Rectosigmoid Junction Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Rectosigmoid Junction Neoplasm

MalaCards integrated aliases for Rectosigmoid Junction Neoplasm:

Name: Rectosigmoid Junction Neoplasm ¹² ¹⁵

Neoplasm of Rectosigmoid Junction ¹² ⁷¹

Rectosigmoid Neoplasm ¹² ⁷⁴

Malignant Tumor of Rectosigmoid Junction ⁷¹

Carcinoma of the Rectosigmoid Junction ⁷¹

Rectosigmoid Carcinoma ⁷¹

Rectosigmoid Tumor ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Cardiovascular diseases Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2780

NCIt ⁴⁹ C4877

SNOMED-CT ⁶⁷ 126848003

UMLS ⁷¹ C0153443 C0345873 C0559004 more

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Summaries for Rectosigmoid Junction Neoplasm

MalaCards based summary : Rectosigmoid Junction Neoplasm, also known as neoplasm of rectosigmoid junction, is related to rectosigmoid cancer and villous adenoma. An important gene associated with Rectosigmoid Junction Neoplasm is APOLD1 (Apolipoprotein L Domain Containing 1). The drugs Capecitabine and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon.

Wikipedia : ⁷⁴ Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development... more...

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Related Diseases for Rectosigmoid Junction Neoplasm

Diseases related to Rectosigmoid Junction Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)

#	Related Disease	Score	Top Affiliating Genes
1	rectosigmoid cancer	33.0	CEACAM5 APOLD1
2	villous adenoma	29.5	KRT20 CEACAM5 APOLD1
3	anal canal adenocarcinoma	10.2	KRT7 APOLD1
4	anus benign neoplasm	10.2	KRT7 APOLD1
5	anus cancer	10.1	KRT7 APOLD1
6	gastric signet ring cell adenocarcinoma	10.1	KRT7 KRT20
7	nephrogenic adenoma of urinary bladder	10.1	KRT7 KRT20
8	intrahepatic bile duct adenoma	10.1	KRT7 KRT20
9	bile duct adenoma	10.1	KRT7 KRT20
10	seminal vesicle adenocarcinoma	10.1	KRT7 KRT20
11	atrophic vulva	10.1	KRT7 KRT20
12	small cell carcinoma of the bladder	10.1	KRT7 KRT20
13	urinary bladder small cell neuroendocrine carcinoma	10.1	KRT7 KRT20
14	jejunal neoplasm	10.1	KRT7 KRT20
15	jejunal cancer	10.1	KRT7 KRT20
16	jejunal adenocarcinoma	10.1	KRT7 KRT20
17	intratubular embryonal carcinoma	10.1	KRT7 KRT20
18	adenoma	10.1
19	ovarian large-cell neuroendocrine carcinoma	10.1	KRT7 KRT20
20	papillary transitional carcinoma	10.1	KRT7 KRT20
21	meibomian cyst	10.1	KRT7 KRT20
22	ovarian brenner tumor	10.1	KRT7 KRT20
23	mucinous bronchioloalveolar adenocarcinoma	10.1	KRT7 KRT20
24	glandular cystitis	10.1	KRT7 KRT20
25	nephrogenic adenoma of the urethra	10.1	KRT7 KRT20
26	vaginal adenoma	10.1	KRT7 KRT20
27	thymus clear cell carcinoma	10.1	KRT7 KRT20
28	vaginal benign neoplasm	10.1	KRT7 KRT20
29	papillary cystadenocarcinoma	10.1	KRT7 KRT20
30	prostate neuroendocrine neoplasm	10.1	KRT7 KRT20
31	bladder lateral wall cancer	10.1	KRT7 KRT20
32	breast osteosarcoma	10.0	KRT7 KRT20
33	bladder clear cell adenocarcinoma	10.0	KRT7 KRT20
34	clear cell adenocarcinoma	10.0	KRT7 KRT20
35	bladder adenocarcinoma	10.0	KRT7 KRT20
36	horseshoe kidney	10.0	KRT7 KRT20
37	large intestine lipoma	10.0	CEACAM5 APOLD1
38	central epithelioid sarcoma	10.0	KRT7 KRT20
39	lipoma of colon	10.0	CEACAM5 APOLD1
40	vulvar proximal-type epithelioid sarcoma	10.0	KRT7 KRT20
41	peritoneal serous adenocarcinoma	10.0	KRT7 KRT20
42	rectum signet ring adenocarcinoma	10.0	CEACAM5 APOLD1
43	chronic cystitis	10.0	KRT7 KRT20
44	supine hypotensive syndrome	10.0	KRT7 KRT20
45	cystic basal cell carcinoma	10.0	KRT7 KRT20
46	descending colon cancer	10.0	CEACAM5 APOLD1
47	colon leiomyosarcoma	10.0	CEACAM5 APOLD1
48	retroperitoneum carcinoma	10.0	KRT7 KRT20
49	medulloepithelioma	10.0	KRT7 KRT20
50	ascending colon cancer	10.0	CEACAM5 APOLD1

Comorbidity relations with Rectosigmoid Junction Neoplasm via Phenotypic Disease Network (PDN): (show all 15)

Active Peptic Ulcer Disease	Acute Cystitis
Ascending Colon Cancer	Cecal Benign Neoplasm
Colorectal Cancer	Deficiency Anemia
Descending Colon Cancer	Hepatic Flexure Cancer
Hydronephrosis	Intestinal Obstruction
Intestinal Perforation	Iron Deficiency Anemia
Paralytic Ileus	Protein-Energy Malnutrition
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Rectosigmoid Junction Neoplasm:

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Symptoms & Phenotypes for Rectosigmoid Junction Neoplasm

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Drugs & Therapeutics for Rectosigmoid Junction Neoplasm

Drugs for Rectosigmoid Junction Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Capecitabine

Approved, Investigational

Phase 4

154361-50-9

60953

Synonyms:

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamate pentyl ester

(1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-carbamic acid pentyl ester

154361-50-9

158798-73-3

5'-Deoxy-5-fluoro-N-((pentyloxy)carbonyl)cytidine

5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine

AC1L1U83

AC1Q4KU8

Ambap154361-50-9

C110904

C12650

C15H22FN3O6

CAPE

Capecitabin

capecitabina

Capecitabina

capecitabine

Capecitabine

CAPECITABINE

Capécitabine

Capecitabine (JAN/USAN/INN)

Capecitabine [USAN]

capecitabinum

Capecitabinum

Capecitibine

Capiibine

Carbamic acid, (1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinyl)-, pentyl ester

Caxeta

CHEBI:31348

CHEMBL1773

CID60953

D01223

DB01101

FT-0082472

HSDB 7656

LS-59070

MolPort-005-938-254

N(4)-Pentyloxycarbonyl-5'-deoxy-5-fluorocytidine

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate

Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamic acid

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-beta-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate

Pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamic acid

pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate

R340

R-340

RG-340

Ro 09-1978

Ro 09-1978/000

Ro-09-1978

Ro-09-1978/000

S1156_Selleck

UNII-6804DJ8Z9U

Xabine

Xeloda

Xeloda (TN)

Xeloda, Captabin, Capecitabine

ZINC03806413

2

Cola

Phase 4

3

Antimetabolites

Phase 4

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	An Open Label, Phase II Study of Capecitabine (Xeloda) Plus Conformal Radiotherapy for Patients With Locally Advanced, Non-Metastatic Rectosigmoid Carcinoma	Terminated	NCT00216424	Phase 4	Capecitabine (Xeloda)

Search NIH Clinical Center for Rectosigmoid Junction Neoplasm

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Genetic Tests for Rectosigmoid Junction Neoplasm

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Anatomical Context for Rectosigmoid Junction Neoplasm

MalaCards organs/tissues related to Rectosigmoid Junction Neoplasm:

⁴⁰

Colon

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Publications for Rectosigmoid Junction Neoplasm

Articles related to Rectosigmoid Junction Neoplasm:

#	Title	Authors	PMID	Year
1	Subjects older than 60 years with negative findings on sigmoidoscopy should still undergo colonoscopy. ⁶¹	Yoshinaga M...Ikeda K	12063966	2002
2	Malignant colorectal obstruction: treatment with a flexible covered stent. ⁶¹	Choo IW...Kim SK	9457194	1998
3	[Ileal obstruction following radiosurgical treatment for rectosigmoid neoplasm]. ⁶¹	Cerrotta A...Zucali R	7617904	1995

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Genes for Rectosigmoid Junction Neoplasm

Genes related to Rectosigmoid Junction Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	APOLD1	Apolipoprotein L Domain Containing 1	Protein Coding	6.26	DISEASES inferred ¹⁵
2	ZNF750	Zinc Finger Protein 750	Protein Coding	5.69	DISEASES inferred ¹⁵
3	GTF2H5	General Transcription Factor IIH Subunit 5	Protein Coding	5.46	DISEASES inferred ¹⁵
4	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	5.44	DISEASES inferred ¹⁵
5	CDHR4	Cadherin Related Family Member 4	Protein Coding	5.31	DISEASES inferred ¹⁵
6	KRT20	Keratin 20	Protein Coding	5.22	DISEASES inferred ¹⁵
7	NCBP1	Nuclear Cap Binding Protein Subunit 1	Protein Coding	5.18	DISEASES inferred ¹⁵
8	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	5.12	DISEASES inferred ¹⁵
9	KRT7	Keratin 7	Protein Coding	4.94	DISEASES inferred ¹⁵

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Variations for Rectosigmoid Junction Neoplasm

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Expression for Rectosigmoid Junction Neoplasm

Search GEO for disease gene expression data for Rectosigmoid Junction Neoplasm.

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Pathways for Rectosigmoid Junction Neoplasm

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GO Terms for Rectosigmoid Junction Neoplasm

Biological processes related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	7-methylguanosine mRNA capping	GO:0006370	8.62	NCBP1 GTF2H5

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Sources for Rectosigmoid Junction Neoplasm

¹ BioSystems

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⁷⁴ Wikipedia