MCID: RCR022
MIFTS: 42

Recurrent Acute Pancreatitis

Categories: Gastrointestinal diseases, Rare diseases, Endocrine diseases, Genetic diseases, Bone diseases, Immune diseases

Aliases & Classifications for Recurrent Acute Pancreatitis

MalaCards integrated aliases for Recurrent Acute Pancreatitis:

Name: Recurrent Acute Pancreatitis 59
Acute Recurrent Pancreatitis 29 55 73

Characteristics:

Orphanet epidemiological data:

59
recurrent acute pancreatitis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: All ages;

Classifications:



External Ids:

Orphanet 59 ORPHA64740
ICD10 via Orphanet 34 K85.9 K85.0 K85.1 more
UMLS via Orphanet 74 C0267937
UMLS 73 C0267937

Summaries for Recurrent Acute Pancreatitis

MalaCards based summary : Recurrent Acute Pancreatitis, also known as acute recurrent pancreatitis, is related to acute pancreatitis and cystic fibrosis. An important gene associated with Recurrent Acute Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Lipoprotein metabolism and Metabolism of fat-soluble vitamins. The drugs Secretin and Pancrelipase have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and smooth muscle, and related phenotype is Increased LDL uptake.

Related Diseases for Recurrent Acute Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Acute Pancreatitis
Prss1-Related Hereditary Pancreatitis Autoimmune Pancreatitis
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Recurrent Acute Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 acute pancreatitis 30.9 LPL SCT SPINK1
2 cystic fibrosis 29.5 CFTR PRSS1 SCT SPINK1
3 pancreatitis 28.6 CFTR CTRC LPL PRSS1 SCT SPINK1
4 pancreatitis, hereditary 28.5 CFTR CTRC PRSS1 SPINK1
5 autoimmune pancreatitis 10.5 CFTR PRSS1
6 duodenal atresia 10.5 CFTR SCT
7 pancreatic steatorrhea 10.4 PRSS1 SCT
8 steatorrhea 10.4 CFTR SCT
9 exocrine pancreatic insufficiency 10.4 CFTR SCT
10 hyperlipoproteinemia, type v 10.2 APOE LPL
11 hepatic lipase deficiency 10.2 APOE LPL
12 hyperlipidemia, familial combined 10.2 APOE LPL
13 homozygous familial hypercholesterolemia 10.2 APOE LPL
14 hyperlipoproteinemia, type iv 10.2 APOE LPL
15 apolipoprotein c-ii deficiency 10.1 GPIHBP1 LPL
16 ischemic heart disease 10.1 APOE LPL
17 pancreatic agenesis 1 10.1 CFTR SCT SPINK1
18 familial lipoprotein lipase deficiency 10.1 GPIHBP1 LPL
19 hypolipoproteinemia 10.1 APOE LPL
20 duodenitis 10.1
21 pancreas disease 10.1 PRSS1 SCT SPINK1
22 xanthomatosis 10.1 APOE LPL
23 hyperlipoproteinemia, type iii 10.1 APOE LPL
24 hyperalphalipoproteinemia 1 10.0 APOE LPL
25 gallbladder disease 10.0 APOE CFTR
26 abetalipoproteinemia 10.0 APOE LPL
27 hyperparathyroidism 10.0
28 lecithin:cholesterol acyltransferase deficiency 10.0 APOE LPL
29 primary hyperparathyroidism 9.9
30 coronary heart disease 1 9.9 APOE LPL
31 familial hyperlipidemia 9.9 APOE LPL
32 tropical calcific pancreatitis 9.8 CTRC PRSS1 SPINK1
33 head injury 9.8 APOE SOD1
34 arteriovenous malformation 9.7
35 intussusception 9.7
36 neuroendocrine tumor 9.7
37 gastric duplication cysts 9.7
38 purpura 9.7
39 adenoma 9.7
40 tangier disease 9.7 APOE LPL
41 parathyroid adenoma 9.6
42 psoriatic arthritis 9.6
43 peritonitis 9.6
44 leukemia, acute lymphoblastic 9.6
45 arthritis 9.6
46 obstructive jaundice 9.6
47 eating disorder 9.6
48 hepatitis 9.6
49 hereditary angioedema 9.6
50 lupus erythematosus 9.6

Graphical network of the top 20 diseases related to Recurrent Acute Pancreatitis:



Diseases related to Recurrent Acute Pancreatitis

Symptoms & Phenotypes for Recurrent Acute Pancreatitis

GenomeRNAi Phenotypes related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased LDL uptake GR00340-A-1 8.62 APOE LPL

Drugs & Therapeutics for Recurrent Acute Pancreatitis

Drugs for Recurrent Acute Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Secretin Approved, Investigational Phase 3,Phase 1 108153-74-8
2
Pancrelipase Approved, Investigational Phase 3 53608-75-6
3 pancreatin Phase 3
4 Gastrointestinal Agents Phase 3,Phase 1
5 Hormone Antagonists Phase 3,Phase 1
6 Hormones Phase 3,Phase 1
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 1
8
Ethanol Approved Not Applicable 64-17-5 702

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Synthetic Human Secretin-Enhanced MRCP in Subjects With Abnormalities of the Pancreas Completed NCT00660335 Phase 3 RG1068 (synthetic human secretin)
2 Secretin Enhanced MRCP for Evaluation of Pancreatic Duct in Pediatric Population Terminated NCT00621283 Phase 1 RG1068 (Synthetic Human Secretin)
3 ERCP in Idiopathic Recurrent Acute Pancreatitis Completed NCT01583517 Not Applicable
4 Idiopathic Recurrent Acute Pancreatitis (IRAP) Completed NCT01133535
5 Recurrence of Acute Alcoholic Pancreatitis Completed NCT00523874
6 Trial of Index Cholecystectomy Versus Scheduled Cholecystectomy in Biliary Pancreatitis Completed NCT02630433 Not Applicable
7 The North American Pancreatitis Study Completed NCT01545167
8 Decrease of Recurrent Pancreatitis Completed NCT00534534 Not Applicable
9 QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing Recruiting NCT03434392 Not Applicable
10 Internet-based Pain Self-management for Persons With Acute Recurrent and Chronic Pancreatitis Pain Recruiting NCT03322644 Not Applicable

Search NIH Clinical Center for Recurrent Acute Pancreatitis

Genetic Tests for Recurrent Acute Pancreatitis

Genetic tests related to Recurrent Acute Pancreatitis:

# Genetic test Affiliating Genes
1 Acute Recurrent Pancreatitis 29

Anatomical Context for Recurrent Acute Pancreatitis

MalaCards organs/tissues related to Recurrent Acute Pancreatitis:

41
Pancreas, Testes, Smooth Muscle, Kidney, Pancreatic Islet

Publications for Recurrent Acute Pancreatitis

Articles related to Recurrent Acute Pancreatitis:

(show top 50) (show all 216)
# Title Authors Year
1
A Tale of Three Tails and a Cystic Lesion: A Rare Cause of Recurrent Acute Pancreatitis. ( 29961770 )
2018
2
Secondary Hypertriglyceridemia Causing Recurrent Acute Pancreatitis with Normal Pancreatic Enzymes. ( 29910554 )
2018
3
Recurrent Acute Pancreatitis in Children: Do not forget the "Worms". ( 29095350 )
2018
4
Intraductal tubulopapillary neoplasm of the pancreas presenting as recurrent acute pancreatitis: A case report. ( 29906691 )
2018
5
Colopancreatic Fistula: An Uncommon Complication of Recurrent Acute Pancreatitis. ( 29785309 )
2018
6
Total pancreatectomy and islet autotransplantion for chronic and recurrent acute pancreatitis. ( 29901515 )
2018
7
Gastrointestinal: Recurrent acute pancreatitis with a large fluid collection: Pseudocyst or else? ( 29659085 )
2018
8
Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis. ( 29867178 )
2018
9
Recurrent Acute Pancreatitis: International State-of-the-Science Conference With Recommendations. ( 29894415 )
2018
10
Compound but non-linked heterozygous p.W14X and p.L279A V LPL gene mutations in a Chinese patient with long-term severe hypertriglyceridemia and recurrent acute pancreatitis. ( 29921298 )
2018
11
Pancreaticoportal Fistula Formation as a Consequence of Recurrent Acute Pancreatitis: Clinical and Imaging Considerations. ( 29441227 )
2018
12
A rare etiology of idiopathic recurrent acute pancreatitis. ( 28355653 )
2017
13
Genetics in idiopathic pancreatitis and acute recurrent pancreatitis. ( 28229614 )
2017
14
Reply to: Yang et al, Clinical Features of Recurrent Acute Pancreatitis: Experience From a Single Center. ( 28426494 )
2017
15
Eosinophilic Pancreatitis: A Rare Cause of Recurrent Acute Pancreatitis. ( 28611564 )
2017
16
Plasmapheresis for recurrent acute pancreatitis from hypertriglyceridemia. ( 28670087 )
2017
17
The Value of Secretin-Enhanced MRCP in Patients With Recurrent Acute Pancreatitis. ( 27824485 )
2017
18
Endoscopic Placement of a U-Shaped Plastic Stent in Patients With Recurrent Acute Pancreatitis and Incomplete Pancreas Divisum. ( 29215619 )
2017
19
Severe hypertriglyceridemia due to two novel loss-of-function lipoprotein lipase gene mutations (C310R/E396V) in a Chinese family associated with recurrent acute pancreatitis. ( 28548960 )
2017
20
Increased oxidative stress and deficient antioxidant levels may be involved in the pathogenesis of idiopathic recurrent acute pancreatitis. ( 28687456 )
2017
21
A Rare Etiology of Idiopathic Recurrent Acute Pancreatitis. ( 28384455 )
2017
22
A rare cause of recurrent acute pancreatitis: duodenum intussusception by a fenestrated duodenal web. ( 28342893 )
2017
23
R248G cystic fibrosis transmembrane conductance regulator mutation in three siblings presenting with recurrent acute pancreatitis and reproductive issues: a case series. ( 28196530 )
2017
24
Clinical Features of Recurrent Acute Pancreatitis: Experience From a Single Center. ( 28426493 )
2017
25
A Rare Cause of Recurrent Acute Pancreatitis in a Child: Isovaleric Acidemia with Novel Mutation. ( 28401058 )
2017
26
Continuing episodes of pain in recurrent acute pancreatitis: Prospective follow up on a standardised protocol with drugs and pancreatic endotherapy. ( 28596690 )
2017
27
Recurrent acute pancreatitis in bowel malrotation. ( 27906430 )
2016
28
Ansa pancreatica as a predisposing factor for recurrent acute pancreatitis. ( 27833385 )
2016
29
Henoch-SchAPnlein Purpura: A Rare Cause of Recurrent Acute Pancreatitis. ( 27748349 )
2016
30
Recurrent Acute Pancreatitis: A Diagnostic Clue to Primary Hyperparathyroidism. ( 27365562 )
2016
31
Hereditary Angioedema Presenting as Recurrent Acute Pancreatitis. ( 26812927 )
2016
32
Endoscopic sphincterotomy (ES) may not alter the natural history of idiopathic recurrent acute pancreatitis (IRAP). ( 27450967 )
2016
33
Recurrent acute pancreatitis caused by pancreatic biliary maljunction due to long common channel. ( 28062875 )
2016
34
An Unusual Cause of Recurrent Acute Pancreatitis. ( 26658042 )
2016
35
Transcatheter embolization of pancreatic arteriovenous malformation associated with recurrent acute pancreatitis. ( 27081231 )
2016
36
Novel mutations in the GPIHBP1 gene identified in 2 patients with recurrent acute pancreatitis. ( 26892125 )
2016
37
Acute pancreatitis-induced thrombotic thrombocytopenic purpura with recurrent acute pancreatitis. ( 26905311 )
2016
38
Hyperparathyroidism as a cause of recurrent acute pancreatitis: A case report. ( 29341554 )
2016
39
A rare case report on recurrent acute pancreatitis secondary to primary hyperparathyroidism. ( 27728265 )
2016
40
Role of ERCP in Patients With Idiopathic Recurrent Acute Pancreatitis. ( 27371265 )
2016
41
Myofibroblastic Inflammatory Tumor Presenting as Recurrent Acute Pancreatitis and Obstructive Jaundice. ( 26405696 )
2015
42
An unusual retroperitoneal lesion causing recurrent acute pancreatitis. ( 26273777 )
2015
43
Genetic predisposition and its impact on natural history of idiopathic acute and acute recurrent pancreatitis in children. ( 25981744 )
2015
44
A B-wildering Case of Recurrent Acute Pancreatitis. ( 26026747 )
2015
45
Hepatobiliary and Pancreatic: Triad of recurrent acute pancreatitis, duodenal web and intra-pancreatic duodenal duplication cyst: a new constellation? ( 26458086 )
2015
46
Parathyroid adenoma in a young female presenting as recurrent acute pancreatitis with a brown tumour of the mandible-A case study. ( 25574767 )
2015
47
Endoscopic Treatment of Recurrent Acute Pancreatitis and Smoldering Acute Pancreatitis. ( 26431601 )
2015
48
The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population. ( 25569187 )
2015
49
Loperamide-induced recurrent acute pancreatitis. ( 26184348 )
2015
50
Recurrent acute pancreatitis secondary to Ascaris lumbricoides. ( 25851160 )
2015

Variations for Recurrent Acute Pancreatitis

Expression for Recurrent Acute Pancreatitis

Search GEO for disease gene expression data for Recurrent Acute Pancreatitis.

Pathways for Recurrent Acute Pancreatitis

Pathways related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.03 APOE GPIHBP1 LPL
2
Show member pathways
11.66 APOE GPIHBP1 LPL
3
Show member pathways
11.63 APOE CTRC GPIHBP1 LPL PRSS1
4
Show member pathways
11.03 CFTR SOD1
5 10.28 CTRC PRSS1

GO Terms for Recurrent Acute Pancreatitis

Cellular components related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.88 APOE CFTR LPL PRSS1 SOD1 SPINK1
2 extracellular matrix GO:0031012 9.54 APOE LPL SOD1
3 extracellular space GO:0005615 9.43 APOE LPL PRSS1 SCT SOD1 SPINK1
4 high-density lipoprotein particle GO:0034364 9.32 APOE GPIHBP1
5 very-low-density lipoprotein particle GO:0034361 9.26 APOE LPL
6 extracellular region GO:0005576 9.23 APOE CTRC GPIHBP1 LPL PRSS1 SCT
7 chylomicron GO:0042627 9.16 APOE LPL

Biological processes related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cholesterol biosynthetic process GO:0006695 9.54 APOE CFTR
2 cholesterol homeostasis GO:0042632 9.54 APOE GPIHBP1 LPL
3 triglyceride metabolic process GO:0006641 9.52 APOE LPL
4 triglyceride catabolic process GO:0019433 9.51 APOE LPL
5 sperm capacitation GO:0048240 9.49 CFTR SPINK1
6 cobalamin metabolic process GO:0009235 9.48 CTRC PRSS1
7 response to reactive oxygen species GO:0000302 9.46 APOE SOD1
8 very-low-density lipoprotein particle remodeling GO:0034372 9.43 APOE LPL
9 regulation of lipoprotein lipase activity GO:0051004 9.4 GPIHBP1 LPL
10 retinoid metabolic process GO:0001523 9.33 APOE GPIHBP1 LPL
11 protein import GO:0017038 9.32 APOE GPIHBP1
12 negative regulation of cholesterol biosynthetic process GO:0045541 9.26 APOE SOD1
13 triglyceride homeostasis GO:0070328 9.13 APOE GPIHBP1 LPL
14 chylomicron remodeling GO:0034371 8.8 APOE GPIHBP1 LPL

Molecular functions related to Recurrent Acute Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antioxidant activity GO:0016209 8.96 APOE SOD1
2 lipoprotein particle binding GO:0071813 8.62 APOE GPIHBP1

Sources for Recurrent Acute Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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