MCID: RCT009
MIFTS: 37

Rectosigmoid Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Rectosigmoid Cancer

MalaCards integrated aliases for Rectosigmoid Cancer:

Name: Rectosigmoid Cancer 12 15
Malignant Neoplasm of Rectosigmoid Junction 12 32
Rectosigmoid Junction Cancer 12 15
Malignant Tumor of Rectosigmoid Junction 12
Malignant Neoplasm of Rectosigmoid 12
Malignant Rectosigmoid Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2781 DOID:2782
ICD9CM 34 154.0
NCIt 50 C7420 C7421
SNOMED-CT 67 363414004
ICD10 32 C19
UMLS 70 C0153443 C1327709

Summaries for Rectosigmoid Cancer

MalaCards based summary : Rectosigmoid Cancer, also known as malignant neoplasm of rectosigmoid junction, is related to rectosigmoid junction neoplasm and rectum cancer. An important gene associated with Rectosigmoid Cancer is CEACAM5 (CEA Cell Adhesion Molecule 5), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Cell surface interactions at the vascular wall. Affiliated tissues include colon, lung and ovary, and related phenotypes are Reduced mammosphere formation and neoplasm

Related Diseases for Rectosigmoid Cancer

Diseases related to Rectosigmoid Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 rectosigmoid junction neoplasm 32.6 KRAS CEACAM5
2 rectum cancer 29.8 MUTYH MSH6 KRAS HRAS CEACAM5
3 mucinous adenocarcinoma 29.6 KRAS CEACAM5 CDX2
4 appendix adenocarcinoma 29.5 KRAS HRAS CDX2
5 colon adenocarcinoma 29.4 PMS2 MSH6 KRAS CEACAM5
6 cholangiocarcinoma 29.3 KRAS CEACAM5 CDX2
7 adenocarcinoma 28.8 POLE MSH6 KRAS HRAS CEACAM5 CDX2
8 colorectal adenocarcinoma 28.5 PMS2 MSH6 KRAS HRAS CEACAM5 CDX2
9 mature teratoma 10.3 KRAS CEACAM5
10 pancreatic cystadenocarcinoma 10.3 KRAS CEACAM5
11 urachal adenocarcinoma 10.3 KRAS CEACAM5
12 bile acid synthesis defect, congenital, 5 10.3 KRAS CEACAM5
13 hepatic flexure cancer 10.3 KRAS HRAS
14 trachea carcinoma in situ 10.3 KRAS HRAS
15 cobblestone retinal degeneration 10.3 KRAS HRAS
16 pancreatic signet ring cell adenocarcinoma 10.2 KRAS HRAS
17 polymerase proofreading-related adenomatous polyposis 10.2 POLE POLD1
18 ampulla of vater benign neoplasm 10.2 KRAS HRAS
19 rectum signet ring adenocarcinoma 10.2 PMS2 CEACAM5
20 bone giant cell sarcoma 10.2 KRAS HRAS
21 acneiform dermatitis 10.2 KRAS HRAS
22 gallbladder benign neoplasm 10.2 KRAS HRAS
23 adenosquamous lung carcinoma 10.2 KRAS HRAS
24 mucinous lung adenocarcinoma 10.2 KRAS HRAS
25 wolffian duct adenocarcinoma 10.2 KRAS HRAS
26 noonan syndrome-like disorder with loose anagen hair 1 10.2 KRAS HRAS
27 noonan syndrome-like disorder with loose anagen hair 10.2 KRAS HRAS
28 pancreatic acinar cell adenocarcinoma 10.2 KRAS HRAS
29 ovarian benign neoplasm 10.2 HRAS CEACAM5
30 paronychia 10.2 KRAS HRAS
31 lung carcinoma in situ 10.2 KRAS HRAS
32 vulvar disease 10.2 HRAS CEACAM5
33 core binding factor acute myeloid leukemia 10.2 KRAS HRAS
34 pulmonary adenocarcinoma in situ 10.2 KRAS HRAS
35 oculoectodermal syndrome 10.2 KRAS HRAS
36 large intestine adenocarcinoma 10.2 KRAS HRAS
37 lung non-squamous non-small cell carcinoma 10.1 KRAS HRAS
38 myasthenic syndrome, congenital, 14 10.1 KRAS HRAS
39 signet ring basal cell carcinoma 10.1 KRAS HRAS CEACAM5
40 immature teratoma of ovary 10.1 KRAS HRAS CEACAM5
41 biliary tract benign neoplasm 10.1 KRAS HRAS CEACAM5
42 extrahepatic bile duct adenoma 10.1 PMS2 MSH6
43 bile duct cysts 10.1 KRAS HRAS CEACAM5
44 papillary adenoma 10.1 KRAS HRAS CEACAM5
45 eccrine papillary adenoma 10.1 KRAS HRAS CEACAM5
46 anus cancer 10.1 KRAS HRAS CEACAM5
47 papillary serous adenocarcinoma 10.1 KRAS HRAS CEACAM5
48 reproductive organ benign neoplasm 10.1 KRAS HRAS CEACAM5
49 large intestine lipoma 10.1 MUTYH CEACAM5
50 appendix carcinoid tumor 10.1 PMS2 MSH6

