MCID: RRD013
MIFTS: 31

Rare Diabetes Mellitus Type 2

Categories: Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Rare Diabetes Mellitus Type 2

MalaCards integrated aliases for Rare Diabetes Mellitus Type 2:

Name: Rare Diabetes Mellitus Type 2 58
Rare Insulin-Independent Diabetes Mellitus 58

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

UMLS via Orphanet 72 C0011860
Orphanet 58 ORPHA181376

Summaries for Rare Diabetes Mellitus Type 2

MalaCards based summary : Rare Diabetes Mellitus Type 2, also known as rare insulin-independent diabetes mellitus, is related to rare genetic diabetes mellitus and type 1 diabetes mellitus 11. An important gene associated with Rare Diabetes Mellitus Type 2 is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Rare Diabetes Mellitus Type 2

Diseases in the Diabetes Mellitus family:

Diabetes Mellitus, Type I Diabetes Mellitus, Congenital Autoimmune
Type 1 Diabetes Mellitus 2 Type 1 Diabetes Mellitus 3
Type 1 Diabetes Mellitus 4 Type 1 Diabetes Mellitus 5
Type 1 Diabetes Mellitus 6 Type 1 Diabetes Mellitus 7
Type 1 Diabetes Mellitus 8 Type 1 Diabetes Mellitus 10
Type 1 Diabetes Mellitus 11 Type 1 Diabetes Mellitus 12
Type 1 Diabetes Mellitus 13 Type 1 Diabetes Mellitus 15
Type 1 Diabetes Mellitus 17 Type 1 Diabetes Mellitus 18
Rare Diabetes Mellitus Type 1 Rare Diabetes Mellitus Type 2
Rare Diabetes Mellitus

Diseases related to Rare Diabetes Mellitus Type 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 rare genetic diabetes mellitus 10.4 HNF1A GCK
2 type 1 diabetes mellitus 11 10.3 NEUROD1 HNF1A
3 acute insulin response 10.3 KCNJ11 ABCC8
4 munchausen by proxy 10.2 KCNJ11 GCK ABCC8
5 hyperinsulinemic hypoglycemia, familial, 7 10.2 KCNJ11 GCK ABCC8
6 hyperinsulinemic hypoglycemia, familial, 6 10.2 GCK ABCC8
7 donohue syndrome 10.2 IRS1 INSR GCK
8 hyperinsulinemic hypoglycemia, familial, 2 10.1 KCNJ11 HNF4A ABCC8
9 diabetes mellitus, permanent neonatal 1 10.1 KCNJ11 GCK ABCC8
10 diabetes mellitus, ketosis-prone 10.1 PAX4 KCNJ11 ABCC8
11 insulin-like growth factor i 10.1 IRS1 INSR AKT2
12 fructose-1,6-bisphosphatase deficiency 10.1 GCK ABCC8
13 cardiomyopathy, dilated, 1o 10.1 SLC2A2 KCNJ11 ABCC8
14 maturity-onset diabetes of the young, type 14 10.1 PAX4 NEUROD1 GCK
15 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 10.1 WFS1 KCNJ11 ABCC8
16 fanconi-bickel syndrome 10.0 SLC2A2 ABCC8
17 asphyxia neonatorum 10.0 KCNJ11 IL6 ABCC8
18 cervical incompetence 10.0 MAPK8IP1 IL6
19 hepatic adenomas, familial 9.9 HNF4A HNF1A
20 pancreatic cystadenoma 9.9 SLC2A2 NEUROD1 GCK ABCC8
21 maturity-onset diabetes of the young, type 11 9.9 PAX4 NEUROD1 KCNJ11 ABCC8
22 maturity-onset diabetes of the young, type 10 9.9 PAX4 NEUROD1 KCNJ11 ABCC8
23 pancreatic agenesis 9.8 NEUROD1 KCNJ11 HNF1B GCK ABCC8
24 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 9.8 IL6 HNF4A HNF1A GCK
25 non-alcoholic steatohepatitis 9.8 IRS1 IL6 HNF4A
26 hyperinsulinemic hypoglycemia 9.8 KCNJ11 INSR HNF4A HNF1A GCK ABCC8
27 diabetes mellitus, permanent neonatal 4 9.7 SLC2A2 NEUROD1 KCNJ11 GCK ABCC8
28 lipid metabolism disorder 9.7 IRS1 INSR IL6 HNF4A
29 transient neonatal diabetes mellitus 9.7 SLC2A2 NEUROD1 KCNJ11 GCK ABCC8
30 hyperinsulinism 9.7 KCNJ11 IRS1 INSR HNF4A GCK ABCC8
31 hypoglycemia 9.6 SLC2A2 KCNJ11 INSR GCK AKT2 ABCC8
32 wolfram syndrome 1 9.6 WFS1 KCNJ11 IGF2BP2
33 wolfram syndrome 9.6 WFS1 KCNJ11 IGF2BP2
34 glucose metabolism disease 9.5 SLC2A2 KCNJ11 IRS1 IL6 GCK
35 maturity-onset diabetes of the young, type 13 9.5 PAX4 NEUROD1 KCNJ11 HNF4A HNF1A GCK
36 monogenic diabetes 9.5 WFS1 KCNJ11 HNF4A HNF1B HNF1A GCK
37 maturity-onset diabetes of the young, type 9 9.4 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B GCK
38 maturity-onset diabetes of the young, type 7 9.4 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B GCK
39 maturity-onset diabetes of the young, type 8, with exocrine dysfunction 9.3 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B HNF1A
40 maturity-onset diabetes of the young, type 6 9.3 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B HNF1A
41 renal cysts and diabetes syndrome 9.3 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B HNF1A
42 insulinoma 9.3 WFS1 SLC2A2 PAX4 NEUROD1 HNF1A GCK
43 maturity-onset diabetes of the young, type 1 9.0 SLC2A2 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B
44 maturity-onset diabetes of the young, type 4 9.0 SLC2A2 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B
45 maturity-onset diabetes of the young, type 3 9.0 SLC2A2 PAX4 NEUROD1 KCNJ11 HNF4A HNF1B
46 neonatal diabetes mellitus 8.7 WFS1 SLC2A2 PAX4 NEUROD1 KCNJ11 HNF4A
47 maturity-onset diabetes of the young, type 2 8.7 WFS1 SLC2A2 PAX4 NEUROD1 KCNJ11 HNF4A
48 diabetes mellitus, type i 8.6 WFS1 SLC2A2 PAX4 NEUROD1 INSR IL6
49 hyperglycemia 8.6 SLC2A2 PAX4 KCNJ11 IRS1 INSR IL6
50 glucose intolerance 8.6 KCNJ11 IRS1 INSR IL6 HNF1A GCK

Graphical network of the top 20 diseases related to Rare Diabetes Mellitus Type 2:



Diseases related to Rare Diabetes Mellitus Type 2

Symptoms & Phenotypes for Rare Diabetes Mellitus Type 2

GenomeRNAi Phenotypes related to Rare Diabetes Mellitus Type 2 according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.88 GPD2 SLC2A2
2 Decreased viability GR00173-A 9.88 MAPK8IP1
3 Decreased viability GR00221-A-1 9.88 AKT2 GCK INSR IRS1
4 Decreased viability GR00221-A-2 9.88 GCK INSR IRS1
5 Decreased viability GR00221-A-3 9.88 AKT2 GCK INSR
6 Decreased viability GR00221-A-4 9.88 AKT2 GCK INSR MAPK8IP1
7 Decreased viability GR00249-S 9.88 ENPP1 HMGA1 HNF1B
8 Decreased viability GR00301-A 9.88 AKT2 MAPK8IP1
9 Decreased viability GR00342-S-2 9.88 IRS1
10 Decreased viability GR00342-S-3 9.88 AKT2 IRS1 MAPK8IP1
11 Decreased viability GR00386-A-1 9.88 HNF1B HNF4A IRS1 MAPK8IP1 PAX4 SLC2A2
12 Decreased viability GR00402-S-2 9.88 CAPN10 ENPP1 MAPK8IP1 SLC2A2

