MCID: RCT018
MIFTS: 59

Rectal Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Rectal Neoplasm

MalaCards integrated aliases for Rectal Neoplasm:

Name: Rectal Neoplasm 12 76 15
Rectal Cancer 12 55 15
Rectal Carcinoma 55 73
Rectal Neoplasms 44 73
Rectum Cancer 12 15
Malignant Neoplasm of Rectum 12
Malignant Tumor of Rectum 12
Malignant Rectal Neoplasm 73
Adenocarcinoma of Rectum 73
Carcinoma of the Rectum 12
Malignant Rectal Tumor 12
Malignant Rectum Tumor 12
Carcinoma of Rectum 12
Neoplasm of Rectum 12
Cancer of Rectum 12
Rectum Neoplasm 12
Cancer, Rectal 40
Rectal Tumors 73
Rectal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1984 DOID:1993
MeSH 44 D012004
ICD10 33 C20
ICD9CM 35 154.1
SNOMED-CT 68 93984006

Summaries for Rectal Neoplasm

Disease Ontology : 12 A colorectal cancer that is located in the rectum.

MalaCards based summary : Rectal Neoplasm, also known as rectal cancer, is related to lynch syndrome and rectum adenocarcinoma. An important gene associated with Rectal Neoplasm is TYMS (Thymidylate Synthetase), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Avastin and Campostar have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lymph node, and related phenotypes are digestive/alimentary and neoplasm

Wikipedia : 76 Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from... more...

Related Diseases for Rectal Neoplasm

Diseases related to Rectal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 367)
# Related Disease Score Top Affiliating Genes
1 lynch syndrome 32.3 KRAS MLH1 MSH2 TP53
2 rectum adenocarcinoma 31.6 CAGE1 CEACAM5 KRT20 KRT7 SLC14A2
3 colorectal cancer 30.8 CEACAM5 DPYD HRAS KRAS KRT20 KRT7
4 adenosquamous carcinoma 30.4 KRAS KRT7 TP53
5 familial adenomatous polyposis 30.4 KRAS MLH1 MSH2 TP53
6 anus cancer 30.2 KRT7 SLC14A2 SMUG1
7 anal fistula 30.2 MLH1 MSH2
8 rectosigmoid junction neoplasm 30.2 KRAS SMUG1
9 small cell carcinoma 30.0 KRT20 KRT7 TP53
10 adenocarcinoma 29.9 HRAS KRAS MLH1 TP53
11 adenoma 29.9 KRAS MLH1 MSH2 TP53
12 linitis plastica 29.9 KRT20 KRT7
13 bladder adenocarcinoma 29.8 HRAS KRT20 KRT7
14 cystic teratoma 29.8 KRT20 KRT7 TP53
15 transitional cell carcinoma 29.8 HRAS KRT20 KRT7 MSH2 TP53
16 pseudomyxoma peritonei 29.8 KRAS KRT20 KRT7 TP53
17 intrahepatic cholangiocarcinoma 29.7 KRAS KRT20 KRT7 TP53
18 carcinosarcoma 29.7 HRAS KRAS KRT7 TP53
19 myeloma, multiple 29.6 HRAS KRAS SMUG1 TP53
20 cholangiocarcinoma 29.5 CEACAM5 KRAS KRT20 KRT7 MMP7 TP53
21 gastric cancer 29.5 CEACAM5 DPYD KRAS KRT20 MLH1 MMP7
22 esophageal cancer 29.4 CEACAM5 DPYD HRAS KRAS MMP7 TP53
23 rectal cancer, childhood 12.1
24 rectum sarcoma 11.1
25 rectal cloacogenic carcinoma 11.1
26 rectum sarcomatoid carcinoma 11.1
27 squamous cell carcinoma 10.6
28 pancreatic cystadenocarcinoma 10.4 CEACAM5 KRAS
29 hyperplastic polyposis syndrome 10.3 KRAS TP53
30 atypical follicular adenoma 10.3 CEACAM5 TP53
31 schimmelpenning-feuerstein-mims syndrome 10.3 HRAS KRAS
32 adenoid squamous cell carcinoma 10.3 KRT20 KRT7
33 intratubular embryonal carcinoma 10.3 KRT20 KRT7
34 bile duct mucoepidermoid carcinoma 10.3 CEACAM5 KRT7
35 cutaneous adenocystic carcinoma 10.3 CEACAM5 KRT7
36 tolosa-hunt syndrome 10.3 CEACAM5 SMUG1
37 spitz nevus 10.3 HRAS TP53
38 ascending colon cancer 10.3 MSH2 SMUG1
39 intracranial chondrosarcoma 10.3 CEACAM5 TP53
40 appendix carcinoid tumor 10.3 MLH1 MSH2
41 gastrointestinal carcinoma 10.3 DPYD KRT20 TYMS
42 colorectal cancer, hereditary nonpolyposis, type 7 10.3 MLH1 MSH2
43 urachal adenocarcinoma 10.3 CEACAM5 KRAS
44 rare adenocarcinoma of the breast 10.3 KRAS TP53
45 colorectal cancer 5 10.3 DPYD MLH1
46 cutaneous mucoepidermoid carcinoma 10.3 CEACAM5 KRT7
47 anal gland adenocarcinoma 10.3 CEACAM5 KRT7
48 cystic basal cell carcinoma 10.3 KRT20 KRT7
49 liver lymphoma 10.3 CEACAM5 SMUG1
50 adenosquamous colon carcinoma 10.3 MLH1 MSH2

Comorbidity relations with Rectal Neoplasm via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Anus Cancer Colorectal Cancer
Deficiency Anemia Hydronephrosis
Intestinal Obstruction Neutropenia
Paralytic Ileus Protein-Energy Malnutrition
Rectosigmoid Junction Neoplasm Rectum Carcinoma in Situ

Graphical network of the top 20 diseases related to Rectal Neoplasm:



Diseases related to Rectal Neoplasm

Symptoms & Phenotypes for Rectal Neoplasm

MGI Mouse Phenotypes related to Rectal Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 APAF1 HRAS KRAS MLH1 MMP7 MSH2
2 neoplasm MP:0002006 9.23 APAF1 HRAS KRAS MLH1 MMP7 MSH2

Drugs & Therapeutics for Rectal Neoplasm

FDA approved drugs:

(show all 11)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Avastin 18 49 BEVACIZUMAB Genentech July 2009
2
Campostar 18 49 IRINOTECAN HYDROCHLORIDE Pharmacia & Upjohn June 1996
3
CEA-Scan 18 Immunomedics April 1996
4
Cyramza 18 49 RAMUCIRUMAB Eli Lilly April 2014
5
Eloxatin 18 49 OXALIPLATIN Sanofi-aventis August 2002
6
Erbitux 18 49 CETUXIMAB Imclone, Bristol-Myers Squibb February 2004
7
Fusilev 18 LEVOLEUCOVORIN CALCIUM Spectrum Pharmaceuticals March of 2008
8
Stivarga 18 49 REGORAFENIB Bayer/ Bayer HealthCare Pharmaceuticals February 2013/ September 2012
9
Vectibix 18 49 PANITUMUMAB Amgen September 2006
10
Xeloda 18 49 CAPECITABINE Roche April 1998/ May 2001
11
Zaltrap 18 49 ZIV-AFLIBERCEPT Sanofi-aventis August 2012

Drugs for Rectal Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 397)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
4
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
5
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
6
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
7
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
8
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
9
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
10
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
11
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
12
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
13
Orphenadrine Approved Phase 4 83-98-7 4601
14
Morphine Approved, Investigational Phase 4 57-27-2 5288826
15
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
16
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
17
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
18
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
19
Acetaminophen Approved Phase 4 103-90-2 1983
20
Methadone Approved Phase 4 76-99-3 4095
21
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
22
Udenafil Investigational Phase 4,Phase 2 268203-93-6 6918523
23 Ferric Compounds Phase 4
24 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
25 Iron Supplement Phase 4
26 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Hematinics Phase 4,Phase 3,Phase 2,Phase 1
28 Ferric oxide, saccharated Phase 4
29 Vasodilator Agents Phase 4,Phase 1,Phase 2
30 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Cola Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
32 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Sildenafil Citrate Phase 4 171599-83-0
34 Phosphodiesterase Inhibitors Phase 4,Phase 2
35 Citrate Phase 4
36 Phosphodiesterase 5 Inhibitors Phase 4,Phase 2
37 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Anesthetics, General Phase 4
40 Adjuvants, Anesthesia Phase 4
41 Adrenergic alpha-Agonists Phase 4
42 Analgesics Phase 4,Phase 2,Phase 1,Not Applicable
43 Narcotics Phase 4
44 Adrenergic Agonists Phase 4
45 Analgesics, Opioid Phase 4,Phase 3
46 Anesthetics, Intravenous Phase 4
47 Adrenergic Agents Phase 4,Phase 3
48 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Adrenergic alpha-2 Receptor Agonists Phase 4
50 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 966)
# Name Status NCT ID Phase Drugs
1 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
2 Early Intervention for Erectile Dysfunction After Laparoscopic Resection for Rectal Cancer Completed NCT01912586 Phase 4
3 Concentration of Ertapenem in Colorectal Tissue Completed NCT00535652 Phase 4 Ertapenem
4 Prospective Study of the Use of a Mesh to Prevent Parastomal Hernia After Laparoscopic Abdominoperineal Resection Completed NCT01722565 Phase 4
5 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed NCT01056913 Phase 4
6 The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer Completed NCT01421940 Phase 4 Placebo drug;Udenafil
7 The Effect of Dexmedetomidine on Postoperative Analgesia Completed NCT01373021 Phase 4 Fentanyl;Dexmedetomidine
8 Prospective Randomized Study of SILS Versus CLS for Rectal Cancer Completed NCT01579721 Phase 4
9 CHOICE: Communicating Health Options Through Information and Cancer Education Completed NCT00134589 Phase 4
10 Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia Recruiting NCT01975064 Phase 4 Propofol;Sevoflurane
11 Study of NOTES-TME Versus L-LAR in Rectal Cancer Recruiting NCT02550769 Phase 4
12 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery Recruiting NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
13 Transanal Endoscopic Microsurgery Versus Endoscopic Submucosal Dissection For Large Rectal Adenomas Suspended NCT01023984 Phase 4
14 Preoperative Hyperfractionated Radiotherapy or Radiochemotherapy in Locally Advanced Rectal Cancer. Unknown status NCT01814969 Phase 3
15 The Role of Indocyanine Green (ICG) Fluorescence Imaging on Anastomotic Leak in Robotic Colorectal Surgery Unknown status NCT02598414 Phase 2, Phase 3
16 Dose-escalation Trial of Preoperative Radiotherapy and Concurrent Chemotherapy in Locally Advanced Rectal Cancer Unknown status NCT02964468 Phase 3
17 Randomized Controlled Trial to Evaluate High Tie Versus Low Tie of the Inferior Mesenteric Artery in Anterior Resection Unknown status NCT01861678 Phase 3
18 Preoperative Downstaging of Extraperitoneal T3 Rectal Cancer: XELOXRT Versus XELACRT. A Multicenter, Phase III Study Unknown status NCT01653301 Phase 3 XELAC RT;XELOX RT
19 VSL#3 Versus Placebo in Increasing the Pathological Major Response Rate in Patients With Rectal Cancer Unknown status NCT01579591 Phase 3
20 A Trial to Assess Robot-assisted Surgery and Laparoscopy-assisted Surgery in Patients With Mid or Low Rectal Cancer Unknown status NCT01423214 Phase 3
21 Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Total Mesorectal Excision in T2-T3s N0, M0 Rectal Cancer Unknown status NCT01308190 Phase 3 Capecitabine (Xeloda)
22 Simultaneous Integrated Boost Preoperative Radiotherapy for Rectum Cancer Unknown status NCT01224392 Phase 3
23 A Trial of High Intensity Versus Low Intensity Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Unknown status NCT01064999 Phase 2, Phase 3 Oxaliplatin;Capecitabine
24 The Randomised Study of Preoperative Radiotherapy With Consolidating Chemotherapy for Unresectable Rectal Cancer Unknown status NCT00833131 Phase 3
25 Preoperative Radiotherapy and Local Excision in Rectal Cancer Unknown status NCT00738790 Phase 3
26 A Randomized Controlled Clinical Trial Comparing Oncological Results and Functional Recovery Between Laparoscopic and Open Method for the Treatment of Advanced Rectal Cancer After Concurrent Chemoradiation Therapy (CCRT) Unknown status NCT00601549 Phase 3
27 Preoperative Chemoradiation Versus Short Term Radiation Alone With Delayed Surgery for Stage II and III Resectable Rectal Cancer Unknown status NCT00597311 Phase 3
28 Randomized Prospective Trial for Laparoscopic vs Open Resection for Rectal Cancer Unknown status NCT00470951 Phase 3
29 COLOR II: Laparoscopic Versus Open Rectal Cancer Removal Unknown status NCT00297791 Phase 3
30 5FU/VL Vs LV5FU2 + CPT11 in Stage II-III Resected Rectal Cancer Unknown status NCT00189657 Phase 3
31 Transanual Tube Placement in Low Anterior Resection (LAR) for Rectal Cancer Unknown status NCT02905968 Phase 2, Phase 3
32 Laparoscopic Anterior Resection With or Without "Dog Ear" Double-stapled Anastomosis for Rectal Cancer Unknown status NCT02770911 Phase 3
33 Resource-Sparing Curative Treatment for Rectal Cancer Unknown status NCT01459328 Phase 3
34 Randomized Trial on Robotic Assisted Resection for Rectal Cancer Unknown status NCT01130233 Phase 3
35 Concurrent Chemoradiation Versus Wide Pelvic Lymphadenectomy for Advanced Rectal Cancer Unknown status NCT00154752 Phase 3
36 Comparison of Two Types of Surgery in Treating Patients With Rectal Cancer Unknown status NCT00007930 Phase 3
37 Mesh Reinforcement During Temporary Stoma Closure After Sphincter-Saving Rectal Cancer Surgery Unknown status NCT02576184 Phase 3
38 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
39 Local Excision in Downstaged Rectal Cancer Completed NCT00427375 Phase 3
40 Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy With 5-Fluorouracil and Oxaliplatin Versus 5-Fluorouracil Alone in Rectal Cancer Completed NCT00349076 Phase 3 5-FU and oxaliplatin;5-FU
41 Mesorectal Excision (ME) Versus ME With Lateral Node Dissection for Stage II, III Lower Rectal Cancer (JCOG0212) Completed NCT00190541 Phase 3
42 Capecitabine Versus Bolus 5-Fu Associated to Radiotherapy as Neoadjuvant Treatment for Rectal Cancer. Completed NCT03428529 Phase 2, Phase 3 Capecitabine Oral Product;5Fluorouracil
43 Efficiency of Two Dimensional High Definition Versus Three Dimensional Endoscopic Systems in Transanal Endoscopic Surgery Completed NCT01498354 Phase 3
44 Study of the Efficacy and Safety of Epoetin Alfa Administered Weekly in Patients With Gastric or Rectal Cancers Undergoing a Treatment Plan of Preoperative Chemotherapy and Radiation Therapy, Followed by Surgery Completed NCT00036400 Phase 3 epoetin alfa
45 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Metastatic Colorectal Cancer. Completed NCT00056459 Phase 3 Vatalanib
46 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Previously Treated Metastatic Colorectal Cancer Completed NCT00056446 Phase 3 Vatalanib
47 Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB Completed NCT00236249 Phase 3 Lidocaine
48 Neoadjuvant Radiotherapy Followed by Transanal Endoscopic Microsurgery for T1-T2 Extraperitoneal Rectal Cancer Completed NCT02127645 Phase 3
49 ELRR by TEM Versus Laparoscopic TME in iT2N0M0 SMALL LOW RECTAL CANCER Completed NCT01609504 Phase 3
50 Capecitabine in the Perioperative Treatment of Rectal Cancer Completed NCT01500993 Phase 3 Capecitabine;5-FU

