MCID: RCR001
MIFTS: 31

Recurrent Corneal Erosion

Categories: Neuronal diseases

Aliases & Classifications for Recurrent Corneal Erosion

MalaCards integrated aliases for Recurrent Corneal Erosion:

Name: Recurrent Corneal Erosion 12 15
Recurrent Erosion of Cornea 12 71
Recurrent Erosion Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11541
ICD9CM 34 371.42
SNOMED-CT 67 2055003
ICD10 32 H18.83
UMLS 71 C0155119

Summaries for Recurrent Corneal Erosion

MalaCards based summary : Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to epithelial recurrent erosion dystrophy and corneal dystrophy, subepithelial mucinous. An important gene associated with Recurrent Corneal Erosion is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Bacterial infections in CF airways and Spinal Cord Injury. The drugs Pharmaceutical Solutions and Ophthalmic Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 74 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea's... more...

Related Diseases for Recurrent Corneal Erosion

Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 288)
# Related Disease Score Top Affiliating Genes
1 epithelial recurrent erosion dystrophy 33.3 TGFBI DNAJC9 COL17A1
2 corneal dystrophy, subepithelial mucinous 32.4 TBCD KRT12
3 corneal dystrophy, groenouw type i 31.8 TGFBI TBCD KRT12 CHST6
4 corneal dystrophy, reis-bucklers type 31.4 TGFBI TBCD KRT3 KRT12 CHST6
5 corneal dystrophy, avellino type 31.0 TGFBI TBCD KRT3 KRT12 COL8A2 CHST6
6 keratitis, hereditary 31.0 KRT3 IL6 IL1B
7 epithelial basement membrane dystrophy 30.2 TGFBI TBCD COL8A2 CHST6
8 corneal edema 30.2 KRT3 IL1B COL8A2
9 irregular astigmatism 29.8 TGFBI KRT3 KRT12 COL8A2
10 lattice corneal dystrophy 29.8 TGFBI TBCD KRT12 CHST6
11 corneal ulcer 29.7 KRT3 IL1B FN1
12 stromal dystrophy 29.2 TGFBI TBCD KRT3 KRT12 COL8A2 CHST6
13 corneal dystrophy 29.1 TGFBI TBCD KRT3 KRT12 COL8A2 COL17A1
14 granular corneal dystrophy 28.9 TGFBI TBCD KRT3 KRT12 COL8A2 CHST6
15 eye disease 28.7 TGFBI IL6 IL1B FN1 CXCL8 COL8A2
16 keratoconus 28.6 TGFBI KRT3 KRT12 IL6 IL1B FN1
17 corneal disease 27.8 TGFBI KRT3 KRT12 IL6 IL1B FN1
18 corneal dystrophy, lattice type i 11.3
19 corneal dystrophy, lattice type iiia 11.3
20 lattice corneal dystrophy type ii 11.3
21 prosthetic joint infection 10.5 IL6 IL1B
22 periodontitis, chronic 10.5 IL6 IL1B
23 idiopathic anterior uveitis 10.5 IL6 CXCL8
24 bagassosis 10.5 IL1B CXCL8
25 streptococcal toxic-shock syndrome 10.5 IL6 CXCL8
26 acute transverse myelitis 10.5 IL6 CXCL8
27 transverse myelitis 10.5 IL6 CXCL8
28 uremic pruritus 10.5 IL6 IL1B
29 indolent myeloma 10.5 IL6 IL1B
30 anaerobic pneumonia 10.5 IL6 IL1B
31 glomeruloid hemangioma 10.5 IL6 IL1B
32 photokeratitis 10.5 IL6 IL1B
33 fuchs' heterochromic uveitis 10.4 IL6 CXCL8
34 stachybotrys chartarum 10.4 IL6 IL1B
35 suppurative periapical periodontitis 10.4 IL6 IL1B
36 eales disease 10.4 IL6 IL1B
37 carbuncle 10.4 IL6 IL1B
38 chemical colitis 10.4 IL6 IL1B
39 pseudopterygium 10.4 KRT3 KRT12
40 aortitis 10.4 IL6 IL1B
41 bacterial conjunctivitis 10.4 IL1B CXCL8
42 pneumonic tularemia 10.4 IL6 IL1B
43 acute monoblastic leukemia 10.4 IL6 CXCL8
44 lung abscess 10.4 IL6 IL1B
45 denture stomatitis 10.4 IL6 CXCL8
46 pyuria 10.3 IL6 CXCL8
47 chlamydia pneumonia 10.3 IL6 IL1B CXCL8
48 chlamydia 10.3 IL6 IL1B CXCL8
49 progressive myoclonus epilepsy 8 10.3 IL6 CXCL8
50 peptic esophagitis 10.3 IL6 IL1B CXCL8

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to Recurrent Corneal Erosion

Symptoms & Phenotypes for Recurrent Corneal Erosion

Drugs & Therapeutics for Recurrent Corneal Erosion

Drugs for Recurrent Corneal Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions
2 Ophthalmic Solutions
3 Lubricant Eye Drops
4 Dextrans

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Umbilical Cord Serum Eye Drops Completed NCT01016158 Umbilical cord serum eyedrops
2 Evaluation of the Treatment of Recurrent Corneal Erosions by Anterior Stromal Puncture With Nd: YAG Laser Completed NCT00816738
3 Topical Dehydrex in Treating Recurrent Corneal Erosion Completed NCT00029185 Dehydrex
4 Metalloproteinases and Recurrent Corneal Erosion Syndrome Recruiting NCT02891694

Search NIH Clinical Center for Recurrent Corneal Erosion

Genetic Tests for Recurrent Corneal Erosion

Anatomical Context for Recurrent Corneal Erosion

MalaCards organs/tissues related to Recurrent Corneal Erosion:

40
Eye

Publications for Recurrent Corneal Erosion

Articles related to Recurrent Corneal Erosion:

(show top 50) (show all 192)
# Title Authors PMID Year
1
Risk of recurrent corneal erosion in patients with diabetes mellitus in Taiwan: a population-based cohort study. 61
32565466 2020
2
Corneal Sensitivity and Tear Function in Recurrent Corneal Erosion Syndrome. 61
32181797 2020
3
Recurrent corneal erosion syndrome. 61
30760455 2019
4
Blood-Based Treatments for Severe Dry Eye Disease: The Need of a Consensus. 61
31533289 2019
5
Central Toxic Keratopathy After Contact Lens Wear and Mechanical Debridement: Clinical Characteristics, and Visual and Corneal Tomographic Outcomes. 61
31241605 2019
6
Recurrent corneal erosion caused by retained sutures in blepharoplasty. 61
29704130 2019
7
Epithelial map-guided anterior stromal micropuncture for the treatment of recurrent corneal erosion syndrome. 61
29557084 2019
8
Clinical course and risk factors of recurrent corneal erosion: Observational study. 61
31008925 2019
9
Central Toxic Keratopathy After Contact Lens Wear and Mechanical Debridement: Clinical Characteristics, and Visual and Corneal Tomographic Outcomes. 61
30707128 2019
10
Recurrent corneal erosion: a comprehensive review. 61
30809089 2019
11
[Morphological changes in the cornea of patients with recurrent corneal erosion after diamond burr polishing of Bowman's membrane]. 61
31714509 2019
12
Superficial keratectomy: indications and outcomes. 61
30502977 2018
13
Interventions for recurrent corneal erosions. 61
29985545 2018
14
Long-term clinical outcome of femtosecond laser-assisted lamellar keratectomy with phototherapeutic keratectomy in anterior corneal stromal dystrophy. 61
28611133 2018
15
Alcohol delamination of the corneal epithelium for recurrent corneal erosion syndrome. 61
30046528 2018
16
[Polishing of Bowman's membrane with diamond burr in the treatment of recurrent corneal erosion syndrome]. 61
30499512 2018
17
Blood derived eye drops for the treatment of cornea and ocular surface diseases. 61
28844373 2017
18
Comparison of bandage contact lens removal on the fourth versus seventh postoperative day after photorefractive keratectomy: A randomized clinical trial. 61
28626819 2017
19
Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions. 61
28516471 2017
20
Corneal Nerve and Epithelial Cell Alterations in Corneal Allodynia: An In Vivo Confocal Microscopy Case Series. 61
27816571 2017
21
Recurrence rate and subjective symptoms after standardized (Hamburg protocol) phototherapeutic keratectomy on recurrent corneal erosions. 61
27549579 2016
22
[Research progress of corneal epithelial basal cells and basement membrane]. 61
27647251 2016
23
Recurrent corneal erosion syndrome associated with oral isotretinoin: a cautionary tale. 61
26932827 2016
24
Topical Mitomycin-C enhances subbasal nerve regeneration and reduces erosion frequency in the debridement wounded mouse cornea. 61
26332224 2016
25
A COL17A1 Splice-Altering Mutation Is Prevalent in Inherited Recurrent Corneal Erosions. 61
26786512 2016
26
[SEM visualization of corneal epithelium through lanthanoid staining based on Ca/Nd isomorphous substitution in Ca-dependent molecular systems]. 61
28121294 2016
27
Long-Term Outcomes of Epithelial Debridement and Diamond Burr Polishing for Corneal Epithelial Irregularity and Recurrent Corneal Erosion. 61
26203746 2015
28
Phototherapeutic keratectomy (PTK) for treatment of recurrent corneal erosion: Correlation between etiology and prognosis - prospective longitudinal study. 61
25900814 2015
29
Superior Perilimbal Epitheliopathy in Recurrent Corneal Erosion Syndrome. 61
26203756 2015
30
Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions. 61
25129839 2015
31
Autologous serum eye drops for the treatment of ocular surface disease. 61
25603439 2015
32
Genes in dizygote twins with Bowman layer corneal dystrophy. 61
25785536 2015
33
Microbiological study of therapeutic soft contact lenses used in the treatment of recurrent corneal erosion syndrome. 61
25230080 2015
34
Optical coherence tomography findings in recurrent corneal erosion syndrome. 61
25532997 2015
35
[Diabetic eye disease]. 61
25817504 2015
36
Lattice corneal dystrophy type IIIA with hyaline component from a novel A620P mutation and distinct surgical treatments. 61
25321938 2014
37
[Two cases of phototherapeutic keratectomy treatment of the recurrent corneal erosion caused by alkali burn]. 61
25181507 2014
38
Clinical presentation and causes of recurrent corneal erosion syndrome: review of 100 patients. 61
24699561 2014
39
Granular corneal dystrophy: a novel approach to classification and treatment. 61
24413275 2014
40
Anterior stromal puncture for the treatment of recurrent corneal erosion syndrome: patient clinical features and outcomes. 61
24439438 2014
41
A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. 61
23759442 2014
42
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. 61
24352599 2014
43
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. 61
24352600 2014
44
The Effect of Anterior Stromal Puncture Using Q-Switched Nd:YAG Laser on Corneal Wound Healing. 61
25653810 2014
45
Evaluation of the efficacy of 50% autologous serum eye drops in different ocular surface pathologies. 61
25136628 2014
46
Achromobacter xylosoxidans keratitis masquerading as recurrent erosion after LASIK. 61
24063345 2013
47
Lubricants to prevent recurrent corneal erosion: an error in the Cochrane review. 61
23989120 2013
48
Interventions for recurrent corneal erosion: a Cochrane Systematic review. 61
23989116 2013
49
Randomized Controlled Study of Ocular Lubrication Versus Bandage Contact Lens in the Primary Treatment of Recurrent Corneal Erosion Syndrome. 61
23974885 2013
50
Epithelial debridement with diamond burr superficial keratectomy for the treatment of recurrent corneal erosion. 61
23230823 2013

Variations for Recurrent Corneal Erosion

Expression for Recurrent Corneal Erosion

Search GEO for disease gene expression data for Recurrent Corneal Erosion.

Pathways for Recurrent Corneal Erosion

Pathways related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.95 IL6 IL1B FN1 CXCL8
2 11.82 IL6 IL1B CXCL8
3 11.78 IL6 IL1B FN1 CXCL8
4 11.73 IL6 IL1B FN1 CXCL8
5 11.69 IL6 IL1B CXCL8
6 11.65 IL6 IL1B FN1 CXCL8
7 11.59 IL6 IL1B CXCL8
8
Show member pathways
11.5 IL6 IL1B CXCL8
9 11.49 IL6 IL1B CXCL8
10 11.47 IL6 IL1B FN1 CXCL8
11 11.43 IL6 IL1B CXCL8
12 11.35 IL6 IL1B CXCL8
13 11.32 IL6 IL1B CXCL8
14 11.26 IL6 IL1B FN1 CXCL8
15 10.64 IL6 IL1B
16 10.64 IL6 IL1B FN1 CXCL8 COL8A2 COL17A1
17 10.08 IL6 FN1 CXCL8

GO Terms for Recurrent Corneal Erosion

Cellular components related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.62 TGFBI FN1 COL8A2 COL17A1
2 endoplasmic reticulum lumen GO:0005788 9.56 IL6 FN1 COL8A2 COL17A1
3 extracellular space GO:0005615 9.56 TGFBI IL6 IL1B FN1 DNAJC9 CXCL8
4 extracellular matrix GO:0031012 9.46 TGFBI FN1 COL8A2 COL17A1
5 basement membrane GO:0005604 8.92 TGFBI FN1 COL8A2 COL17A1

Biological processes related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.46 IL6 IL1B FN1 CXCL8
2 positive regulation of glial cell proliferation GO:0060252 9.32 IL6 IL1B
3 positive regulation of neuroinflammatory response GO:0150078 9.26 IL6 IL1B
4 angiogenesis GO:0001525 9.26 TGFBI FN1 CXCL8 COL8A2
5 extracellular matrix organization GO:0030198 8.92 TGFBI FN1 COL8A2 COL17A1

Molecular functions related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.13 TGFBI IL1B FN1
2 extracellular matrix structural constituent GO:0005201 8.92 TGFBI FN1 COL8A2 COL17A1

Sources for Recurrent Corneal Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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