MCID: RCR001
MIFTS: 39

Recurrent Corneal Erosion

Categories: Eye diseases

Aliases & Classifications for Recurrent Corneal Erosion

MalaCards integrated aliases for Recurrent Corneal Erosion:

Name: Recurrent Corneal Erosion 12 15
Recurrent Erosion of Cornea 12 74
Recurrent Erosion Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11541
ICD9CM 36 371.42
SNOMED-CT 69 2055003
ICD10 34 H18.83
UMLS 74 C0155119

Summaries for Recurrent Corneal Erosion

MalaCards based summary : Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to acquired immunodeficiency syndrome and epithelial recurrent erosion dystrophy. An important gene associated with Recurrent Corneal Erosion is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Allograft rejection and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. The drugs Ophthalmic Solutions and Lubricant Eye Drops have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and bone.

Wikipedia : 77 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea''s... more...

Related Diseases for Recurrent Corneal Erosion

Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
# Related Disease Score Top Affiliating Genes
1 acquired immunodeficiency syndrome 29.7 IL1B IL6
2 epithelial recurrent erosion dystrophy 12.1
3 corneal dystrophy, avellino type 11.2
4 corneal dystrophy, lattice type iiia 11.2
5 exudative glomerulonephritis 10.2 CXCL8 IL1B
6 peptic esophagitis 10.2 CXCL8 IL1B
7 haemophilus influenzae 10.2 CXCL8 IL1B
8 opisthorchiasis 10.2 CXCL8 IL1B
9 crohn's colitis 10.2 CXCL8 IL1B
10 gastritis 10.2 CXCL8 IL1B
11 dental pulp disease 10.2 CXCL8 IL1B
12 pharyngitis 10.2 CXCL8 IL1B
13 aseptic meningitis 10.2 CXCL8 IL1B
14 wells syndrome 10.2 CXCL8 IL1B
15 gastric ulcer 10.1 CXCL8 IL1B
16 peptic ulcer disease 10.1 CXCL8 IL1B
17 acute transverse myelitis 10.1 CXCL8 IL6
18 transverse myelitis 10.1 CXCL8 IL6
19 streptococcal toxic-shock syndrome 10.1 CXCL8 IL6
20 denture stomatitis 10.1 CXCL8 IL6
21 silicosis 10.1 CXCL8 IL1B
22 papillary conjunctivitis 10.1 CXCL8 IL6
23 conjunctivitis 10.1 CXCL8 IL6
24 acute monoblastic leukemia 10.1 CXCL8 IL6
25 capillary leak syndrome 10.1 CXCL8 IL6
26 meconium aspiration syndrome 10.1 CXCL8 IL6
27 louse-borne relapsing fever 10.1 CXCL8 IL6
28 atrophic gastritis 10.1 CXCL8 IL1B
29 pyelitis 10.1 CXCL8 IL6
30 necrotizing fasciitis 10.1 CXCL8 IL6
31 fasciitis 10.1 CXCL8 IL6
32 allergic contact dermatitis 10.1 CXCL8 IL1B
33 viral meningitis 10.1 CXCL8 IL6
34 radiculopathy 10.1 CXCL8 IL6
35 cowpox 10.1 CXCL8 IL6
36 helicobacter pylori infection 10.1 CXCL8 IL1B
37 bacteriuria 10.1 CXCL8 IL6
38 pulmonary edema 10.1 CXCL8 IL1B
39 acute cystitis 10.1 CXCL8 IL6
40 cystitis 10.1 CXCL8 IL6
41 duodenal ulcer 10.1 CXCL8 IL1B
42 acute pyelonephritis 10.1 CXCL8 IL6
43 periodontitis, chronic 10.1 IL1B IL6
44 uremic pruritus 10.1 IL1B IL6
45 glossitis 10.1 IL1B IL6
46 laryngitis 10.1 IL1B IL6
47 euthyroid sick syndrome 10.1 IL1B IL6
48 acute vascular insufficiency of intestine 10.1 IL1B IL6
49 hemorrhagic fever with renal syndrome 10.1 CXCL8 IL6
50 lymphadenitis 10.1 CXCL8 IL1B

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to Recurrent Corneal Erosion

Symptoms & Phenotypes for Recurrent Corneal Erosion

Drugs & Therapeutics for Recurrent Corneal Erosion

Drugs for Recurrent Corneal Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ophthalmic Solutions Phase 4,Not Applicable
2 Lubricant Eye Drops Not Applicable
3 Pharmaceutical Solutions Not Applicable
4 Dextrans Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phototherapeutic Keratectomy (PTK) on Recurrent Corneal Erosions Completed NCT01251692 Phase 4
2 Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy Terminated NCT02373397 Phase 4
3 Evaluation of the Treatment of Recurrent Corneal Erosions by Anterior Stromal Puncture With Nd: YAG Laser Completed NCT00816738
4 Umbilical Cord Serum Eye Drops Completed NCT01016158 Not Applicable Umbilical cord serum eyedrops
5 Study of Dehydrex in Patients With Corneal Erosion Completed NCT00029185 Not Applicable Dehydrex
6 Metalloproteinases and Recurrent Corneal Erosion Syndrome Recruiting NCT02891694

