Rasopathy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: RSP023 MIFTS: 54	Rasopathy Categories: Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Rasopathy

MalaCards integrated aliases for Rasopathy:

Name: Rasopathy ¹¹ ⁵⁸ ²⁸ ⁵ ¹⁴ ¹⁶ ⁷⁵

Ras/mitogen-Activated Protein Kinase Syndrome ¹¹

Classifications:

MalaCards categories:
Global: Rare diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0080690

Orphanet ⁵⁸ ORPHA536391

EFO ¹⁶ EFO_1001502

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Summaries for Rasopathy

Disease Ontology: ¹¹ A syndrome that has material basis in mutations in genes that alter the Ras subfamily and mitogen-activated protein kinases that control signal transduction.

MalaCards based summary: Rasopathy, also known as ras/mitogen-activated protein kinase syndrome, is related to costello syndrome and noonan syndrome 1. An important gene associated with Rasopathy is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways are ERK Signaling and Disease. Affiliated tissues include myeloid, heart and spinal cord, and related phenotypes are Decreased viability and Increased shRNA abundance (Z-score > 2)

Wikipedia: ⁷⁵ The RASopathies are developmental syndromes caused by germline mutations (or in rare cases by somatic... more...

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Related Diseases for Rasopathy

Diseases related to Rasopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 268)

#	Related Disease	Score	Top Affiliating Genes
1	costello syndrome	33.1	SPRED1 SOS2 SOS1 SHOC2 RAF1 PTPN11
2	noonan syndrome 1	33.1	U2AF1 SPRED1 SOS2 SOS1 SHOC2 RIT1
3	noonan syndrome with multiple lentigines	33.1	SPRED1 SOS2 SOS1 SHOC2 RIT1 RAF1
4	cardiofaciocutaneous syndrome 1	33.0	SPRED1 SOS2 SOS1 SHOC2 RIT1 RAF1
5	neurofibromatosis-noonan syndrome	32.8	SPRED1 SOS2 SOS1 SHOC2 PTPN11 NF1
6	noonan syndrome-like disorder with loose anagen hair	32.6	SPRED1 SOS2 SOS1 SHOC2 PTPN11 MAP2K1
7	legius syndrome	32.5	SPRED1 NF1 HRAS
8	neurofibromatosis	31.7	SPRED1 SOS1 PTPN11 NRAS NF1 LZTR1
9	hypertrophic cardiomyopathy	31.7	SOS2 SOS1 SHOC2 RIT1 RAF1 PTPN11
10	neurofibromatosis, type i	31.7	SPRED1 SOS1 RAF1 PTPN11 NRAS NF1
11	pseudo-turner syndrome	31.6	SOS2 SOS1 SHOC2 RIT1 RAF1 PTPN11
12	rhabdomyosarcoma	31.4	SOS1 PTPN11 NRAS NF1 MAP2K2 MAP2K1
13	juvenile myelomonocytic leukemia	31.3	U2AF1 SPRED1 SOS2 SOS1 SHOC2 RIT1
14	lentigines	31.1	RAF1 PTPN11 BRAF
15	schimmelpenning-feuerstein-mims syndrome	31.1	SOS1 NRAS NF1 LRRC56 KRAS HRAS
16	pulmonic stenosis	31.1	SOS1 RAF1 PTPN11 NF1 MAP2K2 MAP2K1
17	noonan syndrome and noonan-related syndrome	31.0	SPRED1 SOS1 SHOC2 RIT1 RAF1 PTPN11
18	leukemia, acute myeloid	31.0	U2AF1 PTPN11 NRAS NF1 MAP2K1 LRRC56
19	melanocytic nevus syndrome, congenital	31.0	NRAS LRRC56 HRAS
20	noonan syndrome 3	31.0	SOS1 RAF1 PTPN11 LRRC56 KRAS HRAS
21	nevus, epidermal	30.9	NRAS NF1 LRRC56 KRAS HRAS
22	noonan syndrome-like disorder with loose anagen hair 1	30.9	SHOC2 PTPN11 KRAS HRAS
23	wilms tumor 1	30.9	U2AF1 NF1 KRAS HRAS BRAF
24	melanoma in congenital melanocytic nevus	30.9	RAF1 NRAS HRAS BRAF
25	melanoma	30.9	SOS1 RAF1 NRAS NF1 MAP2K2 MAP2K1
26	breast cancer	30.9	SOS1 RAF1 PTPN11 NRAS NF1 MIR499A
27	ras-associated autoimmune leukoproliferative disorder	30.8	NRAS KRAS HRAS
28	leukemia	30.8	U2AF1 RAF1 PTPN11 NRAS NF1 BRAF
29	myelodysplastic/myeloproliferative neoplasm	30.7	U2AF1 SOS1 PTPN11 NRAS NF1 HRAS
30	chronic myelomonocytic leukemia	30.7	U2AF1 PTPN11 NRAS NF1 KRAS HRAS
31	arteriovenous malformation	30.7	NF1 MAP2K1 LRRC56 HRAS BRAF
32	myeloproliferative neoplasm	30.7	U2AF1 PTPN11 NF1 HRAS
33	lymphangioma	30.6	KRAS HRAS BRAF
34	li-fraumeni syndrome	30.6	U2AF1 NF1 KRAS HRAS
35	ptosis	30.6	SOS1 SHOC2 PTPN11 CBL
36	cutaneous-skeletal hypophosphatemia syndrome	30.6	LRRC56 HRAS
37	syringocystadenoma papilliferum	30.4	HRAS BRAF
38	capillary malformation-arteriovenous malformation 1	30.3	MAP2K1 KRAS
39	noonan syndrome 14	10.9
40	lung cancer susceptibility 3	10.8	U2AF1 SOS1 RAF1 PTPN11 NRAS MAP2K1
41	skin melanoma	10.8	U2AF1 RAF1 NRAS MAP2K2 MAP2K1 LRRC56
42	gastric adenocarcinoma	10.8	RAF1 PTPN11 NRAS MAP2K2 MAP2K1 LRRC56
43	leukemia, chronic myeloid	10.8	U2AF1 RAF1 PTPN11 NRAS NF1 KRAS
44	glioblastoma	10.8	RAF1 NRAS NF1 MAP2K1 LRRC56 KRAS
45	pulmonary valve stenosis	10.8	SPRED1 SOS2 SOS1 SHOC2 PTPN11 MIR499A
46	pulmonary valve disease	10.8	SPRED1 SOS2 SOS1 SHOC2 PTPN11 MIR499A
47	pilocytic astrocytoma	10.8	SOS1 RAF1 PTPN11 NRAS NF1 KRAS
48	plasma cell neoplasm	10.8	U2AF1 PTPN11 NRAS NF1 LRRC56 KRAS
49	gastrointestinal stromal tumor	10.8	U2AF1 RAF1 NRAS NF1 MAP2K1 KRAS
50	myeloma, multiple	10.8	U2AF1 PTPN11 NRAS NF1 LRRC56 KRAS

Graphical network of the top 20 diseases related to Rasopathy:

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Symptoms & Phenotypes for Rasopathy

GenomeRNAi Phenotypes related to Rasopathy according to GeneCards Suite gene sharing:

