MCID: RRS014
MIFTS: 33

Rare Surgical Neurologic Disease

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Rare Surgical Neurologic Disease

MalaCards integrated aliases for Rare Surgical Neurologic Disease:

Name: Rare Surgical Neurologic Disease 59
Neurosurgery 59

Classifications:



External Ids:

Orphanet 59 ORPHA98065

Summaries for Rare Surgical Neurologic Disease

MalaCards based summary : Rare Surgical Neurologic Disease, also known as neurosurgery, is related to diabetes insipidus, neurohypophyseal and megalencephaly-capillary malformation-polymicrogyria syndrome. The drugs Tranexamic Acid and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and spinal cord.

Related Diseases for Rare Surgical Neurologic Disease

Diseases related to Rare Surgical Neurologic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 522)
# Related Disease Score Top Affiliating Genes
1 diabetes insipidus, neurohypophyseal 11.3
2 megalencephaly-capillary malformation-polymicrogyria syndrome 11.3
3 hydrocephalus 10.7
4 congenital hydrocephalus 10.7
5 head injury 10.6
6 arteriovenous malformation 10.5
7 meningioma, radiation-induced 10.5
8 meningioma, familial 10.5
9 spinal meningioma 10.5
10 secretory meningioma 10.5
11 lymphoplasmacyte-rich meningioma 10.5
12 tremor 10.5
13 movement disease 10.5
14 ocular motor apraxia 10.5
15 cerebral aneurysms 10.5
16 traumatic brain injury 10.4
17 meningitis 10.4
18 aneurysm 10.4
19 cerebrovascular disease 10.4
20 obsessive-compulsive disorder 10.4
21 adenoma 10.4
22 trigeminal neuralgia 10.4
23 epilepsy 10.4
24 intracranial hypertension 10.4
25 glioma 10.4
26 glial tumor 10.3
27 neural tube defects 10.3
28 glioblastoma multiforme 10.3
29 glioblastoma 10.3
30 brain injury 10.3
31 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
32 myelomeningocele 10.3
33 craniopharyngioma 10.3
34 essential tremor 10.3
35 pulmonary embolism 10.3
36 cardiac arrest 10.3
37 vascular disease 10.3
38 pituitary tumors 10.3
39 thrombophilia due to thrombin defect 10.2
40 cerebral palsy 10.2
41 chronic pain 10.2
42 spasticity 10.2
43 dystonia 10.2
44 intracranial aneurysm 10.2
45 spinal cord injury 10.2
46 hydrops, lactic acidosis, and sideroblastic anemia 10.2
47 arachnoid cysts 10.2
48 seizure disorder 10.2
49 pik3ca-related overgrowth syndrome 10.2
50 patent foramen ovale 10.2

Graphical network of the top 20 diseases related to Rare Surgical Neurologic Disease:



Diseases related to Rare Surgical Neurologic Disease

Symptoms & Phenotypes for Rare Surgical Neurologic Disease

Drugs & Therapeutics for Rare Surgical Neurologic Disease

Drugs for Rare Surgical Neurologic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 376)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 4 1197-18-8 5526
2
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
3
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
4
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
5
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
6
Morphine Approved, Investigational Phase 4 57-27-2 5288826
7
Meropenem Approved, Investigational Phase 4 119478-56-7, 96036-03-2 64778 441130
8
Parecoxib Approved Phase 4 198470-84-7
9
Histamine Approved, Investigational Phase 4 51-45-6 774
10
Esomeprazole Approved, Investigational Phase 4 119141-88-7, 161796-78-7, 161973-10-0 9568614 4594
11
Famotidine Approved Phase 4 76824-35-6 3325
12
Somatostatin Approved, Investigational Phase 4 38916-34-6, 51110-01-1 53481605
13
lanreotide Approved Phase 4 108736-35-2
14
Esmolol Approved Phase 4 103598-03-4, 81147-92-4 59768
15
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
16
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
17
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
18
Ondansetron Approved Phase 4 99614-02-5 4595
19
Promethazine Approved, Investigational Phase 4 60-87-7 4927
20
Fosaprepitant Approved Phase 4 172673-20-0 219090
21
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
22
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
23
Clevidipine Approved, Investigational Phase 4 167221-71-8
24
Labetalol Approved Phase 4 36894-69-6 3869
25
Hydralazine Approved Phase 4 86-54-4 3637
26
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
27
Thrombin Approved, Investigational Phase 4
28
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
29
Methadone Approved, Illicit Phase 4 76-99-3 4095
30
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
31
tannic acid Approved Phase 4 1401-55-4
32
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
33
Zinc Approved, Investigational Phase 4 7440-66-6 32051
34 Dexketoprofen trometamol Phase 4
35 Hypnotics and Sedatives Phase 4
36 Hormones Phase 4
37 calcium channel blockers Phase 4
38 Pharmaceutical Solutions Phase 4
39 cefuroxime axetil Phase 4
40 Cyclooxygenase 2 Inhibitors Phase 4
41 Autonomic Agents Phase 4
42 Antihypertensive Agents Phase 4
43 Dermatologic Agents Phase 4
44 Gastrointestinal Agents Phase 4
45 Antiemetics Phase 4
46 glucocorticoids Phase 4
47 Antineoplastic Agents, Hormonal Phase 4
48 Hormone Antagonists Phase 4
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
50 Antacids Phase 4

Interventional clinical trials:

(show top 50) (show all 536)
# Name Status NCT ID Phase Drugs
1 Conversion From Total Intravenous Anesthesia Technique to Desflurane Anesthesia for Long Duration Neurosurgery: A Pilot Study for Assessment of Recovery Parameters Unknown status NCT01985854 Phase 4 Propofol;Desflurane
2 Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery: A Randomized Controlled Study Unknown status NCT02552459 Phase 4 Sufentanil;dexmedetomidine 1;dexmedetomidine 2;dexmedetomidine 3
3 An Operator-Blinded Study of the Efficacy of ShuntCheck-Micro-Pumper, a Non-Invasive Diagnostic Procedure, in Detecting Ventricular Shunt Patency or Occlusion and in Predicting Clinical Outcome in Children and Adolescents Presenting to Emergency Departments and Neurosurgery Clinics Unknown status NCT01881711 Phase 4
4 Validation of a New Non Invasive Method of Indirect Measurement of the Intracranial Pressure Variations Unknown status NCT01685450 Phase 4
5 Intranasal Sedation With Dexmedetomidine for Vitroretinal Procedures Unknown status NCT03251222 Phase 4 Dexmedetomidine
6 The Effect of Scalp Block on Surgical Pleth Index(SPI) During a Mayfield Head-holder Insertion in Neurosurgery : a Randomized Control Trial Unknown status NCT02916264 Phase 4
7 Comparison of Efficacy and Safety of the Postoperative Analgesia Methods for Supratentorial Craniotomy by Integrated Pulmonary Index (IPI) Unknown status NCT02929147 Phase 4 Morphine;Dexketoprofen;Placebo
8 Effect of Single Dose of Tramadol on Extubation Response and Quality of Emergence(Cough and Nausea Vomiting) Following Supratentorial Intracranial Surgery Unknown status NCT02964416 Phase 4 Injection Tramadol
9 A Study on the Safety of Tranexamic Acid for the Chronic Subdural Hematoma Population Unknown status NCT02618382 Phase 4 Tranexamic Acid
10 Randomized Controlled Clinical Study of Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury Unknown status NCT02161055 Phase 4 Insulin
11 Does Discontinuation of Aspirin Treatment Following Head Trauma Decrease the Incidence of Chronic Subdural Hematoma? Unknown status NCT01470040 Phase 4 discontinuation of aspirin therapy;continuation of aspirin therapy
12 Prospective, Double-Blind, Randomized, Placebo-Controlled Trial of Single-Dose Cefuroxime Prophylaxis in Herniated Disk Surgery Completed NCT00530400 Phase 4 cefuroxime;placebo
13 Preoperative Valdecoxib: CNS Penetration and Effects on Biochemical Markers of Pain and Sensitization Completed NCT00122096 Phase 4 valdecoxib
14 Use of Dexmedetomidine for Prophylactic Analgesia and Sedation in Patients After Intracranial Surgery (Prophylactic Analgesia and Sedation Trial, PASTrial) Completed NCT01445639 Phase 4 Dexmedetomidine;Normal saline
15 Effect of Remifentanil Infusion Alone During the Closure Period for Early Emergence and Hemodynamic Stability in Patients Undergoing Supratentorial Craniotomy Completed NCT02593942 Phase 4 Remifentanil;Propofol
16 Evaluation of Meropenem Penetration Across Blood-Brain Barrier in Patients With Central Nervous System Infection After Neurosurgery and Optimization of Meropenem Treatment Completed NCT02506686 Phase 4 Meropenem
17 Phase Four Study of Intravenous Parecoxib on Post-craniotomy Pain Completed NCT00455117 Phase 4 Intravenous Parecoxib ('Dynastat' Pfizer)
18 Comparison of Esomeprazole and Famotidine for Stress Ulcer Prophylaxis in Neurosurgical Intensive Care Unit Completed NCT00633035 Phase 4 esomeprazole 40 mg;famotidine 20 mg
19 Fleece Bound Tissue Sealing With TachoSil® to Assist in Closing of the Dura Mater After Elective Craniotomy to Reduce Postoperative Cerebrospinal Fluid (CSF) Leakage. Completed NCT00999999 Phase 4
20 A Comparison of the Perioperative Hemodynamic Effects of Remifentanil and Esmolol: a Double Blind Randomized Controlled Study Completed NCT01628562 Phase 4 Esmolol;Remifentanil
21 Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting Completed NCT01474915 Phase 4 Aprepitant;Ondansetron;Promethazine;Dexamethasone
22 Comparable Effects of Lanreotide Autogel and Octreotide LAR on GH, IGF-I Levels and Patient Satisfaction - A Twelve Month Randomized Cross-Over Study in Patients With Acromegaly Completed NCT00145405 Phase 4 Lanreotide Autogel and Octreotide LAR
23 A Pilot Study to Evaluate Efficacy and Safety of Clevidipine in Neurosurgical Patients Completed NCT00952081 Phase 4 Clevidipine
