MCID: RRH015
MIFTS: 23

Rare Hemorrhagic Disorder

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Rare Hemorrhagic Disorder

MalaCards integrated aliases for Rare Hemorrhagic Disorder:

Name: Rare Hemorrhagic Disorder 58
Rare Bleeding Disorder 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

UMLS via Orphanet 72 C0005779 C0019087
Orphanet 58 ORPHA248308

Summaries for Rare Hemorrhagic Disorder

MalaCards based summary : Rare Hemorrhagic Disorder, also known as rare bleeding disorder, is related to rare hemorrhagic disorder due to a platelet anomaly and rare hemorrhagic disorder due to an acquired platelet anomaly. The drugs Thrombin and Fibrinolysin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and bone marrow.

Related Diseases for Rare Hemorrhagic Disorder

Diseases in the Hemorrhagic Disease family:

Rare Hemorrhagic Disorder Due to an Acquired Coagulation Factor Defect Hemorrhagic Disease Due to Alpha-1-Antitrypsin Pittsburgh Mutation
Rare Hemorrhagic Disorder Due to a Platelet Anomaly Rare Hemorrhagic Disorder Due to a Coagulation Factors Defect
Rare Hemorrhagic Disorder Rare Hemorrhagic Disorder Due to an Acquired Platelet Anomaly
Rare Hemorrhagic Disorder Due to a Constitutional Thrombocytopenia Rare Hemorrhagic Disorder Due to a Qualitative Platelet Defect
Rare Hemorrhagic Disorder Due to a Constitutional Platelet Anomaly Rare Hemorrhagic Disorder Due to a Constitutional Coagulation Factors Defect

Diseases related to Rare Hemorrhagic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 rare hemorrhagic disorder due to a platelet anomaly 12.4
2 rare hemorrhagic disorder due to an acquired platelet anomaly 12.4
3 rare hemorrhagic disorder due to a constitutional thrombocytopenia 12.4
4 rare hemorrhagic disorder due to a qualitative platelet defect 12.4
5 rare hemorrhagic disorder due to a constitutional platelet anomaly 12.4
6 rare hemorrhagic disorder due to an acquired coagulation factor defect 12.3
7 rare hemorrhagic disorder due to a coagulation factors defect 12.3
8 rare hemorrhagic disorder due to a constitutional coagulation factors defect 12.3
9 factor x deficiency 11.4
10 factor vii deficiency 11.4
11 hemophilia 11.3
12 factor xiii deficiency 11.3
13 factor v deficiency 11.3
14 bleeding disorder, platelet-type, 8 11.0
15 alpha-2-plasmin inhibitor deficiency 10.9
16 plasminogen activator inhibitor-1 deficiency 10.9
17 afibrinogenemia, congenital 10.1
18 von willebrand's disease 10.1
19 thrombasthenia 10.1
20 bernard-soulier syndrome 10.0
21 hemophilia a 10.0
22 factor xi deficiency 10.0
23 thrombophilia due to thrombin defect 9.9
24 thrombosis 9.9
25 prothrombin deficiency 9.9
26 hermansky-pudlak syndrome 9.9
27 acquired hemophilia 9.9
28 autoimmune disease 9.7
29 colorectal cancer 9.7
30 factor viii deficiency 9.7
31 nephrolithiasis, calcium oxalate 9.7
32 pseudo-von willebrand disease 9.7
33 factor v and factor viii, combined deficiency of, 1 9.7
34 hemophilia b 9.7
35 sickle cell anemia 9.7
36 anxiety 9.7
37 thrombotic thrombocytopenic purpura 9.7
38 telangiectasis 9.7
39 thrombocytopenia due to platelet alloimmunization 9.7
40 thrombocytopenia 9.7
41 vascular disease 9.7
42 iron metabolism disease 9.7
43 thrombophilia 9.7
44 membranoproliferative glomerulonephritis 9.7
45 glomerulonephritis 9.7
46 purpura 9.7
47 thrombophlebitis 9.7
48 nephrolithiasis 9.7
49 placenta disease 9.7
50 placental abruption 9.7

Graphical network of the top 20 diseases related to Rare Hemorrhagic Disorder:



Diseases related to Rare Hemorrhagic Disorder

Symptoms & Phenotypes for Rare Hemorrhagic Disorder

Drugs & Therapeutics for Rare Hemorrhagic Disorder

Drugs for Rare Hemorrhagic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational
2
Fibrinolysin Investigational 9004-09-5
3 Fibrinolytic Agents
4 Hemostatics
5 Anti-Infective Agents
6 Antifibrinolytic Agents
7 Antiviral Agents
8 Adjuvants, Immunologic
9 interferons
10 Anti-Bacterial Agents
11 Protective Agents
12 Plasminogen
13 Immunologic Factors
14 Coagulants
15 Antibiotics, Antitubercular
16 Radiation-Protective Agents
17 polysaccharide-K

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Research Study of Factor XIII Concentrate From Human Plasma Fibrogammin P in Patients With Factor XIII Deficiency Completed NCT00640289 Fibrogammin P
2 Haemophilia and Bone Loss PHILEOS Study Recruiting NCT04384341
3 Rare Bleeding Disorders in the Netherlands Recruiting NCT03347591

Search NIH Clinical Center for Rare Hemorrhagic Disorder

Genetic Tests for Rare Hemorrhagic Disorder

Anatomical Context for Rare Hemorrhagic Disorder

MalaCards organs/tissues related to Rare Hemorrhagic Disorder:

40
Bone, Testes, Bone Marrow, Whole Blood, Heart, Kidney, Thyroid

Publications for Rare Hemorrhagic Disorder

Articles related to Rare Hemorrhagic Disorder:

(show top 50) (show all 322)
# Title Authors PMID Year
1
Gynecological and obstetric outcome in the French cohort of women with factor XIII deficiency. 61
32360976 2020
2
The acquired von Willebrand syndrome focused for hematologists. 61
32554559 2020
3
Acquired von Willebrand syndrome and lymphoproliferative disorders: A case report. 61
32477542 2020
4
International recommendations on the diagnosis and treatment of acquired hemophilia A. 61
32381574 2020
5
Characterization of hereditary factor XI deficiency in Taiwanese patients: identification of three novel and two common mutations. 61
32333264 2020
6
Comprehensive N- and O-glycosylation mapping of human coagulation factor V. 61
32310329 2020
7
[Diagnostics on suspicion of a bleeding disorder]. 61
32267642 2020
8
Allergy and inhibitors in hemophilia - a rare complication with potential novel solutions. 61
31669933 2020
9
Long-term outcomes in the treatment of acquired hemophilia A: a 16-year single institution prospective cohort experience. 61
31789659 2020
10
Genetic analysis of a compound heterozygous patient with congenital factor X deficiency and regular replacement therapy with a prothrombin complex concentrate. 61
31667683 2020
11
Acquired factor VIII deficiency in prostate adenocarcinoma presenting as multiple hematomas and hemarthrosis. 61
32110407 2020
12
Congenital factor V deficiency from compound heterozygous mutations with a novel variant c.2426del (p.Pro809Hisfs*2) in the F5 gene: A case report. 61
32000417 2020
13
A Prolonged Treatment Response in Acquired Von Willebrand Syndrome. 61
31546261 2019
14
Congenital Factor XIII Deficiency With the Presence of Inhibitor: A Case Study. 61
31764516 2019
15
Dominant negative Gfi1b mutations cause moderate thrombocytopenia and an impaired stress thrombopoiesis associated with mild erythropoietic abnormalities in mice. 61
31753930 2019
16
Clinical evaluation of bleeds and response to haemostatic treatment in patients with acquired haemophilia: A global expert consensus statement. 61
31517435 2019
17
Lupus anticoagulant-hypoprothrombinemia syndrome and immunoglobulin-A vasculitis: a report of Japanese sibling cases and review of the literature. 61
31392497 2019
18
When age is truly only a number: late diagnosis of von Willebrand disease type 2B in a 61-year-old woman. 61
31464689 2019
19
Development and evaluation of a generic population pharmacokinetic model for standard half-life factor VIII for use in dose individualization. 61
31104228 2019
20
Acquired factor X deficiency in a patient with multiple myeloma: a rare case highlighting the significance of comprehensive evaluation and the need for antimyeloma therapy for bleeding diathesis. 61
31527206 2019
21
Hemophilia C: A Case Report With Updates on Diagnosis and Management of a Rare Bleeding Disorder. 61
32300461 2019
22
Development of an inhibitor in a child with severe hemophilia B: treatment with immunosuppression and an extended desensitization protocol. 61
31259775 2019
23
Bleeding with negative coagulation screening test as initial presentation of chronic myelogenous leukemia managed by fresh frozen plasma: A case report. 61
31464946 2019
24
Acquired hemophilia A in chronic lymphocytic leukemia: A case report. 61
31320278 2019
25
Perioperative Management of a Patient with Severe Factor V Deficiency Presenting with Chronic Subdural Hematoma: A Clinical Report. 61
30999086 2019
26
A Comprehensive Overview of Coagulation Factor V and Congenital Factor V Deficiency. 61
31121608 2019
27
Emicizumab Use in Treatment of Acquired Hemophilia A: A Case Report. 61
31318850 2019
28
Prevention of the anti-factor VIII memory B-cell response by inhibition of Bruton tyrosine kinase in experimental hemophilia A. 61
30545924 2019
29
Factor VII Gene Defects: Review of Functional Studies and Their Clinical Implications 61
30797223 2019
30
Identification of Potential Novel Interacting Partners for Coagulation Factor XIII B (FXIII-B) Subunit, a Protein Associated with a Rare Bleeding Disorder. 61
31159152 2019
31
Design of a prospective observational study on the effectiveness and real-world usage of recombinant factor VIII Fc (rFVIIIFc) compared with conventional products in haemophilia A: the A-SURE study. 61
31152037 2019
32
Disruption of Structural Disulfides of Coagulation FXIII-B Subunit; Functional Implications for a Rare Bleeding Disorder. 61
31013569 2019
33
Compartment syndrome of the forearm with life-threatening bleeding after fasciotomy as the presenting sign of postpartum acquired hemophilia A: a case report. 61
30864964 2019
34
Acquired Haemophilia A. Which is the best therapeutic choice in older adults? Single center study of 4 cases. 61
30932442 2019
35
First Case of Acquired Hemophilia B in a Patient with HIV Infection: Case Report and Literature Review. 61
31106079 2019
36
A Unique Factor XIII Mutation in Southeastern Iran with an Unexpectedly High Prevalence: Khash Factor XIII. 61
30630205 2019
37
Acquired von Willebrand syndrome associated with plasma cell myeloma - a rare histopathological bone marrow image. 61
32146801 2019
38
Management of Dentoalveolar Trauma in a 3-year-old Child with Glanzmann's Thrombasthenia, a Rare Bleeding Disorder: Case Report and Review. 61
32015657 2019
39
Low Concentrations of Recombinant Factor VIIa May Improve the Impaired Thrombin Generation of Glanzmann Thrombasthenia Patients. 61
30597506 2019
40
Inherited Moderate Factor X Deficiency Presenting as Cardiac Tamponade. 61
31662920 2019
41
Acute Myelogenous Leukemia With Trisomy 8 and Concomitant Acquired Factor VII Deficiency. 61
31496295 2019
42
Inhibitor development in patients with congenital factor VII deficiency, a study on 50 Iranian patients. 61
30585836 2019
43
The effect of the chemical chaperone 4-phenylbutyrate on secretion and activity of the p.Q160R missense variant of coagulation factor FVII. 61
31467667 2019
44
[Recurrence of acquired factor V inhibitor after four years of remission]. 61
30726824 2019
45
Acquired factor XIII deficiency: A review. 61
30446212 2018
46
Thromboelastography and thrombin generation assay in inherited afibrinogenemia. 61
30345592 2018
47
Successful hemostatic management of major surgery for cervical spondylotic myelopathy in a patient with severe factor XI deficiency. 61
29713955 2018
48
Anticoagulation in atrial fibrillation with factor X deficiency-A management dilemma. 61
30214763 2018
49
Congenital coagulation factor X deficiency: Genetic analysis of five patients and functional characterization of mutant factor X proteins. 61
30152566 2018
50
Administration of plasma-derived coagulation factor VIII during the perioperative period of mastectomy for breast cancer with acquired von Willebrand syndrome. 61
30225530 2018

Variations for Rare Hemorrhagic Disorder

Expression for Rare Hemorrhagic Disorder

Search GEO for disease gene expression data for Rare Hemorrhagic Disorder.

Pathways for Rare Hemorrhagic Disorder

GO Terms for Rare Hemorrhagic Disorder

Sources for Rare Hemorrhagic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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