Rectosigmoid Junction Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Rectosigmoid Junction Neoplasm, also known as neoplasm of rectosigmoid junction, is related to rectosigmoid cancer and rectum cancer. An important gene associated with Rectosigmoid Junction Neoplasm is GTF2H5 (General Transcription Factor IIH Subunit 5). The drugs Capecitabine and Antimetabolites have been mentioned in the context of this disorder. Affiliated tissues include colon, lymph node and liver, and related phenotype is neoplasm.

Wikipedia: ⁷⁵ Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development... more...

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Related Diseases for Rectosigmoid Junction Neoplasm

Diseases related to Rectosigmoid Junction Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 340)

#	Related Disease	Score	Top Affiliating Genes
1	rectosigmoid cancer	32.2	MLH1 KRAS CEACAM5
2	rectum cancer	30.3	MLH1 KRT20 KRAS CEACAM5
3	anal fistula	29.9	KRT7 KRT20
4	intrahepatic cholangiocarcinoma	29.7	KRT7 KRAS CEACAM5
5	obstructive jaundice	29.7	KRT7 CEACAM5
6	colon adenocarcinoma	29.3	MLH1 KRT20 KRAS CEACAM5
7	intestinal obstruction	29.1	KRT7 KRT20 CEACAM5 CDX2
8	anus disease	29.1	KRT7 KRAS CEACAM5 CDX2
9	appendix adenocarcinoma	28.8	KRT7 KRT20 KRAS CEACAM5 CDX2
10	cholangiocarcinoma	28.8	KRT7 KRT20 KRAS CEACAM5 CDX2
11	adenocarcinoma	28.6	MLH1 KRT7 KRT20 KRAS CEACAM5 CDX2
12	rectal benign neoplasm	28.3	MLH1 KRT7 KRT20 KRAS CEACAM5 CDX2
13	mucinous adenocarcinoma	28.3	MLH1 KRT7 KRT20 KRAS CEACAM5 CDX2
14	colorectal adenocarcinoma	28.3	MLH1 KRT7 KRT20 KRAS CEACAM5 CDX2
15	colonic benign neoplasm	28.3	MLH1 KRT7 KRT20 KRAS CEACAM5 CDX2
16	colorectal cancer	10.6
17	eccrine papillary adenoma	10.2	KRT20 CEACAM5
18	signet ring basal cell carcinoma	10.2	KRAS CEACAM5
19	immature teratoma of ovary	10.2	KRAS CEACAM5
20	ovarian cystadenoma	10.2	KRT7 CEACAM5
21	pancreatic cystadenocarcinoma	10.2	KRAS CEACAM5
22	hepatic flexure cancer	10.2	KRAS CEACAM5
23	apocrine adenocarcinoma	10.2	KRT7 CEACAM5
24	pancreatic mucinous cystadenoma	10.2	KRAS CEACAM5
25	syringoma	10.2	KRT7 CEACAM5
26	leukoplakia of penis	10.2	KRT7 CEACAM5
27	aggressive digital papillary adenocarcinoma	10.2	KRT7 CEACAM5
28	cutaneous mucoepidermoid carcinoma	10.2	KRT7 CEACAM5
29	malignant epithelial mesothelioma	10.2	KRT7 CEACAM5
30	malignant spiradenoma	10.2	KRT7 CEACAM5
31	spiradenoma	10.2	KRT7 CEACAM5
32	adenosquamous bile duct carcinoma	10.2	KRT7 CEACAM5
33	ureter squamous cell carcinoma	10.2	KRT7 CEACAM5
34	apocrine adenoma	10.2	KRT7 CEACAM5
35	vulval paget's disease	10.2	KRT7 CEACAM5
36	renal pelvis adenocarcinoma	10.2	KRT7 CEACAM5
37	malignant biphasic mesothelioma	10.2	KRT7 CEACAM5
38	adenoid basal cell carcinoma	10.2	KRT7 CEACAM5
39	nodular hidradenoma	10.2	KRT7 CEACAM5
40	hidradenoma	10.2	KRT7 CEACAM5
41	malignant acrospiroma	10.2	KRT7 CEACAM5
42	eccrine adenocarcinoma	10.2	KRT7 CEACAM5
43	bile duct mucoepidermoid carcinoma	10.2	KRT7 CEACAM5
44	male urethral cancer	10.2	KRT7 KRT20
45	clear cell hidradenoma	10.1	KRT7 CEACAM5
46	pericardial mesothelioma	10.1	KRT7 CEACAM5
47	pancreatoblastoma	10.1	KRAS CEACAM5
48	squamous cell bile duct carcinoma	10.1	KRT7 CEACAM5
49	adenoid squamous cell carcinoma	10.1	KRT7 CEACAM5
50	pericardium cancer	10.1	KRT7 CEACAM5

Comorbidity relations with Rectosigmoid Junction Neoplasm via Phenotypic Disease Network (PDN): (show all 15)

Active Peptic Ulcer Disease	Acute Cystitis
Ascending Colon Cancer	Cecal Benign Neoplasm
Colorectal Cancer	Deficiency Anemia
Descending Colon Cancer	Hepatic Flexure Cancer
Hydronephrosis	Intestinal Obstruction
Intestinal Perforation	Iron Deficiency Anemia
Paralytic Ileus	Protein-Energy Malnutrition
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Rectosigmoid Junction Neoplasm:

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Symptoms & Phenotypes for Rectosigmoid Junction Neoplasm

MGI Mouse Phenotypes related to Rectosigmoid Junction Neoplasm:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.02	CDX2 CEACAM5 KRAS MLH1 SMUG1

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Drugs & Therapeutics for Rectosigmoid Junction Neoplasm

Drugs for Rectosigmoid Junction Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Capecitabine

Approved, Investigational

Phase 4

154361-50-9

60953

Synonyms:

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

Capecitabin

Capecitabina

CAPECITABINE

Capécitabine

Capecitabinum

N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine

PENTYL [1-(3,4-DIHYDROXY-5-METHYL-OXOLAN-2-YL)-5-FLUORO-2-OXO-PYRIMIDIN-4-YL]AMINOFORMATE

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

R340

RO-091978000

RO-09-1978000

RO-09-1978-000

Ro-09-1978-000|Ro-091978000|Xeloda®

Xeloda

2

Antimetabolites

Phase 4

3

Cola

Phase 4

4

Aflibercept

Approved

Phase 2

862111-32-8

124490314

5

Levoleucovorin

Approved, Experimental, Investigational

Phase 2

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Synonyms:

