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MCID: RYN001
MIFTS: 48

Raynaud Disease

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Raynaud Disease

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MalaCards integrated aliases for Raynaud Disease:

Name: Raynaud Disease 58 12 45 15 17 74
Raynaud's Disease 12 44
Secondary Raynaud's Phenomenon 74
Cold Fingers, Hereditary 58
Raynaud's Syndrome 12
Raynaud Phenomenon 74

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
raynaud disease:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:10300
OMIM 58 179600
MeSH 45 D011928
SNOMED-CT 69 22954002
ICD10 34 I73.0
MedGen 43 C0034734
SNOMED-CT via HPO 70 263681008 266261006
Sources

Summaries for Raynaud Disease

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MedlinePlus : 44 Raynaud's disease is a rare disorder of the blood vessels, usually in the fingers and toes. It causes the blood vessels to narrow when you are cold or feeling stressed. When this happens, blood can't get to the surface of the skin and the affected areas turn white and blue. When the blood flow returns, the skin turns red and throbs or tingles. In severe cases, loss of blood flow can cause sores or tissue death. Primary Raynaud's happens on its own. The cause is not known. There is also secondary Raynaud's, which is caused by injuries, other diseases, or certain medicines. People in colder climates are more likely to develop Raynaud's. It is also more common in women, people with a family history, and those over age 30. Treatment for Raynaud's may include drugs to keep the blood vessels open. There are also simple things you can do yourself, such as Soaking hands in warm water at the first sign of an attack Keeping your hands and feet warm in cold weather Avoiding triggers, such as certain medicines and stress NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Raynaud Disease, also known as raynaud's disease, is related to raynaud phenomenon and scleroderma, familial progressive, and has symptoms including nausea and vomiting, constipation and fever. An important gene associated with Raynaud Disease is RCC1 (Regulator Of Chromosome Condensation 1), and among its related pathways/superpathways are Lung fibrosis and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The drugs Cilostazol and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and endothelial, and related phenotypes are abnormality of the skeletal system and raynaud phenomenon

Description from OMIM: 179600
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Related Diseases for Raynaud Disease

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Diseases related to Raynaud Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 raynaud phenomenon 32.3 EDN1 VWF
2 scleroderma, familial progressive 30.4 EDN1 TOP1
3 connective tissue disease 29.8 CENPB EDN1 TOP1
4 systemic scleroderma 29.8 CENPB EDN1 TOP1
5 complex regional pain syndrome 29.6 CALCA EDN1
6 rheumatic disease 29.4 CENPB IL1R1 TOP1
7 pulmonary hypertension 29.4 EDN1 PTGIR VWF
8 reynolds syndrome 11.4
9 vascular disease 11.3
10 aseptic meningitis 10.1 CALCA IL1R1
11 chronic pulmonary heart disease 10.1 EDN1 PTGIR
12 calcinosis 10.1
13 crest syndrome 10.1 CENPB TOP1
14 dyskinesia of esophagus 10.1 CENPB TOP1
15 limited scleroderma 10.0 CENPB TOP1
16 eisenmenger syndrome 9.9 EDN1 VWF
17 autoimmune disease of musculoskeletal system 9.9 CENPB TOP1
18 hepatic vascular disease 9.9 EDN1 VWF
19 hereditary hemorrhagic telangiectasia 9.9
20 thrombosis 9.9
21 ischemia 9.9
22 diabetes mellitus 9.9
23 collagen disease 9.9 CENPB EDN1 TOP1
24 systemic lupus erythematosus 9.9
25 rheumatoid arthritis 9.9
26 peripheral vascular disease 9.9
27 arthritis 9.9
28 diabetic angiopathy 9.9 EDN1 VWF
29 hepatopulmonary syndrome 9.8 EDN1 VWF
30 limb ischemia 9.8 EDN1 VWF
31 behcet syndrome 9.7
32 endosteal hyperostosis, autosomal dominant 9.7
33 hypertension, essential 9.7
34 yellow nail syndrome 9.7
35 neural tube defects 9.7
36 myeloperoxidase deficiency 9.7
37 anxiety 9.7
38 autoimmune disease 1 9.7
39 myocardial infarction 9.7
40 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.7
41 hepatitis 9.7
42 hepatitis b 9.7
43 hydrocephalus 9.7
44 intermittent claudication 9.7
45 keratoconus 9.7
46 familial cold autoinflammatory syndrome 9.7
47 pulmonary edema 9.7
48 telangiectasis 9.7
49 diffuse scleroderma 9.7
50 neuritis 9.7

