MCID: RCR022
MIFTS: 47

Recurrent Acute Pancreatitis

Categories: Bone diseases, Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Recurrent Acute Pancreatitis

Summaries for Recurrent Acute Pancreatitis

MalaCards based summary : Recurrent Acute Pancreatitis, also known as acute recurrent pancreatitis, is related to pancreatitis, hereditary and acute pancreatitis. An important gene associated with Recurrent Acute Pancreatitis is CFTR (CF Transmembrane Conductance Regulator), and among its related pathways/superpathways are Lipoprotein metabolism and Metabolism of fat-soluble vitamins. The drugs Simvastatin and Hypolipidemic Agents have been mentioned in the context of this disorder. Affiliated tissues include pancreas, kidney and testes, and related phenotypes are episodic abdominal pain and abnormality of circulating enzyme level

Related Diseases for Recurrent Acute Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Autoimmune Pancreatitis
Acute Pancreatitis Prss1-Related Hereditary Pancreatitis
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Recurrent Acute Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 pancreatitis, hereditary 32.2 SPINK1 PRSS1 CTRC CFTR
2 acute pancreatitis 30.3 SPINK1 SCT PRSS1 LPL CFTR
3 hypertriglyceridemia, familial 30.2 LPL APOE
4 pancreatitis 29.8 SPINK1 SCT PRSS1 LPL CTRC CFTR
5 duodenal atresia 29.7 SCT CFTR
6 biliary dyskinesia 29.7 SPINK1 SCT PRSS1 CFTR
7 autoimmune pancreatitis 29.7 PRSS1 CFTR
8 exocrine pancreatic insufficiency 29.5 SPINK1 SCT CFTR
9 prss1-related hereditary pancreatitis 29.4 SPINK1 PRSS1 CTRC CFTR
10 pancreatic adenocarcinoma 29.0 SPINK1 SCT PRSS1 CFTR
11 alcoholic pancreatitis 28.5 SPINK1 SCT PRSS1 LPL CFTR
12 lipodystrophy, familial partial, type 2 11.3
13 lipase deficiency, combined 11.3
14 gallbladder disease 1 10.3
15 duodenal obstruction 10.2 SPINK1 PRSS1
16 cystic fibrosis 10.2
17 hyperparathyroidism 10.2
18 pancreatic steatorrhea 10.1 SCT PRSS1
19 bile acid malabsorption, primary 10.1 SCT CFTR
20 primary hyperparathyroidism 10.1
21 pancreatic cancer 10.0
22 bile duct cysts 10.0
23 alcohol use disorder 10.0
24 adenoma 10.0
25 intussusception 10.0
26 cholelithiasis 10.0
27 arteriovenous malformation 10.0
28 cholangitis 10.0
29 biliary tract disease 10.0
30 chronic pain 10.0
31 hepatic lipase deficiency 10.0 LPL APOE
32 hyperlipoproteinemia, type iv 10.0 LPL APOE
33 tropical calcific pancreatitis 9.9 SPINK1 PRSS1 CTRC
34 hyperlipoproteinemia, type v 9.9 LPL APOE
35 pancreatic agenesis 1 9.9 SPINK1 SCT CFTR
36 hyperlipoproteinemia, type iii 9.9 LPL APOE
37 lecithin:cholesterol acyltransferase deficiency 9.9 LPL APOE
38 hyperalphalipoproteinemia 1 9.9 LPL APOE
39 apolipoprotein c-ii deficiency 9.9 LPL GPIHBP1
40 hypolipoproteinemia 9.9 LPL APOE
41 alcohol dependence 9.9
42 autoimmune disease 9.9
43 fibrosis of extraocular muscles, congenital, 1 9.9
44 systemic lupus erythematosus 9.9
45 pancreas, annular 9.9
46 inflammatory bowel disease 9.9
47 obstructive jaundice 9.9
48 neuroendocrine tumor 9.9
49 pulmonary tuberculosis 9.9
50 adenocarcinoma 9.9

Graphical network of the top 20 diseases related to Recurrent Acute Pancreatitis:



Diseases related to Recurrent Acute Pancreatitis

Symptoms & Phenotypes for Recurrent Acute Pancreatitis

Human phenotypes related to Recurrent Acute Pancreatitis:

58 31 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 episodic abdominal pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0002574
2 abnormality of circulating enzyme level 58 31 hallmark (90%) Very frequent (99-80%) HP:0011021
3 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
4 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
5 abnormal pancreatic duct morphology 58 31 frequent (33%) Frequent (79-30%) HP:0030992
6 pancreatic pseudocyst 58 31 frequent (33%) Frequent (79-30%) HP:0005206
7 biliary tract obstruction 58 31 frequent (33%) Frequent (79-30%) HP:0005230
8 chronic pancreatitis 58 31 frequent (33%) Frequent (79-30%) HP:0006280
9 sphincter of oddi dyskinesia 58 31 frequent (33%) Frequent (79-30%) HP:0012441
10 fever 58 31 occasional (7.5%) Occasional (29-5%) HP:0001945
11 hypertriglyceridemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002155
12 elevated hepatic transaminase 58 31 occasional (7.5%) Occasional (29-5%) HP:0002910
13 jaundice 58 31 occasional (7.5%) Occasional (29-5%) HP:0000952
14 oliguria 58 31 occasional (7.5%) Occasional (29-5%) HP:0100520
15 cholesterol gallstones 58 31 occasional (7.5%) Occasional (29-5%) HP:0011980
16 biliary hyperplasia 58 31 occasional (7.5%) Occasional (29-5%) HP:0006560
17 pancreas divisum 58 31 occasional (7.5%) Occasional (29-5%) HP:0030994
18 seizures 58 31 very rare (1%) Very rare (<4-1%) HP:0001250
19 type i diabetes mellitus 58 31 very rare (1%) Very rare (<4-1%) HP:0100651
20 ascites 58 31 very rare (1%) Very rare (<4-1%) HP:0001541
21 respiratory distress 58 31 very rare (1%) Very rare (<4-1%) HP:0002098
22 leukemia 58 31 very rare (1%) Very rare (<4-1%) HP:0001909
23 lymphoma 58 31 very rare (1%) Very rare (<4-1%) HP:0002665
24 systemic lupus erythematosus 58 31 very rare (1%) Very rare (<4-1%) HP:0002725
25 gastrointestinal dysmotility 58 31 very rare (1%) Very rare (<4-1%) HP:0002579
26 cyst of the ductus choledochus 58 31 very rare (1%) Very rare (<4-1%) HP:0100890
27 cholelithiasis 58 Occasional (29-5%)

GenomeRNAi Phenotypes related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased LDL uptake GR00340-A-1 8.62 APOE LPL

Drugs & Therapeutics for Recurrent Acute Pancreatitis

Drugs for Recurrent Acute Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 3 79902-63-9 54454
2 Hypolipidemic Agents Phase 3
3 Anticholesteremic Agents Phase 3
4 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
5 Antimetabolites Phase 3
6 Lipid Regulating Agents Phase 3
7
Amlodipine Approved Phase 1, Phase 2 88150-42-9 2162
8
Pancrelipase Approved, Investigational Phase 2 53608-75-6
9
Nitric Oxide Approved Phase 2 10102-43-9 145068
10
Calcium Approved, Nutraceutical Phase 1, Phase 2 7440-70-2 271
11 Hormones Phase 1, Phase 2
12 Antihypertensive Agents Phase 1, Phase 2
13 calcium channel blockers Phase 1, Phase 2
14 Calcium, Dietary Phase 1, Phase 2
15 Vasodilator Agents Phase 1, Phase 2
16 pancreatin Phase 2
17 Liver Extracts Phase 2
18 insulin Phase 2
19 Insulin, Globin Zinc Phase 2
20
Secretin Approved Phase 1 108153-74-8
21 Gastrointestinal Agents Phase 1
22 Hormone Antagonists Phase 1
23
Diclofenac Approved, Vet_approved 15307-86-5 3033
24
Ethanol Approved 64-17-5 702
25
Methylene blue Approved, Investigational 61-73-4
26
Indomethacin Approved, Investigational 53-86-1 3715
27 Anti-Inflammatory Agents
28 Anti-Inflammatory Agents, Non-Steroidal
29 Analgesics, Non-Narcotic
30 Cyclooxygenase Inhibitors
31 Antirheumatic Agents
32 Analgesics
33 Central Nervous System Depressants
34 Anti-Infective Agents, Local
35 Anti-Infective Agents

