PIRA
MCID: RCT015
MIFTS: 55

Reactive Arthritis (PIRA)

Categories: Bone diseases, Gastrointestinal diseases, Immune diseases, Infectious diseases, Rare diseases
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Aliases & Classifications for Reactive Arthritis

MalaCards integrated aliases for Reactive Arthritis:

Name: Reactive Arthritis 11 19 58 75 14 16
Postdysenteric Arthropathy 11 31
Arthritis, Reactive 43 71
Reiter Syndrome 19 71
Reiter Disease 11 31
Pira 19 75
Post-Infectious Reactive Arthropathy 19
Fiessinger Leroy Reiter Syndrome 11
Post-Dysenteric Arthropathy 71
Post-Bacterial Arthropathy 11
Post-Infectious Arthritis 19
Fiessinger-Leroy Disease 58
Polyarthritis Enterica 58
Arthritis Urethritica 58
Arthritis, Venereal 71
Venereal Arthritis 58
Arthritis Reactive 53
Reiter's Syndrome 19
Reiter's Disease 11
Reiters Syndrome 53

Characteristics:


Inheritance:

Multigenic/multifactorial 58

Prevelance:

1-9/100000 (Worldwide) 58

Age Of Onset:

Adolescent,Adult,Elderly 58

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases


External Ids:

Disease Ontology 11 DOID:6196
ICD9CM 34 099.3 711.30
MeSH 43 D016918
NCIt 49 C34975
SNOMED-CT 68 266212009 56528004
ICD10 31 M02.1 M02.3
MESH via Orphanet 44 D016918
ICD10 via Orphanet 32 M02.3
UMLS via Orphanet 72 C0035012 C0085435
Orphanet 58 ORPHA29207
UMLS 71 C0035012 C0085435 C0152085 more

Summaries for Reactive Arthritis

GARD: 19 Reactive arthritis is a type of infectious arthritis that occurs as a “reaction” to an infection elsewhere in the body. This process may occur weeks or even months after the infection has resolved. In addition to joint inflammation, Reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). These symptoms may occur alone, together, or not at all. The exact cause of Reactive arthritis is unknown. It may follow an infection with Salmonella enteritidis, Salmonella typhimurium, Yersinia enterocolitica, Campylobacter jejuni, Clostridium difficile, Shigella sonnei, Entamoeba histolytica, Cryptosporidium, or Chlamydia trachomatis. Certain genes may make you more prone to the syndrome. For instance, the condition is observed more commonly in patients with human lymphocyte antigen B27 (HLA-B27) histocompatibility antigens.

MalaCards based summary: Reactive Arthritis, also known as postdysenteric arthropathy, is related to spondyloarthropathy 1 and spondylitis. An important gene associated with Reactive Arthritis is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways/superpathways are Innate Immune System and Extracellular matrix organization. The drugs Azithromycin and Rifampicin have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and skin, and related phenotypes are arthritis and joint stiffness

Orphanet: 58 A rare spondyloarthritis characterized by acute or chronic sterile synovitis with or without extra-articular manifestations, becoming manifest after an infection.

Disease Ontology: 11 An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.

Wikipedia 75 Reactive arthritis: Reactive arthritis, also known as Reiter's syndrome, is a form of inflammatory arthritis that develops... more...

Pira: The Irish Republican Army (IRA; Irish: Óglaigh na hÉireann), also known as the Provisional Irish... more...

Related Diseases for Reactive Arthritis

Diseases related to Reactive Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 572)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 1 32.2 TAP2 PRTN3 HSPD1 HP HLA-B CRP
2 spondylitis 31.0 TAP2 HLA-B CRP CCR6
3 tenosynovitis 30.9 PRTN3 HSPD1 CRP
4 synovitis 30.8 PRTN3 MMP8 MMP1 CRP COMP
5 spondyloarthropathy 30.8 PRTN3 HP HLA-B CRP CCR6
6 severe acute respiratory syndrome 30.7 IFNB1 CRP BSG
7 anterior uveitis 30.6 HLA-B CRP CCR6
8 tendinitis 30.6 PRTN3 CRP COMP
9 osteoarthritis 30.6 TIMP1 MMP1 CRP COMP
10 enthesopathy 30.6 HLA-B CRP CCR6
11 ornithosis 30.6 HSPD1 CRP
12 bacteremia 2 30.6 LBP CRP BPI
13 arthritis 30.6 TIMP1 MMP8 MMP1 IFNB1 HSPD1 HLA-B
14 juvenile rheumatoid arthritis 30.5 HSPD1 HP CRP CCR6
15 dysentery 30.5 LTF HP CRP CCR6
16 lyme disease 30.5 IFNB1 HSPD1 CRP
17 arthropathy 30.5 TIMP1 MMP1 CRP COMP CCR6
18 haemophilus influenzae 30.4 OMP LTF
19 exanthem 30.4 PRTN3 HLA-B CRP CCR6
20 toxic shock syndrome 30.3 LBP CRP BPI
21 syphilis 30.3 PRTN3 CRP CCR6
22 cat-scratch disease 30.3 PRTN3 HSPD1 CRP
23 vasculitis 30.2 PRTN3 LTF HSPD1 HLA-B CRP BPI
24 iritis 30.2 HLA-B CRP CCR6
25 endocarditis 30.2 LBP HSPD1 CRP CEACAM8
26 psoriatic arthritis 30.2 TIMP1 MMP1 HLA-B CRP COMP CCR6
27 henoch-schoenlein purpura 30.2 PRTN3 CRP CCR6
28 proctitis 30.2 LTF CRP CCR6
29 meningitis 30.2 TIMP1 LBP HLA-B CRP
30 olecranon bursitis 30.1 HSPD1 CRP
31 autoimmune disease 30.1 PRTN3 IFNB1 HSPD1 HLA-B CRP CCR6
32 kawasaki disease 30.1 TIMP1 HSPD1 CRP
33 infective endocarditis 30.1 PRTN3 CRP CCR6
34 interstitial keratitis 30.1 PRTN3 CRP
35 takayasu arteritis 30.1 HP HLA-B CRP
36 crohn's disease 30.0 LTF HP CRP CCR6
37 sapho syndrome 30.0 CRP CCR6
38 sjogren syndrome 30.0 PRTN3 LTF CCR6
39 bronchiectasis 30.0 MMP8 CRP BPI
40 babesiosis 30.0 HSPD1 HP CRP
41 keratoconjunctivitis 30.0 MMP1 LTF BSG
42 panuveitis 30.0 HLA-B CRP CCR6
43 hypopyon 30.0 HLA-B CRP
44 mastitis 29.9 LTF LBP HP BPI
45 severe cutaneous adverse reaction 29.9 HLA-B CRP CCR6
46 bacterial vaginosis 29.9 MMP8 LTF CCR6
47 relapsing polychondritis 29.9 PRTN3 CRP COMP
48 bacterial meningitis 29.9 TIMP1 MMP8 CRP
49 aortitis 29.9 PRTN3 CRP CCR6
50 hyperthyroidism 29.9 TRH PRTN3 CRP

Graphical network of the top 20 diseases related to Reactive Arthritis:



Diseases related to Reactive Arthritis

Symptoms & Phenotypes for Reactive Arthritis

Human phenotypes related to Reactive Arthritis:

58 30 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthritis 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001369
2 joint stiffness 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001387
3 cognitive impairment 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0100543
4 hyperkeratosis 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0000962
5 arthralgia 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002829
6 joint swelling 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001386
7 conjunctivitis 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0000509
8 osteomyelitis 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002754
9 cartilage destruction 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0100773
10 dystrophic fingernails 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0008391
11 diarrhea 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002014
12 pustule 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0200039
13 recurrent aphthous stomatitis 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0011107
14 enthesitis 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0100686
15 inflammation of the large intestine 58 30 Frequent (33%) Frequent (79-30%)
HP:0002037
16 abdominal pain 58 30 Frequent (33%) Frequent (79-30%)
HP:0002027
17 abnormal pleura morphology 30 Frequent (33%) HP:0002103
18 respiratory insufficiency 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002093
19 photophobia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000613
20 fever 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001945
21 recurrent urinary tract infections 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000010
22 pericarditis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001701
23 weight loss 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001824
24 aortic regurgitation 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001659
25 pulmonary fibrosis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002206
26 abnormality of the nail 58 Very frequent (99-80%)
27 abnormality of the pleura 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Reactive Arthritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 BSG CCR6 CEACAM8 COMP CRP HP
2 immune system MP:0005387 9.83 ADGRE5 BSG CCR6 COMP CRP HLA-B
3 hematopoietic system MP:0005397 9.4 ADGRE5 BSG CCR6 HLA-B HP HSPD1

Drugs & Therapeutics for Reactive Arthritis

Drugs for Reactive Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 3 83905-01-5 447043
2
Rifampicin Approved Phase 3 13292-46-1 135512673 5381226 135900090
3
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
4 Anti-Bacterial Agents Phase 3
5 Anti-Infective Agents Phase 3
6 Antibiotics, Antitubercular Phase 3
7 Antiprotozoal Agents Phase 3
8 Antiparasitic Agents Phase 3
9 Antimalarials Phase 3
10 Antitubercular Agents Phase 3
11
Infliximab Approved Phase 2 170277-31-3
12
Licorice Approved Phase 1, Phase 2
13
Turmeric Approved, Experimental, Investigational Phase 1, Phase 2
14
Glycerin Approved, Investigational Phase 2 56-81-5 753
15 Gastrointestinal Agents Phase 2
16 Antiviral Agents Phase 2
17 Antirheumatic Agents Phase 2
18 interferons Phase 2
19 Interferon-gamma Phase 2
20 Tumor Necrosis Factor Inhibitors Phase 2
21 Dermatologic Agents Phase 2
22 Astragalus Phase 1, Phase 2
23 Skullcap Phase 1, Phase 2
24 Turmeric extract Phase 1, Phase 2
25 Hawthorn Phase 1, Phase 2
26 Chinese Yam Phase 1, Phase 2
27 Chinese Salvia Phase 1, Phase 2
28 Chinese Rhubarb Phase 1, Phase 2
29 Vaccines Phase 1
30
Rifaximin Approved, Investigational 80621-81-4 46783403 6436173
31
Levofloxacin Approved, Investigational 100986-85-4 149096
32
Ofloxacin Approved 82419-36-1 4583
33
Roxithromycin Approved, Investigational, Withdrawn 80214-83-1 6915744
34
Leflunomide Approved, Investigational 75706-12-6 3899
35
Azathioprine Approved 446-86-6 2265
36
Methotrexate Approved 1959-05-2, 59-05-2 4112 126941
37
Mycophenolic acid Approved, Investigational 24280-93-1 446541
38
Sulfasalazine Approved 599-79-1 5353980 5339 5359476
39 Cytochrome P-450 Enzyme Inhibitors
40 Immune Checkpoint Inhibitors
41
Salicylates
42 Anesthetics

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Phase 3 Trial to Assess the Efficacy of Long-term (6 Months) Combination Antibiotics as a Treatment for Chlamydia-induced Reactive Arthritis Completed NCT00351273 Phase 3 Doxycycline and Rifampin;Azithromycin and Rifampin;Placebo
2 New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis: Immunostimulation Plus Antibiotic Versus Immunosuppression Plus Antibiotic Versus Conventional Standardtherapy Unknown status NCT00244179 Phase 2 interferon-gamma;infliximab;dmard
3 Treating Sequalae Caused by Post-acute Sequelae of SARS (Severe Acute Respiratory Syndrome)-CoV-2 Infection Recruiting NCT04846010 Phase 1, Phase 2
4 Safety and Clinical Efficacy Associated With Faecal Microbiota Transplantation Performed in Treatment-naïve Patients With Newly Diagnosed Rheumatoid Arthritis, Reactive Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Gouty Arthritis, Psoriasis, Hidradenitis Suppurativa, Pulmonary Sarcoidosis, Crohn's Disease, and Ulcerative Colitis: a 52-week, Double-blind, Randomised, Placebo-controlled, Exploratory Trial Not yet recruiting NCT04924270 Phase 2
5 Phase 1 Two Stage Randomized, Double-blind, Placebo Controlled Dose- and Schedule Ranging Trial to Assess the Acute Safety, Tolerability, and Immunogenicity of a Live, Attenuated Shigella/ETEC Combination Vaccine Delivered Orally to Healthy Adults Age 18 to 45 Years Old Completed NCT05409196 Phase 1 Placebo
6 A Randomized, Placebo-Controlled, Double-Blind, Clinical Trial Evaluating Two Dose Regimens of Rifaximin (550 mg Daily or 550 mg Twice Daily) for Chemoprophylaxis Against Travelers' Diarrhea (TD) Among Active Duty Deployed U.S. and British Military Personnel Unknown status NCT02498301 Rifaximin;Placebo
7 Double-Blind, Placebo-Controlled Study of Three-Month Treatment With the Combination of Ofloxacin and Roxithromycin in Recent-Onset Reactive Arthritis Completed NCT00621387 ofloxacin and roxithromycin;placebo
8 Barriers and Facilitators of Flu, Pneumonia and SARS-CoV-2 (COVID-19) Vaccination in Adults With Inflammatory Conditions Treated With Immune-suppressing Drugs Completed NCT05115370
9 Late Cardial Assessment in Children Who Were Diagnosed With Post Streptococcal Reactive Arthritis - a Long Term Study Completed NCT01179451
10 A Bicentre Retrospective Study of Features and Outcomes of Patients With Reactive Arthritis Completed NCT03926429
11 Prognostic Indicators and Determinants of the 2-5 Year Outcome in a Cohort of Early Synovitis Patients Completed NCT00001679
12 The Pathogenesis of Inflammatory Synovitis: A Study of Early Arthritis Completed NCT00001375
13 Testing of an Educational Tool for Patients With Melanoma and Concomitant Autoimmune Disease Who Are Candidates for Adjuvant Therapy With Immune Checkpoint Inhibitors: Acceptability and Usability With Patients and Providers Recruiting NCT04751396
14 Rheumatology Patient Registry and Biorepository Recruiting NCT04402086
15 Exploring Patient and Healthcare Professional Views and Experiences of the Current and Recommended Monitoring Strategies for Inflammatory Conditions Treated With Commonly Used Immune Suppressing Drugs Recruiting NCT05458531
16 A Pilot Randomized Control Trial Testing the Acceptability and Feasibility of a Pediatric Interactive Relational Agent (PIRA) vs. Standard Preoperative Education Recruiting NCT04586569

Search NIH Clinical Center for Reactive Arthritis

Cochrane evidence based reviews: arthritis, reactive

Genetic Tests for Reactive Arthritis

Anatomical Context for Reactive Arthritis

Organs/tissues related to Reactive Arthritis:

MalaCards : Bone, T Cells, Skin, Monocytes, Eye, Heart, Neutrophil

Publications for Reactive Arthritis

Articles related to Reactive Arthritis:

(show top 50) (show all 4703)
# Title Authors PMID Year
1
Evaluation of the appropriateness of composite disease activity measures for assessment of psoriatic arthritis. 53 62
19762363 2010
2
[Some proteins of acute phase of inflammation in differential diagnostics of rheumatoid arthritis]. 53 62
18720714 2008
3
Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage damage and/or the therapeutic efficacy of treatments. 53 62
17894003 2007
4
Serum levels of cartilage oligomeric matrix protein (COMP): a rapid decrease in patients with active rheumatoid arthritis undergoing intravenous steroid treatment. 53 62
16485108 2006
5
Undifferentiated spondyloarthropathy in Chinese patients. 53 62
16513489 2006
6
Expression of interferon beta in synovial tissue from patients with rheumatoid arthritis: comparison with patients with osteoarthritis and reactive arthritis. 53 62
15878901 2005
7
Serum levels of cartilage oligomeric matrix protein are elevated in rheumatoid arthritis, but not in inflammatory rheumatic diseases such as psoriatic arthritis, reactive arthritis, Raynaud's syndrome, scleroderma, systemic lupus erythematosus, vasculitis and Sjögren's syndrome. 53 62
15059267 2004
8
Importance of species-specific antigens in the serodiagnosis of Chlamydia trachomatis reactive arthritis. 53 62
12209035 2002
9
IgM, IgG, and IgA response to enterobacteria in patients with ankylosing spondylitis in southern India. 53 62
12021151 2002
10
Multispecific CD4+ T cell response to a single 12-mer epitope of the immunodominant heat-shock protein 60 of Yersinia enterocolitica in Yersinia-triggered reactive arthritis: overlap with the B27-restricted CD8 epitope, functional properties, and epitope presentation by multiple DR alleles. 53 62
10640771 2000
11
BPI-ANCA is found in reactive arthritis caused by Yersinia and Salmonella infection and recognise exclusively the C-terminal part of the BPI molecule. 53 62
11028843 2000
12
Anti-lactoferrin antibodies and other types of anti-neutrophil cytoplasmic antibodies (ANCA) in reactive arthritis and ankylosing spondylitis. 53 62
10469064 1999
13
Expression of the activation antigen CD97 and its ligand CD55 in rheumatoid synovial tissue. 53 62
10211878 1999
14
TAP2 alleles in inflammatory arthritis. 53 62
9645419 1998
15
Identification and characterization of a DR4-restricted T cell epitope within chlamydia heat shock protein 60. 53 62
9328119 1997
16
Antigen-dependent B cell differentiation in the synovial tissue of a patient with reactive arthritis. 53 62
9131588 1997
17
Prediction of diagnosis in acute and subacute oligoarthritis of unknown origin. 53 62
8624640 1996
18
Autoantibodies to human heat shock protein (hsp)60 may be induced by Escherichia coli groEL. 53 62
8608642 1996
19
[Blood prolactin under the effect of protirelin in spondylarthropathies. Treatment trial of 4 cases of reactive arthritis and 2 cases of psoriatic arthritis with bromocriptine]. 53 62
8763085 1996
20
TAP1 and TAP2 polymorphism in HLA-B27-positive subpopulations: no allelic differences in ankylosing spondylitis and reactive arthritis. 53 62
8770637 1995
21
Oncogene expression in synovial fluid cells in reactive and early rheumatoid arthritis: a brief report. 53 62
7582717 1995
22
Lipopolysaccharide binding protein as a marker of inflammation in synovial fluid of patients with arthritis: correlation with interleukin 6 and C-reactive protein. 53 62
7562749 1995
23
[Prolactin response to protirelin in reactive arthritis and ankylosing spondyloarthritis. Failure of treatment of 4 reactive arthritis with bromocriptine]. 53 62
7858584 1994
24
In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis. 53 62
7923879 1994
25
[Relative hyperprolactinemia under protirelin in reactive arthritis. Preliminary results]. 53 62
7971809 1994
26
Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis. 53 62
8192476 1994
27
Serum antibodies from patients with ankylosing spondylitis and Reiter's syndrome are reactive with HLA-B27 cells transfected with the Mycobacterium tuberculosis hsp60 gene. 53 62
7905462 1994
28
Responses to gram negative enteric bacterial antigens by synovial T cells from patients with juvenile chronic arthritis: recognition of heat shock protein HSP60. 53 62
7693941 1993
29
Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. 53 62
1634773 1992
30
IgG and IgA antibody responses against porins in Yersinia-triggered reactive arthritis. 53 62
1316199 1992
31
Cytidine deaminase and lactoferrin in inflammatory synovial fluids. Indicators of local polymorphonuclear cell function? 53 62
1555038 1992
32
Does reduced erythrocyte C3b receptor (CR1) activity contribute to the pathogenesis of yersinia triggered reactive arthritis? 53 62
1531747 1992
33
Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis, and systemic lupus erythematosus. 53 62
1384103 1992
34
Salmonella-specific antibodies in reactive arthritis. 53 62
1955713 1991
35
Analysis of function-associated receptor molecules on peripheral blood and synovial fluid granulocytes from patients with rheumatoid and reactive arthritis. 53 62
1918267 1991
36
[A comparative study of serum complement (C3 and C4) in inflammatory joint diseases]. 53 62
1706901 1990
37
Evaluation of clinical and paraclinical findings in patients with reactive arthritis caused by giardiasis: A systematic review. 62
36174478 2022
38
Cutaneous and rheumatological manifestations of reactive arthritis: A case report. 62
36381024 2022
39
Poncet's Disease (Reactive Arthritis Associated with Tuberculosis). 62
35342140 2022
40
Schistosomiasis and Recurrent Arthritis: A Systematic Review of the Literature. 62
36422620 2022
41
Back-to-back: The co-occurrence of DISH and ankylosing spondylitis from early modern Poland. 62
36375277 2022
42
Serologic Biomarkers of Progression Toward Diagnosis of Rheumatoid Arthritis in Active Component Military Personnel. 62
35671369 2022
43
Revisiting the antiviral theory to explain interferon-beta's effectiveness for relapsing multiple sclerosis. 62
36116383 2022
44
Fabrication of lateral flow immunoassay strip for rapid detection of acute hepatopancreatic necrosis disease. 62
36033912 2022
45
Purification, characterization and toxicity assessment of PirAB toxins from Photorhabdus akhurstii subsp. akhurstii K-1. 62
36167186 2022
46
Post-streptococcal Reactive Arthritis Visually Emphasizing Enthesitis. 62
36261371 2022
47
Arthritis after SARS-CoV-2 infection: reactive arthritis or virally mediated arthritis? 62
36210396 2022
48
[Reactive arthritis with SARS-COV-2 as a trigger]. 62
35079258 2022
49
[History of reactive arthritis. Historical milestones and future]. 62
36006472 2022
50
Reactive arthritis with SARS-COV-2 as a trigger. 62
35562296 2022

Variations for Reactive Arthritis

Expression for Reactive Arthritis

Search GEO for disease gene expression data for Reactive Arthritis.

Pathways for Reactive Arthritis

GO Terms for Reactive Arthritis

Cellular components related to Reactive Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.34 ADGRE5 BPI BSG CEACAM8 COMP HLA-B
2 extracellular region GO:0005576 10.05 ADGRE5 BPI COMP CRP HP IFNB1
3 tertiary granule lumen GO:1904724 9.85 MMP8 LTF HP
4 specific granule lumen GO:0035580 9.76 MMP8 LTF HP BPI
5 extracellular space GO:0005615 9.72 TIMP1 PRTN3 MMP8 LTF LBP IFNB1
6 sperm plasma membrane GO:0097524 9.62 HSPD1 CCR6

Biological processes related to Reactive Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of chondrocyte proliferation GO:1902732 9.56 LTF COMP
2 opsonization GO:0008228 9.46 LBP CRP
3 collagen catabolic process GO:0030574 9.43 PRTN3 MMP8 MMP1
4 acute-phase response GO:0006953 9.1 LBP HP CRP

Molecular functions related to Reactive Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.65 PRTN3 MMP8 MMP1 LTF HP
2 lipopolysaccharide binding GO:0001530 9.23 LTF LBP HSPD1 BPI

Sources for Reactive Arthritis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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