RRP
MCID: RCR004
MIFTS: 48

Recurrent Respiratory Papillomatosis (RRP)

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Recurrent Respiratory Papillomatosis

MalaCards integrated aliases for Recurrent Respiratory Papillomatosis:

Name: Recurrent Respiratory Papillomatosis 52 58 71
Juvenile-Onset Recurrent Respiratory Papillomatosis 52
Adult-Onset Recurrent Respiratory Papillomatosis 52
Respiratory Papillomatosis, Recurrent 52
Laryngeal Papilloma, Recurrent 52
Juvenile Laryngeal Papilloma 52
Aorrp 52
Jorrp 52
Rrp 52

Characteristics:

Orphanet epidemiological data:

58
recurrent respiratory papillomatosis
Age of onset: Adolescent,Adult,Childhood;

Classifications:

Orphanet: 58  
Rare respiratory diseases


Summaries for Recurrent Respiratory Papillomatosis

NIH Rare Diseases : 52 Recurrent respiratory papillomatosis (RRP) is a rare viral disease where tumors (papillomas) grow in the air passages leading from the nose and mouth into the lungs (respiratory tract). Although the tumors can grow anywhere in the respiratory tract, their presence in the larynx (voice box) causes the most frequent problems, a condition called laryngeal papillomatosis . The tumors may vary in size and grow very quickly. They often grow back even when removed. RRP is caused by two types of human papillomavirus (HPV) , called HPV 6 and HPV 11.

MalaCards based summary : Recurrent Respiratory Papillomatosis, also known as juvenile-onset recurrent respiratory papillomatosis, is related to mumps and cytomegalovirus retinitis. An important gene associated with Recurrent Respiratory Papillomatosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. The drugs Cidofovir and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and tonsil, and related phenotypes are hoarse voice and dysphonia

Related Diseases for Recurrent Respiratory Papillomatosis

Diseases related to Recurrent Respiratory Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 mumps 30.4 IL2 HLA-DRB1 HLA-DQB1
2 cytomegalovirus retinitis 30.3 HLA-DRB1 HLA-DQB1
3 rubella 30.1 IL2 HLA-DRB1 HLA-DQB1
4 oropharynx cancer 29.4 ERBB2 EGFR CD274
5 exanthem 28.9 IL2 ERBB2 EGFR CD274
6 cervical cancer 28.6 IL2 HLA-DQB1 ERBB2 EGFR CD274
7 laryngeal papillomatosis 11.9
8 papilloma 11.3
9 squamous cell papilloma 11.0
10 impotence 10.5
11 anogenital venereal wart 10.4
12 squamous cell carcinoma 10.4
13 limbic encephalitis with lgi1 antibodies 10.3 HLA-DRB1 HLA-DQB1
14 autoimmune polyglandular syndrome type 3 10.3 HLA-DRB1 HLA-DQB1
15 primary adrenal insufficiency 10.3 HLA-DRB1 HLA-DQB1
16 hypersomnia 10.3 HLA-DRB1 HLA-DQB1
17 narcolepsy 2 10.3 HLA-DRB1 HLA-DQB1
18 type ii mixed cryoglobulinemia 10.3 HLA-DRB1 HLA-DQB1
19 moyamoya angiopathy 10.3 HLA-DRB1 HLA-DQB1
20 beryllium disease 10.3 HLA-DRB1 HLA-DQB1
21 tracheal stenosis 10.3
22 in situ carcinoma 10.3
23 apple allergy 10.3 HLA-DRB1 HLA-DQB1
24 chronic beryllium disease 10.3 HLA-DRB1 HLA-DQB1
25 autoimmune hepatitis type 1 10.3 HLA-DRB1 HLA-DQB1
26 focal epithelial hyperplasia 10.3 HLA-DRB1 HLA-DQB1
27 metal allergy 10.3 HLA-DRB1 HLA-DQB1
28 pediatric multiple sclerosis 10.3 HLA-DRB1 HLA-DQB1
29 osteonecrosis of the jaw 10.3 HLA-DRB1 HLA-DQB1
30 narcolepsy 1 10.3 HLA-DRB1 HLA-DQB1
31 idiopathic bronchiectasis 10.3 HLA-DRB1 HLA-DQB1
32 pityriasis rosea 10.3 HLA-DRB1 HLA-DQB1
33 oligoarticular juvenile idiopathic arthritis 10.3 HLA-DRB1 HLA-DQB1
34 whipple disease 10.3 HLA-DRB1 HLA-DQB1
35 ocular cicatricial pemphigoid 10.3 HLA-DRB1 HLA-DQB1
36 cicatricial pemphigoid 10.2 HLA-DRB1 HLA-DQB1
37 paraneoplastic pemphigus 10.2 HLA-DRB1 HLA-DQB1
38 berylliosis 10.2 IL2 HLA-DRB1
39 alveolar echinococcosis 10.2 HLA-DRB1 HLA-DQB1
40 cystic echinococcosis 10.2 HLA-DRB1 HLA-DQB1
41 pars planitis 10.2 IL2 HLA-DRB1
42 acute disseminated encephalomyelitis 10.2 HLA-DRB1 HLA-DQB1
43 acute chest syndrome 10.2 HLA-DRB1 HLA-DQB1
44 panuveitis 10.2 HLA-DRB1 HLA-DQB1
45 cervical dystonia 10.2 HLA-DRB1 HLA-DQB1
46 neutropenia 10.2
47 laryngeal disease 10.2
48 lung disease 10.2
49 cytokine deficiency 10.2
50 intermediate uveitis 10.2 IL2 HLA-DRB1

Graphical network of the top 20 diseases related to Recurrent Respiratory Papillomatosis:



Diseases related to Recurrent Respiratory Papillomatosis

Symptoms & Phenotypes for Recurrent Respiratory Papillomatosis

Human phenotypes related to Recurrent Respiratory Papillomatosis:

58 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hoarse voice 58 31 hallmark (90%) Very frequent (99-80%) HP:0001609
2 dysphonia 58 31 frequent (33%) Frequent (79-30%) HP:0001618
3 respiratory distress 58 31 frequent (33%) Frequent (79-30%) HP:0002098
4 failure to thrive 58 31 occasional (7.5%) Occasional (29-5%) HP:0001508
5 dysphagia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002015
6 respiratory insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0002093
7 recurrent upper respiratory tract infections 58 31 occasional (7.5%) Occasional (29-5%) HP:0002788
8 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
9 recurrent pneumonia 58 31 occasional (7.5%) Occasional (29-5%) HP:0006532
10 upper airway obstruction 58 31 occasional (7.5%) Occasional (29-5%) HP:0002781
11 tachypnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002789
12 stridor 58 31 occasional (7.5%) Occasional (29-5%) HP:0010307
13 wheezing 58 31 occasional (7.5%) Occasional (29-5%) HP:0030828
14 nonproductive cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0031246
15 fever 58 31 very rare (1%) Very rare (<4-1%) HP:0001945
16 atelectasis 58 31 very rare (1%) Very rare (<4-1%) HP:0100750
17 tracheomalacia 58 31 very rare (1%) Very rare (<4-1%) HP:0002779
18 syncope 58 31 very rare (1%) Very rare (<4-1%) HP:0001279
19 squamous cell carcinoma 58 31 very rare (1%) Very rare (<4-1%) HP:0002860
20 choking episodes 58 31 very rare (1%) Very rare (<4-1%) HP:0030842
21 dyspnea 58 Occasional (29-5%)
22 abnormal lung morphology 58 Very rare (<4-1%)
23 abnormal trachea morphology 58 Frequent (79-30%)

GenomeRNAi Phenotypes related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.8 EGFR ERBB2
2 Decreased viability with paclitaxel GR00179-A-3 8.8 EGFR

