Rectosigmoid Junction Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Rectosigmoid Junction Neoplasm

MalaCards integrated aliases for Rectosigmoid Junction Neoplasm:

Name: Rectosigmoid Junction Neoplasm ¹² ¹⁵

Neoplasm of Rectosigmoid Junction ¹² ⁷²

Rectosigmoid Neoplasm ¹² ⁷⁵

Malignant Tumor of Rectosigmoid Junction ⁷²

Carcinoma of the Rectosigmoid Junction ⁷²

Rectosigmoid Carcinoma ⁷²

Rectosigmoid Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2780

NCIt ⁵⁰ C4877

UMLS ⁷² C0153443 C0345873 C0559004 more

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Summaries for Rectosigmoid Junction Neoplasm

MalaCards based summary : Rectosigmoid Junction Neoplasm, also known as neoplasm of rectosigmoid junction, is related to large intestine cancer and rectosigmoid cancer. An important gene associated with Rectosigmoid Junction Neoplasm is SIL1 (SIL1 Nucleotide Exchange Factor), and among its related pathways/superpathways are Busulfan Pathway, Pharmacodynamics and Doxorubicin Pathway, Pharmacokinetics. The drugs Capecitabine and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon.

Wikipedia : ⁷⁵ Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from... more...

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Related Diseases for Rectosigmoid Junction Neoplasm

Diseases related to Rectosigmoid Junction Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)

#	Related Disease	Score	Top Affiliating Genes
1	large intestine cancer	28.0	SIL1 MSH2 MLH1 CEACAM6 CEACAM5 CD86
2	rectosigmoid cancer	12.0
3	appendix carcinoid tumor	10.4	MSH2 MLH1
4	colorectal cancer, hereditary nonpolyposis, type 7	10.4	MSH2 MLH1
5	adenosquamous colon carcinoma	10.4	MSH2 MLH1
6	lower lip cancer	10.4	MSH2 MLH1
7	sebaceous adenoma	10.4	MSH2 MLH1
8	anal fistula	10.4	MSH2 MLH1
9	melanocytic nevus syndrome, congenital	10.3	MSH2 MLH1
10	epididymis adenocarcinoma	10.3	CEACAM5 CD86
11	epididymis cancer	10.3	CEACAM5 CD86
12	gallbladder squamous cell carcinoma	10.3	CEACAM5 CD86
13	childhood kidney cell carcinoma	10.3	MSH2 MLH1
14	colorectal cancer, hereditary nonpolyposis, type 4	10.3	MSH2 MLH1
15	lymphohistiocytoid mesothelioma	10.3	CEACAM5 CD86
16	vulval paget's disease	10.3	CEACAM5 CD86
17	vulva adenocarcinoma	10.3	CEACAM5 CD86
18	cecum adenocarcinoma	10.3	MSH2 MLH1
19	cerebral primitive neuroectodermal tumor	10.3	MSH2 ENO2
20	lynch syndrome i	10.3	MSH2 MLH1
21	sebaceous adenocarcinoma	10.3	MSH2 MLH1
22	keratoacanthoma	10.2	MSH2 MLH1
23	descending colon cancer	10.2	MSH2 CEACAM5
24	muir-torre syndrome	10.2	MSH2 MLH1
25	small intestine cancer	10.2	MSH2 MLH1
26	melanotic medulloblastoma	10.2	ENO2 CEACAM5
27	atypical follicular adenoma	10.2	ENO2 CEACAM5
28	mismatch repair cancer syndrome	10.2	MSH2 MLH1
29	rete testis adenocarcinoma	10.2	ENO2 CEACAM5
30	gastric small cell carcinoma	10.2	ENO2 CEACAM5
31	colorectal cancer, hereditary nonpolyposis, type 5	10.2	MSH2 MLH1
32	mucinous ovarian cystadenoma	10.2	ENO2 CEACAM5
33	breast myoepithelial neoplasm	10.2	ENO2 CEACAM5
34	breast adenomyoepithelioma	10.2	ENO2 CEACAM5
35	familial colorectal cancer	10.2	MSH2 MLH1
36	rete testis neoplasm	10.2	ENO2 CEACAM5
37	chondroid chordoma	10.2	ENO2 CEACAM5
38	congenital epulis	10.1	ENO2 CEACAM5
39	mixed cell type cancer	10.1	ENO2 CEACAM5
40	mixed ductal-endocrine carcinoma	10.1	ENO2 CEACAM5
41	adenoma	10.1
42	tracheal cancer	10.1	ENO2 CEACAM5
43	alveolar soft part sarcoma	10.0	MLH1 ENO2
44	villous adenoma	10.0
45	colorectal adenoma	10.0	MSH2 MLH1
46	female reproductive system disease	10.0	MSH2 MLH1
47	skin benign neoplasm	10.0	MSH2 MLH1 ENO2
48	large cell carcinoma	10.0	ENO2 CEACAM5
49	intestinal benign neoplasm	9.9	MSH2 MLH1 CEACAM5
50	colonic disease	9.9	MSH2 MLH1 CEACAM5

Comorbidity relations with Rectosigmoid Junction Neoplasm via Phenotypic Disease Network (PDN): (show all 15)

Active Peptic Ulcer Disease	Acute Cystitis
Ascending Colon Cancer	Cecal Benign Neoplasm
Colorectal Cancer	Deficiency Anemia
Descending Colon Cancer	Hepatic Flexure Cancer
Hydronephrosis	Intestinal Obstruction
Intestinal Perforation	Iron Deficiency Anemia
Paralytic Ileus	Protein-Energy Malnutrition
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Rectosigmoid Junction Neoplasm:

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Symptoms & Phenotypes for Rectosigmoid Junction Neoplasm

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Drugs & Therapeutics for Rectosigmoid Junction Neoplasm

Drugs for Rectosigmoid Junction Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Capecitabine

Approved, Investigational

Phase 4

154361-50-9

60953

Synonyms:

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

154361-50-9

158798-73-3

5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine

5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

AC1L1U83

AC1Q4KU8

Ambap154361-50-9

C110904

C12650

C15H22FN3O6

CAPE

Capecitabin

capecitabina

Capecitabina

capecitabine

Capecitabine

CAPECITABINE

Capécitabine

Capecitabine (JAN/USAN/INN)

Capecitabine [USAN]

capecitabinum

Capecitabinum

Capecitibine

Capiibine

Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester

Caxeta

CHEBI:31348

CHEMBL1773

CID60953

D01223

DB01101

FT-0082472

HSDB 7656

LS-59070

MolPort-005-938-254

N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate

R340

R-340

RG-340

Ro 09-1978

Ro 09-1978/000

Ro-09-1978

Ro-09-1978/000

S1156_Selleck

UNII-6804DJ8Z9U

Xabine

Xeloda

Xeloda (TN)

Xeloda, Captabin, Capecitabine

ZINC03806413

2

Cola

Phase 4

3

Antimetabolites, Antineoplastic

Phase 4

4

Antimetabolites

Phase 4

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	An Open Label, Phase II Study of Capecitabine (Xeloda) Plus Conformal Radiotherapy for Patients With Locally Advanced, Non-Metastatic Rectosigmoid Carcinoma	Terminated	NCT00216424	Phase 4	Capecitabine (Xeloda)

Search NIH Clinical Center for Rectosigmoid Junction Neoplasm

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Genetic Tests for Rectosigmoid Junction Neoplasm

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Anatomical Context for Rectosigmoid Junction Neoplasm

MalaCards organs/tissues related to Rectosigmoid Junction Neoplasm:

⁴¹

Colon

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Publications for Rectosigmoid Junction Neoplasm

Articles related to Rectosigmoid Junction Neoplasm:

#	Title	Authors	PMID	Year
1	Subjects older than 60 years with negative findings on sigmoidoscopy should still undergo colonoscopy. ³⁸	Yoshinaga M...Ikeda K	12063966	2002
2	Malignant colorectal obstruction: treatment with a flexible covered stent. ³⁸	Choo IW...Kim SK	9457194	1998
3	[Ileal obstruction following radiosurgical treatment for rectosigmoid neoplasm]. ³⁸	Cerrotta A...Zucali R	7617904	1995

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Genes for Rectosigmoid Junction Neoplasm

Genes related to Rectosigmoid Junction Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SIL1	SIL1 Nucleotide Exchange Factor	Protein Coding	14.6	DISEASES inferred ¹⁵
2	CD86	CD86 Molecule	Protein Coding	13.96	DISEASES inferred ¹⁵
3	MSH2	MutS Homolog 2	Protein Coding	13.89	DISEASES inferred ¹⁵
4	MLH1	MutL Homolog 1	Protein Coding	13.74	DISEASES inferred ¹⁵
5	ENO2	Enolase 2	Protein Coding	13.69	DISEASES inferred ¹⁵
6	PPT1	Palmitoyl-Protein Thioesterase 1	Protein Coding	13.42	DISEASES inferred ¹⁵
7	CEACAM6	CEA Cell Adhesion Molecule 6	Protein Coding	5.17	DISEASES inferred ¹⁵
8	APOLD1	Apolipoprotein L Domain Containing 1	Protein Coding	4.28	DISEASES inferred ¹⁵
9	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	4.2	DISEASES inferred ¹⁵

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Variations for Rectosigmoid Junction Neoplasm

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Expression for Rectosigmoid Junction Neoplasm

Search GEO for disease gene expression data for Rectosigmoid Junction Neoplasm.

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Pathways for Rectosigmoid Junction Neoplasm

Pathways related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Busulfan Pathway, Pharmacodynamics ⁶¹ Show member pathways Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) ¹ FMO oxidises nucleophiles ⁶⁶	10.97	MSH2 MLH1
2	Doxorubicin Pathway, Pharmacokinetics ⁶¹ Show member pathways Doxorubicin Pathway (Cancer Cell), Pharmacodynamics ⁶¹	10.86	MSH2 MLH1
3	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	10.86	CEACAM6 CEACAM5 CD86
4	DNA damage_Role of Brca1 and Brca2 in DNA repair ²²	10.73	MSH2 MLH1 CD86
5	Platinum Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	10.62	MSH2 MLH1

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GO Terms for Rectosigmoid Junction Neoplasm

Cellular components related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mismatch repair complex	GO:0032300	8.62	MSH2 MLH1

Biological processes related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.48	MSH2 MLH1
2	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	GO:0007157	9.46	CEACAM6 CEACAM5
3	mismatch repair	GO:0006298	9.43	MSH2 MLH1
4	somatic hypermutation of immunoglobulin genes	GO:0016446	9.4	MSH2 MLH1
5	negative regulation of anoikis	GO:2000811	9.37	CEACAM6 CEACAM5
6	isotype switching	GO:0045190	9.32	MSH2 MLH1
7	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.26	MSH2 MLH1
8	positive regulation of isotype switching to IgA isotypes	GO:0048298	9.16	MSH2 MLH1
9	somatic recombination of immunoglobulin gene segments	GO:0016447	8.96	MSH2 MLH1
10	somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	8.62	MSH2 MLH1

Molecular functions related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mismatched DNA binding	GO:0030983	8.96	MSH2 MLH1
2	guanine/thymine mispair binding	GO:0032137	8.62	MSH2 MLH1

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Sources for Rectosigmoid Junction Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹⁶ DrugBank

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¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia