MCID: RCT020
MIFTS: 35

Rectum Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Rectum Adenocarcinoma

MalaCards integrated aliases for Rectum Adenocarcinoma:

Name: Rectum Adenocarcinoma 12 15
Adenocarcinoma of Rectum 12 73
Rectal Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1996
NCIt 50 C9383
SNOMED-CT 68 254582000
UMLS 73 C0149978

Summaries for Rectum Adenocarcinoma

Disease Ontology : 12 A rectum cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Rectum Adenocarcinoma, also known as adenocarcinoma of rectum, is related to rectal neoplasm and rectum signet ring adenocarcinoma. An important gene associated with Rectum Adenocarcinoma is RAB11B (RAB11B, Member RAS Oncogene Family), and among its related pathways/superpathways is Cytoskeletal Signaling. The drugs Capecitabine and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and lung.

Related Diseases for Rectum Adenocarcinoma

Diseases related to Rectum Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 rectal neoplasm 29.1 CAGE1 CEACAM5 DCXR KRT20 KRT7 SLC14A2
2 rectum signet ring adenocarcinoma 11.4
3 rectum mucinous adenocarcinoma 11.0
4 cecal benign neoplasm 10.8 KRT7 RAB11B
5 ovary neuroendocrine neoplasm 10.8 CDX2 KRT7
6 epithelial predominant wilms' tumor 10.8 CDX2 KRT7
7 papillary craniopharyngioma 10.7 DNAH12 KRT7
8 cystic basal cell carcinoma 10.7 KRT20 KRT7
9 bronchiolo-alveolar adenocarcinoma 10.7 CDX2 KRT7
10 seminal vesicle adenocarcinoma 10.7 KRT20 KRT7
11 transverse colon cancer 10.7 KRT20 KRT7
12 ovarian large-cell neuroendocrine carcinoma 10.7 KRT20 KRT7
13 eyelid neoplasm 10.7 KRT20 KRT7
14 malignant syringoma 10.7 KRT20 KRT7
15 nasal cavity adenocarcinoma 10.7 CDX2 KRT7
16 krukenberg carcinoma 10.7 KRT20 KRT7
17 large intestine adenocarcinoma 10.7 KRT20 KRT7
18 linitis plastica 10.7 KRT20 KRT7
19 lung acinar adenocarcinoma 10.7 KRT20 KRT7
20 anal canal adenocarcinoma 10.7 CDX2 KRT7
21 small cell carcinoma of the bladder 10.7 KRT20 KRT7
22 adenoid squamous cell carcinoma 10.7 KRT20 KRT7
23 eccrine sweat gland neoplasm 10.7 KRT20 KRT7
24 intratubular embryonal carcinoma 10.7 KRT20 KRT7
25 bladder lymphoma 10.7 KRT20 KRT7
26 papillary serous adenocarcinoma 10.7 KRT20 KRT7
27 medulloepithelioma 10.7 KRT20 KRT7
28 glycogen-rich clear cell breast carcinoma 10.7 KRT20 KRT7
29 renal pelvis carcinoma 10.7 KRT20 KRT7
30 paget disease, extramammary 10.6 KRT20 KRT7
31 mucinous cystadenocarcinoma 10.6 KRT20 KRT7
32 biliary tract neoplasm 10.6 CDX2 KRT7
33 duodenum cancer 10.6 CDX2 KRT7
34 villous adenoma 10.6 CDX2 KRT20
35 lymphoepithelioma-like carcinoma 10.6 KRT20 KRT7
36 dermoid cyst 10.6 KRT20 KRT7
37 hidradenocarcinoma 10.6 CDX2 KRT7
38 cystadenofibroma 10.6 KRT20 KRT7
39 inverted papilloma 10.5 KRT20 KRT7
40 gastric tubular adenocarcinoma 10.5 CDX2 KRT7
41 ovarian cystic teratoma 10.5 KRT20 KRT7
42 anus cancer 10.5 CDX2 KRT7 SLC14A2
43 large cell neuroendocrine carcinoma 10.5 KRT20 KRT7
44 mammary paget's disease 10.5 KRT20 KRT7
45 hypotrichosis 3 10.5 RAB11B RAB1A
46 benign mesothelioma 10.4 KRT20 KRT7
47 vaginal benign neoplasm 10.4 CDX2 KRT20 KRT7
48 appendix adenocarcinoma 10.4 CDX2 KRT20 KRT7
49 vaginal adenoma 10.4 CDX2 KRT20 KRT7
50 vaginal tubulovillous adenoma 10.4 CDX2 KRT20 KRT7

Graphical network of the top 20 diseases related to Rectum Adenocarcinoma:



Diseases related to Rectum Adenocarcinoma

Symptoms & Phenotypes for Rectum Adenocarcinoma

Drugs & Therapeutics for Rectum Adenocarcinoma

Drugs for Rectum Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 237)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 154361-50-9 60953
2
Fluorouracil Approved Phase 3,Phase 2,Phase 1,Not Applicable 51-21-8 3385
3
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 61825-94-3 5310940 9887054 43805 6857599
4
Levoleucovorin Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 68538-85-2
5
Cetuximab Approved Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 205923-56-4 56842117 2333
6
Irinotecan Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 97682-44-5, 100286-90-6 60838
7
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
8
Raltitrexed Approved, Investigational Phase 3,Phase 2 112887-68-0 104758
9
Celecoxib Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 169590-42-5 2662
10
Bevacizumab Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 216974-75-3
11
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
12 lanreotide Approved Phase 3 108736-35-2
13
Tegafur Approved, Investigational Phase 3,Phase 2 17902-23-7 5386
14
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
15
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
16
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
17
Floxuridine Approved Phase 3,Phase 2,Phase 1 50-91-9 5790
18
Histamine Approved, Investigational Phase 3,Phase 2 75614-87-8, 51-45-6 774
19
Trioxsalen Approved Phase 2, Phase 3 3902-71-4 5585
20
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
21
Promethazine Approved, Investigational Phase 3 60-87-7 4927
22
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
24
Camptothecin Experimental Phase 3,Phase 2,Phase 1 7689-03-4
25
Eniluracil Investigational Phase 3 59989-18-3
26
Doxil Approved June 1999 Phase 3,Phase 2 31703
27 Antimetabolites Phase 3,Phase 2,Phase 1,Not Applicable
28 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1,Not Applicable
29 Disinfectants Phase 3
30 Antidotes Phase 3,Phase 2,Phase 1,Not Applicable
31 Calcium, Dietary Phase 3,Phase 2,Phase 1,Not Applicable
32
Cobalt Phase 3 7440-48-4 104729
33 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
34 Protective Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 Antibodies Phase 3,Phase 2,Phase 1,Early Phase 1
36 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1,Early Phase 1
37 Antifungal Agents Phase 3,Phase 2
38 Anti-Infective Agents Phase 3,Phase 1,Phase 2
39 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
40 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
41 Calcineurin Inhibitors Phase 3,Phase 2
42 Cyclosporins Phase 3,Phase 2
43 Dermatologic Agents Phase 3,Phase 2
44 Immunoglobulins Phase 3,Phase 2,Phase 1,Early Phase 1
45 topoisomerase I inhibitors Phase 3,Phase 2,Phase 1
46 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
47 Angiogenesis Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
48 Angiogenesis Modulating Agents Phase 3,Phase 2,Phase 1,Not Applicable
49 Protein Kinase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
50 Semaxinib Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 374)
# Name Status NCT ID Phase Drugs
1 A Study Comparing Adjuvant Chemotherapy Versus Observation for Patients With Rectal Adenocarcinoma After Neoadjuvant Chemo-Radiotherapy Treatment. Unknown status NCT01941979 Phase 3 5-FU, Capecitabine, Oxaliplatin, Leucovorin.
2 Resource-Sparing Curative Treatment for Rectal Cancer Unknown status NCT01459328 Phase 3
3 J-Pouch Coloanal Anastomosis Compared With Side-to-End Coloanal Anastomosis After Radiation Therapy and Surgery to Remove the Rectum in Treating Patients With Rectal Adenocarcinoma Unknown status NCT00070005 Phase 3
4 Radiation Therapy and Capecitabine With or Without Oxaliplatin in Treating Patients Who Are Undergoing Surgery for Stage II or Stage III Rectal Cancer Unknown status NCT00227747 Phase 3 capecitabine;oxaliplatin
5 Radiation Therapy Plus Chemotherapy Before Surgery With or Without Chemotherapy After Surgery in Treating Patients With Rectal Cancer Unknown status NCT00002896 Phase 3 chemotherapy;fluorouracil;leucovorin calcium
6 Laparoscopic Anterior Resection With or Without "Dog Ear" Double-stapled Anastomosis for Rectal Cancer Unknown status NCT02770911 Phase 3
7 COLOR II: Laparoscopic Versus Open Rectal Cancer Removal Unknown status NCT00297791 Phase 3
8 Neoadjuvant Radiotherapy Followed by Transanal Endoscopic Microsurgery for T1-T2 Extraperitoneal Rectal Cancer Unknown status NCT02127645 Phase 3
9 Radiation Therapy and Either Capecitabine or Fluorouracil With or Without Oxaliplatin Before Surgery in Treating Patients With Resectable Rectal Cancer Unknown status NCT00058474 Phase 3 capecitabine;fluorouracil;oxaliplatin
10 Combination Chemotherapy With or Without Cetuximab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00182715 Phase 3 capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
11 Leucovorin and Fluorouracil With or Without Oxaliplatin Compared to Capecitabine With or Without Oxaliplatin in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00070213 Phase 3 FOLFOX regimen;capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
12 Irinotecan With or Without Panitumumab or Cyclosporine in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Fluorouracil Unknown status NCT00389870 Phase 3 cyclosporine;irinotecan hydrochloride
13 Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery Unknown status NCT00274872 Phase 2, Phase 3 fluorouracil;leucovorin calcium;oxaliplatin
14 Combination Chemotherapy in Treating Patients With Recurrent Metastatic Colorectal Cancer Unknown status NCT00003260 Phase 3 FOLFIRI regimen;FOLFOX regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
15 Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00021281 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;semaxanib
16 Comparison of Three Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00008281 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
17 Comparing Two Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer Unknown status NCT00006468 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