MGI Mouse Phenotypes related to Rare Diabetes Mellitus Type 2:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.35 AKT2 CAPN10 ENPP1 GCK GPD2 HMGA1
2 endocrine/exocrine gland MP:0005379 10.33 ABCC8 AKT2 CAPN10 GCK GPD2 HMGA1
3 behavior/neurological MP:0005386 10.32 CAPN10 ENPP1 GPD2 HNF1A HNF4A IGF2BP2
4 homeostasis/metabolism MP:0005376 10.32 ABCC8 AKT2 CAPN10 ENPP1 GCK GPD2
5 cellular MP:0005384 10.21 AKT2 ENPP1 GCK HNF1A HNF1B HNF4A
6 adipose tissue MP:0005375 10.19 AKT2 CAPN10 ENPP1 GPD2 HNF1A IGF2BP2
7 cardiovascular system MP:0005385 10.16 CAPN10 ENPP1 GCK HMGA1 HNF4A IL6
8 mortality/aging MP:0010768 10.11 AKT2 ENPP1 GCK GPD2 HMGA1 HNF1A
9 liver/biliary system MP:0005370 10.1 AKT2 CAPN10 ENPP1 GCK GPD2 HNF1A
10 muscle MP:0005369 9.61 AKT2 ENPP1 HNF1A HNF1B IL6 INSR
11 renal/urinary system MP:0005367 9.28 CAPN10 ENPP1 GCK HNF1A HNF1B HNF4A

Drugs & Therapeutics for Rare Diabetes Mellitus Type 2

Search Clinical Trials , NIH Clinical Center for Rare Diabetes Mellitus Type 2

Genetic Tests for Rare Diabetes Mellitus Type 2

Anatomical Context for Rare Diabetes Mellitus Type 2

Publications for Rare Diabetes Mellitus Type 2

Variations for Rare Diabetes Mellitus Type 2

ClinVar genetic disease variations for Rare Diabetes Mellitus Type 2:

6 (show top 50) (show all 172) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 PPARG NM_005037.5(PPARG):c.-2-29900A>GSNV association 440735 rs1553638903 3:12391303-12391303 3:12349804-12349804
2 PPARG NM_005037.5(PPARG):c.-2-29880A>TSNV association 440734 rs1553638909 3:12391323-12391323 3:12349824-12349824
3 PPARG NM_005037.5(PPARG):c.-2-28918A>CSNV association 440733 rs948820149 3:12392285-12392285 3:12350786-12350786
4 SLC2A2 NM_000340.2(SLC2A2):c.1331G>A (p.Trp444Ter)SNV Affects 444009 rs1553784995 3:170716025-170716025 3:170998236-170998236
5 SLC30A8 NM_001172813.2(SLC30A8):c.265C>T (p.Arg89Ter)SNV protective 141421 rs200185429 8:118165323-118165323 8:117153084-117153084
6 SLC30A8 NM_001172813.2(SLC30A8):c.-47_-41deldeletion protective 141422 rs587777582 8:118159221-118159227 8:117146982-117146988
7 HNF4A NM_175914.4(HNF4A):c.187C>T (p.Arg63Trp)SNV Pathogenic 156152 rs587777732 20:43034835-43034835 20:44406195-44406195
8 GCK NM_000162.5(GCK):c.544G>A (p.Val182Met)SNV Pathogenic 129144 rs587780345 7:44189603-44189603 7:44150004-44150004
9 PAX4 NM_001366110.1(PAX4):c.385C>T (p.Arg129Trp)SNV Pathogenic 13790 rs114202595 7:127254587-127254587 7:127614533-127614533
10 AKT2 NM_001626.6(AKT2):c.821G>A (p.Arg274His)SNV Pathogenic 13982 rs121434593 19:40743886-40743886 19:40237979-40237979
11 INSR NM_000208.4(INSR):c.3572G>A (p.Arg1191Gln)SNV Pathogenic 14700 rs121913150 19:7120718-7120718 19:7120707-7120707
12 GPD2 NM_000408.5(GPD2):c.1904T>C (p.Phe635Ser)SNV Pathogenic 16081 rs121918407 2:157435621-157435621 2:156579109-156579109
13 IRS1 NM_005544.2(IRS1):c.2164_2166GGT[1] (p.Gly723del)short repeat Pathogenic 29760 rs1259467443 2:227661286-227661288 2:226796570-226796572
14 IRS1 NM_005544.2(IRS1):c.1823C>G (p.Thr608Arg)SNV Pathogenic 29762 rs104893642 2:227661632-227661632 2:226796916-226796916
15 HNF1A NM_000545.6(HNF1A):c.1340C>T (p.Pro447Leu)SNV Pathogenic 14928 rs137853236 12:121435307-121435307 12:120997504-120997504
16 MAPK8IP1 NM_005456.4(MAPK8IP1):c.176G>A (p.Ser59Asn)SNV Pathogenic 5419 rs119489103 11:45919710-45919710 11:45898159-45898159
17 NEUROD1 NM_002500.4(NEUROD1):c.332G>T (p.Arg111Leu)SNV Pathogenic 7853 rs104893649 2:182543256-182543256 2:181678529-181678529
18 PDX1 NM_000209.4(PDX1):c.492G>T (p.Glu164Asp)SNV Pathogenic,risk factor 8864 rs80356661 13:28498478-28498478 13:27924341-27924341
19 ABCC8 NM_000352.6(ABCC8):c.4135C>T (p.Arg1379Cys)SNV Pathogenic 9105 rs137852673 11:17417462-17417462 11:17395915-17395915
20 ABCC8 NM_000352.6(ABCC8):c.1744C>G (p.Leu582Val)SNV Pathogenic 9106 rs137852674 11:17452434-17452434 11:17430887-17430887
21 GCK NM_000162.5(GCK):c.667G>A (p.Gly223Ser)SNV Pathogenic 435306 rs1360415315 7:44189371-44189371 7:44149772-44149772
22 SLC2A2 NM_000340.2(SLC2A2):c.963+1G>ASNV Pathogenic 444008 rs371977235 3:170723073-170723073 3:171005284-171005284
23 HNF1A NM_000545.6(HNF1A):c.814C>T (p.Arg272Cys)SNV Pathogenic 447503 rs1555212014 12:121432067-121432067 12:120994264-120994264
24 KCNJ11 NM_000525.3(KCNJ11):c.967dup (p.Asp323fs)duplication Pathogenic 478917 rs1554901596 11:17408671-17408672 11:17387124-17387125
25 ABCC8 NM_000352.6(ABCC8):c.221G>A (p.Arg74Gln)SNV Pathogenic 495834 rs72559734 11:17496502-17496502 11:17474955-17474955
26 WFS1 NM_006005.3(WFS1):c.330C>A (p.Tyr110Ter)SNV Pathogenic 523067 rs1553876668 4:6290728-6290728 4:6289001-6289001
27 HNF1B NM_000458.4(HNF1B):c.232G>T (p.Glu78Ter)SNV Pathogenic 635724 17:36104644-36104644 17:37744653-37744653
28 GCK NM_000162.5(GCK):c.766G>A (p.Glu256Lys)SNV Pathogenic 265175 rs769268803 7:44187346-44187346 7:44147747-44147747
29 ABCC8 NM_000352.6(ABCC8):c.4432G>A (p.Gly1478Arg)SNV Pathogenic/Likely pathogenic 434045 rs72559715 11:17415926-17415926 11:17394379-17394379
30 KCNJ11 NM_000525.3(KCNJ11):c.844G>A (p.Glu282Lys)SNV Pathogenic/Likely pathogenic 8686 rs267607196 11:17408795-17408795 11:17387248-17387248
31 ABCC8 NM_000352.6(ABCC8):c.4306C>T (p.Arg1436Ter)SNV Pathogenic/Likely pathogenic 35617 rs193922402 11:17417158-17417158 11:17395611-17395611
32 ABCC8 NM_000352.6(ABCC8):c.2506C>T (p.Arg836Ter)SNV Pathogenic/Likely pathogenic 188915 rs72559722 11:17434263-17434263 11:17412716-17412716
33 GCK NM_000162.5(GCK):c.676G>A (p.Val226Met)SNV Pathogenic/Likely pathogenic 36243 rs148311934 7:44189362-44189362 7:44149763-44149763
34 IL6 IL6, -174G-CSNV risk factor 14718
35 GCK NM_000162.5(GCK):c.1358C>T (p.Ser453Leu)SNV Likely pathogenic 36200 rs193922283 7:44184775-44184775 7:44145176-44145176
36 HNF1A NM_000545.6(HNF1A):c.955G>A (p.Gly319Ser)SNV risk factor 14934 rs137853240 12:121432208-121432208 12:120994405-120994405
37 HMGA1 HMGA1, 1-BP INS, IVS5, -13insertion risk factor 30122
38 LIPC NM_000236.2(LIPC):c.-293G>ASNV risk factor 14454 rs2070895 15:58723939-58723939 15:58431740-58431740
39 PDX1 NM_000209.4(PDX1):c.590G>A (p.Arg197His)SNV risk factor 8858 rs137852786 13:28498576-28498576 13:27924439-27924439
40 PDX1 NM_000209.4(PDX1):c.176A>T (p.Gln59Leu)SNV risk factor 8860 rs137852784 13:28494451-28494451 13:27920314-27920314
41 PDX1 PDX1, 3-BP INS, 243CCGinsertion risk factor 8861
42 PDX1 NM_000209.4(PDX1):c.52T>C (p.Cys18Arg)SNV Likely pathogenic 8862 rs137852785 13:28494327-28494327 13:27920190-27920190
43 ABCC8 , KCNJ11 NM_000525.3(KCNJ11):c.67A>G (p.Lys23Glu)SNV drug response 8678 rs5219 11:17409572-17409572 11:17388025-17388025
44 HNF1A NM_000545.8(HNF1A):c.43G>T (p.Ala15Ser)SNV Likely pathogenic 915441 12:121416614-121416614 12:120978811-120978811
45 ENPP1 ENPP1, IVS20AS, 1-BP DEL, T, -11deletion risk factor 13584
46 TCF7L2 NM_001146274.2(TCF7L2):c.450+33966C>TSNV drug response 7413 rs7903146 10:114758349-114758349 10:112998590-112998590
47 TCF7L2 NM_001146274.2(TCF7L2):c.552+9017G>TSNV risk factor 7414 rs12255372 10:114808902-114808902 10:113049143-113049143
48 TCF7L2 NM_001146274.2(TCF7L2):c.552+7162G>CSNV risk factor 7415 rs11196205 10:114807047-114807047 10:113047288-113047288
49 IGF2BP2 NM_006548.6(IGF2BP2):c.239+29254C>ASNV risk factor 2435 rs4402960 3:185511687-185511687 3:185793899-185793899
50 RETN RETN, +62G-ASNV risk factor 4884

Expression for Rare Diabetes Mellitus Type 2

Search GEO for disease gene expression data for Rare Diabetes Mellitus Type 2.

Pathways for Rare Diabetes Mellitus Type 2

Pathways related to Rare Diabetes Mellitus Type 2 according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 MAPK8IP1 IRS1 INSR IL6 HNF4A HNF1B
2
Show member pathways
13.42 MAPK8IP1 IRS1 INSR IL6 HNF4A HNF1B
3
Show member pathways
13.36 SLC2A2 PAX4 NEUROD1 IRS1 HNF4A HNF1B
4
Show member pathways
12.41 IRS1 INSR ENPP1 AKT2
5 12.41 WFS1 NEUROD1 IRS1 INSR HNF4A HNF1A
6
Show member pathways
12.37 IRS1 INSR HNF4A AKT2
7
Show member pathways
12.36 SLC2A2 IRS1 GCK AKT2
8
Show member pathways
12.34 HNF4A HNF1B HNF1A AKT2
9 12.3 HNF4A HNF1B HNF1A AKT2
10
Show member pathways
12.12 MAPK8IP1 IRS1 INSR AKT2
11
Show member pathways
11.96 IRS1 INSR IL6 AKT2
12 11.93 IRS1 IL6 HNF1A HMGA1
13 11.93 SLC2A2 PAX4 NEUROD1 IL6 HNF1B
14
Show member pathways
11.89 SLC2A2 NEUROD1 INSR HNF4A HNF1B HNF1A
15 11.87 IRS1 INSR AKT2
16 11.84 INSR IL6 AKT2
17 11.82 SLC2A2 GCK AKT2
18
Show member pathways
11.81 SLC2A2 IRS1 INSR IL6 AKT2
19 11.59 SLC2A2 GCK AKT2
20
Show member pathways
11.56 SLC2A2 PAX4 NEUROD1 HNF4A HNF1B HNF1A
21 11.47 IRS1 INSR AKT2
22 11.45 KCNJ11 IRS1 AKT2 ABCC8
23 11.35 IRS1 INSR AKT2
24
Show member pathways
11.3 SLC2A2 NEUROD1 KCNJ11 IRS1 INSR HNF4A
25 11.28 SLC2A2 KCNJ11 HNF4A HNF1A GCK ABCC8
26 11 IRS1 INSR IL6
27
Show member pathways
10.84 IRS1 INSR AKT2
28 10.46 HNF4A HNF1A