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Phase III Study to Demonstrate the Efficacy and Safety of RG1068 (Synthetic Human Secretin)- Enhanced Magnetic Resonance Cholangiopancreatography (MRCP) in the Evaluation of Subjects With a History of Acute or Acute Recurrent Pancreatitis Completed NCT00660335 Phase 3 RG1068 (synthetic human secretin)
2 Simvastatin in the Prevention of Recurrent Pancreatitis, a Triple Blind, Randomized Controlled Trial Recruiting NCT04021498 Phase 3 Simvastatin 40mg
3 Hereditary Pancreatitis Amlodipine Trial(H-PAT): A Pilot Study Completed NCT00156403 Phase 1, Phase 2 amlodipine (drug)
4 Nitrite Infusion in Islet Cell Transplantation: Test of Clinical Efficacy and Determination of Cytoprotective Mechanisms Terminated NCT03544242 Phase 2 Pre-Isolation Infusion;Post-Isolation Infusion
5 RG1068 (Synthetic Human Secretin) Enhanced MRCP for Morphological Evaluation of the Pancreatic Duct in the Pediatric Population Terminated NCT00621283 Phase 1 RG1068 (Synthetic Human Secretin)
6 Intramuscular Diclofenac in the Prevention of Post-ERCP Pancreatitis Unknown status NCT01717599 Diclofenac;normal saline
7 Endoscopic Versus Surgical Treatment of Chronic Pancreatitis - A Randomized Controlled Trial Unknown status NCT01520675
8 The IRAP Registry is a Multi-center Prospective, Collaborative Database Designed to Create a National Registry That Collects Information Concerning Episodes of Idiopathic Recurrent Acute Pancreatitis From Major 'Pancreas' Centers. Intent is to do a Comparative Effectiveness Study of Interventions. Completed NCT01133535
9 Defining the Role of ERCP in the Evaluation and Treatment of Idiopathic Recurrent Acute Pancreatitis Completed NCT01583517
10 Recurrence of Acute Alcoholic Pancreatitis Completed NCT00523874
11 The North American Pancreatitis Study Completed NCT01545167
12 Randomized Clinical Trial of the Effect of Standard Versus Intensive Intervention Protocol in Attempting to Reduce Recurrent Episodes of Acute Alcoholic Pancreatitis Completed NCT00534534
13 SpHincterotomy for Acute Recurrent Pancreatitis (SHARP Trial) Recruiting NCT03609944
14 Characterization of Fibro-inflammation During Progression From Acute to Chronic Pancreatitis Recruiting NCT03853447
15 Development and Feasibility Testing of an Internet-based Pain Self-management Program for Persons With Acute Recurrent and Chronic Pancreatitis Pain (The IMPACT Study) Recruiting NCT03322644
16 Extracorporeal Shock Wave Lithotripsy Versus Single Operator Pancreatoscopy and Intraductal Lithotripsy for the Treatment of Pancreatic Duct Stones Recruiting NCT04158297
17 QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing Recruiting NCT03434392
18 Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) CPDPC16-03 Pediatric Longitudinal Cohort Study of Chronic Pancreatitis Recruiting NCT03672422
19 Urine Trypsinogen 2 Dipstick for the Early Detection of Post-ERCP Pancreatitis Recruiting NCT03098082

Search NIH Clinical Center for Recurrent Acute Pancreatitis

Genetic Tests for Recurrent Acute Pancreatitis

Genetic tests related to Recurrent Acute Pancreatitis:

# Genetic test Affiliating Genes
1 Acute Recurrent Pancreatitis 29

Anatomical Context for Recurrent Acute Pancreatitis

MalaCards organs/tissues related to Recurrent Acute Pancreatitis:

40
Pancreas, Kidney, Testes, Liver, Spleen, Colon, Smooth Muscle

Publications for Recurrent Acute Pancreatitis

Articles related to Recurrent Acute Pancreatitis:

(show top 50) (show all 736)
# Title Authors PMID Year
1
Recurrent acute pancreatitis caused by association of a novel mutation of the calcium-sensing receptor gene and a heterozygous mutation of the SPINK1 gene. 54 61
20335783 2010
2
Connections between genetics and clinical data: Role of MCP-1, CFTR, and SPINK-1 in the setting of acute, acute recurrent, and chronic pancreatitis. 54 61
19844201 2010
3
Association of SPINK1 gene mutation and CFTR gene polymorphisms in patients with pancreas divisum presenting with idiopathic pancreatitis. 54 61
19593166 2009
4
Cystic fibrosis transmembrane conductance regulator ion channel function testing in recurrent acute pancreatitis. 54 61
18360295 2008
5
MRCP-secretin test-guided management of idiopathic recurrent pancreatitis: long-term outcomes. 54 61
18179795 2008
6
Endoscopic therapy in acute recurrent pancreatitis. 54 61
18286684 2008
7
New advances in acute pancreatitis. 54 61
17762554 2007
8
Association of pancreas divisum and recurrent acute pancreatitis with the IVS8-5T-12TG allele of the CFTR gene and CFTR dysfunction. 54 61
17575549 2007
9
[Acute recurrent pancreatitis in a composite CFTR heterozygote and Spink1 heterozygote patient]. 54 61
16733393 2006
10
Recurrent acute and chronic pancreatitis in two brothers with familial chylomicronemia syndrome. 54 61
16552344 2006
11
The cystic fibrosis transmembrane conductance regulator gene and ion channel function in patients with idiopathic pancreatitis. 54 61
16193325 2005
12
Chronic pancreatitis. 54 61
16093768 2005
13
Motility and dysmotility of the biliary tract. 54 61
14719770 2003
14
Mutations in the SPINK1 gene in idiopathic pancreatitis Italian patients. 54 61
12825076 2003
15
Is secretin magnetic resonance cholangio-pancreatography an effective guide for a diagnostic and/or therapeutic flow-chart in acute recurrent pancreatitis? 54 61
11880701 2001
16
Comparison of ultrasound-secretin test and sphincter of Oddi manometry in patients with recurrent acute pancreatitis. 54 61
10063920 1999
17
Ultrasonography-secretin test pattern after acute administration of octreotide in healthy persons and in patients with recurrent acute pancreatitis. 54 61
9252847 1997
18
Botulinum toxin injection as a diagnostic tool for verification of sphincter of Oddi dysfunction causing recurrent pancreatitis. 54 61
9101150 1997
19
Abnormal US response of main pancreatic duct after secretin stimulation in patients with acute pancreatitis of different etiology. 54 61
8071514 1994
20
Radiomic features of the pancreas on CT imaging accurately differentiate functional abdominal pain, recurrent acute pancreatitis, and chronic pancreatitis. 61
31846864 2020
21
Endoscopic Retrograde Cholangiopancreatography in Recurrent Acute Pancreatitis: Determining the Optimal Subgroup of Patients in Whom the Procedure is Beneficial. 61
32013322 2020
22
Novel therapeutics in hypertriglyceridaemia and chylomicronaemia. 61
31932043 2020
23
Genetic Evaluation of Children with Idiopathic Recurrent Acute Pancreatitis. 61
31900721 2020
24
Practice Patterns and Use of Endoscopic Retrograde Cholangiopancreatography in the Management of Recurrent Acute Pancreatitis. 61
31273969 2020
25
Risk factors of recurrent pancreatitis after first acute pancreatitis attack: a retrospective cohort study. 61
31822144 2020
26
Unique circulating immune signatures for recurrent acute pancreatitis, chronic pancreatitis and pancreatic cancer: A pilot study of these conditions with and without diabetes. 61
31791885 2020
27
Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H. 61
31550238 2020
28
American Gastroenterological Association Clinical Practice Update: Management of Pancreatic Necrosis. 61
31479658 2020
29
When Pancreatitis Stinks: A Rare Cause of Acute Recurrent Pancreatitis in a Child. 61
31856096 2020
30
Recurrent Pancreatitis in Children: Past, Present, and Future. 61
31899736 2019
31
Functional Pancreatic Sphincter Dysfunction in Children: Recommendations for Diagnosis and Management. 61
31567892 2019
32
Cystic fibrosis transmembrane conductance regulator modulators reduce the risk of recurrent acute pancreatitis among adult patients with pancreas sufficient cystic fibrosis. 61
31611131 2019
33
Familial chylomicronemia syndrome: an under-recognized cause of severe hypertriglyceridaemia. 61
31840878 2019
34
Endoscopic management of Wirsungocele with recurrent acute pancreatitis. 61
31791094 2019
35
Colonic hematoma after extracorporeal shock wave lithotripsy for pancreatic stones: a case report. 61
31801483 2019
36
Identification and management of pancreas divisum. 61
31663403 2019
37
Acute pancreatitis and recurrent acute pancreatitis: an exploration of clinical and etiologic factors and outcomes. 61
30075118 2019
38
Chronic pancreatitis in children: treat like an adult? 61
31753827 2019
39
Efficacy of therapeutic plasma exchange in reducing the incidence of recurrent pancreatitis related to familial chylomicronemia. 61
31568575 2019
40
Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data From the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort. 61
31651815 2019
41
Cystic fibrosis transmembrane conductance regulator functional evaluations in a G542X+/- IVS8Tn:T7/9 patient with acute recurrent pancreatitis. 61
31799301 2019
42
Case report on Ansa Pancreatica: An Uncommon Cause Accounting for Recurrent Pancreatitis in Children. 61
31740899 2019
43
Meandering Main Pancreatic Duct in Association with Choledochal Cysts and Acute Pancreatitis in Pediatrics. 61
31610001 2019
44
Endoscopic Management of Recurrent Acute Pancreatitis. 61
31077835 2019
45
SpHincterotomy for Acute Recurrent Pancreatitis Randomized Trial: Rationale, Methodology, and Potential Implications. 61
31404020 2019
46
Use of Insulin and the Risk of Progression of Pancreatitis: A Population-Based Cohort Study. 61
31553055 2019
47
Cinacalcet sustainedly prevents pancreatitis in a child with a compound heterozygous SPINK1/AP2S1 mutation. 61
31391146 2019
48
Recurrent acute pancreatitis caused by duodenal duplication cyst in a young patient. 61
31534757 2019
49
Total pancreatectomy with islet autotransplantation in a pancreatic-sufficient cystic fibrosis patient. 61
31420175 2019
50
Long-term outcomes of therapeutic ERCP in pediatric patients with pancreas divisum presenting with acute recurrent or chronic pancreatitis. 61
31421974 2019

Variations for Recurrent Acute Pancreatitis

Expression for Recurrent Acute Pancreatitis

Search GEO for disease gene expression data for Recurrent Acute Pancreatitis.

Pathways for Recurrent Acute Pancreatitis

Pathways related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.08 LPL GPIHBP1 APOE
2
Show member pathways
11.76 LPL GPIHBP1 APOE
3
Show member pathways
11.63 PRSS1 LPL GPIHBP1 CTRC APOE
4 11.14 SCT PRSS1 CFTR
5
Show member pathways
11.09 SOD1 CFTR
6 10.48 PRSS1 CTRC

GO Terms for Recurrent Acute Pancreatitis

Cellular components related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 SPINK1 SOD1 SCT PRSS1 LPL APOE
2 very-low-density lipoprotein particle GO:0034361 9.26 LPL APOE
3 extracellular region GO:0005576 9.23 SPINK1 SOD1 SCT PRSS1 LPL GPIHBP1
4 chylomicron GO:0042627 9.16 LPL APOE

Biological processes related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cholesterol homeostasis GO:0042632 9.61 LPL GPIHBP1 APOE
2 response to nutrient levels GO:0031667 9.52 SOD1 SCT
3 triglyceride metabolic process GO:0006641 9.51 LPL APOE
4 sperm capacitation GO:0048240 9.49 SPINK1 CFTR
5 cobalamin metabolic process GO:0009235 9.48 PRSS1 CTRC
6 response to reactive oxygen species GO:0000302 9.46 SOD1 APOE
7 regulation of lipoprotein lipase activity GO:0051004 9.4 LPL GPIHBP1
8 negative regulation of cholesterol biosynthetic process GO:0045541 9.37 SOD1 APOE
9 retinoid metabolic process GO:0001523 9.33 LPL GPIHBP1 APOE
10 very-low-density lipoprotein particle remodeling GO:0034372 9.32 LPL APOE
11 protein import GO:0017038 9.26 GPIHBP1 APOE
12 triglyceride homeostasis GO:0070328 9.13 LPL GPIHBP1 APOE
13 chylomicron remodeling GO:0034371 8.8 LPL GPIHBP1 APOE

Molecular functions related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.43 SCT LPL APOE
2 antioxidant activity GO:0016209 9.16 SOD1 APOE
3 heparan sulfate proteoglycan binding GO:0043395 8.96 LPL APOE
4 lipoprotein particle binding GO:0071813 8.8 LPL GPIHBP1 APOE

Sources for Recurrent Acute Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....