MCID: RCT009
MIFTS: 49

Rectosigmoid Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Rectosigmoid Cancer

MalaCards integrated aliases for Rectosigmoid Cancer:

Name: Rectosigmoid Cancer 12 15
Rectosigmoid Junction Cancer 12 15
Malignant Neoplasm of Rectosigmoid Junction 12
Malignant Tumor of Rectosigmoid Junction 12
Malignant Neoplasm of Rectosigmoid 12
Malignant Rectosigmoid Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2781 DOID:2782
ICD9CM 36 154.0
NCIt 51 C7420 C7421
SNOMED-CT 69 93980002
ICD10 34 C19

Summaries for Rectosigmoid Cancer

MalaCards based summary : Rectosigmoid Cancer, also known as rectosigmoid junction cancer, is related to rectosigmoid junction neoplasm and ovarian cancer. An important gene associated with Rectosigmoid Cancer is CTSL (Cathepsin L), and among its related pathways/superpathways are PAK Pathway and PI3K-Akt signaling pathway. The drugs Capecitabine and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon, prostate and ovary, and related phenotypes are Increased cell migration and Reduced mammosphere formation

Related Diseases for Rectosigmoid Cancer

Diseases related to Rectosigmoid Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 rectosigmoid junction neoplasm 32.9 CTSL DCXR KRAS
2 ovarian cancer 28.6 CTNNB1 FASLG KRAS MAPK1 MLH1 MSH2
3 breast cancer 27.6 CEACAM5 CTNNB1 HRAS IL6 KRAS MAPK1
4 cold agglutinin disease 10.4 CRP IL6
5 periampullary adenoma 10.3 HRAS KRAS
6 paronychia 10.3 HRAS KRAS
7 schimmelpenning-feuerstein-mims syndrome 10.3 HRAS KRAS
8 arteriovenous malformations of the brain 10.3 ENG IL6 KRAS
9 neurofibromatosis, type iv, of riccardi 10.3 HRAS MSH6 PMS2
10 intussusception 10.2 CRP ENG IL6
11 carcinosarcoma 10.2 CTNNB1 HRAS KRAS
12 spindle cell intraocular melanoma 10.2 MLH1 PMS2
13 louse-borne relapsing fever 10.2 CRP IL6 MAPK1
14 exanthem 10.2 CRP HRAS IL6 KRAS
15 pancreas disease 10.2 CRP HRAS IL6 KRAS
16 lacrimal apparatus disease 10.2 DCXR IL10 IL6
17 eye lymphoma 10.1 IL10 IL6
18 myeloma, multiple 10.1 CRP HRAS IL6 KRAS
19 multicentric castleman disease 10.1 CRP IL10 IL6
20 castleman disease 10.1 CRP IL10 IL6
21 prostate cancer 10.1
22 prostate cancer, hereditary, 8 10.1
23 prostate cancer, hereditary, 6 10.1
24 gallbladder adenoma 10.1 CTNNB1 HRAS
25 mycoplasma pneumoniae pneumonia 10.1 CRP IL10 IL6
26 acute pyelonephritis 10.1 CRP IL10 IL6
27 pyelonephritis 10.1 CRP IL10 IL6
28 extrinsic cardiomyopathy 10.1 CRP IL10 IL6
29 lymph node disease 10.1 CRP IL10 IL6
30 leptospirosis 10.1 CRP IL10 IL6
31 brucellosis 10.1 CRP IL10 IL6
32 appendicitis 10.1 CRP IL10 IL6
33 autoimmune disease of musculoskeletal system 10.1 CRP IL10 IL6
34 bacterial meningitis 10.1 CRP IL10 IL6
35 meningitis 10.1 CRP IL10 IL6
36 primary bacterial infectious disease 10.1 CRP IL10 IL6
37 gastroenteritis 10.1 CRP IL10 IL6
38 endocarditis 10.1 CRP IL10 IL6
39 bone inflammation disease 10.1 CRP IL10 IL6
40 chlamydia 10.1 CRP IL10 IL6
41 urachal adenocarcinoma 10.0 CEACAM5 KRAS
42 idiopathic neutropenia 10.0 FASLG IL10 IL6
43 bronchiolitis 10.0 CRP IL10 IL6
44 reproductive system disease 10.0 CTNNB1 IL6 MLH1
45 peritonitis 10.0 CRP IL10 IL6
46 colorectal cancer, hereditary nonpolyposis, type 7 10.0 MLH1 MSH2
47 sigmoid neoplasm 10.0 CEACAM5 HRAS KRAS
48 anal gland adenocarcinoma 10.0 CEACAM5 CRP
49 apocrine adenoma 10.0 CEACAM5 HRAS KRAS
50 proteasome-associated autoinflammatory syndrome 1 10.0 CRP IL10 IL6

