MCID: RCT015
MIFTS: 63

Reactive Arthritis

Categories: Rare diseases, Bone diseases, Gastrointestinal diseases

Aliases & Classifications for Reactive Arthritis

MalaCards integrated aliases for Reactive Arthritis:

Name: Reactive Arthritis 12 76 53 59 15
Reiter Syndrome 53 59 73
Arthritis, Reactive 44 73
Reiter Disease 12 59
Post-Infectious Reactive Arthropathy 53
Fiessinger Leroy Reiter Syndrome 12
Fiessinger-Leroy-Reiter Syndrome 59
Post-Dysenteric Arthropathy 73
Post-Bacterial Arthropathy 12
Postdysenteric Arthropathy 12
Post-Infectious Arthritis 53
Fiessinger-Leroy Disease 59
Polyarthritis Enterica 59
Arthritis Urethritica 59
Arthritis, Venereal 73
Venereal Arthritis 59
Arthritis Reactive 55
Reiter's Syndrome 53
Reiter's Disease 12
Reiters Syndrome 55
Pira 53

Characteristics:

Orphanet epidemiological data:

59
reactive arthritis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



Summaries for Reactive Arthritis

NIH Rare Diseases : 53 Reactive arthritis is a type of infectious arthritis that occurs as a “reaction” to an infection elsewhere in the body. This process may occur weeks or even months after the infection has resolved. In addition to joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). These symptoms may occur alone, together, or not at all. The symptoms of reactive arthritis usually last 3 to 12 months, although symptoms can return or develop into a long-term disease in a small percentage of people. The exact cause of reactive arthritis is unknown. It may follow an infection with Salmonella enteritidis, Salmonella typhimurium, Yersinia enterocolitica, Campylobacter jejuni, Clostridium difficile, Shigella sonnei, Entamoeba histolytica, Cryptosporidium, or Chlamydia trachomatis. Certain genes may make you more prone to the syndrome. For instance, the condition is observed more commonly in patients with human lymphocyte antigen B27 (HLA-B27) histocompatibility antigens. The goal of treatment is to relieve symptoms and treat any underlying infection. Antibiotics may be prescribed. Nonsteroidal anti-inflammatory drugs (NSAIDS), pain relievers, and corticosteroids may be recommended for those with joint pain. 

MalaCards based summary : Reactive Arthritis, also known as reiter syndrome, is related to spondyloarthropathy 1 and arthritis. An important gene associated with Reactive Arthritis is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Doxycycline and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and bone, and related phenotypes are recurrent urinary tract infections and conjunctivitis

Disease Ontology : 12 An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.

Wikipedia : 76 Reactive arthritis, formerly known as Reiter\'s syndrome, is a form of inflammatory arthritis that... more...

Related Diseases for Reactive Arthritis

Diseases related to Reactive Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 356)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 1 31.5 CD79A CRP HLA-B TNF
2 arthritis 30.9 IFNG IL10 IL6 TNF
3 anterior uveitis 30.4 HLA-B IL6
4 cat-scratch disease 30.4 HSPD1 IFNG
5 streptococcal toxic-shock syndrome 30.2 IL6 TNF
6 urethritis 29.9 CD79A HSPD1
7 osteomyelitis 29.8 IFNG IL6 TNF
8 uveitis 29.6 HLA-B IFNG IL10 TNF
9 strongyloidiasis 29.6 CD79A IFNG
10 colitis 29.5 IFNG IL10 IL6 TNF
11 osteoarthritis 29.5 COMP IL6 TNF
12 rheumatic heart disease 29.4 IL10 IL6 TNF
13 prostatitis 29.4 IL10 IL6 TNF
14 spondylitis 29.4 CRP HLA-B IL6 TNF
15 spondyloarthropathy 29.4 HLA-B IFNG IL10 IL6 TNF
16 tetanus 29.4 CD79A IFNG IL10
17 tonsillitis 29.2 CD79A IFNG IL6 TNF
18 erythema multiforme 29.2 CD79A IFNG TNF
19 toxic shock syndrome 29.0 IFNG IL10 IL6 TNF
20 juvenile rheumatoid arthritis 28.8 CRP IL6 TNF
21 psoriasis 28.7 IFNG IL10 IL6 TNF
22 pneumonia 28.6 CRP IL10 IL6 TNF
23 arthropathy 28.5 COMP CRP TNF
24 otitis media 28.4 CD79A IL10 IL6 TNF
25 synovitis 28.2 COMP CRP IL6 TNF
26 gastroenteritis 28.1 CRP IFNG IL10 IL6 TNF
27 psoriatic arthritis 28.1 COMP CRP HLA-B IL6 TNF
28 vasculitis 28.0 BPI CD79A CRP TNF
29 ulcerative colitis 28.0 CRP IL10 IL6 TNF
30 rheumatic disease 27.5 CRP HLA-B IFNG IL10 TNF
31 brucellosis 27.5 CRP IFNG IL10 IL6 TNF
32 appendicitis 27.4 CRP IL10 IL6 MMP8 TNF
33 bacterial meningitis 27.4 CRP IL10 IL6 MMP8 TNF
34 chlamydia 27.2 CD79A CRP HSPD1 IFNG IL10 IL6
35 meningitis 26.8 CRP IFNG IL10 IL6 OMP TNF
36 inflammatory bowel disease 26.7 BPI CRP HLA-B IFNG IL10 IL6
37 systemic lupus erythematosus 26.6 CD79A CRP IFNG IL10 IL6 TNF
38 rheumatoid arthritis 26.0 CD79A COMP CRP HLA-B IFNG IL10
39 septic arthritis 11.6
40 shigellosis 11.3
41 b-cell growth factor 10.8 IFNG IL6
42 far eastern spotted fever 10.8 HSPD1 IFNG
43 periodontitis, chronic 10.7 IL6 MMP8
44 scorpion envenomation 10.7 IL6 TNF
45 leukomalacia 10.7 IL6 TNF
46 angioimmunoblastic lymphadenopathy with dysproteinemia 10.7 IL6 TNF
47 staphylococcal toxic shock syndrome 10.6 IFNG TNF
48 critical limb ischemia 10.6 IL6 TNF
49 autoimmune myocarditis 10.6 IFNG TNF
50 null-cell leukemia 10.6 IL6 TNF

Graphical network of the top 20 diseases related to Reactive Arthritis:



Diseases related to Reactive Arthritis

Symptoms & Phenotypes for Reactive Arthritis

Human phenotypes related to Reactive Arthritis:

59 32 (show all 26)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 recurrent urinary tract infections 59 32 occasional (7.5%) Occasional (29-5%) HP:0000010
2 conjunctivitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000509
3 photophobia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000613
4 hyperkeratosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000962
5 arthritis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001369
6 joint swelling 59 32 hallmark (90%) Very frequent (99-80%) HP:0001386
7 joint stiffness 59 32 hallmark (90%) Very frequent (99-80%) HP:0001387
8 aortic regurgitation 59 32 occasional (7.5%) Occasional (29-5%) HP:0001659
9 pericarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001701
10 weight loss 59 32 occasional (7.5%) Occasional (29-5%) HP:0001824
11 fever 59 32 occasional (7.5%) Occasional (29-5%) HP:0001945
12 diarrhea 59 32 hallmark (90%) Very frequent (99-80%) HP:0002014
13 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
14 inflammation of the large intestine 59 32 frequent (33%) Frequent (79-30%) HP:0002037
15 respiratory insufficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0002093
16 abnormality of the pleura 59 32 frequent (33%) Frequent (79-30%) HP:0002103
17 pulmonary fibrosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002206
18 osteomyelitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002754
19 arthralgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002829
20 dystrophic fingernails 59 32 hallmark (90%) Very frequent (99-80%) HP:0008391
21 recurrent aphthous stomatitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0011107
22 cognitive impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0100543
23 enthesitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100686
24 cartilage destruction 59 32 hallmark (90%) Very frequent (99-80%) HP:0100773
25 pustule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200039
26 abnormality of the nail 59 Very frequent (99-80%)

MGI Mouse Phenotypes related to Reactive Arthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 TNF TRH CD79A COMP CRP IFNG
2 muscle MP:0005369 9.63 TNF COMP HSPD1 IFNG IL10 IL6
3 neoplasm MP:0002006 9.43 TNF CD79A IFNG IL10 IL6 MMP8
4 no phenotypic analysis MP:0003012 9.1 TNF TRH CD79A IFNG IL10 OMP

Drugs & Therapeutics for Reactive Arthritis

Drugs for Reactive Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
2
Rifampicin Approved Phase 3 13292-46-1 5458213 5381226
3
Azithromycin Approved Phase 3 83905-01-5 55185 447043
4 Anti-Bacterial Agents Phase 3,Phase 2,Not Applicable
5 Antibiotics, Antitubercular Phase 3,Phase 2,Not Applicable
6 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
7 Cytochrome P-450 CYP3A Inducers Phase 3
8 Nucleic Acid Synthesis Inhibitors Phase 3,Not Applicable
9 Antiparasitic Agents Phase 3
10 Antiprotozoal Agents Phase 3
11 Antitubercular Agents Phase 3
12 Antimalarials Phase 3
13
Infliximab Approved Phase 2 170277-31-3
14 interferons Phase 2
15 Gastrointestinal Agents Phase 2,Not Applicable
16 Dermatologic Agents Phase 2
17 Interferon-gamma Phase 2
18 Antirheumatic Agents Phase 2
19 Antiviral Agents Phase 2
20 Vaccines Phase 2,Phase 1,Not Applicable
21
Ofloxacin Approved Not Applicable 82419-36-1 4583
22
Etanercept Approved, Investigational 185243-69-0
23
Adalimumab Approved 331731-18-1 16219006
24
Levofloxacin Approved, Investigational Not Applicable 100986-85-4 149096
25
Rifaximin Approved, Investigational Not Applicable 80621-81-4 6436173
26 Renal Agents Not Applicable
27 Cytochrome P-450 CYP1A2 Inhibitors Not Applicable
28 Cytochrome P-450 Enzyme Inhibitors Not Applicable
29 Topoisomerase Inhibitors Not Applicable
30 Anti-Inflammatory Agents
31 Anti-Inflammatory Agents, Non-Steroidal
32 rifamycin SV Not Applicable
33 Rifamycins Not Applicable
34 Cola Nutraceutical

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria Completed NCT00351273 Phase 3 Doxycycline and Rifampin;Azithromycin and Rifampin;Placebo
2 Mechanism of Action of Anti-IL17 Therapy in Peripheral Spondyloarthritis Completed NCT03358134 Phase 3 Secukinumab
3 New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis Unknown status NCT00244179 Phase 2 interferon-gamma;infliximab;dmard
4 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
5 Safety Study of Inactivated Shigella Whole Cell Vaccine in Adults Completed NCT01509846 Phase 1
6 Study of Long-Term Antibiotic Treatment in Reactive Arthritis Completed NCT00621387 Not Applicable ofloxacin and roxithromycin;placebo
7 Late Cardial Assessment in Children Who Were Diagnosed With Post Streptococcal Reactive Arthritis - a Long Term Study Completed NCT01179451
8 Longitudinal ULtrasonographic Study of Patients With Spondylarthritis Starting Biological Therapy Completed NCT01219257
9 The Pathogenesis of Inflammatory Synovitis: A Study of Early Arthritis Completed NCT00001375
10 The Characterization of Small Bowel and Colonic Involvement in Patients With Seronegative Spondyloarthritides Completed NCT00768950
11 Safety Study of Live Shigella Vaccine in Bangladeshi Adults and Children Completed NCT01813071 Not Applicable
12 Prognostic Indicators and Determinants of the 2-5 Year Outcome in a Cohort of Early Synovitis Patients Completed NCT00001679
13 Diagnostic Value of DECT Scan Compared to Diagnostic Needle Aspiration Recruiting NCT03038386 Not Applicable
14 Trial Evaluating Chemoprophylaxis Against Travelers' Diarrhea - Prevent TD Active, not recruiting NCT02498301 Not Applicable Rifaximin;Placebo
15 Rheumatological Manifestations in Inflammatory Bowel Diseases Not yet recruiting NCT03486652

Search NIH Clinical Center for Reactive Arthritis

Cochrane evidence based reviews: arthritis, reactive

Genetic Tests for Reactive Arthritis

Anatomical Context for Reactive Arthritis

MalaCards organs/tissues related to Reactive Arthritis:

41
Eye, T Cells, Bone, Colon, B Cells, Tonsil, Neutrophil

Publications for Reactive Arthritis

Articles related to Reactive Arthritis:

(show top 50) (show all 595)
# Title Authors Year
1
Chronic reactive arthritis associated with prostatitis caused by<i>Neisseria meningitidis</i>. ( 29374652 )
2018
2
Hypertrophic osteoarthropathy mimicking a reactive arthritis: a case report and review of the literature. ( 29759083 )
2018
3
<i>Clostridium difficile</i> Colitis Leading to Reactive Arthritis: A Rare Complication Associated With a Common Disease. ( 29623279 )
2018
4
Disease-association of different killer cell immunoglobulin-like receptors (KIR) and HLA-C gene combinations in reactive arthritis. ( 29848119 )
2018
5
Reactive arthritis: update 2018. ( 29455267 )
2018
6
Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis. ( 29073348 )
2018
7
Potential risk factors for reactive arthritis and persistence of symptoms at 2A years: a case-control study with longitudinal follow-up. ( 29139030 )
2018
8
Poststreptococcal reactive arthritis in Japan. ( 29606414 )
2018
9
IL-12/23p40 overproduction by dendritic cells leads to an increased Th1 and Th17 polarization in a model of Yersinia enterocolitica-induced reactive arthritis in TNFRp55-/- mice. ( 29494692 )
2018
10
Metabolite assignment of ultrafiltered synovial fluid extracted from knee joints of reactive arthritis patients using high resolution NMR spectroscopy. ( 29907975 )
2018
11
Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing I^I'T Cells. ( 28944217 )
2017
12
Human Leukocyte Antigen-B27: The Genetic Predisposition Leading to Reactive Arthritis during Induction Phase Chemotherapy for Acute Myeloid Leukemia. ( 29200696 )
2017
13
Yersinia enterocolitica biotype 1A: a possible new trigger of reactive arthritis. ( 28918489 )
2017
14
HLA-B27 Correlates with the Intracellular Elimination, Replication, and Trafficking of Salmonella Enteritidis Collected from Reactive Arthritis Patients. ( 29135969 )
2017
15
The Case of Reactive Arthritis Secondary to Echinococcus Infestation. ( 28607793 )
2017
16
Strongly positive anti-CCP antibodies in patients with sacroiliitis or reactive arthritis post-E.A coli infection: A mini case-series based review. ( 28589668 )
2017
17
A retrospective study: Acute rheumatic fever and post-streptococcal reactive arthritis in Japan. ( 28442182 )
2017
18
Reactive Arthritis. ( 28292540 )
2017
19
Reactive Arthritis Caused by Yersinia enterocolitica Enteritis. ( 28502944 )
2017
20
A case of reactive arthritis secondary to sexually acquired <i>Shigella flexneri</i>. ( 29744120 )
2017
21
Chlamydia trachomatis-induced reactive arthritis in India: frequency and clinical presentation. ( 28576785 )
2017
22
Epidemiology: Time to revisit the concept of reactive arthritis. ( 28490789 )
2017
23
Understanding TMJ reactive arthritis. ( 28760073 )
2017
24
A bicentre retrospective study of features and outcomes of patients with reactive arthritis. ( 28238883 )
2017
25
Reactive arthritis associated with<i>Strongyloides stercoralis</i>: Report of an uncommon relation. ( 29114491 )
2017
26
Streptococcal tonsillitis related reactive arthritis - clinical, ultrasound imaging and immunohistochemical study. ( 29250657 )
2017
27
Prevalence of Chlamydia-associated reactive arthritis. ( 28067600 )
2017
28
Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis. ( 28496443 )
2017
29
IL-17 and IFN-I^ producing NK and I^I'-T cells are preferentially expanded in synovial fluid of patients with reactive arthritis and undifferentiated spondyloarthritis. ( 28390966 )
2017
30
Bilateral interstitial keratitis with anterior stromal infiltrates associated with reactive arthritis. ( 28687682 )
2017
31
A Case of Reactive Arthritis Associated With Lymphogranuloma Venereum Infection in a Woman. ( 27513386 )
2016
32
Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research. ( 27681924 )
2016
33
Early treatment of reactive arthritis with etanercept and 2 years follow-up. ( 27269651 )
2016
34
Association between Giardia and arthritis or joint pain in a large health insurance cohort: could it be reactive arthritis? ( 27640995 )
2016
35
The incidence of sexually acquired reactive arthritis: a systematic literature review. ( 27480977 )
2016
36
Frequency of reactive arthritis, uveitis, and conjunctivitis in Japanese patients with bladder cancer following intravesical BCG therapy: A 20-year, two-centre retrospective study. ( 27825571 )
2016
37
Clostridium difficile Enterocolitis and Reactive Arthritis: A Case Report and Review of the Literature. ( 27190666 )
2016
38
Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis. ( 27977029 )
2016
39
Recent advances and future directions in understanding and treating Chlamydia-induced reactive arthritis. ( 27627462 )
2016
40
Reactive Arthritis Caused by Urinary Tract Infection. ( 27150879 )
2016
41
Recombinant Salmonella typhimurium Outer membrane protein A is recognized by synovial fluid CD8 cells and stimulates synovial fluid mononuclear cells to produce IL17/IL23 in patients with Reactive arthritis and undifferentiated spondyloarthropathy. ( 27060348 )
2016
42
Anti-TNF treatment of reactive arthritis. A monocentric experience. ( 27236263 )
2016
43
Reactive arthritis following a Microsporidia infection. ( 27020082 )
2016
44
Microbe-triggered arthropathies: reactive arthritis and beyond. ( 27232885 )
2016
45
A case of reactive arthritis due to Clostridium difficile colitis. ( 26908381 )
2016
46
Epidemiology of Clostridium difficile Infection-Associated Reactive Arthritis in Children: An Underdiagnosed, Potentially Morbid Condition. ( 27182697 )
2016
47
Sexually acquired reactive arthritis. ( 27037393 )
2016
48
Post-streptococcal reactive arthritis: where are we now. ( 27520996 )
2016
49
Trafficking of antigens from gut to sacroiliac joints and spine in reactive arthritis and spondyloarthropathies: Mainly through lymphatics? ( 26968111 )
2016
50
Evolution over thirty years of the profile of inpatients with reactive arthritis in a tertiary rheumatology unit. ( 27600249 )
2016

Variations for Reactive Arthritis

Expression for Reactive Arthritis

Search GEO for disease gene expression data for Reactive Arthritis.

