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MCID: RCT013
MIFTS: 24

Rectum Signet Ring Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases
Genes Related diseases Publications Pathways
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Aliases & Classifications for Rectum Signet Ring Adenocarcinoma

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MalaCards integrated aliases for Rectum Signet Ring Adenocarcinoma:

Name: Rectum Signet Ring Adenocarcinoma 12 15
Signet Ring Cell Adenocarcinoma of Rectum 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7707
NCIt 50 C9168
UMLS 71 C0279654
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Summaries for Rectum Signet Ring Adenocarcinoma

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MalaCards based summary : Rectum Signet Ring Adenocarcinoma, also known as signet ring cell adenocarcinoma of rectum, is related to signet ring cell adenocarcinoma and larynx sarcoma. An important gene associated with Rectum Signet Ring Adenocarcinoma is EPCAM (Epithelial Cell Adhesion Molecule), and among its related pathways/superpathways are Direct p53 effectors and Platinum drug resistance. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Rectum Signet Ring Adenocarcinoma

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Diseases related to Rectum Signet Ring Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 signet ring cell adenocarcinoma 30.1 MSH2 MLH1 CEACAM5
2 larynx sarcoma 10.2 EPCAM CEACAM5
3 squamous papillomatosis 10.2 EPCAM CEACAM5
4 benign peritoneal mesothelioma 10.1 EPCAM CEACAM5
5 peritoneum cancer 10.1 EPCAM CEACAM5
6 liver lipoma 10.1 CEACAM5 AFP
7 gestational ovarian choriocarcinoma 10.1 CEACAM5 AFP
8 immature teratoma of ovary 10.1 CEACAM5 AFP
9 mature teratoma 10.1 CEACAM5 AFP
10 urachal adenocarcinoma 10.1 CEACAM5 AFP
11 liver inflammatory pseudotumor 10.1 CEACAM5 AFP
12 adult teratoma 10.1 CEACAM5 AFP
13 dermoid cyst of ovary 10.1 CEACAM5 AFP
14 renal pelvis adenocarcinoma 10.1 CEACAM5 AFP
15 bile duct cystadenocarcinoma 10.1 CEACAM5 AFP
16 colonic lymphangioma 10.1 CEACAM5 AFP
17 lymphangioma 10.1 MLH1 CEACAM5
18 paratesticular lipoma 10.1 CEACAM5 AFP
19 lipoma of spermatic cord 10.1 CEACAM5 AFP
20 liver leiomyoma 10.1 CEACAM5 AFP
21 esophageal adenoid cystic carcinoma 10.1 CEACAM5 AFP
22 ovarian mixed germ cell neoplasm 10.1 CEACAM5 AFP
23 liver sarcoma 10.1 CEACAM5 AFP
24 biliary tract benign neoplasm 10.1 CEACAM5 AFP
25 sarcomatous intrahepatic cholangiocarcinoma 10.1 CEACAM5 AFP
26 common bile duct disease 10.1 CEACAM5 AFP
27 abdominal tuberculosis 10.1 CEACAM5 AFP
28 bile duct cysts 10.1 CEACAM5 AFP
29 ovarian benign neoplasm 10.1 CEACAM5 AFP
30 ovarian germ cell cancer 10.1 CEACAM5 AFP
31 intrahepatic bile duct adenoma 10.0 CEACAM5 AFP
32 klatskin's tumor 10.0 CEACAM5 AFP
33 malignant teratoma 10.0 CEACAM5 AFP
34 seminal vesicle adenocarcinoma 10.0 CEACAM5 AFP
35 gastrointestinal carcinoma 10.0 EPCAM CEACAM5
36 hepatic tuberculosis 10.0 CEACAM5 AFP
37 pineoblastoma 10.0 CEACAM5 AFP
38 villous adenoma 10.0 MLH1 CEACAM5
39 esophageal tuberculosis 10.0 PMS2 CEACAM5
40 spindle cell intraocular melanoma 10.0 PMS2 MLH1
41 mixed cell type cancer 10.0 CEACAM5 AFP
42 sex cord-gonadal stromal tumor 10.0 CEACAM5 AFP
43 tubular adenocarcinoma 10.0 CEACAM5 AFP
44 jejunal adenocarcinoma 10.0 PMS2 MLH1
45 reproductive organ benign neoplasm 10.0 CEACAM5 AFP
46 benign teratoma 10.0 CEACAM5 AFP
47 rectosigmoid cancer 10.0 PMS2 CEACAM5
48 endodermal sinus tumor 10.0 CEACAM5 AFP
49 cystadenoma 9.9 CEACAM5 AFP
50 mucinous adenocarcinoma 9.9 MLH1 CEACAM5

Graphical network of the top 20 diseases related to Rectum Signet Ring Adenocarcinoma:



Diseases related to Rectum Signet Ring Adenocarcinoma
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Symptoms & Phenotypes for Rectum Signet Ring Adenocarcinoma

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GenomeRNAi Phenotypes related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.96 MSH2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.96 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.96 MSH2 PMS2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.96 MSH2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.96 EPCAM
6 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.96 EPCAM
7 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.96 MSH2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.96 PMS2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.96 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.96 PMS2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.96 PMS2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.96 MSH2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.96 EPCAM
14 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.96 AFP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.96 PMS2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-53 9.96 MSH2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-58 9.96 EPCAM
18 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.96 EPCAM
19 Increased shRNA abundance (Z-score > 2) GR00366-A-89 9.96 AFP
20 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.1 MLH1
21 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.1 MLH1
22 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.1 MLH1 MSH2 PMS1 PMS2

MGI Mouse Phenotypes related to Rectum Signet Ring Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 AFP MLH1 MSH2 PMS1 PMS2
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Drugs & Therapeutics for Rectum Signet Ring Adenocarcinoma

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Search Clinical Trials , NIH Clinical Center for Rectum Signet Ring Adenocarcinoma

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Genetic Tests for Rectum Signet Ring Adenocarcinoma

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Anatomical Context for Rectum Signet Ring Adenocarcinoma

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Publications for Rectum Signet Ring Adenocarcinoma

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Articles related to Rectum Signet Ring Adenocarcinoma:

# Title Authors PMID Year
1
Outcomes of Definitive Treatment of Signet Ring Cell Carcinoma of the Rectum: Is Minimal Invasive Surgery Detrimental in Signet Ring Rectal Cancers? 61
33299278 2020
2
Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review. 61
22429319 2013
3
Signet-ring cell adenocarcinoma of rectum: a histological, histochemical and electron microscopic study. 61
6284632 1982
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Variations for Rectum Signet Ring Adenocarcinoma

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Expression for Rectum Signet Ring Adenocarcinoma

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Search GEO for disease gene expression data for Rectum Signet Ring Adenocarcinoma.
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Pathways for Rectum Signet Ring Adenocarcinoma

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Pathways related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Direct p53 effectors 1
11.38 PMS2 MSH2 MLH1 AFP
2
Platinum drug resistance 36
11.23 MSH2 MLH1
3
Busulfan Pathway, Pharmacodynamics 60
Show member pathways
 10.97 MSH2 MLH1
4
Mismatch repair 36 65 1
Show member pathways
 10.9 PMS2 PMS1 MSH2 MLH1
5
Doxorubicin Pathway, Pharmacokinetics 60
Show member pathways
 10.86 MSH2 MLH1
6
Platinum Pathway, Pharmacokinetics/Pharmacodynamics 60
10.79 PMS2 MSH2 MLH1
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GO Terms for Rectum Signet Ring Adenocarcinoma

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Cellular components related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutLalpha complex GO:0032389 8.96 PMS2 MLH1
2 mismatch repair complex GO:0032300 8.92 PMS2 PMS1 MSH2 MLH1

Biological processes related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.73 PMS2 PMS1 MSH2 MLH1
2 DNA repair GO:0006281 9.67 PMS2 PMS1 MSH2 MLH1
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.48 MSH2 MLH1
4 isotype switching GO:0045190 9.46 MSH2 MLH1
5 positive regulation of isotype switching to IgG isotypes GO:0048304 9.4 MSH2 MLH1
6 positive regulation of isotype switching to IgA isotypes GO:0048298 9.32 MSH2 MLH1
7 somatic recombination of immunoglobulin gene segments GO:0016447 9.26 MSH2 MLH1
8 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.16 MSH2 MLH1
9 somatic hypermutation of immunoglobulin genes GO:0016446 9.13 PMS2 MSH2 MLH1
10 mismatch repair GO:0006298 8.92 PMS2 PMS1 MSH2 MLH1

Molecular functions related to Rectum Signet Ring Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.54 PMS1 MSH2 MLH1
2 single-stranded DNA binding GO:0003697 9.5 PMS2 MSH2 MLH1
3 MutSalpha complex binding GO:0032407 9.26 PMS2 MLH1
4 ATPase activity GO:0016887 9.26 PMS2 PMS1 MSH2 MLH1
5 guanine/thymine mispair binding GO:0032137 9.16 MSH2 MLH1
6 mismatched DNA binding GO:0030983 8.92 PMS2 PMS1 MSH2 MLH1
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Sources for Rectum Signet Ring Adenocarcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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