Reactive Arthritis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

PIRA MCID: RCT015 MIFTS: 55	Reactive Arthritis (PIRA) Categories: Bone diseases, Gastrointestinal diseases, Immune diseases, Infectious diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Reactive Arthritis

MalaCards integrated aliases for Reactive Arthritis:

Name: Reactive Arthritis ¹¹ ¹⁹ ⁵⁸ ⁷⁵ ¹⁴ ¹⁶

Postdysenteric Arthropathy ¹¹ ³¹

Arthritis, Reactive ⁴³ ⁷¹

Reiter Syndrome ¹⁹ ⁷¹

Reiter Disease ¹¹ ³¹

Pira ¹⁹ ⁷⁵

Post-Infectious Reactive Arthropathy ¹⁹

Fiessinger Leroy Reiter Syndrome ¹¹

Post-Dysenteric Arthropathy ⁷¹

Post-Bacterial Arthropathy ¹¹

Post-Infectious Arthritis ¹⁹

Fiessinger-Leroy Disease ⁵⁸

Polyarthritis Enterica ⁵⁸

Arthritis Urethritica ⁵⁸

Arthritis, Venereal ⁷¹

Venereal Arthritis ⁵⁸

Arthritis Reactive ⁵³

Reiter's Syndrome ¹⁹

Reiter's Disease ¹¹

Reiters Syndrome ⁵³

Characteristics:

Inheritance:

Multigenic/multifactorial ⁵⁸

Prevelance:

1-9/100000 (Worldwide) ⁵⁸

Age Of Onset:

Adolescent,Adult,Elderly ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Bone diseases Immune diseases Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³¹ ³²

Diseases of the musculoskeletal system and connective tissue

Infectious arthropathies

Reactive arthropathies

Postdysenteric arthropathy

Reiter disease

Orphanet: ⁵⁸

Rare systemic and rhumatological diseases

Sources

Summaries for Reactive Arthritis

GARD: ¹⁹ Reactive arthritis is a type of infectious arthritis that occurs as a “reaction” to an infection elsewhere in the body. This process may occur weeks or even months after the infection has resolved. In addition to joint inflammation, Reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). These symptoms may occur alone, together, or not at all. The exact cause of Reactive arthritis is unknown. It may follow an infection with Salmonella enteritidis, Salmonella typhimurium, Yersinia enterocolitica, Campylobacter jejuni, Clostridium difficile, Shigella sonnei, Entamoeba histolytica, Cryptosporidium, or Chlamydia trachomatis. Certain genes may make you more prone to the syndrome. For instance, the condition is observed more commonly in patients with human lymphocyte antigen B27 (HLA-B27) histocompatibility antigens.

MalaCards based summary: Reactive Arthritis, also known as postdysenteric arthropathy, is related to spondyloarthropathy 1 and spondylitis. An important gene associated with Reactive Arthritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Extracellular matrix organization. The drugs Azithromycin and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and skin, and related phenotypes are arthritis and joint stiffness

Orphanet: ⁵⁸ A rare spondyloarthritis characterized by acute or chronic sterile synovitis with or without extra-articular manifestations, becoming manifest after an infection.

Disease Ontology: ¹¹ An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.

Wikipedia ⁷⁵ Reactive arthritis: Reactive arthritis, also known as Reiter's syndrome, is a form of inflammatory arthritis that develops... more...

Pira: The Irish Republican Army (IRA; Irish: Óglaigh na hÉireann), also known as the Provisional Irish... more...

Sources

Related Diseases for Reactive Arthritis

Diseases related to Reactive Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 572)

#	Related Disease	Score	Top Affiliating Genes
1	spondyloarthropathy 1	32.2	TAP2 PRTN3 HSPD1 HP HLA-B CRP
2	spondylitis	31.0	TAP2 HLA-B CRP CCR6
3	tenosynovitis	30.9	PRTN3 HSPD1 CRP
4	synovitis	30.8	PRTN3 MMP8 MMP1 CRP COMP
5	spondyloarthropathy	30.8	PRTN3 HP HLA-B CRP CCR6
6	severe acute respiratory syndrome	30.7	IFNB1 CRP BSG
7	anterior uveitis	30.6	HLA-B CRP CCR6
8	tendinitis	30.6	PRTN3 CRP COMP
9	osteoarthritis	30.6	TIMP1 MMP1 CRP COMP
10	enthesopathy	30.6	HLA-B CRP CCR6
11	ornithosis	30.6	HSPD1 CRP
12	bacteremia 2	30.6	LBP CRP BPI
13	arthritis	30.6	TIMP1 MMP8 MMP1 IFNB1 HSPD1 HLA-B
14	juvenile rheumatoid arthritis	30.5	HSPD1 HP CRP CCR6
15	dysentery	30.5	LTF HP CRP CCR6
16	lyme disease	30.5	IFNB1 HSPD1 CRP
17	arthropathy	30.5	TIMP1 MMP1 CRP COMP CCR6
18	haemophilus influenzae	30.4	OMP LTF
19	exanthem	30.4	PRTN3 HLA-B CRP CCR6
20	toxic shock syndrome	30.3	LBP CRP BPI
21	syphilis	30.3	PRTN3 CRP CCR6
22	cat-scratch disease	30.3	PRTN3 HSPD1 CRP
23	vasculitis	30.2	PRTN3 LTF HSPD1 HLA-B CRP BPI
24	iritis	30.2	HLA-B CRP CCR6
25	endocarditis	30.2	LBP HSPD1 CRP CEACAM8
26	psoriatic arthritis	30.2	TIMP1 MMP1 HLA-B CRP COMP CCR6
27	henoch-schoenlein purpura	30.2	PRTN3 CRP CCR6
28	proctitis	30.2	LTF CRP CCR6
29	meningitis	30.2	TIMP1 LBP HLA-B CRP
30	olecranon bursitis	30.1	HSPD1 CRP
31	autoimmune disease	30.1	PRTN3 IFNB1 HSPD1 HLA-B CRP CCR6
32	kawasaki disease	30.1	TIMP1 HSPD1 CRP
33	infective endocarditis	30.1	PRTN3 CRP CCR6
34	interstitial keratitis	30.1	PRTN3 CRP
35	takayasu arteritis	30.1	HP HLA-B CRP
36	crohn's disease	30.0	LTF HP CRP CCR6
37	sapho syndrome	30.0	CRP CCR6
38	sjogren syndrome	30.0	PRTN3 LTF CCR6
39	bronchiectasis	30.0	MMP8 CRP BPI
40	babesiosis	30.0	HSPD1 HP CRP
41	keratoconjunctivitis	30.0	MMP1 LTF BSG
42	panuveitis	30.0	HLA-B CRP CCR6
43	hypopyon	30.0	HLA-B CRP
44	mastitis	29.9	LTF LBP HP BPI
45	severe cutaneous adverse reaction	29.9	HLA-B CRP CCR6
46	bacterial vaginosis	29.9	MMP8 LTF CCR6
47	relapsing polychondritis	29.9	PRTN3 CRP COMP
48	bacterial meningitis	29.9	TIMP1 MMP8 CRP
49	aortitis	29.9	PRTN3 CRP CCR6
50	hyperthyroidism	29.9	TRH PRTN3 CRP

Graphical network of the top 20 diseases related to Reactive Arthritis:

Sources

Symptoms & Phenotypes for Reactive Arthritis

Human phenotypes related to Reactive Arthritis:

⁵⁸ ³⁰ (show all 27)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	arthritis ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001369
2	joint stiffness ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001387
3	cognitive impairment ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0100543
4	hyperkeratosis ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0000962
5	arthralgia ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002829
6	joint swelling ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001386
7	conjunctivitis ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0000509
8	osteomyelitis ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002754
9	cartilage destruction ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0100773
10	dystrophic fingernails ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0008391
11	diarrhea ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002014
12	pustule ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0200039
13	recurrent aphthous stomatitis ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0011107
14	enthesitis ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0100686
15	inflammation of the large intestine ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002037
16	abdominal pain ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002027
17	abnormal pleura morphology ³⁰	Frequent (33%)		HP:0002103
18	respiratory insufficiency ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002093
19	photophobia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000613
20	fever ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001945
21	recurrent urinary tract infections ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000010
22	pericarditis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001701
23	weight loss ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001824
24	aortic regurgitation ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001659
25	pulmonary fibrosis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002206
26	abnormality of the nail ⁵⁸		Very frequent (99-80%)
27	abnormality of the pleura ⁵⁸		Frequent (79-30%)

MGI Mouse Phenotypes related to Reactive Arthritis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10	BSG CCR6 CEACAM8 COMP CRP HP
2	immune system	MP:0005387	9.83	ADGRE5 BSG CCR6 COMP CRP HLA-B
3	hematopoietic system	MP:0005397	9.4	ADGRE5 BSG CCR6 HLA-B HP HSPD1

Sources

Drugs & Therapeutics for Reactive Arthritis

Drugs for Reactive Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Azithromycin

Approved

Phase 3

83905-01-5

447043

Rifampicin

Approved

Phase 3

13292-46-1

135512673 5381226 135900090

Doxycycline

Approved, Investigational, Vet_approved

Phase 3

564-25-0

54671203

Anti-Bacterial Agents

Phase 3

Anti-Infective Agents

Phase 3

Antibiotics, Antitubercular

Phase 3

Antiprotozoal Agents

Phase 3

Antiparasitic Agents

Phase 3

Antimalarials

Phase 3

Antitubercular Agents

Phase 3

Infliximab

Approved

Phase 2

170277-31-3

Licorice

Approved

Phase 1, Phase 2

Turmeric

Approved, Experimental, Investigational

Phase 1, Phase 2

Glycerin

Approved, Investigational

Phase 2

56-81-5

753

Gastrointestinal Agents

Phase 2

Antiviral Agents

Phase 2

Antirheumatic Agents

Phase 2

interferons

Phase 2

Interferon-gamma

Phase 2

Tumor Necrosis Factor Inhibitors

Phase 2

Dermatologic Agents

Phase 2

Astragalus

Phase 1, Phase 2

Skullcap

Phase 1, Phase 2

Turmeric extract

Phase 1, Phase 2

Hawthorn

Phase 1, Phase 2

Chinese Yam

Phase 1, Phase 2

Chinese Salvia

Phase 1, Phase 2

Chinese Rhubarb

Phase 1, Phase 2

Vaccines

Phase 1

Rifaximin

Approved, Investigational

80621-81-4

46783403 6436173

Levofloxacin

Approved, Investigational

100986-85-4

149096

Ofloxacin

Approved

82419-36-1

4583

Roxithromycin

Approved, Investigational, Withdrawn

80214-83-1

6915744

Leflunomide

Approved, Investigational

75706-12-6

3899

Azathioprine

Approved

446-86-6

2265

Methotrexate

Approved

1959-05-2, 59-05-2

4112 126941

Mycophenolic acid

Approved, Investigational

24280-93-1

446541

Sulfasalazine

Approved

599-79-1

5353980 5339 5359476

Cytochrome P-450 Enzyme Inhibitors

Immune Checkpoint Inhibitors

Salicylates

Anesthetics

Interventional clinical trials:

(show all 16)

#	Name	Status	NCT ID	Phase	Drugs
1	Phase 3 Trial to Assess the Efficacy of Long-term (6 Months) Combination Antibiotics as a Treatment for Chlamydia-induced Reactive Arthritis	Completed	NCT00351273	Phase 3	Doxycycline and Rifampin;Azithromycin and Rifampin;Placebo
2	New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis: Immunostimulation Plus Antibiotic Versus Immunosuppression Plus Antibiotic Versus Conventional Standardtherapy	Unknown status	NCT00244179	Phase 2	interferon-gamma;infliximab;dmard
3	Treating Sequalae Caused by Post-acute Sequelae of SARS (Severe Acute Respiratory Syndrome)-CoV-2 Infection	Recruiting	NCT04846010	Phase 1, Phase 2
4	Safety and Clinical Efficacy Associated With Faecal Microbiota Transplantation Performed in Treatment-naïve Patients With Newly Diagnosed Rheumatoid Arthritis, Reactive Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Gouty Arthritis, Psoriasis, Hidradenitis Suppurativa, Pulmonary Sarcoidosis, Crohn's Disease, and Ulcerative Colitis: a 52-week, Double-blind, Randomised, Placebo-controlled, Exploratory Trial	Not yet recruiting	NCT04924270	Phase 2
5	Phase 1 Two Stage Randomized, Double-blind, Placebo Controlled Dose- and Schedule Ranging Trial to Assess the Acute Safety, Tolerability, and Immunogenicity of a Live, Attenuated Shigella/ETEC Combination Vaccine Delivered Orally to Healthy Adults Age 18 to 45 Years Old	Completed	NCT05409196	Phase 1	Placebo
6	A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial Evaluating Two Dose Regimens of Rifaximin (550 mg Daily or 550 mg Twice Daily) for Chemoprophylaxis Against Travelers' Diarrhea (TD) Among Active Duty Deployed U.S. and British Military Personnel	Unknown status	NCT02498301		Rifaximin;Placebo
7	Double-Blind, Placebo-Controlled Study of Three-Month Treatment With the Combination of Ofloxacin and Roxithromycin in Recent-Onset Reactive Arthritis	Completed	NCT00621387		ofloxacin and roxithromycin;placebo
8	Barriers and Facilitators of Flu, Pneumonia and SARS-CoV-2 (COVID-19) Vaccination in Adults With Inflammatory Conditions Treated With Immune-suppressing Drugs	Completed	NCT05115370
9	Late Cardial Assessment in Children Who Were Diagnosed With Post Streptococcal Reactive Arthritis - a Long Term Study	Completed	NCT01179451
10	A Bicentre Retrospective Study of Features and Outcomes of Patients With Reactive Arthritis	Completed	NCT03926429
11	Prognostic Indicators and Determinants of the 2-5 Year Outcome in a Cohort of Early Synovitis Patients	Completed	NCT00001679
12	The Pathogenesis of Inflammatory Synovitis: A Study of Early Arthritis	Completed	NCT00001375
13	Testing of an Educational Tool for Patients With Melanoma and Concomitant Autoimmune Disease Who Are Candidates for Adjuvant Therapy With Immune Checkpoint Inhibitors: Acceptability and Usability With Patients and Providers	Recruiting	NCT04751396
14	Rheumatology Patient Registry and Biorepository	Recruiting	NCT04402086
15	Exploring Patient and Healthcare Professional Views and Experiences of the Current and Recommended Monitoring Strategies for Inflammatory Conditions Treated With Commonly Used Immune Suppressing Drugs	Recruiting	NCT05458531
16	A Pilot Randomized Control Trial Testing the Acceptability and Feasibility of a Pediatric Interactive Relational Agent (PIRA) vs. Standard Preoperative Education	Recruiting	NCT04586569

Search NIH Clinical Center for Reactive Arthritis

Cochrane evidence based reviews: arthritis, reactive

Sources

Genetic Tests for Reactive Arthritis

Sources

Anatomical Context for Reactive Arthritis

Organs/tissues related to Reactive Arthritis:

MalaCards : Bone, T Cells, Skin, Monocytes, Eye, Heart, Neutrophil

Sources

Publications for Reactive Arthritis

Articles related to Reactive Arthritis:

(show top 50) (show all 4703)

#	Title	Authors	PMID	Year
1	Evaluation of the appropriateness of composite disease activity measures for assessment of psoriatic arthritis. ⁵³ ⁶²	Nell-Duxneuner VP...Smolen JS	19762363	2010
2	[Some proteins of acute phase of inflammation in differential diagnostics of rheumatoid arthritis]. ⁵³ ⁶²	Zorina VN...Zorin NA	18720714	2008
3	Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage damage and/or the therapeutic efficacy of treatments. ⁵³ ⁶²	Morozzi G...Galeazzi M	17894003	2007
4	Serum levels of cartilage oligomeric matrix protein (COMP): a rapid decrease in patients with active rheumatoid arthritis undergoing intravenous steroid treatment. ⁵³ ⁶²	Skoumal M...Dunky A	16485108	2006
5	Undifferentiated spondyloarthropathy in Chinese patients. ⁵³ ⁶²	Liao HT...Chou CT	16513489	2006
6	Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis. ⁵³ ⁶²	van Holten J...Tak PP	15878901	2005
7	Serum levels of cartilage oligomeric matrix protein are elevated in rheumatoid arthritis, but not in inflammatory rheumatic diseases such as psoriatic arthritis, reactive arthritis, Raynaud's syndrome, scleroderma, systemic lupus erythematosus, vasculitis and Sjögren's syndrome. ⁵³ ⁶²	Skoumal M...Dunky A	15059267	2004
8	Importance of species-specific antigens in the serodiagnosis of Chlamydia trachomatis reactive arthritis. ⁵³ ⁶²	Bas S...Vischer TL	12209035	2002
9	IgM, IgG, and IgA response to enterobacteria in patients with ankylosing spondylitis in southern India. ⁵³ ⁶²	Madhavan R...Alamelu R	12021151	2002
10	Multispecific CD4+ T cell response to a single 12-mer epitope of the immunodominant heat-shock protein 60 of Yersinia enterocolitica in Yersinia-triggered reactive arthritis: overlap with the B27-restricted CD8 epitope, functional properties, and epitope presentation by multiple DR alleles. ⁵³ ⁶²	Mertz AK...Sieper J	10640771	2000
11	BPI-ANCA is found in reactive arthritis caused by Yersinia and Salmonella infection and recognise exclusively the C-terminal part of the BPI molecule. ⁵³ ⁶²	Schultz H...Gross WL	11028843	2000
12	Anti-lactoferrin antibodies and other types of anti-neutrophil cytoplasmic antibodies (ANCA) in reactive arthritis and ankylosing spondylitis. ⁵³ ⁶²	Locht H...Kihlstrom E	10469064	1999
13	Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue. ⁵³ ⁶²	Hamann J...Tak PP	10211878	1999
14	TAP2 alleles in inflammatory arthritis. ⁵³ ⁶²	Tuokko J...Ilonen J	9645419	1998
15	Identification and characterization of a DR4-restricted T cell epitope within chlamydia heat shock protein 60. ⁵³ ⁶²	Deane KH...Gaston JS	9328119	1997
16	Antigen-dependent B cell differentiation in the synovial tissue of a patient with reactive arthritis. ⁵³ ⁶²	Schroder AE...Berek C	9131588	1997
17	Prediction of diagnosis in acute and subacute oligoarthritis of unknown origin. ⁵³ ⁶²	Kvien TK...Melby K	8624640	1996
18	Autoantibodies to human heat shock protein (hsp)60 may be induced by Escherichia coli groEL. ⁵³ ⁶²	Handley HH...Vaughan JH	8608642	1996
19	[Blood prolactin under the effect of protirelin in spondylarthropathies. Treatment trial of 4 cases of reactive arthritis and 2 cases of psoriatic arthritis with bromocriptine]. ⁵³ ⁶²	Eulry F...Claude-Berthelot C	8763085	1996
20	TAP1 and TAP2 polymorphism in HLA-B27-positive subpopulations: no allelic differences in ankylosing spondylitis and reactive arthritis. ⁵³ ⁶²	Westman P...Koskimies S	8770637	1995
21	Oncogene expression in synovial fluid cells in reactive and early rheumatoid arthritis: a brief report. ⁵³ ⁶²	Roivainen A...Toivanen P	7582717	1995
22	Lipopolysaccharide binding protein as a marker of inflammation in synovial fluid of patients with arthritis: correlation with interleukin 6 and C-reactive protein. ⁵³ ⁶²	Heumann D...Vischer T	7562749	1995
23	[Prolactin response to protirelin in reactive arthritis and ankylosing spondyloarthritis. Failure of treatment of 4 reactive arthritis with bromocriptine]. ⁵³ ⁶²	Eulry F...Lechevalier D	7858584	1994
24	In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis. ⁵³ ⁶²	Lauhio A...Sorsa T	7923879	1994
25	[Relative hyperprolactinemia under protirelin in reactive arthritis. Preliminary results]. ⁵³ ⁶²	Eulry F...Magnin J	7971809	1994
26	Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis. ⁵³ ⁶²	Lauhio A...Sorsa T	8192476	1994
27	Serum antibodies from patients with ankylosing spondylitis and Reiter's syndrome are reactive with HLA-B27 cells transfected with the Mycobacterium tuberculosis hsp60 gene. ⁵³ ⁶²	Kellner H...Yu DT	7905462	1994
28	Responses to gram negative enteric bacterial antigens by synovial T cells from patients with juvenile chronic arthritis: recognition of heat shock protein HSP60. ⁵³ ⁶²	Life P...Gaston JS	7693941	1993
29	Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. ⁵³ ⁶²	Kasinrerk W...Stockinger H	1634773	1992
30	IgG and IgA antibody responses against porins in Yersinia-triggered reactive arthritis. ⁵³ ⁶²	Maki-Ikola O...Granfors K	1316199	1992
31	Cytidine deaminase and lactoferrin in inflammatory synovial fluids. Indicators of local polymorphonuclear cell function? ⁵³ ⁶²	Geborek P...Saxne T	1555038	1992
32	Does reduced erythrocyte C3b receptor (CR1) activity contribute to the pathogenesis of yersinia triggered reactive arthritis? ⁵³ ⁶²	Lahesmaa R...Toivanen A	1531747	1992
33	Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis, and systemic lupus erythematosus. ⁵³ ⁶²	Metsarinne KP...Fyhrquist FY	1384103	1992
34	Salmonella-specific antibodies in reactive arthritis. ⁵³ ⁶²	Maki-Ikola O...Granfors K	1955713	1991
35	Analysis of function-associated receptor molecules on peripheral blood and synovial fluid granulocytes from patients with rheumatoid and reactive arthritis. ⁵³ ⁶²	Felzmann T...Knapp W	1918267	1991
36	[A comparative study of serum complement (C3 and C4) in inflammatory joint diseases]. ⁵³ ⁶²	Dacheva V...Koleva P	1706901	1990
37	Evaluation of clinical and paraclinical findings in patients with reactive arthritis caused by giardiasis: A systematic review. ⁶²	Mahdavi J...Ghasemikhah R	36174478	2022
38	Cutaneous and rheumatological manifestations of reactive arthritis: A case report. ⁶²	Slouma M...Louzir B	36381024	2022
39	Poncet's Disease (Reactive Arthritis Associated with Tuberculosis). ⁶²	Higashiguchi M...Komuta K	35342140	2022
40	Schistosomiasis and Recurrent Arthritis: A Systematic Review of the Literature. ⁶²	Mortier C...L'Ollivier C	36422620	2022
41	Back-to-back: The co-occurrence of DISH and ankylosing spondylitis from early modern Poland. ⁶²	Betsinger TK...Scott AB	36375277	2022
42	Serologic Biomarkers of Progression Toward Diagnosis of Rheumatoid Arthritis in Active Component Military Personnel. ⁶²	Loza MJ...Porter CK	35671369	2022
43	Revisiting the antiviral theory to explain interferon-beta's effectiveness for relapsing multiple sclerosis. ⁶²	Sedaghat N...Etemadifar M	36116383	2022
44	Fabrication of lateral flow immunoassay strip for rapid detection of acute hepatopancreatic necrosis disease. ⁶²	Duong ND...Tran-Van H	36033912	2022
45	Purification, characterization and toxicity assessment of PirAB toxins from Photorhabdus akhurstii subsp. akhurstii K-1. ⁶²	Prashar A...Hire RS	36167186	2022
46	Post-streptococcal Reactive Arthritis Visually Emphasizing Enthesitis. ⁶²	Tatsumi H...Suyama Y	36261371	2022
47	Arthritis after SARS-CoV-2 infection: reactive arthritis or virally mediated arthritis? ⁶²	Baimukhamedov C...Botabekova A	36210396	2022
48	[Reactive arthritis with SARS-COV-2 as a trigger]. ⁶²	Ruiz-Del-Valle V...Lobato-Cano R	35079258	2022
49	[History of reactive arthritis. Historical milestones and future]. ⁶²	Zeidler H	36006472	2022
50	Reactive arthritis with SARS-COV-2 as a trigger. ⁶²	Ruiz-Del-Valle V...Lobato-Cano R	35562296	2022

Sources

Genes for Reactive Arthritis

Genes related to Reactive Arthritis (1 elite genes):

(show all 25)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	52.5	Orphanet ⁵⁸ DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	9131588
2	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	26.97	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7905462 8608642 9328119 (more) 10640771 7693941
3	PRTN3	Proteinase 3	Protein Coding	16.57	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10469064
4	BPI	Bactericidal Permeability Increasing Protein	Protein Coding	16.34	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11028843
5	HP	Haptoglobin	Protein Coding	14.97	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1706901
6	MMP8	Matrix Metallopeptidase 8	Protein Coding	14.19	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7923879 8192476
7	LTF	Lactotransferrin	Protein Coding	13.94	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1555038 7923879 10469064 (more) 18720714
8	CRP	C-Reactive Protein	Protein Coding	13.36	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16485108 7562749 1384103 (more) 19762363 8624640 16513489
9	LBP	Lipopolysaccharide Binding Protein	Protein Coding	13.34	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7562749
10	IFNB1	Interferon Beta 1	Protein Coding	13.04	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15878901
11	OMP	Olfactory Marker Protein	Protein Coding	12.49	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12021151
12	TRH	Thyrotropin Releasing Hormone	Protein Coding	11.73	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7858584 8763085 7971809
13	COMP	Cartilage Oligomeric Matrix Protein	Protein Coding	11.7	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16485108 15059267 17894003
14	MMP1	Matrix Metallopeptidase 1	Protein Coding	10.97	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
15	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	10.46	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
16	TAP2	Transporter 2, ATP Binding Cassette Subfamily B Member	Protein Coding	10.45	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8770637 9645419
17	ADGRE5	Adhesion G Protein-Coupled Receptor E5	Protein Coding	10.13	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	10211878
18	BSG	Basigin (Ok Blood Group)	Protein Coding	9.95	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1634773 1918267
19	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	9.64	DISEASES inferred ¹⁴ ¹⁴
20	CEACAM8	CEA Cell Adhesion Molecule 8	Protein Coding	9.54	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
21	CD79A	CD79a Molecule	Protein Coding	8.93	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1316199 1955713 12021151 (more) 12209035 16513489
22	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	7.21	DISEASES inferred ¹⁴
23	TNF	Tumor Necrosis Factor	Protein Coding	6.94	DISEASES inferred ¹⁴
24	IL17A	Interleukin 17A	Protein Coding	6.83	DISEASES inferred ¹⁴
25	ERAP1	Endoplasmic Reticulum Aminopeptidase 1	Protein Coding	6.8	DISEASES inferred ¹⁴

Sources

Variations for Reactive Arthritis

Sources

Expression for Reactive Arthritis

Search GEO for disease gene expression data for Reactive Arthritis.

Sources

Pathways for Reactive Arthritis

Pathways related to Reactive Arthritis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.05	TIMP1 TAP2 PRTN3 MMP8 MMP1 LTF
2	Extracellular matrix organization ⁶⁶ Show member pathways Degradation of the extracellular matrix ⁶⁶	12.08	TIMP1 MMP8 MMP1 COMP CEACAM8 BSG
3	Defensins ⁶⁶ Show member pathways Alpha-defensins ⁶⁶ Antimicrobial peptides ⁶⁶ Beta defensins ⁶⁶ Ion influx/efflux at host-pathogen interface ⁶⁶ Metal sequestration by antimicrobial proteins ⁶⁶	11.98	PRTN3 LTF CCR6 BPI
4	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.67	TIMP1 MMP1 LBP
5	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.5	LBP IFNB1 CRP
6	Burn wound healing ⁷⁴	11.46	TIMP1 MMP1 IFNB1
7	Matrix metalloproteinases ⁷⁴ Show member pathways Activation of Matrix Metalloproteinases ⁶⁶ Inhibition of Matrix Metalloproteinases ⁶⁴	11.46	BSG MMP1 MMP8 TIMP1
8	IL6-mediated signaling events ⁶¹	11.15	TIMP1 LBP CRP
9	Development_Leptin signaling via JAK/STAT and MAPK cascades ²² Show member pathways phospho-PLA2 pathway ⁶⁶	10.91	TRH TIMP1 CRP

Sources

GO Terms for Reactive Arthritis

Cellular components related to Reactive Arthritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	10.34	ADGRE5 BPI BSG CEACAM8 COMP HLA-B
2	extracellular region	GO:0005576	10.05	ADGRE5 BPI COMP CRP HP IFNB1
3	tertiary granule lumen	GO:1904724	9.85	MMP8 LTF HP
4	specific granule lumen	GO:0035580	9.76	MMP8 LTF HP BPI
5	extracellular space	GO:0005615	9.72	TIMP1 PRTN3 MMP8 LTF LBP IFNB1
6	sperm plasma membrane	GO:0097524	9.62	HSPD1 CCR6

Biological processes related to Reactive Arthritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of chondrocyte proliferation	GO:1902732	9.56	LTF COMP
2	opsonization	GO:0008228	9.46	LBP CRP
3	collagen catabolic process	GO:0030574	9.43	PRTN3 MMP8 MMP1
4	acute-phase response	GO:0006953	9.1	LBP HP CRP