MCID: RCT008
MIFTS: 27

Rectosigmoid Junction Neoplasm

Categories: Cancer diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Rectosigmoid Junction Neoplasm

MalaCards integrated aliases for Rectosigmoid Junction Neoplasm:

Name: Rectosigmoid Junction Neoplasm 12 15
Neoplasm of Rectosigmoid Junction 12 71
Rectosigmoid Neoplasm 12 74
Malignant Tumor of Rectosigmoid Junction 71
Carcinoma of the Rectosigmoid Junction 71
Rectosigmoid Carcinoma 71
Rectosigmoid Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2780
NCIt 50 C4877
SNOMED-CT 67 126848003
UMLS 71 C0153443 C0345873 C0559004 more

Summaries for Rectosigmoid Junction Neoplasm

MalaCards based summary : Rectosigmoid Junction Neoplasm, also known as neoplasm of rectosigmoid junction, is related to rectosigmoid cancer and thymus adenocarcinoma. An important gene associated with Rectosigmoid Junction Neoplasm is ZNF750 (Zinc Finger Protein 750). The drugs Capecitabine and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon.

Wikipedia : 74 Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development... more...

Related Diseases for Rectosigmoid Junction Neoplasm

Diseases related to Rectosigmoid Junction Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 237)
# Related Disease Score Top Affiliating Genes
1 rectosigmoid cancer 32.4 KRAS CEACAM5
2 thymus adenocarcinoma 10.1 KRT20 CEACAM5
3 thyroid angiosarcoma 10.1 KRT20 CEACAM5
4 signet ring basal cell carcinoma 10.1 KRAS CEACAM5
5 immature teratoma of ovary 10.1 KRAS CEACAM5
6 pancreatic cystadenocarcinoma 10.1 KRAS CEACAM5
7 urachal adenocarcinoma 10.1 KRAS CEACAM5
8 descending colon cancer 10.1 KRAS CEACAM5
9 bile duct adenoma 10.1 KRT7 KRT20
10 bladder benign neoplasm 10.1 KRT7 KRT20
11 bile acid synthesis defect, congenital, 5 10.1 KRAS CEACAM5
12 nephrogenic adenoma of urinary bladder 10.1 KRT7 KRT20
13 atrophic vulva 10.1 KRT7 KRT20
14 small cell carcinoma of the bladder 10.1 KRT7 KRT20
15 cystitis cystica 10.1 KRT7 KRT20
16 ascending colon cancer 10.1 KRAS CEACAM5
17 urinary bladder small cell neuroendocrine carcinoma 10.1 KRT7 KRT20
18 jejunal neoplasm 10.1 KRT7 KRT20
19 jejunal cancer 10.1 KRT7 KRT20
20 jejunal adenocarcinoma 10.1 KRT7 KRT20
21 malignant exocrine pancreas neoplasm 10.1 KRAS CEACAM5
22 intratubular embryonal carcinoma 10.1 KRT7 KRT20
23 ovarian large-cell neuroendocrine carcinoma 10.1 KRT7 KRT20
24 papillary transitional carcinoma 10.1 KRT7 KRT20
25 supine hypotensive syndrome 10.1 KRT7 KRT20
26 ovarian cystadenoma 10.1 KRT7 CEACAM5
27 mucinous bronchioloalveolar adenocarcinoma 10.1 KRT7 KRT20
28 syringoma 10.1 KRT7 CEACAM5
29 meibomian cyst 10.1 KRT7 KRT20
30 acute orbital inflammation 10.1 KRT7 KRT20
31 glandular cystitis 10.1 KRT7 KRT20
32 nephrogenic adenoma of the urethra 10.1 KRT7 KRT20
33 leukoplakia of penis 10.0 KRT7 CEACAM5
34 vaginal adenoma 10.0 KRT7 KRT20
35 ovarian brenner tumor 10.0 KRT7 KRT20
36 vaginal benign neoplasm 10.0 KRT7 KRT20
37 ureter adenocarcinoma 10.0 KRT7 CEACAM5
38 bladder clear cell adenocarcinoma 10.0 KRT7 KRT20
39 mucinous adenofibroma 10.0 KRT7 CEACAM5
40 clear cell adenocarcinoma 10.0 KRT7 KRT20
41 pancreatic foamy gland adenocarcinoma 10.0 KRT7 CEACAM5
42 prostate neuroendocrine neoplasm 10.0 KRT7 KRT20
43 malignant acrospiroma 10.0 KRT7 CEACAM5
44 bladder lateral wall cancer 10.0 KRT7 KRT20
45 anal paget's disease 10.0 KRT7 CEACAM5
46 cutaneous mucoepidermoid carcinoma 10.0 KRT7 CEACAM5
47 external ear carcinoma 10.0 KRT7 CEACAM5
48 vulval paget's disease 10.0 KRT7 CEACAM5
49 breast osteosarcoma 10.0 KRT7 KRT20
50 nodular hidradenoma 10.0 KRT7 CEACAM5

Comorbidity relations with Rectosigmoid Junction Neoplasm via Phenotypic Disease Network (PDN): (show all 15)


Active Peptic Ulcer Disease Acute Cystitis
Ascending Colon Cancer Cecal Benign Neoplasm
Colorectal Cancer Deficiency Anemia
Descending Colon Cancer Hepatic Flexure Cancer
Hydronephrosis Intestinal Obstruction
Intestinal Perforation Iron Deficiency Anemia
Paralytic Ileus Protein-Energy Malnutrition
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Rectosigmoid Junction Neoplasm:



Diseases related to Rectosigmoid Junction Neoplasm

Symptoms & Phenotypes for Rectosigmoid Junction Neoplasm

Drugs & Therapeutics for Rectosigmoid Junction Neoplasm

Drugs for Rectosigmoid Junction Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 4 154361-50-9 60953
2 Cola Phase 4
3 Antimetabolites Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open Label, Phase II Study of Capecitabine (Xeloda) Plus Conformal Radiotherapy for Patients With Locally Advanced, Non-Metastatic Rectosigmoid Carcinoma Terminated NCT00216424 Phase 4 Capecitabine (Xeloda)
2 Evaluation of the Role of Low Inferior Mesenteric Artery Ligation During Laparoscopic Surgery for Rectosigmoid Tumors Completed NCT03557528

Search NIH Clinical Center for Rectosigmoid Junction Neoplasm

Genetic Tests for Rectosigmoid Junction Neoplasm

Anatomical Context for Rectosigmoid Junction Neoplasm

MalaCards organs/tissues related to Rectosigmoid Junction Neoplasm:

40
Colon

Publications for Rectosigmoid Junction Neoplasm

Articles related to Rectosigmoid Junction Neoplasm:

# Title Authors PMID Year
1
Subjects older than 60 years with negative findings on sigmoidoscopy should still undergo colonoscopy. 61
12063966 2002
2
Malignant colorectal obstruction: treatment with a flexible covered stent. 61
9457194 1998
3
[Ileal obstruction following radiosurgical treatment for rectosigmoid neoplasm]. 61
7617904 1995

Variations for Rectosigmoid Junction Neoplasm

Expression for Rectosigmoid Junction Neoplasm

Search GEO for disease gene expression data for Rectosigmoid Junction Neoplasm.

Pathways for Rectosigmoid Junction Neoplasm

GO Terms for Rectosigmoid Junction Neoplasm

Biological processes related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual learning GO:0008542 8.62 TANC1 KRAS

Sources for Rectosigmoid Junction Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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