RRP
MCID: RCR004
MIFTS: 50

Recurrent Respiratory Papillomatosis (RRP)

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Recurrent Respiratory Papillomatosis

MalaCards integrated aliases for Recurrent Respiratory Papillomatosis:

Name: Recurrent Respiratory Papillomatosis 53 59 73
Juvenile-Onset Recurrent Respiratory Papillomatosis 53
Adult-Onset Recurrent Respiratory Papillomatosis 53
Respiratory Papillomatosis, Recurrent 53
Laryngeal Papilloma, Recurrent 53
Juvenile Laryngeal Papilloma 53
Aorrp 53
Jorrp 53
Rrp 53

Characteristics:

Orphanet epidemiological data:

59
recurrent respiratory papillomatosis
Age of onset: Adolescent,Adult,Childhood;

Classifications:

Orphanet: 59  
Rare respiratory diseases


External Ids:

Orphanet 59 ORPHA60032
UMLS via Orphanet 74 C1168198
MESH via Orphanet 45 C535297
UMLS 73 C1168198

Summaries for Recurrent Respiratory Papillomatosis

NIH Rare Diseases : 53 Recurrent respiratory papillomatosis (RRP) is a rare viral disease where tumors (papillomas) grow in the air passages leading from the nose and mouth into the lungs (respiratory tract). Although the tumors can grow anywhere in the respiratory tract, their presence in the larynx (voice box) causes the most frequent problems, a condition called laryngeal papillomatosis. The tumors may vary in size and grow very quickly. They often grow back even when removed. RRP is caused by two types of human papillomavirus (HPV), called HPV 6 and HPV 11.

MalaCards based summary : Recurrent Respiratory Papillomatosis, also known as juvenile-onset recurrent respiratory papillomatosis, is related to mumps and rubella. An important gene associated with Recurrent Respiratory Papillomatosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cidofovir and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and t cells, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Recurrent Respiratory Papillomatosis

Diseases related to Recurrent Respiratory Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 mumps 30.2 HLA-DRB1 IL2
2 rubella 30.1 HLA-DQB1 HLA-DRB1
3 laryngeal papillomatosis 11.4
4 papilloma 10.8
5 squamous cell carcinoma 10.4
6 limbic encephalitis with lgi1 antibodies 10.2 HLA-DQB1 HLA-DRB1
7 narcolepsy 2 10.2 HLA-DQB1 HLA-DRB1
8 autoimmune polyglandular syndrome type 3 10.2 HLA-DQB1 HLA-DRB1
9 hypersomnia 10.2 HLA-DQB1 HLA-DRB1
10 metal allergy 10.2 HLA-DQB1 HLA-DRB1
11 lichen planopilaris 10.2 HLA-DQB1 HLA-DRB1
12 type ii mixed cryoglobulinemia 10.2 HLA-DQB1 HLA-DRB1
13 beryllium disease 10.2 HLA-DQB1 HLA-DRB1
14 narcolepsy 1 10.2 HLA-DQB1 HLA-DRB1
15 chronic beryllium disease 10.2 HLA-DQB1 HLA-DRB1
16 lichen sclerosus 10.2 HLA-DQB1 HLA-DRB1
17 whipple disease 10.2 HLA-DQB1 HLA-DRB1
18 pityriasis rosea 10.2 HLA-DQB1 HLA-DRB1
19 pediatric multiple sclerosis 10.2 HLA-DQB1 HLA-DRB1
20 osteonecrosis of the jaw 10.2 HLA-DQB1 HLA-DRB1
21 idiopathic bronchiectasis 10.2 HLA-DQB1 HLA-DRB1
22 berylliosis 10.1 HLA-DRB1 IL2
23 acute disseminated encephalomyelitis 10.1 HLA-DQB1 HLA-DRB1
24 oligoarticular juvenile idiopathic arthritis 10.1 HLA-DQB1 HLA-DRB1
25 glaucomatocyclitic crisis 10.1 HLA-DQB1 HLA-DRB1
26 panuveitis 10.1 HLA-DQB1 HLA-DRB1
27 pure red-cell aplasia 10.1 HLA-DRB1 IL2
28 ocular cicatricial pemphigoid 10.1 HLA-DQB1 HLA-DRB1
29 focal epithelial hyperplasia 10.1 HLA-DQB1 HLA-DRB1
30 limited scleroderma 10.1 HLA-DRB1 IL2
31 paraneoplastic pemphigus 10.1 HLA-DQB1 HLA-DRB1
32 rheumatic fever 10.1 HLA-DRB1 IL2
33 vogt-koyanagi-harada disease 10.1 HLA-DQB1 HLA-DRB1
34 leprosy 3 10.1 HLA-DRB1 IL2
35 autoimmune gastritis 10.1 EGFR IL2
36 actinic prurigo 10.1 HLA-DRB1 IL13
37 gastroesophageal reflux 10.1
38 asthma 10.1
39 aspergillosis 10.1
40 measles 10.1
41 latex allergy 10.1 HLA-DQB1 IL13
42 autoimmune disease of central nervous system 10.1 HLA-DRB1 IL2
43 exanthem 10.1 EGFR IL2
44 angiostrongyliasis 10.1 IL13 IL2
45 epidermodysplasia verruciformis 10.0
46 polycythemia vera 10.0
47 retinitis pigmentosa 10.0
48 autoimmune disease of the nervous system 10.0 HLA-DRB1 IL2
49 stevens-johnson syndrome/toxic epidermal necrolysis 10.0 IL13 IL2
50 onchocerciasis 10.0 IL13 IL2

Graphical network of the top 20 diseases related to Recurrent Respiratory Papillomatosis:



Diseases related to Recurrent Respiratory Papillomatosis

Symptoms & Phenotypes for Recurrent Respiratory Papillomatosis

MGI Mouse Phenotypes related to Recurrent Respiratory Papillomatosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.93 EGFR HLA-DQB1 IL13 IL2 PTGS2 RAC1
2 endocrine/exocrine gland MP:0005379 9.88 EGFR HLA-DQB1 IL13 IL2 PTGS2 RAC1
3 growth/size/body region MP:0005378 9.85 EGFR HLA-DQB1 IL13 IL2 PTGS2 RAC1
4 digestive/alimentary MP:0005381 9.83 EGFR HLA-DQB1 IL13 IL2 PTGS2
5 hematopoietic system MP:0005397 9.8 EGFR HLA-DQB1 IL13 IL2 PTGS2 RAC1
6 immune system MP:0005387 9.73 EGFR HLA-DQB1 IL13 IL2 PTGS2 RAC1
7 muscle MP:0005369 9.55 EGFR HLA-DQB1 IL13 PTGS2 RAC1
8 reproductive system MP:0005389 9.43 EGFR HLA-DQB1 IL13 IL2 PTGS2 RAC1
9 respiratory system MP:0005388 9.02 EGFR HLA-DQB1 IL13 IL2 PTGS2

Drugs & Therapeutics for Recurrent Respiratory Papillomatosis

Drugs for Recurrent Respiratory Papillomatosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cidofovir Approved Phase 4,Phase 2 113852-37-2 60613
2 Antiviral Agents Phase 4,Phase 3,Phase 2
3 Anti-Infective Agents Phase 4,Phase 2
4 Immunologic Factors Phase 3,Phase 2,Early Phase 1
5 Vaccines Phase 3,Early Phase 1
6 Antibodies Phase 3,Phase 2
7 Immunoglobulins Phase 3,Phase 2
8
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
9
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
10
Pembrolizumab Approved Phase 2 1374853-91-4
11
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
12 Retinol palmitate Phase 2
13 retinol Phase 2
14 Angiogenesis Modulating Agents Phase 2,Phase 1
15 Pharmaceutical Solutions Phase 2
16 Angiogenesis Inhibitors Phase 2,Phase 1
17 Antirheumatic Agents Phase 2
18 Anti-Inflammatory Agents, Non-Steroidal Phase 2
19 Anti-Inflammatory Agents Phase 2
20 Cyclooxygenase Inhibitors Phase 2
21 Cyclooxygenase 2 Inhibitors Phase 2
22 Analgesics Phase 2
23 Peripheral Nervous System Agents Phase 2
24 Analgesics, Non-Narcotic Phase 2
25 Antibodies, Monoclonal Phase 2
26
Ergocalciferol Approved, Nutraceutical Phase 1 50-14-6 5280793
27
Vitamin D Approved, Nutraceutical, Vet_approved Phase 1 1406-16-2
28 Calciferol Phase 1
29 Vitamin D2 Phase 1
30 Micronutrients Phase 1
31 Bone Density Conservation Agents Phase 1
32 Vitamins Phase 1
33 Ergocalciferols Phase 1
34 Trace Elements Phase 1
35
3,3'-diindolylmethane Investigational Not Applicable 1968-05-4
36 Pepsin A Not Applicable
37 Protective Agents Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Use of Cidofovir for Recurrent Respiratory Papillomatosis Completed NCT00205374 Phase 4 Cidofovir;Placebo
2 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
3 4-valent HPV Vaccine to Treat Recurrent Respiratory Papillomatosis in Children Unknown status NCT01995721 Phase 3
4 Effect of Vaccination in Patients With Recurrent Respiratory Papillomatosis Completed NCT01375868 Phase 3
5 Propranolol Administration in Pediatric Patients With Recurrent Respiratory Papillomatosis Withdrawn NCT01058317 Phase 2, Phase 3 Propranolol
6 Bevacizumab Versus Cidofovir for the Treatment of Recurrent Respiratory Papillomatosis Unknown status NCT02555800 Phase 2 Bevacizumab;Cidofovir
7 Study of Celebrex (Celecoxib) in Patients With Recurrent Respiratory Papillomatosis Completed NCT00571701 Phase 2 celebrex (celecoxib);placebo
8 A Trial Study of SGN-00101 in Treating Pediatric Patients With Recurrent Respiratory Papillomatosis Completed NCT00038714 Phase 2 SGN-00101
9 M7824 in People With Recurrent Respiratory Papillomatosis Recruiting NCT03707587 Phase 2 M7824
10 Pembrolizumab for HPV-associated Recurrent Respiratory Papilloma Patients With Laryngeal, Tracheal and/or Pulmonary Involvement Recruiting NCT02632344 Phase 2 Pembrolizumab
11 Avelumab for People With Recurrent Respiratory Papillomatosis Active, not recruiting NCT02859454 Phase 2 Avelumab
12 Safety Study of EF-022 in Adults With Recurrent Respiratory Papillomatosis (RRP) Unknown status NCT02854761 Phase 1 EF-022 (Modified Vitamin D Binding Protein Macrophage Activator)
13 Bevacizumab for Treatment of Recurrent Respiratory Papillomatosis (RRP) Completed NCT01020747 Phase 1 Avastin® (bevacizumab);Saline
14 Multi-Center, Randomized Trial of the Pulsed Dye Laser for JORRP Completed NCT00550914
15 Human Papillomatosis Genotyping of Children in Thailand Completed NCT01304966
16 Human Papillomavirus 6/11 in the Lower Airway of Neonates Completed NCT00549250
17 Value of Narrow Band Imaging (NBI) Endoscopy in the Early Diagnosis of Laryngeal Cancer and Precancerous Lesions Completed NCT02217358 Not Applicable
18 Recurrent Respiratory Papillomatosis and Extraesophageal Reflux Recruiting NCT02592902 Not Applicable
19 Airway Intervention Registry (AIR): Recurrent Respiratory Papillomatosis (RRP) Recruiting NCT03465280
20 New Therapy of Laryngeal Papilloma In Children Terminated NCT00591305 Not Applicable
21 Therapeutic Treatment With Human Papillomavirus Quadrivalent Vaccine for Recurrent Respiratory Papillomatosis Withdrawn NCT00829608 Early Phase 1
22 Optical Coherence Tomography of the Airway for Lung Cancer or Lung Disease Withdrawn NCT00733252

Search NIH Clinical Center for Recurrent Respiratory Papillomatosis

Genetic Tests for Recurrent Respiratory Papillomatosis

Anatomical Context for Recurrent Respiratory Papillomatosis

MalaCards organs/tissues related to Recurrent Respiratory Papillomatosis:

41
Lung, Testes, T Cells, Spinal Cord, Endothelial, Bone, Tongue

Publications for Recurrent Respiratory Papillomatosis

Articles related to Recurrent Respiratory Papillomatosis:

(show top 50) (show all 432)
# Title Authors Year
1
Human papillomavirus types causing recurrent respiratory papillomatosis in Zimbabwe. ( 30554686 )
2019
2
Recurrent respiratory papillomatosis. ( 29800325 )
2018
3
Development of Human-Derived Cell Culture Lines for Recurrent Respiratory Papillomatosis. ( 29759030 )
2018
4
A Prospective Study of the Incidence of Juvenile-Onset Recurrent Respiratory Papillomatosis After Implementation of a National HPV Vaccination Program. ( 29136168 )
2018
5
Squamous Cell Papillomatosis in the Setting of Recurrent Respiratory Papillomatosis. ( 29594918 )
2018
6
Clinical and sociodemographic characteristics associated with disease severity in juvenile recurrent respiratory papillomatosis: A study of 104 patients in a tertiary care pediatric hospital. ( 29605367 )
2018
7
Reply to Fernandez-Bussy et al.: Recurrent Respiratory Papillomatosis and Bevacizumab Treatment. ( 28968137 )
2018
8
Current and future management of recurrent respiratory papillomatosis. ( 29492465 )
2018
9
Juvenile-Onset Recurrent Respiratory Papillomatosis: The Benefits of Quadrivalent Human Papillomavirus Vaccination Continue to Accrue. ( 29136167 )
2018
10
A retrospective case control analysis of the efficacy of Gardasil<sup>Ar</sup>vaccination in 28 patients with recurrent respiratory papillomatosis of the larynx. ( 29380936 )
2018
11
Hemoptysis in recurrent respiratory papillomatosis: also think about aspergillosis. ( 30043893 )
2018
12
Laryngeal reconstruction in children with recurrent respiratory papillomatosis. ( 30368371 )
2018
13
Recurrent respiratory papillomatosis with lung involvement. ( 30406011 )
2018
14
Recurrent Respiratory Papillomatosis. ( 30422770 )
2018
15
Risk factors for severity of juvenile-onset recurrent respiratory papillomatosis at first endoscopy. ( 30503689 )
2018
16
Transformation of Recurrent Respiratory Papillomatosis: Squamous Cell Carcinoma in a Pregnant Teen. ( 30508534 )
2018
17
Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1: Potential markers for malignant transformation of recurrent respiratory papillomatosis and for prognosis of laryngeal cancer. ( 30549356 )
2018
18
Recurrent Respiratory Papillomatosis and Bevacizumab Treatment. ( 28968150 )
2018
19
HPV vaccination as preventive approach for recurrent respiratory papillomatosis - a 22-year retrospective clinical analysis. ( 30041619 )
2018
20
Utility of Optical Coherence Tomography for Guiding Laser Therapy Among Patients With Recurrent Respiratory Papillomatosis. ( 30098151 )
2018
21
Juvenile-onset recurrent respiratory papillomatosis with pulmonary involvement and carcinomatous transformation. ( 30101139 )
2018
22
Outcomes of bevacizumab and cidofovir treatment in HPV-associated recurrent respiratory papillomatosis - review of the literature. ( 30190442 )
2018
23
Safety and Immunogenicity of a Nonadjuvant Human Papillomavirus Type 6 Virus-like Particle Vaccine in Recurrent Respiratory Papillomatosis. ( 30224308 )
2018
24
Recurrent respiratory papillomatosis: update 2018. ( 30300210 )
2018
25
Recurrent respiratory papillomatosis: the role of cidofovir. ( 30302253 )
2018
26
Therapeutic use of the HPV vaccine on recurrent respiratory papillomatosis: a systematic review and meta-analysis. ( 30358875 )
2018
27
PD-L1 expression and CD8+ infiltration shows heterogeneity in juvenile recurrent respiratory papillomatosis. ( 28576522 )
2017
28
The PD-1 and PD-L1 pathway in recurrent respiratory papillomatosis. ( 28940446 )
2017
29
Human Papillomavirus (HPV) Genotype Distribution in Patients with Recurrent Respiratory Papillomatosis (RRP) in Iran ( 28749631 )
2017
30
A case of video-assisted thoracoscopic resection of malignant transformation of pulmonary recurrent respiratory papillomatosis. ( 28523179 )
2017
31
Treatment With Quadrivalent Human Papillomavirus Vaccine for Juvenile-Onset Recurrent Respiratory Papillomatosis: Case Report and Review of the Literature. ( 28992265 )
2017
32
Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients. ( 28298239 )
2017
33
Quality and readability assessment of websites related to recurrent respiratory papillomatosis. ( 28233911 )
2017
34
HLA-DRB1 and HLA-DQB1 alleles in Chinese Han patients with Juvenile-Onset recurrent respiratory papillomatosis. ( 29106857 )
2017
35
Recurrent respiratory papillomatosis: A state-of-the-art review. ( 28427542 )
2017
36
Recurrent respiratory papillomatosis in a parturient presenting for cesarean delivery. ( 28347573 )
2017
37
Therapeutic use of the HPV vaccine in Recurrent Respiratory Papillomatosis: A case report. ( 28109479 )
2017
38
Treatment outcomes of recurrent respiratory papillomatosis : Retrospective analysis of juvenile and adult cases. ( 28840259 )
2017
39
Lymphocyte profile and cytokine mRNA expression in peripheral blood mononuclear cells of patients with recurrent respiratory papillomatosis suggest dysregulated cytokine mRNA response and impaired cytotoxic capacity. ( 28805308 )
2017
40
Comparison of cidofovir and the measles, mumps, and rubella vaccine in the treatment of recurrent respiratory papillomatosis. ( 28231366 )
2017
41
Quality of life of young patients with recurrent respiratory papillomatosis. ( 28193306 )
2017
42
Pegylated interferon for treating severe recurrent respiratory papillomatosis in a child: case report. ( 28977096 )
2017
43
Recurrent Respiratory Papillomatosis, more than two entities. ( 29293985 )
2017
44
Recurrent respiratory papillomatosis with lung and chest wall involvement: A rare complication in an adolescent. ( 28233516 )
2017
45
In-office vs. operating room procedures for recurrent respiratory papillomatosis. ( 28489241 )
2017
46
Systemic Bevacizumab for Recurrent Respiratory Papillomatosis: A Single Center Experience of Two Cases. ( 28757601 )
2017
47
Enhanced TH2-like peripheral adaptive immune responses in Juvenile-onset Recurrent Respiratory Papillomatosis (JORRP). ( 28860041 )
2017
48
Systemic bevacizumab for recurrent respiratory papillomatosis: A national survey. ( 28657692 )
2017
49
Laryngeal distribution of recurrent respiratory papillomatosis in a previously untreated cohort. ( 28714564 )
2017
50
Age of diagnosis, incidence and prevalence of recurrent respiratory papillomatosis-A South African perspective. ( 29054106 )
2017

Variations for Recurrent Respiratory Papillomatosis

Expression for Recurrent Respiratory Papillomatosis

Search GEO for disease gene expression data for Recurrent Respiratory Papillomatosis.

Pathways for Recurrent Respiratory Papillomatosis

Pathways related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 EGFR HLA-DQB1 HLA-DRB1 IL13 IL2 PTGS2
2
Show member pathways
13.44 EGFR IL13 IL2 PTGS2 RAC1
3
Show member pathways
13.41 EGFR HLA-DQB1 HLA-DRB1 IL2 PTGS2 RAC1
4
Show member pathways
12.99 EGFR HLA-DQB1 HLA-DRB1 IL13 IL2 PTGS2
5
Show member pathways
12.92 EGFR HLA-DQB1 HLA-DRB1 IL2 RAC1
6
Show member pathways
12.83 EGFR IL2 PTGS2 RAC1
7
Show member pathways
12.77 EGFR HLA-DQB1 HLA-DRB1 RAC1
8
Show member pathways
12.77 EGFR IL2 PTGS2 RAC1
9
Show member pathways
12.68 HLA-DQB1 HLA-DRB1 PTGS2 RAC1
10
Show member pathways
12.57 HLA-DQB1 HLA-DRB1 IL13 IL2 RAC1
11
Show member pathways
12.56 HLA-DQB1 HLA-DRB1 IL13 IL2
12 12.44 EGFR IL13 IL2 PTGS2 RAC1
13
Show member pathways
12.4 EGFR IL2 RAC1
14
Show member pathways
12.39 IL13 PTGS2 RAC1
15
Show member pathways
12.37 HLA-DQB1 HLA-DRB1 IL2 RAC1
16
Show member pathways
12.33 HLA-DQB1 HLA-DRB1 IL13 IL2
17
Show member pathways
12.26 EGFR IL13 IL2
18 12.24 HLA-DQB1 HLA-DRB1 IL2
19
Show member pathways
12.2 EGFR IL13 IL2
20
Show member pathways
12.14 EGFR PTGS2 RAC1
21
Show member pathways
12.14 HLA-DQB1 HLA-DRB1 IL2 RAC1
22 12.11 HLA-DQB1 HLA-DRB1 RAC1
23
Show member pathways
12.08 EGFR IL13 IL2
24
Show member pathways
12.06 HLA-DQB1 HLA-DRB1 PTGS2
25
Show member pathways
12.01 HLA-DQB1 HLA-DRB1 RAC1
26 11.93 HLA-DQB1 HLA-DRB1 RAC1
27
Show member pathways
11.89 EGFR IL13 IL2
28
Show member pathways
11.82 EGFR IL13 IL2
29
Show member pathways
11.63 EGFR HLA-DQB1 HLA-DRB1 RAC1
30 11.53 EGFR IL2 RAC1
31
Show member pathways
11.51 IL2 PTGS2
32 11.5 IL13 IL2 PTGS2
33 11.46 EGFR RAC1
34 11.45 HLA-DQB1 HLA-DRB1
35 11.4 PTGS2 RAC1
36 11.4 EGFR IL2
37 11.39 HLA-DQB1 HLA-DRB1 RAC1
38 11.37 IL13 PTGS2
39 11.36 EGFR PTGS2
40 11.36 EGFR IL2
41 11.34 IL13 IL2
42 11.32 EGFR RAC1
43 11.24 EGFR HLA-DQB1 HLA-DRB1 RAC1
44 11.06 IL13 IL2
45 11 EGFR IL2 PTGS2 RAC1
46 10.94 EGFR RAC1
47 10.9 HLA-DRB1 IL13 IL2
48 10.88 EGFR RAC1
49 10.79 EGFR IL13 IL2 RAC1
50 10.78 HLA-DRB1 IL13 IL2

GO Terms for Recurrent Respiratory Papillomatosis

Cellular components related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum membrane GO:0005789 9.67 EGFR HLA-DRB1 PTGS2 RAC1
2 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-DQB1 HLA-DRB1
3 transport vesicle membrane GO:0030658 9.4 HLA-DQB1 HLA-DRB1
4 endosome membrane GO:0010008 9.33 EGFR HLA-DQB1 HLA-DRB1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.32 HLA-DQB1 HLA-DRB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-DQB1 HLA-DRB1
7 MHC class II protein complex GO:0042613 8.96 HLA-DQB1 HLA-DRB1
8 Golgi membrane GO:0000139 8.92 EGFR HLA-DQB1 HLA-DRB1 RAC1

Biological processes related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.71 IL13 PTGS2 RAC1
2 cytokine-mediated signaling pathway GO:0019221 9.67 IL13 IL2 PTGS2
3 immune response GO:0006955 9.62 HLA-DQB1 HLA-DRB1 IL13 IL2
4 positive regulation of protein phosphorylation GO:0001934 9.58 EGFR IL2 RAC1
5 antigen processing and presentation GO:0019882 9.52 HLA-DQB1 HLA-DRB1
6 positive regulation of B cell proliferation GO:0030890 9.51 IL13 IL2
7 positive regulation of vasoconstriction GO:0045907 9.48 EGFR PTGS2
8 positive regulation of DNA replication GO:0045740 9.46 EGFR RAC1
9 positive regulation of synaptic transmission, glutamatergic GO:0051968 9.43 EGFR PTGS2
10 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.37 HLA-DQB1 HLA-DRB1
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.33 EGFR IL13 PTGS2
12 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.26 HLA-DQB1 HLA-DRB1
13 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.96 HLA-DQB1 HLA-DRB1
14 cellular response to mechanical stimulus GO:0071260 8.92 EGFR IL13 PTGS2 RAC1

Molecular functions related to Recurrent Respiratory Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.33 EGFR PTGS2 RAC1
2 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
3 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Recurrent Respiratory Papillomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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