MCID: RCR002
MIFTS: 27

Recurrent Hypersomnia

Categories: Mental diseases, Neuronal diseases

Aliases & Classifications for Recurrent Hypersomnia

MalaCards integrated aliases for Recurrent Hypersomnia:

Name: Recurrent Hypersomnia 12 15
Disorders of Excessive Somnolence 44
Primary Recurrent Hypersomnia 12
Hypersomnia, Recurrent 70
Hypersomnia Recurrent 54

Classifications:



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Disease Ontology 12 DOID:8619
ICD9CM 34 327.13
MeSH 44 D006970
SNOMED-CT 67 426451004
ICD10 32 G47.1 G47.13
UMLS 70 C0751226

Summaries for Recurrent Hypersomnia

Disease Ontology : 12 A sleep disorder that involves recurring bouts of excessive amounts of sleepiness.

MalaCards based summary : Recurrent Hypersomnia, also known as disorders of excessive somnolence, is related to hypersomnia and idiopathic hypersomnia. An important gene associated with Recurrent Hypersomnia is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways is Monoamine Transport. The drugs Modafinil and Central Nervous System Stimulants have been mentioned in the context of this disorder. Affiliated tissues include thalamus.

Related Diseases for Recurrent Hypersomnia

Diseases in the Hypersomnia family:

Recurrent Hypersomnia

Diseases related to Recurrent Hypersomnia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 hypersomnia 31.1 HLA-DQB1 HCRT
2 idiopathic hypersomnia 30.4 HLA-DQB1 HCRT
3 narcolepsy 29.4 SLC6A3 HLA-DQB1 HCRT
4 rem sleep behavior disorder 29.3 SLC6A3 IGLON5 HCRT
5 migraine with or without aura 1 29.1 SLC6A3 HRH3 HCRT
6 sleep disorder 29.1 SLC6A3 IGLON5 HRH3 HCRT
7 kleine-levin hibernation syndrome 29.0 TRANK1 TOR1B SLC6A3 PNMA2 LMOD3 IGLON5
8 narcolepsy 2 10.2 HLA-DQB1 HCRT
9 narcolepsy 1 10.1 HLA-DQB1 HCRT
10 autoimmune disease 10.1
11 sleep apnea 10.0
12 encephalopathy 10.0
13 guillain-barre syndrome 10.0 HLA-DQB1 HCRT
14 apnea, obstructive sleep 9.9 IGLON5 HCRT
15 whipple disease 9.9 PNMA2 IGLON5
16 major affective disorder 8 9.9
17 major affective disorder 9 9.9
18 pervasive developmental disorder 9.9
19 migraine with aura 9.9
20 hepatic coma 9.9
21 brain cancer 9.9
22 hepatic encephalopathy 9.9
23 endogenous depression 9.9
24 status epilepticus 9.9
25 epilepsy 9.9
26 bipolar disorder 9.9
27 mood disorder 9.9
28 migraine with brainstem aura 9.9
29 autonomic dysfunction 9.9
30 brain injury 9.9
31 traumatic brain injury 9.9
32 rare pervasive developmental disorder 9.9
33 dysthymic disorder 9.9 SLC6A3 HCRT
34 withdrawal disorder 9.9 SLC6A3 HCRT
35 acute disseminated encephalomyelitis 9.8 PNMA2 HLA-DQB1 HCRT
36 stiff-person syndrome 9.8 PNMA2 IGLON5
37 postencephalitic parkinson disease 9.8 SLC6A3 IGLON5
38 von economo's disease 9.8 PNMA2 IGLON5 HCRT
39 akinetic mutism 9.7 SLC6A3 PNMA2
40 hematuria, benign familial 9.7 HRH3 HCRT
41 mutism 9.7 SLC6A3 PNMA2
42 eating disorder 9.7 SLC6A3 HCRT
43 lingual-facial-buccal dyskinesia 9.7 SLC6A3 PNMA2
44 supranuclear palsy, progressive, 1 9.6 SLC6A3 IGLON5 HCRT
45 movement disease 9.6 TOR1B SLC6A3 IGLON5
46 choreatic disease 9.5 SLC6A3 PNMA2 IGLON5
47 disease of mental health 8.8 SLC6A3 PNMA2 IGLON5 HRH3 HLA-DQB1 HCRT

Graphical network of the top 20 diseases related to Recurrent Hypersomnia:



Diseases related to Recurrent Hypersomnia

Symptoms & Phenotypes for Recurrent Hypersomnia

Drugs & Therapeutics for Recurrent Hypersomnia

Drugs for Recurrent Hypersomnia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
2 Central Nervous System Stimulants Phase 4
3
Sodium oxybate Approved Phase 2, Phase 3 502-85-2 5360545
4
Sodium citrate Approved, Investigational Phase 2, Phase 3 68-04-2
5
Citric acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 77-92-9 311
6 Anesthetics Phase 2, Phase 3
7 Anesthetics, General Phase 2, Phase 3
8 Anesthetics, Intravenous Phase 2, Phase 3
9 Citrate Phase 2, Phase 3
10
Flumazenil Approved Phase 1, Phase 2 78755-81-4 3373
11
Dopamine Approved Phase 2 62-31-7, 51-61-6 681
12
Amphetamine Approved, Illicit, Investigational Phase 2 300-62-9 5826 3007
13
Dextroamphetamine Approved, Illicit Phase 2 51-64-9 5826
14
Clarithromycin Approved Phase 2 81103-11-9 84029
15 Antidotes Phase 1, Phase 2
16 Protective Agents Phase 1, Phase 2
17 GABA Modulators Phase 1, Phase 2
18 Dopamine Agents Phase 2
19 Sympathomimetics Phase 2
20 adderall Phase 2
21 Dopamine Uptake Inhibitors Phase 2
22 Adrenergic Agents Phase 2
23 Cytochrome P-450 CYP3A Inhibitors Phase 2
24 Cytochrome P-450 Enzyme Inhibitors Phase 2
25 Anti-Bacterial Agents Phase 2
26 Anti-Infective Agents Phase 2
27 Antibiotics, Antitubercular Phase 2
28 Neurotransmitter Agents Phase 2
29 Convulsants Phase 2
30 Pentylenetetrazole Phase 2 54-95-5
31
Caffeine Approved 58-08-2 2519
32
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
33 Hormones
34 Pharmaceutical Solutions