24 Anesthesia for Deep Brain Stimulation for the Treatment of Parkinsons Disease Completed NCT01789385 Phase 4 Dexmedetomidine
25 EFFICACY OF KETAMINE-PROPOFOL COMBINATION FOR SHORT SURGICAL PROCEDURES Completed NCT01651988 Phase 4 Ketamina-Propofol Combination
26 A Prospective Randomized Controlled Study Evaluating the Safety and Efficacy of EVICEL® Used for Suture-Line Sealing in Dura-Mater Closure During Paediatric Neurosurgical Cranial Procedures Recruiting NCT02309645 Phase 4
27 Anesthetic Sparing Effect of Dexmedetomidine During TIVA With Propofol and Remifentanil for Children Undergoing Dental Procedures Recruiting NCT03422978 Phase 4 Dexmedetomidine;Normal saline
28 Comparison of Propofol and Dexmedetomidine to Treat Hyperactive and Mixed ICU Delirium - the Basel ProDex Randomized Trial Recruiting NCT02807467 Phase 4 Dexmedetomidine;Propofol
29 Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients Recruiting NCT02989597 Phase 4 Methadone Hydrochloride
30 A Comparison of Insulin Sensitivity and Management in Hyperglycemic Patients in the Perioperative Period: ESRD vs. Non-ESRD Recruiting NCT03526536 Phase 4 IV Novolin R human insulin
31 Efficacy of Intravenous Lidocaine in the Operative Management of Thyroid Surgery With Intraoperative Nerve Monitoring Active, not recruiting NCT02479789 Phase 4 Lidocaine;Placebo
32 Does Maintenance of Normoglycemia Change Neurological Outcome in Patients Recovering From Traumatic Brain Injury and Subarachnoid or Intraparenchymal Hemorrhage? Terminated NCT01137773 Phase 4 Insulin;Conventional insulin treatment
33 Stem Cells In Wound Healing With Collagen Matrix as a Carrier Withdrawn NCT02314416 Phase 4
34 Inhaled Nebulised S(+)-Ketamine for Postoperative Analgesia Withdrawn NCT02397356 Phase 4 Ketamine first AB;Placebo first BA
35 Safety and Effectiveness of Capsulotomy in Refractory Obsessive-Compulsive Disorder Unknown status NCT02375152 Phase 2, Phase 3
36 PHASE 3 STUDY OF EFFICACY OF TRANEXAMIC ACID IN BRAIN TUMORS RESECTIONS Unknown status NCT01655927 Phase 3 Tranexamic Acid;Placebo: Saline
37 Adalimumab (Anti TNF Alfa) in the Management of Acute Lumbar Disc Prolapses - a One Year, Randomized, Placebo Controlled, Double Blind, Single Center Trial Unknown status NCT01510548 Phase 3
38 A Prospective Multicenter Double Blind Randomized Controlled Trial to Explore the Tolerability, Safety and Efficacy of the H1-Coil Deep Transcranial Magnetic Stimulation (TMS) in Subjects With Schizophrenia Experiencing Auditory Hallucinations Unknown status NCT00564096 Phase 2, Phase 3
39 Neurosurgery Patient Outcomes in Treating Spinal Disorders Completed NCT01220921 Phase 3
40 Perioperative Magnesium Sulphate as a Cerebral Protector in Neurosurgical Patients Completed NCT01601314 Phase 3 Magnesium Sulfate
41 The Study of NPC-06 - Investigation of Safety, Efficacy and Pharmacokinetics of Fosphenytoin Completed NCT00908453 Phase 3 fosphenytoin
42 Clinical Assessment of the Treatment With Diazoxide in Children Suffering From Obesity and Hyperinsulinemia Secondary to Surgery of Hypothalamic-pituitary Lesions Completed NCT00306683 Phase 3 DIAZOXIDE
43 A Randomized Controlled Trial of Wendan Decoction as a Palliative Treatment for Acute Brain Injury Completed NCT03851809 Phase 2, Phase 3 Wendan decoction combination in acute brain injury
44 Non Invasive Methods for Differential Diagnosis Radionecrosis/Recurrence After Radiosurgery of Brain Metastases. CV-METANEC Completed NCT02636634 Phase 3
45 Dopamine Agonist Cabergoline in Residual Clinically Nonfunctioning Pituitary Adenoma After Transphenoidal Surgery: A Single Center, Open Label and Randomized Clinical Trial Completed NCT03271918 Phase 3 Cabergoline
46 Anesthesiological Strategies in Elective Craniotomy: Randomized, Equivalence, Open Trial Completed NCT00741351 Phase 3 Sevoflurane + Fentanyl;Sevoflurane + Remifentanyl;Propofol + Remifentanyl
47 Comparing the Outcomes Of Incisions Made By Colorado® Microdissection Needle, Electrosurgery Tip And Surgical Blade During Periodontal Surgery Completed NCT03003624 Phase 3
48 A Randomized Trial of Unruptured Brain Arteriovenous Malformations Completed NCT00389181 Phase 3
49 High-dose Simvastatin for Aneurysmal Subarachnoid Haemorrhage: Is it Better? Completed NCT01077206 Phase 2, Phase 3 Simvastatin
50 The Impact of Ventricular Catheter Impregnated With Antimicrobial Agents on Infection in Patients With Ventricular Catheter: A Prospective Randomized Study Completed NCT00286104 Phase 3

Search NIH Clinical Center for Rare Surgical Neurologic Disease

Genetic Tests for Rare Surgical Neurologic Disease

Anatomical Context for Rare Surgical Neurologic Disease

MalaCards organs/tissues related to Rare Surgical Neurologic Disease:

41
Brain, Pituitary, Spinal Cord, Bone, Testes, Cortex, Lung

Publications for Rare Surgical Neurologic Disease

Articles related to Rare Surgical Neurologic Disease:

(show top 50) (show all 18038)
# Title Authors PMID Year
1
Intra-arterial Administration of Verapamil for the Prevention and Treatment of Cerebral Angiospasm. 38
31407082 2020
2
Current Open Surgical Indications for Revascularization in Cerebral Ischemia. 38
31407085 2020
3
Application of neuroendoscopic surgical techniques in the assessment and treatment of cerebral ventricular infection. 38
31397347 2019
4
Dissociating the functions of superior and inferior parts of the left ventral occipito-temporal cortex during visual word and object processing. 38
31176833 2019
5
A Self-Made, Reusable, and Adjustable Device for Making Burr Hole Bone Plugs: Doing More with Less. 38
31181356 2019
6
Central Nervous System Tumors in Uganda: Outcomes of Surgical Treatment and Complications Assessed Through Telephone Survey. 38
31303566 2019
7
The image-guided operating room-Utility and impact on surgeon's performance in the head and neck surgery. 38
31287216 2019
8
A Novel Rat Model for Comprehensive Microvascular Training of End-to-End, End-to-Side, and Side-to-Side Anastomoses. 38
30836413 2019
9
Stereotaxic laser brain surgery with 1940-nm Tm:fiber laser: An in vivo study. 38
30779367 2019
10
Comparison of infection rate with tunneled vs standard external ventricular drainage: A prospective, randomized controlled trial. 38
31319234 2019
11
Blood pressure control and clinical outcomes in acute intracerebral haemorrhage: a preplanned pooled analysis of individual participant data. 38
31397290 2019
12
Fundamentals of Clinical Prediction Modeling for the Neurosurgeon. 38
31418042 2019
13
[Hubris syndrome in neurosurgery]. 38
31364152 2019
14
What is Mission: Neurosurgery, 2018. 38
31428759 2019
15
Clinical Neurosurgery Editors-in-Chief. 38
31428765 2019
16
2018 Neurosurgery Paper of the Year. 38
31428769 2019
17
Commentary: Essential Neurosurgery for Medical Students. 38
31318023 2019
18
Commentary: Essential Neurosurgery for Medical Students. 38
31318025 2019
19
Commentary: Essential Neurosurgery for Medical Students. 38
31318027 2019
20
Commentary: Essential Neurosurgery for Medical Students. 38
31264697 2019
21
Reducing Surgeon's Physical Stress in Minimally Invasive Neurosurgery. 38
31018225 2019
22
Evaluating the Landscape of Clinical Research in Neurosurgery. 38
30809663 2019
23
Commentary: Evaluating the Landscape of Clinical Research in Neurosurgery. 38
31120109 2019
24
A Bibliometric Study of the Most Cited Reports in Central Nervous System Arteriovenous Malformations. 38
31207367 2019
25
Volume-Cost Relationship in Neurosurgery: Analysis of 12,129,029 Admissions from the National Inpatient Sample. 38
31203075 2019
26
Preface to Clinical Neurosurgery Volume 66, Proceedings of the Congress of Neurological Surgeons 2018 Annual Meeting. 38
31428762 2019
27
Preliminary application of mxed reality in neurosurgery: Development and evaluation of a new intraoperative procedure. 38
31221576 2019
28
Functional brain mapping: overview of techniques and their application to neurosurgery. 38
30006663 2019
29
Reimbursement patterns for neurosurgery: Analysis of the NERVES survey results from 2011-2016. 38
31302381 2019
30
Electronic search strategies fail to identify randomized controlled trials (RCTs) in neurosurgery. 38
31377675 2019
31
Female Neurosurgeons in Europe-On a Prevailing Glass Ceiling. 38
31132491 2019
32
Preoperative risk stratification of patient mortality following elective craniotomy; a comparative analysis of prediction algorithms. 38
31279701 2019
33
Trends in High-Impact Neurosurgical Randomized Controlled Trials Published in General Medical Journals: A Systematic Review. 38
31108256 2019
34
Social Media Use for Professional Purposes in the Neurosurgical Community: A Multi-Institutional Study. 38
31132504 2019
35
Psychosocial Stress Reactivity as Predictor of Operative Outcome in Lumbar Disc Surgery. 38
31150852 2019
36
Intracranial Penetrating Trauma Caused by Fishing Sinker. 38
31207368 2019
37
Gender Representation at Neurological Surgery Conferences. 38
31212029 2019
38
Mercury vs. Water: An Analysis of Multi-Institutional Survey Data Assessing Intracranial Pressure Unit of Measure Awareness. 38
31281108 2019
39
Blood-Brain Barrier Dysfunction in Idiopathic Intracranial Hypertension. 38
31393574 2019
40
From decompressive craniectomy to cranioplasty and beyond-a pediatric neurosurgery perspective. 38
31327037 2019
41
Synaptic vesicle protein 2A tumoral expression predicts levetiracetam adverse events. 38
31168673 2019
42
Greening the Operating Room: Results of a Scalable Initiative to Reduce Waste and Recover Supply Costs. 38
30060055 2019
43
Early and midterm results of treatment of giant internal carotid artery paraclinoid aneurysms with trapping and flow diverters. 38
31309305 2019
44
Risk factors of hospital mortality in chronic subdural hematoma: A retrospective analysis of 1117 patients, a single institute experience. 38
31213382 2019
45
A novel method for safe and accurate placement of the rocker pins of head immobilization devices utilizing a digital caliber phantom: technical note. 38
31187236 2019
46
Management of Gorham Stout disease with skull-base defects: Case series of six children and literature review. 38
31195309 2019
47
Combined Hyperactive Dysfunction Syndrome of the Cranial Nerves: Analysis of 37 Cases and Literature Review. 38
31158546 2019
48
The effect of diabetes mellitus on in-hospital hyperglycemia, length of stay and survival in patients with brain tumor receiving dexamethasone: A descriptive and comparative analysis. 38
31376773 2019
49
Andreas Vesalius, the Predecessor of Neurosurgery: How his Progressive Scientific Achievements Affected his Professional Life and Destiny. 38
31201946 2019
50
Value of computerized shunt infusion study in assessment of pediatric hydrocephalus shunt function-a two center cross-sectional study. 38
31372736 2019

Variations for Rare Surgical Neurologic Disease

Expression for Rare Surgical Neurologic Disease

Search GEO for disease gene expression data for Rare Surgical Neurologic Disease.

Pathways for Rare Surgical Neurologic Disease

GO Terms for Rare Surgical Neurologic Disease

Sources for Rare Surgical Neurologic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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