Ras-Associated Autoimmune Leukoproliferative Disorder disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: RSS025 MIFTS: 43	Ras-Associated Autoimmune Leukoproliferative Disorder Categories: Genetic diseases, Blood diseases, Rare diseases, Immune diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Download Expand all tables

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Aliases & Classifications for Ras-Associated Autoimmune Leukoproliferative Disorder

MalaCards integrated aliases for Ras-Associated Autoimmune Leukoproliferative Disorder:

Name: Ras-Associated Autoimmune Leukoproliferative Disorder ⁵⁷ ¹² ⁷⁵ ²⁹ ⁶ ⁷³

Rald ⁵⁷ ¹² ⁵⁹ ⁷⁵

Alps4 ⁵⁷ ¹² ⁷⁵

Ras-Associated Autoimmune Leukoproliferative Disease ¹² ⁵⁹

Autoimmune Lymphoproliferative Syndrome, Type Iv ⁵⁷ ⁷⁵

Autoimmune Lymphoproliferative Syndrome Type Iv ¹² ¹³

Autoimmune Lymphoproliferative Syndrome Type 4 ¹² ¹⁵

Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic ⁵⁷

Ras-Associated Autoimmune Leukoproliferative Disorder ) ⁴⁰

Autoimmune Lymphoproliferative Syndrome, Type Iv; Alps4 ⁵⁷

Autoimmune Lymphoproliferative Syndrome 4 ⁷⁵

Alps Type Iv ¹²

Alps Type 4 ¹²

Characteristics:

Orphanet epidemiological data:

⁵⁹

ras-associated autoimmune leukoproliferative disease
Prevalence: <1/1000000 (Worldwide); Age of onset: Childhood,Infancy;

OMIM:

⁵⁷

Inheritance:
autosomal dominant

Miscellaneous:
onset in childhood
caused by somatic mutations

HPO:

³²

ras-associated autoimmune leukoproliferative disorder:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Other diseases of blood and blood-forming organs

Other disorders of white blood cells

Other specified disorders of white blood cells

Orphanet: ⁵⁹

Rare haematological diseases

Rare immunological diseases

External Ids:

OMIM ⁵⁷ 614470

Disease Ontology ¹² DOID:0110117

ICD10 ³³ D72.8

Orphanet ⁵⁹ ORPHA268114

MedGen ⁴² C2674723

MeSH ⁴⁴ D056735

UMLS ⁷³ C2674723

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Summaries for Ras-Associated Autoimmune Leukoproliferative Disorder

OMIM : ⁵⁷ RAS-associated leukoproliferative disorder is characterized by lymphadenopathy, splenomegaly, and variable autoimmune phenomena, including autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, and neutropenia. Laboratory studies show an expansion of lymphocytes due to defective apoptosis, as well as significant autoantibodies. Some patients have recurrent infections, and there may be an increased risk of hematologic malignancy (summary by Oliveira, 2013 and Niemela et al., 2010). The disorder shows significant overlap with autoimmune lymphoproliferative syndrome (ALPS; 601859) and was originally designated ALPS IV. (614470)

MalaCards based summary : Ras-Associated Autoimmune Leukoproliferative Disorder, also known as rald, is related to schimmelpenning-feuerstein-mims syndrome and nevus, epidermal. An important gene associated with Ras-Associated Autoimmune Leukoproliferative Disorder is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Signaling by GPCR and 4-1BB Pathway. Affiliated tissues include monocytes, t cells and b cells, and related phenotypes are splenomegaly and recurrent respiratory infections

UniProtKB/Swiss-Prot : ⁷⁵ RAS-associated autoimmune leukoproliferative disorder: A disorder of apoptosis, characterized by chronic accumulation of non- malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies.

Wikipedia : ⁷⁶ RAS-associated autoimmune leukoproliferative disorder (RALD) is a rare genetic disorder of the immune... more...

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Related Diseases for Ras-Associated Autoimmune Leukoproliferative Disorder

Diseases related to Ras-Associated Autoimmune Leukoproliferative Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	schimmelpenning-feuerstein-mims syndrome	10.3	KRAS NRAS
2	nevus, epidermal	10.2	KRAS NRAS
3	acneiform dermatitis	10.2	KRAS NRAS
4	core binding factor acute myeloid leukemia	10.1	KRAS NRAS
5	liver angiosarcoma	10.0	KRAS NRAS
6	small intestinal adenocarcinoma	9.7	ALDH1A1 KRAS
7	autoimmune lymphoproliferative syndrome	9.6	KRAS NRAS PRKCD

Graphical network of the top 20 diseases related to Ras-Associated Autoimmune Leukoproliferative Disorder:

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Symptoms & Phenotypes for Ras-Associated Autoimmune Leukoproliferative Disorder

Symptoms via clinical synopsis from OMIM:

⁵⁷

AbdomenSpleen:
splenomegaly

Hematology:
pancytopenia
hemolytic anemia
autoimmune thrombocytopenia

Respiratory:
recurrent respiratory infections (in some patients)

Abdomen Liver:
hepatomegaly

Immunology:
neutropenia
lymphadenopathy
recurrent infections (in some patients)
autoimmune disorders
hypergammaglobulinemia
more

Neoplasia:
increased risk of hematologic malignancy (1 patient)

Clinical features from OMIM:

614470

Human phenotypes related to Ras-Associated Autoimmune Leukoproliferative Disorder:

³² (show all 14)

#	Description	HPO Frequency	HPO Source Accession
1	splenomegaly ³²		HP:0001744
2	recurrent respiratory infections ³²	occasional (7.5%)	HP:0002205
3	hepatomegaly ³²		HP:0002240
4	pancytopenia ³²		HP:0001876
5	hemolytic anemia ³²		HP:0001878
6	neutropenia ³²		HP:0001875
7	lymphoma ³²		HP:0002665
8	increased antibody level in blood ³²		HP:0010702
9	autoimmune thrombocytopenia ³²		HP:0001973
10	leukemia ³²		HP:0001909
11	lymphoproliferative disorder ³²		HP:0005523
12	follicular hyperplasia ³²		HP:0002729
13	monocytosis ³²		HP:0012311
14	decreased lymphocyte apoptosis ³²		HP:0002731

MGI Mouse Phenotypes related to Ras-Associated Autoimmune Leukoproliferative Disorder:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10	ALDH1A1 ALDH1A3 CYP26A1 KRAS NRAS PRKCD
2	craniofacial	MP:0005382	9.91	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 KRAS NRAS
3	growth/size/body region	MP:0005378	9.87	PRKCD ALDH1A1 ALDH1A3 CYP26A1 DHRS3 KRAS
4	embryo	MP:0005380	9.85	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 KRAS NRAS
5	digestive/alimentary	MP:0005381	9.8	ALDH1A3 CYP26A1 DHRS3 KRAS NRAS
6	mortality/aging	MP:0010768	9.8	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 KRAS NRAS
7	normal	MP:0002873	9.55	ALDH1A1 ALDH1A3 CYP26A1 KRAS NRAS
8	skeleton	MP:0005390	9.43	ALDH1A3 CYP26A1 DHRS3 KRAS NRAS PRKCD
9	vision/eye	MP:0005391	9.1	DHRS3 KRAS NRAS RDH12 ALDH1A1 ALDH1A3

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Drugs & Therapeutics for Ras-Associated Autoimmune Leukoproliferative Disorder

Search Clinical Trials , NIH Clinical Center for Ras-Associated Autoimmune Leukoproliferative Disorder

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Genetic Tests for Ras-Associated Autoimmune Leukoproliferative Disorder

Genetic tests related to Ras-Associated Autoimmune Leukoproliferative Disorder:

#	Genetic test	Affiliating Genes
1	Ras-Associated Autoimmune Leukoproliferative Disorder ²⁹	KRAS NRAS

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Anatomical Context for Ras-Associated Autoimmune Leukoproliferative Disorder

MalaCards organs/tissues related to Ras-Associated Autoimmune Leukoproliferative Disorder:

⁴¹

Monocytes, T Cells, B Cells

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Publications for Ras-Associated Autoimmune Leukoproliferative Disorder

Articles related to Ras-Associated Autoimmune Leukoproliferative Disorder:

#	Title	Authors	Year
1	JMML and RALD (Ras-associated autoimmune leukoproliferative disorder): common genetic etiology yet clinically distinct entities. ( 25691160 )	Calvo K.R....Rao V.K.	2015

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Genes for Ras-Associated Autoimmune Leukoproliferative Disorder

Genes related to Ras-Associated Autoimmune Leukoproliferative Disorder (2 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1733.1	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative somatic mutation ⁵⁹ Causative variation ⁷⁵ Genetic Tests ²⁹ Unconfirmed association ⁵⁷ DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Variants (show sections)	17332249 17517660 2407301 (more) 2989702 21079152 19775298
2	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1372.79	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative somatic mutation ⁵⁹ Genetic Tests ²⁹ DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)	3627975 17332249 21063026 (more) 25808193 8439212 7773929 20805368 22683711 20949522 22499344 21079152
3	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	16.58	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	DHRS3	Dehydrogenase/Reductase 3	Protein Coding	16.12	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	RDH12	Retinol Dehydrogenase 12	Protein Coding	15.39	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	PRKCD	Protein Kinase C Delta	Protein Coding	15.2	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	ALDH1A3	Aldehyde Dehydrogenase 1 Family Member A3	Protein Coding	15.06	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	CYP26A1	Cytochrome P450 Family 26 Subfamily A Member 1	Protein Coding	15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Ras-Associated Autoimmune Leukoproliferative Disorder

UniProtKB/Swiss-Prot genetic disease variations for Ras-Associated Autoimmune Leukoproliferative Disorder:

⁷⁵

#	Symbol	AA change	Variation ID	SNP ID
1	NRAS	p.Gly13Asp	VAR_063084	rs121434596

ClinVar genetic disease variations for Ras-Associated Autoimmune Leukoproliferative Disorder:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	KRAS	NM_033360.3(KRAS): c.38G> A (p.Gly13Asp)	single nucleotide variant	Pathogenic	rs112445441	GRCh37	Chromosome 12, 25398281: 25398281
2	KRAS	NM_033360.3(KRAS): c.38G> A (p.Gly13Asp)	single nucleotide variant	Pathogenic	rs112445441	GRCh38	Chromosome 12, 25245347: 25245347
3	KRAS	NM_004985.4(KRAS): c.35G> A (p.Gly12Asp)	single nucleotide variant	Pathogenic	rs121913529	GRCh37	Chromosome 12, 25398284: 25398284
4	KRAS	NM_004985.4(KRAS): c.35G> A (p.Gly12Asp)	single nucleotide variant	Pathogenic	rs121913529	GRCh38	Chromosome 12, 25245350: 25245350
5	NRAS	NM_002524.4(NRAS): c.38G> A (p.Gly13Asp)	single nucleotide variant	Pathogenic	rs121434596	GRCh37	Chromosome 1, 115258744: 115258744
6	NRAS	NM_002524.4(NRAS): c.38G> A (p.Gly13Asp)	single nucleotide variant	Pathogenic	rs121434596	GRCh38	Chromosome 1, 114716123: 114716123
7	KRAS	NM_033360.3(KRAS): c.37G> T (p.Gly13Cys)	single nucleotide variant	Pathogenic	rs121913535	GRCh37	Chromosome 12, 25398282: 25398282
8	KRAS	NM_033360.3(KRAS): c.37G> T (p.Gly13Cys)	single nucleotide variant	Pathogenic	rs121913535	GRCh38	Chromosome 12, 25245348: 25245348

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Expression for Ras-Associated Autoimmune Leukoproliferative Disorder

Search GEO for disease gene expression data for Ras-Associated Autoimmune Leukoproliferative Disorder.

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Pathways for Ras-Associated Autoimmune Leukoproliferative Disorder

Pathways related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

(show all 45)

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁶ Show member pathways GPCR downstream signaling ⁶⁶ Signal Transduction ⁶⁶	13.62	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 KRAS NRAS
2	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.46	KRAS NRAS PRKCD
3	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ¹	12.34	KRAS NRAS PRKCD
4	Prolactin Signaling Pathway ¹ ³⁷ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.29	KRAS NRAS PRKCD
5	Development FGFR signaling pathway ²² Show member pathways Development FGF-family signaling ²² Development Flt3 signaling ²² FGF Pathway ⁶⁴	12.26	KRAS NRAS PRKCD
6	Apoptosis Pathway ⁷² Show member pathways Akt Pathway ⁷² NF-kappaB Pathway ⁷²	12.26	KRAS NRAS PRKCD
7	CNTF Signaling ⁶⁴ Show member pathways BDNF Pathway ⁶⁴ FLT3 Signaling ⁶⁴ IL-3 Pathway ⁶⁴ Nur77-Induced AICD in Macrophage ⁶⁴ OSM Pathway ⁶⁴	12.25	KRAS NRAS PRKCD
8	Drug metabolism - cytochrome P450 ³⁷ Show member pathways Aflatoxin B1 metabolism ¹ Arylamine metabolism ¹ Benzo[a]pyrene metabolism ²² Benzodiazepine Pathway, Pharmacokinetics ⁶¹ Celecoxib Pathway, Pharmacokinetics ⁶¹ Chemical carcinogenesis ³⁷ Drug metabolism - other enzymes ³⁷ Fluvoxamine Pathway, Pharmacokinetics ⁶¹ Haloperidol Pathway, Pharmacokinetics ⁶¹ Ifosfamide Pathway, Pharmacokinetics ⁶¹ Metabolism of xenobiotics by cytochrome P450 ³⁷ Naproxen Pathway, Pharmacokinetics ⁶¹ Oxycodone Pathway, Pharmacokinetics ⁶¹ Retinol metabolism ³⁷ Retinol metabolism ²² Voriconazole Pathway, Pharmacokinetics ⁶¹	12.25	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 RDH12
9	CLEC7A (Dectin-1) signaling ⁶⁶ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁶ C-type lectin receptors (CLRs) ⁶⁶	12.24	KRAS NRAS PRKCD
10	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.24	KRAS NRAS PRKCD
11	VEGF Pathway (Qiagen) ⁶⁴ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF Family Ligands and Receptor Interactions ⁶⁴	12.22	KRAS NRAS PRKCD
12	B cell receptor signaling pathway (KEGG) ³⁷ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	12.19	KRAS NRAS PRKCD
13	MET promotes cell motility ⁶⁶ Show member pathways Alpha 6 Beta 4 signaling pathway ¹ Laminin interactions ⁶⁶ MET activates PTK2 signaling ⁶⁶ MET activates RAP1 and RAC1 ⁶⁶ MET activates RAS signaling ⁶⁶ MET interacts with TNS proteins ⁶⁶ MET Receptor Activation ⁶⁶ MET receptor recycling ⁶⁶ Signaling by MET ⁶⁶	12.15	KRAS NRAS PRKCD
14	B Cell Receptor Signaling Pathway (sino) ⁶⁷ Show member pathways B Cell Receptor Signaling Pathway ⁶⁷	12.12	KRAS NRAS PRKCD
15	Signaling by ERBB2 ⁶⁶ Show member pathways Downregulation of ERBB2 signaling ⁶⁶ Downregulation of ERBB2-ERBB3 signaling ⁶⁶ ERBB2 Activates PTK6 Signaling ⁶⁶ ERBB2 Regulates Cell Motility ⁶⁶ GRB2 events in ERBB2 signaling ⁶⁶ GRB7 events in ERBB2 signaling ⁶⁶ PI3K events in ERBB2 signaling ⁶⁶ PI3K events in ERBB4 signaling ⁶⁶ PLCG1 events in ERBB2 signaling ⁶⁶ SHC1 events in ERBB2 signaling ⁶⁶ SHC1 events in ERBB4 signaling ⁶⁶	12.11	KRAS NRAS PRKCD
16	VEGF Signaling Pathway ⁶⁷ ⁶¹ Show member pathways Nanoparticle-mediated activation of receptor signaling ¹ TGF-beta Signaling ⁶⁷	12.01	KRAS NRAS PRKCD
17	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	11.99	KRAS NRAS PRKCD
18	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²² Show member pathways Activation of the AP-1 family of transcription factors ⁶⁶ Immune response Oncostatin M signaling via MAPK in human cells ²² MAPK Cascade ¹ Oncostatin M Signaling Pathway ¹	11.97	KRAS NRAS PRKCD
19	Long-term potentiation ³⁷ Show member pathways Common Pathways Underlying Drug Addiction ¹ Dopamine D1-Like Receptor Family Signaling Pathways ⁶⁵	11.95	KRAS NRAS PRKCD
20	NGF Pathway ⁶⁴ Show member pathways TRKA Signaling ⁶⁴	11.91	KRAS NRAS PRKCD
21	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.88	KRAS NRAS PRKCD
22	Autophagy - animal ³⁷	11.76	KRAS NRAS PRKCD
23	Ceramide Pathway ⁶⁴ Show member pathways TNF-Induced Apoptosis Implicating Sphingolipids ⁶⁴	11.72	KRAS NRAS PRKCD
24	Glioblastoma Multiforme ⁶⁴	11.65	KRAS NRAS PRKCD
25	Jak-Stat Signaling Pathway ⁶⁷	11.64	KRAS NRAS PRKCD
26	AGE-RAGE signaling pathway in diabetic complications ³⁷	11.58	KRAS NRAS PRKCD
27	Long-term depression ³⁷	11.47	KRAS NRAS
28	Agrin Interactions at Neuromuscular Junction ⁶⁴	11.44	KRAS NRAS
29	the visual cycle I (vertebrates) ¹ Show member pathways retinol biosynthesis ¹ The canonical retinoid cycle in rods (twilight vision) ⁶⁶	11.43	DHRS3 RDH12
30	Aryl Hydrocarbon Receptor ¹	11.36	KRAS NRAS
31	VEGF Pathway (Tocris) ⁷² Show member pathways Sorafenib Pharmacodynamics ⁶¹	11.35	KRAS NRAS PRKCD
32	Vemurafenib Pathway, Pharmacodynamics ⁶¹	11.29	KRAS NRAS
33	BDNF-TrkB Signaling ¹	11.18	KRAS NRAS
34	Extracellular vesicle-mediated signaling in recipient cells ¹	11.11	KRAS NRAS
35	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities ¹	11.11	KRAS NRAS
36	Bisphosphonate Pathway, Pharmacodynamics ⁶¹ Show member pathways RalA downstream regulated genes ¹	11.09	KRAS NRAS
37	Signaling by Retinoic Acid ⁶⁶ Show member pathways RA biosynthesis pathway ⁶⁶	11.08	ALDH1A1 ALDH1A3 CYP26A1 DHRS3
38	EGFR Transactivation by Gastrin ⁶⁶ Show member pathways EGFR-dependent Endothelin signaling events ¹ SHC-related events triggered by IGF1R ⁶⁶	11.02	KRAS NRAS
39	MNAR-PELP1 and Estrogen Receptor Interaction ⁶⁴	10.96	KRAS NRAS
40	Transcription_Transcription factor Tubby signaling pathways ²²	10.96	KRAS NRAS PRKCD
41	CD209 (DC-SIGN) signaling ⁶⁶	10.93	KRAS NRAS
42	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling ¹	10.87	KRAS NRAS
43	Vitamin A and Carotenoid Metabolism ¹	10.66	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 RDH12
44	p38MAPK events ⁶⁶	10.62	KRAS NRAS
45	retinoate biosynthesis II ¹ Show member pathways retinoate biosynthesis I ¹ Retinoid metabolism disease events ⁶⁶	10.61	ALDH1A1 ALDH1A3

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GO Terms for Ras-Associated Autoimmune Leukoproliferative Disorder

Biological processes related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidation-reduction process	GO:0055114	9.55	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 RDH12
2	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.5	KRAS NRAS PRKCD
3	epidermal growth factor receptor signaling pathway	GO:0007173	9.43	KRAS NRAS
4	ERBB2 signaling pathway	GO:0038128	9.4	KRAS NRAS
5	retinoic acid metabolic process	GO:0042573	9.37	ALDH1A3 CYP26A1
6	negative regulation of retinoic acid receptor signaling pathway	GO:0048387	9.26	CYP26A1 DHRS3
7	retinoid metabolic process	GO:0001523	9.13	ALDH1A1 DHRS3 RDH12
8	retinol metabolic process	GO:0042572	8.92	ALDH1A1 ALDH1A3 DHRS3 RDH12

Molecular functions related to Ras-Associated Autoimmune Leukoproliferative Disorder according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	GO:0016620	9.4	ALDH1A1 ALDH1A3
2	retinol dehydrogenase activity	GO:0004745	9.37	DHRS3 RDH12
3	aldehyde dehydrogenase (NAD) activity	GO:0004029	9.32	ALDH1A1 ALDH1A3
4	NADP-retinol dehydrogenase activity	GO:0052650	9.26	DHRS3 RDH12
5	3-chloroallyl aldehyde dehydrogenase activity	GO:0004028	9.16	ALDH1A1 ALDH1A3
6	oxidoreductase activity	GO:0016491	9.02	ALDH1A1 ALDH1A3 CYP26A1 DHRS3 RDH12
7	retinal dehydrogenase activity	GO:0001758	8.96	ALDH1A1 ALDH1A3

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Sources for Ras-Associated Autoimmune Leukoproliferative Disorder

¹ BioSystems

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⁵⁵ Novoseek

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⁵⁷ OMIM

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⁵⁹ Orphanet

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⁶¹ PharmGKB

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⁶⁸ SNOMED-CT

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⁷¹ TGDB

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⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia