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PIRA
MCID: RCT015
MIFTS: 60

Reactive Arthritis (PIRA)

Categories: Bone diseases, Gastrointestinal diseases, Immune diseases, Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Reactive Arthritis

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MalaCards integrated aliases for Reactive Arthritis:

Name: Reactive Arthritis 12 73 20 58 15 17
Postdysenteric Arthropathy 12 32
Arthritis, Reactive 44 70
Reiter Syndrome 20 70
Reiter Disease 12 32
Post-Infectious Reactive Arthropathy 20
Fiessinger Leroy Reiter Syndrome 12
Post-Dysenteric Arthropathy 70
Post-Bacterial Arthropathy 12
Post-Infectious Arthritis 20
Fiessinger-Leroy Disease 58
Polyarthritis Enterica 58
Arthritis Urethritica 58
Arthritis, Venereal 70
Venereal Arthritis 58
Arthritis Reactive 54
Reiter's Syndrome 20
Reiter's Disease 12
Reiters Syndrome 54
Pira 20

Characteristics:

Orphanet epidemiological data:

58
reactive arthritis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Bone diseases Immune diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare systemic and rhumatological diseases


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Summaries for Reactive Arthritis

About this section
GARD : 20 Reactive arthritis is a type of infectious arthritis that occurs as a "reaction" to an infection elsewhere in the body. This process may occur weeks or even months after the infection has resolved. In addition to joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes ( conjunctivitis ) and inflammation of the urinary tract ( urethritis ). These symptoms may occur alone, together, or not at all. The symptoms of reactive arthritis usually last 3 to 12 months, although symptoms can return or develop into a long-term disease in a small percentage of people. The exact cause of reactive arthritis is unknown. It may follow an infection with Salmonella enteritidis, Salmonella typhimurium, Yersinia enterocolitica, Campylobacter jejuni, Clostridium difficile, Shigella sonnei, Entamoeba histolytica, Cryptosporidium, or Chlamydia trachomatis. Certain genes may make you more prone to the syndrome. For instance, the condition is observed more commonly in patients with human lymphocyte antigen B27 (HLA-B27) histocompatibility antigens. The goal of treatment is to relieve symptoms and treat any underlying infection. Antibiotics may be prescribed. Nonsteroidal anti-inflammatory drugs (NSAIDS), pain relievers, and corticosteroids may be recommended for those with joint pain.

MalaCards based summary : Reactive Arthritis, also known as postdysenteric arthropathy, is related to septic arthritis and shigellosis. An important gene associated with Reactive Arthritis is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Rifampicin and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and monocytes, and related phenotypes are arthritis and joint stiffness

Disease Ontology : 12 An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.

Wikipedia : 73 Reactive arthritis, formerly known as Reiter's syndrome, is a form of inflammatory arthritis that... more...

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Related Diseases for Reactive Arthritis

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Diseases related to Reactive Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 902)
# Related Disease Score Top Affiliating Genes
1 septic arthritis 32.1 TNF TLR4 TLR2 IFNG CRP
2 shigellosis 31.9 TNF TLR4 LTF IL1B IL10
3 spondyloarthropathy 1 31.4 TNF TLR4 PRTN3 IL6 IL17A HSPD1
4 spondylarthropathy 31.2 TNF TLR4 HLA-B
5 enterocolitis 31.1 TNF TLR4 IL6 IL10
6 conjunctivitis 31.1 TNF TLR4 IL6 IL10 IFNG HLA-B
7 spondyloarthropathy 31.0 TNF IL6 IL1B IL17A IL10 IFNG
8 rheumatic fever 31.0 TNF TLR2 IL6 IL10 IFNG HP
9 enthesopathy 30.7 TNF CRP CCR6
10 synovitis 30.7 TNF PRTN3 MMP8 IL6 IL1B CRP
11 erythema multiforme 30.7 TNF IL6 IFNG
12 uveitis 30.6 TNF IL6 IL1B IL17A IL10 IFNG
13 chlamydia 30.6 TNF TLR4 TLR2 IL6 IL1B IL17A
14 plague 30.5 TNF TLR4 TLR2 IL6 IL1B IL10
15 erythema nodosum 30.5 TNF IL6 IL1B IL10 IFNG CRP
16 pharyngitis 30.5 TNF IL6 IL1B CRP
17 hidradenitis 30.5 TNF IL1B IL17A IFNG
18 hidradenitis suppurativa 30.5 TNF IL1B IL17A IFNG
19 gout 30.5 TNF TLR4 IL6 IL1B
20 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.5 IL17A IL10 IFNG
21 diarrhea 30.5 TNF TLR4 IL6 IL1B IL10 IFNG
22 arthropathy 30.5 TNF IL6 IL1B IFNG HLA-B CRP
23 gastroenteritis 30.4 TNF IL6 IL1B IL10 IFNG CRP
24 clostridium difficile colitis 30.4 LTF IL1B CRP CCR6
25 multifocal choroiditis 30.4 TNF IL10
26 urethritis 30.4 TNF TLR4 TLR2 IL6 IL1B IL10
27 poliomyelitis 30.4 TNF IL10 IFNG
28 bursitis 30.4 TNF IL6 IL1B CRP
29 posterior uveitis 30.4 TNF IL6 IFNG CCR6
30 spondylitis 30.4 TNF IL6 IL1B IL17A IL10 IFNG
31 tendinitis 30.3 TNF PRTN3 IL6 IL1B CRP
32 tenosynovitis 30.3 TNF PRTN3 IL6 IL1B HSPD1 CRP
33 prostatitis 30.3 TNF IL6 IL1B IL17A IL10
34 choroiditis 30.3 TNF IL17A IL10 IFNG
35 neurosyphilis 30.3 TLR2 IL17A IL10
36 glossitis 30.3 TNF IL6 IL1B
37 osteoarthritis 30.3 TNF IL6 IL1B IL17A CRP
38 guillain-barre syndrome 30.3 TNF IL17A HP
39 haemophilus influenzae 30.3 TNF TLR2 OMP LTF
40 streptococcal toxic-shock syndrome 30.3 TNF IL6
41 pyuria 30.2 PRTN3 IL6 CRP
42 cervicitis 30.2 TNF TLR4 IL6 IL1B IL10 HSPD1
43 fasciitis 30.2 TNF IL6 IFNG
44 urinary tract infection 30.2 TLR4 CRP
45 juvenile arthritis 30.2 IL6 IL10 CRP
46 acne 30.2 TNF TLR2 IL6 IL1B
47 keratoconjunctivitis 30.1 TNF IL6 IL17A IFNG
48 juvenile rheumatoid arthritis 30.1 TNF IL6 IL1B IL10 IFNG CRP
49 pustulosis of palm and sole 30.1 TNF IL17A CRP CCR6
50 pertussis 30.1 TNF TLR4 IL6 IL1B IL10

Graphical network of the top 20 diseases related to Reactive Arthritis:



Diseases related to Reactive Arthritis
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Symptoms & Phenotypes for Reactive Arthritis

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Human phenotypes related to Reactive Arthritis:

