Ras-Associated Autoimmune Leukoproliferative Disorder disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

RALD MCID: RSS025 MIFTS: 47	Ras-Associated Autoimmune Leukoproliferative Disorder (RALD) Categories: Blood diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Ras-Associated Autoimmune Leukoproliferative Disorder

MalaCards integrated aliases for Ras-Associated Autoimmune Leukoproliferative Disorder:

Name: Ras-Associated Autoimmune Leukoproliferative Disorder ⁵⁷ ¹² ⁷⁵ ²⁹ ⁶ ⁷³

Rald ⁵⁷ ¹² ⁵⁹ ⁷⁵

Alps4 ⁵⁷ ¹² ⁷⁵

Ras-Associated Autoimmune Leukoproliferative Disease ¹² ⁵⁹

Autoimmune Lymphoproliferative Syndrome, Type Iv ⁵⁷ ⁷⁵

Autoimmune Lymphoproliferative Syndrome Type Iv ¹² ¹³

Autoimmune Lymphoproliferative Syndrome Type 4 ¹² ¹⁵

Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic ⁵⁷

Ras-Associated Autoimmune Leukoproliferative Disorder ) ⁴⁰

Autoimmune Lymphoproliferative Syndrome, Type Iv; Alps4 ⁵⁷

Autoimmune Lymphoproliferative Syndrome 4 ⁷⁵

Alps Type Iv ¹²

Alps Type 4 ¹²

Characteristics:

Orphanet epidemiological data:

⁵⁹

ras-associated autoimmune leukoproliferative disease
Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood,Infancy;

OMIM:

⁵⁷

Inheritance:
autosomal dominant

Miscellaneous:
onset in childhood
caused by somatic mutations

HPO:

³²

ras-associated autoimmune leukoproliferative disorder:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Other diseases of blood and blood-forming organs

Other disorders of white blood cells

Other specified disorders of white blood cells

Orphanet: ⁵⁹

Rare haematological diseases

Rare immunological diseases

External Ids:

OMIM ⁵⁷ 614470

Disease Ontology ¹² DOID:0110117

ICD10 ³³ D72.8

Orphanet ⁵⁹ ORPHA268114

MedGen ⁴² C2674723

MeSH ⁴⁴ D056735

UMLS ⁷³ C2674723

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Summaries for Ras-Associated Autoimmune Leukoproliferative Disorder

OMIM : ⁵⁷ RAS-associated leukoproliferative disorder is characterized by lymphadenopathy, splenomegaly, and variable autoimmune phenomena, including autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, and neutropenia. Laboratory studies show an expansion of lymphocytes due to defective apoptosis, as well as significant autoantibodies. Some patients have recurrent infections, and there may be an increased risk of hematologic malignancy (summary by Oliveira, 2013 and Niemela et al., 2010). The disorder shows significant overlap with autoimmune lymphoproliferative syndrome (ALPS; 601859) and was originally designated ALPS IV. (614470)

MalaCards based summary : Ras-Associated Autoimmune Leukoproliferative Disorder, also known as rald, is related to autoimmune disease and schimmelpenning-feuerstein-mims syndrome. An important gene associated with Ras-Associated Autoimmune Leukoproliferative Disorder is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Signaling by GPCR and G-AlphaQ Signaling. Affiliated tissues include monocytes, b cells and t cells, and related phenotypes are splenomegaly and recurrent respiratory infections

UniProtKB/Swiss-Prot : ⁷⁵ RAS-associated autoimmune leukoproliferative disorder: A disorder of apoptosis, characterized by chronic accumulation of non- malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies.

Wikipedia : ⁷⁶ RAS-associated autoimmune leukoproliferative disorder (RALD) is a rare genetic disorder of the immune... more...

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Related Diseases for Ras-Associated Autoimmune Leukoproliferative Disorder

Diseases related to Ras-Associated Autoimmune Leukoproliferative Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	autoimmune disease	10.3
2	schimmelpenning-feuerstein-mims syndrome	10.1	KRAS NRAS
3	acneiform dermatitis	10.1	KRAS NRAS
4	core binding factor acute myeloid leukemia	10.1	KRAS NRAS
5	liver angiosarcoma	10.0	KRAS NRAS
6	nevus, epidermal	10.0	KRAS NRAS
7	leukemia, chronic lymphocytic 2	9.9	KRAS NRAS
8	large intestine cancer	9.9	ALDH1A1 KRAS NRAS
9	autoimmune lymphoproliferative syndrome	9.9	KRAS NRAS PRKCD

Graphical network of the top 20 diseases related to Ras-Associated Autoimmune Leukoproliferative Disorder:

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Symptoms & Phenotypes for Ras-Associated Autoimmune Leukoproliferative Disorder

Symptoms via clinical synopsis from OMIM:

⁵⁷

Abdomen Spleen:
splenomegaly

Hematology:
pancytopenia
hemolytic anemia
autoimmune thrombocytopenia

Respiratory:
recurrent respiratory infections (in some patients)

Abdomen Liver:
hepatomegaly

Immunology:
neutropenia
lymphadenopathy
recurrent infections (in some patients)
autoimmune disorders
hypergammaglobulinemia
more

Neoplasia:
increased risk of hematologic malignancy (1 patient)

Clinical features from OMIM:

614470

Human phenotypes related to Ras-Associated Autoimmune Leukoproliferative Disorder:

³² (show all 15)

#	Description	HPO Frequency	HPO Source Accession
1	splenomegaly ³²		HP:0001744
2	recurrent respiratory infections ³²	occasional (7.5%)	HP:0002205
3	hepatomegaly ³²		HP:0002240
4	pancytopenia ³²		HP:0001876
5	hemolytic anemia ³²		HP:0001878
6	neutropenia ³²		HP:0001875
7	lymphoma ³²		HP:0002665
8	increased antibody level in blood ³²		HP:0010702
9	autoimmune thrombocytopenia ³²		HP:0001973
10	lymphocytosis ³²		HP:0100827
11	leukemia ³²		HP:0001909
12	lymphoproliferative disorder ³²		HP:0005523
13	follicular hyperplasia ³²		HP:0002729
14	monocytosis ³²		HP:0012311
15	decreased lymphocyte apoptosis ³²		HP:0002731

MGI Mouse Phenotypes related to Ras-Associated Autoimmune Leukoproliferative Disorder:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10	ALDH1A1 ALDH1A3 CYP26A1 KRAS NRAS PRKCD
2	craniofacial	MP:0005382	9.91	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 KRAS NRAS
3	digestive/alimentary	MP:0005381	9.88	ALDH1A3 CYP26A1 DHRS3 KRAS NRAS PRKCD
4	growth/size/body region	MP:0005378	9.87	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 KRAS NRAS
5	embryo	MP:0005380	9.85	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 KRAS NRAS
6	mortality/aging	MP:0010768	9.8	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 KRAS NRAS
7	normal	MP:0002873	9.55	ALDH1A1 ALDH1A3 CYP26A1 KRAS NRAS
8	skeleton	MP:0005390	9.43	ALDH1A3 CYP26A1 DHRS3 KRAS NRAS PRKCD
9	vision/eye	MP:0005391	9.1	ALDH1A1 ALDH1A3 DHRS3 KRAS NRAS RDH12

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Drugs & Therapeutics for Ras-Associated Autoimmune Leukoproliferative Disorder

Search Clinical Trials , NIH Clinical Center for Ras-Associated Autoimmune Leukoproliferative Disorder

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Genetic Tests for Ras-Associated Autoimmune Leukoproliferative Disorder

Genetic tests related to Ras-Associated Autoimmune Leukoproliferative Disorder:

#	Genetic test	Affiliating Genes
1	Ras-Associated Autoimmune Leukoproliferative Disorder ²⁹	KRAS NRAS

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Anatomical Context for Ras-Associated Autoimmune Leukoproliferative Disorder

MalaCards organs/tissues related to Ras-Associated Autoimmune Leukoproliferative Disorder:

⁴¹

Monocytes, B Cells, T Cells, Liver, Thyroid, Myeloid

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Publications for Ras-Associated Autoimmune Leukoproliferative Disorder

Articles related to Ras-Associated Autoimmune Leukoproliferative Disorder:

