Reactive Arthritis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

PIRA MCID: RCT015 MIFTS: 64	Reactive Arthritis (PIRA) Categories: Bone diseases, Gastrointestinal diseases, Rare diseases
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Aliases & Classifications for Reactive Arthritis

MalaCards integrated aliases for Reactive Arthritis:

Name: Reactive Arthritis ¹² ⁷⁶ ⁵³ ⁵⁹ ¹⁵

Reiter Syndrome ⁵³ ⁵⁹ ⁷³

Arthritis, Reactive ⁴⁴ ⁷³

Reiter Disease ¹² ⁵⁹

Post-Infectious Reactive Arthropathy ⁵³

Fiessinger Leroy Reiter Syndrome ¹²

Fiessinger-Leroy-Reiter Syndrome ⁵⁹

Post-Dysenteric Arthropathy ⁷³

Post-Bacterial Arthropathy ¹²

Postdysenteric Arthropathy ¹²

Post-Infectious Arthritis ⁵³

Fiessinger-Leroy Disease ⁵⁹

Polyarthritis Enterica ⁵⁹

Arthritis Urethritica ⁵⁹

Arthritis, Venereal ⁷³

Venereal Arthritis ⁵⁹

Arthritis Reactive ⁵⁵

Reiter's Syndrome ⁵³

Reiter's Disease ¹²

Reiters Syndrome ⁵⁵

Pira ⁵³

Characteristics:

Orphanet epidemiological data:

⁵⁹

reactive arthritis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³³ ³⁴

Diseases of the musculoskeletal system and connective tissue

Infectious arthropathies

Reactive arthropathies

Postdysenteric arthropathy

Reiter disease

Orphanet: ⁵⁹

Rare systemic and rhumatological diseases

External Ids:

Disease Ontology ¹² DOID:6196

ICD10 ³³ M02.1 M02.10 M02.3 more

ICD9CM ³⁵ 099.3 711.3 711.30

MeSH ⁴⁴ D016918

NCIt ⁵⁰ C34975

SNOMED-CT ⁶⁸ 56528004 67224007

Orphanet ⁵⁹ ORPHA29207

MESH via Orphanet ⁴⁵ D016918

UMLS via Orphanet ⁷⁴ C0035012 C0085435

ICD10 via Orphanet ³⁴ M02.3

SNOMED-CT via HPO ⁶⁹ 197927001 9826008 246622003 more

UMLS ⁷³ C0035012 C0152085 C0085435 more

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Summaries for Reactive Arthritis

NIH Rare Diseases : ⁵³ Reactive arthritis is a type of infectious arthritis that occurs as a �??reaction�?� to an infection elsewhere in the body. This process may occur weeks or even months after the infection has resolved. In addition to joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). These symptoms may occur alone, together, or not at all. The symptoms of reactive arthritis usually last 3 to 12 months, although symptoms can return or develop into a long-term disease in a small percentage of people. The exact cause of reactive arthritis is unknown. It may follow an infection with Salmonella enteritidis, Salmonella typhimurium, Yersinia enterocolitica, Campylobacter jejuni, Clostridium difficile, Shigella sonnei, Entamoeba histolytica, Cryptosporidium, or Chlamydia trachomatis. Certain genes may make you more prone to the syndrome. For instance, the condition is observed more commonly in patients with human lymphocyte antigen B27 (HLA-B27) histocompatibility antigens. The goal of treatment is to relieve symptoms and treat any underlying infection. Antibiotics may be prescribed. Nonsteroidal anti-inflammatory drugs (NSAIDS), pain relievers, and corticosteroids may be recommended for those with joint pain.

MalaCards based summary : Reactive Arthritis, also known as reiter syndrome, is related to spondyloarthropathy 1 and arthritis. An important gene associated with Reactive Arthritis is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include t cells, eye and bone, and related phenotypes are respiratory insufficiency and arthritis

Disease Ontology : ¹² An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.

Wikipedia : ⁷⁶ Reactive arthritis, formerly known as Reiter''s syndrome, is a form of inflammatory arthritis that... more...

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Related Diseases for Reactive Arthritis

Diseases related to Reactive Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 308)

#	Related Disease	Score	Top Affiliating Genes
1	spondyloarthropathy 1	32.8	CRP HLA-B IL17A TNF
2	arthritis	31.5	IFNG IL10 IL17A TNF
3	spondylitis	30.3	CRP HLA-B IL17A TNF
4	chlamydia	30.2	CRP HSPD1 IFNG IL10 TNF
5	rheumatic fever	30.0	HP IL10 TNF
6	colitis	29.9	IFNG IL10 IL17A TNF
7	spondyloarthropathy	29.9	HLA-B IFNG IL10 IL17A TNF
8	uveitis	29.8	HLA-B IFNG IL10 IL17A TNF
9	anterior uveitis	29.8	HLA-B TNF
10	gastroenteritis	29.7	CRP IL10 TNF
11	multifocal choroiditis	29.7	IL10 TNF
12	choroiditis	29.7	IL10 TNF
13	haemophilus influenzae	29.7	OMP TNF
14	toxic shock syndrome	29.6	IFNG IL10 TNF
15	viral infectious disease	29.6	IFNG IL10 TNF
16	cat-scratch disease	29.6	HSPD1 IFNG
17	vasculitis	29.5	BPI CRP HLA-B TNF
18	rheumatoid arthritis	29.4	COMP CRP HLA-B IFNG IL10 IL17A
19	rheumatic heart disease	29.4	HLA-B IL10 TNF
20	tenosynovitis	29.4	COMP CRP
21	synovitis	29.4	COMP CRP TNF
22	human immunodeficiency virus infectious disease	29.4	IFNG IL10 TNF
23	pneumonia	29.4	CRP IL10 TNF
24	psoriatic arthritis	29.4	COMP CRP HLA-B IL17A TNF
25	arthropathy	29.4	COMP CRP TNF
26	osteomyelitis	29.4	IFNG IL10 TNF
27	kawasaki disease	29.2	CRP HSPD1 IL10 TNF
28	brucellosis	29.2	CRP IFNG IL10 TNF
29	peritonitis	29.1	CRP IL10 TNF
30	systemic lupus erythematosus	29.1	CRP IFNG IL10 IL17A TNF
31	meningitis	29.0	CRP IFNG IL10 OMP TNF
32	psoriasis	29.0	IFNG IL10 IL17A TNF
33	leptospirosis	29.0	CRP IFNG IL10 TNF
34	inflammatory bowel disease	28.9	BPI CRP HLA-B IFNG IL10 IL17A
35	appendicitis	28.9	CRP IL10 MMP8 TNF
36	bacterial meningitis	28.9	CRP IL10 MMP8 TNF
37	rheumatic disease	28.8	CRP HLA-B IFNG IL10 TNF
38	septic arthritis	11.8
39	shigellosis	11.1
40	idiopathic bronchiectasis	10.3	HLA-B IFNG
41	asymptomatic neurosyphilis	10.3	IFNG IL17A
42	myositis fibrosa	10.3	IFNG IL17A
43	nontuberculous mycobacterial lung disease	10.2	HLA-B TNF
44	rheumatoid lung disease	10.2	IL17A TNF
45	crohn's colitis	10.2	IFNG TNF
46	meconium aspiration syndrome	10.2	IFNG TNF
47	cardiac sarcoidosis	10.2	IFNG TNF
48	scleritis	10.2	IFNG TNF
49	miliary tuberculosis	10.2	IFNG TNF
50	soft tissue sarcoma	10.2	IFNG TNF

Graphical network of the top 20 diseases related to Reactive Arthritis:

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Symptoms & Phenotypes for Reactive Arthritis

Human phenotypes related to Reactive Arthritis:

⁵⁹ ³² (show all 26)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	respiratory insufficiency ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0002093
2	arthritis ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0001369
3	joint stiffness ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0001387
4	cognitive impairment ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0100543
5	photophobia ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0000613
6	fever ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0001945
7	joint swelling ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0001386
8	pulmonary fibrosis ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0002206
9	arthralgia ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0002829
10	abdominal pain ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0002027
11	hyperkeratosis ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0000962
12	weight loss ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0001824
13	abnormality of the pleura ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0002103
14	inflammation of the large intestine ⁵⁹ ³²	frequent (33%)	Frequent (79-30%)	HP:0002037
15	osteomyelitis ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0002754
16	diarrhea ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0002014
17	pericarditis ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0001701
18	conjunctivitis ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0000509
19	recurrent urinary tract infections ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0000010
20	cartilage destruction ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0100773
21	dystrophic fingernails ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0008391
22	aortic regurgitation ⁵⁹ ³²	occasional (7.5%)	Occasional (29-5%)	HP:0001659
23	recurrent aphthous stomatitis ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0011107
24	pustule ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0200039
25	enthesitis ⁵⁹ ³²	hallmark (90%)	Very frequent (99-80%)	HP:0100686
26	abnormality of the nail ⁵⁹		Very frequent (99-80%)

MGI Mouse Phenotypes related to Reactive Arthritis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.85	COMP CRP HP IFNG IL10 IL17A
2	immune system	MP:0005387	9.56	COMP CRP HP IFNG IL10 IL17A
3	no phenotypic analysis	MP:0003012	9.1	IFNG IL10 IL17A OMP TNF TRH

Sources

Drugs & Therapeutics for Reactive Arthritis

Drugs for Reactive Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Azithromycin

Approved

Phase 3

83905-01-5

55185 447043

Synonyms:

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranoside

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside

121470-24-4

1-Oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-,(2R-(2R*,3S*

75199_FLUKA

83905-01-5

9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A

AC-16014

AC1L9KEG

Aritromicina

Azadose

Azasite

Azenil

Azifast

Azigram

Azimakrol

Azithramycine

azithromycin

Azithromycin & Tumor Necrosis Factor

Azithromycin (AIDS Initiative)

Azithromycin (anhydrous)

Azithromycin dihydrate

Azithromycin monohydrate

Azithromycin Monohydrate

Azithromycin pfizer brand

Azithromycine

Azithromycinum

Azitrocin

Azitromax

Azitromicina

Azitromin

Azythromycin

Bayer brand OF azithromycin dihydrate

BIDD:GT0792

Bio-0676

BRN 5387583

BSPBio_002285

C38H72N2O12

CCRIS 1961

CHEBI:2955

CHEMBL529

CID447043

CP62,993

CP-62993

CPD000471864

DCH3

Dihydrate, azithromycin

DivK1c_000233

DRG-0104

Funk brand OF azithromycin dihydrate

Goxal

Hemomycin

HMS1922G12

HMS2094M11

HMS500L15

HSDB 7205

IDI1_000233

KBio1_000233

KBio2_000787

KBio2_003355

KBio2_005923

KBio3_001505

KBioGR_000731

KBioSS_000787

Lesvi brand OF azithromycin dihydrate

LS-1834

Mack brand OF azithromycin dihydrate

Misultina

MLS001055353

MLS001066331

MLS001201763

MLS001304005

MLS001332499

MLS001332500

MolPort-002-507-426

Monohydrate, azithromycin

NCGC00090753-01

NCGC00090753-02

NINDS_000233

NSC643732

Pfizer brand OF azithromycin

Pfizer brand OF azithromycin dihydrate

Pharmacia brand OF azithromycin dihydrate

SAM002589961

SMR000471864

SPBio_001544

Spectrum_000307

SPECTRUM1503679

Spectrum2_001582

Spectrum3_000653

Spectrum4_000186

Spectrum5_001867

Sumamed

Toraseptol

Tromix

Ultreon

UNII-JTE4MNN1MD

Vinzam

Vita brand OF azithromycin dihydrate

XZ-450

Zentavion

ZIT

Zithromac

Zithromax

Zithromax IV

Zithromycin

Zitromax

Zitromax Avium 600

Zmas

Zmax

Z-Pak

Doxycycline

Approved, Investigational, Vet_approved

Phase 3

564-25-0

54671203

Synonyms:

(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

(4S,4AR,5S,5ar,6R,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

10597-92-9

17086-28-1 (mono-hydrate)

24390-14-5

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)

41411-66-9 (6-epimer, mono-hydrochloride)

564-25-0

5-Hydroxy-a-6-deoxytetracycline

5-Hydroxy-alpha-6-deoxytetracycline

5-hydroxy-α-6-deoxytetracycline

5-Hydroxy-α-6-deoxytetracycline

69935-17-7 (mono-hydrochloride, di-hydrate)

6a-Deoxy-5-oxytetracycline

6alpha-deoxy-5-oxytetracycline

6-alpha-deoxy-5-oxytetracycline

6alpha-Deoxy-5-oxytetracycline

6-alpha-Deoxy-5-oxytetracycline

6-Deoxyoxytetracycline

6-Deoxytetracycline

6α-deoxy-5-oxytetracycline

7164-70-7

7264-10-0

94088-85-4 (calcium salt (1:2))

AB08 (*Fosfatex)

AC1NQXW7

AC1NS4CW

AC1NUYS8

AC1O8PYM

alpha-6-Deoxy-5-hydroxytetracycline

alpha-6-Deoxyoxytetracycline

alpha-Doxycycline

Alti-Doxycycline

Anhydrous doxycycline

Apo-Doxy

Atridox

Azudoxat

BCBcMAP01_000024

BIDD:GT0146

BMY-28689

BPBio1_000951

BSPBio_000863

BSPBio_001936

BU-3839T

C06973

CHEBI:50845

CHEMBL1433

CID5281011

CID5353597

CID5463943

CID6713981

CPD001550033

D07876

DB00254

Deoxymykoin

DivK1c_000345

DMSC (*Fosfatex)

Dossiciclina

Dossiciclina [DCIT]

Doxcycline anhydrous

DOXCYCLINE ANHYDROUS

Doxiciclina

Doxiciclina [INN-Spanish]

Doxiciclina [Italian]

Doxitard

Doxivetin

DOXY

Doxy-Caps

Doxycen

Doxychel

Doxychel (TN)

Doxycin

Doxycyclin

doxycycline

Doxycycline (200mg/day) or Placebo

Doxycycline (anhydrous)

Doxycycline (INN)

Doxycycline (internal use)

Doxycycline (TN)

Doxycycline anhydrous

DOXYCYCLINE CALCIUM

Doxycycline hyclate

Doxycycline monohydrate

DOXYCYCLINE MONOHYDRATE

Doxycycline-Chinoin

Doxycyclinum

Doxycyclinum [INN-Latin]

Doxy-Puren

Doxysol

Doxy-Tabs

Doxytec

Doxytetracycline

EINECS 209-271-1

GS-3065 (*monohydrate)

HMS2090E06

HSDB 3071

Hydramycin

IDI1_000345

Investin

Jenacyclin

KBio1_000345

KBio2_001287

KBio2_003855

KBio2_006423

KBio3_001156

KBioGR_001133

KBioSS_001287

Liviatin

Lopac0_000405

LS-187766

LS-93868

MolPort-002-507-423

Monodox

Monodox (*monohydrate)

NCGC00161602-01

NCGC00161602-03

NCGC00161602-04

NCGC00167961-01

NCGC00179395-01

NINDS_000345

Novo-Doxylin

NSC633557

Nu-Doxycycline

Oracea

Prestwick0_000852

Prestwick1_000852

Prestwick2_000852

Prestwick3_000852

Ronaxan

SAM002589932

SMP1_000107

Spanor

SPBio_000246

SPBio_002784

Spectrum_000807

Spectrum2_000143

Spectrum3_000408

Spectrum4_000527

Spectrum5_000947

STOCK1N-34341

Supracyclin

UNII-334895S862

UPCMLD-DP021

UPCMLD-DP021:001

Vibramycin

Vibramycin (*monohydrate)

Vibramycin Novum

Vibramycine

Vibra-tabs

Vibravenos

Vivox (*Hyclate)

Rifampicin

Approved

Phase 3

13292-46-1

5458213 5381226

Synonyms:

13292-46-1

1-b]furan-21-yl acetate

3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin

3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV

3-([(4-Methyl-1-piperazinyl)imino]methyl)rifamycin SV

3-(4-Methylpiperazinyliminomethyl)rifamycin SV

3-(4-Methylpiperazinyliminomethyl)-rifamycin SV

3-[(4-Methyl-1-piperazinyl)iminomethyl]rifamycin SV

3-[[(4-Methyl-1-piperazinyl)imino]-methyl]rifamycin

46713_FLUKA

46713_RIEDEL

62534-43-4

8-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV

8-(4-Methylpiperazinyliminomethyl) rifamycin SV

8-[[(4-Methyl-1-piperazinyl)imino[methyl]rifamycin

8-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin sv

8-[[(4-Methylpiperazinyl)imino]methyl]rifamycin sv

83907_FLUKA

83907_SIGMA

8CI)

Abrifam

Archidyn

Arficin

Arzide

AZT + Rifampin

Ba 41166

Ba 41166/E

BA-41166E

Benemicin

Benemycin

BIDD:PXR0014

Bio-0621

BPBio1_000561

BSPBio_000509

C06688

C43H58N4O12

CAS-13292-46-1

CCRIS 551

CHEBI:28077

CHEBI:455936

CHEMBL180

CID5381226

CID5388984

CID5458213

CID5702112

CID6604339

CID6708473

CID6842115

CID6912767

CID6913622

CPD001906767

D00211

DB01045

Dione 21-acetate

Dipicin

DivK1c_000550

Doloresum

DRG-0109

EINECS 236-312-0

Eremfat

Famcin

Fenampicin

HMS1569J11

HMS1920P08

HMS2089F12

HMS2092G09

HMS501L12

HSDB 3181

KBio1_000550

KBio2_000919

KBio2_003487

KBio2_006055

KBio3_003018

KBioGR_001780

KBioSS_000919

L-5103

L-5103 Lepetit

LS-7689

MLS000028552

MLS001148237

MLS001333745

MolPort-000-767-051

MolPort-002-513-586

MolPort-003-666-281

MolPort-006-395-891

NCGC00016699-01

NCGC00017365-01

NCGC00018178-01

NCGC00022678-03

NCGC00022678-04

NCGC00022678-05

NCGC00160500-01

nchembio884-comp4

NCI60_000309

NINDS_000550

NSC 113926

NSC113926

NSC-113926

Piperine & Rifampicin

Prestwick_833

Prestwick0_000525

Prestwick1_000525

Prestwick2_000525

Prestwick3_000525

R/AMP

R0079

R3501_SIAL

R3501_SIGMA

R5777_SIGMA

R7382_SIGMA

Ramp

RAMP

R-Cin

Reserpine & Rifampicin

Rfamipicin

RFP

Rifa

Rifadin

Rifadin (TN)

Rifadin I.V

Rifadin I.V.

Rifadin Iv

Rifadin IV

Rifadin, Rimactane, Rifampicin, Rifampin

Rifadine

Rifagen

Rifaldazin

Rifaldazine

Rifaldin

Rifam

Rifamicin AMP

Rifamor

Rifampicin

Rifampicin & EEP

Rifampicin & Propolis

Rifampicin (JP15/INN)

Rifampicin [INN:BAN:JAN]

Rifampicin SV

Rifampicina

Rifampicina [INN-Spanish]

Rifampicine

Rifampicine [French]

Rifampicinum

Rifampicinum [INN-Latin]

rifampin

Rifampin

Rifampin (USP)

Rifampin [USAN]

Rifamsolin

Rifamycin

Rifamycin Amp

Rifamycin AMP

Rifaprodin

Rifcin

Rifinah

Rifobac

Rifoldin

Rifoldine

Riforal

Rimactan

Rimactane

Rimactane (TN)

Rimactazid

Rimactin

Rimactizid

Rimazid

Rimycin

RMP

Rofact

S1764_Selleck

SAM002264646

Sinerdol

SMR000058322

SMR000653525

SPBio_002430

Spectrum_000439

SPECTRUM1500529

Spectrum3_001837

Spectrum4_001250

Spectrum5_002018

STK080143

TNP00313

Tubocin

UNII-VJT6J7R4TR

WLN: V1 WQ A&1 E&1 E1UN- AT6N DNTJ D1

Antibiotics, Antitubercular

Phase 3,Phase 2,Not Applicable

Anti-Infective Agents

Phase 3,Phase 2,Not Applicable

Anti-Bacterial Agents

Phase 3,Phase 2,Not Applicable

Nucleic Acid Synthesis Inhibitors

Phase 3,Not Applicable

Antiprotozoal Agents

Phase 3

Cytochrome P-450 CYP3A Inducers

Phase 3

Antiparasitic Agents

Phase 3

Antitubercular Agents

Phase 3

Antimalarials

Phase 3

Infliximab

Approved

Phase 2

170277-31-3

Antiviral Agents

Phase 2

Interferon-gamma

Phase 2

interferons

Phase 2

Dermatologic Agents

Phase 2

Antirheumatic Agents

Phase 2

Gastrointestinal Agents

Phase 2,Not Applicable

Vaccines

Phase 2,Phase 1,Not Applicable

Immunologic Factors

Phase 2,Phase 1

Levofloxacin

Approved, Investigational

Not Applicable

100986-85-4

149096

Synonyms:

(&#8722

(-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid

(-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7Hpyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hemihydrate

(-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridol[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hemihydrate

(-)-Ofloxacin

(3S)-(-)-9-fluoro-3-Methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate

(3S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid

(3S)-(-)-9-fluoro-3-Methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid

(3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

(R)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid

(R)-isomer

(S)-(-)-9-fluoro-3-Methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylate

(S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid

(S)-(-)-9-fluoro-3-Methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid

(S)-(-)-Ofloxacin

(S)-9-fluoro-2,3-dihydro-3-Methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylate

(S)-9-fluoro-2,3-dihydro-3-Methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid

(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid

(S)-Ofloxacin

)-Ofloxacin

100986-85-4

100986-86-5

28266_FLUKA

28266_SIGMA

AC1L3YF8

AC-7593

Aeroquin

Ambap100986-85-4

Anhydrous, levofloxacin

BRD-K09471561-001-06-7

BSPBio_002689

C07660

C18H20FN3O4

C18H20FN3O4.H2O

CCRIS 4073

CCRIS 4074

CHEMBL33

CID149096

CPD000466387

Cravit

Cravit (TN)

Cravit Ophthalmic

D08120

DB01137

d-Levofloxacin

DR 3354

DR3355

DR-3355

DR-3355: L-isomer of ofloxacin

Elequine

Floxacin

Floxel

Floxin

HMS1922J07

HMS2051G04

HMS2090O10

HMS2093E18

HR 355

HR-355

Iquix

KBio2_002199

KBio2_004767

KBio2_007335

KBio3_001909

KBioGR_001605

KBioSS_002199

L0193

Leroxacin

Lesacin

Levaquin

LEVAQUIN IN DEXTROSE 5% IN PLASTIC CONTAINER

LEVOFLOXACIN

Levofloxacin (INN)

Levofloxacin [USAN:INN:JAN]

Levofloxacin anhydrous

Levofloxacin hydrate

Levofloxacin tablet, suspension or intravenous

Levofloxacine

Levofloxacine [INN-French]

Levofloxacino

Levofloxacino [INN-Spanish]

Levofloxacinum

Levofloxacinum [INN-Latin]

Levokacin

Levox

Levoxacin

LFX

L-Ofloxacin

LS-133260

LS-171761

LVX

MLS000759524

MLS001165709

MLS001423977

MolPort-002-885-835

Mosardal

MP-376

NCGC00178529-01

Nofaxin

Ofloxacin

Ofloxacin S-(-)-form

Ofloxacin, (S)-isomer

Oftaquix

Quixin

Reskuin

R-Ofloxacin

RWJ 25213-097

RWJ-25213

S-(-)-Ofloxacin

S1940_Selleck

SAM001246758

SMR000466387

SPBio_001891

Spectrum_001719

SPECTRUM1504260

Spectrum2_001676

Spectrum3_000995

Spectrum4_001123

Spectrum5_001438

Tavanic

Volequin

Ofloxacin

Approved

Not Applicable

82419-36-1

4583

Synonyms:

( -)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)(1,4)benzoxazin-6-carbonsaeure

(+-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid

(+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperaz inyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid

(+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7- -oxo-7H-pyrido(1,2,3-de)- -1,4-benzoxazine-6-carboxylic acid

(+/-)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

(+/-)-Floxin

118120-51-7 (hydrochloride)

33703_FLUKA

33703_RIEDEL

82419-36-1

83380-47-6

85344-55-4

8-fluoro-3-Methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylate

8-fluoro-3-Methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid

8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid

9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

AB00513820

AC1L1IHM

AC-7616

AKOS001033517

Bactocin

BB_SC-1252

BPBio1_000345

BRD-A24228527-001-05-9

BRN 3657947

BSPBio_000313

BSPBio_003117

C07321

C18H20FN3O4

CCRIS 5233

CHEBI:7731

CHEMBL4

CID4583

CPD000058192

D00453

Danoflox

DB01165

DEXTROFLOXACINE

DivK1c_000721

DL 8280

DL-8280

DL-8280, HOE-280, Exocin, Flobacin, Floxin, Floxil, Monoflocet, Ofloxacin

Effexin

EU-0100904

Exocin

Exocine

Flobacin

Flodemex

Flotavid

Flovid

Floxal

Floxil

Floxin

Floxin (TN)

FLOXIN IN DEXTROSE 5%

FLOXIN IN DEXTROSE 5% IN PLASTIC CONTAINER

Floxin otic

Floxstat

Fugacin

HMS1568P15

HMS1921H12

HMS2090F07

HMS2092B10

HMS502E03

Hoe 280

HOE 280

Hoe-280

I06-0112

I06-0380

IDI1_000721

Inoflox

KBio1_000721

KBio2_001666

KBio2_004234

KBio2_006802

KBio3_002617

KBioGR_000667

KBioSS_001666

Kinflocin

Kinoxacin

Liflox

Lopac0_000904

Loxinter

LS-133259

Marfloxacin

Medofloxine

Mergexin

MLS000028749

MLS001074203

MolPort-000-422-241

MolPort-000-873-068

NCGC00015772-02

NCGC00015772-10

NCGC00094219-01

NCGC00094219-02

NCGC00094219-03

NCGC00094219-04

NCGC00094219-05

NCGC00094219-06

NCGC00178284-01

NCGC00178284-02

NINDS_000721

Novecin

NSC727071

Nufafloqo

O 8757

O8757_SIGMA

Obide

Occidal

Ocuflox

Ofcin

Oflin

Oflocee

Oflocet

Oflocin

Oflodal

Oflodex

Oflodura

Oflox

O-Flox

ofloxacin

Ofloxacin (JP15/USP/INN)

Ofloxacin [USAN:BAN:INN:JAN]

Ofloxacin hydrochloride

Ofloxacin Otic

Ofloxacin, (S)-Isomer

Ofloxacina

Ofloxacina [DCIT]

Ofloxacine

Ofloxacine [French]

Ofloxacino

Ofloxacino [Spanish]

Ofloxacinum

Ofloxacinum [Latin]

Ofloxin

OFLX

Ofus

OFX

Onexacin

Operan

Oprea1_242882

ORF 18489

ORF-28489

Orocin

Otonil

Oxaldin

Pharflox

Praxin

Prestwick0_000237

Prestwick1_000237

Prestwick2_000237

Prestwick3_000237

PT 01

Puiritol

Qinolon

Qipro

Quinolon

Quotavil

Rilox

Ru-43280

S1463_Selleck

SAM002264629

Sinflo

SMR000058192

SPBio_001387

SPBio_002234

Spectrum_001186

SPECTRUM1502044

Spectrum2_001464

Spectrum3_001499

Spectrum4_000324

Spectrum5_001063

STK256723

Tabrin

Taravid

Tariflox

Tarivid

Telbit

Tructum

UNII-A4P49JAZ9H

Uro Tarivid

Viotisone

Visiren

WP-0405

XED

Zanocin

Etanercept

Approved, Investigational

185243-69-0

Synonyms:

185243-69-0

CD120b

D00742

Enbrel

Enbrel (TN)

Enbrel Sureclick

etanercept

Etanercept

Etanercept (genetical recombination)

Etanercept (genetical recombination) (JAN)

Etanercept (USAN/INN)

Etanercept-szzs

p75

p80 TNF-alpha receptor

RHU TNFR:FC

RHU-TNFR:FC

TNF-R2

TNFR-Immunoadhesin

Tumor necrosis factor receptor 2

Tumor necrosis factor receptor superfamily member 1B precursor

Tumor necrosis factor receptor type II

Adalimumab

Approved

331731-18-1

16219006

Synonyms:

331731-18-1

Adalimumab

Adalimumab (genetical recombination)

Adalimumab (genetical recombination) (JAN)

Adalimumab (USAN/INN)

adalimumab-adaz

adalimumab-adbm

adalimumab-atto

D02597

Humira

Humira (TN)

Humira Pen

Ig gamma-1 chain C region

Rifaximin

Approved, Investigational

Not Applicable

80621-81-4

6436173

Synonyms:

(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate

4-deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin

4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin

4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV

80621-81-4

88747-56-2

AC-19112

alpha-0817185

Bio-0556

BRN 3584528

C43H51N3O11

CHEMBL1617

D02554

DB01220

Fatroximin

Flonorm

L 105

L 105 (Ansamacrolide antibiotic)

L 105SV

Lormyx

LS-178059

LS-64147

Lumenax

MLS000759430

Normix

Redactiv

RedActiv

Rifacol

Rifamixin

Rifamycin L 105

Rifamycin L 105SV

Rifaxidin

Rifaximin

Rifaximin (USAN/INN)

Rifaximin [USAN:INN]

Rifaximina

Rifaximina [Spanish]

Rifaximine

Rifaximine [French]

Rifaximinum

Rifaximinum [Latin]

Rifaximinun

Rifaxin

Ritacol

S1790_Selleck

SMR000466324

Spiraxin

UNII-L36O5T016N

Xifaxan

Xifaxan, Rifacol, Fatroximin, Rifaximin

Xifaxsan

Xifaxsan (TN)

Anti-Infective Agents, Urinary

Not Applicable

Cytochrome P-450 Enzyme Inhibitors

Not Applicable

Renal Agents

Not Applicable

Topoisomerase Inhibitors

Not Applicable

Cytochrome P-450 CYP1A2 Inhibitors

Not Applicable

Cola

Anti-Inflammatory Agents

Anti-Inflammatory Agents, Non-Steroidal

rifamycin SV

Not Applicable

Rifamycins

Not Applicable

Interventional clinical trials:

