Rectosigmoid Junction Neoplasm

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Rectosigmoid Junction Neoplasm

MalaCards integrated aliases for Rectosigmoid Junction Neoplasm:

Name: Rectosigmoid Junction Neoplasm 12 15
Neoplasm of Rectosigmoid Junction 12 72
Rectosigmoid Neoplasm 12 75
Malignant Tumor of Rectosigmoid Junction 72
Carcinoma of the Rectosigmoid Junction 72
Rectosigmoid Carcinoma 72
Rectosigmoid Tumor 12


External Ids:

Disease Ontology 12 DOID:2780
NCIt 50 C4877
UMLS 72 C0153443 C0345873 C0559004 more

Summaries for Rectosigmoid Junction Neoplasm

MalaCards based summary : Rectosigmoid Junction Neoplasm, also known as neoplasm of rectosigmoid junction, is related to large intestine cancer and rectosigmoid cancer. An important gene associated with Rectosigmoid Junction Neoplasm is SIL1 (SIL1 Nucleotide Exchange Factor), and among its related pathways/superpathways are Busulfan Pathway, Pharmacodynamics and Doxorubicin Pathway, Pharmacokinetics. The drugs Capecitabine and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon.

Wikipedia : 75 Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from... more...

Related Diseases for Rectosigmoid Junction Neoplasm

Diseases related to Rectosigmoid Junction Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 large intestine cancer 28.0 SIL1 MSH2 MLH1 CEACAM6 CEACAM5 CD86
2 rectosigmoid cancer 12.0
3 appendix carcinoid tumor 10.4 MSH2 MLH1
4 colorectal cancer, hereditary nonpolyposis, type 7 10.4 MSH2 MLH1
5 adenosquamous colon carcinoma 10.4 MSH2 MLH1
6 lower lip cancer 10.4 MSH2 MLH1
7 sebaceous adenoma 10.4 MSH2 MLH1
8 anal fistula 10.4 MSH2 MLH1
9 melanocytic nevus syndrome, congenital 10.3 MSH2 MLH1
10 epididymis adenocarcinoma 10.3 CEACAM5 CD86
11 epididymis cancer 10.3 CEACAM5 CD86
12 gallbladder squamous cell carcinoma 10.3 CEACAM5 CD86
13 childhood kidney cell carcinoma 10.3 MSH2 MLH1
14 colorectal cancer, hereditary nonpolyposis, type 4 10.3 MSH2 MLH1
15 lymphohistiocytoid mesothelioma 10.3 CEACAM5 CD86
16 vulval paget's disease 10.3 CEACAM5 CD86
17 vulva adenocarcinoma 10.3 CEACAM5 CD86
18 cecum adenocarcinoma 10.3 MSH2 MLH1
19 cerebral primitive neuroectodermal tumor 10.3 MSH2 ENO2
20 lynch syndrome i 10.3 MSH2 MLH1
21 sebaceous adenocarcinoma 10.3 MSH2 MLH1
22 keratoacanthoma 10.2 MSH2 MLH1
23 descending colon cancer 10.2 MSH2 CEACAM5
24 muir-torre syndrome 10.2 MSH2 MLH1
25 small intestine cancer 10.2 MSH2 MLH1
26 melanotic medulloblastoma 10.2 ENO2 CEACAM5
27 atypical follicular adenoma 10.2 ENO2 CEACAM5
28 mismatch repair cancer syndrome 10.2 MSH2 MLH1
29 rete testis adenocarcinoma 10.2 ENO2 CEACAM5
30 gastric small cell carcinoma 10.2 ENO2 CEACAM5
31 colorectal cancer, hereditary nonpolyposis, type 5 10.2 MSH2 MLH1
32 mucinous ovarian cystadenoma 10.2 ENO2 CEACAM5
33 breast myoepithelial neoplasm 10.2 ENO2 CEACAM5
34 breast adenomyoepithelioma 10.2 ENO2 CEACAM5
35 familial colorectal cancer 10.2 MSH2 MLH1
36 rete testis neoplasm 10.2 ENO2 CEACAM5
37 chondroid chordoma 10.2 ENO2 CEACAM5
38 congenital epulis 10.1 ENO2 CEACAM5
39 mixed cell type cancer 10.1 ENO2 CEACAM5
40 mixed ductal-endocrine carcinoma 10.1 ENO2 CEACAM5
41 adenoma 10.1
42 tracheal cancer 10.1 ENO2 CEACAM5
43 alveolar soft part sarcoma 10.0 MLH1 ENO2
44 villous adenoma 10.0
45 colorectal adenoma 10.0 MSH2 MLH1
46 female reproductive system disease 10.0 MSH2 MLH1
47 skin benign neoplasm 10.0 MSH2 MLH1 ENO2
48 large cell carcinoma 10.0 ENO2 CEACAM5
49 intestinal benign neoplasm 9.9 MSH2 MLH1 CEACAM5
50 colonic disease 9.9 MSH2 MLH1 CEACAM5

Comorbidity relations with Rectosigmoid Junction Neoplasm via Phenotypic Disease Network (PDN): (show all 15)

Active Peptic Ulcer Disease Acute Cystitis
Ascending Colon Cancer Cecal Benign Neoplasm
Colorectal Cancer Deficiency Anemia
Descending Colon Cancer Hepatic Flexure Cancer
Hydronephrosis Intestinal Obstruction
Intestinal Perforation Iron Deficiency Anemia
Paralytic Ileus Protein-Energy Malnutrition
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Rectosigmoid Junction Neoplasm:

Diseases related to Rectosigmoid Junction Neoplasm

Symptoms & Phenotypes for Rectosigmoid Junction Neoplasm

Drugs & Therapeutics for Rectosigmoid Junction Neoplasm

Drugs for Rectosigmoid Junction Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

# Name Status Phase Clinical Trials Cas Number PubChem Id
Capecitabine Approved, Investigational Phase 4 154361-50-9 60953
2 Cola Phase 4
3 Antimetabolites, Antineoplastic Phase 4
4 Antimetabolites Phase 4

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 An Open Label, Phase II Study of Capecitabine (Xeloda) Plus Conformal Radiotherapy for Patients With Locally Advanced, Non-Metastatic Rectosigmoid Carcinoma Terminated NCT00216424 Phase 4 Capecitabine (Xeloda)

Search NIH Clinical Center for Rectosigmoid Junction Neoplasm

Genetic Tests for Rectosigmoid Junction Neoplasm

Anatomical Context for Rectosigmoid Junction Neoplasm

MalaCards organs/tissues related to Rectosigmoid Junction Neoplasm:


Publications for Rectosigmoid Junction Neoplasm

Articles related to Rectosigmoid Junction Neoplasm:

# Title Authors PMID Year
Subjects older than 60 years with negative findings on sigmoidoscopy should still undergo colonoscopy. 38
12063966 2002
Malignant colorectal obstruction: treatment with a flexible covered stent. 38
9457194 1998
[Ileal obstruction following radiosurgical treatment for rectosigmoid neoplasm]. 38
7617904 1995

Variations for Rectosigmoid Junction Neoplasm

Expression for Rectosigmoid Junction Neoplasm

Search GEO for disease gene expression data for Rectosigmoid Junction Neoplasm.

Pathways for Rectosigmoid Junction Neoplasm

GO Terms for Rectosigmoid Junction Neoplasm

Cellular components related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.62 MSH2 MLH1

Biological processes related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.48 MSH2 MLH1
2 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.46 CEACAM6 CEACAM5
3 mismatch repair GO:0006298 9.43 MSH2 MLH1
4 somatic hypermutation of immunoglobulin genes GO:0016446 9.4 MSH2 MLH1
5 negative regulation of anoikis GO:2000811 9.37 CEACAM6 CEACAM5
6 isotype switching GO:0045190 9.32 MSH2 MLH1
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.26 MSH2 MLH1
8 positive regulation of isotype switching to IgA isotypes GO:0048298 9.16 MSH2 MLH1
9 somatic recombination of immunoglobulin gene segments GO:0016447 8.96 MSH2 MLH1
10 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 8.62 MSH2 MLH1

Molecular functions related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 MSH2 MLH1
2 guanine/thymine mispair binding GO:0032137 8.62 MSH2 MLH1

Sources for Rectosigmoid Junction Neoplasm

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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