MCID: RCR001
MIFTS: 37

Recurrent Corneal Erosion

Categories: Eye diseases

Aliases & Classifications for Recurrent Corneal Erosion

MalaCards integrated aliases for Recurrent Corneal Erosion:

Name: Recurrent Corneal Erosion 12 15
Recurrent Erosion of Cornea 12 73
Recurrent Erosion Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11541
ICD10 33 H18.83
ICD9CM 35 371.42
UMLS 73 C0155119

Summaries for Recurrent Corneal Erosion

MalaCards based summary : Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to corneal edema and epithelial recurrent erosion dystrophy. An important gene associated with Recurrent Corneal Erosion is TGFBI (Transforming Growth Factor Beta Induced), and among its related pathways/superpathways are Influenza A and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. The drugs Ophthalmic Solutions and Tetrahydrozoline have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 76 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea\'s... more...

Related Diseases for Recurrent Corneal Erosion

Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 corneal edema 29.6 IL1B TGFBI
2 epithelial recurrent erosion dystrophy 11.8
3 corneal dystrophy, avellino type 11.1
4 corneal dystrophy, lattice type iiia 11.1
5 periodontitis, chronic 10.4 IL1B IL6
6 uremic pruritus 10.4 IL1B IL6
7 glossitis 10.4 IL1B IL6
8 euthyroid sick syndrome 10.4 IL1B IL6
9 laryngitis 10.4 IL1B IL6
10 ascaris lumbricoides infection 10.4 IL1B IL6
11 acute vascular insufficiency of intestine 10.4 IL1B IL6
12 poems syndrome 10.4 IL1B IL6
13 periapical periodontitis 10.4 IL1B IL6
14 central nervous system vasculitis 10.4 IL1B IL6
15 osteosclerotic myeloma 10.4 IL1B IL6
16 stachybotrys chartarum 10.4 IL1B IL6
17 cysticercosis 10.4 IL1B IL6
18 primary amebic meningoencephalitis 10.4 IL1B IL6
19 hydrarthrosis 10.4 IL1B IL6
20 eales disease 10.4 IL1B IL6
21 endometritis 10.4 IL1B IL6
22 joint disorders 10.4 IL1B IL6
23 gingival disease 10.4 IL1B IL6
24 commensal bacterial infectious disease 10.4 IL1B IL6
25 lacrimal apparatus disease 10.4 IL1B IL6
26 adult-onset still's disease 10.4 IL1B IL6
27 aphthous stomatitis 10.4 IL1B IL6
28 dengue shock syndrome 10.3 IL1B IL6
29 extrinsic cardiomyopathy 10.3 IL1B IL6
30 complex regional pain syndrome 10.3 IL1B IL6
31 idiopathic neutropenia 10.3 IL1B IL6
32 chikungunya 10.3 IL1B IL6
33 keratoconjunctivitis sicca 10.3 IL1B IL6
34 pericarditis 10.3 IL1B IL6
35 typhoid fever 10.3 IL1B IL6
36 carpal tunnel syndrome 10.3 IL1B IL6
37 acute transverse myelitis 10.3 CXCL8 IL6
38 lyme disease 10.3 IL1B IL6
39 streptococcal toxic-shock syndrome 10.3 CXCL8 IL6
40 denture stomatitis 10.3 CXCL8 IL6
41 papillary conjunctivitis 10.3 CXCL8 IL6
42 acute monoblastic leukemia 10.3 CXCL8 IL6
43 capillary leak syndrome 10.3 CXCL8 IL6
44 meconium aspiration syndrome 10.3 CXCL8 IL6
45 intervertebral disc disease 10.3 IL1B IL6
46 louse-borne relapsing fever 10.3 CXCL8 IL6
47 preterm premature rupture of the membranes 10.3 CXCL8 IL6
48 transverse myelitis 10.3 CXCL8 IL6
49 necrotizing fasciitis 10.3 CXCL8 IL6
50 bacteriuria 10.3 CXCL8 IL6

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to Recurrent Corneal Erosion

Symptoms & Phenotypes for Recurrent Corneal Erosion

Drugs & Therapeutics for Recurrent Corneal Erosion

Drugs for Recurrent Corneal Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ophthalmic Solutions Phase 4,Not Applicable
2 Tetrahydrozoline Phase 4,Not Applicable
3
Ephedrine Approved Not Applicable 299-42-3 9294
4
Pseudoephedrine Approved Not Applicable 90-82-4 7028
5 Autonomic Agents Not Applicable
6 Lubricant Eye Drops Not Applicable
7 Nasal Decongestants Not Applicable
8 Peripheral Nervous System Agents Not Applicable
9 Pharmaceutical Solutions Not Applicable
10 Respiratory System Agents Not Applicable
11 Vasoconstrictor Agents Not Applicable
12 Dextrans Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phototherapeutic Keratectomy (PTK) on Recurrent Corneal Erosions Completed NCT01251692 Phase 4
2 Cacicol20® in Corneal Wound Healing and Nerve Regeneration After Phototherapeutic Keratectomy Terminated NCT02373397 Phase 4
3 Evaluation of the Treatment of Recurrent Corneal Erosions by Anterior Stromal Puncture With Nd: YAG Laser Completed NCT00816738
4 Umbilical Cord Serum Eye Drops Completed NCT01016158 Not Applicable Umbilical cord serum eyedrops
5 Study of Dehydrex in Patients With Corneal Erosion Completed NCT00029185 Not Applicable Dehydrex
6 Metalloproteinases and Recurrent Corneal Erosion Syndrome Recruiting NCT02891694

Search NIH Clinical Center for Recurrent Corneal Erosion

Genetic Tests for Recurrent Corneal Erosion

Anatomical Context for Recurrent Corneal Erosion

MalaCards organs/tissues related to Recurrent Corneal Erosion:

41
Eye

Publications for Recurrent Corneal Erosion

Articles related to Recurrent Corneal Erosion:

(show top 50) (show all 81)
# Title Authors Year
1
Recurrent corneal erosion caused by retained sutures in blepharoplasty. ( 29704130 )
2018
2
Epithelial map-guided anterior stromal micropuncture for the treatment of recurrent corneal erosion syndrome. ( 29557084 )
2018
3
Recurrent corneal erosion syndrome associated with oral isotretinoin: a cautionary tale. ( 26932827 )
2016
4
A COL17A1 Splice-Altering Mutation Is Prevalent in Inherited Recurrent Corneal Erosions. ( 26786512 )
2016
5
Superior Perilimbal Epitheliopathy in Recurrent Corneal Erosion Syndrome. ( 26203756 )
2015
6
Long-Term Outcomes of Epithelial Debridement and Diamond Burr Polishing for Corneal Epithelial Irregularity and Recurrent Corneal Erosion. ( 26203746 )
2015
7
Optical coherence tomography findings in recurrent corneal erosion syndrome. ( 25532997 )
2015
8
Phototherapeutic keratectomy (PTK) for treatment of recurrent corneal erosion: Correlation between etiology and prognosis - prospective longitudinal study. ( 25900814 )
2015
9
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 24352599 )
2014
10
A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 23759442 )
2014
11
Clinical presentation and causes of recurrent corneal erosion syndrome: review of 100 patients. ( 24699561 )
2014
12
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. ( 24352600 )
2014
13
Microbiological Study of Therapeutic Soft Contact Lenses Used in the Treatment of Recurrent Corneal Erosion Syndrome. ( 25230080 )
2014
14
Anterior stromal puncture for the treatment of recurrent corneal erosion syndrome: patient clinical features and outcomes. ( 24439438 )
2014
15
Interventions for recurrent corneal erosion: a Cochrane Systematic review. ( 23989116 )
2013
16
Lubricants to prevent recurrent corneal erosion: an error in the Cochrane review. ( 23989120 )
2013
17
Randomized Controlled Study of Ocular Lubrication Versus Bandage Contact Lens in the Primary Treatment of Recurrent Corneal Erosion Syndrome. ( 23974885 )
2013
18
Changes of clinical manifestation of granular corneal deposits because of recurrent corneal erosion in granular corneal dystrophy types 1 and 2. ( 23132456 )
2013
19
Epithelial debridement with diamond burr superficial keratectomy for the treatment of recurrent corneal erosion. ( 23230823 )
2013
20
IL1beta, IL6 and IL8 gene polymorphisms involvement in recurrent corneal erosion in patients with hereditary stromal corneal dystrophies. ( 23821953 )
2013
21
Recurrent Corneal Erosion Syndrome. ( 26107728 )
2012
22
Recurrent corneal erosion following uneventful IntraLASIK treated by phototherapeutic keratectomy. ( 22180150 )
2012
23
Franceschetti hereditary recurrent corneal erosion. ( 22402249 )
2012
24
Treatment of recurrent corneal erosion by extended-wear bandage contact lens. ( 20847650 )
2011
25
Alcohol delamination in the treatment of recurrent corneal erosion: an electron microscopic study. ( 20606026 )
2010
26
Recurrent Corneal Erosion Syndrome: A Study of 364 Episodes. ( 20337327 )
2010
27
Recurrent corneal erosions and epithelial basement membrane dystrophy. ( 20724847 )
2010
28
Induced astigmatism after diamond burr superficial keratectomy for recurrent corneal erosion. ( 19816187 )
2009
29
Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing. ( 19648776 )
2009
30
Recurrent corneal erosion syndrome. ( 19026329 )
2008
31
In vivo biopsy by laser confocal microscopy for evaluation of traumatic recurrent corneal erosion. ( 19093010 )
2008
32
Recurrent corneal erosion syndrome. ( 18191654 )
2008
33
Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid. ( 18290949 )
2008
34
Alcohol delamination of the corneal epithelium for recalcitrant recurrent corneal erosion syndrome: a prospective study of efficacy and safety. ( 17301117 )
2007
35
Reactivation of recurrent corneal erosion syndrome by continuous positive pressure ventilation. ( 18043199 )
2007
36
Upregulation of matrix metalloproteinase in tear fluid of patients with recurrent corneal erosion. ( 17926110 )
2007
37
Small spot phototherapeutic keratectomy for recurrent corneal erosion. ( 17912944 )
2007
38
Recurrent corneal erosion: characteristics and management options. ( 18306941 )
2007
39
Recurrent corneal erosion. ( 17908600 )
2007
40
The cleavage plane of corneal epithelial adhesion complex in traumatic recurrent corneal erosion. ( 16604052 )
2006
41
Long-term efficacy of phototherapeutic keratectomy on recurrent corneal erosion syndrome. ( 17172888 )
2006
42
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. ( 15721675 )
2005
43
Recurrent corneal erosion (RCE) secondary to lattice dystrophy in a patient with acquired immune deficiency syndrome (AIDS). ( 16361033 )
2005
44
Treatment of recurrent corneal erosion with substance P-derived peptide and insulin-like growth factor I. ( 16219742 )
2005
45
Anterior stromal puncture for recurrent corneal erosion after laser in situ keratomileusis. ( 15030848 )
2004
46
Anterior basement membrane corneal dystrophy and pseudo-unilateral lattice corneal dystrophy in a patient with recurrent corneal erosions. ( 15183802 )
2004
47
Successful management of three consecutive cases of recurrent corneal erosion with botulinum toxin injections. ( 14765101 )
2004
48
Observation of tear film in recurrent corneal erosion and epithelial basement membrane dystrophy. ( 12613981 )
2002
49
Phototherapeutic keratectomy re-treatment for recurrent corneal erosion syndrome. ( 11864879 )
2002
50
Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. ( 11438047 )
2001

Variations for Recurrent Corneal Erosion

Expression for Recurrent Corneal Erosion

Search GEO for disease gene expression data for Recurrent Corneal Erosion.

Pathways for Recurrent Corneal Erosion

Pathways related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 CXCL8 IL1B IL6
2
Show member pathways
12.5 CXCL8 IL1B IL6
3
Show member pathways
12.38 CXCL8 IL1B IL6
4
Show member pathways
12.09 CXCL8 IL1B IL6
5
Show member pathways
12.03 CXCL8 IL1B IL6
6
Show member pathways
11.99 CXCL8 IL1B IL6
7
Show member pathways
11.94 CXCL8 IL1B IL6
8 11.92 CXCL8 IL1B IL6
9
Show member pathways
11.83 CXCL8 IL1B IL6
10 11.78 CXCL8 IL1B IL6
11 11.74 CXCL8 IL1B IL6
12 11.7 CXCL8 IL1B IL6
13 11.67 IL1B IL6
14 11.66 CXCL8 IL1B
15
Show member pathways
11.65 CXCL8 IL6
16 11.65 CXCL8 IL1B IL6
17 11.62 CXCL8 IL1B IL6
18 11.59 CXCL8 IL6
19 11.56 CXCL8 IL1B IL6
20 11.54 IL1B IL6
21 11.51 CXCL8 IL1B IL6
22 11.48 CXCL8 IL6
23 11.43 CXCL8 IL1B IL6
24 11.4 CXCL8 IL6
25 11.36 CXCL8 IL6
26 11.33 IL1B IL6
27 11.32 CXCL8 IL6
28 11.3 CXCL8 IL1B IL6
29 11.29 IL1B IL6
30
Show member pathways
11.23 CXCL8 IL1B IL6
31 11.18 IL1B IL6
32 11.17 IL1B IL6
33 11.17 IL1B IL6
34 11.15 CXCL8 IL6
35 11.11 IL1B IL6
36 11.09 IL1B IL6
37 11.07 IL1B IL6
38 11.07 CXCL8 IL1B IL6
39 10.85 CXCL8 IL6
40 10.82 CXCL8 IL1B IL6
41 10.49 CXCL8 IL1B IL6

GO Terms for Recurrent Corneal Erosion

Cellular components related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CXCL8 DNAJC9 IL1B IL6 TGFBI

Biological processes related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.63 CXCL8 IL1B IL6
2 regulation of signaling receptor activity GO:0010469 9.54 CXCL8 IL1B IL6
3 negative regulation of cell proliferation GO:0008285 9.5 CXCL8 IL1B IL6
4 neutrophil chemotaxis GO:0030593 9.43 CXCL8 IL1B
5 inflammatory response GO:0006954 9.43 CXCL8 IL1B IL6
6 positive regulation of T cell proliferation GO:0042102 9.4 IL1B IL6
7 positive regulation of interleukin-6 production GO:0032755 9.16 IL1B IL6
8 cytokine-mediated signaling pathway GO:0019221 9.13 CXCL8 IL1B IL6
9 positive regulation of leukocyte chemotaxis GO:0002690 8.62 CXCL8 IL6

Molecular functions related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CXCL8 IL1B IL6

Sources for Recurrent Corneal Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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