MCID: RCR001
MIFTS: 33

Recurrent Corneal Erosion

Categories: Neuronal diseases

Aliases & Classifications for Recurrent Corneal Erosion

MalaCards integrated aliases for Recurrent Corneal Erosion:

Name: Recurrent Corneal Erosion 12 15
Recurrent Erosion of Cornea 12 71
Recurrent Erosion Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11541
ICD9CM 34 371.42
SNOMED-CT 67 2055003
ICD10 32 H18.83
UMLS 71 C0155119

Summaries for Recurrent Corneal Erosion

MalaCards based summary : Recurrent Corneal Erosion, also known as recurrent erosion of cornea, is related to epithelial recurrent erosion dystrophy and keratitis, hereditary. An important gene associated with Recurrent Corneal Erosion is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Bacterial infections in CF airways and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Ophthalmic Solutions and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include eye.

Wikipedia : 74 Recurrent corneal erosion is a disorder of the eyes characterized by the failure of the cornea's... more...

Related Diseases for Recurrent Corneal Erosion

Diseases related to Recurrent Corneal Erosion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 331)
# Related Disease Score Top Affiliating Genes
1 epithelial recurrent erosion dystrophy 31.6 TGFBI DNMBP DNAJC9 COL17A1
2 keratitis, hereditary 30.7 KRT3 IL6 IL1B CXCL8
3 epithelial basement membrane dystrophy 30.4 TGFBI KRT3 KRT12 CHST6
4 acne 30.3 IL6 IL1B CXCL8
5 lattice corneal dystrophy 30.0 TGFBI KRT3 KRT12 CHST6
6 irregular astigmatism 29.9 TGFBI KRT3 KRT12 COL8A2
7 keratopathy 29.8 TAC1 KRT12 CXCL8
8 granular corneal dystrophy 29.6 TGFBI KRT3 KRT12 COL8A2 CHST6
9 stromal dystrophy 29.6 TGFBI KRT3 KRT12 COL8A2 CHST6
10 corneal dystrophy 29.5 TGFBI KRT3 KRT12 FN1 COL8A2 COL17A1
11 corneal edema 29.5 TGFBI KRT3 IL1B FN1 COL8A2
12 corneal ulcer 29.4 TAC1 KRT3 IL1B FN1
13 keratoconus 29.0 TGFBI KRT3 KRT12 IL6 IL1B FN1
14 corneal disease 28.0 TGFBI TAC1 KRT3 KRT12 IL6 IL1B
15 corneal dystrophy, lattice type iiia 11.2
16 physiological polycythemia 10.4 IL6 IL1B
17 enterocolitis 10.4 IL6 CXCL8
18 prosthetic joint infection 10.4 IL6 IL1B
19 periodontitis, chronic 10.4 IL6 IL1B
20 idiopathic anterior uveitis 10.4 IL6 CXCL8
21 uremic pruritus 10.4 IL6 IL1B
22 indolent plasma cell myeloma 10.4 IL6 IL1B
23 streptococcal toxic-shock syndrome 10.4 IL6 CXCL8
24 acute transverse myelitis 10.4 IL6 CXCL8
25 back pain 10.4 IL6 IL1B
26 anaerobic pneumonia 10.4 IL6 IL1B
27 ulcer of lower limbs 10.4 IL6 IL1B
28 acute pericementitis 10.4 IL1B CXCL8
29 transient arthritis 10.4 IL6 IL1B
30 acute gonococcal cervicitis 10.4 IL6 CXCL8
31 fuchs' heterochromic uveitis 10.4 IL6 CXCL8
32 glomeruloid hemangioma 10.3 IL6 IL1B
33 stachybotrys chartarum 10.3 IL6 IL1B
34 carbuncle 10.3 IL6 IL1B
35 baritosis 10.3 IL1B CXCL8
36 hypopyon 10.3 IL6 IL1B
37 eales disease 10.3 IL6 IL1B
38 tenosynovitis 10.3 IL6 IL1B
39 aortitis 10.3 IL6 IL1B
40 acute monoblastic leukemia 10.3 IL6 CXCL8
41 lung abscess 10.3 IL6 IL1B
42 traumatic brain injury 10.3 IL6 IL1B
43 denture stomatitis 10.3 IL6 CXCL8
44 progressive myoclonus epilepsy 8 10.3 IL6 CXCL8
45 scleral disease 10.3 IL6 IL1B
46 pyuria 10.3 IL6 CXCL8
47 tungiasis 10.3 IL1B CXCL8
48 laryngitis 10.3 IL6 IL1B
49 pemphigoid 10.3 IL1B COL17A1
50 suppurative periapical periodontitis 10.3 IL6 IL1B CXCL8

Graphical network of the top 20 diseases related to Recurrent Corneal Erosion:



Diseases related to Recurrent Corneal Erosion

Symptoms & Phenotypes for Recurrent Corneal Erosion

Drugs & Therapeutics for Recurrent Corneal Erosion

Drugs for Recurrent Corneal Erosion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Ophthalmic Solutions
2 Pharmaceutical Solutions
3 Lubricant Eye Drops
4 Dextrans

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ten-year Results of Phototherapeutic Keratectomy on Recurrent Corneal Erosions Completed NCT01251692 Phase 4
2 Umbilical Cord Serum Eye Drops Completed NCT01016158 Umbilical cord serum eyedrops
3 Evaluation of the Treatment of Recurrent Corneal Erosions by Anterior Stromal Puncture With Nd: YAG Laser Completed NCT00816738
4 Metalloproteinases and Recurrent Corneal Erosion Syndrome Completed NCT02891694
5 Topical Dehydrex in Treating Recurrent Corneal Erosion Completed NCT00029185 Dehydrex

Search NIH Clinical Center for Recurrent Corneal Erosion

Genetic Tests for Recurrent Corneal Erosion

Anatomical Context for Recurrent Corneal Erosion

MalaCards organs/tissues related to Recurrent Corneal Erosion:

40
Eye

Publications for Recurrent Corneal Erosion

Articles related to Recurrent Corneal Erosion:

(show top 50) (show all 201)
# Title Authors PMID Year
1
Review on the Use of Topical Ocular Hypertonic Saline in Corneal Edema. 61
33470681 2021
2
Myopic outcomes after excimer laser phototherapeutic keratectomy (PTK). 61
33158609 2021
3
Eye pain in the white and quiet eye. 61
33009080 2020
4
Galectin-3, IL-1A, IL-6, and EGF Levels in Corneal Epithelium of Patients With Recurrent Corneal Erosion Syndrome. 61
32732704 2020
5
Cataract incision-related corneal erosion: recurrent corneal erosion because of clear corneal cataract surgery. 61
32818355 2020
6
Contact lens induced bacterial keratitis in LCD II: Management and multimodal imaging: a case report and review of literature. 61
33124478 2020
7
Eye pain in the white and quiet eye. 61
32897919 2020
8
Combined Phototherapeutic Keratectomy and Peripheral Anterior Stromal Puncture for the Treatment of Recurrent Corneal Erosion Syndrome. 61
32783422 2020
9
Recurrent corneal erosion image by scanning electron microscopy. 61
32709814 2020
10
Risk of recurrent corneal erosion in patients with diabetes mellitus in Taiwan: a population-based cohort study. 61
32565466 2020
11
Corneal Sensitivity and Tear Function in Recurrent Corneal Erosion Syndrome. 61
32181797 2020
12
[Recurrent corneal erosion: modern view of the problem]. 61
33063983 2020
13
Bandage Contact Lenses versus Deproteinized Calf Blood Extract Eye Gel for Recurrent Corneal Erosion Syndrome: A Case-Control Study. 61
33223832 2020
14
Blood-Based Treatments for Severe Dry Eye Disease: The Need of a Consensus. 61
31533289 2019
15
Recurrent corneal erosion syndrome. 61
30760455 2019
16
Central Toxic Keratopathy After Contact Lens Wear and Mechanical Debridement: Clinical Characteristics, and Visual and Corneal Tomographic Outcomes. 61
31241605 2019
17
Recurrent corneal erosion caused by retained sutures in blepharoplasty. 61
29704130 2019
18
Epithelial map-guided anterior stromal micropuncture for the treatment of recurrent corneal erosion syndrome. 61
29557084 2019
19
Clinical course and risk factors of recurrent corneal erosion: Observational study. 61
31008925 2019
20
[Morphological changes in the cornea of patients with recurrent corneal erosion after diamond burr polishing of Bowman's membrane]. 61
31714509 2019
21
Recurrent corneal erosion: a comprehensive review. 61
30809089 2019
22
Superficial keratectomy: indications and outcomes. 61
30502977 2018
23
Interventions for recurrent corneal erosions. 61
29985545 2018
24
Alcohol delamination of the corneal epithelium for recurrent corneal erosion syndrome. 61
30046528 2018
25
Long-term clinical outcome of femtosecond laser-assisted lamellar keratectomy with phototherapeutic keratectomy in anterior corneal stromal dystrophy. 61
28611133 2018
26
[Polishing of Bowman's membrane with diamond burr in the treatment of recurrent corneal erosion syndrome]. 61
30499512 2018
27
Blood derived eye drops for the treatment of cornea and ocular surface diseases. 61
28844373 2017
28
Comparison of bandage contact lens removal on the fourth versus seventh postoperative day after photorefractive keratectomy: A randomized clinical trial. 61
28626819 2017
29
Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions. 61
28516471 2017
30
Corneal Nerve and Epithelial Cell Alterations in Corneal Allodynia: An In Vivo Confocal Microscopy Case Series. 61
27816571 2017
31
Recurrence rate and subjective symptoms after standardized (Hamburg protocol) phototherapeutic keratectomy on recurrent corneal erosions. 61
27549579 2016
32
[Research progress of corneal epithelial basal cells and basement membrane]. 61
27647251 2016
33
Recurrent corneal erosion syndrome associated with oral isotretinoin: a cautionary tale. 61
26932827 2016
34
Topical Mitomycin-C enhances subbasal nerve regeneration and reduces erosion frequency in the debridement wounded mouse cornea. 61
26332224 2016
35
A COL17A1 Splice-Altering Mutation Is Prevalent in Inherited Recurrent Corneal Erosions. 61
26786512 2016
36
[SEM visualization of corneal epithelium through lanthanoid staining based on Ca/Nd isomorphous substitution in Ca-dependent molecular systems]. 61
28121294 2016
37
Phototherapeutic keratectomy (PTK) for treatment of recurrent corneal erosion: Correlation between etiology and prognosis - prospective longitudinal study. 61
25900814 2015
38
Long-Term Outcomes of Epithelial Debridement and Diamond Burr Polishing for Corneal Epithelial Irregularity and Recurrent Corneal Erosion. 61
26203746 2015
39
Superior Perilimbal Epitheliopathy in Recurrent Corneal Erosion Syndrome. 61
26203756 2015
40
Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions. 61
25129839 2015
41
Autologous serum eye drops for the treatment of ocular surface disease. 61
25603439 2015
42
Genes in dizygote twins with Bowman layer corneal dystrophy. 61
25785536 2015
43
Optical coherence tomography findings in recurrent corneal erosion syndrome. 61
25532997 2015
44
Microbiological study of therapeutic soft contact lenses used in the treatment of recurrent corneal erosion syndrome. 61
25230080 2015
45
[Diabetic eye disease]. 61
25817504 2015
46
Lattice corneal dystrophy type IIIA with hyaline component from a novel A620P mutation and distinct surgical treatments. 61
25321938 2014
47
[Two cases of phototherapeutic keratectomy treatment of the recurrent corneal erosion caused by alkali burn]. 61
25181507 2014
48
Clinical presentation and causes of recurrent corneal erosion syndrome: review of 100 patients. 61
24699561 2014
49
Granular corneal dystrophy: a novel approach to classification and treatment. 61
24413275 2014
50
Authors' response: A randomised controlled trial of alcohol delamination and phototherapeutic keratectomy for the treatment of recurrent corneal erosion syndrome. 61
24352599 2014

Variations for Recurrent Corneal Erosion

Expression for Recurrent Corneal Erosion

Search GEO for disease gene expression data for Recurrent Corneal Erosion.

Pathways for Recurrent Corneal Erosion

Pathways related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.98 IL6 IL1B FN1 CXCL8
2 11.94 TAC1 IL6 IL1B CXCL8
3 11.84 IL6 IL1B FN1 CXCL8
4 11.83 IL6 IL1B CXCL8
5 11.73 IL6 IL1B FN1 CXCL8
6 11.7 IL6 IL1B CXCL8
7 11.65 IL6 IL1B FN1 CXCL8
8 11.6 IL6 IL1B CXCL8
9
Show member pathways
11.51 IL6 IL1B CXCL8
10 11.5 IL6 IL1B CXCL8
11 11.47 IL6 IL1B FN1 CXCL8
12 11.44 IL6 IL1B CXCL8
13 11.37 IL6 IL1B CXCL8
14 11.34 IL6 IL1B CXCL8
15 11.26 IL6 IL1B FN1 CXCL8
16 10.65 IL6 IL1B
17 10.64 IL6 IL1B FN1 CXCL8 COL8A2 COL17A1
18 10.08 IL6 FN1 CXCL8

GO Terms for Recurrent Corneal Erosion

Cellular components related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 TGFBI TAC1 IL6 IL1B FN1 CXCL8
2 collagen-containing extracellular matrix GO:0062023 9.67 TGFBI FN1 COL8A2 COL17A1
3 endoplasmic reticulum lumen GO:0005788 9.62 IL6 FN1 COL8A2 COL17A1
4 extracellular matrix GO:0031012 9.56 TGFBI FN1 COL8A2 COL17A1
5 extracellular space GO:0005615 9.28 TGFBI TAC1 IL6 IL1B FN1 DNAJC9
6 basement membrane GO:0005604 9.26 TGFBI FN1 COL8A2 COL17A1

Biological processes related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.73 TAC1 IL6 IL1B CXCL8
2 cytokine-mediated signaling pathway GO:0019221 9.56 IL6 IL1B FN1 CXCL8
3 extracellular matrix organization GO:0030198 9.46 TGFBI FN1 COL8A2 COL17A1
4 positive regulation of glial cell proliferation GO:0060252 9.4 IL6 IL1B
5 positive regulation of acute inflammatory response GO:0002675 9.37 TAC1 IL6
6 positive regulation of neuroinflammatory response GO:0150078 9.32 IL6 IL1B
7 angiogenesis GO:0001525 9.26 TGFBI FN1 CXCL8 COL8A2
8 vascular endothelial growth factor production GO:0010573 8.62 IL6 IL1B

Molecular functions related to Recurrent Corneal Erosion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.13 TGFBI IL1B FN1
2 extracellular matrix structural constituent GO:0005201 8.92 TGFBI FN1 COL8A2 COL17A1

Sources for Recurrent Corneal Erosion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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