Search NIH Clinical Center for Rectal Neoplasm

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: rectal neoplasms

Genetic Tests for Rectal Neoplasm

Anatomical Context for Rectal Neoplasm

MalaCards organs/tissues related to Rectal Neoplasm:

41
Colon, Liver, Lymph Node, Testes, Endothelial, Lung, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Rectal Neoplasm:

19
The Rectum

Publications for Rectal Neoplasm

Articles related to Rectal Neoplasm:

(show top 50) (show all 1002)
# Title Authors Year
1
Laparoscopic versus conventional open surgery in T4 rectal cancer: A case-control study. ( 30416145 )
2019
2
Prognostic value and interobserver variation of endoscopic ultrasound in the staging of rectal cancer. ( 30507643 )
2019
3
How to Report on Distal Resection Margins in Trials on Rectal Cancer Surgery. ( 30531269 )
2019
4
Pre-operative radiotherapy to improve local control and survival in rectal cancer optimal time intervals between radiation and surgery. ( 30319313 )
2019
5
A case report: Rectal endometriosis mimicking rectal cancer. ( 30391739 )
2018
6
Male sex and history of ischemic heart disease are major risk factors for anastomotic leakage after laparoscopic anterior resection in patients with rectal cancer. ( 30016941 )
2018
7
Markers of Mitochondrial Metabolism in Tumor Hypoxia, Systemic Inflammation, and Adverse Outcome of Rectal Cancer. ( 30273860 )
2018
8
Rectal cancer developing from an anastomotic site 18 years after resection due to intussusception caused by Peutz-Jeghers polyposis in a 31-year-old man: a case report. ( 30187147 )
2018
9
Rectal ischemia causes mass formation, masquerading as rectal cancer. ( 30159159 )
2018
10
Severe Treatment-Related Lymphopenia in Patients with Newly Diagnosed Rectal Cancer. ( 30095290 )
2018
11
The role of endoscopic evaluation for radiation proctitis in patients receiving intermediate-dose postoperative radiotherapy for rectal cancer. ( 30239826 )
2018
12
Anastomotic leakage after anterior resection in patients with rectal cancer previously irradiated for prostate cancer. ( 30503046 )
2018
13
Survival and peri-operative outcomes among patients with rectal cancer: the role of prior radiotherapy due to prostate cancer. ( 30327874 )
2018
14
Radiotherapy for one rectal cancer patient with cirrhosis and moderate to severe thrombocytopenia: a case report. ( 30214226 )
2018
15
Tumor thrombosis of the inferior mesenteric vein in a patient with rectal cancer. ( 30062432 )
2018
16
Feasibility of restorative proctocolectomy in patients with ulcerative colitis-associated lower rectal cancer: A retrospective study. ( 29454571 )
2018
17
A randomized clinical trial comparing the initial vascular approach to the inferior mesenteric vein versus the inferior mesenteric artery in laparoscopic surgery of rectal cancer and sigmoid colon cancer. ( 30377755 )
2018
18
Clinicopathological differences and survival outcomes with first-line therapy in patients with left-sided colon cancer and rectal cancer: Pooled analysis of 2879 patients from AGITG (MAX), COIN, FOCUS2, OPUS, CRYSTAL and COIN-B trials in the ARCAD database. ( 30268921 )
2018
19
Risk of secondary rectal cancer and colon cancer after radiotherapy for prostate cancer: a meta-analysis. ( 29961918 )
2018
20
Laparoscopic low anterior resection for rectal cancer with rectal prolapse: a case report. ( 29402298 )
2018
21
Overweight but not obesity is associated with decreased survival in rectal cancer. ( 30455587 )
2018
22
GI Cancers-Modulating the Modern Management of Gastrointestinal Malignancies: A Look at Liver Metastases, Rectal Cancer, Esophagogastric Cancer, and Anal Cancer. ( 29976479 )
2018
23
Can MR imaging be useful in differentiating low rectal cancer from anal cancer? ( 30171293 )
2018
24
Complete pathological response following neoadjuvant FOLFOX chemotherapy in BRCA2-mutant locally advanced rectal cancer: a case report. ( 30547773 )
2018
25
Functional outcomes and health-related quality of life following curative treatment for rectal cancer: A population-level study in England. ( 30553942 )
2018
26
The liver-first approach for locally advanced rectal cancer and synchronous liver metastases. ( 30554788 )
2018
27
ASO Author Reflections: Clarifying the Controversy Generated by Non-inferiority Trials of Laparoscopic Surgery for Rectal Cancer. ( 30556114 )
2018
28
Predictive value of 18F-FDG PET/CT on survival in locally advanced rectal cancer after neoadjuvant chemoradiation. ( 30556862 )
2018
29
A novel dynamic arc treatment planning solution to reduce dose to small bowel in preoperative radiotherapy for rectal cancer. ( 30360940 )
2018
30
Carbon-ion radiotherapy for locally recurrent rectal cancer: Japan Carbon-ion Radiation Oncology Study Group (J-CROS) Study 1404 Rectum. ( 30360998 )
2018
31
Diffusion and perfusion MR parameters to assess preoperative short-course radiotherapy response in locally advanced rectal cancer: a comparative explorative study among Standardized Index of Shape by DCE-MRI, intravoxel incoherent motion- and diffusion kurtosis imaging-derived parameters. ( 30361867 )
2018
32
Laparoscopic sphincter-saving surgery for low rectal cancer through marker meeting approach. ( 30363998 )
2018
33
Prognostic value of vascular endothelial growth factor receptor 1 and class III β-tubulin in survival for non-metastatic rectal cancer. ( 30364886 )
2018
34
Is adjuvant chemotherapy necessary for locally advanced rectal cancer patients with pathological complete response after neoadjuvant chemoradiotherapy and radical surgery? A systematic review and meta-analysis. ( 30368569 )
2018
35
A qualitative study exploring what it takes to be physically active with a stoma after surgery for rectal cancer. ( 30368673 )
2018
36
Delta radiomics for rectal cancer response prediction with hybrid 0.35 T magnetic resonance-guided radiotherapy (MRgRT): a hypothesis-generating study for an innovative personalized medicine approach. ( 30374650 )
2018
37
Short- and long-term outcomes of transanal versus laparoscopic total mesorectal excision for mid-to-low rectal cancer: a meta-analysis. ( 30374790 )
2018
38
Long-term Outcomes After Surgery Involving the Pelvic Floor in Rectal Cancer: Physical Activity, Quality of Life, and Health Status. ( 30374817 )
2018
39
Total neoadjuvant treatment (CAPOX plus radiotherapy) for patients with locally advanced rectal cancer with high risk factors: A phase 2 trial. ( 30381141 )
2018
40
Second primary malignancy risk after radiotherapy in rectal cancer survivors. ( 30386108 )
2018
41
Overstaged Rectal Cancer by MRI due to Fibrosis Induced by Tattoo Marker. ( 30386199 )
2018
42
Real-time in vivo optical biopsy using confocal laser endomicroscopy to evaluate distal margin in situ and determine surgical procedure in low rectal cancer. ( 30386986 )
2018
43
miR-21, miR-99b and miR-375 combination as predictive response signature for preoperative chemoradiotherapy in rectal cancer. ( 30388154 )
2018
44
Low Anterior Resection Syndrome and Quality of Life After Sphincter-Sparing Rectal Cancer Surgery: A Long-term Longitudinal Follow-up. ( 30394987 )
2018
45
Robotic Posterior Suturepexy for Colonic Prolapse Two Years After Transanal Total Mesorectal Excision for Low Rectal Cancer. ( 30399050 )
2018
46
Neoadjuvant (Chemo)radiotherapy With Total Mesorectal Excision Only Is Not Sufficient to Prevent Lateral Local Recurrence in Enlarged Nodes: Results of the Multicenter Lateral Node Study of Patients With Low cT3/4 Rectal Cancer. ( 30403572 )
2018
47
Splenic flexure mobilization in rectal cancer surgery: do we always need it? ( 30406931 )
2018
48
Oncological outcomes before and after the ELAPE-era in rectal cancer patients treated with abdominoperineal excision in a single center, high volume unit. ( 30411461 )
2018
49
High risk of permanent stoma after anastomotic leakage in anterior resection for rectal cancer. ( 30411471 )
2018
50
Diagnostic accuracy of endoscopic ultrasound, computed tomography, magnetic resonance imaging, and endorectal ultrasonography for detecting lymph node involvement in patients with rectal cancer: A protocol for an overview of systematic reviews. ( 30412090 )
2018

Variations for Rectal Neoplasm

Copy number variations for Rectal Neoplasm from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 139647 2 185171337 185512459 Copy number ZNF804A Rectal cancer
2 166960 3 1109627 1420278 Copy number CNTN6 Rectal cancer
3 225401 7 45400000 54000000 Copy number EGFR Rectal cancer

Expression for Rectal Neoplasm

Search GEO for disease gene expression data for Rectal Neoplasm.

Pathways for Rectal Neoplasm

Pathways related to Rectal Neoplasm according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 HRAS KRAS MLH1 MSH2 TP53
2 12.57 APAF1 HRAS KRAS MLH1 MSH2 TP53
3 12.27 DPYD MLH1 MSH2 TP53 TYMS
4
Show member pathways
11.96 APAF1 HRAS KRAS TP53
5 11.85 APAF1 MLH1 MSH2 TP53
6 11.57 KRAS MLH1 MMP7 MSH2 TP53
7
Show member pathways
11.52 APAF1 MMP7 TP53
8 11.5 HRAS KRAS TP53
9 11.49 HRAS KRAS TP53 TYMP
10 11.48 HRAS KRAS TP53
11 11.42 APAF1 MLH1 MSH2 TP53
12
Show member pathways
11.23 MLH1 MSH2 TP53
13 11.16 HRAS KRAS MLH1 MSH2 TP53
14
Show member pathways
11.15 DPYD SMUG1 TP53 TYMP TYMS
15 11.14 HRAS KRAS TP53
16 10.65 HRAS KRAS

GO Terms for Rectal Neoplasm

Cellular components related to Rectal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MLH1 MSH2

Biological processes related to Rectal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.58 HRAS KRAS TP53
2 determination of adult lifespan GO:0008340 9.48 MSH2 TP53
3 pyrimidine nucleoside catabolic process GO:0046135 9.46 DPYD TYMP
4 positive regulation of isotype switching to IgG isotypes GO:0048304 9.43 MLH1 MSH2
5 response to isolation stress GO:0035900 9.37 HRAS KRAS
6 positive regulation of isotype switching to IgA isotypes GO:0048298 9.32 MLH1 MSH2
7 pyrimidine nucleobase metabolic process GO:0006206 9.26 TYMP TYMS
8 somatic recombination of immunoglobulin gene segments GO:0016447 9.16 MLH1 MSH2
9 intrinsic apoptotic signaling pathway GO:0097193 9.13 APAF1 HRAS TP53
10 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MLH1 MSH2

Molecular functions related to Rectal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 MLH1 MSH2
2 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH2

Sources for Rectal Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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