58 31 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthritis 58 31 hallmark (90%) Very frequent (99-80%) HP:0001369
2 joint stiffness 58 31 hallmark (90%) Very frequent (99-80%) HP:0001387
3 cognitive impairment 58 31 hallmark (90%) Very frequent (99-80%) HP:0100543
4 hyperkeratosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000962
5 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
6 joint swelling 58 31 hallmark (90%) Very frequent (99-80%) HP:0001386
7 conjunctivitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000509
8 osteomyelitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002754
9 cartilage destruction 58 31 hallmark (90%) Very frequent (99-80%) HP:0100773
10 dystrophic fingernails 58 31 hallmark (90%) Very frequent (99-80%) HP:0008391
11 diarrhea 58 31 hallmark (90%) Very frequent (99-80%) HP:0002014
12 pustule 58 31 hallmark (90%) Very frequent (99-80%) HP:0200039
13 recurrent aphthous stomatitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0011107
14 enthesitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0100686
15 inflammation of the large intestine 58 31 frequent (33%) Frequent (79-30%) HP:0002037
16 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
17 abnormal pleura morphology 31 frequent (33%) HP:0002103
18 respiratory insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0002093
19 photophobia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000613
20 fever 58 31 occasional (7.5%) Occasional (29-5%) HP:0001945
21 pulmonary fibrosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002206
22 recurrent urinary tract infections 58 31 occasional (7.5%) Occasional (29-5%) HP:0000010
23 pericarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001701
24 weight loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0001824
25 aortic regurgitation 58 31 occasional (7.5%) Occasional (29-5%) HP:0001659
26 abnormality of the nail 58 Very frequent (99-80%)
27 abnormality of the pleura 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Reactive Arthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 CCR6 CRP HP IFNB1 IFNG IL10
2 hematopoietic system MP:0005397 10.33 CCR6 HP HSPD1 IFNB1 IFNG IL10
3 immune system MP:0005387 10.31 CCR6 CRP HP IFNB1 IFNG IL10
4 cardiovascular system MP:0005385 10.22 CRP HP HSPD1 IFNG IL10 IL1B
5 integument MP:0010771 10.02 HSPD1 IFNG IL10 IL17A IL1B IL6
6 neoplasm MP:0002006 10 HP IFNB1 IFNG IL10 IL1B IL6
7 liver/biliary system MP:0005370 9.97 HP IFNG IL10 IL6 LBP LTF
8 no phenotypic analysis MP:0003012 9.7 IFNB1 IFNG IL10 IL17A OMP PRTN3
9 respiratory system MP:0005388 9.61 HSPD1 IFNG IL10 IL17A IL6 OMP
10 skeleton MP:0005390 9.32 IFNB1 IFNG IL10 IL17A IL1B IL6
Sources

Drugs & Therapeutics for Reactive Arthritis

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Drugs for Reactive Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampicin Approved Phase 3 13292-46-1 5381226 5458213
2
Azithromycin Approved Phase 3 83905-01-5 447043 55185
3
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
4 Antibiotics, Antitubercular Phase 3
5 Antiparasitic Agents Phase 3
6 Antimalarials Phase 3
7 Antitubercular Agents Phase 3
8 Antiprotozoal Agents Phase 3
9
Infliximab Approved Phase 2 170277-31-3
10 Antirheumatic Agents Phase 2
11 Dermatologic Agents Phase 2
12 Interferon-gamma Phase 2
13 interferons Phase 2
14 Antiviral Agents Phase 2
15
Roxithromycin Approved, Investigational, Withdrawn 80214-83-1 6915744 444037
16
Ofloxacin Approved 82419-36-1 4583
17
Levofloxacin Approved, Investigational 100986-85-4 149096
18
Rifaximin Approved, Investigational 80621-81-4 6436173 46783403
19 Cytochrome P-450 Enzyme Inhibitors
20 Gastrointestinal Agents
21 Anti-Bacterial Agents
22 Anti-Infective Agents
23 Anesthetics

