MCID: RCT013
MIFTS: 28

Rectum Signet Ring Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Rectum Signet Ring Adenocarcinoma

MalaCards integrated aliases for Rectum Signet Ring Adenocarcinoma:

Name: Rectum Signet Ring Adenocarcinoma 12 15
Signet Ring Cell Adenocarcinoma of Rectum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7707
NCIt 49 C9168
UMLS 71 C0279654

Summaries for Rectum Signet Ring Adenocarcinoma

MalaCards based summary : Rectum Signet Ring Adenocarcinoma, also known as signet ring cell adenocarcinoma of rectum, is related to signet ring cell adenocarcinoma and adenocarcinoma. An important gene associated with Rectum Signet Ring Adenocarcinoma is PMS1 (PMS1 Homolog 1, Mismatch Repair System Component), and among its related pathways/superpathways are Direct p53 effectors and Platinum drug resistance. The drugs Pancrelipase and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and ovary, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and neoplasm

Related Diseases for Rectum Signet Ring Adenocarcinoma

Diseases related to Rectum Signet Ring Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 signet ring cell adenocarcinoma 29.8 MSH2 MLH1 CEACAM5
2 adenocarcinoma 29.6 MSH2 MLH1 CEACAM5
3 liver lipoma 10.2 CEACAM5 AFP
4 malignant sertoli-leydig cell tumor 10.2 CEACAM5 AFP
5 urachal adenocarcinoma 10.2 CEACAM5 AFP
6 gestational ovarian choriocarcinoma 10.2 CEACAM5 AFP
7 immature teratoma of ovary 10.2 CEACAM5 AFP
8 mature teratoma 10.2 CEACAM5 AFP
9 ovarian mixed germ cell neoplasm 10.2 CEACAM5 AFP
10 renal pelvis adenocarcinoma 10.2 CEACAM5 AFP
11 bile duct cystadenocarcinoma 10.2 CEACAM5 AFP
12 colonic lymphangioma 10.2 CEACAM5 AFP
13 liver lymphoma 10.2 CEACAM5 AFP
14 adult teratoma 10.2 CEACAM5 AFP
15 liver sarcoma 10.2 CEACAM5 AFP
16 benign mesothelioma 10.2 CEACAM5 AFP
17 sarcomatous intrahepatic cholangiocarcinoma 10.2 CEACAM5 AFP
18 mediastinal cancer 10.2 CEACAM5 AFP
19 bile duct cysts 10.2 CEACAM5 AFP
20 ovarian benign neoplasm 10.2 CEACAM5 AFP
21 ovarian germ cell cancer 10.2 CEACAM5 AFP
22 jejunal adenocarcinoma 10.1 MLH1 CEACAM5
23 malignant teratoma 10.1 CEACAM5 AFP
24 transverse colon cancer 10.1 MLH1 CEACAM5
25 benign teratoma 10.1 CEACAM5 AFP
26 klatskin's tumor 10.1 CEACAM5 AFP
27 pineoblastoma 10.1 CEACAM5 AFP
28 sex cord-gonadal stromal tumor 10.1 CEACAM5 AFP
29 colon leiomyosarcoma 10.1 CEACAM5 APOLD1
30 spindle cell intraocular melanoma 10.1 PMS2 MLH1
31 mixed cell type cancer 10.1 CEACAM5 AFP
32 rectosigmoid junction neoplasm 10.1 CEACAM5 APOLD1
33 sigmoid neoplasm 10.1 CEACAM5 APOLD1
34 cystic teratoma 10.1 CEACAM5 AFP
35 tubular adenocarcinoma 10.1 CEACAM5 AFP
36 linitis plastica 10.1 CEACAM5 APOLD1
37 microinvasive gastric cancer 10.0 MLH1 CEACAM5
38 ovarian squamous cell carcinoma 10.0 CEACAM5 APOLD1
39 large intestine lipoma 10.0 CEACAM5 APOLD1
40 colon sarcoma 10.0 CEACAM5 APOLD1
41 lipoma of colon 10.0 CEACAM5 APOLD1
42 rectosigmoid cancer 10.0 CEACAM5 APOLD1
43 benign mesenchymoma 10.0 APOLD1 AFP
44 hemorrhoid 10.0 CEACAM5 APOLD1
45 anus cancer 10.0 CEACAM5 APOLD1
46 cystadenoma 10.0 CEACAM5 AFP
47 germinoma 10.0 PMS2 AFP
48 fallopian tube endometrioid adenocarcinoma 10.0 PMS2 APOLD1
49 poliomyelitis 9.9 APOLD1 AFP
50 rectal disease 9.9 CEACAM5 APOLD1

Graphical network of the top 20 diseases related to Rectum Signet Ring Adenocarcinoma:



Diseases related to Rectum Signet Ring Adenocarcinoma

Symptoms & Phenotypes for Rectum Signet Ring Adenocarcinoma

GenomeRNAi Phenotypes related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.92 MLH1 MSH2 PMS1 PMS2

MGI Mouse Phenotypes related to Rectum Signet Ring Adenocarcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 AFP MLH1 MSH2 PMS1 PMS2

Drugs & Therapeutics for Rectum Signet Ring Adenocarcinoma

Drugs for Rectum Signet Ring Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 1 53608-75-6
2 Liver Extracts Phase 1
3 pancreatin Phase 1
4 Immunoglobulins Phase 1
5 Antibodies Phase 1
6 Cola Phase 1
7 Gastrointestinal Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Study of T Cells Modified With Chimeric AntiCEA Immunoglobulin-T Cell Receptors (IgTCR) in Adenocarcinoma Completed NCT00004178 Phase 1

Search NIH Clinical Center for Rectum Signet Ring Adenocarcinoma

Genetic Tests for Rectum Signet Ring Adenocarcinoma

Anatomical Context for Rectum Signet Ring Adenocarcinoma

MalaCards organs/tissues related to Rectum Signet Ring Adenocarcinoma:

40
Colon, Liver, Ovary, T Cells, Breast, Small Intestine, Skin

Publications for Rectum Signet Ring Adenocarcinoma

Articles related to Rectum Signet Ring Adenocarcinoma:

# Title Authors PMID Year
1
Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review. 61
22429319 2013
2
Signet-ring cell adenocarcinoma of rectum: a histological, histochemical and electron microscopic study. 61
6284632 1982

Variations for Rectum Signet Ring Adenocarcinoma

Expression for Rectum Signet Ring Adenocarcinoma

Search GEO for disease gene expression data for Rectum Signet Ring Adenocarcinoma.

Pathways for Rectum Signet Ring Adenocarcinoma

GO Terms for Rectum Signet Ring Adenocarcinoma

Cellular components related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 9.13 PMS2 PMS1 MLH1
2 mismatch repair complex GO:0032300 8.92 PMS2 PMS1 MSH2 MLH1

Biological processes related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.73 PMS2 PMS1 MSH2 MLH1
2 DNA repair GO:0006281 9.67 PMS2 PMS1 MSH2 MLH1
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.48 MSH2 MLH1
4 isotype switching GO:0045190 9.46 MSH2 MLH1
5 positive regulation of isotype switching to IgG isotypes GO:0048304 9.4 MSH2 MLH1
6 positive regulation of isotype switching to IgA isotypes GO:0048298 9.32 MSH2 MLH1
7 somatic recombination of immunoglobulin gene segments GO:0016447 9.26 MSH2 MLH1
8 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.16 MSH2 MLH1
9 somatic hypermutation of immunoglobulin genes GO:0016446 9.13 PMS2 MSH2 MLH1
10 mismatch repair GO:0006298 8.92 PMS2 PMS1 MSH2 MLH1

Molecular functions related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.54 PMS1 MSH2 MLH1
2 single-stranded DNA binding GO:0003697 9.5 PMS2 MSH2 MLH1
3 MutSalpha complex binding GO:0032407 9.26 PMS2 MLH1
4 ATPase activity GO:0016887 9.26 PMS2 PMS1 MSH2 MLH1
5 guanine/thymine mispair binding GO:0032137 9.16 MSH2 MLH1
6 mismatched DNA binding GO:0030983 8.92 PMS2 PMS1 MSH2 MLH1

Sources for Rectum Signet Ring Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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