Rectum Signet Ring Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Rectum Signet Ring Adenocarcinoma

MalaCards integrated aliases for Rectum Signet Ring Adenocarcinoma:

Name: Rectum Signet Ring Adenocarcinoma ¹² ¹⁵

Signet Ring Cell Adenocarcinoma of Rectum ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7707

NCIt ⁴⁹ C9168

UMLS ⁷¹ C0279654

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Summaries for Rectum Signet Ring Adenocarcinoma

MalaCards based summary : Rectum Signet Ring Adenocarcinoma, also known as signet ring cell adenocarcinoma of rectum, is related to signet ring cell adenocarcinoma and liver lipoma. An important gene associated with Rectum Signet Ring Adenocarcinoma is PMS1 (PMS1 Homolog 1, Mismatch Repair System Component), and among its related pathways/superpathways are Direct p53 effectors and Platinum drug resistance. The drugs Pancrelipase and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include t cells, liver and breast, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Rectum Signet Ring Adenocarcinoma

Diseases related to Rectum Signet Ring Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)

#	Related Disease	Score	Top Affiliating Genes
1	signet ring cell adenocarcinoma	29.8	MSH2 MLH1 CEACAM5
2	liver lipoma	10.2	CEACAM5 AFP
3	urachal adenocarcinoma	10.2	CEACAM5 AFP
4	gestational ovarian choriocarcinoma	10.2	CEACAM5 AFP
5	renal pelvis adenocarcinoma	10.2	CEACAM5 AFP
6	immature teratoma of ovary	10.2	CEACAM5 AFP
7	mature teratoma	10.2	CEACAM5 AFP
8	papillary thymic adenocarcinoma	10.2	CEACAM5 AFP
9	bile duct cystadenocarcinoma	10.2	CEACAM5 AFP
10	liver leiomyoma	10.2	CEACAM5 AFP
11	adult teratoma	10.2	CEACAM5 AFP
12	colonic lymphangioma	10.2	CEACAM5 AFP
13	mature teratoma of the ovary	10.2	CEACAM5 AFP
14	ovarian mixed germ cell neoplasm	10.2	CEACAM5 AFP
15	liver sarcoma	10.2	CEACAM5 AFP
16	benign mesothelioma	10.2	CEACAM5 AFP
17	paratesticular lipoma	10.2	CEACAM5 AFP
18	lipoma of spermatic cord	10.2	CEACAM5 AFP
19	biliary tract benign neoplasm	10.2	CEACAM5 AFP
20	sarcomatous intrahepatic cholangiocarcinoma	10.2	CEACAM5 AFP
21	large intestine lipoma	10.2	CEACAM5 APOLD1
22	lipoma of colon	10.2	CEACAM5 APOLD1
23	bile duct cysts	10.1	CEACAM5 AFP
24	mediastinal cancer	10.1	CEACAM5 AFP
25	ovarian benign neoplasm	10.1	CEACAM5 AFP
26	ovarian germ cell cancer	10.1	CEACAM5 AFP
27	rectosigmoid junction neoplasm	10.1	CEACAM5 APOLD1
28	sigmoid neoplasm	10.1	CEACAM5 APOLD1
29	descending colon cancer	10.1	CEACAM5 APOLD1
30	colon leiomyosarcoma	10.1	CEACAM5 APOLD1
31	hepatoid adenocarcinoma	10.1	CEACAM5 AFP
32	malignant teratoma	10.1	CEACAM5 AFP
33	klatskin's tumor	10.1	CEACAM5 AFP
34	pineoblastoma	10.1	CEACAM5 AFP
35	sex cord-gonadal stromal tumor	10.1	CEACAM5 AFP
36	endodermal sinus tumor	10.1	CEACAM5 AFP
37	mixed cell type cancer	10.1	CEACAM5 AFP
38	cystic teratoma	10.1	CEACAM5 AFP
39	tubular adenocarcinoma	10.1	CEACAM5 AFP
40	paralytic poliomyelitis	10.1	APOLD1 AFP
41	poliomyelitis	10.1	APOLD1 AFP
42	hemorrhoid	10.1	CEACAM5 APOLD1
43	reproductive organ benign neoplasm	10.1	CEACAM5 AFP
44	benign teratoma	10.0	CEACAM5 AFP
45	esophageal tuberculosis	10.0	PMS2 CEACAM5
46	anus disease	10.0	CEACAM5 APOLD1
47	spindle cell intraocular melanoma	10.0	PMS2 MLH1
48	cystadenoma	10.0	CEACAM5 AFP
49	anal squamous cell carcinoma	10.0	MLH1 APOLD1
50	rectal disease	10.0	CEACAM5 APOLD1

Graphical network of the top 20 diseases related to Rectum Signet Ring Adenocarcinoma:

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Symptoms & Phenotypes for Rectum Signet Ring Adenocarcinoma

GenomeRNAi Phenotypes related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.1	MLH1
2	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.1	MLH1
3	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-3	9.1	MLH1 MSH2 PMS1 PMS2

MGI Mouse Phenotypes related to Rectum Signet Ring Adenocarcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.02	AFP MLH1 MSH2 PMS1 PMS2

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Drugs & Therapeutics for Rectum Signet Ring Adenocarcinoma

Drugs for Rectum Signet Ring Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Pancrelipase

Approved, Investigational

Phase 1

53608-75-6

2

Immunoglobulins

Phase 1

3

Antibodies

Phase 1

4

Cola

Phase 1

5

Immunoglobulins, Intravenous

Phase 1

6

Liver Extracts

Phase 1

7

pancreatin

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase I Study of T Cells Modified With Chimeric AntiCEA Immunoglobulin-T Cell Receptors (IgTCR) in Adenocarcinoma	Completed	NCT00004178	Phase 1

Search NIH Clinical Center for Rectum Signet Ring Adenocarcinoma

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Genetic Tests for Rectum Signet Ring Adenocarcinoma

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Anatomical Context for Rectum Signet Ring Adenocarcinoma

MalaCards organs/tissues related to Rectum Signet Ring Adenocarcinoma:

⁴⁰

T Cells, Liver, Breast

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Publications for Rectum Signet Ring Adenocarcinoma

Articles related to Rectum Signet Ring Adenocarcinoma:

#	Title	Authors	PMID	Year
1	Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review. ⁶¹	Shaaban H...Francis I	22429319	2013
2	Signet-ring cell adenocarcinoma of rectum: a histological, histochemical and electron microscopic study. ⁶¹	Shousha S	6284632	1982

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Genes for Rectum Signet Ring Adenocarcinoma

Genes related to Rectum Signet Ring Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PMS1	PMS1 Homolog 1, Mismatch Repair System Component	Protein Coding	5.06	DISEASES inferred ¹⁵
2	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	4.87	DISEASES inferred ¹⁵
3	AFP	Alpha Fetoprotein	Protein Coding	4.69	DISEASES inferred ¹⁵
4	APOLD1	Apolipoprotein L Domain Containing 1	Protein Coding	4.33	DISEASES inferred ¹⁵
5	PMS2	PMS1 Homolog 2, Mismatch Repair System Component	Protein Coding	4.3	DISEASES inferred ¹⁵
6	MSH2	MutS Homolog 2	Protein Coding	4.03	DISEASES inferred ¹⁵
7	MLH1	MutL Homolog 1	Protein Coding	3.89	DISEASES inferred ¹⁵

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Variations for Rectum Signet Ring Adenocarcinoma

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Expression for Rectum Signet Ring Adenocarcinoma

Search GEO for disease gene expression data for Rectum Signet Ring Adenocarcinoma.

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Pathways for Rectum Signet Ring Adenocarcinoma

Pathways related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Direct p53 effectors ¹	11.38	PMS2 MSH2 MLH1 AFP
2	Platinum drug resistance ³⁶	11.23	MSH2 MLH1
3	Busulfan Pathway, Pharmacodynamics ⁶⁰ Show member pathways Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) ¹ FMO oxidises nucleophiles ⁶⁵	10.97	MSH2 MLH1
4	Mismatch repair ¹ ³⁶ ⁶⁵ Show member pathways Mismatch repair (MMR) directed by MSH2-MSH3 (MutSbeta) ⁶⁵ Mismatch repair (MMR) directed by MSH2-MSH6 (MutSalpha) ⁶⁵ Mismatch Repair in Eukaryotes ⁶³	10.9	PMS2 PMS1 MSH2 MLH1
5	Doxorubicin Pathway, Pharmacokinetics ⁶⁰ Show member pathways Doxorubicin Pathway (Cancer Cell), Pharmacodynamics ⁶⁰	10.86	MSH2 MLH1
6	Platinum Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.79	PMS2 MSH2 MLH1

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GO Terms for Rectum Signet Ring Adenocarcinoma

Cellular components related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	MutLalpha complex	GO:0032389	9.13	PMS2 PMS1 MLH1
2	mismatch repair complex	GO:0032300	8.92	PMS2 PMS1 MSH2 MLH1

Biological processes related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to DNA damage stimulus	GO:0006974	9.73	PMS2 PMS1 MSH2 MLH1
2	DNA repair	GO:0006281	9.67	PMS2 PMS1 MSH2 MLH1
3	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.48	MSH2 MLH1
4	isotype switching	GO:0045190	9.46	MSH2 MLH1
5	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.4	MSH2 MLH1
6	positive regulation of isotype switching to IgA isotypes	GO:0048298	9.32	MSH2 MLH1
7	somatic recombination of immunoglobulin gene segments	GO:0016447	9.26	MSH2 MLH1
8	somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	9.16	MSH2 MLH1
9	somatic hypermutation of immunoglobulin genes	GO:0016446	9.13	PMS2 MSH2 MLH1
10	mismatch repair	GO:0006298	8.92	PMS2 PMS1 MSH2 MLH1

Molecular functions related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:0019899	9.54	PMS1 MSH2 MLH1
2	single-stranded DNA binding	GO:0003697	9.5	PMS2 MSH2 MLH1
3	MutSalpha complex binding	GO:0032407	9.26	PMS2 MLH1
4	ATPase activity	GO:0016887	9.26	PMS2 PMS1 MSH2 MLH1
5	guanine/thymine mispair binding	GO:0032137	9.16	MSH2 MLH1
6	mismatched DNA binding	GO:0030983	8.92	PMS2 PMS1 MSH2 MLH1

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Sources for Rectum Signet Ring Adenocarcinoma

¹ BioSystems

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⁷⁴ Wikipedia