MCID: RCR022
MIFTS: 44

Recurrent Acute Pancreatitis

Categories: Bone diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Recurrent Acute Pancreatitis

MalaCards integrated aliases for Recurrent Acute Pancreatitis:

Name: Recurrent Acute Pancreatitis 59
Acute Recurrent Pancreatitis 29 55 73

Characteristics:

Orphanet epidemiological data:

59
recurrent acute pancreatitis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: All ages;

Classifications:



External Ids:

Orphanet 59 ORPHA64740
ICD10 via Orphanet 34 K85.9 K85.0 K85.1 more
UMLS via Orphanet 74 C0267937
UMLS 73 C0267937

Summaries for Recurrent Acute Pancreatitis

MalaCards based summary : Recurrent Acute Pancreatitis, also known as acute recurrent pancreatitis, is related to acute pancreatitis and pancreatitis. An important gene associated with Recurrent Acute Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Lipoprotein metabolism and Metabolism of fat-soluble vitamins. Affiliated tissues include pancreas, testes and liver, and related phenotype is Increased LDL uptake.

Related Diseases for Recurrent Acute Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Autoimmune Pancreatitis
Acute Pancreatitis Prss1-Related Hereditary Pancreatitis
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Recurrent Acute Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 acute pancreatitis 31.0 CFTR LPL SCT SPINK1
2 pancreatitis 30.6 CFTR CTRC LPL PRSS1 SCT SPINK1
3 cystic fibrosis 30.0 CFTR PRSS1 SCT SPINK1
4 pancreatitis, hereditary 29.3 CFTR CTRC PRSS1 SPINK1
5 lipodystrophy, familial partial, type 2 11.1
6 duodenal atresia 10.1 CFTR SCT
7 steatorrhea 10.1 CFTR SCT
8 pancreatic steatorrhea 10.1 PRSS1 SCT
9 autoimmune pancreatitis 10.1 CFTR PRSS1
10 apolipoprotein c-ii deficiency 10.0 GPIHBP1 LPL
11 pancreatic agenesis 1 10.0 CFTR SCT SPINK1
12 familial lipoprotein lipase deficiency 10.0 GPIHBP1 LPL
13 hyperparathyroidism 10.0
14 exocrine pancreatic insufficiency 10.0 CFTR SCT SPINK1
15 tropical calcific pancreatitis 10.0 CTRC PRSS1 SPINK1
16 hepatic lipase deficiency 10.0 APOE LPL
17 hyperlipoproteinemia, type v 10.0 APOE LPL
18 primary hyperparathyroidism 10.0
19 ischemic heart disease 10.0 APOE LPL
20 hypolipoproteinemia 10.0 APOE LPL
21 hypertriglyceridemia, familial 10.0 APOE LPL
22 xanthomatosis 10.0 APOE LPL
23 hyperlipoproteinemia, type iii 10.0 APOE LPL
24 gallbladder disease 9.9 APOE CFTR
25 hyperalphalipoproteinemia 1 9.9 APOE LPL
26 lecithin:cholesterol acyltransferase deficiency 9.9 APOE LPL
27 biliary dyskinesia 9.9
28 abetalipoproteinemia 9.9 APOE LPL
29 pancreas disease 9.9 CFTR PRSS1 SCT SPINK1
30 tangier disease 9.9 APOE LPL
31 intussusception 9.8
32 pancreas, annular 9.8
33 pancreatic cancer 9.8
34 arteriovenous malformation 9.8
35 neuroendocrine tumor 9.8
36 purpura 9.8
37 kidney disease 9.8
38 adenoma 9.8
39 wandering spleen 9.8
40 familial hyperlipidemia 9.8 APOE LPL
41 lipid metabolism disorder 9.8 APOE LPL
42 alcoholic pancreatitis 9.7 CFTR LPL PRSS1 SCT SPINK1
43 autoimmune disease 9.7
44 hepatocellular carcinoma 9.7
45 systemic lupus erythematosus 9.7
46 hemangiopericytoma, malignant 9.7
47 isovaleric acidemia 9.7
48 sjogren syndrome 9.7
49 bile duct cysts 9.7
50 ascaris lumbricoides infection 9.7

Graphical network of the top 20 diseases related to Recurrent Acute Pancreatitis:



Diseases related to Recurrent Acute Pancreatitis

Symptoms & Phenotypes for Recurrent Acute Pancreatitis

GenomeRNAi Phenotypes related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased LDL uptake GR00340-A-1 8.62 APOE LPL

Drugs & Therapeutics for Recurrent Acute Pancreatitis

Search Clinical Trials , NIH Clinical Center for Recurrent Acute Pancreatitis

Genetic Tests for Recurrent Acute Pancreatitis

Genetic tests related to Recurrent Acute Pancreatitis:

# Genetic test Affiliating Genes
1 Acute Recurrent Pancreatitis 29

Anatomical Context for Recurrent Acute Pancreatitis

MalaCards organs/tissues related to Recurrent Acute Pancreatitis:

41
Pancreas, Testes, Liver, Bone, Kidney, Spleen, Heart

Publications for Recurrent Acute Pancreatitis

Articles related to Recurrent Acute Pancreatitis:

(show top 50) (show all 284)
# Title Authors Year
1
A Tale of Three Tails and a Cystic Lesion: A Rare Cause of Recurrent Acute Pancreatitis. ( 29961770 )
2018
2
Secondary Hypertriglyceridemia Causing Recurrent Acute Pancreatitis with Normal Pancreatic Enzymes. ( 29910554 )
2018
3
Recurrent Acute Pancreatitis in Children: Do not forget the "Worms". ( 29095350 )
2018
4
Intraductal tubulopapillary neoplasm of the pancreas presenting as recurrent acute pancreatitis: A case report. ( 29906691 )
2018
5
Colopancreatic Fistula: An Uncommon Complication of Recurrent Acute Pancreatitis. ( 29785309 )
2018
6
Total pancreatectomy and islet autotransplantion for chronic and recurrent acute pancreatitis. ( 29901515 )
2018
7
Gastrointestinal: Recurrent acute pancreatitis with a large fluid collection: Pseudocyst or else? ( 29659085 )
2018
8
Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis. ( 29867178 )
2018
9
Recurrent Acute Pancreatitis: International State-of-the-Science Conference With Recommendations. ( 29894415 )
2018
10
Compound but non-linked heterozygous p.W14X and p.L279A V LPL gene mutations in a Chinese patient with long-term severe hypertriglyceridemia and recurrent acute pancreatitis. ( 29921298 )
2018
11
Pancreaticoportal Fistula Formation as a Consequence of Recurrent Acute Pancreatitis: Clinical and Imaging Considerations. ( 29441227 )
2018
12
Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Recurrent Acute Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop. ( 30325857 )
2018
13
Clinico-radiological comparison and short-term prognosis of single acute pancreatitis and recurrent acute pancreatitis including pancreatic volumetry. ( 30359398 )
2018
14
Assessing the CT findings and clinical course of ED patients with first-time versus recurrent acute pancreatitis. ( 30471931 )
2018
15
Differences between the outcome of recurrent acute pancreatitis and acute pancreatitis. ( 30483578 )
2018
16
Acute pancreatitis and recurrent acute pancreatitis: an exploration of clinical and etiologic factors and outcomes. ( 30075118 )
2018
17
Recurrent acute pancreatitis due to pancreatic duct ascariasis in a young man. ( 30096718 )
2018
18
Recurrent acute pancreatitis in a toddler: a "wormy surprise". ( 30175310 )
2018
19
The Quality of Life Measurement in Recurrent Acute Pancreatitis Needs to be More Accurate. ( 30214013 )
2018
20
Idiopathic recurrent acute pancreatitis. ( 30215363 )
2018
21
Recurrent Acute Pancreatitis: Current Concepts in the Diagnosis and Management. ( 30232693 )
2018
22
Rapid Progression of Acute Pancreatitis to Acute Recurrent Pancreatitis in Children. ( 30234758 )
2018
23
Is It Acute Pancreatitis or Recurrent Acute Pancreatitis Leading to Chronic Pancreatitis that Increases Pancreatic Cancer Risk? ( 30236555 )
2018
24
The Role of Endotherapy in Recurrent Acute Pancreatitis. ( 30241638 )
2018
25
The Importance of Recognizing Wandering Spleen as a Cause of Recurrent Acute Pancreatitis. ( 30034889 )
2018
26
Recurrent Acute Pancreatitis Caused by Mucin-Producing Liver Metastases. ( 30039033 )
2018
27
In-hospital and 90-day outcomes after total pancreatectomy with islet autotransplantation for pediatric chronic and acute recurrent pancreatitis. ( 30372594 )
2018
28
Incomplete functional and morphological recovery after acute and acute recurrent pancreatitis in children. ( 29791723 )
2018
29
Yield of Endoscopic Ultrasound in Children and Adolescent With Acute Recurrent Pancreatitis. ( 29216022 )
2018
30
A rare etiology of idiopathic recurrent acute pancreatitis. ( 28355653 )
2017
31
Genetics in idiopathic pancreatitis and acute recurrent pancreatitis. ( 28229614 )
2017
32
Reply to: Yang et al, Clinical Features of Recurrent Acute Pancreatitis: Experience From a Single Center. ( 28426494 )
2017
33
Eosinophilic Pancreatitis: A Rare Cause of Recurrent Acute Pancreatitis. ( 28611564 )
2017
34
Plasmapheresis for recurrent acute pancreatitis from hypertriglyceridemia. ( 28670087 )
2017
35
The Value of Secretin-Enhanced MRCP in Patients With Recurrent Acute Pancreatitis. ( 27824485 )
2017
36
Endoscopic Placement of a U-Shaped Plastic Stent in Patients With Recurrent Acute Pancreatitis and Incomplete Pancreas Divisum. ( 29215619 )
2017
37
Severe hypertriglyceridemia due to two novel loss-of-function lipoprotein lipase gene mutations (C310R/E396V) in a Chinese family associated with recurrent acute pancreatitis. ( 28548960 )
2017
38
Increased oxidative stress and deficient antioxidant levels may be involved in the pathogenesis of idiopathic recurrent acute pancreatitis. ( 28687456 )
2017
39
A Rare Etiology of Idiopathic Recurrent Acute Pancreatitis. ( 28384455 )
2017
40
A rare cause of recurrent acute pancreatitis: duodenum intussusception by a fenestrated duodenal web. ( 28342893 )
2017
41
R248G cystic fibrosis transmembrane conductance regulator mutation in three siblings presenting with recurrent acute pancreatitis and reproductive issues: a case series. ( 28196530 )
2017
42
Clinical Features of Recurrent Acute Pancreatitis: Experience From a Single Center. ( 28426493 )
2017
43
A Rare Cause of Recurrent Acute Pancreatitis in a Child: Isovaleric Acidemia with Novel Mutation. ( 28401058 )
2017
44
Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy. ( 28596690 )
2017
45
Is acute recurrent pancreatitis in children a precursor of chronic pancreatitis? A long-term follow-up study of 93 cases. ( 28320629 )
2017
46
Targeted Gene Next-Generation Sequencing in Chinese Children with Chronic Pancreatitis and Acute Recurrent Pancreatitis. ( 29173301 )
2017
47
Recurrent acute pancreatitis in bowel malrotation. ( 27906430 )
2016
48
Ansa pancreatica as a predisposing factor for recurrent acute pancreatitis. ( 27833385 )
2016
49
Henoch-SchAPnlein Purpura: A Rare Cause of Recurrent Acute Pancreatitis. ( 27748349 )
2016
50
Recurrent Acute Pancreatitis: A Diagnostic Clue to Primary Hyperparathyroidism. ( 27365562 )
2016

Variations for Recurrent Acute Pancreatitis

Expression for Recurrent Acute Pancreatitis

Search GEO for disease gene expression data for Recurrent Acute Pancreatitis.

Pathways for Recurrent Acute Pancreatitis

Pathways related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.97 APOE GPIHBP1 LPL
2
Show member pathways
11.66 APOE GPIHBP1 LPL
3
Show member pathways
11.63 APOE CTRC GPIHBP1 LPL PRSS1
4
Show member pathways
11.09 CFTR SOD1
5 10.28 CTRC PRSS1

GO Terms for Recurrent Acute Pancreatitis

Cellular components related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 APOE LPL PRSS1 SCT SOD1 SPINK1
2 high-density lipoprotein particle GO:0034364 9.32 APOE GPIHBP1
3 very-low-density lipoprotein particle GO:0034361 9.26 APOE LPL
4 extracellular region GO:0005576 9.23 APOE CTRC GPIHBP1 LPL PRSS1 SCT
5 chylomicron GO:0042627 9.16 APOE LPL

Biological processes related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cholesterol biosynthetic process GO:0006695 9.52 APOE CFTR
2 triglyceride metabolic process GO:0006641 9.51 APOE LPL
3 triglyceride catabolic process GO:0019433 9.49 APOE LPL
4 sperm capacitation GO:0048240 9.48 CFTR SPINK1
5 cobalamin metabolic process GO:0009235 9.46 CTRC PRSS1
6 response to reactive oxygen species GO:0000302 9.43 APOE SOD1
7 cholesterol homeostasis GO:0042632 9.43 APOE GPIHBP1 LPL
8 negative regulation of cholesterol biosynthetic process GO:0045541 9.4 APOE SOD1
9 regulation of lipoprotein lipase activity GO:0051004 9.37 GPIHBP1 LPL
10 very-low-density lipoprotein particle remodeling GO:0034372 9.32 APOE LPL
11 chylomicron remodeling GO:0034371 9.16 APOE LPL
12 protein import GO:0017038 8.96 APOE GPIHBP1
13 triglyceride homeostasis GO:0070328 8.8 APOE GPIHBP1 LPL

Molecular functions related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antioxidant activity GO:0016209 8.96 APOE SOD1
2 lipoprotein particle binding GO:0071813 8.62 APOE GPIHBP1

Sources for Recurrent Acute Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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