MCID: RCT008
MIFTS: 27

Rectosigmoid Junction Neoplasm

Categories: Cancer diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Rectosigmoid Junction Neoplasm

MalaCards integrated aliases for Rectosigmoid Junction Neoplasm:

Name: Rectosigmoid Junction Neoplasm 12 15
Neoplasm of Rectosigmoid Junction 12 71
Rectosigmoid Neoplasm 12 74
Malignant Tumor of Rectosigmoid Junction 71
Carcinoma of the Rectosigmoid Junction 71
Rectosigmoid Carcinoma 71
Rectosigmoid Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2780
NCIt 49 C4877
SNOMED-CT 67 126848003
UMLS 71 C0153443 C0345873 C0559004 more

Summaries for Rectosigmoid Junction Neoplasm

MalaCards based summary : Rectosigmoid Junction Neoplasm, also known as neoplasm of rectosigmoid junction, is related to rectosigmoid cancer and villous adenoma. An important gene associated with Rectosigmoid Junction Neoplasm is APOLD1 (Apolipoprotein L Domain Containing 1). The drugs Capecitabine and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon.

Wikipedia : 74 Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development... more...

Related Diseases for Rectosigmoid Junction Neoplasm

Diseases related to Rectosigmoid Junction Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
# Related Disease Score Top Affiliating Genes
1 rectosigmoid cancer 33.0 CEACAM5 APOLD1
2 villous adenoma 29.5 KRT20 CEACAM5 APOLD1
3 anal canal adenocarcinoma 10.2 KRT7 APOLD1
4 anus benign neoplasm 10.2 KRT7 APOLD1
5 anus cancer 10.1 KRT7 APOLD1
6 gastric signet ring cell adenocarcinoma 10.1 KRT7 KRT20
7 nephrogenic adenoma of urinary bladder 10.1 KRT7 KRT20
8 intrahepatic bile duct adenoma 10.1 KRT7 KRT20
9 bile duct adenoma 10.1 KRT7 KRT20
10 seminal vesicle adenocarcinoma 10.1 KRT7 KRT20
11 atrophic vulva 10.1 KRT7 KRT20
12 small cell carcinoma of the bladder 10.1 KRT7 KRT20
13 urinary bladder small cell neuroendocrine carcinoma 10.1 KRT7 KRT20
14 jejunal neoplasm 10.1 KRT7 KRT20
15 jejunal cancer 10.1 KRT7 KRT20
16 jejunal adenocarcinoma 10.1 KRT7 KRT20
17 intratubular embryonal carcinoma 10.1 KRT7 KRT20
18 adenoma 10.1
19 ovarian large-cell neuroendocrine carcinoma 10.1 KRT7 KRT20
20 papillary transitional carcinoma 10.1 KRT7 KRT20
21 meibomian cyst 10.1 KRT7 KRT20
22 ovarian brenner tumor 10.1 KRT7 KRT20
23 mucinous bronchioloalveolar adenocarcinoma 10.1 KRT7 KRT20
24 glandular cystitis 10.1 KRT7 KRT20
25 nephrogenic adenoma of the urethra 10.1 KRT7 KRT20
26 vaginal adenoma 10.1 KRT7 KRT20
27 thymus clear cell carcinoma 10.1 KRT7 KRT20
28 vaginal benign neoplasm 10.1 KRT7 KRT20
29 papillary cystadenocarcinoma 10.1 KRT7 KRT20
30 prostate neuroendocrine neoplasm 10.1 KRT7 KRT20
31 bladder lateral wall cancer 10.1 KRT7 KRT20
32 breast osteosarcoma 10.0 KRT7 KRT20
33 bladder clear cell adenocarcinoma 10.0 KRT7 KRT20
34 clear cell adenocarcinoma 10.0 KRT7 KRT20
35 bladder adenocarcinoma 10.0 KRT7 KRT20
36 horseshoe kidney 10.0 KRT7 KRT20
37 large intestine lipoma 10.0 CEACAM5 APOLD1
38 central epithelioid sarcoma 10.0 KRT7 KRT20
39 lipoma of colon 10.0 CEACAM5 APOLD1
40 vulvar proximal-type epithelioid sarcoma 10.0 KRT7 KRT20
41 peritoneal serous adenocarcinoma 10.0 KRT7 KRT20
42 rectum signet ring adenocarcinoma 10.0 CEACAM5 APOLD1
43 chronic cystitis 10.0 KRT7 KRT20
44 supine hypotensive syndrome 10.0 KRT7 KRT20
45 cystic basal cell carcinoma 10.0 KRT7 KRT20
46 descending colon cancer 10.0 CEACAM5 APOLD1
47 colon leiomyosarcoma 10.0 CEACAM5 APOLD1
48 retroperitoneum carcinoma 10.0 KRT7 KRT20
49 medulloepithelioma 10.0 KRT7 KRT20
50 ascending colon cancer 10.0 CEACAM5 APOLD1

Comorbidity relations with Rectosigmoid Junction Neoplasm via Phenotypic Disease Network (PDN): (show all 15)


Active Peptic Ulcer Disease Acute Cystitis
Ascending Colon Cancer Cecal Benign Neoplasm
Colorectal Cancer Deficiency Anemia
Descending Colon Cancer Hepatic Flexure Cancer
Hydronephrosis Intestinal Obstruction
Intestinal Perforation Iron Deficiency Anemia
Paralytic Ileus Protein-Energy Malnutrition
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Rectosigmoid Junction Neoplasm:



Diseases related to Rectosigmoid Junction Neoplasm

Symptoms & Phenotypes for Rectosigmoid Junction Neoplasm

Drugs & Therapeutics for Rectosigmoid Junction Neoplasm

Drugs for Rectosigmoid Junction Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 4 154361-50-9 60953
2 Cola Phase 4
3 Antimetabolites Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open Label, Phase II Study of Capecitabine (Xeloda) Plus Conformal Radiotherapy for Patients With Locally Advanced, Non-Metastatic Rectosigmoid Carcinoma Terminated NCT00216424 Phase 4 Capecitabine (Xeloda)

Search NIH Clinical Center for Rectosigmoid Junction Neoplasm

Genetic Tests for Rectosigmoid Junction Neoplasm

Anatomical Context for Rectosigmoid Junction Neoplasm

MalaCards organs/tissues related to Rectosigmoid Junction Neoplasm:

40
Colon

Publications for Rectosigmoid Junction Neoplasm

Articles related to Rectosigmoid Junction Neoplasm:

# Title Authors PMID Year
1
Subjects older than 60 years with negative findings on sigmoidoscopy should still undergo colonoscopy. 61
12063966 2002
2
Malignant colorectal obstruction: treatment with a flexible covered stent. 61
9457194 1998
3
[Ileal obstruction following radiosurgical treatment for rectosigmoid neoplasm]. 61
7617904 1995

Variations for Rectosigmoid Junction Neoplasm

Expression for Rectosigmoid Junction Neoplasm

Search GEO for disease gene expression data for Rectosigmoid Junction Neoplasm.

Pathways for Rectosigmoid Junction Neoplasm

GO Terms for Rectosigmoid Junction Neoplasm

Biological processes related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 7-methylguanosine mRNA capping GO:0006370 8.62 NCBP1 GTF2H5

Sources for Rectosigmoid Junction Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....