²⁵ (show all 42)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-1	10.82	CBL HRAS KRAS BRAF
2	Decreased viability	GR00055-A-2	10.82	CBL HRAS KRAS BRAF
3	Decreased viability	GR00055-A-3	10.82	KRAS
4	Decreased viability	GR00106-A-0	10.82	KRAS
5	Decreased viability	GR00221-A-1	10.82	HRAS KRAS NF1 RAF1 NRAS
6	Decreased viability	GR00221-A-2	10.82	CBL HRAS KRAS NF1 RAF1
7	Decreased viability	GR00221-A-3	10.82	CBL HRAS NRAS
8	Decreased viability	GR00221-A-4	10.82	NF1 BRAF
9	Decreased viability	GR00249-S	10.82	NF1 BRAF
10	Decreased viability	GR00301-A	10.82	KRAS RAF1 BRAF
11	Decreased viability	GR00381-A-1	10.82	KRAS BRAF
12	Decreased viability	GR00386-A-1	10.82	NF1
13	Decreased viability	GR00402-S-2	10.82	RAF1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-111	10.15	NF1
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-112	10.15	NF1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	10.15	RAF1
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	10.15	SOS1
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-130	10.15	CBL SOS1
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-148	10.15	SOS1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	10.15	BRAF CBL NF1
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-150	10.15	RAF1
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	10.15	CBL RAF1
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-153	10.15	CBL
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-165	10.15	SOS1
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-178	10.15	PTPN11
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-186	10.15	CBL
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-201	10.15	CBL
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-204	10.15	CBL NF1
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-210	10.15	CBL
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	10.15	NF1
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	10.15	BRAF
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	10.15	RAF1
33	Increased shRNA abundance (Z-score > 2)	GR00366-A-68	10.15	SOS1
34	Increased shRNA abundance (Z-score > 2)	GR00366-A-7	10.15	PTPN11
35	Increased shRNA abundance (Z-score > 2)	GR00366-A-72	10.15	RAF1
36	Increased shRNA abundance (Z-score > 2)	GR00366-A-74	10.15	NF1
37	Increased shRNA abundance (Z-score > 2)	GR00366-A-78	10.15	PTPN11
38	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	10.15	CBL
39	Increased shRNA abundance (Z-score > 2)	GR00366-A-91	10.15	SOS1
40	Increased cell migration	GR00055-A-1	9.46	NF1
41	Increased cell migration	GR00055-A-3	9.46	NF1
42	Reduced mammosphere formation	GR00396-S	9.23	BRAF HRAS KRAS NRAS PTPN11 SHOC2

MGI Mouse Phenotypes related to Rasopathy:

⁴⁵ (show all 22)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.47	BRAF CBL HRAS KRAS LRRC56 MAP2K1
2	growth/size/body region	MP:0005378	10.45	BRAF CBL HRAS KRAS LRRC56 LZTR1
3	normal	MP:0002873	10.4	BRAF HRAS KRAS MAP2K1 MAP2K2 MIR499A
4	cardiovascular system	MP:0005385	10.39	BRAF CBL HRAS KRAS LRRC56 LZTR1
5	craniofacial	MP:0005382	10.34	BRAF CBL HRAS KRAS LZTR1 MAP2K1
6	endocrine/exocrine gland	MP:0005379	10.31	BRAF CBL HRAS KRAS MAP2K1 MAP2K2
7	neoplasm	MP:0002006	10.3	BRAF HRAS KRAS MAP2K1 MAP2K2 NF1
8	muscle	MP:0005369	10.28	BRAF CBL HRAS KRAS LZTR1 MIR499A
9	hearing/vestibular/ear	MP:0005377	10.26	BRAF CBL KRAS MAP2K1 MAP2K2 NF1
10	cellular	MP:0005384	10.26	BRAF CBL KRAS LZTR1 MAP2K1 MAP2K2
11	immune system	MP:0005387	10.25	BRAF CBL KRAS LRRC56 MRAS NF1
12	digestive/alimentary	MP:0005381	10.21	BRAF HRAS KRAS MAP2K1 MAP2K2 NF1
13	embryo	MP:0005380	10.18	BRAF KRAS MAP2K1 NF1 NRAS PTPN11
14	pigmentation	MP:0001186	10.15	BRAF CBL KRAS NF1 NRAS PTPN11
15	skeleton	MP:0005390	10.13	BRAF CBL HRAS KRAS LZTR1 MAP2K1
16	limbs/digits/tail	MP:0005371	10.12	BRAF CBL KRAS NF1 NRAS PTPN11
17	respiratory system	MP:0005388	10.1	BRAF CBL HRAS KRAS LRRC56 NF1
18	reproductive system	MP:0005389	10.07	BRAF CBL KRAS LRRC56 MAP2K1 MAP2K2
19	vision/eye	MP:0005391	10.03	BRAF KRAS MAP2K1 MAP2K2 NF1 NRAS
20	hematopoietic system	MP:0005397	9.97	BRAF CBL KRAS LZTR1 MRAS NF1
21	mortality/aging	MP:0010768	9.86	BRAF CBL HRAS KRAS LRRC56 LZTR1
22	integument	MP:0010771	9.5	BRAF CBL HRAS KRAS LRRC56 MAP2K1

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Drugs & Therapeutics for Rasopathy

Interventional clinical trials:

#	Name	Status	NCT ID
1	Familial Investigations of Childhood Cancer Predisposition	Recruiting	NCT03050268
2	Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Phase III Randomized Controlled Trial	Recruiting	NCT05361811
3	Hematological Anomalies in Children With Rasopathy	Not yet recruiting	NCT04286360

Search NIH Clinical Center for Rasopathy

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Genetic Tests for Rasopathy

Genetic tests related to Rasopathy:

#	Genetic test	Affiliating Genes
1	Rasopathy ²⁸

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Anatomical Context for Rasopathy

Organs/tissues related to Rasopathy:

MalaCards : Myeloid, Heart, Spinal Cord, Brain, B Cells, Lung, Tongue

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Publications for Rasopathy

Articles related to Rasopathy:

(show top 50) (show all 679)

#	Title	Authors	PMID	Year
1	Mutational spectrum by phenotype: panel-based NGS testing of patients with clinical suspicion of RASopathy and children with multiple café-au-lait macules. ⁶² ⁵	Castellanos E...Serra E	31573083	2020
2	Providing more evidence on LZTR1 variants in Noonan syndrome patients. ⁶² ⁵	Chinton J...Obregon MG	31825158	2020
3	Clinical and molecular characterization of children with Noonan syndrome and other RASopathies in Argentina. ⁶² ⁵	Chinton J...Obregon MG	31560489	2019
4	Prenatal ultrasound findings of rasopathies in a cohort of 424 fetuses: update on genetic testing in the NGS era. ⁶² ⁵	Stuurman KE...Rinne T	31040167	2019
5	Dominant Noonan syndrome-causing LZTR1 mutations specifically affect the Kelch domain substrate-recognition surface and enhance RAS-MAPK signaling. ⁶² ⁵	Motta M...Tartaglia M	30481304	2019
6	Clinical and mutation profile of pediatric patients with RASopathy-associated hypertrophic cardiomyopathy: results from a Chinese cohort. ⁶² ⁵	Chen H...Fu L	30732632	2019
7	ClinGen's RASopathy Expert Panel consensus methods for variant interpretation. ⁶² ⁵	Gelb BD...ClinGen RASopathy Working Group	29493581	2018
8	Craniosynostosis in patients with RASopathies: Accumulating clinical evidence for expanding the phenotype. ⁶² ⁵	Ueda K...Okamoto N	28650561	2017
9	Genotype and phenotype spectrum of NRAS germline variants. ⁶² ⁵	Altmuller F...Zenker M	28594414	2017
10	Genotype and phenotype in patients with Noonan syndrome and a RIT1 mutation. ⁶² ⁵	Kouz K...Zenker M	27101134	2016
11	Expansion of the RASopathies. ⁶² ⁵	Tidyman WE...Rauen KA	27942422	2016
12	Spectrum of mutations and genotype-phenotype analysis in Noonan syndrome patients with RIT1 mutations. ⁶² ⁵	Yaoita M...Aoki Y	26714497	2016
13	New Mutations Associated with Rasopathies in a Central European Population and Genotype-Phenotype Correlations. ⁶² ⁵	Cizmarova M...Ilencikova D	26607044	2016
14	Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome. ⁶² ⁵	Cordeddu V...Tartaglia M	26173643	2015
15	Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations. ⁶² ⁵	Peacock JD...Steensma M	25808193	2015
16	Hydrops, fetal pleural effusions and chylothorax in three patients with CBL mutations. ⁶² ⁵	Bulow L...Bartsch O	25358541	2015
17	Next-generation sequencing identifies rare variants associated with Noonan syndrome. ⁶² ⁵	Chen PC...Kucherlapati R	25049390	2014
18	Clinical and Molecular Findings of Tunisian Patients with RASopathies. ⁶² ⁵	Louati R...Rebai T	25337068	2014
19	Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations. ⁶² ⁵	Kiel C...Serrano L	24803665	2014
20	Behavioral profile in RASopathies. ⁶² ⁵	Alfieri P...Vicari S	24458522	2014
21	Are RASopathies new monogenic predisposing conditions to the development of systemic lupus erythematosus? Case report and systematic review of the literature. ⁶² ⁵	Bader-Meunier B...Cormier-Daire V	23786871	2013
22	Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome. ⁶² ⁵	Aoki Y...Matsubara Y	23791108	2013
23	NMR-based functional profiling of RASopathies and oncogenic RAS mutations. ⁶² ⁵	Smith MJ...Ikura M	23487764	2013
24	Clinical and molecular analysis of RASopathies in a group of Turkish patients. ⁶² ⁵	Simsek-Kiper PO...Boduroglu K	22420426	2013
25	Atrioventricular canal defect in patients with RASopathies. ⁶² ⁵	Digilio MC...Dallapiccola B	22781091	2013
26	A rasopathy phenotype with severe congenital hypertrophic obstructive cardiomyopathy associated with a PTPN11 mutation and a novel variant in SOS1. ⁶² ⁵	Fahrner JA...Gunay-Aygun M	22585553	2012
27	Autoimmune disease and multiple autoantibodies in 42 patients with RASopathies. ⁶² ⁵	Quaio CR...Bertola DR	22488759	2012
28	RASopathies: Clinical Diagnosis in the First Year of Life. ⁶² ⁵	Digilio MC...Dallapiccola B	22190897	2011
29	Neurocognitive, adaptive, and behavioral functioning of individuals with Costello syndrome: a review. ⁶² ⁵	Axelrad ME...Gripp KW	21495179	2011
30	PTPN11-associated mutations in the heart: has LEOPARD changed Its RASpots? ⁶² ⁵	Lauriol J...Kontaridis MI	22681964	2011
31	Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation. ⁶² ⁵	Marin TM...Kontaridis MI	21339643	2011
32	The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression. ⁵	Cuevas-Navarro A...McCormick F	34237269	2021
33	Genotype-phenotype association by echocardiography offers incremental value in patients with Noonan Syndrome with Multiple Lentigines. ⁵	Kauffman H...Banerjee A	33318624	2021
34	Whole exome sequencing of fetal structural anomalies detected by ultrasonography. ⁵	Aoi H...Matsumoto N	33144663	2021
35	Novel Variant Findings and Challenges Associated With the Clinical Integration of Genomic Testing: An Interim Report of the Genomic Medicine for Ill Neonates and Infants (GEMINI) Study. ⁵	Maron JL...Davis JM	33587123	2021
36	The Clinical impact of PTPN11 mutations in adults with acute myeloid leukemia. ⁵	Alfayez M...Borthakur G	32561839	2021
37	Mutation and Phenotypic Spectrum of Patients With RASopathies. ⁵	Lallar M...Puri RD	33452774	2021
38	Variants of SOS2 are a rare cause of Noonan syndrome with particular predisposition for lymphatic complications. ⁵	Lissewski C...Zenker M	32788663	2021
39	Diagnostic power and clinical impact of exome sequencing in a cohort of 500 patients with rare diseases. ⁵	Quaio CRDC...Baratela WADR	33258288	2020
40	A prospective study on rapid exome sequencing as a diagnostic test for multiple congenital anomalies on fetal ultrasound. ⁵	Corsten-Janssen N...van Diemen CC	32627857	2020
41	The Fetal Phenotype of Noonan Syndrome Caused by Severe, Cancer-Related PTPN11 Variants. ⁵	Malniece I...Gailite L	32794475	2020
42	Implementation of exome sequencing in fetal diagnostics-Data and experiences from a tertiary center in Denmark. ⁵	Becher N...Vogel I	32304219	2020
43	Exome sequencing in infants with congenital hearing impairment: a population-based cohort study. ⁵	Downie L...Amor DJ	31827275	2020
44	Double-chambered right ventricle complicated by hypertrophic obstructive cardiomyopathy diagnosed as Noonan syndrome. ⁵	Yamamoto M...Tsujita K	32078254	2020
45	Molecular and clinical studies in 107 Noonan syndrome affected individuals with PTPN11 mutations. ⁵	Athota JP...Shetty S	32164556	2020
46	Genotype-phenotype correlation analysis in Japanese patients with Noonan syndrome. ⁵	Shoji Y...Kawai M	31292302	2019
47	Molecular and phenotypic spectrum of Noonan syndrome in Chinese patients. ⁵	Li X...Wang X	31219622	2019
48	RAF1 variant in a patient with Noonan syndrome with multiple lentigines and craniosynostosis. ⁵	Rodriguez F...Aracena M	31145547	2019
49	Segmental schwannomatosis: characteristics in 12 patients. ⁵	Alaidarous A...Mazereeuw-Hautier J	31438995	2019
50	Coexistence of schwannomatosis and glioblastoma in two families. ⁵	Deiller C...Goizet C	31128261	2019

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Genes for Rasopathy

Genes related to Rasopathy (15 elite genes):

(show top 50) (show all 165)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	441.58	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	2057894 10594032 11704759 (more) 11992261 12058348 12161469 12325025 12529711 12634870 12717436 12826400 12960218 14644997 14676626 14974085 14982869 15001945 15121796 15240615 15273746 15385933 15389709 15470362 15520399 15539800 15689434 15690106 15710330 15723289 15834506 15842656 15889278 15928039 15948193 15951301 15956085 15985475 15987685 15996221 16166557 16263833 16358218 16377799 16399795 16498234 16638574 16643459 16733669 16804314 16830086 16924159 16987887 16990350 17020470 17143285 17177198 17339163 17515436 17546245 17641779 17661820 17875892 17972951 18080325 18241070 18286234 18328949 18331608 18372317 18378677 18470943 18562489 18678287 18758896 18759865 19008228 19017799 19020799 19047918 19077116 19125092 19179468 19251646 19352411 19449407 19506109 19509418 19568997 19582499 19737548 19795160 19927903 20186801 20308328 20493809 20535210 20577567 20651068 20718194 20954246 21106241 21204800 21339643 21340158 21407260 21526175 21533187 21567923 21590266 21677813 21784453 21803945 21910226 21910245 22058153 22190897 22315187 22371576 22420426 22465605 22488759 22555271 22585553 22681964 22711529 22781091 22822385 22848035 23312806 23321623 23334668 23457302 23513489 23584145 23624134 23673659 23756559 23771920 23799168 23813970 23832011 24037001 24039098 24150203 24183200 24225993 24401936 24451042 24628801 24718990 24754368 24767283 24803665 24820750 24891296 24896146 24935154 24939587 25097206 25331952 25337068 25395418 25595571 25708222 25722345 25862627 25914815 25917897 25937001 26084119 26203125 26242988 26607044 26673822 26742426 26785492 26817465 26918529 27030275 27069254 27276561 27521173 27562378 28074573 28084675 28098151 28125078 28483241 28921562 28991257 29084544 29493581 29907801 29988639 30266093 30417923 30868567 31040167 31219622 31324109 31560489 31827275 32164556 32561839 32627857 32794475 16199547 16467864 16533526 22253195 25804457 26456833 26457647 29437595 29533785 30896080 31573083
2	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	439.53	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	8234268 12720172 15093544 (more) 16474404 16474405 16773572 17056636 17324647 17468812 17704260 17875937 18456719 18958496 19020799 19396835 20805368 20949621 21062266 21784453 21871821 22683711 23096712 23255105 24382853 24703799 24803665 25359213 25808193 26242988 26521233 29402968 29948256 30732632 32078254 33452774 22488932
3	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	438.94	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	10064593 16585161 17603482 (more) 17603483 18241070 18505544 19357705 19568997 19953625 20052757 20679480 20683980 21339642 21440552 21784453 22190897 22389993 22465605 22824796 23312806 23321623 23877478 23885229 25862627 26266034 26918529 27040691 29084544 29493581 29948256 30204961 30417923 31030682 31292302 22821648 24777450 29907801 30157809 30732632 31145547 31560489
4	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	438.61	Pathogenic/Likely pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	17671181 19966803 21263000 (more) 22220252 22855653 23325582 23708912 24806883 26980726 27069254 27121720 27276561 28594414 29692343 29752777 31219622
5	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	438.21	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	2102266 8042262 16439621 (more) 16474404 17483702 17551924 17703371 18039235 18042262 18413255 19206169 19376813 20186801 20735442 23093928 23312806 23680146 23907581 24451042 24719372 24775816 25155755 25348715 25463315 26633545 28512244 28524057 28650561 29084544 29493581 30732632 20395089 21204800 21871821 24803665 25180280
6	CBL	Cbl Proto-Oncogene	Protein Coding	437.36	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	20694012 25358541 25952305 (more) 28589114
7	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	434.03	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴	16267129 17143282 17143285 (more) 17586837 18651097 18678287 18854871 18925667 19020799 19077116 19352411 19438935 19953625 20133692 20186801 20305546 20493809 20683980 21041952 21340158 21387466 21744363 21779504 21784453 22190897 22420426 22465605 22494877 22585553 22848035 23487764 23665959 23673306 23756559 23885229 24037001 24458522 25862627 26686981 28991257 29402968 30039904 30266093 30784236 31219622 31573083 33318624 17339331 25712082
8	LZTR1	Leucine Zipper Like Transcription Regulator 1	Protein Coding	432.96	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴	25795793 30442766 31825158 (more) 30481304 30859559 30442762 30368668 24362817 27921248 29409008 31128261 31438995 33258288 33587123
9	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	432.96	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴	1804226 12370306 16439621 (more) 17366577 17551924 18039235 18413255 18854871 19376813 21062266 22197931 24637312 25423878 26350204 26795593 28049852
10	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	432.86	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴	17981815 18039235 18413255 (more) 19376813 23885229 33452774 18042262 18456719 25487361 29493581
11	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	432.69	Pathogenic ⁵ Likely pathogenic ⁵ DISEASES inferred ¹⁴	26173643 25795793 30417923 (more) 30707178 27942422 32788663 33452774
12	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	415.15	Pathogenic ⁵ DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)	16170316 18039947 18042262 (more) 18642361 21438134 21495179 21850009 22190897 22926243 23093928 23429430 23487764 23751039 24224811
13	SHOC2	SHOC2 Leucine Rich Repeat Scaffold Protein	Protein Coding	408.87	Pathogenic ⁵ DISEASES inferred ¹⁴	19684605 22528146 21784453 (more) 23786871 22419608 22995099 23885229 21548061 22253195 20882035 21396583 23756559 22606262
14	RIT1	Ras Like Without CAAX 1	Protein Coding	406.17	Pathogenic ⁵ DISEASES inferred ¹⁴	23791108 24469055 24939608 (more) 25049390 25124994 25294908 25959749 26242988 26714497 26757980 27101134 27109146 27226556 28347726 29734338 30293990 30712878 30898653 31040167 32304219 33144663 33452774 34237269
15	LRRC56	Leucine Rich Repeat Containing 56	Protein Coding	400	Pathogenic ⁵	16170316 18039947 18042262 (more) 18642361 21438134 21495179 21850009 22190897 22926243 23093928 23429430 23487764 23751039 24224811
16	NF1	Neurofibromin 1	Protein Coding	33.18	Likely pathogenic ⁵ DISEASES inferred ¹⁴
17	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	32.22	Likely pathogenic ⁵ DISEASES inferred ¹⁴
18	MIR499A	MicroRNA 499a	RNA Gene	9.94	DISEASES inferred ¹⁴ ¹⁴ ¹⁴
19	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	7.9	DISEASES inferred ¹⁴ ¹⁴
20	SPRED1	Sprouty Related EVH1 Domain Containing 1	Protein Coding	7.74	DISEASES inferred ¹⁴
21	RASA2	RAS P21 Protein Activator 2	Protein Coding	7.55	DISEASES inferred ¹⁴
22	RRAS	RAS Related	Protein Coding	7.14	DISEASES inferred ¹⁴
23	A2ML1	Alpha-2-Macroglobulin Like 1	Protein Coding	7.04	DISEASES inferred ¹⁴
24	LUC7L2	LUC7 Like 2, Pre-MRNA Splicing Factor	Protein Coding	6.9	DISEASES inferred ¹⁴ ¹⁴
25	SHOX	Short Stature Homeobox	Protein Coding	6.86	DISEASES inferred ¹⁴
26	RASA1	RAS P21 Protein Activator 1	Protein Coding	6.83	DISEASES inferred ¹⁴
27	SYNGAP1	Synaptic Ras GTPase Activating Protein 1	Protein Coding	6.7	DISEASES inferred ¹⁴
28	ERAS	ES Cell Expressed Ras	Protein Coding	6.69	DISEASES inferred ¹⁴
29	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	6.6	DISEASES inferred ¹⁴
30	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	6.6	DISEASES inferred ¹⁴
31	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	6.53	DISEASES inferred ¹⁴
32	MYH6	Myosin Heavy Chain 6	Protein Coding	6.5	DISEASES inferred ¹⁴
33	MYBPC3	Myosin Binding Protein C3	Protein Coding	6.48	DISEASES inferred ¹⁴
34	RRAS2	RAS Related 2	Protein Coding	6.45	DISEASES inferred ¹⁴
35	MYH7	Myosin Heavy Chain 7	Protein Coding	6.41	DISEASES inferred ¹⁴
36	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	6.33	DISEASES inferred ¹⁴
37	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	6.33	DISEASES inferred ¹⁴
38	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	6.3	DISEASES inferred ¹⁴
39	PTS	6-Pyruvoyltetrahydropterin Synthase	Protein Coding	6.26	DISEASES inferred ¹⁴
40	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	6.23	DISEASES inferred ¹⁴
41	SPRY1	Sprouty RTK Signaling Antagonist 1	Protein Coding	6.18	DISEASES inferred ¹⁴
42	KAT6B	Lysine Acetyltransferase 6B	Protein Coding	6.13	DISEASES inferred ¹⁴
43	CSH2	Chorionic Somatomammotropin Hormone 2	Protein Coding	6.12	DISEASES inferred ¹⁴
44	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	6.04	DISEASES inferred ¹⁴
45	IGF1	Insulin Like Growth Factor 1	Protein Coding	6.03	DISEASES inferred ¹⁴
46	CFC1	Cripto, FRL-1, Cryptic Family 1	Protein Coding	6	DISEASES inferred ¹⁴
47	MPZL1	Myelin Protein Zero Like 1	Protein Coding	5.99	DISEASES inferred ¹⁴
48	NKX2-5	NK2 Homeobox 5	Protein Coding	5.91	DISEASES inferred ¹⁴
49	TBX5	T-Box Transcription Factor 5	Protein Coding	5.87	DISEASES inferred ¹⁴
50	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	5.78	DISEASES inferred ¹⁴

Sources

Variations for Rasopathy

ClinVar genetic disease variations for Rasopathy:

⁵ (show top 50) (show all 3123)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	CBL	NM_005188.4(CBL):c.1076_1087del (p.Asp359_Lys362del)	DEL	Pathogenic	40404	rs397507490	GRCh37: 11:119148532-119148543 GRCh38: 11:119277822-119277833
2	CBL	NM_005188.4(CBL):c.1227+2_1227+4delinsAAG	INDEL	Pathogenic	40407	rs397507493	GRCh37: 11:119149009-119149011 GRCh38: 11:119278299-119278301
3	PTPN11	NM_002834.5(PTPN11):c.179_182delinsT (p.Gly60_Asp61delinsVal)	INDEL	Pathogenic	40492	rs397507508	GRCh37: 12:112888163-112888166 GRCh38: 12:112450359-112450362
4	PTPN11	NM_002834.5(PTPN11):c.1517_1518delinsCC (p.Gln506Pro)	INDEL	Pathogenic	55799	rs397509345	GRCh37: 12:112926897-112926898 GRCh38: 12:112489093-112489094
5	PTPN11	NM_002834.5(PTPN11):c.1508G>C (p.Gly503Ala)	SNV	Pathogenic	162464	rs397507546	GRCh37: 12:112926888-112926888 GRCh38: 12:112489084-112489084
6	CBL	NM_005188.4(CBL):c.1096-4_1096-1del	DEL	Pathogenic	45197	rs397517077	GRCh37: 11:119148872-119148875 GRCh38: 11:119278162-119278165
7	CBL	NM_005188.2:c.1227+2_1227+3delTACinsAAG	INSERT	Pathogenic	180826		GRCh37: GRCh38:
8	MAP2K1	NM_002755.4(MAP2K1):c.383_384delinsTT (p.Gly128Val)	INDEL	Pathogenic	40745	rs730880508	GRCh37: 15:66729175-66729176 GRCh38: 15:66436837-66436838
9	NRAS	NM_002524.5(NRAS):c.112-1_113dup	DUP	Pathogenic	40472	rs730880967	GRCh37: 1:115256597-115256598 GRCh38: 1:114713976-114713977
10	PTPN11	NM_002834.5(PTPN11):c.209A>G (p.Lys70Arg)	SNV	Pathogenic	44603	rs397516801	GRCh37: 12:112888193-112888193 GRCh38: 12:112450389-112450389
11	SOS1	NM_005633.4(SOS1):c.1300_1301delinsAA (p.Gly434Lys)	INDEL	Pathogenic	40671	rs730881048	GRCh37: 2:39250268-39250269 GRCh38: 2:39023127-39023128
12	PTPN11	NM_002834.5(PTPN11):c.785T>G (p.Leu262Arg)	SNV	Pathogenic	40521	rs397507526	GRCh37: 12:112910776-112910776 GRCh38: 12:112472972-112472972
13	PTPN11	NM_002834.5(PTPN11):c.1506_1507delinsCC (p.Gly503Arg)	INDEL	Pathogenic	571101	rs1566186833	GRCh37: 12:112926886-112926887 GRCh38: 12:112489082-112489083
14	PTPN11	NM_002834.5(PTPN11):c.182A>C (p.Asp61Ala)	SNV	Pathogenic	179221	rs121918461	GRCh37: 12:112888166-112888166 GRCh38: 12:112450362-112450362
15	PTPN11	NM_002834.5(PTPN11):c.634_638del (p.Leu212fs)	DEL	Pathogenic	942066	rs2038127324	GRCh37: 12:112892473-112892477 GRCh38: 12:112454669-112454673
16	PTPN11	NM_002834.5(PTPN11):c.409del (p.Val137fs)	DEL	Pathogenic	961562	rs2038103354	GRCh37: 12:112891075-112891075 GRCh38: 12:112453271-112453271
17	PTPN11	NM_002834.5(PTPN11):c.1147dup (p.Met383fs)	DUP	Pathogenic	963962	rs2038606313	GRCh37: 12:112919931-112919932 GRCh38: 12:112482127-112482128
18	RAF1	NM_002880.4(RAF1):c.775T>G (p.Ser259Ala)	SNV	Pathogenic	504514	rs3730271	GRCh37: 3:12645694-12645694 GRCh38: 3:12604195-12604195
19	RAF1	NM_002880.4(RAF1):c.776C>A (p.Ser259Tyr)	SNV	Pathogenic	44633	rs397516827	GRCh37: 3:12645693-12645693 GRCh38: 3:12604194-12604194
20	SOS1	NM_005633.4(SOS1):c.1644T>A (p.Ser548Arg)	SNV	Pathogenic	40679	rs730881045	GRCh37: 2:39249925-39249925 GRCh38: 2:39022784-39022784
21	PTPN11	NC_000012.11:g.(?_112915449)_(112915825_?)del	DEL	Pathogenic	1070485		GRCh37: 12:112915449-112915825 GRCh38:
22	PTPN11	NM_002834.5(PTPN11):c.1075G>T (p.Glu359Ter)	SNV	Pathogenic	1072028		GRCh37: 12:112915802-112915802 GRCh38: 12:112477998-112477998
23	PTPN11	NM_002834.5(PTPN11):c.691C>T (p.Arg231Ter)	SNV	Pathogenic	1367799		GRCh37: 12:112893802-112893802 GRCh38: 12:112455998-112455998
24	PTPN11	NM_002834.5(PTPN11):c.18del (p.Trp6fs)	DEL	Pathogenic	1435208		GRCh37: 12:112884082-112884082 GRCh38: 12:112446278-112446278
25	PTPN11	NM_002834.5(PTPN11):c.220_221dup (p.Leu74fs)	DUP	Pathogenic	1374451		GRCh37: 12:112888202-112888203 GRCh38: 12:112450398-112450399
26	PTPN11	NC_000012.11:g.(?_112910728)_(112910864_?)del	DEL	Pathogenic	1370287		GRCh37: 12:112910728-112910864 GRCh38:
27	CBL	NM_005188.4(CBL):c.1096-1G>C	SNV	Pathogenic	45196	rs397517076	GRCh37: 11:119148875-119148875 GRCh38: 11:119278165-119278165
28	PTPN11	NM_002834.5(PTPN11):c.175A>G (p.Thr59Ala)	SNV	Pathogenic	288033	rs886043790	GRCh37: 12:112888159-112888159 GRCh38: 12:112450355-112450355
29	RAF1	NM_002880.4(RAF1):c.781C>G (p.Pro261Ala)	SNV	Pathogenic	40605	rs121434594	GRCh37: 3:12645688-12645688 GRCh38: 3:12604189-12604189
30	MAP2K1	NM_002755.4(MAP2K1):c.323G>T (p.Arg108Leu)	SNV	Pathogenic	280446	rs727504819	GRCh37: 15:66729115-66729115 GRCh38: 15:66436777-66436777
31	PTPN11	NM_002834.5(PTPN11):c.569T>A (p.Leu190Ter)	SNV	Pathogenic	966477	rs2038125958	GRCh37: 12:112892411-112892411 GRCh38: 12:112454607-112454607
32	CBL	NM_005188.4(CBL):c.1096-1G>T	SNV	Pathogenic	180815	rs397517076	GRCh37: 11:119148875-119148875 GRCh38: 11:119278165-119278165
33	PTPN11	NM_002834.5(PTPN11):c.598A>T (p.Asn200Tyr)	SNV	Pathogenic	164998	rs727503381	GRCh37: 12:112892440-112892440 GRCh38: 12:112454636-112454636
34	SOS1	NM_005633.4(SOS1):c.253T>C (p.Trp85Arg)	SNV	Pathogenic	40648	rs730881054	GRCh37: 2:39285906-39285906 GRCh38: 2:39058765-39058765
35	PTPN11	NM_002834.5(PTPN11):c.213T>G (p.Phe71Leu)	SNV	Pathogenic	477670	rs1555267558	GRCh37: 12:112888197-112888197 GRCh38: 12:112450393-112450393
36	SOS1	NM_005633.4(SOS1):c.1294T>C (p.Trp432Arg)	SNV	Pathogenic	12873	rs267607080	GRCh37: 2:39250275-39250275 GRCh38: 2:39023134-39023134
37	RAF1	NM_002880.4(RAF1):c.768G>T (p.Arg256Ser)	SNV	Pathogenic	40599	rs397516826	GRCh37: 3:12645701-12645701 GRCh38: 3:12604202-12604202
38	MAP2K2	NM_030662.4(MAP2K2):c.395G>A (p.Gly132Asp)	SNV	Pathogenic	30170	rs387906800	GRCh37: 19:4110562-4110562 GRCh38: 19:4110564-4110564
39	MAP2K1	NM_002755.4(MAP2K1):c.355C>T (p.His119Tyr)	SNV	Pathogenic	40741	rs730880503	GRCh37: 15:66729147-66729147 GRCh38: 15:66436809-66436809
40	PTPN11	NM_002834.5(PTPN11):c.417G>T (p.Glu139Asp)	SNV	Pathogenic	40512	rs397507520	GRCh37: 12:112891083-112891083 GRCh38: 12:112453279-112453279
41	PTPN11	NM_002834.5(PTPN11):c.854T>G (p.Phe285Cys)	SNV	Pathogenic	40533	rs121918463	GRCh37: 12:112915455-112915455 GRCh38: 12:112477651-112477651
42	MAP2K1	NM_002755.4(MAP2K1):c.364A>G (p.Asn122Asp)	SNV	Pathogenic	228273	rs876657651	GRCh37: 15:66729156-66729156 GRCh38: 15:66436818-66436818
43	KRAS	NM_004985.5(KRAS):c.101C>T (p.Pro34Leu)	SNV	Pathogenic	40454	rs104894366	GRCh37: 12:25398218-25398218 GRCh38: 12:25245284-25245284
44	PTPN11	NM_002834.5(PTPN11):c.172A>C (p.Asn58His)	SNV	Pathogenic	40486	rs397507505	GRCh37: 12:112888156-112888156 GRCh38: 12:112450352-112450352
45	RAF1	NM_002880.4(RAF1):c.775T>A (p.Ser259Thr)	SNV	Pathogenic	40601	rs3730271	GRCh37: 3:12645694-12645694 GRCh38: 3:12604195-12604195
46	RAF1	NM_002880.4(RAF1):c.776C>G (p.Ser259Cys)	SNV	Pathogenic	40602	rs397516827	GRCh37: 3:12645693-12645693 GRCh38: 3:12604194-12604194
47	CBL	NM_005188.4(CBL):c.1139T>C (p.Leu380Pro)	SNV	Pathogenic	477692	rs1377506801	GRCh37: 11:119148919-119148919 GRCh38: 11:119278209-119278209
48	KRAS	NM_004985.5(KRAS):c.458A>G (p.Asp153Gly)	SNV	Pathogenic	40465	rs104894360	GRCh37: 12:25362838-25362838 GRCh38: 12:25209904-25209904
49	SOS1	NM_005633.4(SOS1):c.1649T>C (p.Leu550Pro)	SNV	Pathogenic	40680	rs397517153	GRCh37: 2:39249920-39249920 GRCh38: 2:39022779-39022779
50	RAF1	NM_002880.4(RAF1):c.1457A>G (p.Asp486Gly)	SNV	Pathogenic	40618	rs397516815	GRCh37: 3:12627259-12627259 GRCh38: 3:12585760-12585760

Sources

Expression for Rasopathy

Search GEO for disease gene expression data for Rasopathy.

Sources

Pathways for Rasopathy

Pathways related to Rasopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 207)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	14.04	BRAF CBL HRAS KRAS MAP2K1 MAP2K2
2	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	14.04	BRAF CBL HRAS KRAS MAP2K1 MAP2K2
3	Apoptotic Pathways in Synovial Fibroblasts ⁶⁴ Show member pathways Actin-Based Motility by Rho Family GTPases ⁶⁴ Cellular Apoptosis Pathway ⁶⁴ DHA Signaling ⁶⁴ eIF2 Pathway ⁶⁴ ERK5 Signaling ⁶⁴ Glioma Invasiveness ⁶⁴ Mitochondrial Apoptosis ⁶⁴ Nuclear Receptor Activation by Vitamin-A ⁶⁴ p53 Mediated Apoptosis ⁶⁴ PPAR Pathway ⁶⁴ Rac1 Pathway ⁶⁴ Rap1 Pathway ⁶⁴ Telomerase Components in Cell Signaling ⁶⁴	14.01	SOS2 SOS1 RAF1 NRAS MRAS MAP2K2
4	Signal Transduction ⁶⁶	14.01	SPRED1 SOS2 SOS1 SHOC2 RIT1 RAF1
5	GPCR Pathway ⁶⁴ Show member pathways Breast Cancer Regulation by Stathmin1 ⁶⁴ Estrogen Pathway ⁶⁴ NFAT in Immune Response ⁶⁴ P2Y Receptor Signaling ⁶⁴ Pancreatic Adenocarcinoma ⁶⁴ Paxillin Interactions ⁶⁴ Ras Pathway ⁶⁴	13.89	SOS2 SOS1 RAF1 NRAS MRAS MAP2K2
6	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.82	SOS2 SOS1 RAF1 NRAS MRAS MAP2K2
7	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.79	BRAF CBL HRAS KRAS MAP2K1 MAP2K2
8	Activation of cAMP-Dependent PKA ⁶⁴ Show member pathways Activation of PKA through GPCR ⁶⁴ cAMP Pathway ⁶⁴ PKA Signaling ⁶⁴	13.76	SOS2 SOS1 RAF1 NRAS MRAS MAP2K2
9	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.73	BRAF CBL HRAS KRAS MAP2K1 MAP2K2
10	Integrin Pathway ⁶⁴ Show member pathways FAK1 Signaling ⁶⁴ GnRH Signaling ⁶⁴ Inhibition of Angiogenesis by TSP1 ⁶⁴ Transendothelial Migration of Leukocytes ⁶⁴ UPA-UPAR Pathway ⁶⁴	13.64	SOS2 SOS1 RAF1 NRAS MRAS MAP2K2
11	RAF/MAP kinase cascade ⁶⁶ Show member pathways Diseases of signal transduction by growth factor receptors and second messengers ⁶⁶ MAPK family signaling cascades ⁶⁶ MAPK1/MAPK3 signaling ⁶⁶	13.61	BRAF CBL HRAS KRAS MAP2K1 MAP2K2
12	CREB Pathway ⁶⁴ Show member pathways Activation of PKC through GPCR ⁶⁴ Intracellular Calcium Signaling ⁶⁴ IP3 Pathway ⁶⁴	13.54	SOS2 SOS1 RAF1 NRAS MRAS MAP2K2
13	Nanog in Mammalian ESC Pluripotency ⁶⁴ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶⁴ eNOS Signaling ⁶⁴ GSK3 Signaling ⁶⁴	13.54	BRAF CBL HRAS KRAS MAP2K1 MAP2K2
14	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.53	SOS2 SOS1 RAF1 NRAS MRAS KRAS
15	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.5	SOS2 SOS1 PTPN11 NRAS MAP2K1 KRAS
16	ADORA2B mediated anti-inflammatory cytokines production ⁶⁶ Show member pathways Alpha-Adrenergic Signaling ⁶⁴ Androgen receptor signaling pathway ⁷⁴ Anti-inflammatory response favouring Leishmania parasite infection ⁶⁶ Beta-agonist/Beta-blocker Pathway, Pharmacodynamics ⁶⁰ CD163 mediating an anti-inflammatory response ⁶⁶ Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation ²² G alpha (z) signalling events ⁶⁶ G protein signaling pathways ⁷⁴ Glucagon signaling in metabolic regulation ⁶⁶ GPER1 signaling ⁶⁶ Hedgehog Signaling in Mammals ⁶⁴ Leishmania infection ⁶⁶ Leishmania parasite growth and survival ⁶⁶ LTC4-CYSLTR mediated IL4 production ⁶⁶ Relaxin Pathway ⁶⁴ Signal transduction cAMP signaling ²²	13.46	BRAF HRAS KRAS MAP2K1 MAP2K2 MRAS
17	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	13.34	SOS2 SOS1 RAF1 NRAS MRAS MAP2K2
18	p70S6K Signaling ⁶⁴ Show member pathways mTOR Pathway ⁶⁴ Renin-Angiotensin Pathway ⁶⁴	13.31	SOS2 SOS1 RAF1 NRAS MRAS MAP2K2
19	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	13.2	HRAS KRAS MAP2K1 MAP2K2 NRAS RAF1
20	TCR Signaling (Qiagen) ⁶⁴ Show member pathways Fc-EpsilonRI Pathway ⁶⁴ ITK and TCR Signaling ⁶⁴ PDGF Pathway ⁶⁴ PKC-Theta Pathway ⁶⁴	13.2	SOS2 SOS1 RAF1 NRAS MRAS MAP2K2
21	Sertoli-Sertoli Cell Junction Dynamics ⁶⁴ Show member pathways Epithelial Tight Junctions ⁶⁴ Germ Cell-Sertoli Cell Junction Dynamics ⁶⁴	13.18	RAF1 NRAS MRAS MAP2K2 MAP2K1 KRAS
22	Beta-Adrenergic Signaling ⁶⁴ Show member pathways CDK5 Pathway ⁶⁴ Erythropoietin Pathway ⁶⁴ Insulin Pathway ⁷⁰ Insulin Receptor Pathway ⁶⁴	13.17	SOS2 SOS1 RAF1 NRAS MRAS MAP2K2
23	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	13.16	SOS2 SOS1 RAF1 NRAS MRAS MAP2K2
24	CCR5 Pathway in Macrophages ⁶⁴ Show member pathways Androgen Signaling ⁶⁴ Chemokine Signaling ⁶⁴ Chemokine signaling pathway ⁷⁴	13.15	BRAF HRAS KRAS MAP2K1 MRAS NRAS
25	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	13.13	SOS2 SOS1 RAF1 NRAS MAP2K2 MAP2K1
26	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	13.13	SOS2 SOS1 RAF1 NRAS MAP2K2 MAP2K1
27	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis ⁷⁴ Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis modulation by HSP70 ⁷⁴ Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ Ceramide signaling pathway ⁶¹ DR3 Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef: Negative effector of Fas and TNF-alpha ⁶¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF Signaling ⁶⁴ TNF-related weak inducer of apoptosis (TWEAK) signaling pathway ⁷⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	13.12	SOS2 SOS1 RAF1 MAP2K2 MAP2K1 HRAS
28	Signaling by Receptor Tyrosine Kinases ⁶⁶	13.11	SPRED1 SOS1 RIT1 PTPN11 NRAS MAP2K2
29	IL-9 Signaling Pathways ⁶⁵ Show member pathways Adipocytokines and Insulin Signaling ⁶⁵ Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁵ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁵ IL-2 Signaling Pathways ⁶⁵ IL-21 Signaling Pathways ⁶⁵ IL-4 Pathway ⁶⁴ IL-4 Signaling Pathways ⁶⁵ IL-7 Signaling Pathways ⁶⁵ IL-9 Pathway ⁶⁴ Immune response IL-9 signaling pathway ²² Interleukin-9 signaling ⁶⁶	13.08	BRAF CBL HRAS KRAS MAP2K1 MAP2K2
30	Alzheimer's disease and miRNA effects ⁷⁴ Show member pathways Alzheimer's disease ⁷⁴	13.07	BRAF HRAS KRAS MAP2K1 MAP2K2 NRAS
31	fMLP Pathway ⁶⁴ Show member pathways CXCR4 Pathway ⁶⁴ Huntington's Disease Pathway ⁶⁴ Internalin Pathway ⁶⁴ Signal transduction Activation of PKC via G-Protein coupled receptor ²²	13.06	SOS2 SOS1 RAF1 NRAS MRAS MAP2K2
32	Translation Insulin regulation of translation ²² Show member pathways Butyrate-induced histone acetylation ⁷⁴ Cell adhesion PLAU signaling ²² Development CNTF receptor signaling ²² Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²² Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 ⁷⁴ Regulation of lipid metabolism Insulin signaling-generic cascades ²² Transcription Receptor-mediated HIF regulation ²² Translation Regulation of EIF2 activity ²² Translation Regulation of EIF4F activity ²² Translation inhibitors in chronically activated PDGFRA cells ⁷⁴	13.03	SOS2 SOS1 RAF1 PTPN11 MAP2K2 MAP2K1
33	MAPK-Erk Pathway ⁶⁷ Show member pathways Actin Dynamics Signaling Pathway ⁶⁷ G Protein-coupled Receptors Signaling ⁶⁷	13.02	SPRED1 RAF1 NRAS MAP2K2 MAP2K1 KRAS
34	Downstream signaling of activated FGFR2 ⁶⁶ Show member pathways Activated NTRK2 signals through CDK5 ⁶⁶ Activated NTRK2 signals through FRS2 and FRS3 ⁶⁶ Activated NTRK2 signals through FYN ⁶⁶ Activated NTRK2 signals through PI3K ⁶⁶ Activated NTRK2 signals through PLCG1 ⁶⁶ Activated NTRK2 signals through RAS ⁶⁶ Activated point mutants of FGFR2 ⁶⁶ BDNF activates NTRK2 (TRKB) signaling ⁶⁶ betaKlotho-mediated ligand binding ⁶⁶ Downstream signaling of activated FGFR1 ⁶⁶ Downstream signaling of activated FGFR3 ⁶⁶ Downstream signaling of activated FGFR4 ⁶⁶ FGFR2c ligand binding and activation ⁶⁶ FGFR4 ligand binding and activation ⁶⁶ FGFR4 mutant receptor activation ⁶⁶ FRS-mediated FGFR1 signaling ⁶⁶ FRS-mediated FGFR2 signaling ⁶⁶ FRS-mediated FGFR3 signaling ⁶⁶ FRS-mediated FGFR4 signaling ⁶⁶ Inhibition of Ribosome Biogenesis by p19(ARF) ⁶⁴ NTF3 activates NTRK2 (TRKB) signaling ⁶⁶ NTF4 activates NTRK2 (TRKB) signaling ⁶⁶ NTRK2 activates RAC1 ⁶⁶ Phospholipase C-mediated cascade: FGFR1 ⁶⁶ Phospholipase C-mediated cascade; FGFR2 ⁶⁶ Phospholipase C-mediated cascade; FGFR3 ⁶⁶ Phospholipase C-mediated cascade; FGFR4 ⁶⁶ PI-3K cascade:FGFR1 ⁶⁶ PI-3K cascade:FGFR2 ⁶⁶ PI-3K cascade:FGFR3 ⁶⁶ PI-3K cascade:FGFR4 ⁶⁶ SHC-mediated cascade:FGFR1 ⁶⁶ SHC-mediated cascade:FGFR2 ⁶⁶ SHC-mediated cascade:FGFR3 ⁶⁶ SHC-mediated cascade:FGFR4 ⁶⁶ Signaling by FGFR3 in disease ⁶⁶ Signaling by FGFR4 in disease ⁶⁶ Signaling by NTRK2 (TRKB) ⁶⁶	13.01	SOS1 PTPN11 NRAS KRAS HRAS
35	G-AlphaQ Signaling ⁶⁴ Show member pathways G-AlphaI Signaling ⁶⁴ PAR4-mediated thrombin signaling events ⁶¹ Thrombin Signaling ⁶⁴	12.98	BRAF HRAS KRAS MAP2K1 MAP2K2 MRAS
36	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.98	BRAF CBL HRAS KRAS MAP2K1 MAP2K2
37	Signaling downstream of RAS mutants ⁶⁶ Show member pathways MAP2K and MAPK activation ⁶⁶ Negative regulation of MAPK pathway ⁶⁶ Paradoxical activation of RAF signaling by kinase inactive BRAF ⁶⁶ RAF activation ⁶⁶ Signaling by high-kinase activity BRAF mutants ⁶⁶ Signaling by moderate kinase activity BRAF mutants ⁶⁶ Signaling by RAF1 mutants ⁶⁶ Signaling by RAS mutants ⁶⁶	12.97	SHOC2 RAF1 NRAS MRAS MAP2K2 MAP2K1
38	G-protein signaling G-Protein alpha-i signaling cascades ²² Show member pathways Development Beta-adrenergic receptors regulation of ERK ²² G-protein signaling G-Protein alpha-s signaling cascades ²² G-protein signaling G-Protein beta/gamma signaling cascades ²² Signaling in Gap Junctions ⁶⁴	12.97	BRAF HRAS KRAS MAP2K1 MAP2K2 MRAS
39	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.96	RAF1 NRAS MRAS MAP2K2 MAP2K1 KRAS
40	G-Beta Gamma Signaling ⁶⁴ Show member pathways CRHR Pathway ⁶⁴ GHRH Signaling ⁶⁴	12.95	BRAF HRAS KRAS MAP2K1 MAP2K2 MRAS
41	Neuropathic Pain-Signaling in Dorsal Horn Neurons ⁶⁴ Show member pathways Aldosterone Signaling in Epithelial Cells ⁶⁴ Cholera Infection ⁶⁴	12.92	SOS2 SOS1 RAF1 MAP2K2 MAP2K1 KRAS
42	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways IL1 signaling pathway ⁶⁷ Immune response IL-1 signaling pathway ²² Interleukin-1 (IL-1) structural pathway ⁷⁴ Interleukin-33 signaling ⁶⁶ Interleukin-36 pathway ⁶⁶ Mucin expression in CF via TLRs, EGFR signaling pathways ²² Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.92	SOS2 SOS1 RAF1 PTPN11 MAP2K2 MAP2K1
43	Negative regulation of FGFR1 signaling ⁶⁶ Show member pathways FGFR1 ligand binding and activation ⁶⁶ FGFR1b ligand binding and activation ⁶⁶ FGFR1c and Klotho ligand binding and activation ⁶⁶ FGFR1c ligand binding and activation ⁶⁶ FGFRL1 modulation of FGFR1 signaling ⁶⁶ Negative regulation of FGFR2 signaling ⁶⁶ Negative regulation of FGFR3 signaling ⁶⁶ Negative regulation of FGFR4 signaling ⁶⁶ Signaling by activated point mutants of FGFR1 ⁶⁶ Signaling by FGFR1 ⁶⁶ Signaling by FGFR1 amplification mutants ⁶⁶ Signaling by FGFR3 ⁶⁶ Signaling by FGFR4 ⁶⁶ Spry regulation of FGF signaling ⁶⁶	12.88	SPRED1 SOS1 PTPN11 NRAS KRAS HRAS
44	Signaling by NTRKs ⁶⁶ Show member pathways Activated NTRK3 signals through PI3K ⁶⁶ Activated NTRK3 signals through PLCG1 ⁶⁶ Activated NTRK3 signals through RAS ⁶⁶ Activation of TRKA receptors ⁶⁶ NGF-independant TRKA activation ⁶⁶ NTF3 activates NTRK3 signaling ⁶⁶ NTRK3 as a dependence receptor ⁶⁶ PI3K/AKT activation ⁶⁶ Retrograde neurotrophin signalling ⁶⁶ Signaling by NTRK1 (TRKA) ⁶⁶ Signaling by NTRK3 (TRKC) ⁶⁶	12.87	BRAF HRAS KRAS MAP2K1 MAP2K2 NRAS
45	Insulin receptor signalling cascade ⁶⁶ Show member pathways Glucose homeostasis ⁷⁴ IGF1R signaling cascade ⁶⁶ IRS activation ⁶⁶ IRS-mediated signalling ⁶⁶ IRS-related events triggered by IGF1R ⁶⁶ PI3K Cascade ⁶⁶ SHC-related events triggered by IGF1R ⁶⁶ Signal attenuation ⁶⁶ Signaling by Insulin receptor ⁶⁶ Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ⁶⁶ SOS-mediated signalling ⁶⁶	12.86	SOS1 PTPN11 NRAS KRAS HRAS
46	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.86	HRAS KRAS MAP2K1 MAP2K2 NRAS PTPN11
47	Malignant pleural mesothelioma ⁷⁴	12.84	HRAS MAP2K1 MAP2K2 RAF1 SOS1
48	TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions ⁶⁵ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ TNFs bind their physiological receptors ⁶⁶ TRAF Pathway ⁶⁴	12.84	HRAS MAP2K1 MAP2K2 RAF1 SOS1 SOS2
49	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases ²² Show member pathways Cell adhesion Integrin-mediated cell adhesion and migration ²² Cell adhesion Tight junctions ²² Cytoskeleton remodeling Integrin outside-in signaling ²² Development MAG-dependent inhibition of neurite outgrowth ²²	12.83	HRAS MAP2K1 MAP2K2 RAF1 SOS1 SOS2
50	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.82	SOS2 SOS1 PTPN11 NRAS KRAS HRAS

Sources

GO Terms for Rasopathy

Cellular components related to Rasopathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	GTPase complex	GO:1905360	8.92	SOS1 HRAS

Biological processes related to Rasopathy according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.16	BRAF CBL HRAS KRAS MAP2K1 MRAS
2	visual learning	GO:0008542	10.09	NF1 KRAS BRAF
3	thymus development	GO:0048538	10.08	RAF1 MAP2K2 MAP2K1 BRAF
4	epidermal growth factor receptor signaling pathway	GO:0007173	10.06	SOS1 PTPN11 CBL BRAF
5	positive regulation of axonogenesis	GO:0050772	10.03	MAP2K2 MAP2K1 BRAF
6	thyroid gland development	GO:0030878	10.01	RAF1 MAP2K2 MAP2K1 BRAF
7	regulation of long-term neuronal synaptic plasticity	GO:0048169	10	NF1 KRAS HRAS
8	neurotrophin TRK receptor signaling pathway	GO:0048011	9.97	SOS1 RAF1 PTPN11
9	trachea formation	GO:0060440	9.92	MAP2K2 MAP2K1
10	regulation of T cell differentiation in thymus	GO:0033081	9.9	SOS2 SOS1
11	regulation of MAPK cascade	GO:0043408	9.89	SPRED1 PTPN11 NF1
12	regulation of pro-B cell differentiation	GO:2000973	9.88	SOS2 SOS1
13	regulation of Golgi inheritance	GO:0090170	9.88	MAP2K2 MAP2K1
14	epithelial cell proliferation involved in lung morphogenesis	GO:0060502	9.87	MAP2K2 MAP2K1
15	positive regulation of protein serine/threonine kinase activity	GO:0071902	9.87	SOS1 RAF1 MAP2K2 MAP2K1 KRAS
16	face development	GO:0060324	9.86	RAF1 MAP2K2 MAP2K1 BRAF
17	MAPK cascade	GO:0000165	9.86	BRAF HRAS KRAS MAP2K1 MAP2K2 NF1
18	cerebellar cortex formation	GO:0021697	9.85	MAP2K1 PTPN11
19	forebrain astrocyte development	GO:0021897	9.84	NF1 KRAS
20	regulation of axon regeneration	GO:0048679	9.83	BRAF MAP2K1 MAP2K2
21	insulin receptor signaling pathway	GO:0008286	9.81	SOS2 SOS1 RAF1 HRAS
22	insulin-like growth factor receptor signaling pathway	GO:0048009	9.67	SOS1 RAF1 MAP2K2 MAP2K1
23	positive regulation of miRNA maturation	GO:1903800	9.61	MAP2K2 MAP2K1
24	Ras protein signal transduction	GO:0007265	9.58	SOS2 SOS1 SHOC2 RIT1 NRAS NF1

Molecular functions related to Rasopathy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleotide binding	GO:0000166	9.91	RIT1 RAF1 NRAS MRAS MAP2K2 MAP2K1
2	GDP binding	GO:0019003	9.85	HRAS KRAS MRAS NRAS RIT1
3	MAP kinase kinase activity	GO:0004708	9.8	MAP2K2 MAP2K1 BRAF
4	G protein activity	GO:0003925	9.65	RIT1 NRAS MRAS KRAS HRAS
5	protein serine/threonine kinase activator activity	GO:0043539	9.23	SOS1 RAF1 MAP2K2 MAP2K1 KRAS HRAS