Rectum Adenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Rectum Adenoma

MalaCards integrated aliases for Rectum Adenoma:

Name: Rectum Adenoma ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050915

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Summaries for Rectum Adenoma

Disease Ontology : ¹² An rectal neoplasm that has material basis in epithelial tissue with glandular origin.

MalaCards based summary : Rectum Adenoma is related to adenoma and peutz-jeghers syndrome. An important gene associated with Rectum Adenoma is JTB (Jumping Translocation Breakpoint). The drug Cola has been mentioned in the context of this disorder. Affiliated tissues include colon, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Rectum Adenoma

Diseases related to Rectum Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	adenoma	10.4
2	peutz-jeghers syndrome	9.9
3	villous adenoma	9.9
4	diarrhea	9.9
5	squamous cell carcinoma	9.9
6	in situ carcinoma	9.9

Graphical network of the top 20 diseases related to Rectum Adenoma:

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Symptoms & Phenotypes for Rectum Adenoma

GenomeRNAi Phenotypes related to Rectum Adenoma according to GeneCards Suite gene sharing:

²⁶ (show all 18)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.86	TGFBR2
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-12	9.86	TGFBR2
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-132	9.86	TGFBR2
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-147	9.86	TGFBR2
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	9.86	S100A10
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-162	9.86	TGFBR2
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-165	9.86	TGFBR2
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-186	9.86	TGFBR2
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-188	9.86	TGFBR2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-3	9.86	S100A10
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-39	9.86	TGFBR2
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-48	9.86	TGFBR2
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-60	9.86	TGFBR2
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.86	S100A10
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-7	9.86	TGFBR2
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-8	9.86	S100A10
17	Increased NF-kappaB reporter expression	GR00312-A	9.16	JTB TGFBR2
18	Nuclear 60S biogenesis defects	GR00209-A-3	8.62	RPL19 RPL27A

MGI Mouse Phenotypes related to Rectum Adenoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	8.92	JTB RPL27A S100A10 TGFBR2

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Drugs & Therapeutics for Rectum Adenoma

Drugs for Rectum Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Cola

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Colorectal Cancer Screening in Norway: Pilot Study of a National Screening Programme With Randomised Comparison of Different Screening Strategies to Provide the Best Possible Service to the Population	Active, not recruiting	NCT01538550

Search NIH Clinical Center for Rectum Adenoma

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Genetic Tests for Rectum Adenoma

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Anatomical Context for Rectum Adenoma

MalaCards organs/tissues related to Rectum Adenoma:

⁴⁰

Colon

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Publications for Rectum Adenoma

Articles related to Rectum Adenoma:

#	Title	Authors	PMID	Year
1	Metformin use and the risk of colorectal adenoma: A systematic review and meta-analysis. ⁶¹	Jung YS...Han DS	28449338	2017
2	Endoscopic mucosal resection of flat and sessile colorectal adenomas: our experience with long-term follow-ups. ⁶¹	Grgov S...Tasic T	24516988	2014
3	Meat, meat cooking methods and preservation, and risk for colorectal adenoma. ⁶¹	Sinha R...Hayes RB	16140978	2005
4	[Treatment of rectum adenoma. Retrospective study of the treatment of inpatients (1987-1991)]. ⁶¹	Richter M...Tondelli P	8701268	1996
5	[Differential diagnosis at the bedside - villous rectum adenoma. Main symptom "diarrhea"]. ⁶¹	Kuntz HD	6796881	1981
6	[Pathology and classification of colorectal polyps]. ⁶¹	Fischer R...Bohr M	451434	1979
7	[Elektrolyte-losing rectum adenoma (author's transl)]. ⁶¹	Werner G...Usbeck W	636701	1978
8	Malignant adenomas of the colon and rectum; (adenoma malignum). ⁶¹	McELWEE RS...MOORE SW	14891072	1951

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Genes for Rectum Adenoma

Genes related to Rectum Adenoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	JTB	Jumping Translocation Breakpoint	Protein Coding	5.5	DISEASES inferred ¹⁵
2	RPL27A	Ribosomal Protein L27a	Protein Coding	5.37	DISEASES inferred ¹⁵
3	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	4.92	DISEASES inferred ¹⁵
4	RPL19	Ribosomal Protein L19	Protein Coding	4.69	DISEASES inferred ¹⁵
5	S100A10	S100 Calcium Binding Protein A10	Protein Coding	4.34	DISEASES inferred ¹⁵

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Variations for Rectum Adenoma

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Expression for Rectum Adenoma

Search GEO for disease gene expression data for Rectum Adenoma.

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Pathways for Rectum Adenoma

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GO Terms for Rectum Adenoma

Cellular components related to Rectum Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	membrane raft	GO:0045121	9.16	TGFBR2 S100A10
2	ribosome	GO:0005840	8.96	RPL27A RPL19
3	cytosolic large ribosomal subunit	GO:0022625	8.62	RPL27A RPL19

Biological processes related to Rectum Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	translational initiation	GO:0006413	9.26	RPL27A RPL19
2	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	GO:0000184	9.16	RPL27A RPL19
3	viral transcription	GO:0019083	8.96	RPL27A RPL19
4	SRP-dependent cotranslational protein targeting to membrane	GO:0006614	8.62	RPL27A RPL19

Molecular functions related to Rectum Adenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural constituent of ribosome	GO:0003735	8.62	RPL27A RPL19

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Sources for Rectum Adenoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia