MCID: RCT008
MIFTS: 27

Rectosigmoid Junction Neoplasm

Categories: Cancer diseases, Cardiovascular diseases, Gastrointestinal diseases

Aliases & Classifications for Rectosigmoid Junction Neoplasm

MalaCards integrated aliases for Rectosigmoid Junction Neoplasm:

Name: Rectosigmoid Junction Neoplasm 12 15
Neoplasm of Rectosigmoid Junction 12 71
Rectosigmoid Neoplasm 12 74
Malignant Tumor of Rectosigmoid Junction 71
Carcinoma of the Rectosigmoid Junction 71
Rectosigmoid Carcinoma 71
Rectosigmoid Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2780
NCIt 49 C4877
UMLS 71 C0153443 C0345873 C0559004 more

Summaries for Rectosigmoid Junction Neoplasm

MalaCards based summary : Rectosigmoid Junction Neoplasm, also known as neoplasm of rectosigmoid junction, is related to rectosigmoid cancer and villous adenoma. An important gene associated with Rectosigmoid Junction Neoplasm is APOLD1 (Apolipoprotein L Domain Containing 1), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Capecitabine and Antimetabolites have been mentioned in the context of this disorder. Affiliated tissues include colon.

Wikipedia : 74 Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development... more...

Related Diseases for Rectosigmoid Junction Neoplasm

Diseases related to Rectosigmoid Junction Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 rectosigmoid cancer 33.1 CEACAM5 APOLD1
2 villous adenoma 30.0 CEACAM5 APOLD1
3 colon leiomyosarcoma 10.1 CEACAM5 APOLD1
4 rectum signet ring adenocarcinoma 10.1 CEACAM5 APOLD1
5 linitis plastica 10.1 CEACAM5 APOLD1
6 ascending colon cancer 10.1 CEACAM5 APOLD1
7 ovarian squamous cell carcinoma 10.1 CEACAM5 APOLD1
8 transverse colon cancer 10.1 CEACAM5 CDHR4
9 adenoma 10.1
10 large intestine lipoma 10.1 CEACAM5 APOLD1
11 colon sarcoma 10.1 CEACAM5 APOLD1
12 lipoma of colon 10.1 CEACAM5 APOLD1
13 hemorrhoid 10.0 CEACAM5 APOLD1
14 anus cancer 10.0 CEACAM5 APOLD1
15 rectum adenocarcinoma 10.0 CEACAM5 APOLD1
16 rectal disease 10.0 CEACAM5 APOLD1
17 large intestine cancer 9.9
18 myoblastoma 9.9 CEACAM6 CEACAM5
19 intestinal obstruction 9.9 CEACAM5 APOLD1
20 impotence 9.9
21 hypokalemia 9.9
22 intestinal benign neoplasm 9.9 CEACAM5 APOLD1
23 gastrointestinal system benign neoplasm 9.8 CEACAM5 APOLD1
24 gastrointestinal carcinoma 9.8 CEACAM6 CEACAM5
25 rectum cancer 9.6 CEACAM5 APOLD1
26 sigmoid neoplasm 8.3 TANC1 CSTB CEACAM6 CEACAM5 CDHR4 APOLD1

Comorbidity relations with Rectosigmoid Junction Neoplasm via Phenotypic Disease Network (PDN): (show all 15)


Active Peptic Ulcer Disease Acute Cystitis
Ascending Colon Cancer Cecal Benign Neoplasm
Colorectal Cancer Deficiency Anemia
Descending Colon Cancer Hepatic Flexure Cancer
Hydronephrosis Intestinal Obstruction
Intestinal Perforation Iron Deficiency Anemia
Paralytic Ileus Protein-Energy Malnutrition
Transverse Colon Cancer

Graphical network of the top 20 diseases related to Rectosigmoid Junction Neoplasm:



Diseases related to Rectosigmoid Junction Neoplasm

Symptoms & Phenotypes for Rectosigmoid Junction Neoplasm

Drugs & Therapeutics for Rectosigmoid Junction Neoplasm

Drugs for Rectosigmoid Junction Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 4 154361-50-9 60953
2 Antimetabolites Phase 4
3 Cola Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open Label, Phase II Study of Capecitabine (Xeloda) Plus Conformal Radiotherapy for Patients With Locally Advanced, Non-Metastatic Rectosigmoid Carcinoma Terminated NCT00216424 Phase 4 Capecitabine (Xeloda)

Search NIH Clinical Center for Rectosigmoid Junction Neoplasm

Genetic Tests for Rectosigmoid Junction Neoplasm

Anatomical Context for Rectosigmoid Junction Neoplasm

MalaCards organs/tissues related to Rectosigmoid Junction Neoplasm:

40
Colon

Publications for Rectosigmoid Junction Neoplasm

Articles related to Rectosigmoid Junction Neoplasm:

# Title Authors PMID Year
1
Subjects older than 60 years with negative findings on sigmoidoscopy should still undergo colonoscopy. 61
12063966 2002
2
Malignant colorectal obstruction: treatment with a flexible covered stent. 61
9457194 1998
3
[Ileal obstruction following radiosurgical treatment for rectosigmoid neoplasm]. 61
7617904 1995

Variations for Rectosigmoid Junction Neoplasm

Expression for Rectosigmoid Junction Neoplasm

Search GEO for disease gene expression data for Rectosigmoid Junction Neoplasm.

Pathways for Rectosigmoid Junction Neoplasm

Pathways related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.69 CEACAM6 CEACAM5

GO Terms for Rectosigmoid Junction Neoplasm

Cellular components related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anchored component of membrane GO:0031225 8.62 CEACAM6 CEACAM5

Biological processes related to Rectosigmoid Junction Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.43 CEACAM6 CEACAM5 CDHR4
2 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.16 CEACAM6 CEACAM5
3 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.13 CEACAM6 CEACAM5 CDHR4
4 negative regulation of anoikis GO:2000811 8.62 CEACAM6 CEACAM5

Sources for Rectosigmoid Junction Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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