Aliases & Classifications for Rectal Disease

MalaCards integrated aliases for Rectal Disease:

Name: Rectal Disease 12 15 17
Rectal Diseases 44 70
Rectal Disorders 42


External Ids:

Disease Ontology 12 DOID:1285
MeSH 44 D012002
SNOMED-CT 67 5964004
UMLS 70 C0034882

Summaries for Rectal Disease

MedlinePlus : 42 The rectum is the lower part of your large intestine where your body stores stool. Problems with rectum are common. They include hemorrhoids, abscesses, incontinence and cancer. Many people are embarrassed to talk about rectal troubles. But seeing your doctor about problems in this area is important. This is especially true if you have pain or bleeding. Treatments vary depending on the particular problem. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Rectal Disease, also known as rectal diseases, is related to proctitis and hemorrhoid, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Rectal Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bupivacaine and Levobupivacaine have been mentioned in the context of this disorder. Affiliated tissues include colon, spinal cord and prostate, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 73 The rectum is the final straight portion of the large intestine in humans and some other mammals, and... more...

Related Diseases for Rectal Disease

Diseases related to Rectal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 914)
# Related Disease Score Top Affiliating Genes
1 proctitis 32.1 TNF KLK3 CRP CCR6
2 hemorrhoid 30.8 TNF KLK3 CRP
3 spinal cord injury 30.2 TNF IL6 CXCL8
4 pain agnosia 30.2 TNF IL6 IL1B
5 anus cancer 30.1 TP53 H2AC18 GP5 CDKN2A CD8A CD4
6 colonic disease 30.1 TP53 ICOSLG H2AC18 CCR6
7 diffuse large b-cell lymphoma 30.0 TP53 TNF IL6 IL10 CDKN2A
8 appendicitis 29.8 TNF IL6 IL2 IL1B IL10 CXCL8
9 crohn's disease 29.6 TNF IL6 IL2 IL1B IL10 ICOSLG
10 inflammatory bowel disease 29.2 TP53 TNF TLR8 IL6 IL2 IL1B
11 adult acute lymphocytic leukemia 10.6 CD8A CD4 CCR6
12 cork-handlers' disease 10.6 CD8A CD4
13 necrotic uveal melanoma 10.6 CD8A CD4
14 punctate inner choroidopathy 10.5 TNF IL10
15 external pathological resorption 10.5 TNF IL6
16 neurosyphilis 10.5 IL10 CXCL8
17 tropical endomyocardial fibrosis 10.5 TNF IL10
18 anal carcinoma in situ 10.5 TP53 CD4
19 scorpion envenomation 10.5 TNF IL6
20 type 1 diabetes mellitus 23 10.5 TNF CD8A CD4
21 early yaws 10.5 CD8A CD4
22 esophageal candidiasis 10.5 CD8A CD4 CCR6
23 west nile encephalitis 10.5 TLR7 CD8A CD4
24 granulomatous dermatitis 10.5 TNF CD8A CD4
25 autoimmune cholangitis 10.5 CD8A CD4 CCR6
26 uveoparotid fever 10.5 TNF CD8A CD4
27 drug reaction with eosinophilia and systemic symptoms 10.5 TNF CRP
28 pneumonic plague 10.5 TNF CD8A CD4
29 ventilation pneumonitis 10.5 CD8A CD4
30 retinal vasculitis 10.5 TNF CD4 CCR6
31 male urethral cancer 10.5 KLK3 CDKN2A
32 suppurative lymphadenitis 10.5 CRP CD4 CCR6
33 ulcerative stomatitis 10.5 TP53 CD8A CD4
34 oral hairy leukoplakia 10.5 IL10 CD8A CD4
35 blastomycosis 10.5 IL6 CD4 CCR6
36 histoplasmosis 10.5 TNF CD4 CCR6
37 keratoconjunctivitis sicca 10.5 TNF CD4 CCR6
38 epstein-barr virus-associated gastric carcinoma 10.5 TNF CDKN2A
39 goodpasture syndrome 10.5 H2AC18 CD4 CCR6
40 rheumatoid arthritis interstitial lung disease 10.5 TNF CRP CD4
41 parasitic ectoparasitic infectious disease 10.5 H2AC18 CD4 CCR6
42 penis squamous cell carcinoma 10.5 TP53 GP5 CD4
43 meningovascular neurosyphilis 10.5 TNF CRP CD4
44 swine influenza 10.5 TNF CD8A CD4
45 eyelid disease 10.5 TNF CD4 CCR6
46 opportunistic bacterial infectious disease 10.5 TNF CRP CD4
47 primary syphilis 10.5 CRP CD8A CD4
48 herpes simplex virus keratitis 10.5 CXCL8 CD4 CCR6
49 squamous cell papilloma 10.5 TP53 GP5 CDKN2A
50 nocardiosis 10.5 TNF CRP CD4

Graphical network of the top 20 diseases related to Rectal Disease:

Diseases related to Rectal Disease

Symptoms & Phenotypes for Rectal Disease

UMLS symptoms related to Rectal Disease:

nausea and vomiting; constipation; abdominal pain; diarrhea; dyspepsia; icterus; rectal tenesmus; heartburn; pruritus ani; gastrointestinal gas; rectal pain

GenomeRNAi Phenotypes related to Rectal Disease according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 CDKN2A CXCL8 IL10 IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 CDKN2A CXCL8 IL10 IL1B IL2 TNF
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.44 TP53

MGI Mouse Phenotypes related to Rectal Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 CCR6 CD4 CD8A CDKN2A IL10 IL1B
2 homeostasis/metabolism MP:0005376 10 CCR6 CD4 CDKN2A CRP GP5 IL10
3 immune system MP:0005387 9.77 CCR6 CD4 CD8A CDKN2A CRP IL10
4 neoplasm MP:0002006 9.17 CDKN2A IL10 IL1B IL2 IL6 TNF

Drugs & Therapeutics for Rectal Disease

Drugs for Rectal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
Acetaminophen Approved Phase 4 103-90-2 1983
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
tannic acid Approved Phase 4 1401-55-4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
Magnesium oxide Approved Phase 4 1309-48-4 14792
Magnesium hydroxide Approved, Investigational Phase 4 1309-42-8
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
Ibuprofen Approved Phase 4 15687-27-1 3672
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
15 Pharmaceutical Solutions Phase 4
16 Anesthetics, Local Phase 4
17 Polyethylene glycol 3350 Phase 4
18 Narcotics Phase 4
19 Anesthetics Phase 4
20 Cathartics Phase 4
21 Laxatives Phase 4
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 43805 6857599
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
24 Antioxidants Phase 2
25 Antimetabolites Phase 2
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4 445354
27 retinol
28 Retinol palmitate
29 Analgesics, Opioid

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Comparing the Effects of Levobupivacaine and Bupivacaine in Anorectal Surgery Under Saddle Spinal Anesthesia Completed NCT04245774 Phase 4 Levobupivacaine (as Levobupivacaine Hydrochloride) 75 Mg/10 mL Solution for Injection Ampoule;Bupivacaine/Dextrose
2 Prospective Randomized Controlled Trial of an Enhanced Recovery Protocol for Anorectal Surgery Recruiting NCT03738904 Phase 4
3 Is Greater Downstaging and Tumour Regression Observed When Surgery is Delayed to 12 Weeks After Completion of Chemoradiotherapy vs 6 Weeks? Unknown status NCT01037049 Phase 2
4 Evaluation of the Effect of the Ocoxin®-Viusid® Nutritional Supplement on the Quality of Life of Patients With Metastatic Colorectal Adenocarcinoma. Phase II Recruiting NCT03559543 Phase 2
5 An Open, Single Arm, Multicenter, Exploratory Phase II Clinical Trial of Anlotinib Hydrochloride Capsules Combined With CAPEOX in RAS and BRAF Wild-type Patients With Metastatic Colorectal Carcinoma as 1st Therapy Recruiting NCT04080843 Phase 2 Anlotinib Hydrochloride;Capecitabine;Oxaliplatin
6 Water Injection Colonoscopy vs Air Insufflation Colonoscopy in Experienced Endoscopists Unknown status NCT01797406
7 Water Injection Colonoscopy vs Air Insufflation Colonoscopy in Training the Beginners Unknown status NCT01762735
8 "Air Assisted"Water Injection Colonoscopy in Experienced Endoscopists Unknown status NCT01797393
9 Ultrafine Endoscope for Unsedated Colonoscopy is an Effective Method to Reduce Abdominal Pain:a Prospective Randomized Study. Unknown status NCT02160210
10 The Low Rectal Cancer Study. Unknown status NCT02005965
11 Functional MRI of Hypoxia-mediated Rectal Cancer Aggressiveness Completed NCT01816607
12 Evaluation of Intestinal Vascolarization by Intraoperative Angiography With Indocianine Green During Laparoscopi Rectal Resection or Left Colectomy: Predictive Value on Anastomotic Leak. Completed NCT02662946
13 The Challenge of Assessing Infectious Risk and Visceral Closure in NOTES: A Prospective Study Examining Routine Colorectal Surgery as a Model in Humans Completed NCT01102725
14 3D High Resolution Anorectal Manometry in Children After Surgery for Anorectal Disorders Completed NCT02296008
15 A Randomized Trial Comparing Outcomes for the LigaSure and Disposable Stapling Instruments for Laparoscopic Surgery Completed NCT00487409
16 The Effects of Electronic Bidet on Anal Resting Pressure, Compared to Conventional Sitz Bath in Normal Healthy Volunteers Completed NCT02244840 Early Phase 1
17 Study Of PRoliferation and Apoptosis in Rectal caNcer as Predictive and Prognostic biOmarkers: a Histopathology and Imaging Analysis Completed NCT02486094
18 Evaluation of Anorectal Area in Children Using 3D High Resolution Anorectal Manometry. Completed NCT02236507
19 BowelScope: Accuracy of Detection Using ENdocuff Optimisation of Mucosal Abnormalities Completed NCT03072472
20 Effect of Need to Void on Rectal Sensory Function in Multiple Sclerosis, a Manometric Study Completed NCT04057222
21 Facilitation of Early Mobilization After Colorectal Surgery: A Randomized Controlled Trial Completed NCT02131844
22 Comparison of Caudal Block and Saddle Block on Anorectal Surgery Completed NCT03498547
23 Ano-rectal 3D High Resolution Manometry: Normal Values and Comparison With Ultrasound Examination in Healthy Volunteers, Patients With Fecal Incontinence and Patients With Constipation Completed NCT01710579
24 A Prospective Single-Center Evaluation of SureForm™ Staplers in Robotic-assisted Colorectal Procedures Recruiting NCT04247958
25 Pelvic Floor Dysfunction and Its Influence on Body Image and Sexual Function - A Prospective Study Through Pregnancy and Post-partum Recruiting NCT03591393
26 The Guarding Reflex Anal, Study of the Modulation Function of Rectal Distension Recruiting NCT04409054
27 Implementing Non-invasive Circulating Tumor DNA Analysis to Optimize the Operative and Postoperative Treatment for Patients With Colorectal Cancer - Intervention Trial 2 Recruiting NCT04084249
28 Prevention of Colorectal Cancer Through Multiomics Blood Testing Recruiting NCT04369053
29 Comparison of Rubber Band Ligation and Haemorrhoidectomy in Patients With Symptomatic Haemorrhoids Grade III: a Multicentre, Randomized Controlled Trial and Cost-utility Analysis. Recruiting NCT04621695
30 Molecular, Pathologic and MRI Investigation of the Prognostic and Redictive Importance of Extramural Venous Invasion in Rectal Cancer Active, not recruiting NCT01995942
31 Multi-center Prospective Randomized Controlled Study of the Single-incision Laparoscopic Surgery Versus Conventional Laparoscopic Surgery for Colorectal Cancer Not yet recruiting NCT03633539
32 A Single Institutional Randomized Controlled Trial for A Multimodal Enhanced Recovery Program in Anorectal Surgery Terminated NCT03992079
33 EnSeal Efficacy and Bursting Pressure in Human Vessels Withdrawn NCT01312246

Search NIH Clinical Center for Rectal Disease

Cochrane evidence based reviews: rectal diseases

Genetic Tests for Rectal Disease

Anatomical Context for Rectal Disease

MalaCards organs/tissues related to Rectal Disease:

Colon, Spinal Cord, Prostate, Liver, Bone Marrow, Bone, Kidney

Publications for Rectal Disease

Articles related to Rectal Disease:

(show top 50) (show all 255)
# Title Authors PMID Year
Different moxibustion therapies for urinary retention after anorectal surgery: A protocol for systematic review and network meta-analysis. 42
33466185 2021
Laparoscopic anterior resection of rectum for rectal deeply infiltrating endometriosis: A short-term prospective randomized trial. 42
33217865 2020
Uncovered self-expandable metal stents for the treatment of refractory benign colorectal anastomotic stricture. 42
33199742 2020
[Healing of severe morbus Crohn-related pyoderma gangrenosum after colectomy]. 61
33734075 2021
Transanal Total Mesorectal Excision: Short-term Outcomes of 1283 Cases from a Nationwide Registry in China. 61
33395134 2021
Colonic Crohn's disease - decision is more important than incision: A surgical dilemma. 61
33552390 2021
Metachronous advanced neoplasia after submucosal invasive colorectal cancer resection. 61
33479474 2021
Use of the End to End Anastomotic Stapler From Above for Difficult Pelvic Surgery for Distal Rectal Disease. 61
33342264 2020
The Effects of Neoadjuvant Treatment on the Tumor Microenvironment in Rectal Cancer: Implications for Immune Activation and Therapy Response. 61
32387305 2020
Mark M. Ravitch MD: Surgeon, author, teacher, soldier. 61
32682543 2020
Transanal Endoscopic Microsurgery: Endoscopy Assisted Treatment of Colorectal Anastomotic Stenosis. 61
32178496 2020
The Use of Enhanced Technologies in Robotic Surgery and Its Impact on Outcomes in Rectal Cancer: A Systematic Review. 61
32484427 2020
Simple water-based tacrolimus enemas for refractory proctitis. 61
32782938 2020
Evolution of Transanal Total Mesorectal Excision. 61
32351334 2020
Diagnostic value of platelet-lymphocyte ratio and hemoglobin-platelet ratio in patients with rectal cancer. 61
31960471 2020
Colorectal Cancer in the Young: Epidemiology, Prevention, Management. 61
32315236 2020
The treatment for refractory rectovaginal fistula after low anterior resection with estriol, polyglycolic acid sheets and primary closure: A case report. 61
33076201 2020
Minimally invasive approach to low-velocity penetrating extraperitoneal rectal trauma. 61
32426526 2020
Damage control surgery in neonates: Lessons learned from the battlefield. 61
31103271 2019
MRI reveals different Crohn's disease phenotypes in children and adults. 61
30729332 2019
Advanced Application of TaTME Platform For a T4 Anterior Rectal Tumor. 61
31135710 2019
[Establishment and expansion of transanal endoscopic surgery system]. 61
30919369 2019
Safety and Feasibility of Transanal Endoscopic Surgery for Diffuse Cavernous Hemangioma of the Rectum. 61
31320895 2019
Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio Are Not Prognostic Biomarkers in Rectal Cancer Patients with Curative Resection. 61
29687424 2018
Pelvic MRI: Is Endovaginal or Rectal Filling Needed? 61
29713217 2018
TC Rectal Pathology: Findings at CT-Colonography. 61
29169607 2018
Extra-rectal lymphogranuloma venereum in France: a clinical and molecular study. 61
28698211 2018
Anticipation of umbistoma in laparoscopic anterior rectal resection: Ileostomy and ostomy closure. 61
31559347 2018
Molecular classification of Crohn's disease reveals two clinically relevant subtypes. 61
27742763 2018
Quantitative Perfusion Analysis of the Rectum Using Golden-Angle Radial Sparse Parallel Magnetic Resonance Imaging: Initial Experience and Comparison to Time-Resolved Angiography With Interleaved Stochastic Trajectories. 61
28622248 2017
Transanal Assisted Resection with Closure of Anal Canal for Lower Rectal Diseases. 61
28982899 2017
Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients. 61
28132889 2017
Solitary Rectal Ulcer Syndrome: A Paediatric Case Report. 61
28848799 2017
[Anal acute pain]. 61
30512847 2017
Predicting Outcomes to Optimize Disease Management in Inflammatory Bowel Diseases. 61
27282402 2016
Advances in management of adjuvant chemotherapy in rectal cancer: Consequences for clinical practice. 61
27156922 2016
Atlas-guided generation of pseudo-CT images for MRI-only and hybrid PET-MRI-guided radiotherapy treatment planning. 61
27524504 2016
Topographic Anatomy of the Anal Sphincter Complex and Levator Ani Muscle as It Relates to Intersphincteric Resection for Very Low Rectal Disease. 61
27050605 2016
Clinical recurrence and re-resection rates after extensive vs. segmental colectomy in Crohn's colitis: a retrospective cohort study. 61
26886936 2016
Evaluation of postoperative anal functions using endoanal ultrasonography and anorectal manometry in children with congenital anorectal malformations. 61
26563525 2016
Predictors of Outcome of Rectovaginal Fistula Surgery in Women With Crohn's Disease. 61
26767081 2016
Laparoscopic colorectal surgery: Current status and implementation of the latest technological innovations. 61
26811618 2016
Heat shock protein 70 is a useful marker for predicting colorectal cancer. 61
26854442 2015
Descending perineum syndrome: new perspectives. 61
26047661 2015
Optimizing technology for the management of colon and rectal diseases. 61
25897589 2015
Laparoscopic versus open fecal diversion: does laparoscopy offer better outcomes in short term? 61
25796388 2015
Transanal total mesorectal excision in rectal cancer: short-term outcomes in comparison with laparoscopic surgery. 61
25185463 2015
Diffusion-weighted MR imaging of the rectum: clinical applications. 61
25132166 2014
[Plasmablastic lymphoma: a case of rectal disease with bone marrow involvement in a HIV positive patient]. 61
25594760 2014
Complications and outcomes following rectal pull-through surgery in dogs with rectal masses: 74 cases (2000-2013). 61
25181273 2014

Variations for Rectal Disease

Expression for Rectal Disease

Search GEO for disease gene expression data for Rectal Disease.

Pathways for Rectal Disease

Pathways related to Rectal Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Super pathways Score Top Affiliating Genes
Show member pathways
14.1 TP53 TNF TLR8 TLR7 IL6 IL2
Show member pathways
13.89 TP53 TNF IL6 IL2 IL1B IL10
Show member pathways
13.74 TP53 TNF IL6 IL2 IL1B IL10
Show member pathways
13.43 TP53 TNF IL6 IL2 IL1B IL10
Show member pathways
13.43 TP53 TNF TLR8 TLR7 IL6 IL2
Show member pathways
13.37 TNF IL6 IL2 IL1B IL10 CXCL8
Show member pathways
13.3 TP53 TNF TLR8 TLR7 IL6 IL2
Show member pathways
9 12.92 TP53 KLK3 IL6 IL2 CXCL8 CDKN2A
Show member pathways
12.92 TP53 TNF TLR7 IL6 IL2 IL1B
Show member pathways
Show member pathways
Show member pathways
12.79 TNF TLR8 TLR7 IL6 IL2 IL1B
Show member pathways
12.71 TNF IL6 IL2 IL1B IL10 CD8A
Show member pathways
12.7 TNF IL6 IL2 IL1B IL10 CD4
Show member pathways
Show member pathways
12.69 TP53 TNF IL6 IL2 IL1B IL10
18 12.66 TNF TLR8 TLR7 IL2 IL1B IL10
19 12.46 TP53 TNF IL6 IL2 CDKN2A CD4
Show member pathways
12.44 TNF IL6 IL2 IL10 CXCL8 CCR6
Show member pathways
12.4 TP53 TNF IL6 IL1B CXCL8
Show member pathways
12.38 TNF IL6 IL1B CXCL8
Show member pathways
Show member pathways
12.37 TP53 TNF IL6 IL2 IL1B IL10
Show member pathways
12.33 TP53 TNF MTRR IL6 IL2 IL1B
Show member pathways
12.31 TNF TLR8 IL6 IL2 IL1B IL10
27 12.3 TNF IL6 IL1B CXCL8
28 12.29 TNF IL6 IL1B IL10
29 12.29 TP53 TNF TLR8 TLR7 IL6
30 12.28 TNF IL6 IL1B IL10 CXCL8
Show member pathways
32 12.22 TP53 IL6 CXCL8 CDKN2A
Show member pathways
12.15 TP53 TLR8 TLR7 IL2 IL1B
34 12.07 TP53 IL6 IL1B CXCL8 CDKN2A
Show member pathways
12.06 IL2 IL1B CD8A CD4
36 12.05 TNF IL6 IL1B IL10 CXCL8
37 12.05 TP53 TNF IL6 IL2 IL1B CXCL8
38 12.01 TP53 TNF IL6 IL1B IL10 CXCL8
39 12 TNF IL6 IL1B CXCL8
Show member pathways
11.98 TLR8 TLR7 IL6 IL1B CD4
41 11.98 TNF IL6 IL2 IL10 GP5 CD8A
42 11.97 TNF IL6 IL1B CXCL8
43 11.91 TP53 IL6 IL2 CXCL8
44 11.91 TNF IL6 IL1B GP5 CD8A CD4
45 11.89 TNF IL6 IL2 IL1B IL10 CXCL8
46 11.88 TNF IL6 IL1B IL10 CXCL8
Show member pathways
11.8 TNF IL2 CXCL8
48 11.79 TNF IL6 IL10 ICOSLG CCR6
49 11.78 TP53 CXCL8 CDKN2A
50 11.78 TNF IL6 IL1B CXCL8

GO Terms for Rectal Disease

Cellular components related to Rectal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TNF MIR99B KLK3 IL6 IL2 IL1B
2 external side of plasma membrane GO:0009897 9.1 TNF TLR8 ICOSLG CD8A CD4 CCR6

Biological processes related to Rectal Disease according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.31 TLR8 TLR7 IL6 IL1B IL10 ICOSLG
2 immune system process GO:0002376 10.17 TLR8 TLR7 IL2 ICOSLG CD8A CD4
3 positive regulation of transcription, DNA-templated GO:0045893 10.1 TP53 TNF IL6 IL1B IL10 CDKN2A
4 negative regulation of cell proliferation GO:0008285 10.05 TP53 IL6 IL1B IL10 CXCL8 CDKN2A
5 positive regulation of gene expression GO:0010628 10 TP53 TNF IL6 IL1B CXCL8 CRP
6 positive regulation of protein phosphorylation GO:0001934 9.97 TNF IL2 IL1B CD4
7 inflammatory response GO:0006954 9.91 TNF TLR8 TLR7 IL6 IL1B CXCL8
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.89 TNF IL6 IL1B IL10
9 cellular response to lipopolysaccharide GO:0071222 9.89 TNF IL6 IL1B IL10 CXCL8
10 regulation of insulin secretion GO:0050796 9.87 TNF IL6 IL1B
11 positive regulation of inflammatory response GO:0050729 9.87 TNF TLR7 IL2 IL1B
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.86 TNF IL6 IL2
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.86 TNF TLR7 IL1B
14 response to glucocorticoid GO:0051384 9.86 TNF IL6 IL10
15 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.85 TNF TLR8 TLR7
16 regulation of protein phosphorylation GO:0001932 9.85 TNF TLR8 TLR7
17 humoral immune response GO:0006959 9.84 TNF IL6 CCR6
18 positive regulation of interleukin-1 beta production GO:0032731 9.84 TNF TLR8 IL6
19 T cell activation GO:0042110 9.82 ICOSLG CD8A CD4
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 TNF MIR99B IL1B
21 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.81 TP53 TNF IL10
22 positive regulation of T cell proliferation GO:0042102 9.81 IL6 IL2 IL1B CD4
23 positive regulation of chemokine production GO:0032722 9.8 TNF TLR7 IL6
24 negative regulation of mitotic cell cycle GO:0045930 9.8 TP53 TNF IL10
25 positive regulation of JAK-STAT cascade GO:0046427 9.78 TNF IL6 IL10
26 microglial cell activation GO:0001774 9.77 TNF TLR8 TLR7
27 negative regulation of neurogenesis GO:0050768 9.76 TNF IL6 IL1B
28 positive regulation of immunoglobulin production GO:0002639 9.72 IL6 IL2 IL10
29 positive regulation of interleukin-6 production GO:0032755 9.72 TNF TLR8 TLR7 IL6 IL1B
30 positive regulation of glial cell proliferation GO:0060252 9.71 TNF IL6 IL1B
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 TNF IL1B IL10
32 endothelial cell apoptotic process GO:0072577 9.68 TNF IL10
33 negative regulation of cytokine production involved in immune response GO:0002719 9.66 TNF IL10
34 positive regulation of fever generation GO:0031622 9.65 TNF IL1B
35 positive regulation of neuroinflammatory response GO:0150078 9.65 TNF IL6 IL1B
36 positive regulation of interferon-gamma production GO:0032729 9.65 TNF TLR8 TLR7 IL2 IL1B
37 sequestering of triglyceride GO:0030730 9.64 TNF IL1B
38 positive regulation of plasma cell differentiation GO:1900100 9.62 IL2 IL10
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 TNF IL1B
40 negative regulation of lipid storage GO:0010888 9.61 TNF IL6 CRP
41 vascular endothelial growth factor production GO:0010573 9.58 TNF IL6 IL1B
42 cytokine-mediated signaling pathway GO:0019221 9.56 TP53 TNF IL6 IL2 IL1B IL10
43 positive regulation of interleukin-8 production GO:0032757 9.55 TNF TLR8 TLR7 IL6 IL1B
44 immune response GO:0006955 9.36 TNF TLR8 TLR7 IL6 IL2 IL1B

Molecular functions related to Rectal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TNF IL6 IL2 IL1B IL10 CXCL8
2 MDM2/MDM4 family protein binding GO:0097371 8.96 TP53 CDKN2A

Sources for Rectal Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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