Rectosigmoid Junction Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Rectosigmoid Junction Neoplasm

MalaCards integrated aliases for Rectosigmoid Junction Neoplasm:

Name: Rectosigmoid Junction Neoplasm ¹² ¹⁵

Neoplasm of Rectosigmoid Junction ¹² ⁷¹

Rectosigmoid Neoplasm ¹² ⁷⁴

Malignant Tumor of Rectosigmoid Junction ⁷¹

Carcinoma of the Rectosigmoid Junction ⁷¹

Rectosigmoid Carcinoma ⁷¹

Rectosigmoid Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Cardiovascular diseases Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2780

NCIt ⁵⁰ C4877

SNOMED-CT ⁶⁷ 126848003

UMLS ⁷¹ C0153443 C0345873 C0559004 more

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Summaries for Rectosigmoid Junction Neoplasm

MalaCards based summary : Rectosigmoid Junction Neoplasm, also known as neoplasm of rectosigmoid junction, is related to rectosigmoid cancer and thymus adenocarcinoma. An important gene associated with Rectosigmoid Junction Neoplasm is ZNF750 (Zinc Finger Protein 750). The drugs Capecitabine and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon.

Wikipedia : ⁷⁴ Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development... more...

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Related Diseases for Rectosigmoid Junction Neoplasm

Diseases related to Rectosigmoid Junction Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 237)

#	Related Disease	Score	Top Affiliating Genes
1	rectosigmoid cancer	32.4	KRAS CEACAM5
2	thymus adenocarcinoma	10.1	KRT20 CEACAM5
3	thyroid angiosarcoma	10.1	KRT20 CEACAM5
4	signet ring basal cell carcinoma	10.1	KRAS CEACAM5
5	immature teratoma of ovary	10.1	KRAS CEACAM5
6	pancreatic cystadenocarcinoma	10.1	KRAS CEACAM5
7	urachal adenocarcinoma	10.1	KRAS CEACAM5
8	descending colon cancer	10.1	KRAS CEACAM5
9	bile duct adenoma	10.1	KRT7 KRT20
10	bladder benign neoplasm	10.1	KRT7 KRT20
11	bile acid synthesis defect, congenital, 5	10.1	KRAS CEACAM5
12	nephrogenic adenoma of urinary bladder	10.1	KRT7 KRT20
13	atrophic vulva	10.1	KRT7 KRT20
14	small cell carcinoma of the bladder	10.1	KRT7 KRT20
15	cystitis cystica	10.1	KRT7 KRT20
16	ascending colon cancer	10.1	KRAS CEACAM5
17	urinary bladder small cell neuroendocrine carcinoma	10.1	KRT7 KRT20
18	jejunal neoplasm	10.1	KRT7 KRT20
19	jejunal cancer	10.1	KRT7 KRT20
20	jejunal adenocarcinoma	10.1	KRT7 KRT20
21	malignant exocrine pancreas neoplasm	10.1	KRAS CEACAM5
22	intratubular embryonal carcinoma	10.1	KRT7 KRT20
23	ovarian large-cell neuroendocrine carcinoma	10.1	KRT7 KRT20
24	papillary transitional carcinoma	10.1	KRT7 KRT20
25	supine hypotensive syndrome	10.1	KRT7 KRT20
26	ovarian cystadenoma	10.1	KRT7 CEACAM5
27	mucinous bronchioloalveolar adenocarcinoma	10.1	KRT7 KRT20
28	syringoma	10.1	KRT7 CEACAM5
29	meibomian cyst	10.1	KRT7 KRT20
30	acute orbital inflammation	10.1	KRT7 KRT20
31	glandular cystitis	10.1	KRT7 KRT20
32	nephrogenic adenoma of the urethra	10.1	KRT7 KRT20
33	leukoplakia of penis	10.0	KRT7 CEACAM5
34	vaginal adenoma	10.0	KRT7 KRT20
35	ovarian brenner tumor	10.0	KRT7 KRT20
36	vaginal benign neoplasm	10.0	KRT7 KRT20
37	ureter adenocarcinoma	10.0	KRT7 CEACAM5
38	bladder clear cell adenocarcinoma	10.0	KRT7 KRT20
39	mucinous adenofibroma	10.0	KRT7 CEACAM5
40	clear cell adenocarcinoma	10.0	KRT7 KRT20
41	pancreatic foamy gland adenocarcinoma	10.0	KRT7 CEACAM5
42	prostate neuroendocrine neoplasm	10.0	KRT7 KRT20
43	malignant acrospiroma	10.0	KRT7 CEACAM5
44	bladder lateral wall cancer	10.0	KRT7 KRT20
45	anal paget's disease	10.0	KRT7 CEACAM5
46	cutaneous mucoepidermoid carcinoma	10.0	KRT7 CEACAM5
47	external ear carcinoma	10.0	KRT7 CEACAM5
48	vulval paget's disease	10.0	KRT7 CEACAM5
49	breast osteosarcoma	10.0	KRT7 KRT20
50	nodular hidradenoma	10.0	KRT7 CEACAM5