#	Title	Authors	Year
1	Cutaneous involvement in an 8-year-old boy with Ras-associated autoimmune leucoproliferative disorder (RALD). ( 29908030 )	Giacaman A...Mart?n-Santiago A	2018
2	T and B cell clonal expansion in Ras-associated lymphoproliferative disease (RALD) as revealed by next-generation sequencing. ( 28500641 )	Levy-Mendelovich S...Somech R	2017
3	JMML and RALD (Ras-associated autoimmune leukoproliferative disorder): common genetic etiology yet clinically distinct entities. ( 25691160 )		2015

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Genes for Ras-Associated Autoimmune Leukoproliferative Disorder

Genes related to Ras-Associated Autoimmune Leukoproliferative Disorder (2 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1732.79	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative somatic mutation ⁵⁹ Causative variation ⁷⁵ Genetic Tests ²⁹ Unconfirmed association ⁵⁷ DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)	17332249 17517660 2407301 (more) 2989702 21079152 19775298
2	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1373.21	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative somatic mutation ⁵⁹ Genetic Tests ²⁹ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)	3627975 17332249 21063026 (more) 25808193 8439212 7773929 20805368 22683711 20949522 22499344 21079152
3	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	16.36	DISEASES inferred ¹⁵
4	DHRS3	Dehydrogenase/Reductase 3	Protein Coding	16.01	DISEASES inferred ¹⁵
5	RDH12	Retinol Dehydrogenase 12	Protein Coding	15.28	DISEASES inferred ¹⁵
6	PRKCD	Protein Kinase C Delta	Protein Coding	15.03	DISEASES inferred ¹⁵
7	ALDH1A3	Aldehyde Dehydrogenase 1 Family Member A3	Protein Coding	14.88	DISEASES inferred ¹⁵
8	CYP26A1	Cytochrome P450 Family 26 Subfamily A Member 1	Protein Coding	14.88	DISEASES inferred ¹⁵

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Variations for Ras-Associated Autoimmune Leukoproliferative Disorder

UniProtKB/Swiss-Prot genetic disease variations for Ras-Associated Autoimmune Leukoproliferative Disorder:

⁷⁵

#	Symbol	AA change	Variation ID	SNP ID
1	NRAS	p.Gly13Asp	VAR_063084	rs121434596

ClinVar genetic disease variations for Ras-Associated Autoimmune Leukoproliferative Disorder:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	KRAS	NM_033360.3(KRAS): c.38G> A (p.Gly13Asp)	single nucleotide variant	Pathogenic	rs112445441	GRCh37	Chromosome 12, 25398281: 25398281
2	KRAS	NM_033360.3(KRAS): c.38G> A (p.Gly13Asp)	single nucleotide variant	Pathogenic	rs112445441	GRCh38	Chromosome 12, 25245347: 25245347
3	KRAS	NM_004985.4(KRAS): c.35G> A (p.Gly12Asp)	single nucleotide variant	Pathogenic	rs121913529	GRCh37	Chromosome 12, 25398284: 25398284
4	KRAS	NM_004985.4(KRAS): c.35G> A (p.Gly12Asp)	single nucleotide variant	Pathogenic	rs121913529	GRCh38	Chromosome 12, 25245350: 25245350
5	NRAS	NM_002524.4(NRAS): c.38G> A (p.Gly13Asp)	single nucleotide variant	Pathogenic	rs121434596	GRCh37	Chromosome 1, 115258744: 115258744
6	NRAS	NM_002524.4(NRAS): c.38G> A (p.Gly13Asp)	single nucleotide variant	Pathogenic	rs121434596	GRCh38	Chromosome 1, 114716123: 114716123
7	KRAS	NM_004985.4(KRAS): c.37G> T (p.Gly13Cys)	single nucleotide variant	Pathogenic	rs121913535	GRCh37	Chromosome 12, 25398282: 25398282
8	KRAS	NM_004985.4(KRAS): c.37G> T (p.Gly13Cys)	single nucleotide variant	Pathogenic	rs121913535	GRCh38	Chromosome 12, 25245348: 25245348

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Expression for Ras-Associated Autoimmune Leukoproliferative Disorder

Search GEO for disease gene expression data for Ras-Associated Autoimmune Leukoproliferative Disorder.

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Pathways for Ras-Associated Autoimmune Leukoproliferative Disorder

Pathways related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

(show top 50) (show all 51)

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁶ Show member pathways GPCR downstream signaling ⁶⁶ Signal Transduction ⁶⁶	13.62	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 KRAS NRAS
2	G-AlphaQ Signaling ⁶⁴ Show member pathways G-AlphaI Signaling ⁶⁴ Thrombin Signaling ⁶⁴	12.48	KRAS NRAS PRKCD
3	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ¹	12.35	KRAS NRAS PRKCD
4	Prolactin Signaling Pathway ¹ ³⁷ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.3	KRAS NRAS PRKCD
5	Development FGFR signaling pathway ²² Show member pathways Development FGF-family signaling ²² Development Flt3 signaling ²² FGF Pathway ⁶⁴	12.26	KRAS NRAS PRKCD
6	Apoptosis Pathway ⁷² Show member pathways Akt Pathway ⁷² NF-kappaB Pathway ⁷²	12.26	KRAS NRAS PRKCD
7	Drug metabolism - cytochrome P450 ³⁷ Show member pathways Aflatoxin B1 metabolism ¹ Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶¹ Arylamine metabolism ¹ Benzo[a]pyrene metabolism ²² Benzodiazepine Pathway, Pharmacokinetics ⁶¹ Celecoxib Pathway, Pharmacokinetics ⁶¹ Chemical carcinogenesis ³⁷ Drug metabolism - other enzymes ³⁷ Fluvoxamine Pathway, Pharmacokinetics ⁶¹ Haloperidol Pathway, Pharmacokinetics ⁶¹ Ifosfamide Pathway, Pharmacokinetics ⁶¹ Metabolism of xenobiotics by cytochrome P450 ³⁷ Naproxen Pathway, Pharmacokinetics ⁶¹ Oxycodone Pathway, Pharmacokinetics ⁶¹ Retinol metabolism ²² Retinol metabolism ³⁷ Voriconazole Pathway, Pharmacokinetics ⁶¹	12.26	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 RDH12
8	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	12.25	KRAS NRAS PRKCD
9	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.24	KRAS NRAS PRKCD
10	VEGF Pathway (Qiagen) ²² Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF Family Ligands and Receptor Interactions ⁶⁴ VEGF Pathway ⁶⁴	12.23	KRAS NRAS PRKCD
11	JAK-STAT signaling pathway (KEGG) ³⁷ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵	12.22	KRAS NRAS PRKCD
12	B cell receptor signaling pathway (KEGG) ³⁷ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.2	KRAS NRAS PRKCD
13	MET promotes cell motility ⁶⁶ Show member pathways Alpha 6 Beta 4 signaling pathway ¹ Laminin interactions ⁶⁶ MET activates PTK2 signaling ⁶⁶ MET activates RAP1 and RAC1 ⁶⁶ MET activates RAS signaling ⁶⁶ MET interacts with TNS proteins ⁶⁶ MET Receptor Activation ⁶⁶ MET receptor recycling ⁶⁶ Signaling by MET ⁶⁶	12.16	KRAS NRAS PRKCD
14	CNTF Signaling ⁶⁴ Show member pathways FLT3 Signaling ⁶⁴ IL-3 Pathway ⁶⁴ Nur77-Induced AICD in Macrophage ⁶⁴ OSM Pathway ⁶⁴	12.14	KRAS NRAS PRKCD
15	Signaling by ERBB2 ⁶⁶ Show member pathways Downregulation of ERBB2 signaling ⁶⁶ Downregulation of ERBB2-ERBB3 signaling ⁶⁶ ERBB2 Activates PTK6 Signaling ⁶⁶ ERBB2 Regulates Cell Motility ⁶⁶ GRB2 events in ERBB2 signaling ⁶⁶ GRB7 events in ERBB2 signaling ⁶⁶ PI3K events in ERBB2 signaling ⁶⁶ PI3K events in ERBB4 signaling ⁶⁶ PLCG1 events in ERBB2 signaling ⁶⁶ SHC1 events in ERBB2 signaling ⁶⁶ SHC1 events in ERBB4 signaling ⁶⁶	12.11	KRAS NRAS PRKCD
