MCID: RCT020
MIFTS: 34

Rectum Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Rectum Adenocarcinoma

MalaCards integrated aliases for Rectum Adenocarcinoma:

Name: Rectum Adenocarcinoma 12 15
Adenocarcinoma of Rectum 12 73
Rectal Adenocarcinoma 12 6

Classifications:



External Ids:

Disease Ontology 12 DOID:1996
NCIt 50 C9383
UMLS 73 C0149978

Summaries for Rectum Adenocarcinoma

Disease Ontology : 12 A rectum cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Rectum Adenocarcinoma, also known as adenocarcinoma of rectum, is related to rectal neoplasm and anal canal adenocarcinoma. An important gene associated with Rectum Adenocarcinoma is RAB11B (RAB11B, Member RAS Oncogene Family), and among its related pathways/superpathways is Cytoskeletal Signaling. Affiliated tissues include liver, colon and t cells.

Related Diseases for Rectum Adenocarcinoma

Diseases related to Rectum Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 rectal neoplasm 31.0 CAGE1 CEACAM5 DCXR KRT20 KRT7 SLC14A2
2 anal canal adenocarcinoma 30.2 CDX2 KRT7
3 mucinous adenocarcinoma 30.2 CDX2 KRT20 KRT7
4 signet ring cell adenocarcinoma 30.2 CDX2 KRT20 KRT7
5 villous adenoma 30.1 CDX2 KRT20
6 cystadenoma 30.0 KRT20 KRT7
7 mammary paget's disease 29.9 KRT20 KRT7
8 rectum signet ring adenocarcinoma 11.5
9 rectum mucinous adenocarcinoma 11.2
10 adenocarcinoma 10.4
11 colon adenocarcinoma 10.3
12 ovary neuroendocrine neoplasm 10.3 CDX2 KRT7
13 cecal benign neoplasm 10.3 KRT7 RAB11B
14 duodenum adenocarcinoma 10.2 CDX2 KRT7
15 anal canal carcinoma 10.2 KRT7 SLC14A2
16 epithelial predominant wilms' tumor 10.2 CDX2 KRT7
17 nasal cavity cancer 10.2 CDX2 KRT7
18 nasal cavity adenocarcinoma 10.2 CDX2 KRT7
19 cystic basal cell carcinoma 10.2 KRT20 KRT7
20 seminal vesicle adenocarcinoma 10.2 KRT20 KRT7
21 transverse colon cancer 10.2 KRT20 KRT7
22 malignant syringoma 10.2 KRT20 KRT7
23 papillary transitional carcinoma 10.2 KRT20 KRT7
24 vaginal benign neoplasm 10.2 CDX2 KRT20
25 eyelid carcinoma 10.2 KRT20 KRT7
26 krukenberg carcinoma 10.2 KRT20 KRT7
27 vaginal adenoma 10.2 CDX2 KRT20
28 large intestine adenocarcinoma 10.2 KRT20 KRT7
29 vaginal tubulovillous adenoma 10.2 CDX2 KRT20
30 linitis plastica 10.2 KRT20 KRT7
31 lung acinar adenocarcinoma 10.2 KRT20 KRT7
32 small cell carcinoma of the bladder 10.2 KRT20 KRT7
33 adenoid squamous cell carcinoma 10.2 KRT20 KRT7
34 intratubular embryonal carcinoma 10.2 KRT20 KRT7
35 duodenal disease 10.2 CDX2 KRT7
36 bile duct adenoma 10.2 KRT20 KRT7
37 bladder lymphoma 10.2 KRT20 KRT7
38 papillary serous adenocarcinoma 10.2 KRT20 KRT7
39 medulloepithelioma 10.2 KRT20 KRT7
40 glycogen-rich clear cell breast carcinoma 10.2 KRT20 KRT7
41 renal pelvis carcinoma 10.2 KRT20 KRT7
42 paget disease, extramammary 10.2 KRT20 KRT7
43 biliary tract neoplasm 10.2 CDX2 KRT7
44 papillary craniopharyngioma 10.2 DNAH12 KRT7
45 duodenum cancer 10.2 CDX2 KRT7
46 lymphoepithelioma-like carcinoma 10.2 KRT20 KRT7
47 hidradenocarcinoma 10.2 CDX2 KRT7
48 eccrine sweat gland neoplasm 10.2 KRT20 KRT7
49 dermoid cyst 10.2 KRT20 KRT7
50 cystadenofibroma 10.2 KRT20 KRT7

Graphical network of the top 20 diseases related to Rectum Adenocarcinoma:



Diseases related to Rectum Adenocarcinoma

Symptoms & Phenotypes for Rectum Adenocarcinoma

Drugs & Therapeutics for Rectum Adenocarcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fibroblast Before and After Neoadjuvant Chemo-radiotherapy in Patient With Locally Advanced Rectal Adenocarcinoma Recruiting NCT02849158 Not Applicable

Search NIH Clinical Center for Rectum Adenocarcinoma

Genetic Tests for Rectum Adenocarcinoma

Anatomical Context for Rectum Adenocarcinoma

MalaCards organs/tissues related to Rectum Adenocarcinoma:

41
Liver, Colon, T Cells, Lung, Prostate, Ovary, Thymus

Publications for Rectum Adenocarcinoma

Articles related to Rectum Adenocarcinoma:

(show all 21)
# Title Authors Year
1
A Rare Pattern of Lung Metastasis of Rectum Adenocarcinoma. ( 26784521 )
2016
2
Simultaneous robotic low anterior resection and prostatectomy for adenocarcinoma of rectum and prostate: initial case report. ( 27795910 )
2016
3
A randomized controlled pilot study to compare capecitabine-oxaliplatin with 5-FU-leucovorin as neoadjuvant concurrent chemoradiation in locally advanced adenocarcinoma of rectum. ( 25879343 )
2015
4
Scrotal skin metastasis from rectum adenocarcinoma. ( 24416494 )
2013
5
Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review. ( 22429319 )
2013
6
Metastasis to ileostomy of mucinous adenocarcinoma of rectum. ( 24392566 )
2013
7
Adenocarcinoma of rectum as second primary cancer after treatment of endometrium cancer. ( 23763808 )
2013
8
Mucinous adenocarcinoma of rectum in an 11-year-old boy: a case report. ( 21416643 )
2012
9
Adjuvant modified FOLFOX-4 in patients with stage III rectum adenocarcinoma. ( 21790235 )
2011
10
Association between human papillomavirus and adenocarcinoma of rectum and recto-sigmoid junction: a cohort study of 10,612 women in Taiwan. ( 20721617 )
2010
11
Synchronous isolated adrenal metastasis from rectum adenocarcinoma. ( 19380305 )
2009
12
Adenocarcinoma of rectum metastasizing to penis. ( 11771091 )
2001
13
Villous adenoma of urethra associated with tubulovillous adenoma and adenocarcinoma of rectum. ( 9522225 )
1998
14
Surgical treatment of colon and rectum adenocarcinoma in elderly patients. ( 1434647 )
1992
15
Establishment and characterization of a cell line HR-8348 derived from human poorly differentiated adenocarcinoma of rectum. ( 3672101 )
1987
16
Tumour basement membrane laminin in adenocarcinoma of rectum: an immunohistochemical study of biological and clinical significance. ( 3519472 )
1986
17
Case profile: priapism secondary to metastatic adenocarcinoma of rectum. ( 4012965 )
1985
18
Signet-ring cell adenocarcinoma of rectum: a histological, histochemical and electron microscopic study. ( 6284632 )
1982
19
Multiple metastases in muscle from adenocarcinoma of rectum. ( 14479319 )
1961
20
[Metastatic adenocarcinoma of lymph nodes around bile ducts from previously resected adenocarcinoma of rectum]. ( 20248437 )
1947
21
[Adenocarcinoma of rectum]. ( 20265315 )
1947

Variations for Rectum Adenocarcinoma

ClinVar genetic disease variations for Rectum Adenocarcinoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 APC NM_000038.5(APC): c.811A> G (p.Met271Val) single nucleotide variant Uncertain significance rs587781464 GRCh37 Chromosome 5, 112137057: 112137057
2 APC NM_000038.5(APC): c.811A> G (p.Met271Val) single nucleotide variant Uncertain significance rs587781464 GRCh38 Chromosome 5, 112801360: 112801360
3 APC NM_000038.5(APC): c.1984C> A (p.Leu662Ile) single nucleotide variant Uncertain significance rs756859993 GRCh37 Chromosome 5, 112173275: 112173275
4 APC NM_000038.5(APC): c.1984C> A (p.Leu662Ile) single nucleotide variant Uncertain significance rs756859993 GRCh38 Chromosome 5, 112837578: 112837578
5 APC NM_000038.5(APC): c.6152A> G (p.Lys2051Arg) single nucleotide variant Uncertain significance GRCh37 Chromosome 5, 112177443: 112177443
6 APC NM_000038.5(APC): c.6152A> G (p.Lys2051Arg) single nucleotide variant Uncertain significance GRCh38 Chromosome 5, 112841746: 112841746
7 APC NM_001127510.2(APC): c.3160C> T (p.His1054Tyr) single nucleotide variant Uncertain significance GRCh37 Chromosome 5, 112174451: 112174451
8 APC NM_001127510.2(APC): c.3160C> T (p.His1054Tyr) single nucleotide variant Uncertain significance GRCh38 Chromosome 5, 112838754: 112838754

Expression for Rectum Adenocarcinoma

Search GEO for disease gene expression data for Rectum Adenocarcinoma.

Pathways for Rectum Adenocarcinoma

Pathways related to Rectum Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 KRT20 KRT7 RAB11B RAB1A

GO Terms for Rectum Adenocarcinoma

Biological processes related to Rectum Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome transport GO:0032402 8.62 RAB11B RAB1A

Sources for Rectum Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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