MCID: RCT018
MIFTS: 54

Rectal Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Rectal Neoplasm

MalaCards integrated aliases for Rectal Neoplasm:

Name: Rectal Neoplasm 12 76 15
Rectal Carcinoma 55 73
Rectal Neoplasms 44 73
Rectum Cancer 12 15
Rectal Cancer 12 55
Malignant Neoplasm of Rectum 12
Malignant Tumor of Rectum 12
Malignant Rectal Neoplasm 73
Adenocarcinoma of Rectum 73
Carcinoma of the Rectum 12
Malignant Rectal Tumor 12
Malignant Rectum Tumor 12
Neoplasm of the Rectum 29
Carcinoma of Rectum 12
Neoplasm of Rectum 12
Cancer of Rectum 12
Rectum Neoplasm 12
Rectal Tumors 73
Rectal Tumor 12

Classifications:



Summaries for Rectal Neoplasm

Disease Ontology : 12 A colorectal cancer that is located in the rectum.

MalaCards based summary : Rectal Neoplasm, also known as rectal carcinoma, is related to lynch syndrome and rectum adenocarcinoma. An important gene associated with Rectal Neoplasm is TYMS (Thymidylate Synthetase), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Erbitux and Iron have been mentioned in the context of this disorder. Affiliated tissues include the rectum, colon and liver, and related phenotypes are digestive/alimentary and neoplasm

Wikipedia : 76 Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from... more...

Related Diseases for Rectal Neoplasm

Diseases related to Rectal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 lynch syndrome 32.1 KRAS MLH1 MSH2 TP53
2 rectum adenocarcinoma 31.5 CAGE1 CEACAM5 KRT20 KRT7 SLC14A2
3 familial adenomatous polyposis 30.4 KRAS MLH1 MSH2 TP53
4 adenoma 30.3 KRAS MLH1 MSH2 TP53
5 colorectal cancer 29.7 CEACAM5 DPYD HRAS KRAS KRT20 MLH1
6 rectal cancer, childhood 12.0
7 plantar wart 11.0 TP53 TYMS
8 mucoepidermoid esophageal carcinoma 11.0 CEACAM5 TP53
9 rectum sarcoma 11.0
10 rare adenocarcinoma of the breast 11.0 KRAS TP53
11 intracranial chondrosarcoma 11.0 CEACAM5 TP53
12 appendix carcinoid tumor 10.9 MLH1 MSH2
13 adenosquamous colon carcinoma 10.9 MLH1 MSH2
14 gastrointestinal carcinoma 10.9 DPYD KRT20 TYMS
15 cutaneous mucoepidermoid carcinoma 10.9 CEACAM5 KRT7
16 anal gland adenocarcinoma 10.9 CEACAM5 KRT7
17 cystic basal cell carcinoma 10.9 KRT20 KRT7
18 liver lymphoma 10.9 CEACAM5 SMUG1
19 splenic tuberculosis 10.9 CEACAM5 SMUG1
20 vaginal benign neoplasm 10.9 KRT20 KRT7
21 seminal vesicle adenocarcinoma 10.9 KRT20 KRT7
22 transverse colon cancer 10.9 KRT20 KRT7
23 appendix adenocarcinoma 10.9 KRT20 KRT7
24 ovarian large-cell neuroendocrine carcinoma 10.9 KRT20 KRT7
25 vaginal adenoma 10.9 KRT20 KRT7
26 sebaceous adenoma 10.9 MLH1 MSH2
27 vaginal tubulovillous adenoma 10.9 KRT20 KRT7
28 mucinous adenofibroma 10.8 CEACAM5 KRT7
29 anus adenocarcinoma 10.8 CEACAM5 KRT7
30 lower lip cancer 10.8 MLH1 MSH2
31 sigmoid neoplasm 10.8 CEACAM5 HRAS KRAS
32 eyelid neoplasm 10.8 KRT20 KRT7
33 glandular cystitis 10.8 KRT20 KRT7
34 microinvasive gastric cancer 10.8 CEACAM5 MLH1 TYMP
35 apocrine adenoma 10.8 CEACAM5 HRAS KRAS
36 aggressive digital papillary adenocarcinoma 10.8 CEACAM5 HRAS KRAS
37 actinic cheilitis 10.8 MSH2 TP53
38 schimmelpenning-feuerstein-mims syndrome 10.8 HRAS KRAS
39 malignant syringoma 10.8 KRT20 KRT7
40 ovary serous adenocarcinoma 10.8 CEACAM5 HRAS KRAS
41 ovarian cystadenocarcinoma 10.8 CEACAM5 HRAS KRAS
42 periampullary adenoma 10.8 HRAS KRAS
43 krukenberg carcinoma 10.8 KRT20 KRT7
44 vulval paget's disease 10.8 CEACAM5 KRT20 KRT7
45 bartholin's duct cyst 10.8 SMUG1 TP53
46 bile duct cystadenocarcinoma 10.8 CEACAM5 KRT20 KRT7
47 appendix cancer 10.8 KRAS KRT20 KRT7
48 thymus adenocarcinoma 10.8 CEACAM5 KRT20 KRT7
49 meibomian cyst 10.8 CEACAM5 KRT20 KRT7
50 hyperplastic polyposis syndrome 10.8 KRAS TP53

Comorbidity relations with Rectal Neoplasm via Phenotypic Disease Network (PDN): (show all 12)


Active Peptic Ulcer Disease Acute Cystitis
Anus Cancer Colorectal Cancer
Deficiency Anemia Hydronephrosis
Intestinal Obstruction Neutropenia
Paralytic Ileus Protein-Energy Malnutrition
Rectosigmoid Junction Neoplasm Rectum Carcinoma in Situ

Graphical network of the top 20 diseases related to Rectal Neoplasm:



Diseases related to Rectal Neoplasm

Symptoms & Phenotypes for Rectal Neoplasm

MGI Mouse Phenotypes related to Rectal Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 MSH2 TP53 APAF1 HRAS KRAS MLH1
2 neoplasm MP:0002006 9.23 MSH2 SMUG1 TP53 APAF1 HRAS KRAS

Drugs & Therapeutics for Rectal Neoplasm

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Erbitux 18 49 CETUXIMAB Imclone, Bristol-Myers Squibb February 2004

Drugs for Rectal Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 381)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
3
Udenafil Approved, Investigational Phase 4,Phase 2 268203-93-6 6918523
4
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
6
Menthol Approved Phase 4,Phase 2,Phase 1,Not Applicable 2216-51-5 16666
7
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
8
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2 93-14-1 3516
9
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
10
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
11
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
12
Acetaminophen Approved Phase 4 103-90-2 1983
13
Bupivacaine Approved, Investigational Phase 4,Not Applicable 2180-92-9, 38396-39-3 2474
14
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
15
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
16
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
17
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
18
Methadone Approved Phase 4 76-99-3 4095
19
Morphine Approved, Investigational Phase 4 57-27-2 5288826
20
Orphenadrine Approved Phase 4 83-98-7 4601
21
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
22
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
23
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
24 Ferric Compounds Phase 4
25 Ferric oxide, saccharated Phase 4
26 Hematinics Phase 4,Phase 3,Phase 2,Phase 1
27 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Vasodilator Agents Phase 4,Phase 1,Phase 2
30 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Phosphodiesterase 5 Inhibitors Phase 4,Phase 2
32 Phosphodiesterase Inhibitors Phase 4,Phase 2
33 Sildenafil Citrate Phase 4 171599-83-0
34 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Adjuvants, Anesthesia Phase 4
37 Adrenergic Agents Phase 4,Phase 3
38 Adrenergic Agonists Phase 4
39 Adrenergic alpha-2 Receptor Agonists Phase 4
40 Adrenergic alpha-Agonists Phase 4
41 Analgesics Phase 4,Phase 2,Phase 1,Not Applicable
42 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 1,Not Applicable
43 Analgesics, Opioid Phase 4
44 Anesthetics, General Phase 4
45 Anesthetics, Intravenous Phase 4
46 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
47 Hypnotics and Sedatives Phase 4,Phase 1,Phase 2
48 Narcotics Phase 4
49 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 916)
# Name Status NCT ID Phase Drugs
1 Iron Therapy in Colo-Rectal Neoplasm and Iron Deficiency Anemia: Intravenous Iron Sucrose Versus Oral Ferrous Sulphate. Unknown status NCT00199277 Phase 4 i.v. iron sucrose;Oral iron
2 Early Intervention for Erectile Dysfunction After Laparoscopic Resection for Rectal Cancer Completed NCT01912586 Phase 4
3 Concentration of Ertapenem in Colorectal Tissue Completed NCT00535652 Phase 4 Ertapenem
4 Prospective Study of the Use of a Mesh to Prevent Parastomal Hernia After Laparoscopic Abdominoperineal Resection Completed NCT01722565 Phase 4
5 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed NCT01056913 Phase 4
6 The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer Completed NCT01421940 Phase 4 Placebo drug;Udenafil
7 The Effect of Dexmedetomidine on Postoperative Analgesia Completed NCT01373021 Phase 4 Fentanyl;Dexmedetomidine
8 Prospective Randomized Study of SILS Versus CLS for Rectal Cancer Completed NCT01579721 Phase 4
9 CHOICE: Communicating Health Options Through Information and Cancer Education Completed NCT00134589 Phase 4
10 Transanal Endoscopic Microsurgery Versus Endoscopic Submucosal Dissection For Large Rectal Adenomas Recruiting NCT01023984 Phase 4
11 Cancer and Anesthesia: Survival After Radical Surgery - a Comparison Between Propofol or Sevoflurane Anesthesia Recruiting NCT01975064 Phase 4 Propofol;Sevoflurane
12 Study of NOTES-TME Versus L-LAR in Rectal Cancer Recruiting NCT02550769 Phase 4
13 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery Recruiting NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
14 The Role of Indocyanine Green (ICG) Fluorescence Imaging on Anastomotic Leak in Robotic Colorectal Surgery Unknown status NCT02598414 Phase 2, Phase 3
15 Collagen Implant Compared to Gluteus Maximus Flap for Reconstruction of Pelvic Floor After ELAPE/EAPE in Rectal Cancer Unknown status NCT01347697 Phase 3
16 Neoadjuvant Radiotherapy Followed by Transanal Endoscopic Microsurgery for T1-T2 Extraperitoneal Rectal Cancer Unknown status NCT02127645 Phase 3
17 Randomized Controlled Trial to Evaluate High Tie Versus Low Tie of the Inferior Mesenteric Artery in Anterior Resection Unknown status NCT01861678 Phase 3
18 Short Term Outcomes of Laparoscopic Intersphincteric Resection for Low Rectal Cancer Unknown status NCT01836926 Phase 2, Phase 3
19 Preoperative Downstaging of Extraperitoneal T3 Rectal Cancer: XELOXRT Versus XELACRT. A Multicenter, Phase III Study Unknown status NCT01653301 Phase 3 XELAC RT;XELOX RT
20 VSL#3 Versus Placebo in Increasing the Pathological Major Response Rate in Patients With Rectal Cancer Unknown status NCT01579591 Phase 3
21 Simultaneous Integrated Boost Preoperative Radiotherapy for Rectum Cancer Unknown status NCT01224392 Phase 3
22 A Trial of High Intensity Versus Low Intensity Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Unknown status NCT01064999 Phase 2, Phase 3 Oxaliplatin;Capecitabine
23 The Randomised Study of Preoperative Radiotherapy With Consolidating Chemotherapy for Unresectable Rectal Cancer Unknown status NCT00833131 Phase 3
24 Preoperative Radiotherapy and Local Excision in Rectal Cancer Unknown status NCT00738790 Phase 3
25 A Randomized Controlled Clinical Trial Comparing Oncological Results and Functional Recovery Between Laparoscopic and Open Method for the Treatment of Advanced Rectal Cancer After Concurrent Chemoradiation Therapy (CCRT) Unknown status NCT00601549 Phase 3
26 Preoperative Chemoradiation Versus Short Term Radiation Alone With Delayed Surgery for Stage II and III Resectable Rectal Cancer Unknown status NCT00597311 Phase 3
27 Randomized Prospective Trial for Laparoscopic vs Open Resection for Rectal Cancer Unknown status NCT00470951 Phase 3
28 COLOR II: Laparoscopic Versus Open Rectal Cancer Removal Unknown status NCT00297791 Phase 3
29 5FU/VL Vs LV5FU2 + CPT11 in Stage II-III Resected Rectal Cancer Unknown status NCT00189657 Phase 3
30 Laparoscopic Anterior Resection With or Without "Dog Ear" Double-stapled Anastomosis for Rectal Cancer Unknown status NCT02770911 Phase 3
31 Resource-Sparing Curative Treatment for Rectal Cancer Unknown status NCT01459328 Phase 3
32 Randomized Trial on Robotic Assisted Resection for Rectal Cancer Unknown status NCT01130233 Phase 3
33 Concurrent Chemoradiation Versus Wide Pelvic Lymphadenectomy for Advanced Rectal Cancer Unknown status NCT00154752 Phase 3
34 Comparison of Two Types of Surgery in Treating Patients With Rectal Cancer Unknown status NCT00007930 Phase 3
35 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3 cisplatin;fluorouracil
36 Local Excision in Downstaged Rectal Cancer Completed NCT00427375 Phase 3
37 Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy With 5-Fluorouracil and Oxaliplatin Versus 5-Fluorouracil Alone in Rectal Cancer Completed NCT00349076 Phase 3 5-FU and oxaliplatin;5-FU
38 Mesorectal Excision (ME) Versus ME With Lateral Node Dissection for Stage II, III Lower Rectal Cancer (JCOG0212) Completed NCT00190541 Phase 3
39 Capecitabine Versus Bolus 5-Fu Associated to Radiotherapy as Neoadjuvant Treatment for Rectal Cancer. Completed NCT03428529 Phase 2, Phase 3 Capecitabine Oral Product;5Fluorouracil
40 Efficiency of Two Dimensional High Definition Versus Three Dimensional Endoscopic Systems in Transanal Endoscopic Surgery Completed NCT01498354 Phase 3
41 Study of the Efficacy and Safety of Epoetin Alfa Administered Weekly in Patients With Gastric or Rectal Cancers Undergoing a Treatment Plan of Preoperative Chemotherapy and Radiation Therapy, Followed by Surgery Completed NCT00036400 Phase 3 epoetin alfa
42 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Metastatic Colorectal Cancer. Completed NCT00056459 Phase 3 Vatalanib
43 Study of Oxaliplatin/5-FU/Leucovorin Plus Vatalanib Versus Oxaliplatin/5-FU/Leucovorin in Patients With Previously Treated Metastatic Colorectal Cancer Completed NCT00056446 Phase 3 Vatalanib
44 Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB Completed NCT00236249 Phase 3 Lidocaine
45 ELRR by TEM Versus Laparoscopic TME in iT2N0M0 SMALL LOW RECTAL CANCER Completed NCT01609504 Phase 3
46 Capecitabine in the Perioperative Treatment of Rectal Cancer Completed NCT01500993 Phase 3 Capecitabine;5-FU
47 Randomized Clinical Trial on Preoperative Radiotherapy 25 Gy in Rectal Cancer Completed NCT01444495 Phase 3
48 Drainage After Rectal Excision for Rectal Cancer Completed NCT01269567 Phase 3
49 Comparison of Preoperative and Postoperative Radiotherapy and Capecitabine in Locally Advanced Rectal Cancer Completed NCT01186081 Phase 3
50 Modulation of Adjuvant 5-FU by Folinic Acid and Interferon-alpha in Colon Cancer Completed NCT01060501 Phase 3 Folinic Acid, interferon-alpha

