Aliases & Classifications for Rectal Disease

MalaCards integrated aliases for Rectal Disease:

Name: Rectal Disease 12 15
Rectal Diseases 44 73
Rectal Disorders 43

Classifications:



External Ids:

Disease Ontology 12 DOID:1285
MeSH 44 D012002
SNOMED-CT 68 5964004
UMLS 73 C0034882

Summaries for Rectal Disease

MedlinePlus : 43 The rectum is the lower part of your large intestine where your body stores stool. Problems with rectum are common. They include hemorrhoids, abscesses, incontinence and cancer. Many people are embarrassed to talk about rectal troubles. But seeing your doctor about problems in this area is important. This is especially true if you have pain or bleeding. Treatments vary depending on the particular problem. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Rectal Disease, also known as rectal diseases, is related to proctitis and prostatitis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Rectal Disease is KIDINS220 (Kinase D Interacting Substrate 220), and among its related pathways/superpathways is MSP-RON Signaling. The drugs Aspirin and Diltiazem have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and testes.

Related Diseases for Rectal Disease

Diseases related to Rectal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 proctitis 31.4 KLK3 TNF
2 prostatitis 28.7 KLK3 TNF
3 hemorrhoid 11.2
4 anal fistula 10.7 AHSP KIDINS220
5 neurogenic bowel 10.6 DCXR KIDINS220
6 urethral diverticulum 10.6 KIDINS220 KLK3
7 urethral syndrome 10.5 KIDINS220 KLK3
8 anus disease 10.3 CLP1 KATNB1
9 coronary artery aneurysm 10.3 AHSP KLK3
10 paraphimosis 10.3 KANTR KLK3
11 diverticulitis 10.2 DCXR TNF
12 factitious disorder 10.2 DCXR KANTR
13 anismus 10.1 KANTR PDPR
14 radiation cystitis 10.1 KANTR KLK3
15 lacrimal apparatus disease 10.0 DCXR TNF
16 trench fever 9.9 KANTR TNF
17 chronic salpingitis 9.8 KANTR TNF
18 prostate cancer 9.5
19 aging 9.5
20 lymphoma 9.5
21 prostate disease 9.5
22 plasmablastic lymphoma 9.5
23 extrinsic cardiomyopathy 9.5 KANTR TNF

Graphical network of the top 20 diseases related to Rectal Disease:



Diseases related to Rectal Disease

Symptoms & Phenotypes for Rectal Disease

UMLS symptoms related to Rectal Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, pruritus ani, rectal pain, rectal tenesmus, gastrointestinal gas

Drugs & Therapeutics for Rectal Disease

Drugs for Rectal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 804)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
2
Diltiazem Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 42399-41-7 39186
3
Epirubicin Approved Phase 4,Phase 2 56420-45-2 41867
4
Ethiodized oil Approved, Investigational Phase 4,Phase 2 8008-53-5
5
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 61825-94-3 5310940 9887054 43805 6857599
6
Raltitrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 112887-68-0 104758
7
Erythromycin Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 114-07-8 12560
8
Iron Approved Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6 23925
9
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-21-8 3385
10
Tegafur Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 17902-23-7 5386
11
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 216974-75-3
12
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 97682-44-5, 100286-90-6 60838
13
Levoleucovorin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68538-85-2
14
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
15
Bisacodyl Approved Phase 4,Phase 3,Phase 2,Not Applicable 603-50-9
16
Cetuximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 205923-56-4 56842117 2333
17
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
18
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
19
Iodine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 7553-56-2 807
20
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-84-3 187
21
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
22
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
23
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
24
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154361-50-9 60953
25
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9005-49-6 772 46507594
26
Adalimumab Approved Phase 4,Phase 3,Not Applicable 331731-18-1 16219006
27
Celecoxib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 169590-42-5 2662
28
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2216-51-5 16666
29
Glycerol Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 56-81-5 753
30
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
31
Zinc Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 7440-66-6 23994
32
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 443-48-1 4173
33
Nitroglycerin Approved, Investigational Phase 4,Phase 3,Phase 1 55-63-0 4510
34
Nitric Oxide Approved Phase 4,Phase 1 10102-43-9 145068 160954
35
Sucralfate Approved Phase 4 54182-58-0 0
36
Morphine Approved, Investigational Phase 4,Phase 3 57-27-2 5288826
37
Ketamine Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 6740-88-1 3821
38
Diclofenac Approved, Vet_approved Phase 4,Phase 2 15307-86-5 3033
39
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable,Early Phase 1 437-38-7 3345
40
Prilocaine Approved Phase 4,Phase 3 721-50-6 4906
41
Magnesium citrate Approved Phase 4,Phase 3 3344-18-1
42
Udenafil Approved, Investigational Phase 4,Phase 2 268203-93-6 6918523
43
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
44
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
45
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
46
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
47
Indomethacin Approved, Investigational Phase 4,Phase 1,Phase 2 53-86-1 3715
48
Darbepoetin alfa Approved, Investigational Phase 4 11096-26-7, 209810-58-2
49
Ropivacaine Approved Phase 4,Phase 3,Not Applicable 84057-95-4 71273 175805
50
Acetaminophen Approved Phase 4,Phase 3,Not Applicable 103-90-2 1983

Interventional clinical trials:

(show top 50) (show all 4345)
# Name Status NCT ID Phase Drugs
1 The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin Unknown status NCT01549418 Phase 4 Aspirin (ASA);Placebo
2 Pediatrics Anal Fissures Treatment With Polyethylene Glycol Unknown status NCT02419534 Phase 4 Polyethylene glycol;Polyethylene glycol with Diltiazem
3 Oxaliplatin and Raltitrexed Treatment of Colorectal Cancer With Liver Metastases Unknown status NCT02557490 Phase 4 oxaliplatin and raltitrexed
4 A Prospective Evaluation of the Strattice-LIFT to Treat Anal Fistula Unknown status NCT02423330 Phase 4
5 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version Unknown status NCT02354560 Phase 4 Erythromycin
6 Trial Comparing Ferric(III)Carboxymaltose Infusion With Oral Iron Suppletion as Treatment of Anaemia Unknown status NCT02243735 Phase 4 Ferrous fumarate;ferric(III)carboxymaltose
7 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Unknown status NCT02216305 Phase 4
8 Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Unknown status NCT02175914 Phase 4 Erythromycin
9 Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer Unknown status NCT01972503 Phase 4 5-FU and oxaliplatin
10 Avastin in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01972490 Phase 4 avastin+chemotherapy of mFOLFOX6 or FOLFIRI;chemotherapy of mFOLFOX6 or FOLFIRI
11 NK Activity Modulation Induced by Intravenous Lidocaine During Colorectal Laparoscopic Surgery Unknown status NCT01841294 Phase 4 Intravenous Lidocaine;Normal saline infusion
12 Participation and Detection Rate Diagnostic of a Colorectal Cancer Screening Program: CT Colonography vs. Flexible Sigmoidoscopy Unknown status NCT01739608 Phase 4
13 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Unknown status NCT01695863 Phase 4 comparing 2 drugs on their effect on the bowel preparation for colonoscopy
14 Cetuximab in Combination With Chemotherapy for the Treatment of Metastatic Colorectal Cancer Unknown status NCT01564810 Phase 4 Cetuximab;chemotherapy of mFOLFOX6 or FOLFIRI
15 FOLFIRI in Combination With Cetuximab in the First-line Treatment of Metastatic Colorectal Cancer Including a Regular Dermal Prophylaxis to Prevent Acneiforme Follicular Exanthema Unknown status NCT01315990 Phase 4 FOLFIRI + Cetuximab
16 New Adjuvant Chemotherapy of Non Resectable Liver Metastasis of Colorectal Cancer Without Bleeding, Obstruction Unknown status NCT01307878 Phase 4 chemotherapy ± targeted therapy
17 Continuous Infusion of Local Anesthetic for Optimal Post Operative Pain Control Following Hemorrhoidectomy Unknown status NCT01099605 Phase 4
18 OPTIMOX1 in Chinese mCRC Patients Unknown status NCT01023633 Phase 4 Oxaliplatin, LV, 5-FU
19 Preoperative Transhepatic Arterial Chemotherapy (TAC) in the Treatment of Liver Metastasis of Resectable Colorectal Cancer Unknown status NCT00874406 Phase 4 tac + folfox4;folfox4
20 Transhepatic Arterial Chemotherapy (TAC) Versus Transcatheter Arterial Chemoembolization (TACE) Plus Folfox4 as the Treatment of Unresectable Liver Metastasis of Colorectal Cancer Unknown status NCT00868569 Phase 4
21 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
22 Preoperative Assessment of Colon Tumor Unknown status NCT00114829 Phase 4
23 Polyacrylamide Hydrogel Injection Treatment for Anal Incontinence Completed NCT02550899 Phase 4
24 Comparison of Treatment Success of Botox Injection in the Internal Sphincter Versus Isosorbidedinitrate Ointment in Patients With an Anal Fissure Completed NCT00827736 Phase 4 ISDN ointment;Placebo
25 Combined Therapy in Radiation Proctopathy Completed NCT01613534 Phase 4 Sucralfate;Placebo
26 Ability to Maintain or Achieve Clinical and Endoscopic Remission With MMX Mesalamine Once Daily in Adults With Ulcerative Colitis Completed NCT01124149 Phase 4 MMX mesalamine/ mesalazine
27 Safety and Efficacy of the Addition of Morphine Chloride to a Low Dose of Bupivacaine as Intradural Anaesthetic for the Removal Surgery of the Hemorrhoids Completed NCT02046772 Phase 4 Bupivacaine low dose;Bupivacaine standard dose;Morphine Chloride
28 A Comparative Efficacy and Safety Study of Compound Carraghenates Cream With Mayinglong Musk Hemorrhoid Ointment in the Treatment of Hemorrhoids Completed NCT01881282 Phase 4 Carraghenates Cream;Mayinglong Musk Hemorrhoid Ointment
29 Improvement of Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse Completed NCT02449915 Phase 4 Bupivacaine;Placebo
30 Comparison Between Excisional Hemorrhoidectomy and Haemorrhoidal Dearterialisation With Anopexy Completed NCT01263431 Phase 4
31 Symptom Control 1-year After Circular Stapler Anopexy or Diathermy Excision for Prolapsed Haemorhoids Completed NCT00841620 Phase 4
32 Effect of Perioperative i.v. Low-dose S(+) Ketamine Completed NCT00354029 Phase 4 S (+) Ketamine;Placebo
33 What Benefit With a New Stapler Device in the Surgical Treatment of Obstructed Defecation? Completed NCT00810745 Phase 4
34 Sacral Nerve Stimulation for Anal Incontinence and Bowel Control Completed NCT00200005 Phase 4
35 Efficacy and Safety of CLIFE1 Gel in Benign Anorectal Surgery Completed NCT02961855 Phase 4 anesthesics plus antiinflammatory, CLIFE1;local anesthesics, CLIFE2
36 Discharge Conditions of Spinal Anesthesia With Heavy Prilocaine-Fentanyl and Heavy Bupivacaine-Fentanyl Completed NCT01880775 Phase 4 Prilocaine;Bupivacaine
37 Pain Relief for Thrombosed External Haemorrhoids Completed NCT00717782 Phase 4
38 RCT: STARR vs Biofeedback Completed NCT00556283 Phase 4
39 Chemotherapy Combined With CIK Treating Colon Cancer Completed NCT03084809 Phase 4 Cytokine-induced killer cells+ FOLFOX4;FOLFOX4
40 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum Completed NCT02582970 Phase 4 5-Fluorouracil;Bevacizumab;Irinotecan;Oxaliplatin
41 A Study of Capecitabine (Xeloda) in the Adjuvant Treatment of Participants With Resected Colon Cancer Completed NCT02581423 Phase 4 Capecitabine
42 A Study of Capecitabine (Xeloda) in Patients With Metastatic Colorectal Cancer Completed NCT02567331 Phase 4 Capecitabine
43 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
44 Intravenous Iron: Measuring Response in Anemic Surgical Patients Completed NCT02057471 Phase 4 Intravenous ferric carboxymaltose
45 Early Intervention for Erectile Dysfunction After Laparoscopic Resection for Rectal Cancer Completed NCT01912586 Phase 4
46 Nutrition for Colorectal Cancer Patients and Neutrophil Functions Completed NCT01831310 Phase 4
47 IVICA: Intravenous Iron in Colorectal Cancer Associated Anaemia Completed NCT01701310 Phase 4 Ferric carboxymaltose;Ferrous Sulphate
48 Medium Calorie Parenteral Nutrition on Patients With Gastrointestinal Cancer Undergoing Surgery Completed NCT01700062 Phase 4
49 A Study of Bevacizumab Plus 5-Flurouracil (5-FU) Based Doublet Chemotherapy as Neoadjuvant Therapy for Participants With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer Completed NCT01695772 Phase 4 5-FU based doublet chemotherapy;bevacizumab
50 A Multi-centre Study Comparing the Polyp Detection Rate of Two Different Types of Bowel Preparation: a 2-litre Solution (MOVIPREP®) Versus a Hyperosmotic and Stimulant Combined Low Volume Bowel Preparation (Sodium Picosulfate and Magnesium Citrate) Completed NCT01689792 Phase 4 MOVIPREP;CitraFleet

Search NIH Clinical Center for Rectal Disease

Cochrane evidence based reviews: rectal diseases

Genetic Tests for Rectal Disease

Anatomical Context for Rectal Disease

MalaCards organs/tissues related to Rectal Disease:

41
Liver, Colon, Testes, Lung, Lymph Node, Skin, Prostate

Publications for Rectal Disease

Articles related to Rectal Disease:

(show all 28)
# Title Authors Year
1
Topographic Anatomy of the Anal Sphincter Complex and Levator Ani Muscle as It Relates to Intersphincteric Resection for Very Low Rectal Disease. ( 27050605 )
2016
2
Elastosonography in malignant rectal disease: preliminary data. ( 17427082 )
2007
3
Plasmablastic lymphoma: a case of rectal disease with spinal cord compression. ( 17169819 )
2006
4
Radiofrequency surgery--novel techniques in the treatment of ano-rectal disease. ( 17139880 )
2006
5
Incidental discovery of ano-rectal disease during transrectal ultrasound performed for prostatic disease. ( 15906788 )
2005
6
A new technique of laparoscopic surgery for rectal disease. ( 15098039 )
2004
7
EUS for rectal disease. ( 12085043 )
2002
8
Use of colostomy to manage rectal disease in dogs. ( 9232784 )
1997
9
Medical malpractice involving colon and rectal disease. ( 8287753 )
1994
10
Medical malpractice involving colon and rectal disease: a 20-year review of United States civil court litigation. ( 8500369 )
1993
11
Endoscopic ultrasonography in the evaluation of colon and rectal disease. ( 2184084 )
1990
12
Colon and rectal disease 1947-1987. ( 3313352 )
1987
13
Coloanal anastomosis in the management of benign and malignant rectal disease. ( 3675022 )
1987
14
Lord's rectal dilitation and treatment of rectal disease. ( 3998626 )
1985
15
The effects on pelvic visceral function of anal sphincter ablating and anal sphincter preserving operations for cancer of the lower part of the rectum and for benign colo-rectal disease. ( 6691700 )
1984
16
Colonoscopic retroflexion in the evaluation of rectal disease. ( 7137139 )
1982
17
The prone cross-table lateral view of the rectum: a useful projection in the evaluation of rectal disease. ( 7165608 )
1982
18
Rectal disease in a patient with delirium tremens. ( 7365944 )
1980
19
The role of fiberoptic colonoscopy in the diagnosis of colonic and rectal disease. ( 4746166 )
1973
20
Investigation of colonic and rectal disease. Arteriography. ( 4642021 )
1972
21
Symposium on canine recto-anal disorders--II: The surgical pathology of ano-rectal disease in the dog. ( 5691229 )
1968
22
Colonic and rectal disease in the young adult. ( 13975128 )
1962
23
Relation of ano-rectal disease to carcinoma; with special reference to hemorrhoids. ( 13340006 )
1956
24
Recent advances in the surgical treatment of colon and rectal disease. ( 18152700 )
1949
25
Ano-rectal disease; incidence in 300 males of military age with particular reference to polyposis. ( 18108281 )
1949
26
Treatment of patients with rectal disease. ( 20248643 )
1947
27
LOCAL ANAESTHESIA IN ANO-RECTAL DISEASE. ( 20321127 )
1938
28
Remarks on Two Cases of Rectal Disease Treated by Modified Operative Methods. ( 20755289 )
1895

Variations for Rectal Disease

Expression for Rectal Disease

Search GEO for disease gene expression data for Rectal Disease.

Pathways for Rectal Disease

Pathways related to Rectal Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.3 KLK3 TNF

GO Terms for Rectal Disease

Biological processes related to Rectal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glucose metabolic process GO:0006006 8.62 DCXR TNF

Sources for Rectal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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