MCID: RCR001
MIFTS: 39

Recurrent Corneal Erosion

Categories: Eye diseases

Aliases & Classifications for Recurrent Corneal Erosion

MalaCards integrated aliases for Recurrent Corneal Erosion:

Name: Recurrent Corneal Erosion 12 15
Recurrent Erosion of Cornea 12 73
Recurrent Erosion Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11541
ICD10 33 H18.83
ICD9CM 35 371.42
SNOMED-CT 68 2055003
UMLS 73 C0155119

Summaries for Recurrent Corneal Erosion

MalaCards based summary : Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to epithelial recurrent erosion dystrophy and corneal dystrophy, avellino type. An important gene associated with Recurrent Corneal Erosion is TGFBI (Transforming Growth Factor Beta Induced), and among its related pathways/superpathways are Allograft rejection and Influenza A. The drugs Ophthalmic Solutions and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and brain.

Wikipedia : 76 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea''s... more...

Related Diseases for Recurrent Corneal Erosion

Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Related Disease Score Top Affiliating Genes
1 epithelial recurrent erosion dystrophy 12.0
2 corneal dystrophy, avellino type 11.2
3 corneal dystrophy, lattice type iiia 11.2
4 exudative glomerulonephritis 10.1 CXCL8 IL1B
5 peptic esophagitis 10.1 CXCL8 IL1B
6 haemophilus influenzae 10.1 CXCL8 IL1B
7 opisthorchiasis 10.1 CXCL8 IL1B
8 ascaris lumbricoides infection 10.1 CXCL8 IL1B
9 crohn's colitis 10.1 CXCL8 IL1B
10 dental pulp disease 10.1 CXCL8 IL1B
11 cyclic neutropenia 10.1 CXCL8 IL1B
12 pharyngitis 10.1 CXCL8 IL1B
13 aseptic meningitis 10.1 CXCL8 IL1B
14 wells syndrome 10.1 CXCL8 IL1B
15 gastric ulcer 10.1 CXCL8 IL1B
16 peptic ulcer disease 10.1 CXCL8 IL1B
17 silicosis 10.1 CXCL8 IL1B
18 acute transverse myelitis 10.1 CXCL8 IL6
19 transverse myelitis 10.1 CXCL8 IL6
20 streptococcal toxic-shock syndrome 10.1 CXCL8 IL6
21 denture stomatitis 10.1 CXCL8 IL6
22 papillary conjunctivitis 10.1 CXCL8 IL6
23 conjunctivitis 10.1 CXCL8 IL6
24 acute monoblastic leukemia 10.1 CXCL8 IL6
25 capillary leak syndrome 10.1 CXCL8 IL6
26 atrophic gastritis 10.1 CXCL8 IL1B
27 meconium aspiration syndrome 10.1 CXCL8 IL6
28 gastritis 10.1 CXCL8 IL1B
29 louse-borne relapsing fever 10.1 CXCL8 IL6
30 pyelitis 10.1 CXCL8 IL6
31 necrotizing fasciitis 10.1 CXCL8 IL6
32 fasciitis 10.1 CXCL8 IL6
33 allergic contact dermatitis 10.1 CXCL8 IL1B
34 viral meningitis 10.1 CXCL8 IL6
35 radiculopathy 10.1 CXCL8 IL6
36 helicobacter pylori infection 10.1 CXCL8 IL1B
37 cowpox 10.1 CXCL8 IL6
38 bacteriuria 10.1 CXCL8 IL6
39 pulmonary edema 10.1 CXCL8 IL1B
40 acute cystitis 10.1 CXCL8 IL6
41 cystitis 10.1 CXCL8 IL6
42 duodenal ulcer 10.1 CXCL8 IL1B
43 acute pyelonephritis 10.1 CXCL8 IL6
44 paraneoplastic syndromes 10.1 IL1B IL6
45 periodontitis, chronic 10.1 IL1B IL6
46 lymphadenitis 10.1 CXCL8 IL1B
47 uremic pruritus 10.1 IL1B IL6
48 glossitis 10.1 IL1B IL6
49 hemorrhagic fever with renal syndrome 10.1 CXCL8 IL6
50 laryngitis 10.1 IL1B IL6

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to Recurrent Corneal Erosion

Symptoms & Phenotypes for Recurrent Corneal Erosion

Drugs & Therapeutics for Recurrent Corneal Erosion

Drugs for Recurrent Corneal Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ophthalmic Solutions Phase 4,Not Applicable
2 Pharmaceutical Solutions Not Applicable
3 Lubricant Eye Drops Not Applicable
4 Dextrans Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phototherapeutic Keratectomy (PTK) on Recurrent Corneal Erosions Completed NCT01251692 Phase 4
2 Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy Terminated NCT02373397 Phase 4
3 Evaluation of the Treatment of Recurrent Corneal Erosions by Anterior Stromal Puncture With Nd: YAG Laser Completed NCT00816738
4 Umbilical Cord Serum Eye Drops Completed NCT01016158 Not Applicable Umbilical cord serum eyedrops
5 Study of Dehydrex in Patients With Corneal Erosion Completed NCT00029185 Not Applicable Dehydrex
6 Metalloproteinases and Recurrent Corneal Erosion Syndrome Recruiting NCT02891694

Search NIH Clinical Center for Recurrent Corneal Erosion

Genetic Tests for Recurrent Corneal Erosion

Anatomical Context for Recurrent Corneal Erosion

MalaCards organs/tissues related to Recurrent Corneal Erosion:

41
Eye, Lung, Brain, Bone, Heart, Lymph Node, Spinal Cord

Publications for Recurrent Corneal Erosion

Articles related to Recurrent Corneal Erosion:

(show top 50) (show all 79)
# Title Authors Year
1
Recurrent corneal erosion caused by retained sutures in blepharoplasty. ( 29704130 )
2018
2
Epithelial map-guided anterior stromal micropuncture for the treatment of recurrent corneal erosion syndrome. ( 29557084 )
2018
3
Alcohol delamination of the corneal epithelium for recurrent corneal erosion syndrome. ( 30046528 )
2018
4
Recurrent corneal erosion syndrome associated with oral isotretinoin: a cautionary tale. ( 26932827 )
2016
5
Superior Perilimbal Epitheliopathy in Recurrent Corneal Erosion Syndrome. ( 26203756 )
2015
6
Long-Term Outcomes of Epithelial Debridement and Diamond Burr Polishing for Corneal Epithelial Irregularity and Recurrent Corneal Erosion. ( 26203746 )
2015
7
Optical coherence tomography findings in recurrent corneal erosion syndrome. ( 25532997 )
2015
8
Phototherapeutic keratectomy (PTK) for treatment of recurrent corneal erosion: Correlation between etiology and prognosis - prospective longitudinal study. ( 25900814 )
2015
9
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 24352599 )
2014
10
A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 23759442 )
2014
11
Clinical presentation and causes of recurrent corneal erosion syndrome: review of 100 patients. ( 24699561 )
2014
12
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 24352600 )
2014
13
Microbiological Study of Therapeutic Soft Contact Lenses Used in the Treatment of Recurrent Corneal Erosion Syndrome. ( 25230080 )
2014
14
Anterior stromal puncture for the treatment of recurrent corneal erosion syndrome: patient clinical features and outcomes. ( 24439438 )
2014
15
Interventions for recurrent corneal erosion: a Cochrane Systematic review. ( 23989116 )
2013
16
Lubricants to prevent recurrent corneal erosion: an error in the Cochrane review. ( 23989120 )
2013
17
Randomized Controlled Study of Ocular Lubrication Versus Bandage Contact Lens in the Primary Treatment of Recurrent Corneal Erosion Syndrome. ( 23974885 )
2013
18
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. ( 23132456 )
2013
19
Epithelial debridement with diamond burr superficial keratectomy for the treatment of recurrent corneal erosion. ( 23230823 )
2013
20
IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies. ( 23821953 )
2013
21
Recurrent Corneal Erosion Syndrome. ( 26107728 )
2012
22
Recurrent corneal erosion following uneventful IntraLASIK treated by phototherapeutic keratectomy. ( 22180150 )
2012
23
Franceschetti hereditary recurrent corneal erosion. ( 22402249 )
2012
24
Treatment of recurrent corneal erosion by extended-wear bandage contact lens. ( 20847650 )
2011
25
Alcohol delamination in the treatment of recurrent corneal erosion: an electron microscopic study. ( 20606026 )
2010
26
Recurrent Corneal Erosion Syndrome: A Study of 364 Episodes. ( 20337327 )
2010
27
Induced astigmatism after diamond burr superficial keratectomy for recurrent corneal erosion. ( 19816187 )
2009
28
Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing. ( 19648776 )
2009
29
Recurrent corneal erosion syndrome. ( 19026329 )
2008
30
In vivo biopsy by laser confocal microscopy for evaluation of traumatic recurrent corneal erosion. ( 19093010 )
2008
31
Recurrent corneal erosion syndrome. ( 18191654 )
2008
32
Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid. ( 18290949 )
2008
33
Alcohol delamination of the corneal epithelium for recalcitrant recurrent corneal erosion syndrome: a prospective study of efficacy and safety. ( 17301117 )
2007
34
Reactivation of recurrent corneal erosion syndrome by continuous positive pressure ventilation. ( 18043199 )
2007
35
Upregulation of matrix metalloproteinase in tear fluid of patients with recurrent corneal erosion. ( 17926110 )
2007
36
Small spot phototherapeutic keratectomy for recurrent corneal erosion. ( 17912944 )
2007
37
Recurrent corneal erosion: characteristics and management options. ( 18306941 )
2007
38
Recurrent corneal erosion. ( 17908600 )
2007
39
The cleavage plane of corneal epithelial adhesion complex in traumatic recurrent corneal erosion. ( 16604052 )
2006
40
Long-term efficacy of phototherapeutic keratectomy on recurrent corneal erosion syndrome. ( 17172888 )
2006
41
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. ( 15721675 )
2005
42
Recurrent corneal erosion (RCE) secondary to lattice dystrophy in a patient with acquired immune deficiency syndrome (AIDS). ( 16361033 )
2005
43
Treatment of recurrent corneal erosion with substance P-derived peptide and insulin-like growth factor I. ( 16219742 )
2005
44
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. ( 15030848 )
2004
45
Successful management of three consecutive cases of recurrent corneal erosion with botulinum toxin injections. ( 14765101 )
2004
46
Observation of tear film in recurrent corneal erosion and epithelial basement membrane dystrophy. ( 12613981 )
2002
47
Phototherapeutic keratectomy re-treatment for recurrent corneal erosion syndrome. ( 11864879 )
2002
48
Recurrent corneal erosion after laser in situ keratomileusis. ( 11248819 )
2001
49
Phototherapeutic keratectomy for treatment of recurrent corneal erosion. ( 10609204 )
1999
50
Matrix metalloproteinases in epithelia from human recurrent corneal erosion. ( 10235563 )
1999

Variations for Recurrent Corneal Erosion

Expression for Recurrent Corneal Erosion

Search GEO for disease gene expression data for Recurrent Corneal Erosion.

Pathways for Recurrent Corneal Erosion

Pathways related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 CXCL8 IL1B IL6
2
Show member pathways
12.54 CXCL8 IL1B IL6
3
Show member pathways
12.51 CXCL8 IL1B IL6
4
Show member pathways
12.09 CXCL8 IL1B IL6
5
Show member pathways
12.06 CXCL8 IL1B IL6
6
Show member pathways
12.02 CXCL8 IL1B IL6
7
Show member pathways
11.98 CXCL8 IL1B IL6
8
Show member pathways
11.94 CXCL8 IL1B IL6
9 11.92 CXCL8 IL1B IL6
10
Show member pathways
11.83 CXCL8 IL1B IL6
11 11.78 CXCL8 IL1B IL6
12 11.74 CXCL8 IL1B IL6
13 11.7 CXCL8 IL1B IL6
14 11.68 IL1B IL6
15 11.67 CXCL8 IL1B
16
Show member pathways
11.66 CXCL8 IL6
17 11.65 CXCL8 IL1B IL6
18 11.62 CXCL8 IL1B IL6
19 11.6 CXCL8 IL6
20 11.56 CXCL8 IL1B IL6
21 11.55 IL1B IL6
22 11.53 IL1B IL6
23 11.51 CXCL8 IL1B IL6
24 11.48 CXCL8 IL6
25 11.43 CXCL8 IL1B IL6
26 11.4 CXCL8 IL6
27 11.37 CXCL8 IL6
28 11.34 IL1B IL6
29 11.32 CXCL8 IL6
30 11.3 IL1B IL6
31 11.3 CXCL8 IL1B IL6
32
Show member pathways
11.23 CXCL8 IL1B IL6
33 11.18 IL1B IL6
34 11.17 IL1B IL6
35 11.17 IL1B IL6
36 11.15 CXCL8 IL6
37 11.12 IL1B IL6
38 11.1 IL1B IL6
39 11.07 CXCL8 IL1B IL6
40 11.06 IL1B IL6
41 10.97 CXCL8 IL1B IL6
42 10.85 CXCL8 IL6
43 10.82 CXCL8 IL1B IL6
44 10.76 CXCL8 IL1B IL6
45 10.49 CXCL8 IL1B IL6

GO Terms for Recurrent Corneal Erosion

Cellular components related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CXCL8 DNAJC9 IL1B IL6 TGFBI

Biological processes related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.71 CXCL8 IL1B IL6
2 regulation of signaling receptor activity GO:0010469 9.65 CXCL8 IL1B IL6
3 negative regulation of cell proliferation GO:0008285 9.63 CXCL8 IL1B IL6
4 inflammatory response GO:0006954 9.58 CXCL8 IL1B IL6
5 neutrophil chemotaxis GO:0030593 9.55 CXCL8 IL1B
6 cytokine-mediated signaling pathway GO:0019221 9.54 CXCL8 IL1B IL6
7 response to glucocorticoid GO:0051384 9.52 IL1B IL6
8 positive regulation of T cell proliferation GO:0042102 9.51 IL1B IL6
9 positive regulation of interleukin-6 production GO:0032755 9.49 IL1B IL6
10 social behavior GO:0035176 9.43 DNAJC9 IL1B
11 negative regulation of neurogenesis GO:0050768 9.32 IL1B IL6
12 positive regulation of neutrophil chemotaxis GO:0090023 9.26 CXCL8 IL1B
13 positive regulation of glial cell proliferation GO:0060252 9.16 IL1B IL6
14 cellular response to lipopolysaccharide GO:0071222 9.13 CXCL8 IL1B IL6
15 positive regulation of neuroinflammatory response GO:0150078 8.62 IL1B IL6

Molecular functions related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL1B IL6

Sources for Recurrent Corneal Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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