MCID: RCT005
MIFTS: 35

Rectum Neuroendocrine Neoplasm

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Rectum Neuroendocrine Neoplasm

MalaCards integrated aliases for Rectum Neuroendocrine Neoplasm:

Name: Rectum Neuroendocrine Neoplasm 12 15
Neuroendocrine Tumor of the Rectum 58
Neuroendocrine Tumor of Rectum 12
Rectal Neuroendocrine Neoplasm 71
Rectal Neuroendocrine Tumor 58
Net of the Rectum 58
Rectal Net 58

Classifications:

Orphanet: 58  
Rare gastroenterological diseases
Rare endocrine diseases


Summaries for Rectum Neuroendocrine Neoplasm

MalaCards based summary : Rectum Neuroendocrine Neoplasm, also known as neuroendocrine tumor of the rectum, is related to rectum adenocarcinoma and villous adenoma. An important gene associated with Rectum Neuroendocrine Neoplasm is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways is Gastric acid production. The drugs Hyaluronic acid and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and colon, and related phenotypes are weight loss and abdominal pain

Related Diseases for Rectum Neuroendocrine Neoplasm

Diseases related to Rectum Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 rectum adenocarcinoma 30.1 KRT7 CDX2
2 villous adenoma 29.9 SST CDX2
3 carcinoid syndrome 29.7 SYP SST
4 constipation 29.2 VIP SST GAST
5 carcinoid tumors, intestinal 29.1 SYP SST GAST
6 neuroendocrine tumor 29.0 VIP SYP SST GAST CDX2
7 neuroendocrine carcinoma 28.9 SYP SST KRT7 GAST
8 adenoma 28.7 SYP SST KRT7 CDX2
9 anal canal paget's disease 10.2 KRT7 CDX2
10 anal paget's disease 10.2 KRT7 CDX2
11 anal gland adenocarcinoma 10.2 KRT7 CDX2
12 ureter adenocarcinoma 10.2 KRT7 CDX2
13 gastric signet ring cell adenocarcinoma 10.2 KRT7 CDX2
14 signet ring cell adenocarcinoma 10.2 KRT7 CDX2
15 pancreatic foamy gland adenocarcinoma 10.2 KRT7 CDX2
16 adenosquamous colon carcinoma 10.2 KRT7 CDX2
17 nasal cavity adenocarcinoma 10.2 KRT7 CDX2
18 anus adenocarcinoma 10.2 KRT7 CDX2
19 seminal vesicle adenocarcinoma 10.2 KRT7 CDX2
20 urinary bladder villous adenoma 10.2 KRT7 CDX2
21 bartholin's gland carcinoma 10.2 KRT7 CDX2
22 vulva adenocarcinoma 10.2 KRT7 CDX2
23 cystitis cystica 10.2 KRT7 CDX2
24 mucinous intrahepatic cholangiocarcinoma 10.2 KRT7 CDX2
25 ovarian seromucinous carcinoma 10.2 KRT7 CDX2
26 bartholin's gland disease 10.2 KRT7 CDX2
27 female urethral cancer 10.2 KRT7 CDX2
28 jejunal cancer 10.2 KRT7 CDX2
29 jejunal adenocarcinoma 10.2 KRT7 CDX2
30 ovarian cystadenoma 10.2 KRT7 GAST
31 anal canal adenocarcinoma 10.2 KRT7 CDX2
32 appendiceal neoplasm 10.2 KRT7 CDX2
33 peptic esophagitis 10.2 GAST CDX2
34 bile reflux 10.2 GAST CDX2
35 mucinous bronchioloalveolar adenocarcinoma 10.2 KRT7 CDX2
36 glandular cystitis 10.2 KRT7 CDX2
37 ovarian mucinous neoplasm 10.2 KRT7 CDX2
38 linitis plastica 10.2 KRT7 CDX2
39 thymus clear cell carcinoma 10.2 KRT7 CDX2
40 papillary adenocarcinoma 10.2 KRT7 CDX2
41 mucinous stomach adenocarcinoma 10.2 KRT7 CDX2
42 cervical adenoma malignum 10.2 KRT7 CDX2
43 appendix disease 10.2 KRT7 CDX2
44 duodenum adenocarcinoma 10.2 KRT7 CDX2
45 bladder clear cell adenocarcinoma 10.2 KRT7 CDX2
46 cervical neuroblastoma 10.2 VIP SYP
47 clear cell basal cell carcinoma 10.2 KRT7 CDX2
48 bladder adenocarcinoma 10.2 KRT7 CDX2
49 appendix cancer 10.1 KRT7 CDX2
50 esophageal adenosquamous carcinoma 10.1 KRT7 CDX2

Graphical network of the top 20 diseases related to Rectum Neuroendocrine Neoplasm:



Diseases related to Rectum Neuroendocrine Neoplasm

Symptoms & Phenotypes for Rectum Neuroendocrine Neoplasm

Human phenotypes related to Rectum Neuroendocrine Neoplasm:

58 31 (show all 25)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
2 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
3 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
4 constipation 58 31 frequent (33%) Frequent (79-30%) HP:0002019
5 hematochezia 58 31 frequent (33%) Frequent (79-30%) HP:0002573
6 tenesmus 58 31 frequent (33%) Frequent (79-30%) HP:0012702
7 hypoactive bowel sounds 58 31 frequent (33%) Frequent (79-30%) HP:0030144
8 atypical pulmonary carcinoid tumor 58 31 frequent (33%) Frequent (79-30%) HP:0030446
9 hepatomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0002240
10 elevated hepatic transaminase 58 31 occasional (7.5%) Occasional (29-5%) HP:0002910
11 chronic noninfectious lymphadenopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0002730
12 melena 58 31 occasional (7.5%) Occasional (29-5%) HP:0002249
13 hypotension 58 31 very rare (1%) Very rare (<4-1%) HP:0002615
14 tricuspid regurgitation 58 31 very rare (1%) Very rare (<4-1%) HP:0005180
15 facial telangiectasia 58 31 very rare (1%) Very rare (<4-1%) HP:0007380
16 palpitations 58 31 very rare (1%) Very rare (<4-1%) HP:0001962
17 right ventricular failure 58 31 very rare (1%) Very rare (<4-1%) HP:0001708
18 lack of bowel sounds 58 31 very rare (1%) Very rare (<4-1%) HP:0030145
19 increased serum serotonin 58 31 very rare (1%) Very rare (<4-1%) HP:0003144
20 bronchospasm 58 31 very rare (1%) Very rare (<4-1%) HP:0025428
21 protracted diarrhea 58 31 very rare (1%) Very rare (<4-1%) HP:0004385
22 bowel urgency 58 31 very rare (1%) Very rare (<4-1%) HP:0012701
23 abnormal pulmonary valve cusp morphology 58 31 very rare (1%) Very rare (<4-1%) HP:0031566
24 carcinoid tumor 58 Obligate (100%)
25 bloody diarrhea 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Rectum Neuroendocrine Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.17 AFP CDX2 GAST KRT7 PIK3C2A SST

Drugs & Therapeutics for Rectum Neuroendocrine Neoplasm

Drugs for Rectum Neuroendocrine Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
2 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cap Endoscopic Mucosal Resection(EMR-C) Versus Endoscopic Submucosal Dissection(ESD) for Treatment of Rectal Neuroendocrine Tumor(NET) Less Than 10mm Not yet recruiting NCT03982264

Search NIH Clinical Center for Rectum Neuroendocrine Neoplasm

Genetic Tests for Rectum Neuroendocrine Neoplasm

Anatomical Context for Rectum Neuroendocrine Neoplasm

MalaCards organs/tissues related to Rectum Neuroendocrine Neoplasm:

40
Liver, Lymph Node, Colon, Prostate

Publications for Rectum Neuroendocrine Neoplasm

Articles related to Rectum Neuroendocrine Neoplasm:

(show top 50) (show all 69)
# Title Authors PMID Year
1
A rectal neuroendocrine tumor in a patient with Crohn's disease: a case report and literature review. 61
31705376 2020
2
Underwater endoscopic mucosal resection for esophageal granular cell tumor sized more than 1 cm. 61
32512623 2020
3
Cut the weeds and dig up the roots: clip-and-snare assisted endoscopic mucosal resection of a rectal neuroendocrine tumor. 61
32483787 2020
4
Successful further endoscopic mucosal resection with an over-the-scope clip with circumferential mucosal incision for a residual rectal neuroendocrine tumor. 61
31909845 2020
5
Rectal neuroendocrine tumor - Case report. 61
31635854 2020
6
Rectal neuroendocrine tumor developing lateral lymph node metastasis after curative resection: a case report. 61
32284069 2020
7
[Case of a 5mm Rectal Neuroendocrine Tumor(G1)with Lymph Node Metastasis]. 61
32389973 2020
8
Single Rectal Neuroendocrine Tumor Associated with Multiple Endocrine Cell Micronests. 61
31666465 2020
9
Synchronous NET and colorectal cancer development: a case report. 61
31919616 2020
10
Lymphovascular invasion as a prognostic value in small rectal neuroendocrine tumor treated by local excision: A systematic review and meta-analysis. 61
31585816 2019
11
Rectal neuroendocrine tumor presenting as a polyp with hepatic metastases. 61
31375265 2019
12
Endoscopic Resection of a Rectal Neuroendocrine Tumor: Hybrid Endoscopic Submucosal Dissection. 61
30976620 2019
13
Resection of primary tumor may prolong survival in metastatic gastroenteropancreatic neuroendocrine tumors. 61
30366604 2019
14
Long-term outcomes according to additional treatments after endoscopic resection for rectal small neuroendocrine tumors. 61
30894571 2019
15
Difficulty of predicting lymph node metastasis on CT in patients with rectal neuroendocrine tumors. 61
30742649 2019
16
Stereotactic Pelvic Navigation With Augmented Reality for Transanal Total Mesorectal Excision. 61
30531268 2019
17
Intratumoral Hemorrhage of Liver Metastasis from a Rectal Neuroendocrine Tumor. 61
30210114 2019
18
[Transanal Minimally Invasive Surgery for Rectal Neuroendocrine Tumor]. 61
30692455 2018
19
[A Small Rectal Neuroendocrine Tumor of Less Than 5mm with Lymph Node Metastasis]. 61
30692419 2018
20
Endoscopic submucosal resection with an endoscopic variceal ligation device for the treatment of rectal neuroendocrine tumors. 61
30167779 2018
21
A case report of neuroendocrine tumor (G3) at lower rectum with liver metastasis. 61
30235718 2018
22
[Endoscopic Treatment Outcome of Rectal Neuroendocrine Tumors Removed by Ligation-assisted Endoscopic Submucosal Resection]. 61
30270594 2018
23
Rectal Carcinoid Tumor With Liver Metastases Treated by Local Excision and Orthotopic Liver Transplant With Long-term Follow-up. 61
28350289 2018
24
Acute Pancreatitis Following Peptide Receptor Radionuclide Therapy: An Unusual Adverse Event. 61
29762236 2018
25
Rectal Neuroendocrine Tumor with Synchronous Pancreatic Metastasis: A Case Report. 61
29961930 2018
26
Clinical outcomes of endoscopic mucosal resection for rectal neuroendocrine tumor. 61
29866049 2018
27
A small, well-differentiated rectal neuroendocrine tumor with multiple lymph node metastases: A case report. 61
29725436 2018
28
Rectal neuroendocrine tumor as an incidental finding in the doughnut of rectal adenocarcinoma resection specimen. What would have happened if we had not examined the doughnut? 61
29169613 2018
29
Tumor Cystic Necrosis Following Peptide Receptor Radionuclide Therapy in Neuroendocrine Tumors. 61
29356741 2018
30
A 10-year History of a Diminutive Rectal Neuroendocrine Tumor. 61
29151521 2018
31
Expanding the Spectrum of Colonic Manifestations in Tuberous Sclerosis: L-Cell Neuroendocrine Tumor Arising in the Background of Rectal PEComa. 61
28733877 2018
32
Underwater endoscopic mucosal resection: a new endoscopic method for resection of rectal neuroendocrine tumor grade 1 (carcinoid) ≤ 10 mm in diameter. 61
29344571 2018
33
Local resection of rectal neuroendocrine tumor with first clinical manifestation of giant liver metastasis by transanal endoscopic microsurgery: A case report. 61
29390320 2017
34
A rare association of celiac disease and rectal neuroendocrine tumor. 61
28755101 2017
35
Evaluation of treatment for rectal neuroendocrine tumors sized under 20 mm in comparison with the WHO 2010 guidelines. 61
28894583 2017
36
[Standardized development of transanal endoscopic microsurgery]. 61
28836241 2017
37
Rectal neuroendocrine tumor with an exceptional behaviour. 61
27129890 2017
38
Endoscopic Submucosal Dissection of a Rectal Neuroendocrine Tumor Using Linked Color Imaging Technique. 61
28469111 2017
39
Is endoscopic ultrasonography essential for endoscopic resection of small rectal neuroendocrine tumors? 61
28373770 2017
40
Recurrence 30 Years after Surgical Resection of a Localized Rectal Neuroendocrine Tumor. 61
28626177 2017
41
Rectal Neuroendocrine Tumor G1 with a Solitary Hepatic Metastatic Lesion. 61
28154272 2017
42
Evaluation of the risk factors associated with rectal neuroendocrine tumors: a big data analytic study from a health screening center. 61
27025841 2016
43
Enhanced detection of lymphovascular invasion in small rectal neuroendocrine tumors using D2-40 and Elastica van Gieson immunohistochemical analysis. 61
27748061 2016
44
[A Rare Complication of Transcatheter Arterial Injection for Multiple Liver Metastases of Rectal Neuroendocrine Tumor - A Case Report]. 61
28133133 2016
45
[Multiple Metachronal Liver Metastases from a Rectal Neuroendocrine Tumor Controlled by Repeated Transcatheter Arterial Chemoembolization]. 61
28133140 2016
46
Two Cases of Rectal Neuroendocrine Tumor Resection Combined with Dissection of the Circular Muscle Layer Using the Endoscopic Submucosal Dissection Technique. 61
27990103 2016
47
A case of rectal carcinoid, 7 mm in diameter, with skip metastasis to the lateral lymph node. 61
27073660 2016
48
Central calcification in a rectal neuroendocrine tumor. 61
26620884 2016
49
Rectal neuroendocrine tumor with uncommon metastatic spread: A case report and review of literature. 61
26909138 2016
50
"Underwater" endoscopic submucosal dissection: a novel technique for complete resection of a rectal neuroendocrine tumor. 61
26890547 2016

Variations for Rectum Neuroendocrine Neoplasm

Expression for Rectum Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Rectum Neuroendocrine Neoplasm.

Pathways for Rectum Neuroendocrine Neoplasm

Pathways related to Rectum Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.47 VIP GAST

GO Terms for Rectum Neuroendocrine Neoplasm

Molecular functions related to Rectum Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 VIP SST GAST

Sources for Rectum Neuroendocrine Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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