Graphical network of the top 20 diseases related to Rectosigmoid Cancer:



Diseases related to Rectosigmoid Cancer

Symptoms & Phenotypes for Rectosigmoid Cancer

GenomeRNAi Phenotypes related to Rectosigmoid Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 HRAS KRAS MUTYH POLD1 POLE

MGI Mouse Phenotypes related to Rectosigmoid Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.23 CDX2 HRAS KRAS MSH6 MUTYH PMS2

Drugs & Therapeutics for Rectosigmoid Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Role of CD133 and Microsatellite Status in Evaluation of Young Adults With Rectosigmoid Cancer Received Neoadjuvant Treatment Unknown status NCT03002727
2 A Perspective Study to Compare the Tubeless NOSES and Traditional Laparoscopic Radical Resection in Rectosigmoid Cancers (CORNER) Recruiting NCT04037956

Search NIH Clinical Center for Rectosigmoid Cancer

Genetic Tests for Rectosigmoid Cancer

Anatomical Context for Rectosigmoid Cancer

MalaCards organs/tissues related to Rectosigmoid Cancer:

40
Colon, Lung, Ovary, Appendix, Small Intestine, Lymph Node, Thyroid

Publications for Rectosigmoid Cancer

Articles related to Rectosigmoid Cancer:

(show top 50) (show all 265)
# Title Authors PMID Year
1
Implantation of rectosigmoid cancer in a preexisting anal fissure. 61
33786288 2021
2
Robotic low anterior resection with total hysterectomy, bilateral salpingo-oophorectomy and en bloc pelvic peritonectomy followed by hyperthermic intraperitoneal chemotherapy for the multi-modal treatment of rectosigmoid cancer with peritoneal seeding - A video vignette. 61
33675572 2021
3
Comprehensive analysis of lncRNA-associated ceRNA network reveals the novel potential of lncRNA, miRNA and mRNA biomarkers in human rectosigmoid junction cancer. 61
33552263 2021
4
Pelvic local recurrence as first relapse predicts prognosis for clinical stage II/III lower rectal cancer: A clinicopathological investigation. 61
33414914 2021
5
Does the Endoscopic Surgical Skill Qualification System improve patients' outcome following laparoscopic surgery for colon cancer? A multicentre, retrospective analysis with propensity score matching. 61
33608034 2021
6
Is early anvil placement an alternative technique to reduce anastomotic leak after rectosigmoid cancer resection? 61
33576338 2021
7
Germline HOXB13 G84E mutation carriers and risk to twenty common types of cancer: results from the UK Biobank. 61
32830201 2020
8
Changes in colorectal cancer incidence by site and age from 1973 to 2015: a SEER database analysis. 61
33025301 2020
9
Three-trocar tubeless natural orifice specimen extraction surgery in rectosigmoid cancer - a video vignette. 61
32336013 2020
10
Preservation of Inferior Mesenteric Vessels. Laparoscopic Sigmoidectomy for Cancer - a video vignette. 61
32810899 2020
11
Laparoscopic vs. Open Surgery for Stage II/III Colon Cancer Patients With Body Mass Index >25 kg/m2. 61
32606186 2020
12
Colorectal Intussusception Due to Rectosigmoid Junction Cancer: A Unique Surgical Challenge? 61
31713812 2020
13
Robotic multivisceral resection for a locally advanced rectosigmoid cancer - a video vignette. 61
31965699 2020
14
The effect of primary tumor radiotherapy in patients with Unresectable stage IV Rectal or Rectosigmoid Cancer: a propensity score matching analysis for survival. 61
32460810 2020
15
Patterns of Care for Stage II-III Rectosigmoid Cancers in the United States, 2004-2015. 61
32235162 2020
16
Low rate of local recurrence detection by rectoscopy in follow-up of rectal cancer. 61
31556190 2020
17
Laparoscopic liver resection of segment seven: A case report and review of surgical techniques. 61
32688239 2020
18
Prognostic Impact of the Length of the Distal Resection Margin in Rectosigmoid Cancer: An Analysis of the JSCCR Database between 1995 and 2004. 61
32346644 2020
19
Multi-Institutional Analysis of Synchronous Prostate and Rectosigmoid Cancers. 61
32266135 2020
20
Covid-19 mimicking symptoms in emergency gastrointestinal surgery cases during pandemic: A case series. 61
33137666 2020
21
Tubeless natural orifice specimen extraction surgery in rectosigmoid cancer - a video vignette. 61
31444922 2020
22
Paraneoplastic pyoderma gangrenosum associated with adenocarcinoma of the rectosigmoid junction: a case report. 61
31810486 2019
23
[Curative Resection for Liver Metastasis Ten Years after Surgery for Rectosigmoid Cancer-A Case Report]. 61
32156935 2019
24
[A Case of Early Rectal Cancer Recurring as Liver Metastasis Nine Months after ESD]. 61
32156906 2019
25
A germline MBD4 mutation was identified in a patient with colorectal oligopolyposis and early‑onset cancer: A case report. 61
31322271 2019
26
[A Case of Curatively Resected Rectosigmoid Colon Cancer That Invaded the Urinary Bladder after Neoadjuvant Chemotherapy]. 61
31189822 2019
27
Short-term outcomes of single-incision plus one-port laparoscopic versus conventional laparoscopic surgery for rectosigmoid cancer: a randomized controlled trial. 61
30006846 2019
28
Preservation of left colic artery with lymph node dissection of IMA root during laparoscopic surgery for rectosigmoid cancer. Results of a retrospective analysis. 61
30993308 2019
29
[A Case of Rectosigmoid Cancer with Intestinal Malrotation Treated with Laparoscopic Surgery]. 61
30692429 2018
30
Mortality From Postscreening (Interval) Colorectal Cancers Is Comparable to That From Cancer in Unscreened Patients-A Randomized Sigmoidoscopy Trial. 61
30165051 2018
31
Laparoscopic-Assisted Resection for Advanced Colorectal Cancer in Solid Organ Transplant Recipients. 61
28925783 2018
32
Colonic ischemia developed after laparoscopic colectomy for rectosigmoid cancer with focal infrarenal aortic stenosis. 61
29316285 2018
33
Impact of Left Colonic Artery Preservation on Anastomotic Leakage in Laparoscopic Sigmoid Resection and Anterior Resection for Sigmoid and Rectosigmoid Colon Cancer. 61
29987526 2018
34
Incidence of suspicious axillary lymph node involvement in fluorine-18 fluoro-D-glucose positron emission tomography/computed tomography in gynecologic cancers. 61
29971187 2018
35
Laparoscopic surgery for locally advanced T4 colon cancer: the long-term outcomes and prognostic factors. 61
29288349 2018
36
Age-related rates of colorectal cancer and the factors associated with overall survival. 61
29564176 2018
37
Using indocyanine green fluorescent imaging to successfully resect metachronous regional lymph node recurrence of rectosigmoid cancer. 61
28703406 2018
38
Primary splenic malignant lymphoma mimicking metastasis of rectosigmoid cancer: A case report. 61
29462751 2018
39
Surgical outcomes of robot-assisted rectal cancer surgery using the da Vinci Surgical System: a multi-center pilot Phase II study. 61
29036613 2017
40
A New Prediction Model for Local Recurrence After Curative Rectal Cancer Surgery: Development and Validation as an Asian Collaborative Study. 61
28991081 2017
41
[Two Cases of Achieving a Pathological Complete Response via Hepatic Arterial Infusion Chemotherapy for Liver-Limited and Unresectable Liver Metastases from Colorectal Cancer with RAS Mutations]. 61
29394623 2017
42
[A Case of Bladder Metastasis Occurring after Rectosigmoid Cancer Operation]. 61
29394653 2017
43
Validation of an online risk calculator for the prediction of anastomotic leak after colon cancer surgery and preliminary exploration of artificial intelligence-based analytics. 61
29080956 2017
44
Necrotising fasciitis in a patient treated with FOLFIRI-aflibercept for colorectal cancer: a case report. 61
28768426 2017
45
Intraluminal rectal cancer metastasis to the small bowel: An extremely rare case report. 61
29046790 2017
46
Disparities in the Age-Related Rates of Colorectal Cancer in the United States. 61
28637568 2017
47
Assessment of treatment options for rectosigmoid cancer: single-incision plus one port laparoscopic surgery, single-incision laparoscopic surgery, and conventional laparoscopic surgery. 61
27709329 2017
48
Unusual presentation of advanced prostate cancer masquerading as metastatic and obstructing rectosigmoid cancer. 61
25388794 2017
49
Circulating tumor cells in different stages of colorectal cancer. 61
28509310 2017
50
Associating liver partition and portal vein ligation for staged hepatectomy: A surgical technique for liver resections. 61
28567071 2017