Search NIH Clinical Center for Recurrent Corneal Erosion

Genetic Tests for Recurrent Corneal Erosion

Anatomical Context for Recurrent Corneal Erosion

MalaCards organs/tissues related to Recurrent Corneal Erosion:

42
Eye, Brain, Bone, Heart, Lymph Node, Spinal Cord, Placenta

Publications for Recurrent Corneal Erosion

Articles related to Recurrent Corneal Erosion:

(show top 50) (show all 82)
# Title Authors Year
1
Epithelial map-guided anterior stromal micropuncture for the treatment of recurrent corneal erosion syndrome. ( 29557084 )
2019
2
Recurrent corneal erosion syndrome. ( 30760455 )
2019
3
Recurrent corneal erosion: a comprehensive review. ( 30809089 )
2019
4
Clinical course and risk factors of recurrent corneal erosion: Observational study. ( 31008925 )
2019
5
Recurrent corneal erosion caused by retained sutures in blepharoplasty. ( 29704130 )
2018
6
Alcohol delamination of the corneal epithelium for recurrent corneal erosion syndrome. ( 30046528 )
2018
7
Recurrent corneal erosion syndrome associated with oral isotretinoin: a cautionary tale. ( 26932827 )
2016
8
Microbiological study of therapeutic soft contact lenses used in the treatment of recurrent corneal erosion syndrome. ( 25230080 )
2015
9
Optical coherence tomography findings in recurrent corneal erosion syndrome. ( 25532997 )
2015
10
Phototherapeutic keratectomy (PTK) for treatment of recurrent corneal erosion: Correlation between etiology and prognosis - prospective longitudinal study. ( 25900814 )
2015
11
Long-Term Outcomes of Epithelial Debridement and Diamond Burr Polishing for Corneal Epithelial Irregularity and Recurrent Corneal Erosion. ( 26203746 )
2015
12
Superior Perilimbal Epitheliopathy in Recurrent Corneal Erosion Syndrome. ( 26203756 )
2015
13
A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 23759442 )
2014
14
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 24352599 )
2014
15
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 24352600 )
2014
16
Anterior stromal puncture for the treatment of recurrent corneal erosion syndrome: patient clinical features and outcomes. ( 24439438 )
2014
17
Clinical presentation and causes of recurrent corneal erosion syndrome: review of 100 patients. ( 24699561 )
2014
18
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. ( 23132456 )
2013
19
Epithelial debridement with diamond burr superficial keratectomy for the treatment of recurrent corneal erosion. ( 23230823 )
2013
20
IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies. ( 23821953 )
2013
21
Randomized Controlled Study of Ocular Lubrication Versus Bandage Contact Lens in the Primary Treatment of Recurrent Corneal Erosion Syndrome. ( 23974885 )
2013
22
Interventions for recurrent corneal erosion: a Cochrane Systematic review. ( 23989116 )
2013
23
Lubricants to prevent recurrent corneal erosion: an error in the Cochrane review. ( 23989120 )
2013
24
Recurrent corneal erosion following uneventful IntraLASIK treated by phototherapeutic keratectomy. ( 22180150 )
2012
25
Franceschetti hereditary recurrent corneal erosion. ( 22402249 )
2012
26
Recurrent Corneal Erosion Syndrome. ( 26107728 )
2012
27
Treatment of recurrent corneal erosion by extended-wear bandage contact lens. ( 20847650 )
2011
28
Recurrent Corneal Erosion Syndrome: A Study of 364 Episodes. ( 20337327 )
2010
29
Alcohol delamination in the treatment of recurrent corneal erosion: an electron microscopic study. ( 20606026 )
2010
30
Induced astigmatism after diamond burr superficial keratectomy for recurrent corneal erosion. ( 19816187 )
2009
31
Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing. ( 19648776 )
2009
32
Recurrent corneal erosion syndrome. ( 18191654 )
2008
33
Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid. ( 18290949 )
2008
34
Recurrent corneal erosion syndrome. ( 19026329 )
2008
35
In vivo biopsy by laser confocal microscopy for evaluation of traumatic recurrent corneal erosion. ( 19093010 )
2008
36
Alcohol delamination of the corneal epithelium for recalcitrant recurrent corneal erosion syndrome: a prospective study of efficacy and safety. ( 17301117 )
2007
37
Recurrent corneal erosion. ( 17908600 )
2007
38
Small spot phototherapeutic keratectomy for recurrent corneal erosion. ( 17912944 )
2007
39
Upregulation of matrix metalloproteinase in tear fluid of patients with recurrent corneal erosion. ( 17926110 )
2007
40
Reactivation of recurrent corneal erosion syndrome by continuous positive pressure ventilation. ( 18043199 )
2007
41
Recurrent corneal erosion: characteristics and management options. ( 18306941 )
2007
42
The cleavage plane of corneal epithelial adhesion complex in traumatic recurrent corneal erosion. ( 16604052 )
2006
43
Long-term efficacy of phototherapeutic keratectomy on recurrent corneal erosion syndrome. ( 17172888 )
2006
44
Treatment of recurrent corneal erosion with substance P-derived peptide and insulin-like growth factor I. ( 16219742 )
2005
45
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. ( 15721675 )
2005
46
Recurrent corneal erosion (RCE) secondary to lattice dystrophy in a patient with acquired immune deficiency syndrome (AIDS). ( 16361033 )
2005
47
Successful management of three consecutive cases of recurrent corneal erosion with botulinum toxin injections. ( 14765101 )
2004
48
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. ( 15030848 )
2004
49
Observation of tear film in recurrent corneal erosion and epithelial basement membrane dystrophy. ( 12613981 )
2002
50
Phototherapeutic keratectomy re-treatment for recurrent corneal erosion syndrome. ( 11864879 )
2002