(show all 16)

#	Name	Status	NCT ID	Phase	Drugs
1	Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria	Completed	NCT00351273	Phase 3	Doxycycline and Rifampin;Azithromycin and Rifampin;Placebo
2	Mechanism of Action of Anti-IL17 Therapy in Peripheral Spondyloarthritis	Completed	NCT03358134	Phase 3	Secukinumab
3	New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis	Unknown status	NCT00244179	Phase 2	interferon-gamma;infliximab;dmard
4	Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children	Completed	NCT00502593	Phase 2
5	Safety Study of Inactivated Shigella Whole Cell Vaccine in Adults	Completed	NCT01509846	Phase 1
6	Study of Long-Term Antibiotic Treatment in Reactive Arthritis	Completed	NCT00621387	Not Applicable	ofloxacin and roxithromycin;placebo
7	Late Cardial Assessment in Children Who Were Diagnosed With Post Streptococcal Reactive Arthritis - a Long Term Study	Completed	NCT01179451
8	Longitudinal ULtrasonographic Study of Patients With Spondylarthritis Starting Biological Therapy	Completed	NCT01219257
9	The Pathogenesis of Inflammatory Synovitis: A Study of Early Arthritis	Completed	NCT00001375
10	The Characterization of Small Bowel and Colonic Involvement in Patients With Seronegative Spondyloarthritides	Completed	NCT00768950
11	Safety Study of Live Shigella Vaccine in Bangladeshi Adults and Children	Completed	NCT01813071	Not Applicable
12	Prognostic Indicators and Determinants of the 2-5 Year Outcome in a Cohort of Early Synovitis Patients	Completed	NCT00001679
13	Trial Evaluating Chemoprophylaxis Against Travelers' Diarrhea - Prevent TD	Recruiting	NCT02498301	Not Applicable	Rifaximin;Placebo
14	Value of Tomosynthesis for the Detection of Sacro-iliitis (TOMOS SI)	Recruiting	NCT03689881	Not Applicable
15	Diagnostic Value of DECT Scan Compared to Diagnostic Needle Aspiration	Recruiting	NCT03038386	Not Applicable
16	Rheumatological Manifestations in Inflammatory Bowel Diseases	Not yet recruiting	NCT03486652

Search NIH Clinical Center for Reactive Arthritis

Cochrane evidence based reviews: arthritis, reactive

Sources

Genetic Tests for Reactive Arthritis

Sources

Anatomical Context for Reactive Arthritis

MalaCards organs/tissues related to Reactive Arthritis:

⁴¹

T Cells, Eye, Bone, B Cells, Heart, Myeloid, Lung

Sources

Publications for Reactive Arthritis

Articles related to Reactive Arthritis:

(show top 50) (show all 922)

#	Title	Authors	Year
1	Chronic reactive arthritis associated with prostatitis caused by<i>Neisseria meningitidis</i>. ( 29374652 )	Kawahara K....Morita Y.	2018
2	Hypertrophic osteoarthropathy mimicking a reactive arthritis: a case report and review of the literature. ( 29759083 )	Bozzao F....Fischetti F.	2018
3	<i>Clostridium difficile</i> Colitis Leading to Reactive Arthritis: A Rare Complication Associated With a Common Disease. ( 29623279 )	Marwat A....Joshi M.	2018
4	Disease-association of different killer cell immunoglobulin-like receptors (KIR) and HLA-C gene combinations in reactive arthritis. ( 29848119 )	Sun H.S....Hu N.W.	2018
5	Reactive arthritis: update 2018. ( 29455267 )	GarcA-a-Kutzbach A....Iraheta I.	2018
6	Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis. ( 29073348 )		2018
7	Potential risk factors for reactive arthritis and persistence of symptoms at 2A years: a case-control study with longitudinal follow-up. ( 29139030 )		2018
8	Poststreptococcal reactive arthritis in Japan. ( 29606414 )		2018
9	IL-12/23p40 overproduction by dendritic cells leads to an increased Th1 and Th17 polarization in a model of Yersinia enterocolitica-induced reactive arthritis in TNFRp55-/- mice. ( 29494692 )		2018
10	Metabolite assignment of ultrafiltered synovial fluid extracted from knee joints of reactive arthritis patients using high resolution NMR spectroscopy. ( 29907975 )		2018
11	Reactive arthritis caused by Haemophilus parainfluenzae in a diabetic patient. ( 30503876 )	Eguchi T...Terada Y	2018
12	NMR-Based Serum Metabolomics Revealed Distinctive Metabolic Patterns in Reactive Arthritis Compared with Rheumatoid Arthritis. ( 30376345 )	Dubey D...Kumar D	2018
13	A case report of TB versus idiopathic granulomatous mastitis with erythema nodosum, reactive arthritis, cough, and headache. ( 30293476 )	Ben Abid F...Abdel Rahman S Al Soub H	2018
14	Ultrasonographic findings in a patient with reactive arthritis induced by intravesical BCG therapy for bladder cancer. ( 29992394 )	Yoshimura H...Nakamura H	2018
15	Case: Bacillus Calmette-Guerin (BCG)-induced Reiter syndrome with an attempt at repeat BCG induction. ( 29173272 )	Cheung DC...Hamilton RJ	2018
16	Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing I^I'T Cells. ( 28944217 )	Noto Llana M....Cerquetti M.C.	2017
17	Human Leukocyte Antigen-B27: The Genetic Predisposition Leading to Reactive Arthritis during Induction Phase Chemotherapy for Acute Myeloid Leukemia. ( 29200696 )	Bartakke S.P....Patel P.	2017
18	Yersinia enterocolitica biotype 1A: a possible new trigger of reactive arthritis. ( 28918489 )	Tuompo R....Leirisalo-Repo M.	2017
19	HLA-B27 Correlates with the Intracellular Elimination, Replication, and Trafficking of Salmonella Enteritidis Collected from Reactive Arthritis Patients. ( 29135969 )	Zhao Y....Liu Y.	2017
20	The Case of Reactive Arthritis Secondary to Echinococcus Infestation. ( 28607793 )	AlA+m B....BingAPl M.O.	2017
21	Strongly positive anti-CCP antibodies in patients with sacroiliitis or reactive arthritis post-E.A coli infection: A mini case-series based review. ( 28589668 )	Singh Sangha M....Ciurtin C.	2017
22	A retrospective study: Acute rheumatic fever and post-streptococcal reactive arthritis in Japan. ( 28442182 )	Sato S....Kawano Y.	2017
23	Reactive Arthritis. ( 28292540 )	Schmitt S.K.	2017
24	Reactive Arthritis Caused by Yersinia enterocolitica Enteritis. ( 28502944 )	Honda K....Migita K.	2017
25	A case of reactive arthritis secondary to sexually acquired <i>Shigella flexneri</i>. ( 29744120 )	Kennedy S.L....Wenham C.Y.	2017
26	Chlamydia trachomatis-induced reactive arthritis in India: frequency and clinical presentation. ( 28576785 )	Kumar P....Rastogi S.	2017
27	Epidemiology: Time to revisit the concept of reactive arthritis. ( 28490789 )	Misra R....Gupta L.	2017
28	Understanding TMJ reactive arthritis. ( 28760073 )		2017
29	A bicentre retrospective study of features and outcomes of patients with reactive arthritis. ( 28238883 )		2017
30	Reactive arthritis associated with<i>Strongyloides stercoralis</i>: Report of an uncommon relation. ( 29114491 )		2017
31	Streptococcal tonsillitis related reactive arthritis - clinical, ultrasound imaging and immunohistochemical study. ( 29250657 )		2017
32	Prevalence of Chlamydia-associated reactive arthritis. ( 28067600 )		2017
33	Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis. ( 28496443 )		2017
34	Bilateral interstitial keratitis with anterior stromal infiltrates associated with reactive arthritis. ( 28687682 )	Hsing YE...Walker J	2017
35	IL-17 and IFN-γ producing NK and γδ-T cells are preferentially expanded in synovial fluid of patients with reactive arthritis and undifferentiated spondyloarthritis. ( 28390966 )	Chowdhury AC...Misra R	2017
36	A Case of Reactive Arthritis Associated With Lymphogranuloma Venereum Infection in a Woman. ( 27513386 )	Foschi C....Marangoni A.	2016
37	Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research. ( 27681924 )	Zeidler H....Hudson A.P.	2016
38	Early treatment of reactive arthritis with etanercept and 2 years follow-up. ( 27269651 )	Courcoul A....Coury F.	2016
39	Association between Giardia and arthritis or joint pain in a large health insurance cohort: could it be reactive arthritis? ( 27640995 )	Painter J.E....Gargano J.W.	2016
40	The incidence of sexually acquired reactive arthritis: a systematic literature review. ( 27480977 )	Denison H.J....Grainger R.	2016
41	Frequency of reactive arthritis, uveitis, and conjunctivitis in Japanese patients with bladder cancer following intravesical BCG therapy: A 20-year, two-centre retrospective study. ( 27825571 )	Taniguchi Y....Terada Y.	2016
42	Clostridium difficile Enterocolitis and Reactive Arthritis: A Case Report and Review of the Literature. ( 27190666 )	Cappella M....Marchetti F.	2016
43	Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis. ( 27977029 )	Lyons C.J....Gardiner J.	2016
44	Recent advances and future directions in understanding and treating Chlamydia-induced reactive arthritis. ( 27627462 )	Carter J.D....Hudson A.P.	2016
45	Reactive Arthritis Caused by Urinary Tract Infection. ( 27150879 )	Nishizaki Y....Daida H.	2016
46	Recombinant Salmonella typhimurium Outer membrane protein A is recognized by synovial fluid CD8 cells and stimulates synovial fluid mononuclear cells to produce IL17/IL23 in patients with Reactive arthritis and undifferentiated spondyloarthropathy. ( 27060348 )	Chaurasia S....Misra R.	2016
47	Anti-TNF treatment of reactive arthritis. A monocentric experience. ( 27236263 )	Brinster A....Wendling D.	2016
48	Reactive arthritis following a Microsporidia infection. ( 27020082 )	Mason E....Donovan B.	2016
49	Microbe-triggered arthropathies: reactive arthritis and beyond. ( 27232885 )	Gupta R....Misra R.	2016
50	A case of reactive arthritis due to Clostridium difficile colitis. ( 26908381 )		2016

Sources

Genes for Reactive Arthritis

Genes related to Reactive Arthritis (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	36.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7905462 8608642 9328119 (more) 10640771 7693941
2	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	35.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications (show sections)	9131588
3	BPI	Bactericidal Permeability Increasing Protein	Protein Coding	25.78	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11028843
4	MMP8	Matrix Metallopeptidase 8	Protein Coding	23.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7923879 8192476
5	HP	Haptoglobin	Protein Coding	23.13	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	1706901
6	OMP	Olfactory Marker Protein	Protein Coding	22.17	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	12021151
7	TNF	Tumor Necrosis Factor	Protein Coding	22.12	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	IFNG	Interferon Gamma	Protein Coding	22.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	CRP	C-Reactive Protein	Protein Coding	21.87	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	16485108 7562749 1384103 (more) 19762363 8624640 16513489
10	TRH	Thyrotropin Releasing Hormone	Protein Coding	21.41	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	7858584 8763085 7971809
11	COMP	Cartilage Oligomeric Matrix Protein	Protein Coding	21.28	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	16485108 15059267 17894003
12	IL10	Interleukin 10	Protein Coding	21.28	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	IL17A	Interleukin 17A	Protein Coding	21.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Reactive Arthritis

Sources

Expression for Reactive Arthritis

Search GEO for disease gene expression data for Reactive Arthritis.

