FRHM
MCID: RCR026
MIFTS: 26

Recurrent Hydatidiform Mole (FRHM)

Categories: Cancer diseases, Fetal diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Recurrent Hydatidiform Mole

MalaCards integrated aliases for Recurrent Hydatidiform Mole:

Name: Recurrent Hydatidiform Mole 53 25
Familial Biparental Hydatidiform Mole 53 25
Familial Recurrent Hydatidiform Mole 53 25
Frhm 53 25
Recurrent Gestational Trophoblastic Tumor 73
Mole, Hydatidiform, Recurrent 40
Recurrent Hydatidiform Moles 37

Classifications:



External Ids:

KEGG 37 H00289
UMLS 73 C0278796

Summaries for Recurrent Hydatidiform Mole

Genetics Home Reference : 25 Recurrent hydatidiform mole occurs when women have at least two abnormal pregnancies described as hydatidiform moles. A hydatidiform mole occurs early in pregnancy when an embryo does not fully develop and the placenta develops abnormally. The placenta is a solid structure in the uterus that normally provides nutrients to a growing fetus. If a hydatidiform mole occurs once, it is known a sporadic hydatidiform mole; if it happens again, the condition is known as recurrent hydatidiform mole.

MalaCards based summary : Recurrent Hydatidiform Mole, also known as familial biparental hydatidiform mole, is related to hydatidiform mole, recurrent, 1 and hydatidiform mole, recurrent, 2. An important gene associated with Recurrent Hydatidiform Mole is NLRP7 (NLR Family Pyrin Domain Containing 7). Affiliated tissues include placenta, uterus and liver.

Related Diseases for Recurrent Hydatidiform Mole

Diseases in the Recurrent Hydatidiform Mole family:

Hydatidiform Mole, Recurrent, 1 Hydatidiform Mole, Recurrent, 2

Diseases related to Recurrent Hydatidiform Mole via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hydatidiform mole, recurrent, 1 11.8
2 hydatidiform mole, recurrent, 2 11.5
3 gestational trophoblastic neoplasm 10.8
4 pre-eclampsia 10.1
5 eclampsia 10.1
6 choriocarcinoma 10.1

Graphical network of the top 20 diseases related to Recurrent Hydatidiform Mole:



Diseases related to Recurrent Hydatidiform Mole

Symptoms & Phenotypes for Recurrent Hydatidiform Mole

Drugs & Therapeutics for Recurrent Hydatidiform Mole

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of the Genetic and Epigenetic Causes of Recurrent Hydatidiform Moles Recruiting NCT01008501

Search NIH Clinical Center for Recurrent Hydatidiform Mole

Genetic Tests for Recurrent Hydatidiform Mole

Anatomical Context for Recurrent Hydatidiform Mole

MalaCards organs/tissues related to Recurrent Hydatidiform Mole:

41
Placenta, Uterus, Liver

Publications for Recurrent Hydatidiform Mole

Articles related to Recurrent Hydatidiform Mole:

(show all 28)
# Title Authors Year
1
Clinical and genetic-epignetic aspects of recurrent hydatidiform mole: A review of literature. ( 29458875 )
2018
2
Two novel mutations in the KHDC3L gene in Asian patients with recurrent hydatidiform mole. ( 27621838 )
2016
3
Live births in women with recurrent hydatidiform mole and two NLRP7 mutations. ( 25982095 )
2015
4
Novel Nonsense Mutation in the NLRP7 Gene Associated with Recurrent Hydatidiform Mole. ( 26606510 )
2015
5
Novel NLRP7 mutations in familial recurrent hydatidiform mole: are NLRP7 mutations a risk for recurrent reproductive wastage? ( 23880596 )
2013
6
Recurrent hydatidiform mole: detection of two novel mutations in the NLRP7 gene in two Egyptian families. ( 22770628 )
2012
7
The spectrum of NLRP7 mutations in French patients with recurrent hydatidiform mole. ( 21439709 )
2011
8
Mutations causing familial biparental hydatidiform mole implicate c6orf221 as a possible regulator of genomic imprinting in the human oocyte. ( 21885028 )
2011
9
Recurrent hydatidiform mole: A case report of six consecutive molar pregnancies complicated by choriocarcinoma, and review of the literature. ( 22175045 )
2011
10
Identification of 13 novel NLRP7 mutations in 20 families with recurrent hydatidiform mole; missense mutations cluster in the leucine-rich region. ( 19246479 )
2009
11
Genetic and epigenetic analysis of recurrent hydatidiform mole. ( 19309689 )
2009
12
Analysis of the chromosomal region 19q13.4 in two Chinese families with recurrent hydatidiform mole. ( 16239310 )
2006
13
Familial recurrent hydatidiform mole: a review. ( 15457849 )
2004
14
Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. ( 12504931 )
2003
15
Extraluminal hyperechogenic echo detected by transvaginal ultrasonography as a prognostic factor in recurrent hydatidiform mole. ( 1283145 )
1992
16
Preimplantation diagnosis and recurrent hydatidiform mole. ( 1970075 )
1990
17
Recurrent hydatidiform mole: a report of a patient with 7 consecutive moles. ( 3233084 )
1988
18
Recurrent hydatidiform mole. Report of a case with five recurrences. ( 696258 )
1978
19
A case of recurrent hydatidiform mole. ( 1235019 )
1975
20
Recurrent hydatidiform mole. A case report of nine consecutive molar pregnancies. ( 4684203 )
1973
21
Recurrent hydatidiform mole: a report of five cases with review of the literature. ( 5357204 )
1969
22
Recurrent hydatidiform mole. Report of a case of four recurrences and a review of the literature. ( 5720477 )
1968
23
Recurrent hydatidiform mole. ( 20328493 )
1966
24
RECURRENT HYDATIDIFORM MOLE; REPORT OF A CASE. ( 14268024 )
1965
25
RECURRENT HYDATIDIFORM MOLE. A CASE REPORT OF 3 CONSECUTIVE MOLES. ( 14194454 )
1964
26
Recurrent hydatidiform mole. ( 13952415 )
1963
27
Recurrent hydatidiform mole. Review of the literature and report of a case. ( 13899813 )
1961
28
Recurrent hydatidiform mole complicated by pre-eclampsia. Case report and review of literature. ( 14420970 )
1959

Variations for Recurrent Hydatidiform Mole

Expression for Recurrent Hydatidiform Mole

Search GEO for disease gene expression data for Recurrent Hydatidiform Mole.

Pathways for Recurrent Hydatidiform Mole

GO Terms for Recurrent Hydatidiform Mole

Sources for Recurrent Hydatidiform Mole

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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