16	B Cell Receptor Signaling Pathway (sino) ⁶⁷ Show member pathways T Cell Receptor Signaling Pathway ⁶⁷	12.11	KRAS NRAS PRKCD
17	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²² Show member pathways Activation of the AP-1 family of transcription factors ⁶⁶ Immune response Oncostatin M signaling via MAPK in human cells ²² MAPK Cascade ¹ Oncostatin M Signaling Pathway ¹	12.06	KRAS NRAS PRKCD
18	VEGF Signaling Pathway ⁶¹ ⁶⁷ Show member pathways Nanoparticle-mediated activation of receptor signaling ¹ TGF-beta Signaling ⁶⁷	12	KRAS NRAS PRKCD
19	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	11.99	KRAS NRAS PRKCD
20	Long-term potentiation ³⁷ Show member pathways Common Pathways Underlying Drug Addiction ¹ Dopamine D1-Like Receptor Family Signaling Pathways ⁶⁵	11.95	KRAS NRAS PRKCD
21	NGF Pathway ⁶⁴ Show member pathways TRKA Signaling ⁶⁴	11.91	KRAS NRAS PRKCD
22	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.89	KRAS NRAS PRKCD
23	UVA-Induced MAPK Signaling ⁶⁴ Show member pathways UVB-Induced MAPK Signaling ⁶⁴	11.81	KRAS NRAS PRKCD
24	Autophagy - animal ³⁷	11.78	KRAS NRAS PRKCD
25	Ceramide Pathway ⁶⁴ Show member pathways TNF-Induced Apoptosis Implicating Sphingolipids ⁶⁴	11.72	KRAS NRAS PRKCD
26	Glioblastoma Multiforme ⁶⁴	11.65	KRAS NRAS PRKCD
27	Jak-Stat Signaling Pathway (sino) ⁶⁷	11.6	KRAS NRAS PRKCD
28	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.58	KRAS NRAS PRKCD
29	Central carbon metabolism in cancer ³⁷	11.52	KRAS NRAS
30	Mitophagy - animal ³⁷	11.52	KRAS NRAS
31	Negative regulation of MAPK pathway ⁶⁶ Show member pathways RAF activation ⁶⁶	11.52	KRAS NRAS
32	Long-term depression ³⁷	11.48	KRAS NRAS
33	Agrin Interactions at Neuromuscular Junction ⁶⁴	11.45	KRAS NRAS
34	the visual cycle I (vertebrates) ¹ Show member pathways retinol biosynthesis ¹ The canonical retinoid cycle in rods (twilight vision) ⁶⁶	11.43	DHRS3 RDH12
35	Aryl Hydrocarbon Receptor ¹	11.37	KRAS NRAS
36	VEGF Pathway (Tocris) ⁶¹ Show member pathways VEGF Pathway ⁷²	11.35	KRAS NRAS PRKCD
37	Vemurafenib Pathway, Pharmacodynamics ⁶¹	11.3	KRAS NRAS
38	G-protein signaling_Cross-talk between Ras-family GTPases ²²	11.23	KRAS NRAS PRKCD
39	BDNF-TrkB Signaling ¹	11.19	KRAS NRAS
40	Extracellular vesicle-mediated signaling in recipient cells ¹	11.12	KRAS NRAS
41	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities ¹	11.12	KRAS NRAS
42	Bisphosphonate Pathway, Pharmacodynamics ⁶¹ Show member pathways RalA downstream regulated genes ¹	11.1	KRAS NRAS
43	Signaling by Retinoic Acid ⁶⁶ Show member pathways RA biosynthesis pathway ⁶⁶	11.08	ALDH1A1 ALDH1A3 CYP26A1 DHRS3
44	EGFR Transactivation by Gastrin ⁶⁶ Show member pathways EGFR-dependent Endothelin signaling events ¹ SHC-related events triggered by IGF1R ⁶⁶	11.03	KRAS NRAS
45	MNAR-PELP1 and Estrogen Receptor Interaction ⁶⁴	10.96	KRAS NRAS
46	Transcription_Transcription factor Tubby signaling pathways ²²	10.96	KRAS NRAS PRKCD
47	CD209 (DC-SIGN) signaling ⁶⁶	10.93	KRAS NRAS
48	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling ¹	10.88	KRAS NRAS
49	Vitamin A and Carotenoid Metabolism ¹	10.66	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 RDH12
50	p38MAPK events ⁶⁶	10.64	KRAS NRAS

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GO Terms for Ras-Associated Autoimmune Leukoproliferative Disorder

Biological processes related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidation-reduction process	GO:0055114	9.65	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 RDH12
2	retinoic acid metabolic process	GO:0042573	9.37	ALDH1A3 CYP26A1
3	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.33	KRAS NRAS PRKCD
4	negative regulation of retinoic acid receptor signaling pathway	GO:0048387	9.32	CYP26A1 DHRS3
5	retinoid metabolic process	GO:0001523	9.13	ALDH1A1 DHRS3 RDH12
6	retinol metabolic process	GO:0042572	8.92	ALDH1A1 ALDH1A3 DHRS3 RDH12

Molecular functions related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO:0016620	9.37	ALDH1A1 ALDH1A3
2	retinol dehydrogenase activity	GO:0004745	9.32	DHRS3 RDH12
3	aldehyde dehydrogenase (NAD) activity	GO:0004029	9.26	ALDH1A1 ALDH1A3
4	NADP-retinol dehydrogenase activity	GO:0052650	9.16	DHRS3 RDH12
5	oxidoreductase activity	GO:0016491	9.02	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 RDH12
6	retinal dehydrogenase activity	GO:0001758	8.96	ALDH1A1 ALDH1A3

Sources

Sources for Ras-Associated Autoimmune Leukoproliferative Disorder

¹ BioSystems

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⁵ ClinicalTrials

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⁴¹ MalaCards

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⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

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⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

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⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Ras-Associated Autoimmune Leukoproliferative Disorder (RALD)

Aliases & Classifications for Ras-Associated Autoimmune Leukoproliferative Disorder

MalaCards integrated aliases for Ras-Associated Autoimmune Leukoproliferative Disorder:

Characteristics:

Orphanet epidemiological data:

OMIM:

HPO:

Classifications:

External Ids:

Summaries for Ras-Associated Autoimmune Leukoproliferative Disorder

Related Diseases for Ras-Associated Autoimmune Leukoproliferative Disorder

Diseases related to Ras-Associated Autoimmune Leukoproliferative Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Ras-Associated Autoimmune Leukoproliferative Disorder:

Symptoms & Phenotypes for Ras-Associated Autoimmune Leukoproliferative Disorder

Symptoms via clinical synopsis from OMIM:

Clinical features from OMIM:

Human phenotypes related to Ras-Associated Autoimmune Leukoproliferative Disorder:

MGI Mouse Phenotypes related to Ras-Associated Autoimmune Leukoproliferative Disorder:

Drugs & Therapeutics for Ras-Associated Autoimmune Leukoproliferative Disorder

Genetic Tests for Ras-Associated Autoimmune Leukoproliferative Disorder

Genetic tests related to Ras-Associated Autoimmune Leukoproliferative Disorder:

Anatomical Context for Ras-Associated Autoimmune Leukoproliferative Disorder

MalaCards organs/tissues related to Ras-Associated Autoimmune Leukoproliferative Disorder:

Publications for Ras-Associated Autoimmune Leukoproliferative Disorder

Articles related to Ras-Associated Autoimmune Leukoproliferative Disorder:

Genes for Ras-Associated Autoimmune Leukoproliferative Disorder

Genes related to Ras-Associated Autoimmune Leukoproliferative Disorder (2 elite genes):

Variations for Ras-Associated Autoimmune Leukoproliferative Disorder

UniProtKB/Swiss-Prot genetic disease variations for Ras-Associated Autoimmune Leukoproliferative Disorder:

ClinVar genetic disease variations for Ras-Associated Autoimmune Leukoproliferative Disorder:

Expression for Ras-Associated Autoimmune Leukoproliferative Disorder

Pathways for Ras-Associated Autoimmune Leukoproliferative Disorder

Pathways related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

GO Terms for Ras-Associated Autoimmune Leukoproliferative Disorder

Biological processes related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

Molecular functions related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

Sources for Ras-Associated Autoimmune Leukoproliferative Disorder