Variations for Recurrent Corneal Erosion

Expression for Recurrent Corneal Erosion

Search GEO for disease gene expression data for Recurrent Corneal Erosion.

Pathways for Recurrent Corneal Erosion

Pathways related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.6 CXCL8 IL1B IL6
2
Show member pathways
12.51 CXCL8 IL1B IL6
3
Show member pathways
12.09 CXCL8 IL1B IL6
4
Show member pathways
12.06 CXCL8 IL1B IL6
5
Show member pathways
12.02 CXCL8 IL1B IL6
6
Show member pathways
11.98 CXCL8 IL1B IL6
7
Show member pathways
11.94 CXCL8 IL1B IL6
8 11.92 CXCL8 IL1B IL6
9
Show member pathways
11.83 CXCL8 IL1B IL6
10 11.78 CXCL8 IL1B IL6
11 11.74 CXCL8 IL1B IL6
12 11.7 CXCL8 IL1B IL6
13 11.69 CXCL8 IL1B
14 11.68 IL1B IL6
15
Show member pathways
11.65 CXCL8 IL6
16 11.65 CXCL8 IL1B IL6
17 11.62 CXCL8 IL1B IL6
18 11.6 CXCL8 IL6
19 11.57 CXCL8 IL1B IL6
20 11.54 IL1B IL6
21 11.52 IL1B IL6
22 11.51 CXCL8 IL1B IL6
23 11.48 CXCL8 IL6
24 11.43 CXCL8 IL1B IL6
25 11.4 CXCL8 IL6
26 11.37 CXCL8 IL6
27 11.34 IL1B IL6
28 11.32 CXCL8 IL6
29 11.3 IL1B IL6
30 11.3 CXCL8 IL1B IL6
31
Show member pathways
11.23 CXCL8 IL1B IL6
32 11.2 IL1B IL6
33 11.17 IL1B IL6
34 11.17 IL1B IL6
35 11.15 CXCL8 IL6
36 11.12 IL1B IL6
37 11.1 IL1B IL6
38 11.07 CXCL8 IL1B IL6
39 11.06 IL1B IL6
40 10.97 CXCL8 IL1B IL6
41 10.85 CXCL8 IL6
42 10.82 CXCL8 IL1B IL6
43 10.76 CXCL8 IL1B IL6
44 10.49 CXCL8 IL1B IL6

GO Terms for Recurrent Corneal Erosion

Cellular components related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CXCL8 DNAJC9 IL1B IL6 TGFBI

Biological processes related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.71 CXCL8 IL1B IL6
2 regulation of signaling receptor activity GO:0010469 9.65 CXCL8 IL1B IL6
3 negative regulation of cell proliferation GO:0008285 9.63 CXCL8 IL1B IL6
4 inflammatory response GO:0006954 9.58 CXCL8 IL1B IL6
5 neutrophil chemotaxis GO:0030593 9.55 CXCL8 IL1B
6 cytokine-mediated signaling pathway GO:0019221 9.54 CXCL8 IL1B IL6
7 positive regulation of T cell proliferation GO:0042102 9.51 IL1B IL6
8 positive regulation of interleukin-6 production GO:0032755 9.49 IL1B IL6
9 negative regulation of neurogenesis GO:0050768 9.32 IL1B IL6
10 response to glucocorticoid GO:0051384 9.22 IL6
11 positive regulation of glial cell proliferation GO:0060252 9.16 IL1B IL6
12 social behavior GO:0035176 9.13 DNAJC9
13 cellular response to lipopolysaccharide GO:0071222 9.13 CXCL8 IL1B IL6
14 positive regulation of neutrophil chemotaxis GO:0090023 8.96 CXCL8
15 positive regulation of neuroinflammatory response GO:0150078 8.62 IL1B IL6

Molecular functions related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL1B IL6

Sources for Recurrent Corneal Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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