MCID: RCR001
MIFTS: 33

Recurrent Corneal Erosion

Categories: Eye diseases

Aliases & Classifications for Recurrent Corneal Erosion

MalaCards integrated aliases for Recurrent Corneal Erosion:

Name: Recurrent Corneal Erosion 12 15
Recurrent Erosion of Cornea 12 71
Recurrent Erosion Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11541
ICD9CM 34 371.42
SNOMED-CT 67 2055003
ICD10 32 H18.83
UMLS 71 C0155119

Summaries for Recurrent Corneal Erosion

MalaCards based summary : Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to corneal dystrophy, reis-bucklers type and corneal dystrophy, avellino type. An important gene associated with Recurrent Corneal Erosion is IL6 (Interleukin 6), and among its related pathways/superpathways are Yersinia infection and Spinal Cord Injury. The drugs Lubricant Eye Drops and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and liver.

Wikipedia : 74 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea's... more...

Related Diseases for Recurrent Corneal Erosion

Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
# Related Disease Score Top Affiliating Genes
1 corneal dystrophy, reis-bucklers type 31.5 TGFBI TBCD KRT3 KRT12 CHST6
2 corneal dystrophy, avellino type 31.4 TGFBI TBCD KRT3 COL8A2 CHST6
3 epithelial basement membrane dystrophy 30.7 TGFBI TBCD CHST6
4 keratitis, hereditary 30.4 KRT3 KRT12 IL6 IL1B CXCL8
5 lattice corneal dystrophy 29.9 TGFBI TBCD KRT12 CHST6
6 irregular astigmatism 29.8 TGFBI KRT3 KRT12 COL8A2
7 eye disease 29.6 TGFBI IL6 IL1B CXCL8 COL8A2
8 corneal edema 29.5 TGFBI KRT3 KRT12 IL1B COL8A2
9 keratoconus 29.4 TGFBI KRT3 KRT12 IL6 IL1B COL8A2
10 stromal dystrophy 29.3 TGFBI TBCD KRT3 KRT12 COL8A2 CHST6
11 corneal dystrophy 29.1 TGFBI TBCD KRT3 KRT12 COL8A2 COL17A1
12 granular corneal dystrophy 28.9 TGFBI TBCD KRT3 KRT12 COL8A2 CHST6
13 corneal disease 28.7 TGFBI KRT3 KRT12 IL6 IL1B CXCL8
14 epithelial recurrent erosion dystrophy 12.2
15 corneal dystrophy, groenouw type i 11.3
16 corneal dystrophy, lattice type i 11.3
17 corneal dystrophy, lattice type iiia 11.3
18 lattice corneal dystrophy type ii 11.3
19 idiopathic anterior uveitis 10.5 IL6 CXCL8
20 streptococcal toxic-shock syndrome 10.5 IL6 CXCL8
21 acute transverse myelitis 10.5 IL6 CXCL8
22 transverse myelitis 10.5 IL6 CXCL8
23 angelucci's syndrome 10.5 IL1B CXCL8
24 dermatitis, atopic, 8 10.5 IL1B CXCL8
25 prosthetic joint infection 10.5 IL6 IL1B
26 osteosclerotic myeloma 10.5 IL6 IL1B
27 periodontitis, chronic 10.5 IL6 IL1B
28 fuchs' heterochromic uveitis 10.5 IL6 CXCL8
29 esophagus melanoma 10.5 IL1B CXCL8
30 uremic pruritus 10.5 IL6 IL1B
31 indolent myeloma 10.4 IL6 IL1B
32 post-cardiac arrest syndrome 10.4 IL6 CXCL8
33 stachybotrys chartarum 10.4 IL6 IL1B
34 pseudopterygium 10.4 KRT3 KRT12
35 bone sarcoma 10.4 IL6 CXCL8
36 acute monoblastic leukemia 10.4 IL6 CXCL8
37 eales disease 10.4 IL6 IL1B
38 pyuria 10.4 IL6 CXCL8
39 denture stomatitis 10.4 IL6 CXCL8
40 chlamydia pneumonia 10.4 IL6 CXCL8
41 peptic esophagitis 10.3 IL6 IL1B CXCL8
42 esophagitis 10.3 IL6 IL1B CXCL8
43 irritant dermatitis 10.3 IL6 IL1B CXCL8
44 periapical periodontitis 10.3 IL6 IL1B CXCL8
45 periodontitis 10.3 IL6 IL1B CXCL8
46 dental pulp disease 10.3 IL6 IL1B CXCL8
47 bagassosis 10.3 IL6 IL1B CXCL8
48 funisitis 10.3 IL6 IL1B CXCL8
49 conjunctivochalasis 10.3 IL6 IL1B CXCL8
50 idiopathic neutropenia 10.3 IL6 IL1B

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to Recurrent Corneal Erosion

Symptoms & Phenotypes for Recurrent Corneal Erosion

Drugs & Therapeutics for Recurrent Corneal Erosion

Drugs for Recurrent Corneal Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Lubricant Eye Drops
2 Pharmaceutical Solutions
3 Ophthalmic Solutions
4 Dextrans

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Umbilical Cord Serum Eye Drops Completed NCT01016158 Umbilical cord serum eyedrops
2 Evaluation of the Treatment of Recurrent Corneal Erosions by Anterior Stromal Puncture With Nd: YAG Laser Completed NCT00816738
3 Topical Dehydrex in Treating Recurrent Corneal Erosion Completed NCT00029185 Dehydrex
4 Metalloproteinases and Recurrent Corneal Erosion Syndrome Recruiting NCT02891694
5 Biomarker for Alport Disease - An International, Multi-center, Epidemiological Protocol Recruiting NCT02718027

Search NIH Clinical Center for Recurrent Corneal Erosion

Genetic Tests for Recurrent Corneal Erosion

Anatomical Context for Recurrent Corneal Erosion

MalaCards organs/tissues related to Recurrent Corneal Erosion:

40
Eye, Bone, Liver, Endothelial, Lung, Placenta, Prostate

Publications for Recurrent Corneal Erosion

Articles related to Recurrent Corneal Erosion:

(show top 50) (show all 190)
# Title Authors PMID Year
1
Blood-Based Treatments for Severe Dry Eye Disease: The Need of a Consensus. 61
31533289 2019
2
Recurrent corneal erosion syndrome. 61
30760455 2019
3
Central Toxic Keratopathy After Contact Lens Wear and Mechanical Debridement: Clinical Characteristics, and Visual and Corneal Tomographic Outcomes. 61
31241605 2019
4
Recurrent corneal erosion caused by retained sutures in blepharoplasty. 61
29704130 2019
5
Clinical course and risk factors of recurrent corneal erosion: Observational study. 61
31008925 2019
6
Epithelial map-guided anterior stromal micropuncture for the treatment of recurrent corneal erosion syndrome. 61
29557084 2019
7
[Morphological changes in the cornea of patients with recurrent corneal erosion after diamond burr polishing of Bowman's membrane]. 61
31714509 2019
8
Recurrent corneal erosion: a comprehensive review. 61
30809089 2019
9
Central Toxic Keratopathy After Contact Lens Wear and Mechanical Debridement: Clinical Characteristics, and Visual and Corneal Tomographic Outcomes. 61
30707128 2019
10
Superficial keratectomy: indications and outcomes. 61
30502977 2018
11
Interventions for recurrent corneal erosions. 61
29985545 2018
12
Long-term clinical outcome of femtosecond laser-assisted lamellar keratectomy with phototherapeutic keratectomy in anterior corneal stromal dystrophy. 61
28611133 2018
13
Alcohol delamination of the corneal epithelium for recurrent corneal erosion syndrome. 61
30046528 2018
14
[Polishing of Bowman's membrane with diamond burr in the treatment of recurrent corneal erosion syndrome]. 61
30499512 2018
15
Blood derived eye drops for the treatment of cornea and ocular surface diseases. 61
28844373 2017
16
Comparison of bandage contact lens removal on the fourth versus seventh postoperative day after photorefractive keratectomy: A randomized clinical trial. 61
28626819 2017
17
Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions. 61
28516471 2017
18
Corneal Nerve and Epithelial Cell Alterations in Corneal Allodynia: An In Vivo Confocal Microscopy Case Series. 61
27816571 2017
19
Recurrence rate and subjective symptoms after standardized (Hamburg protocol) phototherapeutic keratectomy on recurrent corneal erosions. 61
27549579 2016
20
[Research progress of corneal epithelial basal cells and basement membrane]. 61
27647251 2016
21
Recurrent corneal erosion syndrome associated with oral isotretinoin: a cautionary tale. 61
26932827 2016
22
Topical Mitomycin-C enhances subbasal nerve regeneration and reduces erosion frequency in the debridement wounded mouse cornea. 61
26332224 2016
23
A COL17A1 Splice-Altering Mutation Is Prevalent in Inherited Recurrent Corneal Erosions. 61
26786512 2016
24
[SEM visualization of corneal epithelium through lanthanoid staining based on Ca/Nd isomorphous substitution in Ca-dependent molecular systems]. 61
28121294 2016
25
Long-Term Outcomes of Epithelial Debridement and Diamond Burr Polishing for Corneal Epithelial Irregularity and Recurrent Corneal Erosion. 61
26203746 2015
26
Phototherapeutic keratectomy (PTK) for treatment of recurrent corneal erosion: Correlation between etiology and prognosis - prospective longitudinal study. 61
25900814 2015
27
Superior Perilimbal Epitheliopathy in Recurrent Corneal Erosion Syndrome. 61
26203756 2015
28
Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions. 61
25129839 2015
29
Autologous serum eye drops for the treatment of ocular surface disease. 61
25603439 2015
30
Genes in dizygote twins with Bowman layer corneal dystrophy. 61
25785536 2015
31
Microbiological study of therapeutic soft contact lenses used in the treatment of recurrent corneal erosion syndrome. 61
25230080 2015
32
Optical coherence tomography findings in recurrent corneal erosion syndrome. 61
25532997 2015
33
[Diabetic eye disease]. 61
25817504 2015
34
Lattice corneal dystrophy type IIIA with hyaline component from a novel A620P mutation and distinct surgical treatments. 61
25321938 2014
35
[Two cases of phototherapeutic keratectomy treatment of the recurrent corneal erosion caused by alkali burn]. 61
25181507 2014
36
Clinical presentation and causes of recurrent corneal erosion syndrome: review of 100 patients. 61
24699561 2014
37
Granular corneal dystrophy: a novel approach to classification and treatment. 61
24413275 2014
38
Anterior stromal puncture for the treatment of recurrent corneal erosion syndrome: patient clinical features and outcomes. 61
24439438 2014
39
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. 61
24352599 2014
40
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. 61
24352600 2014
41
A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. 61
23759442 2014
42
Evaluation of the efficacy of 50% autologous serum eye drops in different ocular surface pathologies. 61
25136628 2014
43
The Effect of Anterior Stromal Puncture Using Q-Switched Nd:YAG Laser on Corneal Wound Healing. 61
25653810 2014
44
Achromobacter xylosoxidans keratitis masquerading as recurrent erosion after LASIK. 61
24063345 2013
45
Lubricants to prevent recurrent corneal erosion: an error in the Cochrane review. 61
23989120 2013
46
Interventions for recurrent corneal erosion: a Cochrane Systematic review. 61
23989116 2013
47
Randomized Controlled Study of Ocular Lubrication Versus Bandage Contact Lens in the Primary Treatment of Recurrent Corneal Erosion Syndrome. 61
23974885 2013
48
Epithelial debridement with diamond burr superficial keratectomy for the treatment of recurrent corneal erosion. 61
23230823 2013
49
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. 61
23132456 2013
50
IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies. 61
23821953 2013

Variations for Recurrent Corneal Erosion

Expression for Recurrent Corneal Erosion

Search GEO for disease gene expression data for Recurrent Corneal Erosion.

Pathways for Recurrent Corneal Erosion

Pathways related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1 11.8 IL6 IL1B CXCL8
2 11.79 IL6 IL1B CXCL8
3 11.76 IL6 IL1B CXCL8
4 11.71 IL6 IL1B CXCL8
5 11.68 IL6 IL1B CXCL8
6 11.65 IL6 IL1B CXCL8
7 11.6 IL6 IL1B CXCL8
8 11.51 IL6 IL1B CXCL8
9 11.46 IL6 IL1B CXCL8
10
Show member pathways
11.3 IL6 IL1B CXCL8
11 11.23 IL6 IL1B CXCL8
12 11.09 IL6 IL1B CXCL8
13 10.84 IL6 CXCL8
14 10.83 IL6 IL1B CXCL8
15 10.67 IL6 IL1B CXCL8 COL8A2 COL17A1
16 10.49 IL6 IL1B CXCL8

GO Terms for Recurrent Corneal Erosion

Cellular components related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 TGFBI IL6 IL1B DNAJC9 CXCL8 COL8A2
2 basement membrane GO:0005604 8.8 TGFBI COL8A2 COL17A1

Biological processes related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of glial cell proliferation GO:0060252 8.96 IL6 IL1B
2 positive regulation of neuroinflammatory response GO:0150078 8.62 IL6 IL1B

Molecular functions related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.8 TGFBI COL8A2 COL17A1

Sources for Recurrent Corneal Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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