GO Terms for Rare Diabetes Mellitus Type 2

Cellular components related to Rare Diabetes Mellitus Type 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor complex GO:0005899 8.96 IRS1 INSR
2 inward rectifying potassium channel GO:0008282 8.62 KCNJ11 ABCC8

Biological processes related to Rare Diabetes Mellitus Type 2 according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.02 PAX4 MAPK8IP1 IL6 HNF1B AKT2
2 positive regulation of transcription, DNA-templated GO:0045893 10 NEUROD1 INSR IL6 HNF4A HNF1B HNF1A
3 response to drug GO:0042493 9.93 PAX4 NEUROD1 KCNJ11 HNF1B ABCC8
4 carbohydrate metabolic process GO:0005975 9.88 SLC2A2 INSR GCK AKT2
5 insulin receptor signaling pathway GO:0008286 9.78 IRS1 INSR AKT2
6 glucose metabolic process GO:0006006 9.74 KCNJ11 GCK AKT2
7 response to glucose GO:0009749 9.73 NEUROD1 HNF4A HNF1B HNF1A
8 positive regulation of glucose import GO:0046326 9.71 IRS1 INSR CAPN10 AKT2
9 insulin secretion GO:0030073 9.69 NEUROD1 HNF1B HNF1A
10 negative regulation of insulin secretion GO:0046676 9.67 KCNJ11 IRS1 ABCC8
11 pancreas development GO:0031016 9.67 WFS1 PAX4 HNF1B HNF1A
12 cellular response to insulin stimulus GO:0032869 9.63 IRS1 INSR GCK ENPP1 CAPN10 AKT2
13 positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 9.62 HNF1B HNF1A
14 endocrine pancreas development GO:0031018 9.62 PAX4 NEUROD1 IL6 HNF1A
15 hepatocyte differentiation GO:0070365 9.61 HNF4A HNF1B
16 positive regulation of fatty acid beta-oxidation GO:0032000 9.6 IRS1 AKT2
17 positive regulation of glucose metabolic process GO:0010907 9.59 IRS1 AKT2
18 inorganic cation transmembrane transport GO:0098662 9.58 KCNJ11 ABCC8
19 regulation of cell cycle arrest GO:0071156 9.56 NEUROD1 AKT2
20 positive regulation of glycogen biosynthetic process GO:0045725 9.56 IRS1 INSR GCK AKT2
21 negative regulation of type B pancreatic cell apoptotic process GO:2000675 9.55 WFS1 NEUROD1
22 positive regulation of type B pancreatic cell apoptotic process GO:2000676 9.52 IL6 CAPN10
23 regulation of pronephros size GO:0035565 9.48 HNF1B HNF1A
24 regulation of insulin secretion GO:0050796 9.43 SLC2A2 NEUROD1 KCNJ11 HNF4A GCK ABCC8
25 glucose homeostasis GO:0042593 9.17 WFS1 NEUROD1 IRS1 INSR HNF4A HNF1A

Molecular functions related to Rare Diabetes Mellitus Type 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cation-transporting ATPase activity GO:0019829 9.16 KCNJ11 ABCC8
2 insulin-like growth factor receptor binding GO:0005159 8.96 IRS1 INSR
3 ATP-activated inward rectifier potassium channel activity GO:0015272 8.62 KCNJ11 ABCC8

Sources for Rare Diabetes Mellitus Type 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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