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Phase 3 Trial to Assess the Efficacy of Long-term (6 Months) Combination Antibiotics as a Treatment for Chlamydia-induced Reactive Arthritis Completed NCT00351273 Phase 3 Doxycycline and Rifampin;Azithromycin and Rifampin;Placebo
2 New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis: Immunostimulation Plus Antibiotic Versus Immunosuppression Plus Antibiotic Versus Conventional Standardtherapy Unknown status NCT00244179 Phase 2 interferon-gamma;infliximab;dmard
3 Double-Blind, Placebo-Controlled Study of Three-Month Treatment With the Combination of Ofloxacin and Roxithromycin in Recent-Onset Reactive Arthritis Completed NCT00621387 ofloxacin and roxithromycin;placebo
4 Late Cardial Assessment in Children Who Were Diagnosed With Post Streptococcal Reactive Arthritis - a Long Term Study Completed NCT01179451
5 A Bicentre Retrospective Study of Features and Outcomes of Patients With Reactive Arthritis Completed NCT03926429
6 Prognostic Indicators and Determinants of the 2-5 Year Outcome in a Cohort of Early Synovitis Patients Completed NCT00001679
7 The Pathogenesis of Inflammatory Synovitis: A Study of Early Arthritis Completed NCT00001375
8 Rheumatology Patient Registry and Biorepository Recruiting NCT04402086
9 A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial Evaluating Two Dose Regimens of Rifaximin (550 mg Daily or 550 mg Twice Daily) for Chemoprophylaxis Against Travelers' Diarrhea (TD) Among Active Duty Deployed U.S. and British Military Personnel Active, not recruiting NCT02498301 Rifaximin;Placebo
10 Testing of an Educational Tool for Patients With Melanoma and Concomitant Autoimmune Disease Who Are Candidates for Adjuvant Therapy With Immune Checkpoint Inhibitors: Acceptability and Usability With Patients and Providers Not yet recruiting NCT04751396
11 A Pilot Randomized Control Trial Testing the Acceptability and Feasibility of a Pediatric Interactive Relational Agent (PIRA) vs. Standard Preoperative Education Not yet recruiting NCT04586569

Search NIH Clinical Center for Reactive Arthritis

Cochrane evidence based reviews: arthritis, reactive

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Genetic Tests for Reactive Arthritis

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Anatomical Context for Reactive Arthritis

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MalaCards organs/tissues related to Reactive Arthritis:

40
T Cells, Skin, Monocytes, Neutrophil, Endothelial, Eye, Myeloid
Sources

Publications for Reactive Arthritis

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Articles related to Reactive Arthritis:

(show top 50) (show all 2750)
# Title Authors PMID Year
1
Evaluation of the appropriateness of composite disease activity measures for assessment of psoriatic arthritis. 61 54
19762363 2010
2
[Some proteins of acute phase of inflammation in differential diagnostics of rheumatoid arthritis]. 61 54
18720714 2008
3
Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage damage and/or the therapeutic efficacy of treatments. 54 61
17894003 2007
4
Serum levels of cartilage oligomeric matrix protein (COMP): a rapid decrease in patients with active rheumatoid arthritis undergoing intravenous steroid treatment. 61 54
16485108 2006
5
Undifferentiated spondyloarthropathy in Chinese patients. 61 54
16513489 2006
6
Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis. 54 61
15878901 2005
7
Serum levels of cartilage oligomeric matrix protein are elevated in rheumatoid arthritis, but not in inflammatory rheumatic diseases such as psoriatic arthritis, reactive arthritis, Raynaud's syndrome, scleroderma, systemic lupus erythematosus, vasculitis and Sjögren's syndrome. 61 54
15059267 2004
8
Importance of species-specific antigens in the serodiagnosis of Chlamydia trachomatis reactive arthritis. 61 54
12209035 2002
9
IgM, IgG, and IgA response to enterobacteria in patients with ankylosing spondylitis in southern India. 54 61
12021151 2002
10
Multispecific CD4+ T cell response to a single 12-mer epitope of the immunodominant heat-shock protein 60 of Yersinia enterocolitica in Yersinia-triggered reactive arthritis: overlap with the B27-restricted CD8 epitope, functional properties, and epitope presentation by multiple DR alleles. 54 61
10640771 2000
11
BPI-ANCA is found in reactive arthritis caused by Yersinia and Salmonella infection and recognise exclusively the C-terminal part of the BPI molecule. 61 54
11028843 2000
12
Anti-lactoferrin antibodies and other types of anti-neutrophil cytoplasmic antibodies (ANCA) in reactive arthritis and ankylosing spondylitis. 61 54
10469064 1999
13
Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue. 61 54
10211878 1999
14
TAP2 alleles in inflammatory arthritis. 54 61
9645419 1998
15
Identification and characterization of a DR4-restricted T cell epitope within chlamydia heat shock protein 60. 54 61
9328119 1997
16
Antigen-dependent B cell differentiation in the synovial tissue of a patient with reactive arthritis. 54 61
9131588 1997
17
Prediction of diagnosis in acute and subacute oligoarthritis of unknown origin. 54 61
8624640 1996
18
[Blood prolactin under the effect of protirelin in spondylarthropathies. Treatment trial of 4 cases of reactive arthritis and 2 cases of psoriatic arthritis with bromocriptine]. 54 61
8763085 1996
19
TAP1 and TAP2 polymorphism in HLA-B27-positive subpopulations: no allelic differences in ankylosing spondylitis and reactive arthritis. 61 54
8770637 1995
20
Oncogene expression in synovial fluid cells in reactive and early rheumatoid arthritis: a brief report. 61 54
7582717 1995
21
Lipopolysaccharide binding protein as a marker of inflammation in synovial fluid of patients with arthritis: correlation with interleukin 6 and C-reactive protein. 61 54
7562749 1995
22
[Prolactin response to protirelin in reactive arthritis and ankylosing spondyloarthritis. Failure of treatment of 4 reactive arthritis with bromocriptine]. 61 54
7858584 1994
23
In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis. 61 54
7923879 1994
24
[Relative hyperprolactinemia under protirelin in reactive arthritis. Preliminary results]. 61 54
7971809 1994
25
Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis. 54 61
8192476 1994
26
Responses to gram negative enteric bacterial antigens by synovial T cells from patients with juvenile chronic arthritis: recognition of heat shock protein HSP60. 61 54
7693941 1993
27
Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. 54 61
1634773 1992
28
IgG and IgA antibody responses against porins in Yersinia-triggered reactive arthritis. 61 54
1316199 1992
29
Cytidine deaminase and lactoferrin in inflammatory synovial fluids. Indicators of local polymorphonuclear cell function? 54 61
1555038 1992
30
Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis, and systemic lupus erythematosus. 54 61
1384103 1992
31
Does reduced erythrocyte C3b receptor (CR1) activity contribute to the pathogenesis of yersinia triggered reactive arthritis? 61 54
1531747 1992
32
Salmonella-specific antibodies in reactive arthritis. 54 61
1955713 1991
33
Analysis of function-associated receptor molecules on peripheral blood and synovial fluid granulocytes from patients with rheumatoid and reactive arthritis. 61 54
1918267 1991
34
[A comparative study of serum complement (C3 and C4) in inflammatory joint diseases]. 54 61
1706901 1990
35
Reactive arthritis: an unusual presentation of acute Clostridioides difficile colitis. 61
33795278 2021
36
COVID-19 and the clinical course of rheumatic manifestations. 61
33733315 2021
37
Suspecting and Diagnosing the Patient with Spondyloarthritis and What to Expect from Therapy. 61
33589106 2021
38
Prevalence of anti-cyclic citrullinated peptide antibodies in patients with spondyloarthritis: A retrospective study. 61
32340503 2021
39
A retrospective case series of 12 patients with chronic reactive arthritis with emphasis on treatment outcome with biologics. 61
31293276 2021
40
Reactive arthritis after COVID-19. 61
33653867 2021
41
[Postinfectious reactive arthritis after chlamydia infection in competitive sports : Clinical management and current literature review]. 61
32583060 2021
42
Spondyloarthritis and Outcomes in Pregnancy and Labor: A Nationwide Register-Based Cohort Study. 61
31758739 2021
43
Lyme Disease among Patients at an Ambulatory Unit in a Highly Endemic Country: Lithuania. 61
33669940 2021
44
Tenosynovitis has a high sensitivity for early ACPA-positive and ACPA-negative RA: a large cross-sectional MRI study. 61
33547063 2021
45
Update on Post-Streptococcal Reactive Arthritis: Narrative Review of a Forgotten Disease. 61
33569668 2021
46
NKG2D ligands in inflammatory joint diseases: analysis in human samples and mouse models. 61
33427619 2021
47
Prevalence and distribution of peripheral musculoskeletal manifestations in spondyloarthritis including psoriatic arthritis: results of the worldwide, cross-sectional ASAS-PerSpA study. 61
33462157 2021
48
Axial presentation of reactive arthritis secondary to Covid-19 infection. 61
33471106 2021
49
Pan-genomics, drug candidate mining and ADMET profiling of natural product inhibitors screened against Yersinia pseudotuberculosis. 61
33321204 2021
50
Predicting functional disability in patients with spondyloarthritis using a CRP-based algorithm: A 3-year prospective study. 61
33363600 2021
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Variations for Reactive Arthritis

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Expression for Reactive Arthritis

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Search GEO for disease gene expression data for Reactive Arthritis.
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Pathways for Reactive Arthritis

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Pathways related to Reactive Arthritis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.87 TNF TLR4 TLR2 PRTN3 MMP8 LTF
2
PEDF Induced Signaling 63
Show member pathways
 13.73 TNF TLR4 IL6 IL1B IL17A IL10
3
Akt Signaling 63
Show member pathways
 13.47 TNF TLR4 TLR2 IL6 IL1B IL17A
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.45 TNF PRTN3 LBP IL6 IL1B IL17A
5
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.3 TNF TLR4 TLR2 LBP IL6 IL1B
6
PI3K-Akt signaling pathway 36
Show member pathways
 13.05 TNF TLR4 TLR2 IL6 IFNB1 HLA-B
7
Human cytomegalovirus infection 36
Show member pathways
 13.03 TNF TLR4 TLR2 IL6 IL1B IFNB1
8
Allograft rejection 1 36
Show member pathways
 12.96 TNF IL6 IL1B IL17A IL10 IFNG
9
Measles 36
Show member pathways
 12.93 TNF TLR4 TLR2 IL6 IL1B IFNG
10
Herpes simplex virus 1 infection 36
12.9 TNF TLR2 IL6 IL1B IFNG IFNB1
11
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.81 TNF TLR4 TLR2 IL6 IL1B IFNB1
12
Salmonella infection (KEGG) 36
Show member pathways
 12.79 TNF TLR4 TLR2 IL6 IL1B
13
NF-KappaB Family Pathway 63
Show member pathways
 12.75 TNF TLR4 TLR2 IL6 IL1B
14
T cell receptor signaling pathway 36
Show member pathways
 12.73 TNF TLR4 TLR2 IL6 IL1B IL17A
15
Th17 cell differentiation 36
Show member pathways
 12.72 TNF TLR4 TLR2 IL6 IL1B IL17A
16
Immune response IL-23 signaling pathway 23
Show member pathways
 12.69 TNF IL6 IL1B IL17A IL10 IFNG
17
NF-kappaB Signaling 4
12.66 TNF TLR2 IL1B IL17A IL10 IFNG
18
IL-17 Family Signaling Pathways 64
Show member pathways
 12.45 TNF TLR2 IL6 IL1B IL17A IFNG
19
Shigellosis 36
12.44 TNF TLR4 IL1B IFNB1
20
Folate Metabolism 1
Show member pathways
 12.43 TNF IL6 IL1B IFNG CRP
21
Defensins 65
Show member pathways
 12.43 TLR2 PRTN3 LTF CCR6 BPI
22
Toll Comparative Pathway 63
Show member pathways
 12.43 TNF TLR4 LBP IL6 IL1B IFNG
23
Toxoplasmosis 36
Show member pathways
 12.39 TNF TLR4 TLR2 IL1B IL10 IFNG
24
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.38 TNF IL6 IL10 CCR6
25
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.38 TNF IL6 IL1B IL17A IL10 IFNG
26
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.37 TNF TLR4 TLR2 IL6 IFNB1
27
NOD-like receptor signaling pathway 36
12.34 TNF TLR4 IL6 IL1B IFNB1
28
Necroptosis 36
Show member pathways
 12.31 TNF TLR4 IL1B IFNG IFNB1
29
Colorectal Cancer Metastasis 63
12.29 TNF TLR4 TLR2 IL6 IFNG
30
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.28 TNF IL6 IL1B IL10 HSPD1
31
C-type lectin receptor signaling pathway 36
Show member pathways
 12.27 TNF IL6 IL1B IL10
32
Yersinia infection 36
12.23 TNF TLR4 IL6 IL1B IL10 IFNB1
33
Bacterial infections in CF airways 23
Show member pathways
 12.19 TNF TLR4 TLR2 LBP IL6 IL1B
34
Osteoclast differentiation 36
12.13 TNF IL1B IFNG IFNB1
35
Spinal Cord Injury 1
12.13 TNF TLR4 IL6 IL1B IFNG
36
Interleukin-4 and 13 signaling 65
12.13 TNF LBP IL6 IL1B IL17A IL10
37
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.08 TNF IL6 IL10 IFNG
38
TNF signaling pathway 36
12.06 TNF IL6 IL1B IFNB1
39
Senescence and Autophagy in Cancer 1
12.04 IL6 IL1B IFNG IFNB1
40
NF-kappa B signaling pathway 36
12.03 TNF TLR4 LBP IL1B
41
Amoebiasis 36
11.99 TNF TLR4 TLR2 IL6 IL1B IL10
42
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.97 TLR4 LBP IL6 IL17A
43
Th17 Differentiation Pathway 64
Show member pathways
 11.97 TLR4 TLR2 IL6 IL1B IL17A IFNG
44
Rheumatoid arthritis 36
11.92 TNF TLR4 TLR2 IL6 IL1B IL17A
45
Pertussis 36
11.91 TNF TLR4 IL6 IL1B IL10
46
Innate Lymphoid Cell Differentiation Pathways 64
11.89 TNF IL1B IL17A IL10 IFNG CCR6
47
Dendritic Cells Developmental Lineage Pathway 64
11.84 TNF IL6 IL1B IL10 IFNG IFNB1
48
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.78 TNF IL6 IL1B IFNG
49
IgA-Producing B Cells in the Intestine 64
11.77 TNF TLR4 TLR2 IL6 IL10 CCR6
50
Lung fibrosis 1
11.71 TNF IL6 IL1B
Sources

GO Terms for Reactive Arthritis

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Cellular components related to Reactive Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNF PRTN3 MMP8 LTF LBP IL6
2 cell surface GO:0009986 9.76 TNF TLR4 TLR2 LTF LBP HSPD1
3 specific granule lumen GO:0035580 9.56 MMP8 LTF HP BPI
4 tertiary granule lumen GO:1904724 9.54 MMP8 LTF HP
5 extracellular space GO:0005615 9.5 TNF PRTN3 MMP8 LTF LBP IL6
6 lipopolysaccharide receptor complex GO:0046696 9.32 TLR4 HSPD1

Biological processes related to Reactive Arthritis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.29 TNF TLR4 TLR2 IL6 IL17A IL10
2 immune system process GO:0002376 10.25 TLR4 TLR2 LTF LBP IL17A HP
3 innate immune response GO:0045087 10.21 TLR4 TLR2 LBP IL17A HLA-B CRP
4 neutrophil degranulation GO:0043312 10.19 TLR2 PRTN3 MMP8 LTF HP HLA-B
5 positive regulation of gene expression GO:0010628 10.19 TNF TLR4 TLR2 MMP8 IL6 IL1B
6 inflammatory response GO:0006954 10.17 TNF TLR4 TLR2 IL6 IL1B IL17A
7 defense response to bacterium GO:0042742 10.1 TNF TLR4 LTF LBP IL10 HP
8 response to lipopolysaccharide GO:0032496 10.09 TLR4 TLR2 LBP IL1B IL10 HSPD1
9 cellular response to lipopolysaccharide GO:0071222 10.08 TNF TLR4 LBP IL6 IL1B IL10
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.08 TNF TLR4 TLR2 LTF IL6 IL1B
11 defense response GO:0006952 10.03 TNF IFNB1 HP HLA-B
12 cytokine-mediated signaling pathway GO:0019221 10.03 TNF PRTN3 LBP IL6 IL1B IL17A
13 positive regulation of DNA-binding transcription factor activity GO:0051091 10.01 TNF IL6 IL1B IL10
14 positive regulation of JNK cascade GO:0046330 9.99 TNF TLR4 MMP8 IL1B
15 negative regulation of tumor necrosis factor production GO:0032720 9.99 TLR4 LBP IL10 BPI
16 defense response to Gram-positive bacterium GO:0050830 9.99 TNF TLR2 LBP IL6 IL17A CRP
17 regulation of insulin secretion GO:0050796 9.98 TNF IL6 IL1B IFNG
18 negative regulation of interleukin-6 production GO:0032715 9.98 TNF TLR4 IL10 BPI
19 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.98 TNF TLR4 TLR2 MMP8 IL1B
20 response to glucocorticoid GO:0051384 9.96 TNF IL6 IL10 HSPD1
21 positive regulation of interferon-gamma production GO:0032729 9.96 TNF TLR4 IL1B HSPD1
22 positive regulation of interleukin-1 beta production GO:0032731 9.95 TNF TLR4 IL6 IL17A IFNG
23 positive regulation of inflammatory response GO:0050729 9.95 TNF TLR4 TLR2 IL1B IFNG HSPD1
24 acute-phase response GO:0006953 9.94 LBP IL6 HP CRP
25 positive regulation of interleukin-10 production GO:0032733 9.93 TLR4 TLR2 IL6 HSPD1
26 positive regulation of nitric oxide biosynthetic process GO:0045429 9.93 TNF TLR4 MMP8 IL1B IFNG
27 defense response to Gram-negative bacterium GO:0050829 9.93 TLR4 LTF LBP IL6 IL17A BPI
28 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 TNF IL6 IFNG
29 antimicrobial humoral response GO:0019730 9.92 PRTN3 LTF BPI
30 positive regulation of cytokine production GO:0001819 9.92 TNF IL10 IFNG
31 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.92 TNF TLR4 IL6 IL17A
32 response to activity GO:0014823 9.91 IL6 IL10 HSPD1
33 positive regulation of phagocytosis GO:0050766 9.91 TNF IL1B IFNG
34 toll-like receptor signaling pathway GO:0002224 9.9 TLR4 TLR2 LBP
35 negative regulation of viral genome replication GO:0045071 9.9 TNF LTF IFNB1
36 B cell proliferation GO:0042100 9.89 IL10 IFNB1 HSPD1
37 positive regulation of JAK-STAT cascade GO:0046427 9.89 TNF IL6 IL10
38 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.89 TLR4 TLR2 HSPD1
39 microglial cell activation GO:0001774 9.89 TNF TLR2 IFNG
40 positive regulation of interleukin-12 production GO:0032735 9.89 TLR4 TLR2 IL17A IFNG HSPD1
41 positive regulation of interleukin-8 production GO:0032757 9.88 TNF TLR4 TLR2 LBP IL6 IL1B
42 negative regulation of neurogenesis GO:0050768 9.87 TNF IL6 IL1B
43 positive regulation of osteoclast differentiation GO:0045672 9.87 TNF IL17A IFNG
44 positive regulation of macrophage activation GO:0043032 9.87 TLR4 LBP IL10 HSPD1
45 positive regulation of glial cell proliferation GO:0060252 9.86 TNF IL6 IL1B
46 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.85 TLR4 TLR2 IFNG
47 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.85 TNF IL1B IFNG
48 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.85 TNF IL1B IL10
49 humoral immune response GO:0006959 9.85 TNF LTF IL6 IFNG IFNB1 CCR6
50 positive regulation of MHC class II biosynthetic process GO:0045348 9.83 TLR4 IL10 IFNG

Molecular functions related to Reactive Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.56 PRTN3 MMP8 LTF HP
2 cytokine activity GO:0005125 9.5 TNF IL6 IL1B IL17A IL10 IFNG
3 lipopeptide binding GO:0071723 9.32 TLR2 LBP
4 lipopolysaccharide receptor activity GO:0001875 9.16 TLR4 TLR2
5 lipopolysaccharide binding GO:0001530 9.1 TLR4 TLR2 LTF LBP HSPD1 BPI
Sources

Sources for Reactive Arthritis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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