Sources

Pathways for Reactive Arthritis

Pathways related to Reactive Arthritis according to GeneCards Suite gene sharing:

(show all 24)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.81	BPI CRP HLA-B HP IFNG IL10
2	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.47	HLA-B HSPD1 IFNG IL10 IL17A TNF
3	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.41	IFNG IL10 IL17A TNF
4	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.4	IFNG IL10 IL17A TNF
5	NF-kappaB Signaling ⁴	12.36	IFNG IL10 IL17A TNF
6	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.2	IFNG IL10 IL17A TNF
7	Tuberculosis ³⁷	12.03	HSPD1 IFNG IL10 TNF
8	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	12.01	HLA-B IFNG IL10 IL17A TNF
9	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12	HSPD1 IL10 TNF
10	Microglia Activation During Neuroinflammation: Overview ⁶⁵ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁵	11.87	HSPD1 IFNG TNF
11	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.83	IFNG IL10 TNF
12	Interleukin-4 and 13 signaling ⁶⁶	11.82	IL10 IL17A TNF
13	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	11.78	IFNG IL10 IL17A TNF
14	Amoebiasis ³⁷	11.69	IFNG IL10 TNF
15	Rheumatoid arthritis ³⁷	11.65	IFNG IL17A TNF
16	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.56	IFNG IL10 TNF
17	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.36	IFNG IL10 IL17A TNF
18	African trypanosomiasis ³⁷	11.18	IFNG IL10 TNF
19	Development and heterogeneity of the ILC family ¹	11.11	IFNG IL17A TNF
20	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁵	11.11	IFNG IL10 IL17A TNF
21	OX40 Pathway ⁶⁴	11.03	IFNG IL10
22	Cytokines and Inflammatory Response ¹	10.96	IFNG IL10 TNF
23	Overview of nanoparticle effects ¹	10.88	CRP TNF
24	Malaria ³⁷	10.61	COMP IFNG IL10 TNF

Sources

GO Terms for Reactive Arthritis

Cellular components related to Reactive Arthritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.65	BPI COMP CRP HP IFNG IL10
2	specific granule lumen	GO:0035580	9.33	BPI HP MMP8
3	extracellular space	GO:0005615	9.32	BPI COMP CRP HP HSPD1 IFNG

Biological processes related to Reactive Arthritis according to GeneCards Suite gene sharing:

(show all 31)

#	Name	GO ID	Score	Top Affiliating Genes
1	neutrophil degranulation	GO:0043312	9.95	BPI HLA-B HP MMP8
2	positive regulation of gene expression	GO:0010628	9.93	CRP IFNG MMP8 TNF
3	inflammatory response	GO:0006954	9.92	CRP IL10 IL17A TNF
4	regulation of signaling receptor activity	GO:0010469	9.88	IFNG IL10 IL17A TNF TRH
5	defense response to bacterium	GO:0042742	9.87	BPI HP IL10 TNF
6	response to glucocorticoid	GO:0051384	9.72	HSPD1 IL10 TNF
7	positive regulation of interleukin-6 production	GO:0032755	9.69	HSPD1 MMP8 TNF
8	positive regulation of interleukin-12 production	GO:0032735	9.65	HSPD1 IFNG
9	positive regulation of interleukin-6 secretion	GO:2000778	9.64	HSPD1 IL17A
10	positive regulation of protein complex assembly	GO:0031334	9.64	IFNG TNF
11	protein import into nucleus, translocation	GO:0000060	9.63	IFNG TNF
12	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.63	IFNG MMP8 TNF
13	positive regulation of macrophage activation	GO:0043032	9.62	HSPD1 IL10
14	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.61	IFNG TNF
15	negative regulation of growth of symbiont in host	GO:0044130	9.61	IL10 TNF
16	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.6	IL10 TNF
17	positive regulation of tumor necrosis factor secretion	GO:1904469	9.59	HSPD1 MMP8
18	negative regulation of lipid storage	GO:0010888	9.58	CRP TNF
19	endothelial cell apoptotic process	GO:0072577	9.58	IL10 TNF
20	negative regulation of interleukin-8 production	GO:0032717	9.56	BPI IL10
21	negative regulation of cytokine secretion involved in immune response	GO:0002740	9.54	IL10 TNF
22	positive regulation of neuroinflammatory response	GO:0150078	9.52	MMP8 TNF
23	positive regulation of interleukin-23 production	GO:0032747	9.49	IFNG IL17A
24	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.43	IFNG TNF
25	negative regulation of interleukin-6 production	GO:0032715	9.43	BPI IL10 TNF
26	receptor biosynthetic process	GO:0032800	9.4	IL10 TNF
27	regulation of microglial cell activation	GO:1903978	9.37	MMP8 TNF
28	positive regulation of osteoclast differentiation	GO:0045672	9.33	IFNG IL17A TNF
29	positive regulation of vitamin D biosynthetic process	GO:0060557	9.32	IFNG TNF
30	response to organic substance	GO:0010033	9.26	HP HSPD1 IL10 TNF
31	immune response	GO:0006955	9.1	BPI HLA-B IFNG IL10 IL17A TNF

Molecular functions related to Reactive Arthritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protease binding	GO:0002020	9.13	COMP HSPD1 TNF
2	cytokine activity	GO:0005125	8.92	IFNG IL10 IL17A TNF

Sources

Sources for Reactive Arthritis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Reactive Arthritis (PIRA)

Aliases & Classifications for Reactive Arthritis

MalaCards integrated aliases for Reactive Arthritis:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for Reactive Arthritis

Related Diseases for Reactive Arthritis

Diseases related to Reactive Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Reactive Arthritis:

Symptoms & Phenotypes for Reactive Arthritis

Human phenotypes related to Reactive Arthritis:

MGI Mouse Phenotypes related to Reactive Arthritis:

Drugs & Therapeutics for Reactive Arthritis

Drugs for Reactive Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Cochrane evidence based reviews: arthritis, reactive

Genetic Tests for Reactive Arthritis

Anatomical Context for Reactive Arthritis

MalaCards organs/tissues related to Reactive Arthritis:

Publications for Reactive Arthritis

Articles related to Reactive Arthritis:

Genes for Reactive Arthritis

Genes related to Reactive Arthritis (0 elite genes):

Variations for Reactive Arthritis

Expression for Reactive Arthritis

Pathways for Reactive Arthritis

Pathways related to Reactive Arthritis according to GeneCards Suite gene sharing:

GO Terms for Reactive Arthritis

Cellular components related to Reactive Arthritis according to GeneCards Suite gene sharing:

Biological processes related to Reactive Arthritis according to GeneCards Suite gene sharing:

Molecular functions related to Reactive Arthritis according to GeneCards Suite gene sharing:

Sources for Reactive Arthritis