Rectosigmoid Junction Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Rectosigmoid Junction Neoplasm

MalaCards integrated aliases for Rectosigmoid Junction Neoplasm:

Name: Rectosigmoid Junction Neoplasm ¹² ¹⁵

Neoplasm of Rectosigmoid Junction ¹² ⁷¹

Rectosigmoid Neoplasm ¹² ⁷⁴

Malignant Tumor of Rectosigmoid Junction ⁷¹

Carcinoma of the Rectosigmoid Junction ⁷¹

Rectosigmoid Carcinoma ⁷¹

Rectosigmoid Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Cardiovascular diseases Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2780

NCIt ⁴⁹ C4877

UMLS ⁷¹ C0153443 C0345873 C0559004 more

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Summaries for Rectosigmoid Junction Neoplasm

MalaCards based summary : Rectosigmoid Junction Neoplasm, also known as neoplasm of rectosigmoid junction, is related to rectosigmoid cancer and villous adenoma. An important gene associated with Rectosigmoid Junction Neoplasm is APOLD1 (Apolipoprotein L Domain Containing 1), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Capecitabine and Antimetabolites have been mentioned in the context of this disorder. Affiliated tissues include colon.

Wikipedia : ⁷⁴ Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development... more...

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Related Diseases for Rectosigmoid Junction Neoplasm

Diseases related to Rectosigmoid Junction Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)

#	Related Disease	Score	Top Affiliating Genes
1	rectosigmoid cancer	33.1	CEACAM5 APOLD1
2	villous adenoma	30.0	CEACAM5 APOLD1
3	colon leiomyosarcoma	10.1	CEACAM5 APOLD1
4	rectum signet ring adenocarcinoma	10.1	CEACAM5 APOLD1
5	linitis plastica	10.1	CEACAM5 APOLD1
6	ascending colon cancer	10.1	CEACAM5 APOLD1
7	ovarian squamous cell carcinoma	10.1	CEACAM5 APOLD1
8	transverse colon cancer	10.1	CEACAM5 CDHR4
9	adenoma	10.1
10	large intestine lipoma	10.1	CEACAM5 APOLD1
11	colon sarcoma	10.1	CEACAM5 APOLD1
12	lipoma of colon	10.1	CEACAM5 APOLD1
13	hemorrhoid	10.0	CEACAM5 APOLD1
14	anus cancer	10.0	CEACAM5 APOLD1
15	rectum adenocarcinoma	10.0	CEACAM5 APOLD1
16	rectal disease	10.0	CEACAM5 APOLD1
17	large intestine cancer	9.9
18	myoblastoma	9.9	CEACAM6 CEACAM5
19	intestinal obstruction	9.9	CEACAM5 APOLD1
20	impotence	9.9
21	hypokalemia	9.9
22	intestinal benign neoplasm	9.9	CEACAM5 APOLD1
23	gastrointestinal system benign neoplasm	9.8	CEACAM5 APOLD1
24	gastrointestinal carcinoma	9.8	CEACAM6 CEACAM5
25	rectum cancer	9.6	CEACAM5 APOLD1
26	sigmoid neoplasm	8.3	TANC1 CSTB CEACAM6 CEACAM5 CDHR4 APOLD1

Comorbidity relations with Rectosigmoid Junction Neoplasm via Phenotypic Disease Network (PDN): (show all 15)

Active Peptic Ulcer Disease	Acute Cystitis
Ascending Colon Cancer	Cecal Benign Neoplasm
Colorectal Cancer	Deficiency Anemia
Descending Colon Cancer	Hepatic Flexure Cancer
Hydronephrosis	Intestinal Obstruction
Intestinal Perforation	Iron Deficiency Anemia
Paralytic Ileus	Protein-Energy Malnutrition
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Rectosigmoid Junction Neoplasm:

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Symptoms & Phenotypes for Rectosigmoid Junction Neoplasm

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Drugs & Therapeutics for Rectosigmoid Junction Neoplasm

Drugs for Rectosigmoid Junction Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Capecitabine

Approved, Investigational

Phase 4

154361-50-9

60953

Synonyms:

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

154361-50-9

158798-73-3

5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine

5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

AC1L1U83

AC1Q4KU8

Ambap154361-50-9

C110904

C12650

C15H22FN3O6

CAPE

Capecitabin

capecitabina

Capecitabina

capecitabine

Capecitabine

CAPECITABINE

Capécitabine

Capecitabine (JAN/USAN/INN)

Capecitabine [USAN]

capecitabinum

Capecitabinum

Capecitibine

Capiibine

Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester

Caxeta

CHEBI:31348

CHEMBL1773

CID60953

D01223

DB01101

FT-0082472

HSDB 7656

LS-59070

MolPort-005-938-254

N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate

R340

R-340

RG-340

Ro 09-1978

Ro 09-1978/000

Ro-09-1978

Ro-09-1978/000

S1156_Selleck

UNII-6804DJ8Z9U

Xabine

Xeloda

Xeloda (TN)

Xeloda, Captabin, Capecitabine

ZINC03806413

2

Antimetabolites

Phase 4

3

Cola

Phase 4

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	An Open Label, Phase II Study of Capecitabine (Xeloda) Plus Conformal Radiotherapy for Patients With Locally Advanced, Non-Metastatic Rectosigmoid Carcinoma	Terminated	NCT00216424	Phase 4	Capecitabine (Xeloda)

Search NIH Clinical Center for Rectosigmoid Junction Neoplasm

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Genetic Tests for Rectosigmoid Junction Neoplasm

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Anatomical Context for Rectosigmoid Junction Neoplasm

MalaCards organs/tissues related to Rectosigmoid Junction Neoplasm:

⁴⁰

Colon

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Publications for Rectosigmoid Junction Neoplasm

Articles related to Rectosigmoid Junction Neoplasm:

#	Title	Authors	PMID	Year
1	Subjects older than 60 years with negative findings on sigmoidoscopy should still undergo colonoscopy. ⁶¹	Yoshinaga M...Ikeda K	12063966	2002
2	Malignant colorectal obstruction: treatment with a flexible covered stent. ⁶¹	Choo IW...Kim SK	9457194	1998
3	[Ileal obstruction following radiosurgical treatment for rectosigmoid neoplasm]. ⁶¹	Cerrotta A...Zucali R	7617904	1995

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Genes for Rectosigmoid Junction Neoplasm

Genes related to Rectosigmoid Junction Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	APOLD1	Apolipoprotein L Domain Containing 1	Protein Coding	6.6	DISEASES inferred ¹⁵
2	CDHR4	Cadherin Related Family Member 4	Protein Coding	5.65	DISEASES inferred ¹⁵
3	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	5.3	DISEASES inferred ¹⁵
4	CSTB	Cystatin B	Protein Coding	5.1	DISEASES inferred ¹⁵
5	CEACAM6	CEA Cell Adhesion Molecule 6	Protein Coding	5.07	DISEASES inferred ¹⁵
6	TANC1	Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1	Protein Coding	5.03	DISEASES inferred ¹⁵
7	LCLAT1	Lysocardiolipin Acyltransferase 1	Protein Coding	4.88	DISEASES inferred ¹⁵

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Variations for Rectosigmoid Junction Neoplasm

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Expression for Rectosigmoid Junction Neoplasm

Search GEO for disease gene expression data for Rectosigmoid Junction Neoplasm.

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Pathways for Rectosigmoid Junction Neoplasm

Pathways related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	10.69	CEACAM6 CEACAM5

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GO Terms for Rectosigmoid Junction Neoplasm

Cellular components related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	anchored component of membrane	GO:0031225	8.62	CEACAM6 CEACAM5

Biological processes related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell adhesion	GO:0007155	9.43	CEACAM6 CEACAM5 CDHR4
2	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	GO:0007157	9.16	CEACAM6 CEACAM5
3	homophilic cell adhesion via plasma membrane adhesion molecules	GO:0007156	9.13	CEACAM6 CEACAM5 CDHR4
4	negative regulation of anoikis	GO:2000811	8.62	CEACAM6 CEACAM5

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Sources for Rectosigmoid Junction Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁹ Cosmic

¹⁰ dbSNP

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²⁰ GeneAnalytics

²¹ GeneCards

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²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

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⁴⁰ MalaCards

⁴¹ MedGen

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⁴⁷ NCBI Bookshelf

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⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

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⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

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⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia