MCID: RCM006
MIFTS: 7

Recombination Rate Quantitative Trait Locus 1

Categories: Genetic diseases

Aliases & Classifications for Recombination Rate Quantitative Trait Locus 1

MalaCards integrated aliases for Recombination Rate Quantitative Trait Locus 1:

Name: Recombination Rate Quantitative Trait Locus 1 57 6 40
Recombination Rate Qtl 1 57 13
Rrqtl1 57

Classifications:



External Ids:

OMIM 57 612042

Summaries for Recombination Rate Quantitative Trait Locus 1

OMIM : 57 Recombination plays a crucial role in meiosis, ensuring the proper segregation of chromosomes. Linkage disequilibrium (LD) and sperm typing studies suggested that recombination rates vary tremendously across the human genome, with most events occurring in narrow hotspots (Coop et al., 2008). To examine variation in fine-scale recombination patterns among individuals, Coop et al. (2008) used dense genomewide nucleotide polymorphism data collected in nuclear families to localize crossovers with high spatial resolution. This analysis revealed that overall recombination hotspot usage is similar in males and females, with individual hotspots often active in both sexes. Across the genome, roughly 60% of crossovers occurred in hotspots inferred from LD studies (on chromosomes 17, 19, 10, and 11). Notably, however, Coop et al. (2008) found extensive and heritable variation among both males and females in the proportion of crossovers occurring in these hotspots. (612042)

MalaCards based summary : Recombination Rate Quantitative Trait Locus 1, is also known as recombination rate qtl 1. An important gene associated with Recombination Rate Quantitative Trait Locus 1 is RNF212 (Ring Finger Protein 212).

Related Diseases for Recombination Rate Quantitative Trait Locus 1

Symptoms & Phenotypes for Recombination Rate Quantitative Trait Locus 1

Clinical features from OMIM:

612042

Drugs & Therapeutics for Recombination Rate Quantitative Trait Locus 1

Search Clinical Trials , NIH Clinical Center for Recombination Rate Quantitative Trait Locus 1

Genetic Tests for Recombination Rate Quantitative Trait Locus 1

Anatomical Context for Recombination Rate Quantitative Trait Locus 1

Publications for Recombination Rate Quantitative Trait Locus 1

Variations for Recombination Rate Quantitative Trait Locus 1

Expression for Recombination Rate Quantitative Trait Locus 1

Search GEO for disease gene expression data for Recombination Rate Quantitative Trait Locus 1.

Pathways for Recombination Rate Quantitative Trait Locus 1

GO Terms for Recombination Rate Quantitative Trait Locus 1

Sources for Recombination Rate Quantitative Trait Locus 1

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