Pathways for Reactive Arthritis

Pathways related to Reactive Arthritis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 BPI CD79A CRP HLA-B IFNG IL10
2
Show member pathways
12.69 HLA-B HSPD1 IFNG IL10 IL6 TNF
3
Show member pathways
12.47 IFNG IL10 IL6 TNF
4
Show member pathways
12.45 HLA-B IFNG IL10 IL6 TNF
5 12.44 CD79A IFNG IL10 TNF
6
Show member pathways
12.33 IFNG IL10 IL6 TNF
7
Show member pathways
12.31 IFNG IL10 IL6 TNF
8
Show member pathways
12.22 CRP IFNG IL6 TNF
9
Show member pathways
12.13 IFNG IL10 IL6 TNF
10 12.04 HSPD1 IL10 IL6 TNF
11 11.97 HSPD1 IFNG IL10 IL6 TNF
12 11.9 IFNG IL6 TNF
13 11.88 IL10 IL6 TNF
14 11.77 IFNG IL10 IL6
15 11.75 IFNG IL6 TNF
16 11.72 IFNG IL10 IL6 TNF
17 11.7 IFNG IL10 TNF
18 11.66 IL10 IL6 TNF
19 11.62 CD79A IFNG IL10 IL6 TNF
20
Show member pathways
11.57 IFNG IL6 TNF
21 11.54 IFNG IL10 IL6 TNF
22 11.49 HSPD1 IL6 TNF
23 11.45 IFNG IL6 TNF
24 11.41 IL10 IL6 TNF
25 11.37 IFNG IL6 TNF
26 11.23 IL10 IL6 TNF
27 11.18 IFNG IL6 TNF
28 11.1 IFNG IL10 IL6 TNF
29 11 IL6 TNF
30 10.86 CRP IL6 TNF
31 10.73 IFNG IL10 IL6 TNF
32 10.71 COMP IFNG IL10 IL6 TNF

GO Terms for Reactive Arthritis

Cellular components related to Reactive Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 BPI COMP CRP IFNG IL10 IL6
2 extracellular space GO:0005615 9.28 BPI COMP CRP HSPD1 IFNG IL10

Biological processes related to Reactive Arthritis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.91 CRP IL10 IL6 TNF
2 positive regulation of gene expression GO:0010628 9.9 CRP IFNG IL6 TNF
3 regulation of signaling receptor activity GO:0010469 9.83 IFNG IL10 IL6 TNF TRH
4 cellular response to lipopolysaccharide GO:0071222 9.79 IL10 IL6 TNF
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.74 IL10 IL6 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.73 CRP IL6 TNF
7 response to glucocorticoid GO:0051384 9.7 IL10 IL6 TNF
8 humoral immune response GO:0006959 9.65 IFNG IL6 TNF
9 positive regulation of interleukin-6 production GO:0032755 9.63 HSPD1 IL6 TNF
10 positive regulation of osteoclast differentiation GO:0045672 9.62 IFNG TNF
11 positive regulation of chemokine production GO:0032722 9.62 IL6 TNF
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 IFNG TNF
13 positive regulation of macrophage activation GO:0043032 9.58 HSPD1 IL10
14 negative regulation of growth of symbiont in host GO:0044130 9.58 IL10 TNF
15 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.55 IL10 TNF
16 endothelial cell apoptotic process GO:0072577 9.54 IL10 TNF
17 negative regulation of cytokine secretion involved in immune response GO:0002740 9.51 IL10 TNF
18 B cell proliferation GO:0042100 9.5 CD79A HSPD1 IL10
19 negative regulation of interleukin-8 production GO:0032717 9.49 BPI IL10
20 immune response GO:0006955 9.43 BPI HLA-B IFNG IL10 IL6 TNF
21 receptor biosynthetic process GO:0032800 9.4 IL10 TNF
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IFNG TNF
23 negative regulation of interleukin-6 production GO:0032715 9.33 BPI IL10 TNF
24 positive regulation of vitamin D biosynthetic process GO:0060557 9.26 IFNG TNF
25 negative regulation of lipid storage GO:0010888 8.8 CRP IL6 TNF

Molecular functions related to Reactive Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IFNG IL10 IL6 TNF

Sources for Reactive Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....