MCID: RCR004
MIFTS: 46

Recurrent Respiratory Papillomatosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Recurrent Respiratory Papillomatosis

MalaCards integrated aliases for Recurrent Respiratory Papillomatosis:

Name: Recurrent Respiratory Papillomatosis 53 59 73
Juvenile-Onset Recurrent Respiratory Papillomatosis 53
Adult-Onset Recurrent Respiratory Papillomatosis 53
Respiratory Papillomatosis, Recurrent 53
Laryngeal Papilloma, Recurrent 53
Juvenile Laryngeal Papilloma 53
Aorrp 53
Jorrp 53
Rrp 53

Characteristics:

Orphanet epidemiological data:

59
recurrent respiratory papillomatosis
Age of onset: Adolescent,Adult,Childhood;

Classifications:

Orphanet: 59  
Rare respiratory diseases


External Ids:

Orphanet 59 ORPHA60032
UMLS via Orphanet 74 C1168198
MESH via Orphanet 45 C535297
UMLS 73 C1168198

Summaries for Recurrent Respiratory Papillomatosis

NIH Rare Diseases : 53 Recurrent respiratory papillomatosis (RRP) is a rare viral disease where tumors (papillomas) grow in the air passages leading from the nose and mouth into the lungs (respiratory tract). Although the tumors can grow anywhere in the respiratory tract, their presence in the larynx (voice box) causes the most frequent problems, a condition called laryngeal papillomatosis. The tumors may vary in size and grow very quickly. They often grow back even when removed. RRP is caused by two types of human papillomavirus (HPV), called HPV 6 and HPV 11.

MalaCards based summary : Recurrent Respiratory Papillomatosis, also known as juvenile-onset recurrent respiratory papillomatosis, is related to rubella and mumps. An important gene associated with Recurrent Respiratory Papillomatosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. The drugs Cidofovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and t cells.

Related Diseases for Recurrent Respiratory Papillomatosis

Diseases related to Recurrent Respiratory Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 rubella 30.3 HLA-DQB1 HLA-DRB1
2 mumps 30.3 HLA-DRB1 IL2
3 diabetes mellitus 28.5 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
4 laryngeal papillomatosis 11.2
5 limbic encephalitis with lgi1 antibodies 10.6 HLA-DQB1 HLA-DRB1
6 metal allergy 10.6 HLA-DQB1 HLA-DRB1
7 hypersomnia 10.6 HLA-DQB1 HLA-DRB1
8 lichen planopilaris 10.6 HLA-DQB1 HLA-DRB1
9 type ii mixed cryoglobulinemia 10.5 HLA-DQB1 HLA-DRB1
10 beryllium disease 10.5 HLA-DQB1 HLA-DRB1
11 autoimmune pancreatitis 10.5 HLA-DQB1 HLA-DRB1
12 chronic beryllium disease 10.5 HLA-DQB1 HLA-DRB1
13 pityriasis rosea 10.5 HLA-DQB1 HLA-DRB1
14 lichen sclerosus 10.5 HLA-DQB1 HLA-DRB1
15 whipple disease 10.5 HLA-DQB1 HLA-DRB1
16 acute disseminated encephalomyelitis 10.5 HLA-DQB1 HLA-DRB1
17 pediatric multiple sclerosis 10.5 HLA-DQB1 HLA-DRB1
18 osteonecrosis of the jaw 10.5 HLA-DQB1 HLA-DRB1
19 berylliosis 10.5 HLA-DRB1 IL2
20 peanut allergy 10.5 HLA-DQB1 HLA-DRB1
21 panuveitis 10.4 HLA-DQB1 HLA-DRB1
22 microscopic colitis 10.4 HLA-DRB1 IL2
23 severe hemophilia a 10.4 HLA-DQB1 HLA-DRB1
24 pure red-cell aplasia 10.4 HLA-DRB1 IL2
25 ocular cicatricial pemphigoid 10.4 HLA-DQB1 HLA-DRB1
26 limited scleroderma 10.4 HLA-DRB1 IL2
27 rheumatic fever 10.4 HLA-DRB1 IL2
28 discoid lupus erythematosus 10.3 HLA-DRB1 IFNA2
29 paraneoplastic pemphigus 10.3 HLA-DQB1 HLA-DRB1
30 idiopathic inflammatory myopathy 10.3 HLA-DQA1 HLA-DRB1
31 papilloma 10.3
32 achalasia, familial esophageal 10.3 HLA-DQA1 HLA-DQB1
33 eosinophilia-myalgia syndrome 10.3 HLA-DQA1 HLA-DRB1
34 sympathetic ophthalmia 10.2 HLA-DQA1 HLA-DRB1
35 squamous cell carcinoma 10.2
36 congenital toxoplasmosis 10.2 HLA-DQA1 HLA-DQB1
37 exanthem 10.2 EGFR IL2
38 endometritis 10.2 HLA-DQA1 HLA-DQB1
39 laryngitis 10.2
40 bone inflammation disease 10.1 HLA-DRB1 IL2
41 rheumatic heart disease 10.1 HLA-DQA1 HLA-DRB1
42 herpes zoster 10.1 IFNA2 IL2
43 aging 10.1
44 dermatitis herpetiformis 10.1 HLA-DQA1 HLA-DQB1
45 penile cancer 10.1 EGFR IFNA2
46 hypersensitivity reaction disease 10.0 HLA-DRB1 IL2
47 graft-versus-host disease 10.0 HLA-DQB1 HLA-DRB1 IL2
48 helicobacter pylori infection 10.0 EGFR HLA-DRB1
49 hairy cell leukemia 10.0 IFNA2 IL2
50 geographic tongue 10.0 EGFR HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Recurrent Respiratory Papillomatosis:



Diseases related to Recurrent Respiratory Papillomatosis

Symptoms & Phenotypes for Recurrent Respiratory Papillomatosis

Drugs & Therapeutics for Recurrent Respiratory Papillomatosis

Drugs for Recurrent Respiratory Papillomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cidofovir Approved Phase 4,Phase 2 113852-37-2 60613
2 Anti-Infective Agents Phase 4,Phase 2
3 Antiviral Agents Phase 4,Phase 3,Phase 2
4 Vaccines Phase 3,Early Phase 1
5 Antibodies Phase 3,Phase 2
6 Immunoglobulins Phase 3,Phase 2
7
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
8
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
9
Pembrolizumab Approved Phase 2 1374853-91-4
10
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
11 Retinol palmitate Phase 2
12 Angiogenesis Inhibitors Phase 2,Phase 1
13 Angiogenesis Modulating Agents Phase 2,Phase 1
14 Pharmaceutical Solutions Phase 2
15 Analgesics Phase 2
16 Cyclooxygenase 2 Inhibitors Phase 2
17 Cyclooxygenase Inhibitors Phase 2
18 Analgesics, Non-Narcotic Phase 2
19 Peripheral Nervous System Agents Phase 2
20 Anti-Inflammatory Agents Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 2
22 Antirheumatic Agents Phase 2
23 Antibodies, Monoclonal Phase 2
24 retinol Nutraceutical Phase 2
25
Vitamin D Approved, Nutraceutical, Vet_approved Phase 1 1406-16-2
26
Ergocalciferol Approved, Nutraceutical Phase 1 50-14-6 5280793
27 Micronutrients Phase 1
28 Trace Elements Phase 1
29 Ergocalciferols Phase 1
30 Vitamins Phase 1
31 Bone Density Conservation Agents Phase 1
32 Vitamin D2 Nutraceutical Phase 1
33 Calciferol Nutraceutical Phase 1
34
3,3'-diindolylmethane Investigational Not Applicable 1968-05-4
35 Pepsin A Not Applicable
36 Protective Agents Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Use of Cidofovir for Recurrent Respiratory Papillomatosis Completed NCT00205374 Phase 4 Cidofovir;Placebo
2 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
3 4-valent HPV Vaccine to Treat Recurrent Respiratory Papillomatosis in Children Unknown status NCT01995721 Phase 3
4 Effect of Vaccination in Patients With Recurrent Respiratory Papillomatosis Active, not recruiting NCT01375868 Phase 3
5 Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis Withdrawn NCT01058317 Phase 2, Phase 3 Propranolol
6 Bevacizumab Versus Cidofovir for the Treatment of Recurrent Respiratory Papillomatosis Unknown status NCT02555800 Phase 2 Bevacizumab;Cidofovir
7 Study of Celebrex (Celecoxib) in Patients With Recurrent Respiratory Papillomatosis Completed NCT00571701 Phase 2 celebrex (celecoxib);placebo
8 A Trial Study of SGN-00101 in Treating Pediatric Patients With Recurrent Respiratory Papillomatosis Completed NCT00038714 Phase 2 SGN-00101
9 Pembrolizumab for HPV-associated Recurrent Respiratory Papilloma Patients With Laryngeal, Tracheal and/or Pulmonary Involvement Recruiting NCT02632344 Phase 2 Pembrolizumab
10 Avelumab for People With Recurrent Respiratory Papillomatosis Active, not recruiting NCT02859454 Phase 2 Avelumab
11 Bevacizumab for Treatment of Recurrent Respiratory Papillomatosis (RRP) Completed NCT01020747 Phase 1 Avastin® (bevacizumab);Saline
12 Safety Study of EF-022 in Adults With Recurrent Respiratory Papillomatosis (RRP) Not yet recruiting NCT02854761 Phase 1 EF-022 (Modified Vitamin D Binding Protein Macrophage Activator)
13 Multi-Center, Randomized Trial of the Pulsed Dye Laser for JORRP Completed NCT00550914
14 Human Papillomatosis Genotyping of Children in Thailand Completed NCT01304966
15 Human Papillomavirus 6/11 in the Lower Airway of Neonates Completed NCT00549250
16 Value of Narrow Band Imaging (NBI) Endoscopy in the Early Diagnosis of Laryngeal Cancer and Precancerous Lesions Completed NCT02217358 Not Applicable
17 Recurrent Respiratory Papillomatosis and Extraesophageal Reflux Recruiting NCT02592902 Not Applicable
18 Airway Intervention Registry (AIR): Recurrent Respiratory Papillomatosis (RRP) Recruiting NCT03465280
19 New Therapy of Laryngeal Papilloma In Children Terminated NCT00591305 Not Applicable
20 Therapeutic Treatment With Human Papillomavirus Quadrivalent Vaccine for Recurrent Respiratory Papillomatosis Withdrawn NCT00829608 Early Phase 1
21 Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease Withdrawn NCT00733252

Search NIH Clinical Center for Recurrent Respiratory Papillomatosis

Genetic Tests for Recurrent Respiratory Papillomatosis

Anatomical Context for Recurrent Respiratory Papillomatosis

MalaCards organs/tissues related to Recurrent Respiratory Papillomatosis:

41
Lung, Bone, T Cells, Testes, Trachea, Spinal Cord

Publications for Recurrent Respiratory Papillomatosis

Articles related to Recurrent Respiratory Papillomatosis:

(show top 50) (show all 404)
# Title Authors Year
1
Recurrent respiratory papillomatosis. ( 29800325 )
2018
2
Development of Human-Derived Cell Culture Lines for Recurrent Respiratory Papillomatosis. ( 29759030 )
2018
3
A Prospective Study of the Incidence of Juvenile-Onset Recurrent Respiratory Papillomatosis After Implementation of a National HPV Vaccination Program. ( 29136168 )
2018
4
Squamous Cell Papillomatosis in the Setting of Recurrent Respiratory Papillomatosis. ( 29594918 )
2018
5
Clinical and sociodemographic characteristics associated with disease severity in juvenile recurrent respiratory papillomatosis: A study of 104 patients in a tertiary care pediatric hospital. ( 29605367 )
2018
6
Reply to Fernandez-Bussy et al.: Recurrent Respiratory Papillomatosis and Bevacizumab Treatment. ( 28968137 )
2018
7
Current and future management of recurrent respiratory papillomatosis. ( 29492465 )
2018
8
Juvenile-Onset Recurrent Respiratory Papillomatosis: The Benefits of Quadrivalent Human Papillomavirus Vaccination Continue to Accrue. ( 29136167 )
2018
9
A retrospective case control analysis of the efficacy of Gardasil<sup>Ar</sup>vaccination in 28 patients with recurrent respiratory papillomatosis of the larynx. ( 29380936 )
2018
10
Recurrent Respiratory Papillomatosis and Bevacizumab Treatment. ( 28968150 )
2018
11
PD-L1 expression and CD8+ infiltration shows heterogeneity in juvenile recurrent respiratory papillomatosis. ( 28576522 )
2017
12
The PD-1 and PD-L1 pathway in recurrent respiratory papillomatosis. ( 28940446 )
2017
13
Human Papillomavirus (HPV) Genotype Distribution in Patients with Recurrent Respiratory Papillomatosis (RRP) in Iran ( 28749631 )
2017
14
A case of video-assisted thoracoscopic resection of malignant transformation of pulmonary recurrent respiratory papillomatosis. ( 28523179 )
2017
15
Treatment With Quadrivalent Human Papillomavirus Vaccine for Juvenile-Onset Recurrent Respiratory Papillomatosis: Case Report and Review of the Literature. ( 28992265 )
2017
16
Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients. ( 28298239 )
2017
17
Quality and readability assessment of websites related to recurrent respiratory papillomatosis. ( 28233911 )
2017
18
HLA-DRB1 and HLA-DQB1 alleles in Chinese Han patients with Juvenile-Onset recurrent respiratory papillomatosis. ( 29106857 )
2017
19
Recurrent respiratory papillomatosis: A state-of-the-art review. ( 28427542 )
2017
20
Recurrent respiratory papillomatosis in a parturient presenting for cesarean delivery. ( 28347573 )
2017
21
Therapeutic use of the HPV vaccine in Recurrent Respiratory Papillomatosis: A case report. ( 28109479 )
2017
22
Treatment outcomes of recurrent respiratory papillomatosis : Retrospective analysis of juvenile and adult cases. ( 28840259 )
2017
23
Lymphocyte profile and cytokine mRNA expression in peripheral blood mononuclear cells of patients with recurrent respiratory papillomatosis suggest dysregulated cytokine mRNA response and impaired cytotoxic capacity. ( 28805308 )
2017
24
Comparison of cidofovir and the measles, mumps, and rubella vaccine in the treatment of recurrent respiratory papillomatosis. ( 28231366 )
2017
25
Quality of life of young patients with recurrent respiratory papillomatosis. ( 28193306 )
2017
26
Pegylated interferon for treating severe recurrent respiratory papillomatosis in a child: case report. ( 28977096 )
2017
27
Recurrent Respiratory Papillomatosis, more than two entities. ( 29293985 )
2017
28
Recurrent respiratory papillomatosis with lung and chest wall involvement: A rare complication in an adolescent. ( 28233516 )
2017
29
In-office vs. operating room procedures for recurrent respiratory papillomatosis. ( 28489241 )
2017
30
Systemic Bevacizumab for Recurrent Respiratory Papillomatosis: A Single Center Experience of Two Cases. ( 28757601 )
2017
31
Enhanced TH2-like peripheral adaptive immune responses in Juvenile-onset Recurrent Respiratory Papillomatosis (JORRP). ( 28860041 )
2017
32
Systemic bevacizumab for recurrent respiratory papillomatosis: A national survey. ( 28657692 )
2017
33
Laryngeal distribution of recurrent respiratory papillomatosis in a previously untreated cohort. ( 28714564 )
2017
34
Age of diagnosis, incidence and prevalence of recurrent respiratory papillomatosis-A South African perspective. ( 29054106 )
2017
35
Recurrent respiratory papillomatosis (RRP)-time for a reckoning? ( 28894838 )
2017
36
Is recurrent respiratory papillomatosis a manageable or curable disease? ( 26608928 )
2016
37
Validation of the Distress Thermometer and Problem List in Patients with Recurrent Respiratory Papillomatosis. ( 27600632 )
2016
38
Response to letter to Editor: &amp;quot;The clinical course of recurrent respiratory papillomatosis after the use of cidofovir is influenced by multiple factors&amp;quot; by Michel R. M. San Giorgi et al. ( 27654254 )
2016
39
Effectiveness of the human papillomavirus (types 6, 11, 16, and 18) vaccine in the treatment of children with recurrent respiratory papillomatosis. ( 26968061 )
2016
40
Prevalence and management of Recurrent Respiratory Papillomatosis (RRP) in the UK: cross sectional study. ( 27208548 )
2016
41
Quality of life of patients with recurrent respiratory papillomatosis. ( 27861969 )
2016
42
Intersurgical interval increased with use of quadrivalent human papillomavirus vaccine (Gardasil) in a pediatric patient with recurrent respiratory papillomatosis: A case report. ( 27863633 )
2016
43
Juvenile recurrent respiratory papillomatosis: 10-year audit and Australian prevalence estimates. ( 27074766 )
2016
44
Determination of the complete genome and functional analysis of HPV6 isolate VBD19/10 from a patient with aggressive recurrent respiratory papillomatosis. ( 26931553 )
2016
45
Immunological response to quadrivalent HPV vaccine in treatment of recurrent respiratory papillomatosis. ( 27188508 )
2016
46
Office-Based vs Traditional Operating Room Management of Recurrent Respiratory Papillomatosis: Impact of Patient Characteristics and Disease Severity. ( 27658005 )
2016
47
The association between gastroesophageal reflux disease and recurrent respiratory papillomatosis: A systematic review. ( 27113025 )
2016
48
Multidimensional vocal assessment after laser treatment for recurrent respiratory papillomatosis. ( 27515839 )
2016
49
Laryngopharyngeal reflux and herpes simplex virus type 2 are possible risk factors for adult-onset recurrent respiratory papillomatosis (prospective case-control study). ( 27759910 )
2016
50
Intralesional cidofovir injection for recurrent respiratory papillomatosis in Japan. ( 26860235 )
2016

Variations for Recurrent Respiratory Papillomatosis

Expression for Recurrent Respiratory Papillomatosis

Search GEO for disease gene expression data for Recurrent Respiratory Papillomatosis.

Pathways for Recurrent Respiratory Papillomatosis

Pathways related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 CD274 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1 IFNA2
2
Show member pathways
13.43 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
3
Show member pathways
13.2 CD274 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1
4
Show member pathways
13.02 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1 IFNA2 IL2
5
Show member pathways
12.73 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1
6
Show member pathways
12.6 HLA-DQA1 HLA-DQB1 HLA-DRB1 IFNA2 IL2
7
Show member pathways
12.59 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1
8
Show member pathways
12.42 EGFR IFNA2 IL2
9
Show member pathways
12.41 HLA-DQA1 HLA-DQB1 HLA-DRB1 IFNA2 IL2
10
Show member pathways
12.38 HLA-DQA1 HLA-DQB1 HLA-DRB1
11
Show member pathways
12.34 HLA-DQA1 HLA-DQB1 HLA-DRB1 IFNA2
12
Show member pathways
12.25 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
13 12.2 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
14
Show member pathways
12.16 HLA-DQA1 HLA-DQB1 HLA-DRB1
15
Show member pathways
12.16 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
16 12.11 HLA-DQA1 HLA-DQB1 HLA-DRB1
17
Show member pathways
12.06 HLA-DQA1 HLA-DQB1 HLA-DRB1
18 11.97 HLA-DQA1 HLA-DQB1 HLA-DRB1
19 11.96 HLA-DQA1 HLA-DQB1 HLA-DRB1 IFNA2
20
Show member pathways
11.91 CD274 HLA-DQA1 HLA-DQB1 HLA-DRB1
21 11.77 HLA-DQA1 HLA-DQB1 HLA-DRB1
22 11.73 EGFR IFNA2 IL2
23 11.73 HLA-DQA1 HLA-DQB1 HLA-DRB1
24 11.69 HLA-DQA1 HLA-DQB1 HLA-DRB1
25 11.62 CD274 HLA-DQA1 HLA-DQB1 HLA-DRB1
26 11.56 HLA-DQA1 HLA-DQB1 HLA-DRB1
27 11.54 IFNA2 IL2
28 11.54 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1
29 11.49 EGFR IL2
30
Show member pathways
11.49 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
31 11.43 HLA-DQA1 HLA-DQB1 HLA-DRB1
32 11.37 EGFR IL2
33 11.34 EGFR IL2
34 11.12 HLA-DRB1 IL2
35 11.08 HLA-DRB1 IL2
36
Show member pathways
10.96 CD274 HLA-DQA1 HLA-DQB1 HLA-DRB1

GO Terms for Recurrent Respiratory Papillomatosis

Cellular components related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.76 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1
2 lysosomal membrane GO:0005765 9.65 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 trans-Golgi network membrane GO:0032588 9.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 endocytic vesicle membrane GO:0030666 9.58 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 endosome membrane GO:0010008 9.56 EGFR HLA-DQA1 HLA-DQB1 HLA-DRB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.54 HLA-DQA1 HLA-DQB1 HLA-DRB1
7 transport vesicle membrane GO:0030658 9.5 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 MHC class II protein complex GO:0042613 8.8 HLA-DQA1 HLA-DQB1 HLA-DRB1

Biological processes related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.69 CD274 EGFR IFNA2
2 T cell receptor signaling pathway GO:0050852 9.63 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.55 IFNA2 IL2
5 immune response GO:0006955 9.55 CD274 HLA-DQA1 HLA-DQB1 HLA-DRB1 IL2
6 positive regulation of T cell proliferation GO:0042102 9.54 CD274 IL2
7 interferon-gamma-mediated signaling pathway GO:0060333 9.54 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 negative regulation of T cell proliferation GO:0042130 9.52 CD274 HLA-DRB1
9 positive regulation of phosphorylation GO:0042327 9.49 EGFR IFNA2
10 negative regulation of interferon-gamma production GO:0032689 9.48 CD274 HLA-DRB1
11 antigen processing and presentation GO:0019882 9.43 HLA-DQA1 HLA-DQB1 HLA-DRB1
12 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.4 HLA-DQB1 HLA-DRB1
13 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.32 HLA-DQB1 HLA-DRB1
14 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
15 T cell costimulation GO:0031295 8.92 CD274 HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.8 HLA-DQA1 HLA-DQB1 HLA-DRB1

Sources for Recurrent Respiratory Papillomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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