(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate

(6R)-Leucovorin

(6R,2'S)-Folinic acid

(6R,S)-5-Formyltetrahydrofolate

(6S)-5-Formyl-5,6,7,8-tetrahydrofolate

(6S)-5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID

(6S)-5-Formyltetrahydrofolate

(6S)-5-FORMYLTETRAHYDROFOLIC ACID

(6S)-Folinate

(6S)-FOLINIC ACID

(6S)-LEUCOVORIN

(S)-LEUCOVORIN

[6R]-5-formyl-5,6,7,8-tetrahydrofolate

10-Formyl-7,8-dihydrofolate

10-Formyl-7,8-dihydrofolic acid

5 Formyltetrahydrofolate

5 Formyltetrahydropteroylglutamate

5-Formlyl-5,6,7,8-tetrahydrofolate,calcium salt

5-Formyl-(6S)-tetrahydrofolic acid

5-Formyl-5,6,7,8-tetrahydrofolate

5-Formyl-5,6,7,8-tetrahydrofolic acid

5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid

5-Formyltetrahydrofolate

5-Formyltetrahydrofolic acid

5-Formyltetrahydropteroylglutamate

5-Formyltetrahydropteroylglutamic acid

5-formylTHF

6 S Leucovorin

6R-Leucovorin

6S Leucovorin

6S-Leucovorin

6-S-Leucovorin

Acid, folinic

Acide folinique

Acido folinico

ácido levofolínico

Calcium citrovorum factor

Calcium folinate

Calcium leucovorin

CF

Citrovorum factor

Dextrofolinic acid

Factor, citrovorum

Folinate

Folinate, calcium

Folinic acid

Folinic acid calcium salt

Folinic acid calcium salt USP27

Folinic acid SF

Folinic acid-SF

FUSILEV

KHAPZORY

Kunyrin

L(-)-5-Formyl-5,6,7,8-tetrahydrofolate

L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid

Leucal

Leucoverin

Leucovorin

Leucovorin calcium

Leucovorin folinic acid

Leucovorin, (D)-isomer

Leucovorin, (DL)-isomer

Leucovorin, (R)-isomer

Leucovorin, (S)-isomer

Leucovorin, calcium

Leucovorin, calcium (1:1) salt

Leucovorin, calcium (1:1) salt, (DL)-isomer

Leucovorin, calcium (1:1) salt, (S)-isomer

Leucovorin, calcium (1:1) salt, pentahydrate

Leucovorin, monopotassium salt, (S)-isomer

Leucovorin, monosodium salt

Leucovorin, monosodium salt, (S)-isomer

Leucovorinum

Leukovorin

Leukovorum

Levo leucovorin

LEVOFOLENE

Levofolinate

LEVOFOLINIC ACID

Levoleucovorin

Levo-leucovorin

L-Folinate

L-FOLINIC ACID

LFP-754

L-Leucovorin

L-N-[P-[[(2-amino-5-Formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-glutamic acid

Monosodium salt leucovorin

N(5)-Formyltetrahydrofolate

N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid

N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamate

N-[4-({[(6S)-2-AMINO-5-FORMYL-4-OXO-1,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID

N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid

N5-Formyl-5,6,7,8-tetrahydrofolate

N5-Formyl-5,6,7,8-tetrahydrofolic acid

N5-Formyltetrahydrofolate

N5-Formyltetrahydrofolic acid

N5-Formyl-THF

Pteroyl-D-glutamate

Rescuvolin

S Leucovorin

S-Leucovorin

Welcovorin

Wellcovorin

6

Fluorouracil

Approved

Phase 2

51-21-8

3385

7

Oxaliplatin

Approved, Investigational

Phase 2

61825-94-3

43805 11947679 6857599

8

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 2

59-30-3

6037

9

Vitamins

Phase 2

10

Folate

Phase 2

11

Vitamin B9

Phase 2

12

Trace Elements

Phase 2

13

Angiogenesis Inhibitors

Phase 2

14

Vitamin B Complex

Phase 2

15

Antidotes

Phase 2

16

Micronutrients

Phase 2

17

Protective Agents

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	An Open Label, Phase II Study of Capecitabine (Xeloda) Plus Conformal Radiotherapy for Patients With Locally Advanced, Non-Metastatic Rectosigmoid Carcinoma	Terminated	NCT00216424	Phase 4	Capecitabine (Xeloda)
2	A Randomized Trial of the Altering Intake, Managing Symptoms Intervention for Bowel Dysfunction in Rectal Cancer Survivors Compared to a Healthy Living Education Control: A Feasibility and Preliminary Efficacy Study (AIMS-RC)	Active, not recruiting	NCT04205955	Phase 2
3	mFOLFOX6 vs. mFOLFOX6 + Aflibercept as Neoadjuvant Treatment in MRI-defined T3-rectal Cancer: a Randomized Phase-II-trial	Active, not recruiting	NCT03043729	Phase 2	Oxaliplatin;5-FU;Leucovorin
4	Role of CD133 and Microsatellite Status in Evaluation of Young Adults With Rectosigmoid Cancer Received Neoadjuvant Treatment	Unknown status	NCT03002727
5	A Study to Validate the Safety and Feasibility of ArtiSential in Colorectal Cancer Surgery Using Prospectively Constructed Multi-center Registry	Recruiting	NCT05566249
6	Circulating Tumor Elements in Patients With Rectal Cancer	Recruiting	NCT02874885
7	Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials	Recruiting	NCT05108298	Early Phase 1
8	Comparison of Rectosigmoid Resection and Seromuscular Tumor Shaving Methods in Ovarian Cancer Surgery (BROSEOC)	Recruiting	NCT04665635
9	Pilot Study of a Personalized Dietary Intervention to Manage Bowel Dysfunction in Rectal Cancer Survivors	Active, not recruiting	NCT03063918
10	A Randomized, Controlled, Parallel, Multicenter Study Assessing Perfusion Outcomes With PINPOINT® Near Infrared Fluorescence Imaging in Low Anterior Resection	Terminated	NCT02205307

Search NIH Clinical Center for Rectosigmoid Junction Neoplasm

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Genetic Tests for Rectosigmoid Junction Neoplasm

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Anatomical Context for Rectosigmoid Junction Neoplasm

Organs/tissues related to Rectosigmoid Junction Neoplasm:

MalaCards : Colon, Lymph Node, Liver, Prostate, Small Intestine, Kidney, Uterus

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Publications for Rectosigmoid Junction Neoplasm

Articles related to Rectosigmoid Junction Neoplasm:

(show top 50) (show all 346)

#	Title	Authors	PMID	Year
1	Robotic resection for obstructed rectosigmoid colon cancer with clinically suspicious para-aortic lymph node metastasis and direct invasion into the uterus - A video vignette. ⁶²	Bae SU...Baek SK	35596924	2022
2	D3 lymph node dissection with versus without left colic artery preservation in single-incision laparoscopic surgery for sigmoid and rectosigmoid cancer: A propensity score-matched analysis. ⁶²	Hiranuma C...Douden K	36443942	2022
3	Endoscopy Reports for Rectosigmoid Tumors: Frequently Missing Key Information Needed for Surgical Planning. ⁶²	Wlodarczyk J...Cologne KG	35659707	2022
4	Mechanical bowel preparation with or without oral antibiotics for rectal resection for cancer (REPCA trial): a study protocol for a multicenter randomized controlled trial. ⁶²	Olkina A...Petrov A	36151343	2022
5	Colorectal Cancer Risk Is Impacted by Sex and Type of Surgery After Bariatric Surgery. ⁶²	Hussan H...Lieberman D	35731459	2022
6	Rectosigmoid Cancer-Rectal Cancer or Sigmoid Cancer? ⁶²	Hui C...Pollom E	35848736	2022
7	Gastric Volvulus: Diagnosis and Successful Endoscopic De-rotation Towards Conservative Management in a Patient With Multiple Comorbidities. ⁶²	Zafar M...Ofuafor K	35854951	2022
8	Modification of ALPPS to avoid ischemia and congestion after stage 1: a case report. ⁶²	Ishihara M...Tanaka K	35867313	2022
9	Laparoscopic anterior resection for patients with rectosigmoid cancer in situs inversus totalis - a video vignette. ⁶²	Arita T...Otsuji E	35068038	2022
10	Robotic versus laparoscopic anterior resections for rectal and rectosigmoid cancer: an institutional experience. ⁶²	Donlon NE...O'Riordain DS	33846946	2022
11	Distance of Peritoneum to Inferior Mesenteric Artery Predicts the Operation Time During Laparoscopic Colectomy for Sigmoid or Rectosigmoid Colon Cancer. ⁶²	Saeki T...Kuroda D	35399172	2022
12	Efficacy of side-to-end anastomosis to prevent anastomotic leakage after anterior resection for rectal cancer. ⁶²	Kato H...Itano O	35003742	2022
13	National trends in hospitalizations among patients with colorectal cancer in the United States. ⁶²	Grewal US...Mills GM	35261440	2022
14	Risk factors and economic burden of postoperative anastomotic leakage related events in patients who underwent surgeries for colorectal cancer. ⁶²	Kang J...Lee KY	35584082	2022
15	Laparoscopic surgery using 8 K ultra-high-definition technology: Outcomes of a phase II study. ⁶²	Tsukamoto S...Kanemitsu Y	33881224	2022
16	A six years' experience with 41 cases of enterovesical fistula in a Tertiary National Hospital in Indonesia: A retrospective study. ⁶²	Widia F...Syaiful RA	35028134	2022
17	[The Validity of a Stent-Independent Strategy for Left-Sided Stenotic Colon Cancer]. ⁶²	Kubota S...Hakamada K	35046303	2021
18	ANALGESIC EFFECT OF VARIOUS RADIOPHARMACEUTICALS IN THE COMPLEX TREATMENT OF METASTATIC BONE DISEASE. ⁶²	Solodyannikova OI...Sukach GG	34965574	2021
19	A new spray-type adhesion barrier (AdSpray) improves condition for surgical treatment in the reversal of Hartmann procedure: A case report. ⁶²	Osumi W...Uchiyama K	35049209	2021
20	[A Case of Laparoscopic Resection for Rectal Cancer with Persistent Descending Mesocolon]. ⁶²	Matsumoto T...Otsuji E	35045499	2021
21	Correlation between ASA Grade with reversal of Hartmann's procedure - a retrospective study. ⁶²	Farah M...Ng P	35126744	2021
22	Necrotizing fasciitis of the lower extremity secondary to a perforated rectosigmoid tumor. ⁶²	Celik SU...Senocak R	34975101	2021
23	Rising incidence of colorectal cancer in individuals younger than 50 years and increasing mortality from rectosigmoid cancer in England. ⁶²	Ng OH...Arthur JD	34310037	2021
24	Clinical effect and standardization of indocyanine green angiography in the laparoscopic colorectal surgery. ⁶²	Son GM...Baek KR	35600102	2021
25	Metachronous common iliac lymph node metastasis after rectosigmoid colon cancer resection: A case report. ⁶²	Naoi D...Sata N	34280878	2021
26	Single-incision versus conventional multiport laparoscopic surgery for colorectal cancer: a meta-analysis of randomized controlled trials and propensity-score matched studies. ⁶²	Gu C...Wang Z	33829313	2021
27	Changes in colorectal cancer incidence by site and age from 1973 to 2015: a SEER database analysis. ⁶²	Yang L...Xia L	33025301	2021
28	Long-term outcome of indwelling colon observed seven years after radical resection for rectosigmoid cancer: A case report. ⁶²	Zhuang ZX...Wang ZQ	34307575	2021
29	Short-term clinical and oncological outcomes after single-incision plus one-port laparoscopic surgery for rectosigmoid cancer: a retrospective clinical analysis of 30 cases. ⁶²	Wu ZJ...Zheng FW	34250822	2021
30	Robotic low anterior resection with total hysterectomy, bilateral salpingo-oophorectomy and en bloc pelvic peritonectomy followed by hyperthermic intraperitoneal chemotherapy for the multi-modal treatment of rectosigmoid cancer with peritoneal seeding - A video vignette. ⁶²	Chen TC...Liang JT	33675572	2021
31	Implantation of rectosigmoid cancer in a preexisting anal fissure. ⁶²	Sato H...Uyama I	33786288	2021
32	Comprehensive analysis of lncRNA-associated ceRNA network reveals the novel potential of lncRNA, miRNA and mRNA biomarkers in human rectosigmoid junction cancer. ⁶²	Zhang Q...Ren S	33552263	2021
33	Safe Completion of Laparoscopic Anterior Resection in a Patient With a Solitary Pelvic Kidney: A Case Report. ⁶²	Park BK...Kim BG	33730797	2021
34	Pelvic local recurrence as first relapse predicts prognosis for clinical stage II/III lower rectal cancer: A clinicopathological investigation. ⁶²	Uda S...Makuuchi H	33414914	2021
35	Does the Endoscopic Surgical Skill Qualification System improve patients' outcome following laparoscopic surgery for colon cancer? A multicentre, retrospective analysis with propensity score matching. ⁶²	Kazama K...Rino Y	33608034	2021
36	Competing Endogenous RNA in Colorectal Cancer: An Analysis for Colon, Rectum, and Rectosigmoid Junction. ⁶²	Vieira LM...Walter MEMT	34178670	2021
37	RNA-Associated Co-expression Network Identifies Novel Biomarkers for Digestive System Cancer. ⁶²	Chen Z...Zhang L	33841514	2021
38	A Postsurgical Prognostic Nomogram for Locally Advanced Rectosigmoid Cancer to Assist in Patient Selection for Adjuvant Chemotherapy. ⁶²	Zhang C...Wang X	35004292	2021
39	Is early anvil placement an alternative technique to reduce anastomotic leak after rectosigmoid cancer resection? ⁶²	Ferahman S...Karabulut M	33576338	2021
40	Laparoscopic Surgery for Colorectal Cancer in Super-Elderly Patients: A Single-Center Analysis. ⁶²	Hashida H...Kaihara S	33234850	2020
41	Germline HOXB13 G84E mutation carriers and risk to twenty common types of cancer: results from the UK Biobank. ⁶²	Wei J...Xu J	32830201	2020
42	Three-trocar tubeless natural orifice specimen extraction surgery in rectosigmoid cancer - a video vignette. ⁶²	Luo Y...Huang M	32336013	2020
43	Laparoscopic vs. Open Surgery for Stage II/III Colon Cancer Patients With Body Mass Index >25 kg/m2. ⁶²	Kazama K...Rino Y	32606186	2020
44	Colorectal Intussusception Due to Rectosigmoid Junction Cancer: A Unique Surgical Challenge? ⁶²	Lianos GD...Lekkas E	31713812	2020
45	Robotic multivisceral resection for a locally advanced rectosigmoid cancer - a video vignette. ⁶²	Mykoniatis I...Khan J	31965699	2020
46	The effect of primary tumor radiotherapy in patients with Unresectable stage IV Rectal or Rectosigmoid Cancer: a propensity score matching analysis for survival. ⁶²	Wang G...Li L	32460810	2020
47	Patterns of Care for Stage II-III Rectosigmoid Cancers in the United States, 2004-2015. ⁶²	Sanford NN...Folkert MR	32235162	2020
48	Low rate of local recurrence detection by rectoscopy in follow-up of rectal cancer. ⁶²	Tronstad PK...Karliczek A	31556190	2020
49	Feasibility of needlescopic surgery for colorectal cancer: safety and learning curve for Japanese Endoscopic Surgical Skill Qualification System-unqualified young surgeons. ⁶²	Miki H...Ueno M	31087171	2020
50	Covid-19 mimicking symptoms in emergency gastrointestinal surgery cases during pandemic: A case series. ⁶²	Handaya AY...Fauzi AR	33137666	2020

Sources

Genes for Rectosigmoid Junction Neoplasm

Genes related to Rectosigmoid Junction Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GTF2H5	General Transcription Factor IIH Subunit 5	Protein Coding	5.01	DISEASES inferred ¹⁴
2	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	4.96	DISEASES inferred ¹⁴
3	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	4.78	DISEASES inferred ¹⁴
4	ZNF750	Zinc Finger Protein 750	Protein Coding	4.77	DISEASES inferred ¹⁴
5	KRT20	Keratin 20	Protein Coding	4.62	DISEASES inferred ¹⁴
6	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	4.46	DISEASES inferred ¹⁴
7	DHX32	DEAH-Box Helicase 32 (Putative)	Protein Coding	4.35	DISEASES inferred ¹⁴
8	MLH1	MutL Homolog 1	Protein Coding	4.35	DISEASES inferred ¹⁴
9	CDX2	Caudal Type Homeobox 2	Protein Coding	4.33	DISEASES inferred ¹⁴
10	KRT7	Keratin 7	Protein Coding	4.29	DISEASES inferred ¹⁴

Sources

Variations for Rectosigmoid Junction Neoplasm

Cosmic variations for Rectosigmoid Junction Neoplasm:

⁸ (show all 44)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM112254813	TP53	large intestine,rectum,other,ulcerative colitis	c.991C>T	p.Q331*	17:7673537-7673537	4
2	COSM144087932	TP53	large intestine,rectum,other,ulcerative colitis	c.514C>T	p.Q172*	17:7673537-7673537	4
3	COSM144014702	TP53	large intestine,rectum,other,ulcerative colitis	c.958C>T	p.Q320*	17:7673537-7673537	4
4	COSM122735329	TP53	large intestine,rectum,other,ulcerative colitis	c.595C>T	p.Q199*	17:7673537-7673537	4
5	COSM142561421	TP53	large intestine,rectum,other,ulcerative colitis	c.874C>T	p.Q292*	17:7673537-7673537	4
6	COSM143372079	TP53	large intestine,rectum,other,ulcerative colitis	c.874C>T	p.Q292*	17:7673537-7673537	4
7	COSM144311322	TP53	large intestine,rectum,other,ulcerative colitis	c.874C>T	p.Q292*	17:7673537-7673537	4
8	COSM87899785	TP53	large intestine,rectum,other,ulcerative colitis	c.991C>T	p.Q331*	17:7673537-7673537	4
9	COSM122272916	TP53	large intestine,rectum,other,ulcerative colitis	c.595C>T	p.Q199*	17:7673537-7673537	4
10	COSM143945088	TP53	large intestine,rectum,other,ulcerative colitis	c.514C>T	p.Q172*	17:7673537-7673537	4
11	COSM143158051	TP53	large intestine,rectum,other,ulcerative colitis	c.514C>T	p.Q172*	17:7673537-7673537	4
12	COSM93184982	TP53	large intestine,rectum,other,ulcerative colitis	c.991C>T	p.Q331*	17:7673537-7673537	4
13	COSM121877930	TP53	large intestine,rectum,other,ulcerative colitis	c.595C>T	p.Q199*	17:7673537-7673537	4
14	COSM105621819	TP53	large intestine,rectum,other,ulcerative colitis	c.782+644C>T	p.?	17:7673537-7673537	4
15	COSM144652581	TP53	large intestine,rectum,other,ulcerative colitis	c.874C>T	p.Q292*	17:7673537-7673537	4
16	COSM145019112	TP53	large intestine,rectum,other,ulcerative colitis	c.874C>T	p.Q292*	17:7673537-7673537	4
17	COSM111759749	TP53	large intestine,rectum,other,ulcerative colitis	c.991C>T	p.Q331*	17:7673537-7673537	4
18	COSM106054584	TP53	large intestine,rectum,other,ulcerative colitis	c.991C>T	p.Q331*	17:7673537-7673537	4
19	COSM142838247	TP53	large intestine,rectum,other,ulcerative colitis	c.991C>T	p.Q331*	17:7673537-7673537	4
20	COSM103099638	SMAD4	large intestine,rectum,other,ulcerative colitis	c.1546C>T	p.Q516*	18:51078354-51078354	4