18 A Randomized Controlled Clinical Trial Comparing Oncological Results and Functional Recovery Between Laparoscopic and Open Method for the Treatment of Advanced Rectal Cancer After Concurrent Chemoradiation Therapy (CCRT) Unknown status NCT00601549 Phase 3
19 Combination Chemotherapy With or Without Cetuximab Before and After Surgery in Treating Patients With Resectable Liver Metastases Caused By Colorectal Cancer Unknown status NCT00482222 Phase 3 capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
20 Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver Unknown status NCT00002692 Phase 3 fluorouracil;isolated perfusion;leucovorin calcium
21 Palliative Chemotherapy in Treating Patients With Advanced Colorectal Cancer Unknown status NCT00002893 Phase 3 fluorouracil;leucovorin calcium;raltitrexed
22 A Randomised Trial of Preoperative Radiotherapy for Stage T3 Adenocarcinoma of Rectum Completed NCT00145769 Phase 3 Short Course Adjuvent Chemotherapy;Long Course Adjuvant Chemotherapy;Concurrent Chemotherapy
23 Influence of Somatuline Autogel 120mg on Post-operative Drainage After Total Mesorectum Excision for Rectumcarcinoma Completed NCT01372007 Phase 3 Lanreotide Autogel 120mg;Placebo
24 Sphincter-preserving Surgery After Preoperative Treatment of Ultra-low Rectal Carcinoma Completed NCT00979680 Phase 3
25 Laparoscopic Assisted Versus Open Resection for Colorectal Carcinoma Completed NCT00485316 Phase 3
26 Capecitabine and Oxaliplatin or Standard Follow-Up Care in Treating Patients Who Have Undergone Surgery for Locally Advanced Rectal Cancer Completed NCT00427713 Phase 3 capecitabine;oxaliplatin
27 Chemotherapy and Radiation Therapy Before Surgery Followed by Capecitabine With or Without Oxaliplatin in Treating Patients With Locally Advanced Rectal Cancer Completed NCT00766155 Phase 3 capecitabine;oxaliplatin
28 Radiation Therapy With or Without Chemotherapy Before Surgery in Treating Patients With Stage II or Stage III Rectal Cancer Completed NCT00296608 Phase 3 fluorouracil;leucovorin calcium
29 SWOG-9304 Chemotherapy Plus Radiation Therapy in Treating Patients With Rectal Cancer That Has Been Surgically Removed Completed NCT00002551 Phase 3 fluorouracil;leucovorin calcium;levamisole hydrochloride
30 Radiation Therapy, Surgery, and Chemotherapy in Treating Patients With Rectal Cancer That Can Be Surgically Removed Completed NCT00002523 Phase 3 fluorouracil;leucovorin calcium
31 Combination Chemotherapy With or Without Celecoxib in Treating Patients With Metastatic Colorectal Cancer Completed NCT00064181 Phase 3 FOLFIRI regimen;capecitabine;celecoxib;fluorouracil;irinotecan hydrochloride;leucovorin calcium
32 Tegafur-Uracil or Observation in Treating Patients With Stage II Colorectal Cancer That Has Been Completely Removed By Surgery Completed NCT00392899 Phase 3 UFT adjuvant chemotherapy
33 Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients Following Surgery for Stage III Colorectal Cancer Completed NCT00026273 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
34 Radiation Therapy Before Surgery Compared With Chemotherapy Plus Radiation After Surgery in Treating Patients With Rectal Cancer That Can Be Surgically Removed Completed NCT00003422 Phase 3 fluorouracil;leucovorin calcium
35 Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer Completed NCT00005036 Phase 3 irinotecan hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil
36 Fluorouracil With or Without Eniluracil in Treating Patients With Advanced Colorectal Cancer Completed NCT00003873 Phase 3 fluorouracil;eniluracil
37 Combination Chemotherapy in Treating Patients With Colorectal Cancer and Resectable Metastases Completed NCT00268398 Phase 3 oxaliplatin, folinic acid, fluorouracil;oxaliplatin, irinotecan, folinic acid, fluorouracil
38 Optimized Chemotherapy Followed by Maintenance With Bevacizumab With or Without Erlotinib in Treating Patients With Metastatic Colorectal Cancer That Cannot be Removed by Surgery (DREAM) Completed NCT00265824 Phase 3 bevacizumab;bevacizumab, erlotinib
39 Efficiency of Two Dimensional High Definition Versus Three Dimensional Endoscopic Systems in Transanal Endoscopic Surgery Completed NCT01498354 Phase 3
40 Combination Chemotherapy With or Without Bevacizumab Compared With Bevacizumab Alone in Treating Patients With Advanced or Metastatic Colorectal Cancer That Has Been Previously Treated Completed NCT00025337 Phase 3 oxaliplatin;leucovorin calcium;fluorouracil
41 Combination Chemotherapy as First-Line Therapy in Treating Older Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery Completed NCT00303771 Phase 3 fluorouracil;irinotecan hydrochloride;leucovorin calcium
42 Oxaliplatin and Bevacizumab (Avastin™) With Either Fluorouracil and Leucovorin or Capecitabine in Treating Patients With Advanced Colorectal Cancer Completed NCT00062426 Phase 3 capecitabine;fluorouracil;leucovorin calcium;oxaliplatin
43 Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients With Metastatic Colorectal Cancer Completed NCT00004885 Phase 3 FOLFIRI regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium
44 Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer Completed NCT00003287 Phase 3 FOLFOX regimen;fluorouracil;leucovorin calcium;oxaliplatin
45 Combination Chemotherapy in Treating Patients With Unresectable Metastatic Colorectal Cancer Completed NCT00008060 Phase 3 FOLFIRI regimen;FOLFOX regimen;fluorouracil;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
46 Rectal Reconstruction in Treating Patients Who Are Undergoing Surgery for Rectal Cancer Completed NCT00238381 Phase 3
47 Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal Cancer Completed NCT00975897 Phase 2, Phase 3 fluorouracil;irinotecan hydrochloride;leucovorin calcium;oxaliplatin
48 Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy Completed NCT01099449 Phase 3 calcium gluconate;magnesium sulfate;oxaliplatin
49 Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery Completed NCT00316914 Phase 3 calcium gluconate;magnesium sulfate
50 Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver Completed NCT00023868 Phase 3 FOLFIRI regimen;cisplatin;doxorubicin hydrochloride;fluorouracil;irinotecan hydrochloride;leucovorin calcium;mitomycin C

Search NIH Clinical Center for Rectum Adenocarcinoma

Genetic Tests for Rectum Adenocarcinoma

Anatomical Context for Rectum Adenocarcinoma

MalaCards organs/tissues related to Rectum Adenocarcinoma:

41
Liver, Colon, Lung, Testes, Nk Cells, Endothelial, Thyroid

Publications for Rectum Adenocarcinoma

Articles related to Rectum Adenocarcinoma:

# Title Authors Year
1
A Rare Pattern of Lung Metastasis of Rectum Adenocarcinoma. ( 26784521 )
2016
2
Scrotal skin metastasis from rectum adenocarcinoma. ( 24416494 )
2013
3
Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review. ( 22429319 )
2013
4
Metastasis to ileostomy of mucinous adenocarcinoma of rectum. ( 24392566 )
2013
5
Mucinous adenocarcinoma of rectum in an 11-year-old boy: a case report. ( 21416643 )
2012
6
Adjuvant modified FOLFOX-4 in patients with stage III rectum adenocarcinoma. ( 21790235 )
2011
7
Synchronous isolated adrenal metastasis from rectum adenocarcinoma. ( 19380305 )
2009
8
Surgical treatment of colon and rectum adenocarcinoma in elderly patients. ( 1434647 )
1992
9
Signet-ring cell adenocarcinoma of rectum: a histological, histochemical and electron microscopic study. ( 6284632 )
1982

Variations for Rectum Adenocarcinoma

Expression for Rectum Adenocarcinoma

Search GEO for disease gene expression data for Rectum Adenocarcinoma.

Pathways for Rectum Adenocarcinoma

Pathways related to Rectum Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.41 KRT20 KRT7 RAB11B RAB1A

GO Terms for Rectum Adenocarcinoma

Biological processes related to Rectum Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome transport GO:0032402 8.62 RAB11B RAB1A

Sources for Rectum Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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