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Tolerability of Armodafinil Treatment (150 mg) in Improving Clinical Condition Late in the Shift and in Improving Functional and Patient-Reported Outcomes in Adult Patients With Excessive Sleepiness Associated With Shift Work Disorder Completed NCT01080807 Phase 4 Armodafinil;Matching Placebo
2 Double-Blind, Placebo-Controlled, Functional Neuroimaging Study of Armodafinil (200 mg/Day) on Prefrontal Cortical Activation in Patients With Residual Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Completed NCT00711516 Phase 4 Armodafinil;Placebo
3 Clinical Trial of Solriamfetol for Excessive Sleepiness Related to Shift Work Disorder Not yet recruiting NCT04788953 Phase 4 Solriamfetol Oral Tablet;Placebo
4 A Double-blind, Placebo-controlled, Randomized Withdrawal, Multicenter Study of the Efficacy and Safety of JZP-258 in the Treatment of Idiopathic Hypersomnia (IH) With an Open-label Safety Extension Completed NCT03533114 Phase 3 JZP-258;Placebo Oral Solution
5 A 12 Week, Randomized, Double Blind, Placebo Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of CEP 10953 (150 mg) as Treatment for Adults With Excessive Sleepiness Associated With Chronic Shift Work Sleep Disorder Completed NCT00080288 Phase 3 Armodafinil 150 mg/day;Placebo
6 A 3-Day, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of the Effect of Armodafinil Treatment (50 and 150 mg/Day) in Healthy Subjects With Excessive Sleepiness Associated With Jet Lag Disorder Completed NCT00758498 Phase 3 armodafinil;armodafinil;placebo
7 A Randomized, Double-blind, Placebo-controlled Trial Comparing the Efficacy and Tolerance of Sodium Oxybate in Patients Affected With Idiopathic Hypersomnia Recruiting NCT03597555 Phase 2, Phase 3 Sodium Oxybate Oral Solution 500 MG/ML;Placebos
8 The Role of Palliative Care Interventions to Reduce Circadian Rhythm Disorders in Persons With Dementia: The Healthy Patterns Study Recruiting NCT03682185 Phase 3
9 A Ten Subject, Double-Blind, Placebo-Controlled Trial of Single Day Dosing of Sublingual Flumazenil in Individuals With Primary Hypersomnia or Excessively Long Total Sleep Time and Excess Endogenous Potentiation of GABA-A Receptors Completed NCT01183312 Phase 1, Phase 2 Flumazenil
10 A Randomized, Double-Blind, Placebo-Controlled, Crossover On-Road Driving Study Assessing the Effect of JZP-110 on Driving Performance in Subjects With Excessive Sleepiness Due to Narcolepsy Completed NCT02806908 Phase 2 JZP-110;Placebo
11 A Randomized, Double-Blind, Placebo-Controlled, Crossover On-Road Driving Study Assessing the Effect of JZP-110 on Driving Performance in Subjects With Excessive Sleepiness Due to Obstructive Sleep Apnea Completed NCT02806895 Phase 2 JZP-110;Placebo
12 A Randomized, Placebo-Controlled, Double-blind, Fixed-Dose, Multiple Cohort, Multiple Crossover, Dose-Finding Study of Oral BTD-001 in Adults With Idiopathic Hypersomnia (IH) or Narcolepsy Type 2 Completed NCT02512588 Phase 2 BTD-001;Placebo
13 Clarithromycin for the Treatment of Hypersomnia Completed NCT01146600 Phase 2 Clarithromycin followed by placebo;Placebo then Clarithromycin
14 A 4-Week, Double-blind, Placebo-controlled, Randomized, Multicenter, Crossover Study of the Safety, Efficacy, and Pharmacokinetics of JZP-110 [(R)-2-amino-3-phenylpropylcarbamate Hydrochloride] in Subjects With Parkinson's Disease and Excessive Sleepiness Completed NCT03037203 Phase 2 JZP-110
15 Informing Treatment Decisions in the Central Disorders of Hypersomnolence: A Pragmatic Clinical Trial of Modafinil Versus Amphetamines Recruiting NCT03772314 Phase 2 Modafinil;Amphetamine-Dextroamphetamine
16 Antibiotic-mediated Improvements in Vigilance: Mechanisms of Action of Clarithromycin in Hypersomnia Syndromes Recruiting NCT04026958 Phase 2 Clarithromycin;Placebo
17 A Randomized, Placebo-Controlled, Double-Blind, Crossover Study of Oral BTD-001 in Adults With Idiopathic Hypersomnia Active, not recruiting NCT03542851 Phase 2 Pentetrazol (PTZ);Placebo oral capsule
18 A Phase 1b Randomized, Double-Blind, Placebo-Controlled, Crossover Study of a Single Intravenous Infusion Dose of TAK-925 in Patients With Idiopathic Hypersomnia Completed NCT04091438 Phase 1 TAK-925;TAK-925 Placebo
19 Improving the Assessment of Hypersomnolence Completed NCT02884505
20 The Effects of Mindfulness on Disrupted Sleep in Bipolar Disorder Completed NCT01764035
21 A Randomized Controlled Trial of Effects From a Mandibular Advancement Device in Patients With Obstructive Sleep Apnea and Snoring Completed NCT00477009
22 A Placebo Control, Double Blind, Cross Over Study of Modafinil in Patients With Narcolepsy Completed NCT00174174 Modafinil
23 Population-bases Study to Asses Prevalence of Sleep Disorders and Their Association With Cardiovascular Risk Factors and Diseases Completed NCT01877616
24 Evaluation of Excessive Diurnal Sleepiness by the Expression and Activity of Salivary Amylase in Children With Hypersomnia. Completed NCT01926405
25 The Role of the Circadian System in Neurological Sleep-wake Disorders: Assessment of Circadian and Homeostatic Sleep-wake Regulation and Vigilance With a Poly-nap Protocol Completed NCT03356938
26 Training Protocol for Various Sleep Disorders in Patients With Neurological Disorders Completed NCT00001664
27 Psychosocial Adjunctive Treatment for Hypersomnia (PATH): A Pilot Trial Completed NCT03904238
28 Sleep-Disordered Breathing and CPAP After Adenotonsillectomy in Children Completed NCT01554527
29 Cardiovascular Variability and Heart Rate Arousal Response in Idiopathic Hypersomnia Completed NCT02913651
30 Method of Assessment of Driving Ability in Patients Suffering From Wakefulness Pathologies, Impact of Modafinil Treatment. Completed NCT00916253 Modafinil;Placebo
31 Importance of Sleep Deprivation in Differential Diagnosis of Primary Hypersomnia in Reference Centers Rare Hypersomnia Completed NCT03459300
32 Sustainable Methods, Algorithms, and Research Tools for Delivering Optimal Care Study (SMART DOCS) Completed NCT02037438
33 The Feasibility of a Tailored Music Intervention to Reduce Symptoms of Sleep Disruption in Older Adults With Dementia Completed NCT04157244
34 Neurophysiologic Correlates of Hypersomnia: a High Density EEG Investigation Completed NCT01719315
35 Assessing the Effect of the MYODM Food Supplement on Quality of Life, Fatigue and Hypersomnia in Patients With Myotonic Dystrophy Type 1 Recruiting NCT04634682
36 Coordination of Rare Diseases at Sanford Recruiting NCT01793168
37 Anesthetic Management of Patients With Chronic Sleep Disorders Recruiting NCT04827329
38 Swiss Primary Hypersomnolence and Narcolepsy Cohort Study Recruiting NCT04330963
39 Prevalence and Characteristics of Sleep Disturbances Among Psychiatric Inpatients Recruiting NCT04201392
40 Constitution of a Clinical, Neurophysiological and Biological Cohort for Chronic Sleep Disorders Responsible of Hypersomnolence Recruiting NCT03998020
41 Hypersomnia in Major Depressive Disorder Recruiting NCT04006834
42 Validating the Use of a Novel Subjectively Reported Sleep Vital Sign for the Identification and Management of Sleep Disorders Active, not recruiting NCT03018912
43 Effects of Telemedicine and Humidification for Continous Positive Airway Pressure (CPAP) in OSAS. Not yet recruiting NCT04300166
44 'A Profile of Physical Performance Variables in an Out-patient Adult Population With Narcolepsy' Suspended NCT04419792
45 Disrupted Sleep in the Elderly: Light Exposure Studies Suspended NCT00427323
46 Effect of a Structured Physical Activity Program on Sleep Quality and Sleepiness in Parkinson's Disease Terminated NCT01544465
47 Transcranial Direct Current Stimulation Therapy for Central Hypersomnia Without Cataplexy Terminated NCT03198156
48 Open-label Clinical Trial to Evaluate the Efficacy of Sodium Oxybate (Xyrem®) in the Treatment of Two Under-recognized Clinical Conditions: Post-traumatic Narcolepsy and Post-traumatic Hypersomnia Withdrawn NCT03626727 Early Phase 1 Sodium Oxybate Oral Solution [Xyrem]

Search NIH Clinical Center for Recurrent Hypersomnia

Cochrane evidence based reviews: disorders of excessive somnolence

Genetic Tests for Recurrent Hypersomnia

Anatomical Context for Recurrent Hypersomnia

MalaCards organs/tissues related to Recurrent Hypersomnia:

40
Thalamus

Publications for Recurrent Hypersomnia

Articles related to Recurrent Hypersomnia:

(show all 49)
# Title Authors PMID Year
1
A patient with anti-aquaporin 4 antibody who presented with recurrent hypersomnia, reduced orexin (hypocretin) level, and symmetrical hypothalamic lesions. 54 61
18226957 2009
2
[Tularaemia in two patients referred on suspicion of cancer mammae and cancer occulta]. 61
33000721 2020
3
Usefulness of brain SPECT imaging in the study of recurrent hypersomnia: Kleine-Levin syndrome. 61
28869046 2019
4
Kleine-Levin syndrome: A neuropsychiatric disorder. 61
29606318 2018
5
Recurrent Hypersomnia and Autonomic Dysregulation in Posttraumatic Stress Disorder. 61
29117891 2017
6
A Case of Recurrent Hypersomnia With Autonomic Dysfunction. 61
28633719 2017
7
Migraine with brainstem aura presenting as recurrent hypersomnia (Kleine-Levin syndrome). 61
27343267 2016
8
Kleine-Levin Syndrome. 61
27137943 2016
9
Recurrent hypersomnia in an 18-year old boy: CSF hypocretin level and MSLT findings. 61
26323648 2016
10
Do the Symptoms of Kleine-Levin Syndrome Correlate With the Hypometabolism of the Thalamus on FDG PET? 61
26562572 2016
11
Menstruation-Related Hypersomnia Treated with Hormonal Contraception: Case Report and Review of Literature. 61
26932284 2016
12
Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention. 61
27308960 2016
13
Recurrent hypersomnia: Report of medication-responsive cases. 61
26483951 2015
14
Narcolepsy with and without cataplexy, idiopathic hypersomnia with and without long sleep time: a cluster analysis. 61
25576137 2015
15
Misdiagnosis of menstruation-related recurrent hypersomnia as epilepsy in a patient with generalized epileptic discharges. 61
25878739 2015
16
Treatment of Kleine-Levin syndrome with acetazolamide. 61
25317098 2014
17
Kleine-Levin syndrome: a case report and review of literature. 61
24630285 2014
18
Kleine-Levin syndrome: a review. 61
24470783 2014
19
[The Kleine-Levin syndrome: new aspects of a rare disease]. 61
23942582 2013
20
Recurrent hypersomnia following traumatic brain injury. 61
23499199 2013
21
Diagnosis and management of central hypersomnias. 61
22973425 2012
22
Recurrent hypersomnia due to occult hepatic encephalopathy. 61
22154356 2012
23
Recurrent hypersomnia: a review of 339 cases. 61
20970360 2011
24
Familial recurrent hypersomnia: two siblings with Kleine-Levin syndrome and menstrual-related hypersomnia. 61
20404354 2010
25
[A case of recurrent hypersomnia with excellent response to lithium carbonate]. 61
21061548 2010
26
Non-convulsive status epilepticus presenting as recurrent hypersomnia. 61
20463123 2010
27
Gabapentin for Kleine-Levin syndrome. 61
19571456 2009
28
Polysomnography in Kleine-Levin syndrome. 61
18316691 2008
29
Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin. 61
18246980 2007
30
Hypersomnias of central origin. 61
16963696 2006
31
Differential diagnosis in hypersomnia. 61
16522270 2006
32
Hypersomnia. 61
16416710 2005
33
Case study: differences in human Per2 gene expression, body temperature, cortisol, and melatonin parameters in remission and hypersomnia in a patient with recurrent hypersomnia. 61
14535361 2003
34
[Recurrent hypersomnia]. 61
14503208 2003
35
Decreased blood flow of the left thalamus during somnolent episodes in a case of recurrent hypersomnia. 61
12047594 2002
36
Recurrent hyper- and hyposomnia: a new diagnostic entity? Polysomnographic findings and a 30-year follow-up. 61
14592248 2002
37
[Disorders of awakening. Second part: secondary disorders]. 61
11438768 2001
38
Kleine Levin syndrome (KLS) in young females. 61
10875563 2000
39
Prolonged polysomnography in a case with recurrent hypersomnia. 61
9628153 1998
40
[Recurrent hypersomnia]. 61
9503836 1998
41
Recurrent hypersomina: a case report with polysomnographic findings. 61
11847365 1997
42
Treatment of recurrent hypersomnia with methylcobalamin (vitamin B12): a case report. 61
8726119 1995
43
Electrophysiological and immunogenetic findings in recurrent monosymptomatic-type hypersomnia: a study of two unrelated Italian cases. 61
8256576 1993
44
Recurrent hypersomnia in two adolescent males with Asperger's syndrome. 61
1644738 1992
45
[Recurrent hypersomnia caused by acute toluene poisoning]. 61
2361041 1990
46
[Recurrent hypersomnia]. 61
3047832 1988
47
Recurrent hypersomnia secondary to sleep apnea. 61
718480 1978
48
Recurrent hypersomnia secondary to sleep apnea. 61
889488 1977
49
[Kleine-Levin syndrome (recurrent hypersomnia of male adolescents]. 61
5559004 1971

Variations for Recurrent Hypersomnia

Expression for Recurrent Hypersomnia

Search GEO for disease gene expression data for Recurrent Hypersomnia.

Pathways for Recurrent Hypersomnia

Pathways related to Recurrent Hypersomnia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.26 SLC6A3 HRH3

GO Terms for Recurrent Hypersomnia

Sources for Recurrent Hypersomnia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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