Comorbidity relations with Rectosigmoid Junction Neoplasm via Phenotypic Disease Network (PDN): (show all 15)

Active Peptic Ulcer Disease	Acute Cystitis
Ascending Colon Cancer	Cecal Benign Neoplasm
Colorectal Cancer	Deficiency Anemia
Descending Colon Cancer	Hepatic Flexure Cancer
Hydronephrosis	Intestinal Obstruction
Intestinal Perforation	Iron Deficiency Anemia
Paralytic Ileus	Protein-Energy Malnutrition
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Rectosigmoid Junction Neoplasm:

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Symptoms & Phenotypes for Rectosigmoid Junction Neoplasm

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Drugs & Therapeutics for Rectosigmoid Junction Neoplasm

Drugs for Rectosigmoid Junction Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Capecitabine

Approved, Investigational

Phase 4

154361-50-9

60953

Synonyms:

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

154361-50-9

158798-73-3

5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine

5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

AC1L1U83

AC1Q4KU8

Ambap154361-50-9

C110904

C12650

C15H22FN3O6

CAPE

Capecitabin

capecitabina

Capecitabina

capecitabine

Capecitabine

CAPECITABINE

Capécitabine

Capecitabine (JAN/USAN/INN)

Capecitabine [USAN]

capecitabinum

Capecitabinum

Capecitibine

Capiibine

Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester

Caxeta

CHEBI:31348

CHEMBL1773

CID60953

D01223

DB01101

FT-0082472

HSDB 7656

LS-59070

MolPort-005-938-254

N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate

R340

R-340

RG-340

Ro 09-1978

Ro 09-1978/000

Ro-09-1978

Ro-09-1978/000

S1156_Selleck

UNII-6804DJ8Z9U

Xabine

Xeloda

Xeloda (TN)

Xeloda, Captabin, Capecitabine

ZINC03806413

2

Cola

Phase 4

3

Antimetabolites

Phase 4

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	An Open Label, Phase II Study of Capecitabine (Xeloda) Plus Conformal Radiotherapy for Patients With Locally Advanced, Non-Metastatic Rectosigmoid Carcinoma	Terminated	NCT00216424	Phase 4	Capecitabine (Xeloda)
2	Evaluation of the Role of Low Inferior Mesenteric Artery Ligation During Laparoscopic Surgery for Rectosigmoid Tumors	Completed	NCT03557528

Search NIH Clinical Center for Rectosigmoid Junction Neoplasm

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Genetic Tests for Rectosigmoid Junction Neoplasm

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Anatomical Context for Rectosigmoid Junction Neoplasm

MalaCards organs/tissues related to Rectosigmoid Junction Neoplasm:

⁴⁰

Colon

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Publications for Rectosigmoid Junction Neoplasm

Articles related to Rectosigmoid Junction Neoplasm:

#	Title	Authors	PMID	Year
1	Subjects older than 60 years with negative findings on sigmoidoscopy should still undergo colonoscopy. ⁶¹	Yoshinaga M...Ikeda K	12063966	2002
2	Malignant colorectal obstruction: treatment with a flexible covered stent. ⁶¹	Choo IW...Kim SK	9457194	1998
3	[Ileal obstruction following radiosurgical treatment for rectosigmoid neoplasm]. ⁶¹	Cerrotta A...Zucali R	7617904	1995

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Genes for Rectosigmoid Junction Neoplasm

Genes related to Rectosigmoid Junction Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ZNF750	Zinc Finger Protein 750	Protein Coding	5.68	DISEASES inferred ¹⁵
2	GTF2H5	General Transcription Factor IIH Subunit 5	Protein Coding	5.57	DISEASES inferred ¹⁵
3	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	5.44	DISEASES inferred ¹⁵
4	KRT20	Keratin 20	Protein Coding	5.22	DISEASES inferred ¹⁵
5	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	5.11	DISEASES inferred ¹⁵
6	KRT7	Keratin 7	Protein Coding	4.94	DISEASES inferred ¹⁵
7	TANC1	Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1	Protein Coding	4.92	DISEASES inferred ¹⁵
8	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	4.92	DISEASES inferred ¹⁵

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Variations for Rectosigmoid Junction Neoplasm

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Expression for Rectosigmoid Junction Neoplasm

Search GEO for disease gene expression data for Rectosigmoid Junction Neoplasm.

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Pathways for Rectosigmoid Junction Neoplasm

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GO Terms for Rectosigmoid Junction Neoplasm

Biological processes related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	visual learning	GO:0008542	8.62	TANC1 KRAS

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Sources for Rectosigmoid Junction Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

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¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

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⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia