HMGA1 HMGA1, 1-BP INS, IVS5, -13insertion risk factor 30122
43 IL6 IL6, -174G-CSNV risk factor 14718
44 HNF1A NM_000545.6(HNF1A):c.955G>A (p.Gly319Ser)SNV risk factor 14934 rs137853240 12:121432208-121432208 12:120994405-120994405
45 LIPC NM_000236.2(LIPC):c.-293G>ASNV risk factor 14454 rs2070895 15:58723939-58723939 15:58431740-58431740
46 ENPP1 ENPP1, IVS20AS, 1-BP DEL, T, -11deletion risk factor 13584
47 PDX1 NM_000209.4(PDX1):c.176A>T (p.Gln59Leu)SNV risk factor 8860 rs137852784 13:28494451-28494451 13:27920314-27920314
48 PDX1 PDX1, 3-BP INS, 243CCGinsertion risk factor 8861
49 PDX1 NM_000209.4(PDX1):c.52T>C (p.Cys18Arg)SNV Likely pathogenic 8862 rs137852785 13:28494327-28494327 13:27920190-27920190
50 PDX1 NM_000209.4(PDX1):c.590G>A (p.Arg197His)SNV risk factor 8858 rs137852786 13:28498576-28498576 13:27924439-27924439

Expression for Rare Diabetes Mellitus Type 2

Search GEO for disease gene expression data for Rare Diabetes Mellitus Type 2.

Pathways for Rare Diabetes Mellitus Type 2

Pathways related to Rare Diabetes Mellitus Type 2 according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 MAPK8IP1 IRS1 INSR IL6 HNF4A HNF1B
2
Show member pathways
13.42 MAPK8IP1 IRS1 INSR IL6 HNF4A HNF1B
3
Show member pathways
13.36 SLC2A2 PAX4 NEUROD1 IRS1 HNF4A HNF1B
4
Show member pathways
12.41 IRS1 INSR ENPP1 AKT2
5 12.41 WFS1 NEUROD1 IRS1 INSR HNF4A HNF1A
6
Show member pathways
12.36 SLC2A2 IRS1 GCK AKT2
7
Show member pathways
12.34 HNF4A HNF1B HNF1A AKT2
8
Show member pathways
12.31 IRS1 INSR HNF4A AKT2
9 12.3 HNF4A HNF1B HNF1A AKT2
10
Show member pathways
11.96 IRS1 INSR IL6 AKT2
11 11.93 IRS1 IL6 HNF1A HMGA1
12 11.93 SLC2A2 PAX4 NEUROD1 IL6 HNF1B
13
Show member pathways
11.89 SLC2A2 NEUROD1 INSR HNF4A HNF1B HNF1A
14 11.87 IRS1 INSR AKT2
15 11.84 INSR IL6 AKT2
16 11.82 SLC2A2 GCK AKT2
17
Show member pathways
11.81 SLC2A2 IRS1 INSR IL6 AKT2
18 11.58 SLC2A2 GCK AKT2
19
Show member pathways
11.56 SLC2A2 PAX4 NEUROD1 HNF4A HNF1B HNF1A
20 11.46 IRS1 INSR AKT2
21 11.45 KCNJ11 IRS1 AKT2 ABCC8
22 11.35 IRS1 INSR AKT2
23
Show member pathways
11.3 SLC2A2 NEUROD1 KCNJ11 IRS1 INSR HNF4A
24 11.28 SLC2A2 KCNJ11 HNF4A HNF1A GCK ABCC8
25 11 IRS1 INSR IL6
26
Show member pathways
10.84 IRS1 INSR AKT2
27 10.46 HNF4A HNF1A

GO Terms for Rare Diabetes Mellitus Type 2

Cellular components related to Rare Diabetes Mellitus Type 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor complex GO:0005899 8.96 IRS1 INSR
2 inward rectifying potassium channel GO:0008282 8.62 KCNJ11 ABCC8

Biological processes related to Rare Diabetes Mellitus Type 2 according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.02 PAX4 MAPK8IP1 IL6 HNF1B AKT2
2 positive regulation of transcription, DNA-templated GO:0045893 9.98 NEUROD1 INSR IL6 HNF4A HNF1B HNF1A
3 response to drug GO:0042493 9.92 PAX4 NEUROD1 KCNJ11 HNF1B ABCC8
4 carbohydrate metabolic process GO:0005975 9.9 SLC2A2 INSR GCK AKT2
5 insulin receptor signaling pathway GO:0008286 9.78 IRS1 INSR AKT2
6 response to glucose GO:0009749 9.76 NEUROD1 HNF4A HNF1B HNF1A
7 glucose metabolic process GO:0006006 9.74 KCNJ11 GCK AKT2
8 positive regulation of glucose import GO:0046326 9.71 IRS1 INSR CAPN10 AKT2
9 insulin secretion GO:0030073 9.69 NEUROD1 HNF1B HNF1A
10 negative regulation of insulin secretion GO:0046676 9.67 KCNJ11 IRS1 ABCC8
11 pancreas development GO:0031016 9.67 WFS1 PAX4 HNF1B HNF1A
12 cellular response to insulin stimulus GO:0032869 9.63 IRS1 INSR GCK ENPP1 CAPN10 AKT2
13 endocrine pancreas development GO:0031018 9.62 PAX4 NEUROD1 IL6 HNF1A
14 hepatocyte differentiation GO:0070365 9.61 HNF4A HNF1B
15 positive regulation of fatty acid beta-oxidation GO:0032000 9.59 IRS1 AKT2
16 positive regulation of glucose metabolic process GO:0010907 9.58 IRS1 AKT2
17 positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 9.58 HNF1B HNF1A
18 regulation of cell cycle arrest GO:0071156 9.56 NEUROD1 AKT2
19 positive regulation of glycogen biosynthetic process GO:0045725 9.56 IRS1 INSR GCK AKT2
20 negative regulation of type B pancreatic cell apoptotic process GO:2000675 9.55 WFS1 NEUROD1
21 positive regulation of type B pancreatic cell apoptotic process GO:2000676 9.54 IL6 CAPN10
22 regulation of pronephros size GO:0035565 9.48 HNF1B HNF1A
23 regulation of insulin secretion GO:0050796 9.43 SLC2A2 NEUROD1 KCNJ11 HNF4A GCK ABCC8
24 glucose homeostasis GO:0042593 9.17 WFS1 NEUROD1 IRS1 INSR HNF4A HNF1A

Molecular functions related to Rare Diabetes Mellitus Type 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.43 PAX4 NEUROD1 HNF4A HNF1B HNF1A HMGA1
2 insulin-like growth factor receptor binding GO:0005159 8.62 IRS1 INSR

Sources for Rare Diabetes Mellitus Type 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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