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MCID: RCR001
MIFTS: 34

Recurrent Corneal Erosion

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Recurrent Corneal Erosion

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MalaCards integrated aliases for Recurrent Corneal Erosion:

Name: Recurrent Corneal Erosion 12 15
Recurrent Erosion of Cornea 12 72
Recurrent Erosion Syndrome 12

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:11541
ICD9CM 35 371.42
SNOMED-CT 68 2055003
ICD10 33 H18.83
UMLS 72 C0155119
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Summaries for Recurrent Corneal Erosion

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MalaCards based summary : Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to conjunctivitis and keratoconjunctivitis sicca. An important gene associated with Recurrent Corneal Erosion is TGFBI (Transforming Growth Factor Beta Induced), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Toll Comparative Pathway. The drugs Ophthalmic Solutions and Lubricant Eye Drops have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 75 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea's... more...

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Related Diseases for Recurrent Corneal Erosion

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Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 conjunctivitis 30.5 IL6 CXCL8
2 keratoconjunctivitis sicca 30.3 IL6 IL1B
3 corneal edema 30.3 IL1B COL8A2
4 corneal dystrophy 30.0 TGFBI COL8A2 COL17A1
5 epithelial basement membrane dystrophy 29.8 TGFBI COL8A2 COL17A1
6 corneal disease 29.6 TGFBI COL8A2
7 epithelial recurrent erosion dystrophy 12.2
8 corneal dystrophy, lattice type i 11.3
9 corneal dystrophy, avellino type 11.3
10 corneal dystrophy, reis-bucklers type 11.3
11 corneal dystrophy, lattice type iiia 11.3
12 lattice corneal dystrophy type ii 11.3
13 exudative glomerulonephritis 10.5 IL1B CXCL8
14 peptic esophagitis 10.5 IL1B CXCL8
15 haemophilus influenzae 10.5 IL1B CXCL8
16 opisthorchiasis 10.5 IL1B CXCL8
17 crohn's colitis 10.5 IL1B CXCL8
18 dental pulp disease 10.5 IL1B CXCL8
19 streptococcal toxic-shock syndrome 10.4 IL6 CXCL8
20 acute transverse myelitis 10.4 IL6 CXCL8
21 transverse myelitis 10.4 IL6 CXCL8
22 papillary conjunctivitis 10.4 IL6 CXCL8
23 denture stomatitis 10.4 IL6 CXCL8
24 pharyngitis 10.4 IL1B CXCL8
25 aseptic meningitis 10.4 IL1B CXCL8
26 acute monoblastic leukemia 10.4 IL6 CXCL8
27 keratitis, hereditary 10.4
28 capillary leak syndrome 10.4 IL6 CXCL8
29 wells syndrome 10.4 IL1B CXCL8
30 meconium aspiration syndrome 10.4 IL6 CXCL8
31 louse-borne relapsing fever 10.4 IL6 CXCL8
32 pyelitis 10.4 IL6 CXCL8
33 necrotizing fasciitis 10.4 IL6 CXCL8
34 periodontitis, chronic 10.4 IL6 IL1B
35 fasciitis 10.4 IL6 CXCL8
36 uremic pruritus 10.4 IL6 IL1B
37 cowpox 10.4 IL6 CXCL8
38 laryngitis 10.4 IL6 IL1B
39 radiculopathy 10.4 IL6 CXCL8
40 glossitis 10.4 IL6 IL1B
41 viral meningitis 10.4 IL6 CXCL8
42 bacteriuria 10.4 IL6 CXCL8
43 acute vascular insufficiency of intestine 10.4 IL6 IL1B
44 euthyroid sick syndrome 10.4 IL6 IL1B
45 osteosclerotic myeloma 10.4 IL6 IL1B
46 ascaris lumbricoides infection 10.4 IL6 IL1B
47 periapical periodontitis 10.4 IL6 IL1B
48 poems syndrome 10.4 IL6 IL1B
49 stachybotrys chartarum 10.4 IL6 IL1B
50 gastric ulcer 10.4 IL1B CXCL8

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to Recurrent Corneal Erosion
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Symptoms & Phenotypes for Recurrent Corneal Erosion

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Drugs & Therapeutics for Recurrent Corneal Erosion

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Drugs for Recurrent Corneal Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ophthalmic Solutions
2 Lubricant Eye Drops
3 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Umbilical Cord Serum Eye Drops Completed NCT01016158 Umbilical cord serum eyedrops
2 Evaluation of the Treatment of Recurrent Corneal Erosions by Anterior Stromal Puncture With Nd: YAG Laser Completed NCT00816738
3 Metalloproteinases and Recurrent Corneal Erosion Syndrome Recruiting NCT02891694
4 Biomarker for Alport Disease - An International, Multi-center, Epidemiological Protocol Recruiting NCT02718027

Search NIH Clinical Center for Recurrent Corneal Erosion

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Genetic Tests for Recurrent Corneal Erosion

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Anatomical Context for Recurrent Corneal Erosion

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MalaCards organs/tissues related to Recurrent Corneal Erosion:

41
Eye
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Publications for Recurrent Corneal Erosion

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Articles related to Recurrent Corneal Erosion:

(show top 50) (show all 188)
# Title Authors PMID Year
1
Central Toxic Keratopathy After Contact Lens Wear and Mechanical Debridement: Clinical Characteristics, and Visual and Corneal Tomographic Outcomes. 38
31241605 2019
2
Recurrent corneal erosion caused by retained sutures in blepharoplasty. 38
29704130 2019
3
Clinical course and risk factors of recurrent corneal erosion: Observational study. 38
31008925 2019
4
Epithelial map-guided anterior stromal micropuncture for the treatment of recurrent corneal erosion syndrome. 38
29557084 2019
5
Recurrent corneal erosion syndrome. 38
30760455 2019
6
Central Toxic Keratopathy After Contact Lens Wear and Mechanical Debridement: Clinical Characteristics, and Visual and Corneal Tomographic Outcomes. 38
30707128 2019
7
Recurrent corneal erosion: a comprehensive review. 38
30809089 2019
8
Superficial keratectomy: indications and outcomes. 38
30502977 2018
9
Interventions for recurrent corneal erosions. 38
29985545 2018
10
Long-term clinical outcome of femtosecond laser-assisted lamellar keratectomy with phototherapeutic keratectomy in anterior corneal stromal dystrophy. 38
28611133 2018
11
Alcohol delamination of the corneal epithelium for recurrent corneal erosion syndrome. 38
30046528 2018
12
[Polishing of Bowman's membrane with diamond burr in the treatment of recurrent corneal erosion syndrome]. 38
30499512 2018
13
Blood derived eye drops for the treatment of cornea and ocular surface diseases. 38
28844373 2017
14
Comparison of bandage contact lens removal on the fourth versus seventh postoperative day after photorefractive keratectomy: A randomized clinical trial. 38
28626819 2017
15
Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions. 38
28516471 2017
16
Corneal Nerve and Epithelial Cell Alterations in Corneal Allodynia: An In Vivo Confocal Microscopy Case Series. 38
27816571 2017
17
Recurrence rate and subjective symptoms after standardized (Hamburg protocol) phototherapeutic keratectomy on recurrent corneal erosions. 38
27549579 2016
18
[Research progress of corneal epithelial basal cells and basement membrane]. 38
27647251 2016
19
Recurrent corneal erosion syndrome associated with oral isotretinoin: a cautionary tale. 38
26932827 2016
20
Topical Mitomycin-C enhances subbasal nerve regeneration and reduces erosion frequency in the debridement wounded mouse cornea. 38
26332224 2016
21
A COL17A1 Splice-Altering Mutation Is Prevalent in Inherited Recurrent Corneal Erosions. 38
26786512 2016
22
[SEM visualization of corneal epithelium through lanthanoid staining based on Ca/Nd isomorphous substitution in Ca-dependent molecular systems]. 38
28121294 2016
23
Long-Term Outcomes of Epithelial Debridement and Diamond Burr Polishing for Corneal Epithelial Irregularity and Recurrent Corneal Erosion. 38
26203746 2015
24
Phototherapeutic keratectomy (PTK) for treatment of recurrent corneal erosion: Correlation between etiology and prognosis - prospective longitudinal study. 38
25900814 2015
25
Superior Perilimbal Epitheliopathy in Recurrent Corneal Erosion Syndrome. 38
26203756 2015
26
Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions. 38
25129839 2015
27
Autologous serum eye drops for the treatment of ocular surface disease. 38
25603439 2015
28
Genes in dizygote twins with Bowman layer corneal dystrophy. 38
25785536 2015
29
Microbiological study of therapeutic soft contact lenses used in the treatment of recurrent corneal erosion syndrome. 38
25230080 2015
30
Optical coherence tomography findings in recurrent corneal erosion syndrome. 38
25532997 2015
31
[Diabetic eye disease]. 38
25817504 2015
32
Lattice corneal dystrophy type IIIA with hyaline component from a novel A620P mutation and distinct surgical treatments. 38
25321938 2014
33
[Two cases of phototherapeutic keratectomy treatment of the recurrent corneal erosion caused by alkali burn]. 38
25181507 2014
34
Clinical presentation and causes of recurrent corneal erosion syndrome: review of 100 patients. 38
24699561 2014
35
Granular corneal dystrophy: a novel approach to classification and treatment. 38
24413275 2014
36
Anterior stromal puncture for the treatment of recurrent corneal erosion syndrome: patient clinical features and outcomes. 38
24439438 2014
37
A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. 38
23759442 2014
38
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. 38
24352599 2014
39
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. 38
24352600 2014
40
The Effect of Anterior Stromal Puncture Using Q-Switched Nd:YAG Laser on Corneal Wound Healing. 38
25653810 2014
41
Evaluation of the efficacy of 50% autologous serum eye drops in different ocular surface pathologies. 38
25136628 2014
42
Achromobacter xylosoxidans keratitis masquerading as recurrent erosion after LASIK. 38
24063345 2013
43
Lubricants to prevent recurrent corneal erosion: an error in the Cochrane review. 38
23989120 2013
44
Interventions for recurrent corneal erosion: a Cochrane Systematic review. 38
23989116 2013
45
Randomized Controlled Study of Ocular Lubrication Versus Bandage Contact Lens in the Primary Treatment of Recurrent Corneal Erosion Syndrome. 38
23974885 2013
46
Epithelial debridement with diamond burr superficial keratectomy for the treatment of recurrent corneal erosion. 38
23230823 2013
47
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. 38
23132456 2013
48
IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies. 38
23821953 2013
49
Haemophilus influenza endophthalmitis after pterygium surgery. 38
21912259 2013
50
Metalloproteinases in corneal diseases: degradation and processing. 38
23038036 2012
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Variations for Recurrent Corneal Erosion

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Expression for Recurrent Corneal Erosion

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Search GEO for disease gene expression data for Recurrent Corneal Erosion.
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Pathways for Recurrent Corneal Erosion

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Pathways related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
IL-17 Family Signaling Pathways 65
Show member pathways
 12.11 IL6 IL1B CXCL8
2
Toll Comparative Pathway 64
Show member pathways
 12.09 IL6 IL1B CXCL8
3
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.04 IL6 IL1B CXCL8
4
IL-1 Family Signaling Pathways 65
Show member pathways
 12 IL6 IL1B CXCL8
5
Bacterial infections in CF airways 22
Show member pathways
 11.96 IL6 IL1B CXCL8
6
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 11.95 IL1B CXCL8 COL8A2 COL17A1
7
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.94 IL6 IL1B CXCL8
8
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.86 IL6 IL1B CXCL8
9
Spinal Cord Injury 1
11.79 IL6 IL1B CXCL8
10
Interleukin-4 and 13 signaling 66
11.76 IL6 IL1B CXCL8
11
Senescence and Autophagy in Cancer 1
11.71 IL6 IL1B CXCL8
12
AGE-RAGE signaling pathway in diabetic complications 37
11.67 IL6 IL1B CXCL8
13
Amoebiasis 37
11.66 IL6 IL1B CXCL8
14
Rheumatoid arthritis 37
11.6 IL6 IL1B CXCL8
15
Salmonella infection (KEGG) 37
11.52 IL6 IL1B CXCL8
16
LPA receptor mediated events 1
11.49 IL6 CXCL8
17
Pertussis 37
11.46 IL6 IL1B CXCL8
18
ATF-2 transcription factor network 1
11.41 IL6 CXCL8
19
Hepatitis C and Hepatocellular Carcinoma 1
11.37 IL6 CXCL8
20
Hematopoietic Stem Cell Differentiation 1
11.34 IL6 IL1B
21
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.34 IL6 IL1B CXCL8
22
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.32 IL6 CXCL8
23
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.3 IL6 IL1B
24
Lung fibrosis 1
11.3 IL6 IL1B CXCL8
25
African trypanosomiasis 37
11.2 IL6 IL1B
26
Prion diseases 37
11.19 IL6 IL1B
27
IL-10 Pathway 64
11.18 IL6 IL1B
28
Legionellosis 37
11.18 IL6 IL1B CXCL8
29
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.16 IL6 CXCL8
30
Development and heterogeneity of the ILC family 1
11.13 IL6 IL1B
31
Antifolate resistance 37
11.1 IL6 IL1B
32
Cytokines and Inflammatory Response 1
11.07 IL6 IL1B
33
Malaria 37
11.02 IL6 IL1B CXCL8
34
G-protein signaling_RhoB regulation pathway 22
11 IL6 IL1B CXCL8
35
Overview of nanoparticle effects 1
10.86 IL6 CXCL8
36
Interleukin-10 signaling 66
10.82 IL6 IL1B CXCL8
37
G-protein signaling_Rap2B regulation pathway 22
9.92 IL6 IL1B CXCL8 COL8A2 COL17A1
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GO Terms for Recurrent Corneal Erosion

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Cellular components related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 TGFBI IL6 IL1B CXCL8 COL8A2 COL17A1
2 extracellular matrix GO:0031012 9.54 TGFBI COL8A2 COL17A1
3 endoplasmic reticulum lumen GO:0005788 9.5 IL6 COL8A2 COL17A1
4 collagen-containing extracellular matrix GO:0062023 9.43 TGFBI COL8A2 COL17A1
5 extracellular space GO:0005615 9.17 TGFBI IL6 IL1B DNAJC9 CXCL8 COL8A2
6 basement membrane GO:0005604 9.13 TGFBI COL8A2 COL17A1

Biological processes related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.63 IL6 IL1B CXCL8
2 cytokine-mediated signaling pathway GO:0019221 9.61 IL6 IL1B CXCL8
3 angiogenesis GO:0001525 9.58 TGFBI CXCL8 COL8A2
4 extracellular matrix organization GO:0030198 9.5 TGFBI COL8A2 COL17A1
5 positive regulation of T cell proliferation GO:0042102 9.49 IL6 IL1B
6 positive regulation of interleukin-6 production GO:0032755 9.48 IL6 IL1B
7 negative regulation of neurogenesis GO:0050768 9.37 IL6 IL1B
8 cellular response to lipopolysaccharide GO:0071222 9.33 IL6 IL1B CXCL8
9 positive regulation of neutrophil chemotaxis GO:0090023 8.96 CXCL8
10 positive regulation of glial cell proliferation GO:0060252 8.96 IL6 IL1B
11 positive regulation of neuroinflammatory response GO:0150078 8.62 IL6 IL1B

Molecular functions related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.16 COL8A2 COL17A1
2 cytokine activity GO:0005125 9.13 IL6 IL1B CXCL8
3 extracellular matrix structural constituent GO:0005201 8.8 TGFBI COL8A2 COL17A1
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Sources for Recurrent Corneal Erosion

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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