Graphical network of the top 20 diseases related to Rectosigmoid Cancer:



Diseases related to Rectosigmoid Cancer

Symptoms & Phenotypes for Rectosigmoid Cancer

GenomeRNAi Phenotypes related to Rectosigmoid Cancer according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell migration GR00055-A-3 9.26 CTNNB1 HRAS KRAS MAPK1
2 Reduced mammosphere formation GR00396-S 9.17 CTSL DCXR FASLG HRAS KRAS MAPK1

MGI Mouse Phenotypes related to Rectosigmoid Cancer:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 CRP CTNNB1 ENG FASLG HRAS IL10
2 digestive/alimentary MP:0005381 10.27 CTNNB1 ENG FASLG HRAS IL10 IL6
3 cellular MP:0005384 10.25 CTNNB1 FASLG IL10 IL6 KRAS MAPK1
4 hematopoietic system MP:0005397 10.23 CTNNB1 ENG FASLG IL10 IL6 KRAS
5 cardiovascular system MP:0005385 10.22 CRP CTNNB1 ENG FASLG HRAS IL10
6 immune system MP:0005387 10.18 CRP CTNNB1 FASLG IL10 IL6 KRAS
7 endocrine/exocrine gland MP:0005379 10.13 CTNNB1 FASLG HRAS IL10 IL6 KRAS
8 integument MP:0010771 10.11 CTNNB1 ENG FASLG HRAS IL10 IL6
9 mortality/aging MP:0010768 10.07 CTNNB1 ENG FASLG HRAS IL10 IL6
10 neoplasm MP:0002006 9.93 CTNNB1 FASLG HRAS IL10 IL6 KRAS
11 liver/biliary system MP:0005370 9.87 CTNNB1 FASLG IL10 IL6 KRAS MAPK1
12 respiratory system MP:0005388 9.61 CTNNB1 ENG FASLG HRAS IL10 IL6
13 vision/eye MP:0005391 9.23 CTNNB1 FASLG IL10 IL6 KRAS MAPK1

Drugs & Therapeutics for Rectosigmoid Cancer

Drugs for Rectosigmoid Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 4 154361-50-9 60953
2 Cola Phase 4,Phase 3,Phase 2,Not Applicable
3 Antimetabolites Phase 4
4 Antimetabolites, Antineoplastic Phase 4
5
Iodine Approved, Investigational Phase 3 7553-56-2 807
6
Povidone Approved Phase 3 9003-39-8
7
Povidone-iodine Approved Phase 3 25655-41-8
8 cadexomer iodine Phase 3
9
Fluorouracil Approved Phase 2 51-21-8 3385
10
leucovorin Approved Phase 2 58-05-9 143 6006
11
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Capecitabine (Xeloda) and Radiation for Patients With Rectosigmoid Carcinoma Terminated NCT00216424 Phase 4 Capecitabine (Xeloda)
2 Safety Study of Totally Laparoscopic Resection With Natural Orifice Specimen Extraction (NOSE) for Rectosigmoid Cancer Recruiting NCT02635503 Phase 3
3 Randomized Controlled Trial Between Laparoscopic and Open Surgery in Transverse and Descending Colon Cancer Patients Unknown status NCT01861691 Phase 2
4 mFOLFOX6 vs. mFOLFOX6 + Aflibercept as Neoadjuvant Treatment in MRI-defined T3-rectal Cancer Recruiting NCT03043729 Phase 2 Oxaliplatin;5-FU;Leucovorin
5 Peritoneal Microdialysis in Patients Undergoing Low Anterior Resection (LAR) for Recto-sigmoid Cancer Completed NCT00271986
6 Role of Low Inferior Mesenteric Artery Ligation During Laparoscopic Surgery for Rectosigmoid Cancer Completed NCT03557528
7 Role of CD133 & Microsatellite Status in Evaluation of Rectosigmoid Cancer Young Adults Received Neoadjuvant Treatment Recruiting NCT03002727
8 Circulating Tumor Cells in Patients With Rectal Cancer Recruiting NCT02874885
9 Personalized Dietary Intervention in Managing Bowel Dysfunction and Improving Quality of Life in Stage I-III Rectosigmoid Cancer Survivors Active, not recruiting NCT03063918 Not Applicable
10 A Study Assessing Perfusion Outcomes With PINPOINT® Near Infrared Fluorescence Imaging in Low Anterior Resection Terminated NCT02205307 Not Applicable

Search NIH Clinical Center for Rectosigmoid Cancer

Genetic Tests for Rectosigmoid Cancer

Anatomical Context for Rectosigmoid Cancer

MalaCards organs/tissues related to Rectosigmoid Cancer:

42
Colon, Prostate, Ovary, Lymph Node, Brain, Bone, Pancreas

Publications for Rectosigmoid Cancer

Articles related to Rectosigmoid Cancer:

(show top 50) (show all 68)
# Title Authors Year
1
Preservation of left colic artery with lymph node dissection of IMA root during laparoscopic surgery for rectosigmoid cancer. Results of a retrospective analysis. ( 30993308 )
2019
2
Using indocyanine green fluorescent imaging to successfully resect metachronous regional lymph node recurrence of rectosigmoid cancer. ( 28703406 )
2018
3
Colonic ischemia developed after laparoscopic colectomy for rectosigmoid cancer with focal infrarenal aortic stenosis. ( 29316285 )
2018
4
Primary splenic malignant lymphoma mimicking metastasis of rectosigmoid cancer: A case report. ( 29462751 )
2018
5
Short-term outcomes of single-incision plus one-port laparoscopic versus conventional laparoscopic surgery for rectosigmoid cancer: a randomized controlled trial. ( 30006846 )
2018
6
Unusual presentation of advanced prostate cancer masquerading as metastatic and obstructing rectosigmoid cancer. ( 25388794 )
2017
7
Assessment of treatment options for rectosigmoid cancer: single-incision plus one port laparoscopic surgery, single-incision laparoscopic surgery, and conventional laparoscopic surgery. ( 27709329 )
2017
8
Reduced Ovarian Cancer Incidence in Women Exposed to Low Dose Ionizing Background Radiation or Radiation to the Ovaries after Treatment for Breast Cancer or Rectosigmoid Cancer. ( 27356721 )
2016
9
Radiotherapy dose led to a substantial prolongation of survival in patients with locally advanced rectosigmoid junction cancer: a large population based study. ( 27070089 )
2016
10
Incidentally detected sigmoidovesical fistula in a case of rectosigmoid cancer detected on FDG PET-CT. ( 24999684 )
2015
11
Comparison of non-schistosomal rectosigmoid cancer and schistosomal rectosigmoid cancer. ( 26109809 )
2015
12
Single-site laparoscopic colectomy for rectosigmoid cancer with middle aortic syndrome: report of a case. ( 26366350 )
2015
13
FDG PET/CT images demonstrating Fournier gangrene with bilateral pelvic muscle extension in a patient with recurrent rectosigmoid cancer. ( 23510891 )
2014
14
Unusual site of metastasis detected with FDG PET/CT in a case of recurrent rectosigmoid cancer. ( 24300344 )
2014
15
Hartmann's procedure vs loop colostomy in the treatment of obstructive rectosigmoid cancer. ( 25324896 )
2014
16
Pylephlebitis in patient with covered perforated rectosigmoid cancer. ( 25340866 )
2014
17
A first report of tumor cell implantation after EMR in a patient with rectosigmoid cancer. ( 21762905 )
2012
18
Surgical techniques of laparoscopic peritonectomy plus paraaortic lymph node dissection for the treatment of patients with positive lymph node metastasis and peritoneal seeding from rectosigmoid cancer. ( 22271336 )
2012
19
Palliative management for patients with subacute obstruction and stage IV unresectable rectosigmoid cancer: colostomy versus endoscopic stenting: final results of a prospective randomized trial. ( 22575396 )
2012
20
Complete Response of Isolated Para-aortic Lymph Node Recurrence from Rectosigmoid Cancer Treated by Chemoradiation Therapy with Capecitabine/Oxaliplatin plus Bevacizumab: A Case Report. ( 22679426 )
2012
21
Rectosigmoid xanthoma as a predictive marker for sporadic rectosigmoid cancer. ( 21633307 )
2011
22
Deep infiltrating cervical endometriosis mimicking rectosigmoid cancer. ( 21642825 )
2011
23
Recovery of upper gastrointestinal bowel movement after rectosigmoid cancer surgery: a pilot transit analysis. ( 22808607 )
2011
24
Peritoneal microdialysis. Early diagnosis of anastomotic leakage after low anterior resection for rectosigmoid cancer. ( 19919919 )
2009
25
Preoperative irradiation and surgery for local recurrence of rectal and rectosigmoid cancer. Prognostic factors with regard to survival and further local recurrence. ( 18028472 )
2008
26
Erratum: Systematic review on the short term outcome of laparoscopic resection for colon and rectosigmoid cancer. ( 18205846 )
2008
27
Feasibility of laparoscopic D3 lymphadenectomy for male rectosigmoid cancer with clinically positive lymph nodes. ( 18288527 )
2008
28
Risk of deep vein thrombosis following laparoscopic rectosigmoid cancer resection in chinese patients. ( 18490217 )
2008
29
The depth of tumor invasion beyond the outer border of the muscularis propria as a prognostic factor for T3 rectal/rectosigmoid cancer. ( 18630458 )
2008
30
Sexual function in men with rectal and rectosigmoid cancer after laparoscopic and open surgery. ( 18795677 )
2008
31
Laser Doppler assessment of the influence of division at the root of the inferior mesenteric artery on anastomotic blood flow in rectosigmoid cancer surgery. ( 17082922 )
2007
32
Short- and midterm outcomes of laparoscopic surgery compared for 131 patients with rectal and rectosigmoid cancer. ( 17285382 )
2007
33
Re: rectosigmoid cancer after radiotherapy for prostate cancer can be detected early and successfully treated. ( 17419874 )
2007
34
Laparoscopic prophylactic oophorectomy plus N3 lymphadenectomy for advanced rectosigmoid cancer. ( 17447107 )
2007
35
Economics and the laparoscopic surgery learning curve: comparison with open surgery for rectosigmoid cancer. ( 17623232 )
2007
36
Systematic review on the short-term outcome of laparoscopic resection for colon and rectosigmoid cancer. ( 16684081 )
2006
37
Rectosigmoid cancer after radiotherapy for prostate cancer can be detected early and successfully treated. ( 16732819 )
2006
38
Comparison of long-term outcome of laparoscopic and conventional surgery for advanced colon and rectosigmoid cancer. ( 16795970 )
2006
39
Radiologic assessment of rectosigmoid cancer before and after neoadjuvant radiation therapy: comparison between quantitation techniques. ( 15671374 )
2005
40
A case of rectosigmoid cancer metastasizing to a fistula in ano. ( 16275674 )
2005
41
Obstructive jaundice caused by lymphatic remetastasis from the hepatic metastasis of rectosigmoid cancer. ( 11702258 )
2001
42
Intraoperative radiation therapy for locally advanced recurrent rectal or rectosigmoid cancer. ( 11165686 )
2001
43
Use of self-expanding metal stents for palliation of rectosigmoid cancer. ( 11174293 )
2001
44
Blood dissemination of colonic epithelial cells during no-touch surgery for rectosigmoid cancer. ( 10437871 )
1999
45
The impact of 5-fluorouracil and intraoperative electron beam radiation therapy on the outcome of patients with locally advanced primary rectal and rectosigmoid cancer. ( 9712564 )
1998
46
Application of rectal stents for palliation of obstructing rectosigmoid cancer. ( 9214327 )
1997
47
Radiotherapy treatment for isolated loco-regional recurrence of rectosigmoid cancer following definitive surgery: Peter MacCallum Cancer Institute experience, 1981-1990. ( 9276368 )
1997
48
Intraoperative radiation therapy for locally advanced recurrent rectal or rectosigmoid cancer. ( 7564378 )
1995
49
Nerve-sparing surgery in 302 resectable rectosigmoid cancer patients: genitourinary morbidity and 10-year survival. ( 8313791 )
1994
50
Radiation enhancement of laser palliation for advanced rectal and rectosigmoid cancer: a pilot study. ( 7688336 )
1993

Variations for Rectosigmoid Cancer

Expression for Rectosigmoid Cancer

Search GEO for disease gene expression data for Rectosigmoid Cancer.

Pathways for Rectosigmoid Cancer

Pathways related to Rectosigmoid Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 CTNNB1 FASLG HRAS IL10 IL6 KRAS
2
Show member pathways
12.99 CTNNB1 FASLG HRAS IL6 KRAS MAPK1
3
Show member pathways
12.97 CTNNB1 FASLG HRAS IL6 KRAS MAPK1
4
Show member pathways
12.97 CTNNB1 FASLG HRAS IL6 KRAS MAPK1
5
Show member pathways
12.92 HRAS KRAS MAPK1 MLH1 MSH2 MSH6
6
Show member pathways
12.88 CTSL FASLG HRAS IL10 IL6 MAPK1
7
Show member pathways
12.82 CTSL FASLG HRAS KRAS MAPK1
8
Show member pathways
12.8 CTNNB1 HRAS KRAS MAPK1 MLH1 MSH2
9
Show member pathways
12.77 CTNNB1 HRAS KRAS MAPK1 MLH1
10
Show member pathways
12.74 CTNNB1 FASLG HRAS KRAS MAPK1
11
Show member pathways
12.72 CTNNB1 FASLG HRAS KRAS MAPK1
12
Show member pathways
12.71 HRAS IL6 KRAS MAPK1 MSH6
13
Show member pathways
12.51 HRAS IL10 IL6 KRAS MAPK1
14
Show member pathways
12.43 HRAS IL10 KRAS MAPK1
15
Show member pathways
12.43 CTNNB1 HRAS KRAS MAPK1
16
Show member pathways
12.41 CTNNB1 HRAS KRAS MAPK1
17
Show member pathways
12.41 CTNNB1 HRAS IL6 KRAS MAPK1
18
Show member pathways
12.4 HRAS IL10 IL6 KRAS MAPK1
19
Show member pathways
12.4 CTNNB1 HRAS IL10 IL6 KRAS MAPK1
20 12.37 CTNNB1 HRAS IL6 KRAS
21 12.33 CTNNB1 FASLG HRAS IL6 KRAS MAPK1
22
Show member pathways
12.24 CTNNB1 HRAS KRAS MAPK1 MMP7
23 12.18 HRAS IL6 KRAS MAPK1
24 12.18 CTNNB1 CTSL FASLG HRAS KRAS MAPK1
25
Show member pathways
12.16 HRAS IL10 IL6 KRAS MAPK1
26
Show member pathways
12.12 CTNNB1 HRAS IL6 MAPK1
27
Show member pathways
12.09 HRAS IL10 IL6 KRAS MAPK1
28 12.09 CTNNB1 HRAS KRAS MAPK1
29 12.08 CTNNB1 KRAS MAPK1 MSH2 MSH6
30 12.05 CTSL HRAS KRAS MAPK1
31
Show member pathways
12.02 CTNNB1 HRAS IL6 MAPK1
32 12.01 CTNNB1 HRAS KRAS MAPK1
33 11.96 CEACAM5 ENG IL10 IL6
34 11.96 CTNNB1 HRAS KRAS MAPK1
35 11.93 CTNNB1 HRAS KRAS MAPK1
36 11.92 CTNNB1 FASLG HRAS KRAS MAPK1
37 11.9 ENG KRAS MAPK1
38
Show member pathways
11.88 CTNNB1 HRAS MAPK1
39 11.87 HRAS IL6 KRAS MAPK1
40 11.85 HRAS KRAS MAPK1
41
Show member pathways
11.85 MLH1 MSH2 MSH6 PMS2
42
Show member pathways
11.82 HRAS KRAS MAPK1
43 11.82 HRAS IL10 IL6 KRAS MAPK1
44 11.77 IL10 IL6 MAPK1
45
Show member pathways
11.77 FASLG HRAS IL10 IL6 KRAS MAPK1
46 11.76 HRAS KRAS MAPK1
47 11.69 HRAS KRAS MAPK1
48
Show member pathways
11.69 HRAS KRAS MAPK1
49 11.65 HRAS KRAS MAPK1
50 11.63 CTNNB1 ENG HRAS

GO Terms for Rectosigmoid Cancer

Cellular components related to Rectosigmoid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.16 MLH1 PMS2
2 MutSalpha complex GO:0032301 8.96 MSH2 MSH6
3 mismatch repair complex GO:0032300 8.92 MLH1 MSH2 MSH6 PMS2

Biological processes related to Rectosigmoid Cancer according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 CTNNB1 FASLG HRAS IL6 KRAS MAPK1
2 positive regulation of protein phosphorylation GO:0001934 9.83 ENG HRAS KRAS WDFY2
3 positive regulation of gene expression GO:0010628 9.8 CRP CTNNB1 ENG HRAS IL6 KRAS
4 response to glucocorticoid GO:0051384 9.77 IL10 IL6 KRAS
5 negative regulation of cell differentiation GO:0045596 9.75 CTNNB1 KRAS MAPK1
6 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.69 MLH1 MSH2 MSH6
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.62 MLH1 MSH2
8 negative regulation of lipid storage GO:0010888 9.61 CRP IL6
9 regulation of protein localization to cell surface GO:2000008 9.6 CTNNB1 RAB11B
10 positive regulation of helicase activity GO:0051096 9.58 MSH2 MSH6
11 response to isolation stress GO:0035900 9.56 HRAS KRAS
12 trachea formation GO:0060440 9.54 CTNNB1 MAPK1
13 isotype switching GO:0045190 9.5 MLH1 MSH2 MSH6
14 maintenance of DNA repeat elements GO:0043570 9.49 MSH2 MSH6
15 positive regulation of isotype switching to IgA isotypes GO:0048298 9.48 MLH1 MSH2
16 central nervous system vasculogenesis GO:0022009 9.46 CTNNB1 ENG
17 mismatch repair GO:0006298 9.46 MLH1 MSH2 MSH6 PMS2
18 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.37 MLH1 MSH2
19 pyrimidine dimer repair GO:0006290 9.27 MSH6
20 replication fork arrest GO:0043111 9.25 MSH6
21 meiotic mismatch repair GO:0000710 9.13 MSH6
22 somatic recombination of immunoglobulin gene segments GO:0016447 9.13 MLH1 MSH2 MSH6
23 somatic hypermutation of immunoglobulin genes GO:0016446 8.92 MLH1 MSH2 MSH6 PMS2
24 cellular response to DNA damage stimulus GO:0006974 10.01 MAPK1 MLH1 MSH2 MSH6 PMS2

Molecular functions related to Rectosigmoid Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase activity GO:0016887 9.78 MLH1 MSH2 MSH6 PMS2
2 GDP binding GO:0019003 9.54 HRAS KRAS RAB11B
3 MutLalpha complex binding GO:0032405 9.46 MSH2 MSH6
4 MutSalpha complex binding GO:0032407 9.43 MLH1 PMS2
5 oxidized purine DNA binding GO:0032357 9.4 MSH2 MSH6
6 single thymine insertion binding GO:0032143 9.32 MSH2 MSH6
7 single guanine insertion binding GO:0032142 9.16 MSH2 MSH6
8 guanine/thymine mispair binding GO:0032137 9.13 MLH1 MSH2 MSH6
9 mismatched DNA binding GO:0030983 8.92 MLH1 MSH2 MSH6 PMS2
10 protein binding GO:0005515 10.19 CRP CTNNB1 CTSL ENG FASLG HRAS

Sources for Rectosigmoid Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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