Variations for Rectosigmoid Cancer

Expression for Rectosigmoid Cancer

Search GEO for disease gene expression data for Rectosigmoid Cancer.

Pathways for Rectosigmoid Cancer

Pathways related to Rectosigmoid Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 POLE POLD1 PMS2 MUTYH MSH6
2
Show member pathways
11.86 KRAS HRAS CEACAM5
3 11.04 KRAS HRAS
4 10.99 KRAS HRAS
5 10.97 KRAS HRAS
6 10.94 PMS2 MSH6
7
Show member pathways
10.92 KRAS HRAS
8
Show member pathways
10.9 POLE POLD1 PMS2 MSH6
9 10.77 KRAS HRAS
10 10.71 KRAS HRAS
11 10.62 KRAS HRAS
13 10.07 KRAS HRAS

GO Terms for Rectosigmoid Cancer

Cellular components related to Rectosigmoid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 PMS2 MSH6

Biological processes related to Rectosigmoid Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.65 POLE POLD1 PMS2 MUTYH MSH6
2 nucleic acid phosphodiester bond hydrolysis GO:0090305 9.63 POLE POLD1 PMS2
3 DNA repair GO:0006281 9.55 POLE POLD1 PMS2 MUTYH MSH6
4 intrinsic apoptotic signaling pathway GO:0097193 9.52 MSH6 HRAS
5 telomere maintenance via semi-conservative replication GO:0032201 9.51 POLE POLD1
6 nucleotide-excision repair, DNA gap filling GO:0006297 9.49 POLE POLD1
7 regulation of long-term neuronal synaptic plasticity GO:0048169 9.48 KRAS HRAS
8 somatic hypermutation of immunoglobulin genes GO:0016446 9.43 PMS2 MSH6
9 DNA synthesis involved in DNA repair GO:0000731 9.4 POLE POLD1
10 response to isolation stress GO:0035900 9.37 KRAS HRAS
11 base-excision repair, gap-filling GO:0006287 9.32 POLE POLD1
12 DNA replication proofreading GO:0045004 8.96 POLE POLD1
13 mismatch repair GO:0006298 8.92 POLD1 PMS2 MUTYH MSH6

Molecular functions related to Rectosigmoid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.88 POLE POLD1 PMS2 MUTYH KRAS HRAS
2 DNA-directed DNA polymerase activity GO:0003887 9.43 POLE POLD1
3 mismatched DNA binding GO:0030983 9.37 PMS2 MSH6
4 MutSalpha complex binding GO:0032407 9.32 PMS2 MUTYH
5 MutLalpha complex binding GO:0032405 9.26 MUTYH MSH6
6 oxidized purine DNA binding GO:0032357 9.16 MUTYH MSH6
7 iron-sulfur cluster binding GO:0051536 9.13 POLE POLD1 MUTYH
8 4 iron, 4 sulfur cluster binding GO:0051539 8.8 POLE POLD1 MUTYH

Sources for Rectosigmoid Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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