MCID: RCT013
MIFTS: 17

Rectum Signet Ring Adenocarcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Rectum Signet Ring Adenocarcinoma

MalaCards integrated aliases for Rectum Signet Ring Adenocarcinoma:

Name: Rectum Signet Ring Adenocarcinoma 12
Signet Ring Cell Adenocarcinoma of Rectum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7707
NCIt 51 C9168
UMLS 74 C0279654

Summaries for Rectum Signet Ring Adenocarcinoma

MalaCards based summary : Rectum Signet Ring Adenocarcinoma, also known as signet ring cell adenocarcinoma of rectum, is related to adenocarcinoma and signet ring cell adenocarcinoma. The drugs leucovorin and Irinotecan have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and endothelial.

Related Diseases for Rectum Signet Ring Adenocarcinoma

Diseases related to Rectum Signet Ring Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 10.3
2 signet ring cell adenocarcinoma 10.3

Symptoms & Phenotypes for Rectum Signet Ring Adenocarcinoma

Drugs & Therapeutics for Rectum Signet Ring Adenocarcinoma

Drugs for Rectum Signet Ring Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 3,Phase 2,Phase 1 58-05-9 143 6006
2
Irinotecan Approved, Investigational Phase 3,Phase 2,Phase 1 100286-90-6, 97682-44-5 60838
3
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
4
Levoleucovorin Approved, Investigational Phase 3,Phase 2,Phase 1 68538-85-2
5
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 43805 6857599 5310940 9887054
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
7
Calcium Approved, Nutraceutical Phase 3,Phase 2,Phase 1,Early Phase 1 7440-70-2 271
8
Camptothecin Experimental Phase 3 7689-03-4
9 Trace Elements Phase 3,Phase 2,Phase 1,Early Phase 1
10 topoisomerase I inhibitors Phase 3,Phase 2,Phase 1
11 Bone Density Conservation Agents Phase 3,Phase 2,Phase 1,Early Phase 1
12 Micronutrients Phase 3,Phase 2,Phase 1,Early Phase 1
13 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
14 Antidotes Phase 3,Phase 2,Phase 1
15 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
16 Nutrients Phase 3,Phase 2,Phase 1,Early Phase 1
17 Antimetabolites Phase 3,Phase 2,Phase 1
18 Hormones Phase 3,Phase 2,Phase 1,Early Phase 1
19 Vitamin B9 Phase 3,Phase 2,Phase 1
20 Antineoplastic Agents, Phytogenic Phase 3
21 Immunologic Factors Phase 3,Phase 2,Phase 1,Early Phase 1
22 Vitamin B Complex Phase 3,Phase 2,Phase 1
23 Folate Phase 3,Phase 2,Phase 1
24 Protective Agents Phase 3,Phase 2,Phase 1
25 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
26 Calcium, Dietary Phase 3,Phase 2,Phase 1,Early Phase 1
27 Tetrahydrofolates Phase 3,Phase 1
28 Formyltetrahydrofolates Phase 3,Phase 1
29 Vitamins Phase 3,Phase 2,Phase 1,Early Phase 1
30
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
31
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
32
Curcumin Approved, Experimental, Investigational Phase 2 458-37-7 969516
33
Turmeric Approved, Experimental, Investigational Phase 2
34
Panitumumab Approved, Investigational Phase 2 339177-26-3 50070211
35
Cetuximab Approved Phase 2,Phase 1,Early Phase 1 205923-56-4 56842117 2333
36
Ramucirumab Approved, Investigational Phase 2 947687-13-0
37
Indomethacin Approved, Investigational Phase 1, Phase 2 53-86-1 3715
38
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
39 Antineoplastic Agents, Immunological Phase 2,Phase 1,Early Phase 1
40 Angiogenesis Inhibitors Phase 2,Phase 1
41 Angiogenesis Modulating Agents Phase 2,Phase 1
42 Immunoglobulins Phase 2,Phase 1,Early Phase 1
43 Antibodies Phase 2,Phase 1,Early Phase 1
44 Antibodies, Monoclonal Phase 2,Phase 1,Early Phase 1
45 Cola Phase 2,Phase 1,Early Phase 1
46 Liver Extracts Phase 2,Phase 1,Early Phase 1
47 Protein Kinase Inhibitors Phase 2,Phase 1,Early Phase 1
48 Endothelial Growth Factors Phase 2
49 Mitogens Phase 2
50 Radiopharmaceuticals Phase 2

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Comparison of Adjuvant Chemotherapy Regimens in Treating Stage II/III Rectal Cancer Completed NCT00068692 Phase 3 Fluorouracil;Leucovorin Calcium;Oxaliplatin;Irinotecan
2 Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer Completed NCT00005036 Phase 3 irinotecan hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil
3 Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer Active, not recruiting NCT01652196 Phase 2 oxaliplatin;leucovorin;fluorouracil
4 Bevacizumab, Fluorouracil, Leucovorin Calcium, and Oxaliplatin Before Surgery in Treating Patients With Stage II-III Rectal Cancer Active, not recruiting NCT01871571 Phase 2 oxaliplatin;leucovorin calcium;fluorouracil
5 Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating Patients With Rectal Cancer Active, not recruiting NCT00745134 Phase 2 Capecitabine
6 Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery Active, not recruiting NCT01802320 Phase 2 Akt Inhibitor MK2206
7 Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab Active, not recruiting NCT01814501 Phase 2 irinotecan hydrochloride;fluorouracil;leucovorin calcium
8 Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy Active, not recruiting NCT01079780 Phase 2 irinotecan hydrochloride
9 Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From Metastatic Colon or Rectal Cancer Terminated NCT01285102 Phase 2
10 Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer Terminated NCT00002796 Phase 1, Phase 2 fluorouracil;sodium phenylbutyrate;indomethacin
11 Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent Colorectal Cancer Terminated NCT00052585 Phase 2 irinotecan hydrochloride;gefitinib;leucovorin calcium;fluorouracil
12 Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer Withdrawn NCT02235324 Phase 2 leucovorin calcium;fluorouracil
13 Irinotecan and Alisertib in Treating Patients With Advanced Solid Tumors or Colorectal Cancer Completed NCT01923337 Phase 1 irinotecan hydrochloride;alisertib
14 Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Rectal Cancer Completed NCT00003799 Phase 1 fluorouracil;oxaliplatin;leucovorin calcium
15 A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal Cancer Completed NCT00060411 Phase 1 erlotinib hydrochloride;fluorouracil;leucovorin calcium;oxaliplatin
16 Gene Therapy in Treating Patients With Cancer Completed NCT00004178 Phase 1
17 Phase I Study of Neoadjuvant Radiotherapy With 5-Fluorouracil for Rectal Cancer Active, not recruiting NCT02270606 Phase 1 fluorouracil;oxaliplatin;leucovorin calcium
18 CPI-613 and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery Active, not recruiting NCT02232152 Phase 1 6,8-bis(benzylthio)octanoic acid;fluorouracil
19 Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies Active, not recruiting NCT01643499 Phase 1 oxaliplatin;irinotecan hydrochloride;leucovorin calcium;fluorouracil
20 Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer Terminated NCT01198535 Phase 1 Gamma-Secretase Inhibitor RO4929097
21 Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal Cancer That Has Spread to the Liver Terminated NCT02110953 Phase 1
22 Adherence to Survivorship Care Guidelines in Health Care Providers for Non-Small Cell Lung Cancer and Colorectal Cancer Survivor Care Completed NCT01726296 Not Applicable
23 Genetic Mutations in Blood and Tissue Samples in Predicting Response to Treatment in Patients With Locally Advanced Rectal Cancer Undergoing Chemoradiation Recruiting NCT02132858
24 Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal Cancer Undergoing Chemotherapy Terminated NCT01934179
25 Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That Can Be Removed by Surgery Terminated NCT00835679 Early Phase 1 dasatinib
26 Cholecalciferol(25-[OH]-Vitamin D) in Treating Patients With Colorectal Cancer Withdrawn NCT01403103 Early Phase 1

Search NIH Clinical Center for Rectum Signet Ring Adenocarcinoma

Genetic Tests for Rectum Signet Ring Adenocarcinoma

Anatomical Context for Rectum Signet Ring Adenocarcinoma

MalaCards organs/tissues related to Rectum Signet Ring Adenocarcinoma:

42
Colon, Bone, Endothelial

Publications for Rectum Signet Ring Adenocarcinoma

Articles related to Rectum Signet Ring Adenocarcinoma:

# Title Authors Year
1
Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review. ( 22429319 )
2013
2
Signet-ring cell adenocarcinoma of rectum: a histological, histochemical and electron microscopic study. ( 6284632 )
1982

Variations for Rectum Signet Ring Adenocarcinoma

Expression for Rectum Signet Ring Adenocarcinoma

Search GEO for disease gene expression data for Rectum Signet Ring Adenocarcinoma.

Pathways for Rectum Signet Ring Adenocarcinoma

GO Terms for Rectum Signet Ring Adenocarcinoma

Sources for Rectum Signet Ring Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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