Search NIH Clinical Center for Rectal Neoplasm

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: rectal neoplasms

Genetic Tests for Rectal Neoplasm

Genetic tests related to Rectal Neoplasm:

# Genetic test Affiliating Genes
1 Neoplasm of the Rectum 29

Anatomical Context for Rectal Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Rectal Neoplasm:

19
The Rectum

MalaCards organs/tissues related to Rectal Neoplasm:

41
Colon, Liver, Lymph Node, Testes, Lung, Brain, Prostate

Publications for Rectal Neoplasm

Articles related to Rectal Neoplasm:

(show all 15)
# Title Authors Year
1
Pancreatic solid pseudopapillary neoplasm as an incidental discovery in a patient with rectal neoplasm. ( 28338106 )
2017
2
Endoscopic submucosal dissection of an unusual flat rectal neoplasm. ( 25320106 )
2014
3
Phantom rectum following abdominoperineal excision for rectal neoplasm: appearance and disappearance. ( 23746116 )
2013
4
Images of the month: heterotopic gastric mucosa mimicking rectal neoplasm on colonoscopy. ( 23552305 )
2013
5
Hybrid transanal endoscopic microsurgery: a novel approach to rectal neoplasm excision. ( 24118673 )
2013
6
Excision of a rectal neoplasm using robotic transanal surgery (RTS): a description of the technique. ( 22584407 )
2012
7
The significant rectal neoplasm and mucosectomy by transanal endoscopic microsurgery. ( 21633951 )
2011
8
The significant rectal neoplasm and mucosectomy by transanal endoscopic microsurgery (Br J Surg 2011; 98: 1342-1344). ( 21887781 )
2011
9
Postradiotherapy regression--a prognostic factor in rectal neoplasm. ( 22308912 )
2011
10
Solitary rectal ulcer syndrome mimicking rectal neoplasm on MRI. ( 20965892 )
2010
11
Early outcomes of 100 patients with laparoscopic resection for rectal neoplasm. ( 15931488 )
2004
12
Mass screening for rectal neoplasm in Jiashan County, China. ( 1753269 )
1991
13
Pre-operative staging of rectal neoplasm and its impact on clinical management. ( 4063751 )
1985
14
Granular-cell myoblastoma--an unusual rectal neoplasm. Report of a case. ( 4304580 )
1969
15
Sigmoidorectal prolapse simulating rectal neoplasm. ( 13871441 )
1962

Variations for Rectal Neoplasm

Copy number variations for Rectal Neoplasm from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 139647 2 185171337 185512459 Copy number ZNF804A Rectal cancer
2 166960 3 1109627 1420278 Copy number CNTN6 Rectal cancer
3 225401 7 45400000 54000000 Copy number EGFR Rectal cancer

Expression for Rectal Neoplasm

Search GEO for disease gene expression data for Rectal Neoplasm.

Pathways for Rectal Neoplasm

Pathways related to Rectal Neoplasm according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.68 HRAS KRAS MLH1 MSH2 TP53
2 12.52 APAF1 HRAS KRAS MLH1 MSH2 TP53
3 12.24 DPYD MLH1 MSH2 TP53 TYMS
4
Show member pathways
11.94 APAF1 HRAS KRAS TP53
5 11.83 APAF1 MLH1 MSH2 TP53
6 11.57 KRAS MLH1 MMP7 MSH2 TP53
7
Show member pathways
11.51 APAF1 MMP7 TP53
8 11.48 HRAS KRAS TP53
9 11.47 HRAS KRAS TP53
10 11.42 HRAS KRAS TP53 TYMP
11 11.32 APAF1 MLH1 MSH2 TP53
12
Show member pathways
11.21 MLH1 MSH2 TP53
13
Show member pathways
11.15 DPYD SMUG1 TP53 TYMP TYMS
14 11.14 HRAS KRAS TP53
15 10.64 HRAS KRAS

GO Terms for Rectal Neoplasm

Cellular components related to Rectal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MLH1 MSH2

Biological processes related to Rectal Neoplasm according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 Ras protein signal transduction GO:0007265 9.61 HRAS KRAS TP53
2 isotype switching GO:0045190 9.49 MLH1 MSH2
3 determination of adult lifespan GO:0008340 9.48 MSH2 TP53
4 pyrimidine nucleoside catabolic process GO:0046135 9.46 DPYD TYMP
5 positive regulation of isotype switching to IgG isotypes GO:0048304 9.4 MLH1 MSH2
6 pyrimidine nucleobase metabolic process GO:0006206 9.37 TYMP TYMS
7 response to isolation stress GO:0035900 9.32 HRAS KRAS
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.26 MLH1 MSH2
9 somatic recombination of immunoglobulin gene segments GO:0016447 9.16 MLH1 MSH2
10 intrinsic apoptotic signaling pathway GO:0097193 9.13 APAF1 HRAS TP53
11 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MLH1 MSH2

Molecular functions related to Rectal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 MLH1 MSH2
2 guanine/thymine mispair binding GO:0032137 8.62 MLH1 MSH2

Sources for Rectal Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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