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RALD
MCID: RSS025
MIFTS: 52

Ras-Associated Autoimmune Leukoproliferative Disorder (RALD)

Categories: Blood diseases, Cancer diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Ras-Associated Autoimmune Leukoproliferative Disorder

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MalaCards integrated aliases for Ras-Associated Autoimmune Leukoproliferative Disorder:

Name: Ras-Associated Autoimmune Leukoproliferative Disorder 57 12 73 29 6 39 71
Rald 57 12 58 73
Alps4 57 12 73
Ras-Associated Autoimmune Leukoproliferative Disease 12 58
Autoimmune Lymphoproliferative Syndrome, Type Iv 57 73
Autoimmune Lymphoproliferative Syndrome Type Iv 12 13
Autoimmune Lymphoproliferative Syndrome Type 4 12 15
Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic 57
Autoimmune Lymphoproliferative Syndrome, Type Iv; Alps4 57
Autoimmune Lymphoproliferative Syndrome 4 73
Alps Type Iv 12
Alps Type 4 12

Characteristics:

Orphanet epidemiological data:

58
ras-associated autoimmune leukoproliferative disease
Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood,Infancy;

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
autosomal dominant

Miscellaneous:
onset in childhood
caused by somatic mutations


HPO:

31
ras-associated autoimmune leukoproliferative disorder:
Inheritance autosomal dominant inheritance somatic mutation


Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Cancer diseases
Anatomical: Blood diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 32
Orphanet: 58  
Rare haematological diseases
Rare immunological diseases


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Summaries for Ras-Associated Autoimmune Leukoproliferative Disorder

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OMIM® : 57 RAS-associated leukoproliferative disorder is characterized by lymphadenopathy, splenomegaly, and variable autoimmune phenomena, including autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, and neutropenia. Laboratory studies show an expansion of lymphocytes due to defective apoptosis, as well as significant autoantibodies. Some patients have recurrent infections, and there may be an increased risk of hematologic malignancy (summary by Oliveira, 2013 and Niemela et al., 2010). The disorder shows significant overlap with autoimmune lymphoproliferative syndrome (ALPS; 601859) and was originally designated ALPS IV. (614470) (Updated 05-Mar-2021)

MalaCards based summary : Ras-Associated Autoimmune Leukoproliferative Disorder, also known as rald, is related to autoimmune lymphoproliferative syndrome and juvenile myelomonocytic leukemia. An important gene associated with Ras-Associated Autoimmune Leukoproliferative Disorder is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Metabolism and Signaling by GPCR. Affiliated tissues include monocytes, t cells and bone, and related phenotypes are recurrent respiratory infections and splenomegaly

Disease Ontology : 12 An autoimmune lymphoproliferative syndrome that has material basis in somatic mutation in the NRAS gene or the KRAS gene on chromosome 12p12.

UniProtKB/Swiss-Prot : 73 RAS-associated autoimmune leukoproliferative disorder: A disorder of apoptosis, characterized by chronic accumulation of non- malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies.

Wikipedia : 74 RAS-associated autoimmune leukoproliferative disorder (RALD) is a rare genetic disorder of the immune... more...

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Related Diseases for Ras-Associated Autoimmune Leukoproliferative Disorder

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Diseases related to Ras-Associated Autoimmune Leukoproliferative Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 autoimmune lymphoproliferative syndrome 30.5 NRAS KRAS HRAS CASP10
2 juvenile myelomonocytic leukemia 10.4
3 splenomegaly 10.4
4 pyogenic granuloma 10.4 NRAS KRAS
5 hepatic flexure cancer 10.3 KRAS HRAS
6 trachea carcinoma in situ 10.3 KRAS HRAS
7 signet ring basal cell carcinoma 10.3 KRAS HRAS
8 cobblestone retinal degeneration 10.3 KRAS HRAS
9 meningeal melanomatosis 10.3 NRAS HRAS
10 immature teratoma of ovary 10.3 KRAS HRAS
11 descending colon cancer 10.3 KRAS HRAS
12 ampulla of vater neoplasm 10.3 KRAS HRAS
13 malignant anus melanoma 10.3 NRAS HRAS
14 conjunctival nevus 10.3 NRAS HRAS
15 transverse colon cancer 10.3 KRAS HRAS
16 malignant dermis tumor 10.3 NRAS HRAS
17 periampullary adenoma 10.3 KRAS HRAS
18 central nervous system melanocytic neoplasm 10.3 NRAS HRAS
19 malignant skin fibrous histiocytoma 10.3 NRAS HRAS
20 appendiceal neoplasm 10.3 KRAS HRAS
21 gallbladder benign neoplasm 10.3 KRAS HRAS
22 adenosquamous lung carcinoma 10.3 KRAS HRAS
23 vulvar melanoma 10.3 NRAS HRAS
24 appendix adenocarcinoma 10.3 KRAS HRAS
25 mucinous lung adenocarcinoma 10.3 KRAS HRAS
26 wolffian duct adenocarcinoma 10.3 KRAS HRAS
27 myh-associated polyposis 10.3 KRAS HRAS
28 noonan syndrome-like disorder with loose anagen hair 1 10.3 KRAS HRAS
29 ascending colon cancer 10.3 KRAS HRAS
30 biliary tract benign neoplasm 10.3 KRAS HRAS
31 ovarian mucinous neoplasm 10.3 KRAS HRAS
32 malignant exocrine pancreas neoplasm 10.3 KRAS HRAS
33 pancreatic acinar cell adenocarcinoma 10.2 KRAS HRAS
34 paronychia 10.2 KRAS HRAS
35 acneiform dermatitis 10.2 NRAS KRAS HRAS
36 core binding factor acute myeloid leukemia 10.2 NRAS KRAS HRAS
37 oculoectodermal syndrome 10.2 NRAS KRAS HRAS
38 large intestine adenocarcinoma 10.2 NRAS KRAS HRAS
39 schimmelpenning-feuerstein-mims syndrome 10.2 NRAS KRAS HRAS
40 leukemia, acute myeloid 10.2
41 pulmonary hypertension 10.2
42 lymphoproliferative syndrome 10.2
43 chronic myelomonocytic leukemia 10.2
44 hemopericardium 10.2
45 pericardial effusion 10.2
46 thrombocytopenia 10.2
47 pericarditis 10.2
48 interstitial lung disease 10.2
49 lung disease 10.2
50 appendix disease 10.2 KRAS HRAS

Graphical network of the top 20 diseases related to Ras-Associated Autoimmune Leukoproliferative Disorder:



Diseases related to Ras-Associated Autoimmune Leukoproliferative Disorder
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Symptoms & Phenotypes for Ras-Associated Autoimmune Leukoproliferative Disorder

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Human phenotypes related to Ras-Associated Autoimmune Leukoproliferative Disorder:

31 (show all 15)
# Description HPO Frequency HPO Source Accession
1 recurrent respiratory infections 31 occasional (7.5%) HP:0002205
2 splenomegaly 31 HP:0001744
3 hepatomegaly 31 HP:0002240
4 hemolytic anemia 31 HP:0001878
5 leukemia 31 HP:0001909
6 lymphoma 31 HP:0002665
7 neutropenia 31 HP:0001875
8 pancytopenia 31 HP:0001876
9 lymphoproliferative disorder 31 HP:0005523
10 follicular hyperplasia 31 HP:0002729
11 autoimmune thrombocytopenia 31 HP:0001973
12 lymphocytosis 31 HP:0100827
13 monocytosis 31 HP:0012311
14 increased circulating antibody level 31 HP:0010702
15 decreased lymphocyte apoptosis 31 HP:0002731

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Abdomen Spleen:
splenomegaly

Hematology:
hemolytic anemia
pancytopenia
autoimmune thrombocytopenia

Respiratory:
recurrent respiratory infections (in some patients)

Abdomen Liver:
hepatomegaly

Immunology:
neutropenia
lymphadenopathy
monocytosis
recurrent infections (in some patients)
autoimmune disorders
more
Neoplasia:
increased risk of hematologic malignancy (1 patient)

Clinical features from OMIM®:

614470 (Updated 05-Mar-2021)

GenomeRNAi Phenotypes related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

26 (show all 40)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 10.27 KRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 10.27 KRAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.27 KRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-159 10.27 RARS1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 10.27 KRAS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 10.27 KRAS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10.27 RARS1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 10.27 KRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-183 10.27 HRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 10.27 KRAS
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-196 10.27 KRAS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-214 10.27 RARS1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.27 KRAS
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 10.27 KRAS
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 10.27 KRAS
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 10.27 KRAS
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-43 10.27 HRAS
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 10.27 KRAS ZNF423
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 10.27 KRAS
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.27 KRAS
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 10.27 KRAS
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 10.27 HRAS
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 10.27 RARS1
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-93 10.27 KRAS
25 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 10.27 HRAS
26 Decreased viability GR00055-A-1 10.17 HRAS KRAS
27 Decreased viability GR00055-A-2 10.17 HRAS KRAS
28 Decreased viability GR00055-A-3 10.17 KRAS
29 Decreased viability GR00106-A-0 10.17 KRAS
30 Decreased viability GR00221-A-1 10.17 HRAS KRAS NRAS
31 Decreased viability GR00221-A-2 10.17 HRAS KRAS
32 Decreased viability GR00221-A-3 10.17 HRAS NRAS
33 Decreased viability GR00249-S 10.17 ADH7 ALDH1A3 CASP10 RBP4 STRA6
34 Decreased viability GR00301-A 10.17 KRAS
35 Decreased viability GR00381-A-1 10.17 KRAS RBP4 STRA6
36 Decreased viability GR00381-A-2 10.17 RBP4
37 Decreased viability GR00381-A-3 10.17 RBP4
38 Decreased viability GR00386-A-1 10.17 ALDH1A1 BCO1 UCP1 ZNF423
39 Decreased viability GR00402-S-2 10.17 ADH7 ALDH1A3 BCO1 RARS1 UCP1
40 Increased the percentage of infected cells GR00402-S-1 8.62 ALDH1A1 ALDH3B2

MGI Mouse Phenotypes related to Ras-Associated Autoimmune Leukoproliferative Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.31 ADH7 ALDH1A1 ALDH1A2 ALDH1A3 BCO1 CRABP2
2 homeostasis/metabolism MP:0005376 10.21 ADH7 ALDH1A2 ALDH1A3 BCO1 HRAS KRAS
3 embryo MP:0005380 10.16 ALDH1A1 ALDH1A2 ALDH1A3 CYP26A1 KRAS NRAS
4 craniofacial MP:0005382 10.13 ALDH1A1 ALDH1A2 ALDH1A3 HRAS KRAS NRAS
5 mortality/aging MP:0010768 10.13 ADH7 ALDH1A1 ALDH1A2 ALDH1A3 CRABP2 CYP26A1
6 endocrine/exocrine gland MP:0005379 10.09 ALDH1A1 ALDH1A2 ALDH1A3 HRAS KRAS NRAS
7 normal MP:0002873 10 ALDH1A1 ALDH1A2 ALDH1A3 CYP26A1 HRAS KRAS
8 renal/urinary system MP:0005367 9.56 ALDH1A2 ALDH1A3 CYP26A1 HRAS KRAS RBP4
9 pigmentation MP:0001186 9.55 KRAS NRAS RBP1 RBP4 STRA6
10 vision/eye MP:0005391 9.32 ALDH1A1 ALDH1A2 ALDH1A3 KRAS NRAS RBP1
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Drugs & Therapeutics for Ras-Associated Autoimmune Leukoproliferative Disorder

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Search Clinical Trials , NIH Clinical Center for Ras-Associated Autoimmune Leukoproliferative Disorder

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Genetic Tests for Ras-Associated Autoimmune Leukoproliferative Disorder

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Genetic tests related to Ras-Associated Autoimmune Leukoproliferative Disorder:

# Genetic test Affiliating Genes
1 Ras-Associated Autoimmune Leukoproliferative Disorder 29 KRAS NRAS
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Anatomical Context for Ras-Associated Autoimmune Leukoproliferative Disorder

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MalaCards organs/tissues related to Ras-Associated Autoimmune Leukoproliferative Disorder:

40
Monocytes, T Cells, Bone, Liver, Heart, Breast, Myeloid
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Publications for Ras-Associated Autoimmune Leukoproliferative Disorder

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Articles related to Ras-Associated Autoimmune Leukoproliferative Disorder:

(show top 50) (show all 55)
# Title Authors PMID Year
1
Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation. 6 57 61
21063026 2011
2
Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis. 6 57
21079152 2011
3
NRAS mutation causes a human autoimmune lymphoproliferative syndrome. 57 6
17517660 2007
4
Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations. 6
25808193 2015
5
The expanding spectrum of the autoimmune lymphoproliferative syndromes. 57
24240292 2013
6
Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. 6
22683711 2012
7
Keratinocytic epidermal nevi are associated with mosaic RAS mutations. 6
22499344 2012
8
Mosaicism for oncogenic G12D KRAS mutation associated with epidermal nevus, polycystic kidneys and rhabdomyosarcoma. 6
20805368 2010
9
Discordance for Schimmelpenning-Feuerstein-Mims syndrome in monochorionic twins supports the concept of a postzygotic mutation. 6
20949522 2010
10
Germ-line mutation of the NRAS gene may be responsible for the development of juvenile myelomonocytic leukaemia. 6
19775298 2009
11
Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. 6
17332249 2007
12
Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases. 6
7773929 1995
13
Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma. 6
8439212 1993
14
N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis. 6
2407301 1990
15
The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231. 6
3627975 1987
16
Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia. 6
2989702 1985
17
Clinical Spectrum of Ras-Associated Autoimmune Leukoproliferative Disorder (RALD). 61
33011939 2021
18
Idiopathic splenomegaly in childhood and the spectrum of RAS-associated lymphoproliferative disease: a case report. 61
33472608 2021
19
Alcohol Use Behaviors and Reasons to Abstain From or Limit Drinking Among Medically Vulnerable Youth. 61
31985512 2020
20
Risk factors for recurrent autoimmune liver diseases after liver transplantation: A meta-analysis. 61
32443344 2020
21
Relative Average Look Duration and its Association with Neurophysiological Activity in Young Children with Autism Spectrum Disorder. 61
32024855 2020
22
Superficial and Deep Cutaneous Involvement by RAS-Associated Autoimmunne Leukoproliferative Disease (RALD Cutis): A Histologic Mimicker of Histiocytoid Sweet Syndrome. 61
31335417 2019
23
RAS-associated Autoimmune Leukoproliferative disease (RALD) manifested with early-onset SLE-like syndrome: a case series of RALD in Chinese children. 61
31412876 2019
24
A full-width half-maximum method to assess retinal vascular structural changes in patients with ischemic heart disease and microvascular anginga. 61
31358869 2019
25
Cutaneous involvement in an 8-year-old boy with Ras-associated autoimmune leucoproliferative disorder (RALD). 61
29908030 2018
26
Weekly Rituximab Followed by Monthly Rituximab Treatment for Autoimmune Disease Associated With RAS-associated Autoimmune Leukoproliferative Disease. 61
30080751 2018
27
Status of KRAS in iPSCs Impacts upon Self-Renewal and Differentiation Propensity. 61
29983389 2018
28
[Ras-associated autoimmune leukoproliferative disorder: a report of 2 cases and literature review]. 61
29141318 2017
29
T and B cell clonal expansion in Ras-associated lymphoproliferative disease (RALD) as revealed by next-generation sequencing. 61
28500641 2017
30
The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus. 61
28043923 2017
31
Reprogramming of the retinoic acid pathway in decidualizing human endometrial stromal cells. 61
28253328 2017
32
Trajectories and correlates of reasons for abstaining or limiting drinking during adolescence. 61
26320735 2016
33
Somatic mosaicism for a NRAS mutation associates with disparate clinical features in RAS-associated leukoproliferative disease: a report of two cases. 61
25896945 2015
34
JMML and RALD (Ras-associated autoimmune leukoproliferative disorder): common genetic etiology yet clinically distinct entities. 61
25691160 2015
35
Retinaldehyde dehydrogenase 1 deficiency inhibits PPARγ-mediated bone loss and marrow adiposity. 61
25064526 2014
36
Update on retinal vessel structure measurement with spectral-domain optical coherence tomography. 61
24976361 2014
37
Rapid atomic layer deposition of silica nanolaminates: synergistic catalysis of Lewis/Brønsted acid sites and interfacial interactions. 61
24126605 2013
38
Moderate vitamin A supplementation in obese mice regulates tissue factor and cytokine production in a sex-specific manner. 61
23850584 2013
39
Loss-of-function of the protein kinase C δ (PKCδ) causes a B-cell lymphoproliferative syndrome in humans. 61
23430113 2013
40
Deficiency of retinaldehyde dehydrogenase 1 induces BMP2 and increases bone mass in vivo. 61
23951127 2013
41
Autocrine function of aldehyde dehydrogenase 1 as a determinant of diet- and sex-specific differences in visceral adiposity. 61
22933113 2013
42
Monogenic defects in lymphocyte apoptosis. 61
22918222 2012
43
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. 61
22561685 2012
44
Effect of catalyst layer density and growth temperature in rapid atomic layer deposition of silica using tris(tert-pentoxy)silanol. 61
21517074 2011
45
Ralfuranone biosynthesis in Ralstonia solanacearum suggests functional divergence in the quinone synthetase family of enzymes. 61
21439480 2011
46
Laparoscopic live donor nephrectomy: Are ten cases per year enough to reach the quality standards? A report from a single small-volume transplant center. 61
19633883 2010
47
Screening anti-inflammatory components from Chinese traditional medicines using a peritoneal macrophage/cell membrane chromatography-offline-GC/MS method. 61
19664972 2009
48
Reasons for abstaining or limiting drinking: a developmental perspective. 61
19769427 2009
49
[The effects of different occluder selection on cardiac remodeling post transcatheter closure in patients with secundum atrial septal defect]. 61
20128373 2009
50
Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR-RXR complex. 61
18068127 2008
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Variations for Ras-Associated Autoimmune Leukoproliferative Disorder

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ClinVar genetic disease variations for Ras-Associated Autoimmune Leukoproliferative Disorder:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 KRAS NM_004985.5(KRAS):c.101C>G (p.Pro34Arg) SNV Pathogenic 12590 rs104894366 12:25398218-25398218 12:25245284-25245284
2 KRAS NM_004985.5(KRAS):c.38G>A (p.Gly13Asp) SNV Pathogenic 12580 rs112445441 12:25398281-25398281 12:25245347-25245347
3 KRAS NM_004985.5(KRAS):c.37G>T (p.Gly13Cys) SNV Pathogenic 45123 rs121913535 12:25398282-25398282 12:25245348-25245348
4 KRAS NM_004985.5(KRAS):c.458A>T (p.Asp153Val) SNV Pathogenic 12587 rs104894360 12:25362838-25362838 12:25209904-25209904
5 NRAS NM_002524.5(NRAS):c.38G>A (p.Gly13Asp) SNV Pathogenic 13901 rs121434596 1:115258744-115258744 1:114716123-114716123
6 KRAS NM_004985.5(KRAS):c.35G>A (p.Gly12Asp) SNV Pathogenic 12582 rs121913529 12:25398284-25398284 12:25245350-25245350
7 KRAS NM_033360.4(KRAS):c.355G>A (p.Asp119Asn) SNV Likely pathogenic 40460 rs730880471 12:25378643-25378643 12:25225709-25225709
8 KRAS NM_033360.4(KRAS):c.112-5C>T SNV Uncertain significance 626130 rs376520586 12:25380351-25380351 12:25227417-25227417

UniProtKB/Swiss-Prot genetic disease variations for Ras-Associated Autoimmune Leukoproliferative Disorder:

73
# Symbol AA change Variation ID SNP ID
1 NRAS p.Gly13Asp VAR_063084 rs121434596

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Expression for Ras-Associated Autoimmune Leukoproliferative Disorder

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Search GEO for disease gene expression data for Ras-Associated Autoimmune Leukoproliferative Disorder.
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Pathways for Ras-Associated Autoimmune Leukoproliferative Disorder

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Pathways related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Metabolism 65
Show member pathways
 14.05 UCP1 RDH16 RDH10 RBP4 RBP1 RARS1
2
Signaling by GPCR 65
Show member pathways
 13.97 STRA6 RDH16 RDH10 RBP4 RBP1 NRAS
3
Drug metabolism - cytochrome P450 36
Show member pathways
 12.64 RDH16 RDH10 CYP26A1 BCO1 ALDH3B2 ALDH1A3
4
VEGF Signaling 66
Show member pathways
 12.45 NRAS KRAS HRAS CASP10
5
Apoptosis Pathway 70
Show member pathways
 12.38 NRAS KRAS HRAS CASP10
6
Metabolism of fat-soluble vitamins 65
Show member pathways
 12.18 STRA6 RDH16 RDH10 RBP4 RBP1 BCO1
7
Apelin signaling pathway 36
12.04 UCP1 NRAS KRAS HRAS
8
Ceramide Pathway 63
Show member pathways
 11.97 NRAS KRAS HRAS CASP10
9
MAP Kinase Signaling 4
11.92 NRAS KRAS HRAS
10
Glioblastoma Multiforme 63
11.91 NRAS KRAS HRAS
11
Long-term potentiation 36
Show member pathways
 11.9 NRAS KRAS HRAS
12
Signaling by ERBB4 65
Show member pathways
 11.89 NRAS KRAS HRAS
13
AGE-RAGE signaling pathway in diabetic complications 36
11.85 NRAS KRAS HRAS
14
Signaling by EGFR in Cancer 65
Show member pathways
 11.81 NRAS KRAS HRAS
15
Amino Acid metabolism 1
11.8 RARS1 ALDH1A1 ADH7
16
FGFR1 mutant receptor activation 65
Show member pathways
 11.8 NRAS KRAS HRAS
17
Gap junction 36
11.78 NRAS KRAS HRAS
18
VEGF Pathway (Tocris) 60
Show member pathways
 11.7 NRAS KRAS HRAS CASP10
19
Bladder cancer 36 1
11.69 NRAS KRAS HRAS
20
Commom Cytokine Receptor G Chain Siganaling Pathway 66
11.68 NRAS KRAS HRAS
21
Central carbon metabolism in cancer 36
11.67 NRAS KRAS HRAS
22
Mitophagy - animal 36
11.65 NRAS KRAS HRAS
23
Negative regulation of MAPK pathway 65
Show member pathways
 11.63 NRAS KRAS HRAS
24
GnRH secretion 36
11.62 NRAS KRAS HRAS
25
Long-term depression 36
11.58 NRAS KRAS HRAS
26
Agrin Interactions at Neuromuscular Junction 63
11.55 NRAS KRAS HRAS
27
Signaling by Retinoic Acid 65
Show member pathways
 11.52 RDH16 RDH10 CYP26A1 CRABP2 ALDH1A3 ALDH1A2
28
Aryl Hydrocarbon Receptor 1
11.47 NRAS KRAS HRAS
29
the visual cycle I (vertebrates) 1
Show member pathways
 11.46 STRA6 RDH16 RDH10 RBP4 RBP1
30
Vemurafenib Pathway, Pharmacodynamics 60
11.42 NRAS KRAS HRAS
31
Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics 60
11.36 NRAS KRAS HRAS
32
BDNF-TrkB Signaling 1
11.29 NRAS KRAS HRAS
33
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 1
11.22 NRAS KRAS HRAS
34
Extracellular vesicle-mediated signaling in recipient cells 1
11.21 NRAS KRAS HRAS
35
Bisphosphonate Pathway, Pharmacodynamics 60
Show member pathways
 11.19 NRAS KRAS HRAS
36
EGFR Transactivation by Gastrin 65
Show member pathways
 11.13 NRAS KRAS HRAS
37
MNAR-PELP1 and Estrogen Receptor Interaction 63
11.06 NRAS KRAS HRAS
38
CD209 (DC-SIGN) signaling 65
11.03 NRAS KRAS HRAS
39
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling 1
10.97 NRAS KRAS HRAS
40
Vitamin A and Carotenoid Metabolism 1
10.92 RDH10 RBP4 RBP1 CYP26A1 CRABP2 BCO1
41
Diseases associated with visual transduction 65
Show member pathways
 10.91 STRA6 RBP4 RBP1
42
p38MAPK events 65
10.72 NRAS KRAS HRAS
43
retinoate biosynthesis II 1
Show member pathways
 10.55 RDH16 RBP4 RBP1 ALDH1A3 ALDH1A2 ALDH1A1
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GO Terms for Ras-Associated Autoimmune Leukoproliferative Disorder

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Cellular components related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 9.13 RDH16 RDH10 CYP26A1
2 lipid droplet GO:0005811 8.8 RDH10 RBP1 ALDH3B2

Biological processes related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 10.02 RDH16 RDH10 CYP26A1 BCO1 ALDH3B2 ALDH1A3
2 lung development GO:0030324 9.75 STRA6 RBP4 ALDH1A2
3 liver development GO:0001889 9.73 KRAS HRAS ALDH1A2
4 Ras protein signal transduction GO:0007265 9.71 NRAS KRAS HRAS
5 retinoid metabolic process GO:0001523 9.7 STRA6 RDH10 RBP4 RBP1 BCO1 ALDH1A1
6 embryonic forelimb morphogenesis GO:0035115 9.65 RDH10 CRABP2 ALDH1A2
7 retinal metabolic process GO:0042574 9.62 RDH10 BCO1 ALDH1A3 ALDH1A2
8 regulation of long-term neuronal synaptic plasticity GO:0048169 9.61 KRAS HRAS
9 response to vitamin A GO:0033189 9.61 RBP1 CYP26A1 ALDH1A2
10 face development GO:0060324 9.6 ALDH1A3 ALDH1A2
11 embryonic digestive tract development GO:0048566 9.59 STRA6 ALDH1A2
12 ethanol catabolic process GO:0006068 9.58 ALDH3B2 ADH7
13 embryonic camera-type eye development GO:0031076 9.58 RDH10 ALDH1A3 ALDH1A2
14 ear development GO:0043583 9.57 STRA6 RDH10
15 retinoic acid biosynthetic process GO:0002138 9.56 RDH10 RBP1 ALDH1A3 ALDH1A2
16 ethanol oxidation GO:0006069 9.55 ALDH1A1 ADH7
17 response to isolation stress GO:0035900 9.52 KRAS HRAS
18 nose development GO:0043584 9.51 RDH10 ALDH1A3
19 vitamin A metabolic process GO:0006776 9.49 RBP1 ALDH1A2
20 retinol transport GO:0034633 9.46 STRA6 RBP4
21 retinoic acid metabolic process GO:0042573 9.43 RBP1 CYP26A1 CRABP2 ALDH1A3 ALDH1A2 ADH7
22 retinol metabolic process GO:0042572 9.28 RDH16 RDH10 RBP4 RBP1 BCO1 ALDH1A3

Molecular functions related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.81 RDH16 RDH10 CYP26A1 BCO1 ALDH3B2 ALDH1A3
2 GDP binding GO:0019003 9.69 NRAS KRAS HRAS
3 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 9.62 ALDH3B2 ALDH1A3 ALDH1A2 ALDH1A1
4 retinol dehydrogenase activity GO:0004745 9.61 RDH16 RDH10 ADH7
5 retinoid binding GO:0005501 9.58 RBP4 RBP1 CRABP2
6 aldehyde dehydrogenase (NAD) activity GO:0004029 9.56 ALDH3B2 ALDH1A3 ALDH1A2 ALDH1A1
7 retinal dehydrogenase activity GO:0001758 9.54 ALDH1A3 ALDH1A2 ALDH1A1
8 aldehyde dehydrogenase [NAD(P)+] activity GO:0004030 9.49 ALDH3B2 ALDH1A3
9 3-chloroallyl aldehyde dehydrogenase activity GO:0004028 9.48 ALDH3B2 ALDH1A2
10 retinol transmembrane transporter activity GO:0034632 9.46 STRA6 RBP4
11 retinol binding GO:0019841 9.35 STRA6 RBP4 RBP1 CRABP2 ADH7
12 retinal binding GO:0016918 9.02 STRA6 RBP4 RBP1 CRABP2 ALDH1A2
Sources

Sources for Ras-Associated Autoimmune Leukoproliferative Disorder

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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