Drugs & Therapeutics for Recurrent Respiratory Papillomatosis

Drugs for Recurrent Respiratory Papillomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cidofovir Approved Phase 4 113852-37-2 60613
2 Anti-Infective Agents Phase 4
3 Antiviral Agents Phase 4
4 Vaccines Phase 3
5 Immunologic Factors Phase 3
6
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
7
Pembrolizumab Approved Phase 2 1374853-91-4
8
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
9 retinol Phase 2
10 Retinol palmitate Phase 2
11 Pharmaceutical Solutions Phase 2
12 Anti-Inflammatory Agents Phase 2
13 Anti-Inflammatory Agents, Non-Steroidal Phase 2
14 Analgesics, Non-Narcotic Phase 2
15 Cyclooxygenase Inhibitors Phase 2
16 Antirheumatic Agents Phase 2
17 Cyclooxygenase 2 Inhibitors Phase 2
18 Analgesics Phase 2
19 Antineoplastic Agents, Immunological Phase 2
20 Antibodies, Monoclonal Phase 2
21 Immunoglobulins Phase 2
22 Antibodies Phase 2
23
Bevacizumab Approved, Investigational Phase 1 216974-75-3
24
Ergocalciferol Approved, Nutraceutical Phase 1 50-14-6 5280793
25
Vitamin D Approved, Nutraceutical, Vet_approved Phase 1 1406-16-2
26
Calcium Approved, Nutraceutical Phase 1 7440-70-2 271
27 Vitamins Phase 1
28 Micronutrients Phase 1
29 Trace Elements Phase 1
30 Nutrients Phase 1
31 Vitamin D2 Phase 1
32 Ergocalciferols Phase 1
33 Calcium, Dietary Phase 1
34 Calciferol Phase 1
35 Hormones Phase 1
36 Angiogenesis Inhibitors Phase 1
37
3,3'-diindolylmethane Investigational 1968-05-4
38 Pepsin A
39 Protective Agents

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Use of Cidofovir Injection in the Treatment of Recurrent Respiratory Papillomatosis." Completed NCT00205374 Phase 4 Cidofovir;Placebo
2 Assessment of the Safety, Side Effects and Efficacy of Interventional Cryotherapy for the Eradication of Benign Airway Disease("ICE THE BAD") Terminated NCT00747461 Phase 4
3 Phase III, Single-center Clinical Trial to Evaluate the 4-valent HPV Vaccine for the Treatment and Prevention of Recurrent Respiratory Papillomatosis in Children Unknown status NCT01995721 Phase 3
4 Phase IIIb Study of Recombinant Tetravalent HPV Vaccine in Patients With Recurrent Respiratory Papillomatosis Completed NCT01375868 Phase 3
5 Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis Withdrawn NCT01058317 Phase 2, Phase 3 Propranolol
6 Bevacizumab Versus Cidofovir for the Treatment of Recurrent Respiratory Papillomatosis: a Randomized, Double-blind, Placebo-controlled Clinical Trial Unknown status NCT02555800 Phase 2 Bevacizumab;Cidofovir
7 A Phase II Trial of SGN-00101 In The Treatment of Pediatric Recurrent Respiratory Papillomatosis Completed NCT00038714 Phase 2 SGN-00101
8 A Multicentered Randomized Study of Celebrex (Celecoxib) in Patients With Recurrent Respiratory Papillomatosis Completed NCT00571701 Phase 2 celebrex (celecoxib);placebo
9 Pembrolizumab for HPV-associated Recurrent Respiratory Papilloma Patients With Laryngeal, Tracheal and/or Pulmonary Involvement Active, not recruiting NCT02632344 Phase 2 Pembrolizumab
10 A Phase II Study of Avelumab in Subjects With Recurrent Respiratory Papillomatosis Active, not recruiting NCT02859454 Phase 2 Avelumab
11 A Phase II Study of M7824 in Subjects With Recurrent Respiratory Papillomatosis Active, not recruiting NCT03707587 Phase 2 M7824
12 Phase I Safety and Tolerability Study of EF-022 in Adult Subjects With Recurrent Respiratory Papillomatosis Unknown status NCT02854761 Phase 1 EF-022 (Modified Vitamin D Binding Protein Macrophage Activator)
13 A Pilot Study to Evaluate the Effects of Antiangiogenic Factor as an Adjunct Treatment After Photoangiolysis in Patients With Bilateral Recurrent Respiratory Papillomatosis of the Vocal Fold Completed NCT01020747 Phase 1 Avastin® (bevacizumab);Saline
14 A Multi-Center, Randomized, Controlled Trial of the Pulsed Dye Laser for Juvenile Onset Recurrent Respiratory Papillomatosis Completed NCT00550914
15 Human Papillomavirus 6/11 in the Lower Airway of Neonates Completed NCT00549250
16 Recurrent Respiratory Papillomatosis and Extraesophageal Reflux Completed NCT02592902
17 Human Papillomatosis Genotyping and Severity in Patients With Recurrent Respiratory Papillomatosis of Children in Thailand Completed NCT01304966
18 Value of Narrow Band Imaging (NBI) Endoscopy in the Early Diagnosis of Laryngeal Cancer and Precancerous Lesions Completed NCT02217358
19 Airway Intervention Registry (AIR) Extension: Recurrent Respiratory Papillomatosis Recruiting NCT03465280
20 The Natural History of Severe Viral Infections and Characterization of Immune Defects Recruiting NCT01011712
21 Voice Preserving Therapy of Laryngeal Papilloma In Children Terminated NCT00591305
22 Investigator Initiated Study of Effects of Progression of Recurrent Respiratory Papillomatosis in Patients After They Are Given Human Papillomavirus Quadrivalent Vaccine Withdrawn NCT00829608 Early Phase 1
23 Optical Coherence Tomography of Human Airways Withdrawn NCT00733252

Search NIH Clinical Center for Recurrent Respiratory Papillomatosis

Genetic Tests for Recurrent Respiratory Papillomatosis

Anatomical Context for Recurrent Respiratory Papillomatosis

MalaCards organs/tissues related to Recurrent Respiratory Papillomatosis:

40
Lung, Breast, Tonsil, Trachea, Kidney, Thymus, T Cells

Publications for Recurrent Respiratory Papillomatosis

Articles related to Recurrent Respiratory Papillomatosis:

(show top 50) (show all 768)
# Title Authors PMID Year
1
Laryngeal sequelae secondary to surgical treatment for recurrent respiratory papillomatosis in children. 61
31846823 2020
2
Multi-Year Effect of Human Papillomavirus Vaccination on Recurrent Respiratory Papillomatosis. 61
30963598 2020
3
Immunological tolerance of low-risk HPV in recurrent respiratory papillomatosis. 61
31628850 2020
4
Laryngeal Web in the Pediatric Population: Evaluation and Management. 61
31842676 2020
5
Bevacizumab as adjuvant therapy for recurrent respiratory papillomatosis in an infant. 61
31707187 2020
6
The human papillomavirus vaccine as a treatment for human papillomavirus-related dysplastic and neoplastic conditions: A literature review. 61
31085272 2020
7
Immune Therapy Targeting E6/E7 Oncogenes of Human Paillomavirus Type 6 (HPV-6) Reduces or Eliminates the Need for Surgical Intervention in the Treatment of HPV-6 Associated Recurrent Respiratory Papillomatosis. 61
32013270 2020
8
Use of intralesional cidofovir in the recurrent respiratory papillomatosis: a review of the literature. 61
32017003 2020
9
Evaluation of Safety of Intralesional Cidofovir for Adjuvant Treatment of Recurrent Respiratory Papillomatosis. 61
31895450 2020
10
International Pediatric Otolaryngology Group (IPOG): Juvenile-onset recurrent respiratory papillomatosis consensus recommendations. 61
31698245 2020
11
Systemic bevacizumab for end-stage juvenile recurrent respiratory papillomas: A case report. 61
31610441 2020
12
Abnormal Activation of Myeloid Dendritic Cells in JORRP Patients and Associated with Disease Activity. 61
31726188 2020
13
Efficacy of microsurgery in combined with topical-PDT in treating recurrent respiratory papillomatosis: compare JORRP with AORRP. 61
31556770 2019
14
High-throughput screening identifies candidate drugs for the treatment of recurrent respiratory papillomatosis. 61
31446060 2019
15
Role of epstein-barr virus in the severity of recurrent respiratory papillomatosis. 61
31860132 2019
16
The role of human papilloma virus test in men: First exhaustive review of literature. 61
31874781 2019
17
Mitochondrial somatic mutations and the lack of viral genomic variation in recurrent respiratory papillomatosis. 61
31719597 2019
18
Vocal cord surgery and pharmacological treatment of a patient with HPV and recurrent respiratory papillomatosis. 61
31732543 2019
19
Relationship between inflammation and the severity of Recurrent Respiratory Papillomatosis. 61
31787356 2019
20
[The effect and mechanism of 2-methoxyestradiol on human laryngeal papilloma cell line]. 61
31623040 2019
21
[Perspectives on recurrent respiratory papillomatosis and human papillomavirus]. 61
31610833 2019
22
Sicca Syndrome Associated with Immune Checkpoint Inhibitor Therapy. 61
30996010 2019
23
Diverse Endoscopic Techniques for Diagnosing Recurrent Respiratory Papillomatosis. 61
30897951 2019
24
Laryngeal distribution of adult-onset recurrent respiratory papillomatosis: A longitudinal study. 61
31059600 2019
25
CO2 laser "Ablation Suction" technique for treatment of laryngeal recurrent respiratory papillomatosis. 61
30615261 2019
26
Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis. 61
31484767 2019
27
Voice improvement in patients with recurrent respiratory papillomatosis after combined treatment with cidofovir and CO2 laser surgery. 61
30762194 2019
28
Prevalence and clinical implications of low-risk human papillomavirus among patients with recurrent respiratory papillomatosis in Rio de Janeiro, Brazil. 61
30581074 2019
29
Economic burden of HPV9-related diseases: a real-world cost analysis from Italy. 61
30900047 2019
30
[Laryngeal Recurrent Respiratory Papillomatosis: Current Aspects on Diagnosis and Therapy]. 61
31387134 2019
31
Update on Recurrent Respiratory Papillomatosis. 61
31078306 2019
32
Hemoptysis and Bronchiolitis Obliterans in Children with Recurrent Respiratory Papillomatosis: Adverse Reactions to Nebulized Cidofovir. 61
30611599 2019
33
Novel synchronous nasal involvement of inverted papilloma and recurrent respiratory papillomatosis with confirmed human papillomavirus isolated from nasal septum and middle turbinate: a case report. 61
31303177 2019
34
The Prevalence, Anatomic Distribution and Significance of HPV Genotypes in Head and Neck Squamous Papillomas as Detected by Real-Time PCR and Sanger Sequencing. 61
31352627 2019
35
Cost of treating recurrent respiratory papillomavirus in commercially insured and medicaid patients. 61
31194270 2019
36
Paediatric virology and human papillomaviruses: An update. 61
31186676 2019
37
Decoding phonation with artificial intelligence (DeP AI): Proof of concept. 61
31236467 2019
38
Clinical Activity of Nivolumab for Human Papilloma Virus-Related Juvenile-Onset Recurrent Respiratory Papillomatosis. 61
30842242 2019
39
Oral immunization with bacteriophage MS2-L2 VLPs protects against oral and genital infection with multiple HPV types associated with head & neck cancers and cervical cancer. 61
30926288 2019
40
Lack of Association between Human Papillomavirus Types 6 and 11 Genetic Variants and Cervical Abnormalities: The Ludwig-McGill Cohort Study. 61
30867221 2019
41
Squamous Cell Papillomatosis in the Setting of Recurrent Respiratory Papillomatosis. 61
29594918 2019
42
Transformation of Recurrent Respiratory Papillomatosis: Squamous Cell Carcinoma in a Pregnant Teen. 61
30508534 2019
43
Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis. 61
31053174 2019
44
Safety and Immunogenicity of a Nonadjuvant Human Papillomavirus Type 6 Virus-like Particle Vaccine in Recurrent Respiratory Papillomatosis. 61
30224308 2019
45
Clinical relevance of human papillomavirus outside of oropharynx. 61
30724765 2019
46
Implementation of Routine HPV Vaccination in the Management of Recurrent Respiratory Papillomatosis. 61
30595025 2019
47
Prophylactic human papilloma virus vaccination in head and neck: indications and future perspectives. 61
30694913 2019
48
Safe use of systemic bevacizumab for respiratory recurrent papillomatosis in two children. 61
30588638 2019
49
Experimental research on the therapeutic effect of MMR vaccine to juvenile-onset recurrent respiratory papillomatosis. 61
30806807 2019
50
MVA E2 therapeutic vaccine for marked reduction in likelihood of recurrence of respiratory papillomatosis. 61
30605254 2019

Variations for Recurrent Respiratory Papillomatosis

Expression for Recurrent Respiratory Papillomatosis

Search GEO for disease gene expression data for Recurrent Respiratory Papillomatosis.

Pathways for Recurrent Respiratory Papillomatosis

Pathways related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 IL2 HLA-DRB1 HLA-DQB1 ERBB2 EGFR CD274
2
Show member pathways
13.34 IL2 HLA-DRB1 HLA-DQB1 ERBB2 EGFR
3
Show member pathways
13.03 HLA-DRB1 HLA-DQB1 ERBB2 EGFR CD274
4
Show member pathways
12.83 IL2 HLA-DRB1 HLA-DQB1 ERBB2 EGFR
5
Show member pathways
12.39 HLA-DRB1 HLA-DQB1 ERBB2 EGFR
6
Show member pathways
12.35 IL2 EGFR CD274
7
Show member pathways
12.34 IL2 HLA-DRB1 HLA-DQB1 ERBB2 EGFR
8
Show member pathways
12.33 IL2 HLA-DRB1 HLA-DQB1
9
Show member pathways
12.32 IL2 ERBB2 EGFR
10
Show member pathways
12.16 IL2 ERBB2 EGFR
11
Show member pathways
12.08 IL2 HLA-DRB1 HLA-DQB1
12 11.99 IL2 HLA-DRB1 HLA-DQB1
13
Show member pathways
11.85 HLA-DRB1 HLA-DQB1 CD274
14 11.71 HLA-DRB1 HLA-DQB1 CD274
15 11.56 HLA-DRB1 HLA-DQB1 EGFR
16
Show member pathways
11.53 HLA-DRB1 HLA-DQB1
17 11.45 IL2 ERBB2 EGFR
18
Show member pathways
11.43 IL2 ERBB2 EGFR
19 11.33 IL2 EGFR
20 11.28 IL2 EGFR
21 11.24 ERBB2 EGFR
22 11.04 ERBB2 EGFR
23 11.01 ERBB2 EGFR
24 10.97 IL2 HLA-DRB1
25 10.94 IL2 HLA-DRB1
26
Show member pathways
10.84 HLA-DRB1 HLA-DQB1 CD274

GO Terms for Recurrent Respiratory Papillomatosis

Cellular components related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.46 HLA-DRB1 ERBB2 EGFR CD274
2 transport vesicle membrane GO:0030658 9.4 HLA-DRB1 HLA-DQB1
3 basal plasma membrane GO:0009925 9.37 ERBB2 EGFR
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.32 HLA-DRB1 HLA-DQB1
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-DRB1 HLA-DQB1
6 MHC class II protein complex GO:0042613 8.96 HLA-DRB1 HLA-DQB1
7 endosome membrane GO:0010008 8.92 HLA-DRB1 HLA-DQB1 ERBB2 EGFR

Biological processes related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.75 IL2 HLA-DRB1 CD274
2 immune system process GO:0002376 9.73 IL2 HLA-DRB1 HLA-DQB1 CD274
3 MAPK cascade GO:0000165 9.71 IL2 ERBB2 EGFR
4 cell surface receptor signaling pathway GO:0007166 9.65 ERBB2 EGFR CD274
5 immune response GO:0006955 9.62 IL2 HLA-DRB1 HLA-DQB1 CD274
6 positive regulation of protein phosphorylation GO:0001934 9.58 IL2 ERBB2 EGFR
7 cellular response to epidermal growth factor stimulus GO:0071364 9.57 ERBB2 EGFR
8 negative regulation of T cell proliferation GO:0042130 9.56 HLA-DRB1 CD274
9 antigen processing and presentation GO:0019882 9.55 HLA-DRB1 HLA-DQB1
10 regulation of cell motility GO:2000145 9.52 ERBB2 EGFR
11 ERBB2 signaling pathway GO:0038128 9.51 ERBB2 EGFR
12 negative regulation of interferon-gamma production GO:0032689 9.49 HLA-DRB1 CD274
13 regulation of ERK1 and ERK2 cascade GO:0070372 9.46 ERBB2 EGFR
14 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.37 HLA-DRB1 HLA-DQB1
15 negative regulation of ERBB signaling pathway GO:1901185 9.26 ERBB2 EGFR
16 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.16 HLA-DRB1 HLA-DQB1
17 positive regulation of cell growth GO:0030307 9.13 IL2 ERBB2 EGFR
18 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DRB1 HLA-DQB1

Molecular functions related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 ERBB2 EGFR
2 peptide antigen binding GO:0042605 8.96 HLA-DRB1 HLA-DQB1
3 MHC class II receptor activity GO:0032395 8.62 HLA-DRB1 HLA-DQB1

Sources for Recurrent Respiratory Papillomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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