PIRA
MCID: RCT015
MIFTS: 64

Reactive Arthritis (PIRA)

Categories: Bone diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Reactive Arthritis

MalaCards integrated aliases for Reactive Arthritis:

Name: Reactive Arthritis 12 76 53 59 15
Reiter Syndrome 53 59 73
Arthritis, Reactive 44 73
Reiter Disease 12 59
Post-Infectious Reactive Arthropathy 53
Fiessinger Leroy Reiter Syndrome 12
Fiessinger-Leroy-Reiter Syndrome 59
Post-Dysenteric Arthropathy 73
Post-Bacterial Arthropathy 12
Postdysenteric Arthropathy 12
Post-Infectious Arthritis 53
Fiessinger-Leroy Disease 59
Polyarthritis Enterica 59
Arthritis Urethritica 59
Arthritis, Venereal 73
Venereal Arthritis 59
Arthritis Reactive 55
Reiter's Syndrome 53
Reiter's Disease 12
Reiters Syndrome 55
Pira 53

Characteristics:

Orphanet epidemiological data:

59
reactive arthritis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



Summaries for Reactive Arthritis

NIH Rare Diseases : 53 Reactive arthritis is a type of infectious arthritis that occurs as a �??reaction�?� to an infection elsewhere in the body. This process may occur weeks or even months after the infection has resolved. In addition to joint inflammation, reactive arthritis is associated with two other symptoms: redness and inflammation of the eyes (conjunctivitis) and inflammation of the urinary tract (urethritis). These symptoms may occur alone, together, or not at all. The symptoms of reactive arthritis usually last 3 to 12 months, although symptoms can return or develop into a long-term disease in a small percentage of people. The exact cause of reactive arthritis is unknown. It may follow an infection with Salmonella enteritidis, Salmonella typhimurium, Yersinia enterocolitica, Campylobacter jejuni, Clostridium difficile, Shigella sonnei, Entamoeba histolytica, Cryptosporidium, or Chlamydia trachomatis. Certain genes may make you more prone to the syndrome. For instance, the condition is observed more commonly in patients with human lymphocyte antigen B27 (HLA-B27) histocompatibility antigens. The goal of treatment is to relieve symptoms and treat any underlying infection. Antibiotics may be prescribed. Nonsteroidal anti-inflammatory drugs (NSAIDS), pain relievers, and corticosteroids may be recommended for those with joint pain. 

MalaCards based summary : Reactive Arthritis, also known as reiter syndrome, is related to spondyloarthropathy 1 and arthritis. An important gene associated with Reactive Arthritis is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include t cells, eye and bone, and related phenotypes are respiratory insufficiency and arthritis

Disease Ontology : 12 An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body.

Wikipedia : 76 Reactive arthritis, formerly known as Reiter''s syndrome, is a form of inflammatory arthritis that... more...

Related Diseases for Reactive Arthritis

Diseases related to Reactive Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 308)
# Related Disease Score Top Affiliating Genes
1 spondyloarthropathy 1 32.8 CRP HLA-B IL17A TNF
2 arthritis 31.5 IFNG IL10 IL17A TNF
3 spondylitis 30.3 CRP HLA-B IL17A TNF
4 chlamydia 30.2 CRP HSPD1 IFNG IL10 TNF
5 rheumatic fever 30.0 HP IL10 TNF
6 colitis 29.9 IFNG IL10 IL17A TNF
7 spondyloarthropathy 29.9 HLA-B IFNG IL10 IL17A TNF
8 uveitis 29.8 HLA-B IFNG IL10 IL17A TNF
9 anterior uveitis 29.8 HLA-B TNF
10 gastroenteritis 29.7 CRP IL10 TNF
11 multifocal choroiditis 29.7 IL10 TNF
12 choroiditis 29.7 IL10 TNF
13 haemophilus influenzae 29.7 OMP TNF
14 toxic shock syndrome 29.6 IFNG IL10 TNF
15 viral infectious disease 29.6 IFNG IL10 TNF
16 cat-scratch disease 29.6 HSPD1 IFNG
17 vasculitis 29.5 BPI CRP HLA-B TNF
18 rheumatoid arthritis 29.4 COMP CRP HLA-B IFNG IL10 IL17A
19 rheumatic heart disease 29.4 HLA-B IL10 TNF
20 tenosynovitis 29.4 COMP CRP
21 synovitis 29.4 COMP CRP TNF
22 human immunodeficiency virus infectious disease 29.4 IFNG IL10 TNF
23 pneumonia 29.4 CRP IL10 TNF
24 psoriatic arthritis 29.4 COMP CRP HLA-B IL17A TNF
25 arthropathy 29.4 COMP CRP TNF
26 osteomyelitis 29.4 IFNG IL10 TNF
27 kawasaki disease 29.2 CRP HSPD1 IL10 TNF
28 brucellosis 29.2 CRP IFNG IL10 TNF
29 peritonitis 29.1 CRP IL10 TNF
30 systemic lupus erythematosus 29.1 CRP IFNG IL10 IL17A TNF
31 meningitis 29.0 CRP IFNG IL10 OMP TNF
32 psoriasis 29.0 IFNG IL10 IL17A TNF
33 leptospirosis 29.0 CRP IFNG IL10 TNF
34 inflammatory bowel disease 28.9 BPI CRP HLA-B IFNG IL10 IL17A
35 appendicitis 28.9 CRP IL10 MMP8 TNF
36 bacterial meningitis 28.9 CRP IL10 MMP8 TNF
37 rheumatic disease 28.8 CRP HLA-B IFNG IL10 TNF
38 septic arthritis 11.8
39 shigellosis 11.1
40 idiopathic bronchiectasis 10.3 HLA-B IFNG
41 asymptomatic neurosyphilis 10.3 IFNG IL17A
42 myositis fibrosa 10.3 IFNG IL17A
43 nontuberculous mycobacterial lung disease 10.2 HLA-B TNF
44 rheumatoid lung disease 10.2 IL17A TNF
45 crohn's colitis 10.2 IFNG TNF
46 meconium aspiration syndrome 10.2 IFNG TNF
47 cardiac sarcoidosis 10.2 IFNG TNF
48 scleritis 10.2 IFNG TNF
49 miliary tuberculosis 10.2 IFNG TNF
50 soft tissue sarcoma 10.2 IFNG TNF

Graphical network of the top 20 diseases related to Reactive Arthritis:



Diseases related to Reactive Arthritis

Symptoms & Phenotypes for Reactive Arthritis

Human phenotypes related to Reactive Arthritis:

59 32 (show all 26)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 respiratory insufficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0002093
2 arthritis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001369
3 joint stiffness 59 32 hallmark (90%) Very frequent (99-80%) HP:0001387
4 cognitive impairment 59 32 hallmark (90%) Very frequent (99-80%) HP:0100543
5 photophobia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000613
6 fever 59 32 occasional (7.5%) Occasional (29-5%) HP:0001945
7 joint swelling 59 32 hallmark (90%) Very frequent (99-80%) HP:0001386
8 pulmonary fibrosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002206
9 arthralgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002829
10 abdominal pain 59 32 frequent (33%) Frequent (79-30%) HP:0002027
11 hyperkeratosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000962
12 weight loss 59 32 occasional (7.5%) Occasional (29-5%) HP:0001824
13 abnormality of the pleura 59 32 frequent (33%) Frequent (79-30%) HP:0002103
14 inflammation of the large intestine 59 32 frequent (33%) Frequent (79-30%) HP:0002037
15 osteomyelitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002754
16 diarrhea 59 32 hallmark (90%) Very frequent (99-80%) HP:0002014
17 pericarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001701
18 conjunctivitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000509
19 recurrent urinary tract infections 59 32 occasional (7.5%) Occasional (29-5%) HP:0000010
20 cartilage destruction 59 32 hallmark (90%) Very frequent (99-80%) HP:0100773
21 dystrophic fingernails 59 32 hallmark (90%) Very frequent (99-80%) HP:0008391
22 aortic regurgitation 59 32 occasional (7.5%) Occasional (29-5%) HP:0001659
23 recurrent aphthous stomatitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0011107
24 pustule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200039
25 enthesitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100686
26 abnormality of the nail 59 Very frequent (99-80%)

MGI Mouse Phenotypes related to Reactive Arthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.85 COMP CRP HP IFNG IL10 IL17A
2 immune system MP:0005387 9.56 COMP CRP HP IFNG IL10 IL17A
3 no phenotypic analysis MP:0003012 9.1 IFNG IL10 IL17A OMP TNF TRH

Drugs & Therapeutics for Reactive Arthritis

Drugs for Reactive Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 3 83905-01-5 55185 447043
2
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
3
Rifampicin Approved Phase 3 13292-46-1 5458213 5381226
4 Antibiotics, Antitubercular Phase 3,Phase 2,Not Applicable
5 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
6 Anti-Bacterial Agents Phase 3,Phase 2,Not Applicable
7 Nucleic Acid Synthesis Inhibitors Phase 3,Not Applicable
8 Antiprotozoal Agents Phase 3
9 Cytochrome P-450 CYP3A Inducers Phase 3
10 Antiparasitic Agents Phase 3
11 Antitubercular Agents Phase 3
12 Antimalarials Phase 3
13
Infliximab Approved Phase 2 170277-31-3
14 Antiviral Agents Phase 2
15 Interferon-gamma Phase 2
16 interferons Phase 2
17 Dermatologic Agents Phase 2
18 Antirheumatic Agents Phase 2
19 Gastrointestinal Agents Phase 2,Not Applicable
20 Vaccines Phase 2,Phase 1,Not Applicable
21 Immunologic Factors Phase 2,Phase 1
22
Levofloxacin Approved, Investigational Not Applicable 100986-85-4 149096
23
Ofloxacin Approved Not Applicable 82419-36-1 4583
24
Etanercept Approved, Investigational 185243-69-0
25
Adalimumab Approved 331731-18-1 16219006
26
Rifaximin Approved, Investigational Not Applicable 80621-81-4 6436173
27 Anti-Infective Agents, Urinary Not Applicable
28 Cytochrome P-450 Enzyme Inhibitors Not Applicable
29 Renal Agents Not Applicable
30 Topoisomerase Inhibitors Not Applicable
31 Cytochrome P-450 CYP1A2 Inhibitors Not Applicable
32 Cola
33 Anti-Inflammatory Agents
34 Anti-Inflammatory Agents, Non-Steroidal
35 rifamycin SV Not Applicable
36 Rifamycins Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria Completed NCT00351273 Phase 3 Doxycycline and Rifampin;Azithromycin and Rifampin;Placebo
2 Mechanism of Action of Anti-IL17 Therapy in Peripheral Spondyloarthritis Completed NCT03358134 Phase 3 Secukinumab
3 New Immunomodulatory Therapy Strategies in Chronic Reactive Arthritis Unknown status NCT00244179 Phase 2 interferon-gamma;infliximab;dmard
4 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
5 Safety Study of Inactivated Shigella Whole Cell Vaccine in Adults Completed NCT01509846 Phase 1
6 Study of Long-Term Antibiotic Treatment in Reactive Arthritis Completed NCT00621387 Not Applicable ofloxacin and roxithromycin;placebo
7 Late Cardial Assessment in Children Who Were Diagnosed With Post Streptococcal Reactive Arthritis - a Long Term Study Completed NCT01179451
8 Longitudinal ULtrasonographic Study of Patients With Spondylarthritis Starting Biological Therapy Completed NCT01219257
9 The Pathogenesis of Inflammatory Synovitis: A Study of Early Arthritis Completed NCT00001375
10 The Characterization of Small Bowel and Colonic Involvement in Patients With Seronegative Spondyloarthritides Completed NCT00768950
11 Safety Study of Live Shigella Vaccine in Bangladeshi Adults and Children Completed NCT01813071 Not Applicable
12 Prognostic Indicators and Determinants of the 2-5 Year Outcome in a Cohort of Early Synovitis Patients Completed NCT00001679
13 Trial Evaluating Chemoprophylaxis Against Travelers' Diarrhea - Prevent TD Recruiting NCT02498301 Not Applicable Rifaximin;Placebo
14 Value of Tomosynthesis for the Detection of Sacro-iliitis (TOMOS SI) Recruiting NCT03689881 Not Applicable
15 Diagnostic Value of DECT Scan Compared to Diagnostic Needle Aspiration Recruiting NCT03038386 Not Applicable
16 Rheumatological Manifestations in Inflammatory Bowel Diseases Not yet recruiting NCT03486652

Search NIH Clinical Center for Reactive Arthritis

Cochrane evidence based reviews: arthritis, reactive

Genetic Tests for Reactive Arthritis

Anatomical Context for Reactive Arthritis

MalaCards organs/tissues related to Reactive Arthritis:

41
T Cells, Eye, Bone, B Cells, Heart, Myeloid, Lung

Publications for Reactive Arthritis

Articles related to Reactive Arthritis:

(show top 50) (show all 922)
# Title Authors Year
1
Chronic reactive arthritis associated with prostatitis caused by<i>Neisseria meningitidis</i>. ( 29374652 )
2018
2
Hypertrophic osteoarthropathy mimicking a reactive arthritis: a case report and review of the literature. ( 29759083 )
2018
3
<i>Clostridium difficile</i> Colitis Leading to Reactive Arthritis: A Rare Complication Associated With a Common Disease. ( 29623279 )
2018
4
Disease-association of different killer cell immunoglobulin-like receptors (KIR) and HLA-C gene combinations in reactive arthritis. ( 29848119 )
2018
5
Reactive arthritis: update 2018. ( 29455267 )
2018
6
Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis. ( 29073348 )
2018
7
Potential risk factors for reactive arthritis and persistence of symptoms at 2A years: a case-control study with longitudinal follow-up. ( 29139030 )
2018
8
Poststreptococcal reactive arthritis in Japan. ( 29606414 )
2018
9
IL-12/23p40 overproduction by dendritic cells leads to an increased Th1 and Th17 polarization in a model of Yersinia enterocolitica-induced reactive arthritis in TNFRp55-/- mice. ( 29494692 )
2018
10
Metabolite assignment of ultrafiltered synovial fluid extracted from knee joints of reactive arthritis patients using high resolution NMR spectroscopy. ( 29907975 )
2018
11
Reactive arthritis caused by Haemophilus parainfluenzae in a diabetic patient. ( 30503876 )
2018
12
NMR-Based Serum Metabolomics Revealed Distinctive Metabolic Patterns in Reactive Arthritis Compared with Rheumatoid Arthritis. ( 30376345 )
2018
13
A case report of TB versus idiopathic granulomatous mastitis with erythema nodosum, reactive arthritis, cough, and headache. ( 30293476 )
2018
14
Ultrasonographic findings in a patient with reactive arthritis induced by intravesical BCG therapy for bladder cancer. ( 29992394 )
2018
15
Case: Bacillus Calmette-Guerin (BCG)-induced Reiter syndrome with an attempt at repeat BCG induction. ( 29173272 )
2018
16
Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing I^I'T Cells. ( 28944217 )
2017
17
Human Leukocyte Antigen-B27: The Genetic Predisposition Leading to Reactive Arthritis during Induction Phase Chemotherapy for Acute Myeloid Leukemia. ( 29200696 )
2017
18
Yersinia enterocolitica biotype 1A: a possible new trigger of reactive arthritis. ( 28918489 )
2017
19
HLA-B27 Correlates with the Intracellular Elimination, Replication, and Trafficking of Salmonella Enteritidis Collected from Reactive Arthritis Patients. ( 29135969 )
2017
20
The Case of Reactive Arthritis Secondary to Echinococcus Infestation. ( 28607793 )
2017
21
Strongly positive anti-CCP antibodies in patients with sacroiliitis or reactive arthritis post-E.A coli infection: A mini case-series based review. ( 28589668 )
2017
22
A retrospective study: Acute rheumatic fever and post-streptococcal reactive arthritis in Japan. ( 28442182 )
2017
23
Reactive Arthritis. ( 28292540 )
2017
24
Reactive Arthritis Caused by Yersinia enterocolitica Enteritis. ( 28502944 )
2017
25
A case of reactive arthritis secondary to sexually acquired <i>Shigella flexneri</i>. ( 29744120 )
2017
26
Chlamydia trachomatis-induced reactive arthritis in India: frequency and clinical presentation. ( 28576785 )
2017
27
Epidemiology: Time to revisit the concept of reactive arthritis. ( 28490789 )
2017
28
Understanding TMJ reactive arthritis. ( 28760073 )
2017
29
A bicentre retrospective study of features and outcomes of patients with reactive arthritis. ( 28238883 )
2017
30
Reactive arthritis associated with<i>Strongyloides stercoralis</i>: Report of an uncommon relation. ( 29114491 )
2017
31
Streptococcal tonsillitis related reactive arthritis - clinical, ultrasound imaging and immunohistochemical study. ( 29250657 )
2017
32
Prevalence of Chlamydia-associated reactive arthritis. ( 28067600 )
2017
33
Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis. ( 28496443 )
2017
34
Bilateral interstitial keratitis with anterior stromal infiltrates associated with reactive arthritis. ( 28687682 )
2017
35
IL-17 and IFN-γ producing NK and γδ-T cells are preferentially expanded in synovial fluid of patients with reactive arthritis and undifferentiated spondyloarthritis. ( 28390966 )
2017
36
A Case of Reactive Arthritis Associated With Lymphogranuloma Venereum Infection in a Woman. ( 27513386 )
2016
37
Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research. ( 27681924 )
2016
38
Early treatment of reactive arthritis with etanercept and 2 years follow-up. ( 27269651 )
2016
39
Association between Giardia and arthritis or joint pain in a large health insurance cohort: could it be reactive arthritis? ( 27640995 )
2016
40
The incidence of sexually acquired reactive arthritis: a systematic literature review. ( 27480977 )
2016
41
Frequency of reactive arthritis, uveitis, and conjunctivitis in Japanese patients with bladder cancer following intravesical BCG therapy: A 20-year, two-centre retrospective study. ( 27825571 )
2016
42
Clostridium difficile Enterocolitis and Reactive Arthritis: A Case Report and Review of the Literature. ( 27190666 )
2016
43
Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis. ( 27977029 )
2016
44
Recent advances and future directions in understanding and treating Chlamydia-induced reactive arthritis. ( 27627462 )
2016
45
Reactive Arthritis Caused by Urinary Tract Infection. ( 27150879 )
2016
46
Recombinant Salmonella typhimurium Outer membrane protein A is recognized by synovial fluid CD8 cells and stimulates synovial fluid mononuclear cells to produce IL17/IL23 in patients with Reactive arthritis and undifferentiated spondyloarthropathy. ( 27060348 )
2016
47
Anti-TNF treatment of reactive arthritis. A monocentric experience. ( 27236263 )
2016
48
Reactive arthritis following a Microsporidia infection. ( 27020082 )
2016
49
Microbe-triggered arthropathies: reactive arthritis and beyond. ( 27232885 )
2016
50
A case of reactive arthritis due to Clostridium difficile colitis. ( 26908381 )
2016

Variations for Reactive Arthritis

Expression for Reactive Arthritis

Search GEO for disease gene expression data for Reactive Arthritis.

Pathways for Reactive Arthritis

Pathways related to Reactive Arthritis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 BPI CRP HLA-B HP IFNG IL10
2
Show member pathways
12.47 HLA-B HSPD1 IFNG IL10 IL17A TNF
3
Show member pathways
12.41 IFNG IL10 IL17A TNF
4
Show member pathways
12.4 IFNG IL10 IL17A TNF
5 12.36 IFNG IL10 IL17A TNF
6
Show member pathways
12.2 IFNG IL10 IL17A TNF
7 12.03 HSPD1 IFNG IL10 TNF
8
Show member pathways
12.01 HLA-B IFNG IL10 IL17A TNF
9 12 HSPD1 IL10 TNF
10
Show member pathways
11.87 HSPD1 IFNG TNF
11 11.83 IFNG IL10 TNF
12 11.82 IL10 IL17A TNF
13
Show member pathways
11.78 IFNG IL10 IL17A TNF
14 11.69 IFNG IL10 TNF
15 11.65 IFNG IL17A TNF
16 11.56 IFNG IL10 TNF
17 11.36 IFNG IL10 IL17A TNF
18 11.18 IFNG IL10 TNF
19 11.11 IFNG IL17A TNF
20 11.11 IFNG IL10 IL17A TNF
21 11.03 IFNG IL10
22 10.96 IFNG IL10 TNF
23 10.88 CRP TNF
24 10.61 COMP IFNG IL10 TNF

GO Terms for Reactive Arthritis

Cellular components related to Reactive Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 BPI COMP CRP HP IFNG IL10
2 specific granule lumen GO:0035580 9.33 BPI HP MMP8
3 extracellular space GO:0005615 9.32 BPI COMP CRP HP HSPD1 IFNG

Biological processes related to Reactive Arthritis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.95 BPI HLA-B HP MMP8
2 positive regulation of gene expression GO:0010628 9.93 CRP IFNG MMP8 TNF
3 inflammatory response GO:0006954 9.92 CRP IL10 IL17A TNF
4 regulation of signaling receptor activity GO:0010469 9.88 IFNG IL10 IL17A TNF TRH
5 defense response to bacterium GO:0042742 9.87 BPI HP IL10 TNF
6 response to glucocorticoid GO:0051384 9.72 HSPD1 IL10 TNF
7 positive regulation of interleukin-6 production GO:0032755 9.69 HSPD1 MMP8 TNF
8 positive regulation of interleukin-12 production GO:0032735 9.65 HSPD1 IFNG
9 positive regulation of interleukin-6 secretion GO:2000778 9.64 HSPD1 IL17A
10 positive regulation of protein complex assembly GO:0031334 9.64 IFNG TNF
11 protein import into nucleus, translocation GO:0000060 9.63 IFNG TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 IFNG MMP8 TNF
13 positive regulation of macrophage activation GO:0043032 9.62 HSPD1 IL10
14 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IFNG TNF
15 negative regulation of growth of symbiont in host GO:0044130 9.61 IL10 TNF
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.6 IL10 TNF
17 positive regulation of tumor necrosis factor secretion GO:1904469 9.59 HSPD1 MMP8
18 negative regulation of lipid storage GO:0010888 9.58 CRP TNF
19 endothelial cell apoptotic process GO:0072577 9.58 IL10 TNF
20 negative regulation of interleukin-8 production GO:0032717 9.56 BPI IL10
21 negative regulation of cytokine secretion involved in immune response GO:0002740 9.54 IL10 TNF
22 positive regulation of neuroinflammatory response GO:0150078 9.52 MMP8 TNF
23 positive regulation of interleukin-23 production GO:0032747 9.49 IFNG IL17A
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG TNF
25 negative regulation of interleukin-6 production GO:0032715 9.43 BPI IL10 TNF
26 receptor biosynthetic process GO:0032800 9.4 IL10 TNF
27 regulation of microglial cell activation GO:1903978 9.37 MMP8 TNF
28 positive regulation of osteoclast differentiation GO:0045672 9.33 IFNG IL17A TNF
29 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
30 response to organic substance GO:0010033 9.26 HP HSPD1 IL10 TNF
31 immune response GO:0006955 9.1 BPI HLA-B IFNG IL10 IL17A TNF

Molecular functions related to Reactive Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.13 COMP HSPD1 TNF
2 cytokine activity GO:0005125 8.92 IFNG IL10 IL17A TNF

Sources for Reactive Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....