Rectum Signet Ring Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Rectum Signet Ring Adenocarcinoma

MalaCards integrated aliases for Rectum Signet Ring Adenocarcinoma:

Name: Rectum Signet Ring Adenocarcinoma ¹² ¹⁵

Signet Ring Cell Adenocarcinoma of Rectum ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7707

NCIt ⁴⁹ C9168

UMLS ⁷¹ C0279654

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Summaries for Rectum Signet Ring Adenocarcinoma

MalaCards based summary : Rectum Signet Ring Adenocarcinoma, also known as signet ring cell adenocarcinoma of rectum, is related to signet ring cell adenocarcinoma and adenocarcinoma. An important gene associated with Rectum Signet Ring Adenocarcinoma is PMS1 (PMS1 Homolog 1, Mismatch Repair System Component), and among its related pathways/superpathways are Direct p53 effectors and Platinum drug resistance. The drugs Pancrelipase and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and ovary, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and neoplasm

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Related Diseases for Rectum Signet Ring Adenocarcinoma

Diseases related to Rectum Signet Ring Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)

#	Related Disease	Score	Top Affiliating Genes
1	signet ring cell adenocarcinoma	29.8	MSH2 MLH1 CEACAM5
2	adenocarcinoma	29.6	MSH2 MLH1 CEACAM5
3	liver lipoma	10.2	CEACAM5 AFP
4	malignant sertoli-leydig cell tumor	10.2	CEACAM5 AFP
5	urachal adenocarcinoma	10.2	CEACAM5 AFP
6	gestational ovarian choriocarcinoma	10.2	CEACAM5 AFP
7	immature teratoma of ovary	10.2	CEACAM5 AFP
8	mature teratoma	10.2	CEACAM5 AFP
9	ovarian mixed germ cell neoplasm	10.2	CEACAM5 AFP
10	renal pelvis adenocarcinoma	10.2	CEACAM5 AFP
11	bile duct cystadenocarcinoma	10.2	CEACAM5 AFP
12	colonic lymphangioma	10.2	CEACAM5 AFP
13	liver lymphoma	10.2	CEACAM5 AFP
14	adult teratoma	10.2	CEACAM5 AFP
15	liver sarcoma	10.2	CEACAM5 AFP
16	benign mesothelioma	10.2	CEACAM5 AFP
17	sarcomatous intrahepatic cholangiocarcinoma	10.2	CEACAM5 AFP
18	mediastinal cancer	10.2	CEACAM5 AFP
19	bile duct cysts	10.2	CEACAM5 AFP
20	ovarian benign neoplasm	10.2	CEACAM5 AFP
21	ovarian germ cell cancer	10.2	CEACAM5 AFP
22	jejunal adenocarcinoma	10.1	MLH1 CEACAM5
23	malignant teratoma	10.1	CEACAM5 AFP
24	transverse colon cancer	10.1	MLH1 CEACAM5
25	benign teratoma	10.1	CEACAM5 AFP
26	klatskin's tumor	10.1	CEACAM5 AFP
27	pineoblastoma	10.1	CEACAM5 AFP
28	sex cord-gonadal stromal tumor	10.1	CEACAM5 AFP
29	colon leiomyosarcoma	10.1	CEACAM5 APOLD1
30	spindle cell intraocular melanoma	10.1	PMS2 MLH1
31	mixed cell type cancer	10.1	CEACAM5 AFP
32	rectosigmoid junction neoplasm	10.1	CEACAM5 APOLD1
33	sigmoid neoplasm	10.1	CEACAM5 APOLD1
34	cystic teratoma	10.1	CEACAM5 AFP
35	tubular adenocarcinoma	10.1	CEACAM5 AFP
36	linitis plastica	10.1	CEACAM5 APOLD1
37	microinvasive gastric cancer	10.0	MLH1 CEACAM5
38	ovarian squamous cell carcinoma	10.0	CEACAM5 APOLD1
39	large intestine lipoma	10.0	CEACAM5 APOLD1
40	colon sarcoma	10.0	CEACAM5 APOLD1
41	lipoma of colon	10.0	CEACAM5 APOLD1
42	rectosigmoid cancer	10.0	CEACAM5 APOLD1
43	benign mesenchymoma	10.0	APOLD1 AFP
44	hemorrhoid	10.0	CEACAM5 APOLD1
45	anus cancer	10.0	CEACAM5 APOLD1
46	cystadenoma	10.0	CEACAM5 AFP
47	germinoma	10.0	PMS2 AFP
48	fallopian tube endometrioid adenocarcinoma	10.0	PMS2 APOLD1
49	poliomyelitis	9.9	APOLD1 AFP
50	rectal disease	9.9	CEACAM5 APOLD1

Graphical network of the top 20 diseases related to Rectum Signet Ring Adenocarcinoma:

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Symptoms & Phenotypes for Rectum Signet Ring Adenocarcinoma

GenomeRNAi Phenotypes related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-3	8.92	MLH1 MSH2 PMS1 PMS2

MGI Mouse Phenotypes related to Rectum Signet Ring Adenocarcinoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.02	AFP MLH1 MSH2 PMS1 PMS2

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Drugs & Therapeutics for Rectum Signet Ring Adenocarcinoma

Drugs for Rectum Signet Ring Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Pancrelipase

Approved, Investigational

Phase 1

53608-75-6

2

Liver Extracts

Phase 1

3

pancreatin

Phase 1

4

Immunoglobulins

Phase 1

5

Antibodies

Phase 1

6

Cola

Phase 1

7

Gastrointestinal Agents

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase I Study of T Cells Modified With Chimeric AntiCEA Immunoglobulin-T Cell Receptors (IgTCR) in Adenocarcinoma	Completed	NCT00004178	Phase 1

Search NIH Clinical Center for Rectum Signet Ring Adenocarcinoma

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Genetic Tests for Rectum Signet Ring Adenocarcinoma

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Anatomical Context for Rectum Signet Ring Adenocarcinoma

MalaCards organs/tissues related to Rectum Signet Ring Adenocarcinoma:

⁴⁰

Colon, Liver, Ovary, T Cells, Breast, Small Intestine, Skin

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Publications for Rectum Signet Ring Adenocarcinoma

Articles related to Rectum Signet Ring Adenocarcinoma:

#	Title	Authors	PMID	Year
1	Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review. ⁶¹	Shaaban H...Francis I	22429319	2013
2	Signet-ring cell adenocarcinoma of rectum: a histological, histochemical and electron microscopic study. ⁶¹	Shousha S	6284632	1982

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Genes for Rectum Signet Ring Adenocarcinoma

Genes related to Rectum Signet Ring Adenocarcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PMS1	PMS1 Homolog 1, Mismatch Repair System Component	Protein Coding	5.05	DISEASES inferred ¹⁵
2	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	4.84	DISEASES inferred ¹⁵
3	AFP	Alpha Fetoprotein	Protein Coding	4.69	DISEASES inferred ¹⁵
4	PMS2	PMS1 Homolog 2, Mismatch Repair System Component	Protein Coding	4.31	DISEASES inferred ¹⁵
5	APOLD1	Apolipoprotein L Domain Containing 1	Protein Coding	4.3	DISEASES inferred ¹⁵
6	MSH2	MutS Homolog 2	Protein Coding	4.02	DISEASES inferred ¹⁵
7	MLH1	MutL Homolog 1	Protein Coding	3.87	DISEASES inferred ¹⁵

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Variations for Rectum Signet Ring Adenocarcinoma

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Expression for Rectum Signet Ring Adenocarcinoma

Search GEO for disease gene expression data for Rectum Signet Ring Adenocarcinoma.

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Pathways for Rectum Signet Ring Adenocarcinoma

Pathways related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Direct p53 effectors ¹	11.38	PMS2 MSH2 MLH1 AFP
2	Platinum drug resistance ³⁶	11.23	MSH2 MLH1
3	Busulfan Pathway, Pharmacodynamics ⁶⁰ Show member pathways Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) ¹ FMO oxidises nucleophiles ⁶⁵	10.97	MSH2 MLH1
4	Mismatch repair ⁶⁵ ¹ ³⁶ Show member pathways Mismatch repair (MMR) directed by MSH2-MSH3 (MutSbeta) ⁶⁵ Mismatch repair (MMR) directed by MSH2-MSH6 (MutSalpha) ⁶⁵ Mismatch Repair in Eukaryotes ⁶³	10.9	PMS2 PMS1 MSH2 MLH1
5	Doxorubicin Pathway, Pharmacokinetics ⁶⁰ Show member pathways Doxorubicin Pathway (Cancer Cell), Pharmacodynamics ⁶⁰	10.86	MSH2 MLH1
6	Platinum Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	10.79	PMS2 MSH2 MLH1

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GO Terms for Rectum Signet Ring Adenocarcinoma

Cellular components related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	MutLalpha complex	GO:0032389	9.13	PMS2 PMS1 MLH1
2	mismatch repair complex	GO:0032300	8.92	PMS2 PMS1 MSH2 MLH1

Biological processes related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to DNA damage stimulus	GO:0006974	9.73	PMS2 PMS1 MSH2 MLH1
2	DNA repair	GO:0006281	9.67	PMS2 PMS1 MSH2 MLH1
3	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.48	MSH2 MLH1
4	isotype switching	GO:0045190	9.46	MSH2 MLH1
5	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.4	MSH2 MLH1
6	positive regulation of isotype switching to IgA isotypes	GO:0048298	9.32	MSH2 MLH1
7	somatic recombination of immunoglobulin gene segments	GO:0016447	9.26	MSH2 MLH1
8	somatic recombination of immunoglobulin genes involved in immune response	GO:0002204	9.16	MSH2 MLH1
9	somatic hypermutation of immunoglobulin genes	GO:0016446	9.13	PMS2 MSH2 MLH1
10	mismatch repair	GO:0006298	8.92	PMS2 PMS1 MSH2 MLH1

Molecular functions related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:0019899	9.54	PMS1 MSH2 MLH1
2	single-stranded DNA binding	GO:0003697	9.5	PMS2 MSH2 MLH1
3	MutSalpha complex binding	GO:0032407	9.26	PMS2 MLH1
4	ATPase activity	GO:0016887	9.26	PMS2 PMS1 MSH2 MLH1
5	guanine/thymine mispair binding	GO:0032137	9.16	MSH2 MLH1
6	mismatched DNA binding	GO:0030983	8.92	PMS2 PMS1 MSH2 MLH1

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Sources for Rectum Signet Ring Adenocarcinoma

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⁷⁴ Wikipedia