Graphical network of the top 20 diseases related to Raynaud Disease:



Diseases related to Raynaud Disease
Sources

Symptoms & Phenotypes for Raynaud Disease

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Human phenotypes related to Raynaud Disease:

33
# Description HPO Frequency HPO Source Accession
1 abnormality of the skeletal system 33 HP:0000924
2 raynaud phenomenon 33 HP:0030880

Symptoms via clinical synopsis from OMIM:

58
Limbs:
intermittent attacks of numb and white fingers

Clinical features from OMIM:

179600

UMLS symptoms related to Raynaud Disease:


nausea and vomiting, constipation, fever, fatigue, angina pectoris, abdominal pain, edema, pruritus, pain, headache, chest pain, diarrhea, syncope, chronic pain, sciatica, icterus, coughing, vertigo/dizziness, dyspepsia, heartburn, gastrointestinal gas, symptoms, halitosis, pelvic pain, cold intolerance, joint or joint related complaint
Sources

Drugs & Therapeutics for Raynaud Disease

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Drugs for Raynaud Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 117)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
2
Acetylcholine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51-84-3 187
3 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
4 Phosphodiesterase Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
5 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
6 Phosphodiesterase 3 Inhibitors Phase 4
7 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
8 Fibrinolytic Agents Phase 4
9 Bronchodilator Agents Phase 4,Not Applicable
10 Protective Agents Phase 4,Early Phase 1,Not Applicable
11 Neuroprotective Agents Phase 4,Early Phase 1
12 Respiratory System Agents Phase 4,Not Applicable
13 Anti-Asthmatic Agents Phase 4,Not Applicable
14 Autonomic Agents Phase 4,Early Phase 1,Not Applicable
15 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
16 Neuromuscular Agents Phase 4,Phase 3,Phase 2,Not Applicable
17 abobotulinumtoxinA Phase 4,Phase 3,Phase 2,Not Applicable
18 Acetylcholine Release Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
19 Botulinum Toxins Phase 4,Phase 3,Phase 2,Not Applicable
20 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 2,Not Applicable
21 Cholinergic Agents Phase 4,Phase 3,Phase 2,Not Applicable
22 Pharmaceutical Solutions Phase 4,Phase 3,Not Applicable,Early Phase 1
23
Nitroglycerin Approved, Investigational Phase 3,Phase 2,Phase 1 55-63-0 4510
24
Nitrous oxide Approved, Vet_approved Phase 3,Not Applicable 10024-97-2 948
25
Tadalafil Approved, Investigational Phase 3,Phase 2,Not Applicable 171596-29-5 110635
26
Iloprost Approved, Investigational Phase 3,Phase 2 78919-13-8 6443959
27
Nifedipine Approved Phase 3,Early Phase 1 21829-25-4 4485
28
Sodium Citrate Approved, Investigational Phase 2, Phase 3,Phase 3,Early Phase 1 68-04-2
29
Udenafil Approved, Investigational Phase 2, Phase 3 268203-93-6 6918523
30
Amlodipine Approved Phase 2, Phase 3 88150-42-9 2162
31
Prilocaine Approved Phase 3 721-50-6 4906
32
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
33
Bupivacaine Approved, Investigational Phase 2, Phase 3 38396-39-3, 2180-92-9 2474
34
Calcium Approved, Nutraceutical Phase 3,Phase 2,Not Applicable,Early Phase 1 7440-70-2 271
35
St. John's Wort Approved, Investigational, Nutraceutical Phase 3 84082-80-4
36
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Early Phase 1 77-92-9 311
37 Fasudil Investigational Phase 3 103745-39-7
38 Hormones Phase 3,Phase 2,Not Applicable,Early Phase 1
39 Calcium, Dietary Phase 3,Phase 2,Not Applicable,Early Phase 1
40 calcium channel blockers Phase 3,Phase 2,Early Phase 1
41 Antihypertensive Agents Phase 2, Phase 3,Not Applicable,Early Phase 1
42 insulin Phase 3
43 Insulin, Globin Zinc Phase 3
44 Vardenafil Dihydrochloride Phase 2, Phase 3
45 Phosphodiesterase 5 Inhibitors Phase 2, Phase 3,Phase 3,Not Applicable,Early Phase 1
46 Tocolytic Agents Phase 3,Early Phase 1
47 Sildenafil Citrate Phase 2, Phase 3,Phase 3,Early Phase 1 171599-83-0
48 Citrate Phase 2, Phase 3,Phase 3,Early Phase 1
49 Protein Kinase Inhibitors Phase 3
50 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Phase 3

Interventional clinical trials:

(show top 50) (show all 74)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Pletal (Cilostazol) for the Treatment of Juvenile Primary and Secondary Raynaud’s Phenomenon Completed NCT00048776 Phase 4 Pletal
2 Safety and Efficacy of Pletal(Cilostazol) for the Treatment of Juvenile Primary and Secondary Raynaud’s Phenomenon Completed NCT00048763 Phase 4 Pletal
3 The Effect of Abobotulinum Toxin A on the Symptoms of Raynaud's Phenomenon Recruiting NCT03639766 Phase 4 AbobotulinumtoxinA
4 Study of a Topical Formulation for the Treatment and Prevention of Raynaud's Phenomenon Symptoms Unknown status NCT00934427 Phase 3 0.9% nitroglycerin in TAM cream;vehicle cream
5 A Study of a Topical Form of Nitroglycerin and Placebo in the Treatment and Prevention of Raynaud's Phenomenon Unknown status NCT00577304 Phase 3 Nitroglycerin;Topical AmphiMatrix
6 Efficacy of Botulinum Toxin In Scleroderma-Associated Raynaud's Syndrome Completed NCT02165111 Phase 3 Onabotulinumtoxin A;sterile saline solution
7 Effects of Vardenafil on Clinical Symptoms and Peripheral Blood Flow in Patients With Raynaud's Syndrome Completed NCT01291199 Phase 2, Phase 3 vardenafil;Placebo
8 Randomised Control Trial to Assess the Efficacy of Tadalafil in Raynaud's Phenomenon in Scleroderma Completed NCT00626665 Phase 3 Tadalafil
9 Phase III Study of Topical Gel for Treatment and Prevention of Raynaud's Phenomenon Completed NCT00266669 Phase 3 Topical organogel with nitroglycerin
10 St. John's Wort in the Treatment of Raynaud's Phenomenon Completed NCT00351117 Phase 3 St. John's Wort;Lactose
11 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Iloprost for Raynaud's Phenomenon Secondary to Systemic Sclerosis Completed NCT00004786 Phase 3 iloprost
12 Lab Study of MQX-503 in Treatment of Raynaud's Completed NCT00253331 Phase 2, Phase 3 topical organogel with nitroglycerin
13 Raynaud's Treatment Study (RTS) Completed NCT00000530 Phase 3 nifedipine
14 Phase III Study of a Topical Gel Formulation for Treatment and Prevention of Raynaud's Phenomenon Completed NCT00419419 Phase 3 Topical AmphiMatrix with nitroglycerin (MQX-503)
15 "As Required" Oral Sildenafil in Raynaud's Phenomenon Completed NCT02050360 Phase 2, Phase 3 Sildenafil 40 mg;Sildenafil 80 mg;Placebo
16 Efficacy Study of PDE-5 Inhibitor and Calcium Channel Inhibitor for the Treatment of Secondary Raynaud Phenomenon Completed NCT01280266 Phase 2, Phase 3 Udenafil or Amlodipine
17 A Rho-kinase Inhibitor (Fasudil) in the Treatment of Raynaud's Phenomenon Completed NCT00498615 Phase 3 Fasudil
18 A Randomized Control Trial to Assess the Efficacy of Tadalafil in Raynaud's Phenomenon in Scleroderma Completed NCT01117298 Phase 3 Tadalafil;Placebo
19 Effect of Sildenafil on the Microcirculatory Blood Flow and Endothelial Progenitor Cells in Systemic Sclerosis Completed NCT01347008 Phase 3 Sildenafil citrate;Placebo (Sugar pill)
20 A Study of RoActemra/Actemra (Tocilizumab) Versus Placebo in Patients With Systemic Sclerosis Completed NCT01532869 Phase 3 Placebo;tocilizumab [RoActemra/Actemra];tocilizumab [RoActemra/Actemra]
21 Efficacy of Botulinum Toxin A in Adult Subjects With Raynaud Phenomenon Secondary to Systemic Sclerosis Recruiting NCT03717961 Phase 3 BOTOX® solution;Placebo group
22 Exparel as a Nerve Block for Severe Hand Pain Terminated NCT02374320 Phase 2, Phase 3 liposomal bupivacaine
23 Safety and Efficacy Study of Gene Therapy Drug (Neovasculgen) to Treat Secondary Raynaud's Phenomenon Unknown status NCT02356809 Phase 1, Phase 2 Neovasculgen
24 Safety, Tolerability, and Pharmacodynamic Profile of Oral 2101 in Secondary Raynaud's Disease Completed NCT00528242 Phase 2 SLx-2101;Placebo
25 A Two-Part Study of BOTOX® Therapy for Ischemic Digits Completed NCT01309802 Phase 2 onabotulinum toxin type-A
26 Dose Response Study of a Topical Formulation of Nitroglycerin for the Treatment of Raynaud's Phenomenon Completed NCT00480753 Phase 2 Nitroglycerin
27 Digital Flow Enhancement in Raynaud's Phenomenon With an sGC (Soluble Guanylate Cyclase) Stimulator Completed NCT01926847 Phase 2 Riociguat (Adempas, BAY63-2521);Placebo
28 Dose Response Study of a Topical Gel for the Treatment of Raynaud's Phenomenon Completed NCT00378521 Phase 2 MQX-503
29 Efficacy and Tolerability of Ginkgo Biloba Extract in Patients With Raynaud´s Phenomenon Completed NCT00251238 Phase 2 Ginkgo biloba extract EGb 761
30 PF-00489791 For The Treatment Of Raynaud's Completed NCT01090492 Phase 2 PF-00489791;PF-00489791;PF-00489791;PF-00489791;PF-00489791;PF-00489791;PF-00489791;PF-00489791
31 Study of Acute Peripheral Vascular Effects, Safety and Tolerability in Subjects With Raynaud's Phenomenon Secondary to Systemic Sclerosis Completed NCT02228850 Phase 2 Alprostadil
32 Efficacy and Safety of Vascana® in Subjects With Secondary Raynaud's Phenomenon Completed NCT02688270 Phase 2 Vascana (0.9% nitroglycerin cream);Vehicle (placebo)
33 Trial of IC351 in Female Scleroderma Patients With Raynaud's and Sexual Dysfunction Completed NCT00707187 Phase 2 Cialis
34 Effects of Selexipag in Adults With Raynaud's Phenomenon Secondary to Systemic Sclerosis Completed NCT02260557 Phase 2 Selexipag;Placebo
35 Riociguat in Scleroderma Associated Digital Ulcers Completed NCT02915835 Phase 2 Riociguat;Placebo
36 Intravenous Iloprost in Subjects With Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis Recruiting NCT03867097 Phase 2 Placebo IV infusion;Iloprost Injection, for intravenous use
37 KD025 in Subjects With Diffuse Cutaneous Systemic Sclerosis Recruiting NCT03919799 Phase 2 KD025;Placebo
38 Brentuximab Vedotin for Systemic Sclerosis Recruiting NCT03222492 Phase 1, Phase 2
39 Early Treatment of Borderline Pulmonary Arterial Hypertension Associated With Systemic Sclerosis (SSc-APAH) Active, not recruiting NCT02290613 Phase 2 Ambrisentan;Placebo
40 Efficacy of ORM-12741 for Prevention of Raynaud's Phenomenon Terminated NCT01315899 Phase 2 ORM-12471 30mg;ORM-12471;placebo
41 Dose Response to Topical Glyceryl Trinitrate in Patients With Raynaud's Phenomenon Completed NCT00700518 Phase 1 placebo cream;Glyceryl Trinitrate;Glyceryl Trinitrate;Glyceryl Trinitrate;Glyceryl Trinitrate
42 MQX-503 Applied to the Hand Versus Nitroglycerin Ointment Applied to the Chest: A Pharmacokinetic Comparison Completed NCT00841594 Phase 1 nitroglycerin 0.9 % (MXQ-503);Nitroglycerin ointment 2%, USP
43 Prognostic Influence of Light Rheography Measurement of Patients With Secondary Raynaud Syndrome With Ulcers on Hands Unknown status NCT01378845 Not Applicable Tracleer;Prostavasin
44 PORH and Response to Cold in Raynaud's Phenomenon. Unknown status NCT02183779 Not Applicable L-NMMA and Fluconazole dermic injection
45 Treatment of Digital Ulcers in Korean Patients With Systemic Sclerosis: a Prospective Cohort Study Unknown status NCT02642146 Calcium Channel Blockers;Phosphodiesterase Inhibitors;Endothelin receptor blocker;Prostanoids;Other vasodilator
46 Psychopathology of Normal-tension Glaucoma in Hong Kong Chinese Out-patient Unknown status NCT00324181
47 Nova Cold Hands Raynaud's Disorder, a Disease Which Results in Decreased Blood Flow to the Hands and Feet. Completed NCT02615964
48 Soluble VE-cadherin and VE-cadherin Antibody in Sclerodermic Sclerosis Completed NCT02212249 Not Applicable
49 Diosmiplex (Vasculera®) in Primary and Secondary Raynaud's Phenomenon Completed NCT02683408 Not Applicable
50 Botulinum Toxin in the Treatment of Raynaud's Completed NCT01233999 Not Applicable botulinum toxin A

Search NIH Clinical Center for Raynaud Disease

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: raynaud disease

Sources

Genetic Tests for Raynaud Disease

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Anatomical Context for Raynaud Disease

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MalaCards organs/tissues related to Raynaud Disease:

42
Skin, Bone, Endothelial, T Cells, Testes, Spinal Cord, B Cells
Sources

Publications for Raynaud Disease

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Articles related to Raynaud Disease:

(show top 50) (show all 344)
# Title Authors Year
1
An Atypical Presentation of Raynaud's Disease. ( 30856621 )
2019
2
New onset acute pulmonary edema after methylergonovine given during cesarean delivery of a patient with undiagnosed Raynaud's disease. ( 30392649 )
2018
3
Vascular branches from cutaneous nerve of the forearm and hand: Application to better understanding raynaud's disease. ( 28960445 )
2018
4
Effects of Endoscopic Thoracic Sympathectomy on Raynaud's Disease. ( 29327980 )
2018
5
The importance of perfusion index monitoring in evaluating the efficacy of stellate ganglion blockage treatment in Raynaud's disease. ( 29350104 )
2018
6
Hyperbaric oxygen therapy for digital ulcers due to Raynaud's disease. ( 30397635 )
2018
7
A Review of Raynaud's Disease. ( 27311222 )
2016
8
Severe Primary Raynaud's Disease Treated with Rituximab. ( 27651971 )
2016
9
Raynaud disease. ( 24211176 )
2014
10
Xerosis cutis: a common predicament of Raynaud's disease. ( 24933844 )
2014
11
A case of recurrent complex regional pain syndrome accompanying Raynaud's disease: a prospective coincidence? ( 23720085 )
2013
12
Exercise using the Wii Fit plus with a child with primary Raynaud's disease and obesity: a case report. ( 23414388 )
2013
13
Syncope and Raynaud's disease. ( 22248476 )
2012
14
The use of noninvasive angiography for digital ischemia in Raynaud's disease. ( 22711208 )
2012
15
Cervical spinal cord stimulation with 5-column paddle lead in Raynaud's disease. ( 22828684 )
2012
16
Percutaneous bipolar radiofrequency T3 sympathicotomy in Raynaud's disease -A case report-. ( 23198043 )
2012
17
Classification of Raynaud's disease based on angiographic features. ( 21704575 )
2011
18
You're the flight surgeon: Raynaud's disease. ( 21961408 )
2011
19
Intraoral telangiectasias associated with Raynaud disease: a report of two cases. ( 19907728 )
2010
20
Mayo Clinic office visit. Raynaud's disease. An interview with Kevin Moder, M.D. ( 20980938 )
2010
21
Sequential bipolar radiofrequency lumbar sympathectomy in Raynaud's disease -A case report-. ( 21057622 )
2010
22
Dynamic Doppler evaluation of the hand arteries of the patients with Raynaud's disease. ( 19238503 )
2009
23
Gradual digital lengthening with autologous bone graft and external fixation for correction of flail toe in a patient with Raynaud's disease. ( 19577729 )
2009
24
Use of Equine Derived Pericardium as a Biological Cover To Promote Closure of a Complicated Wound With Associated Scleroderma and Raynaud's Disease . ( 25902774 )
2009
25
Improvement in both Raynaud disease and hyperhidrosis in response to botulinum toxin type A treatment. ( 18627700 )
2008
26
Oxidant/antioxidant status in patients with Raynaud's disease. ( 18463765 )
2008
27
Long-term effects of thoracic sympathectomy on microcirculation in the hands of patients with primary Raynaud disease. ( 17532934 )
2007
28
High resolution 3 Tesla contrast-enhanced MR angiography of the hands in Raynaud's disease. ( 16538393 )
2007
29
Raynaud's disease. Cold hands, slowed blood flow. ( 17595712 )
2007
30
Successful long-term treatment of a patient with long-standing Raynaud's disease by an extradural bupivacaine block. ( 18020090 )
2007
31
Do the telangiectases of hereditary hemorrhagic telangiectasia and the calcinosis, Raynaud's disease, sclerodactyly, telangiectasia variant of scleroderma have a common etiology? ( 16902282 )
2006
32
Anakinra prevents symptoms of familial cold autoinflammatory syndrome and Raynaud's disease. ( 16981288 )
2006
33
Phosphodiesterase type 5 inhibition is a novel therapeutic option in Raynaud disease. ( 16432094 )
2006
34
The patient with cold hands: understanding Raynaud's disease. ( 17124789 )
2006
35
Successful use of spinal cord stimulation in the treatment of severe Raynaud's disease of the hands. ( 15618807 )
2005
36
Contribution of prostanoids to endothelium-dependent vasodilatation in the digital circulation of women with primary Raynaud's disease. ( 15769250 )
2005
37
The effects of capecitabine in Raynaud's disease: a case report. ( 15788442 )
2005
38
Mechanisms of Raynaud's disease. ( 16444858 )
2005
39
Nailfold digital capillaroscopy in 447 patients with connective tissue disease and Raynaud's disease. ( 14678534 )
2004
40
Increased tyrosine phosphorylation mediates the cooling-induced contraction and increased vascular reactivity of Raynaud's disease. ( 15146428 )
2004
41
Differentiation of primary and secondary Raynaud's disease by carotid arterial stiffness. ( 12651172 )
2003
42
Raynaud's disease. ( 12814733 )
2003
43
Basics of Compounding for Raynaud's Disease. ( 23979700 )
2003
44
Diabetes mellitus vs. Raynaud disease: different lung vascular bed disorders. ( 12505097 )
2002
45
Images in clinical medicine. Acute episode of Raynaud's disease. ( 12324555 )
2002
46
Adventitial stripping of the radial and ulnar arteries in Raynaud's disease. ( 12457360 )
2002
47
The use of Ginkgo biloba in Raynaud's disease: a double-blind placebo-controlled trial. ( 12710841 )
2002
48
By the way, doctor... I am 48 and was diagnosed as having Raynaud's disease about 20 years ago. When I go outside during the winter, my fingers turn white and hurt. Is there anything new to help me? ( 11684501 )
2001
49
Acute vasospastic attack after extradural block in a patient with Raynaud's disease. ( 10825332 )
2000
50
The use of digital artery sympathectomy as a salvage procedure for severe ischemia of Raynaud's disease and phenomenon. ( 10048533 )
1999
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Variations for Raynaud Disease

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Expression for Raynaud Disease

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Search GEO for disease gene expression data for Raynaud Disease.
Sources

Pathways for Raynaud Disease

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Pathways related to Raynaud Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Lung fibrosis 1
11.06 CALCA EDN1
2
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 62
10.86 PTGIR VWF
3
Prostaglandin Synthesis and Regulation 1
10.43 EDN1 PTGIR
4
Endothelin Pathways 1
10.33 CALCA EDN1 PTGIR
Sources

GO Terms for Raynaud Disease

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Cellular components related to Raynaud Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Weibel-Palade body GO:0033093 8.62 EDN1 VWF

Biological processes related to Raynaud Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.33 CALCA EDN1 PTGIR
2 inflammatory response GO:0006954 9.32 IL1R1 PTGIR
3 regulation of blood pressure GO:0008217 9.26 CALCA EDN1
4 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 8.96 CALCA EDN1
5 positive regulation of cytosolic calcium ion concentration GO:0007204 8.8 CALCA EDN1 PTGIR
Sources

Sources for Raynaud Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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