MCID: RCR002
MIFTS: 29

Recurrent Hypersomnia

Categories: Neuronal diseases, Mental diseases

Aliases & Classifications for Recurrent Hypersomnia

MalaCards integrated aliases for Recurrent Hypersomnia:

Name: Recurrent Hypersomnia 12 15
Disorders of Excessive Somnolence 44
Primary Recurrent Hypersomnia 12
Hypersomnia, Recurrent 73
Hypersomnia Recurrent 55

Classifications:



External Ids:

Disease Ontology 12 DOID:8619
ICD10 33 G47.13 G47.1
ICD9CM 35 327.13
MeSH 44 D006970
SNOMED-CT 68 426451004
UMLS 73 C0751226

Summaries for Recurrent Hypersomnia

Disease Ontology : 12 A sleep disorder that involves recurring bouts of excessive amounts of sleepiness.

MalaCards based summary : Recurrent Hypersomnia, also known as disorders of excessive somnolence, is related to hypersomnia and kleine-levin hibernation syndrome. An important gene associated with Recurrent Hypersomnia is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are CD28 co-stimulation and Immune response Antigen presentation by MHC class II. Affiliated tissues include brain and thalamus, and related phenotype is cardiovascular system.

Related Diseases for Recurrent Hypersomnia

Diseases in the Hypersomnia family:

Recurrent Hypersomnia

Diseases related to Recurrent Hypersomnia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 hypersomnia 30.0 HCRT HLA-DQB1
2 kleine-levin hibernation syndrome 28.6 HCRT HLA-DQB1 HLA-DQB2 HRH3 RPS6KB2
3 sleep apnea 9.8
4 brain injury 9.7
5 traumatic brain injury 9.7
6 hepatic encephalopathy 9.7
7 status epilepticus 9.7
8 epilepsy 9.7
9 migraine with brainstem aura 9.7
10 autonomic dysfunction 9.7
11 encephalopathy 9.7
12 idiopathic hypersomnia 9.7 HCRT HLA-DQB1
13 acute disseminated encephalomyelitis 9.6 HCRT HLA-DQB1
14 guillain-barre syndrome 9.4 HCRT HLA-DQB1
15 migraine with or without aura 1 9.4 HCRT HRH3
16 type 1 diabetes mellitus 6 9.4 HLA-DQB1 HLA-DQB2
17 geographic tongue 9.3 HLA-DQB1 HLA-DQB2
18 celiac disease 1 9.1 HLA-DQB1 HLA-DQB2
19 narcolepsy 8.3 HCRT HLA-DQB1 HLA-DQB2 HRH3

Graphical network of the top 20 diseases related to Recurrent Hypersomnia:



Diseases related to Recurrent Hypersomnia

Symptoms & Phenotypes for Recurrent Hypersomnia

MGI Mouse Phenotypes related to Recurrent Hypersomnia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 8.92 HCRT HLA-DQB1 HRH3 RPS6KB2

Drugs & Therapeutics for Recurrent Hypersomnia

Search Clinical Trials , NIH Clinical Center for Recurrent Hypersomnia

Cochrane evidence based reviews: disorders of excessive somnolence

Genetic Tests for Recurrent Hypersomnia

Anatomical Context for Recurrent Hypersomnia

MalaCards organs/tissues related to Recurrent Hypersomnia:

41
Brain, Thalamus

Publications for Recurrent Hypersomnia

Articles related to Recurrent Hypersomnia:

(show all 20)
# Title Authors Year
1
A Case of Recurrent Hypersomnia With Autonomic Dysfunction. ( 28633719 )
2017
2
Recurrent Hypersomnia and Autonomic Dysregulation in Posttraumatic Stress Disorder. ( 29117891 )
2017
3
Usefulness of brain SPECT imaging in the study of recurrent hypersomnia: Kleine-Levin syndrome. ( 28869046 )
2017
4
Migraine with brainstem aura presenting as recurrent hypersomnia (Kleine-Levin syndrome). ( 27343267 )
2016
5
Recurrent hypersomnia in an 18-year old boy: CSF hypocretin level and MSLT findings. ( 26323648 )
2015
6
Misdiagnosis of menstruation-related recurrent hypersomnia as epilepsy in a patient with generalized epileptic discharges. ( 25878739 )
2015
7
Recurrent hypersomnia: Report of medication-responsive cases. ( 26483951 )
2015
8
Recurrent hypersomnia following traumatic brain injury. ( 23499199 )
2013
9
Recurrent hypersomnia due to occult hepatic encephalopathy. ( 22154356 )
2012
10
Recurrent hypersomnia: a review of 339 cases. ( 20970360 )
2011
11
Non-convulsive status epilepticus presenting as recurrent hypersomnia. ( 20463123 )
2010
12
Familial recurrent hypersomnia: two siblings with Kleine-Levin syndrome and menstrual-related hypersomnia. ( 20404354 )
2010
13
A patient with anti-aquaporin 4 antibody who presented with recurrent hypersomnia, reduced orexin (hypocretin) level, and symmetrical hypothalamic lesions. ( 18226957 )
2009
14
Case study: differences in human Per2 gene expression, body temperature, cortisol, and melatonin parameters in remission and hypersomnia in a patient with recurrent hypersomnia. ( 14535361 )
2003
15
Decreased blood flow of the left thalamus during somnolent episodes in a case of recurrent hypersomnia. ( 12047594 )
2002
16
Prolonged polysomnography in a case with recurrent hypersomnia. ( 9628153 )
1998
17
Treatment of recurrent hypersomnia with methylcobalamin (vitamin B12): a case report. ( 8726119 )
1995
18
Recurrent hypersomnia in two adolescent males with Asperger's syndrome. ( 1644738 )
1992
19
Recurrent hypersomnia secondary to sleep apnea. ( 718480 )
1978
20
Recurrent hypersomnia secondary to sleep apnea. ( 889488 )
1977

Variations for Recurrent Hypersomnia

Expression for Recurrent Hypersomnia

Search GEO for disease gene expression data for Recurrent Hypersomnia.

Pathways for Recurrent Hypersomnia

GO Terms for Recurrent Hypersomnia

Cellular components related to Recurrent Hypersomnia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 trans-Golgi network membrane GO:0032588 9.4 HLA-DQB1 HLA-DQB2
2 endocytic vesicle membrane GO:0030666 9.37 HLA-DQB1 HLA-DQB2
3 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQB1 HLA-DQB2
4 transport vesicle membrane GO:0030658 9.26 HLA-DQB1 HLA-DQB2
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DQB2
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DQB2
7 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DQB2

Biological processes related to Recurrent Hypersomnia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.37 HLA-DQB1 HLA-DQB2
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.32 HLA-DQB1 HLA-DQB2
3 T cell costimulation GO:0031295 9.26 HLA-DQB1 HLA-DQB2
4 interferon-gamma-mediated signaling pathway GO:0060333 9.16 HLA-DQB1 HLA-DQB2
5 antigen processing and presentation GO:0019882 8.96 HLA-DQB1 HLA-DQB2
6 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.62 HLA-DQB1 HLA-DQB2

Molecular functions related to Recurrent Hypersomnia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DQB2

Sources for Recurrent Hypersomnia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....