21	COSM139783160	SMAD4	large intestine,rectum,other,ulcerative colitis	c.1258C>T	p.Q420*	18:51078354-51078354	4
22	COSM91397295	SMAD4	large intestine,rectum,other,ulcerative colitis	c.1546C>T	p.Q516*	18:51078354-51078354	4
23	COSM87804055	KRAS	large intestine,colon,other,ulcerative colitis	c.35G>T	p.G12V	12:25245350-25245350	4
24	COSM87804005	KRAS	large intestine,colon,other,ulcerative colitis	c.35G>A	p.G12D	12:25245350-25245350	4
25	COSM134990112	KRAS	large intestine,colon,other,ulcerative colitis	c.35G>A	p.G12D	12:25245350-25245350	4
26	COSM134990158	KRAS	large intestine,colon,other,ulcerative colitis	c.35G>T	p.G12V	12:25245350-25245350	4
27	COSM134990131	KRAS	large intestine,colon,other,ulcerative colitis	c.38G>A	p.G13D	12:25245347-25245347	4
28	COSM134615012	KRAS	large intestine,colon,other,ulcerative colitis	c.34G>T	p.G12C	12:25245351-25245351	4
29	COSM134614922	KRAS	large intestine,colon,other,ulcerative colitis	c.35G>A	p.G12D	12:25245350-25245350	4
30	COSM91859716	KRAS	large intestine,colon,other,ulcerative colitis	c.35G>A	p.G12D	12:25245350-25245350	4
31	COSM87811077	KRAS	large intestine,colon,other,ulcerative colitis	c.37G>A	p.G13S	12:25245348-25245348	4
32	COSM134990190	KRAS	large intestine,colon,other,ulcerative colitis	c.34G>T	p.G12C	12:25245351-25245351	4
33	COSM134614978	KRAS	large intestine,colon,other,ulcerative colitis	c.35G>T	p.G12V	12:25245350-25245350	4
34	COSM134995752	KRAS	large intestine,colon,other,ulcerative colitis	c.37G>A	p.G13S	12:25245348-25245348	4
35	COSM91859771	KRAS	large intestine,colon,other,ulcerative colitis	c.34G>T	p.G12C	12:25245351-25245351	4
36	COSM87804028	KRAS	large intestine,colon,other,ulcerative colitis	c.38G>A	p.G13D	12:25245347-25245347	4
37	COSM91865142	KRAS	large intestine,colon,other,ulcerative colitis	c.37G>A	p.G13S	12:25245348-25245348	4
38	COSM91859752	KRAS	large intestine,colon,other,ulcerative colitis	c.35G>T	p.G12V	12:25245350-25245350	4
39	COSM134614942	KRAS	large intestine,colon,other,ulcerative colitis	c.38G>A	p.G13D	12:25245347-25245347	4
40	COSM134622234	KRAS	large intestine,colon,other,ulcerative colitis	c.37G>A	p.G13S	12:25245348-25245348	4
41	COSM91859734	KRAS	large intestine,colon,other,ulcerative colitis	c.38G>A	p.G13D	12:25245347-25245347	4
42	COSM87804075	KRAS	large intestine,colon,other,ulcerative colitis	c.34G>T	p.G12C	12:25245351-25245351	4
43	COSM122380143	APC	large intestine,colon,other,Crohn disease	c.3386T>C	p.L1129S	5:112838980-112838980	3
44	COSM88864376	APC	large intestine,colon,other,Crohn disease	c.3386T>C	p.L1129S	5:112838980-112838980	3

Sources

Expression for Rectosigmoid Junction Neoplasm

Search GEO for disease gene expression data for Rectosigmoid Junction Neoplasm.

Sources

Pathways for Rectosigmoid Junction Neoplasm

Sources

GO Terms for Rectosigmoid Junction Neoplasm

Sources

Sources for Rectosigmoid Junction Neoplasm

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: RCT008 MIFTS: 42	Rectosigmoid Junction Neoplasm Categories: Cancer diseases, Cardiovascular diseases, Gastrointestinal diseases	Data Licensing For inquiries, contact: [email protected]
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