MCID: RDC010
MIFTS: 28

Reducing Body Myopathy

Categories: Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Reducing Body Myopathy

MalaCards integrated aliases for Reducing Body Myopathy:

Name: Reducing Body Myopathy 12 53 59 37 15
Myopathy, Reducing Body 40
Reducing-Body Myopathy 72

Characteristics:

Orphanet epidemiological data:

59
reducing body myopathy
Inheritance: Not applicable,X-linked dominant; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult,Childhood,Infancy; Age of death: early childhood;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:0080090
KEGG 37 H00657
ICD10 via Orphanet 34 G71.2
UMLS via Orphanet 73 C0270970
Orphanet 59 ORPHA97239
UMLS 72 C0270970

Summaries for Reducing Body Myopathy

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 97239DefinitionReducing body myopathy (RBM) is a rare muscle disorder marked by progressive muscle weakness and the presence of characteristic inclusion bodies in affected muscle fibres.EpidemiologyThe prevalence is unknown: although some sporadic cases have been described, only four families with RBM have been reported in the literature so far.Clinical descriptionThe age of onset, speed of progression and severity of the disease vary significantly between patients, even between affected members of the same family. Although early development is generally normal (up to 2 years of age), onset during infancy or early childhood appears to be associated with severe myopathy, hypotonia and rapidly progressive muscle weakness leading to death due to respiratory insufficiency within the first five years of life. Onset during childhood or adulthood is characterised by mainly proximal muscle weakness, a rigid spine syndrome and a slowly progressive disease course.EtiologyBoth sporadic and familial cases of RBM are caused by mutations in the gene encoding the four-and-a-half LIM domain 1 protein (FHL1; Xq27.2).Diagnostic methodsAs the clinical picture is highly variable (EMG reveals mixed myogenic patterns), diagnosis relies on recognition of the typical histopathological findings at muscle biopsy: the non-membrane-bound inclusions reduce nitro-blue tetrazolium (hence the name `reducing body myopathy') and are located in the cytoplasm, usually close to the degenerating nucleus. Electron microscopy reveals that the inclusions consist of a fine granular material and immunohistochemical analysis reveals the presence of aggresome-like proteins.Differential diagnosisThe differential diagnosis should include other disorders with reducing bodies (e.g. acid maltase deficiency) and other congenital myopathies in familial cases (see these terms). Sarcotubular myopathy may also be considered in patients with less severe forms of the disease.Genetic counselingThe mode of transmission remains unclear. There are no reports of male-to-male transmission in familial cases and cases of severely affected females have been reported. X-linked dominant, semi-dominant and recessive inheritance have been suggested and skewed X-inactivation has not been excluded.Management and treatmentManagement is supportive and should be multidisciplinary (involving a neurologist, orthopaedic surgeon and physical therapist).PrognosisThe prognosis is generally severe: disease progression results in loss of ambulation, and death due to respiratory failure occurs even in patients with later-onset slowly progressive forms of the disease.Visit the Orphanet disease page for more resources.

MalaCards based summary : Reducing Body Myopathy, also known as myopathy, reducing body, is related to myopathy and foot drop. An important gene associated with Reducing Body Myopathy is FHL1 (Four And A Half LIM Domains 1), and among its related pathways/superpathways are Cardiac conduction and Dilated cardiomyopathy (DCM). Affiliated tissues include skeletal muscle, and related phenotypes are muscle and vision/eye

KEGG : 37
Reducing body myopathy (RBM) is a rare, sometimes fatal, X-linked disorder characterized by progressive muscle weakness and the presence of intracytoplasmic aggregates in histological muscle sections which exert a reducing activity on nitro-blue tetrazolium (NBT) staining. The causative gene for RBM is FHL1 encoding four and a half LIM domains.

Related Diseases for Reducing Body Myopathy

Diseases related to Reducing Body Myopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 myopathy 30.5 TTN NEB FHL1
2 foot drop 30.2 NEB FHL1
3 neuromuscular disease 29.6 TTN DMD
4 myopathy, congenital 29.5 NEB DMD
5 rigid spine muscular dystrophy 1 29.5 TTN FHL1 DMD
6 hypertrophic cardiomyopathy 29.2 TTN FHL1
7 muscular disease 29.0 TTN NEB DMD
8 scapuloperoneal myopathy 28.9 MAP7D3 LIM2 FHL1
9 muscular dystrophy 28.9 TTN NEB FHL1 DMD
10 reducing body myopathy, x-linked 1a, severe, with infantile or early childhood onset 12.9
11 reducing body myopathy, x-linked 1b, with late childhood or adult onset 12.8
12 hemophagocytic lymphohistiocytosis, familial, 1 10.3
13 scoliosis 10.2
14 nemaline myopathy 2 10.1 TTN NEB
15 emery-dreifuss muscular dystrophy 10.1
16 muscular dystrophy, limb-girdle, autosomal recessive 7 10.0 TTN DMD
17 muscular dystrophy, limb-girdle, autosomal recessive 6 10.0 TTN DMD
18 familial isolated dilated cardiomyopathy 10.0 TTN DMD
19 centronuclear myopathy 10.0 TTN DMD
20 respiratory failure 10.0
21 hypotonia 10.0
22 intrinsic cardiomyopathy 10.0 TTN DMD
23 miyoshi muscular dystrophy 10.0 TTN DMD
24 muscular dystrophy, congenital, lmna-related 9.9 TTN DMD
25 muscle tissue disease 9.9 NEB DMD
26 myositis 9.9 TTN DMD
27 atrial standstill 1 9.8 TTN DMD
28 scapuloperoneal myopathy, x-linked dominant 9.8
29 orthostatic intolerance 9.8
30 mumps 9.8
31 dysphagia 9.8
32 left ventricular noncompaction 9.8 TTN DMD
33 limb-girdle muscular dystrophy 9.7 TTN DMD
34 arrhythmogenic right ventricular cardiomyopathy 9.6 TTN DMD
35 cardioneuromyopathy with hyaline masses and nemaline rods 9.6 TTN NEB DMD
36 myofibrillar myopathy 9.6 TTN NEB DMD

Graphical network of the top 20 diseases related to Reducing Body Myopathy:



Diseases related to Reducing Body Myopathy

Symptoms & Phenotypes for Reducing Body Myopathy

MGI Mouse Phenotypes related to Reducing Body Myopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.26 DMD FHL1 NEB TTN
2 vision/eye MP:0005391 8.92 DMD LIM2 NEB TTN

Drugs & Therapeutics for Reducing Body Myopathy

Search Clinical Trials , NIH Clinical Center for Reducing Body Myopathy

Genetic Tests for Reducing Body Myopathy

Anatomical Context for Reducing Body Myopathy

MalaCards organs/tissues related to Reducing Body Myopathy:

41
Skeletal Muscle

Publications for Reducing Body Myopathy

Articles related to Reducing Body Myopathy:

(show all 49)
# Title Authors PMID Year
1
Clinical, histological and genetic characterization of reducing body myopathy caused by mutations in FHL1. 38 71
19181672 2009
2
Novel FHL1 mutations in fatal and benign reducing body myopathy. 38 71
19171836 2009
3
Rigid spine syndrome caused by a novel mutation in four-and-a-half LIM domain 1 gene (FHL1). 38 71
18952429 2008
4
Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy. 38 71
18274675 2008
5
Familial reducing body myopathy. 38 71
16919903 2007
6
Fatal reducing body myopathy. Ultrastructural and immunohistochemical observations. 38 71
7722535 1995
7
FHL1-related clinical, muscle MRI and genetic features in six Chinese patients with reducing body myopathy. 38
31273321 2019
8
Concurrent positive anti-3-hydroxy-3-methylglutaryl-coenzyme a reductase antibody with reducing body myopathy: Possible double trouble. 38
31204143 2019
9
Gluteus maximus hypertrophy: A diagnostic clue in four and a half LIM domain 1-mutated reducing body myopathy. 38
28694073 2017
10
Muscle hypertrophy as the presenting sign in a patient with a complete FHL1 deletion. 38
27409453 2016
11
X-linked Recessive Distal Myopathy With Hypertrophic Cardiomyopathy Caused by a Novel Mutation in the FHL1 Gene. 38
25246303 2015
12
Necklace cytoplasmic bodies in hereditary myopathy with early respiratory failure. 38
25253871 2015
13
Fhl1 W122S causes loss of protein function and late-onset mild myopathy. 38
25274776 2015
14
A case of adult-onset reducing body myopathy presenting a novel clinical feature, asymmetrical involvement of the sternocleidomastoid and trapezius muscles. 38
24928078 2014
15
FHL1 mutants that cause clinically distinct human myopathies form protein aggregates and impair myoblast differentiation. 38
24634512 2014
16
Aggresome-Autophagy Involvement in a Sarcopenic Patient with Rigid Spine Syndrome and a p.C150R Mutation in FHL1 Gene. 38
25191266 2014
17
Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. 38
23975679 2014
18
Skeletal muscle biopsy analysis in reducing body myopathy and other FHL1-related disorders. 38
23965743 2013
19
[Myofibrillar myopaathy]. 38
24291893 2013
20
Novel FHL1 mutation in a family with reducing body myopathy. 38
23169582 2013
21
Selective muscle involvement in a family affected by a second LIM domain mutation of fhl1: an imaging study using computed tomography. 38
22541254 2012
22
Reducing body myopathy and other FHL1-related muscular disorders. 38
22172421 2011
23
Protein aggregation in congenital myopathies. 38
22172423 2011
24
Christianson syndrome in a patient with an interstitial Xq26.3 deletion. 38
21932316 2011
25
A study of FHL1, BAG3, MATR3, PTRF and TCAP in Australian muscular dystrophy patients. 38
21683594 2011
26
Four and a half LIM protein 1 gene mutations cause four distinct human myopathies: a comprehensive review of the clinical, histological and pathological features. 38
21310615 2011
27
Familial reducing body myopathy with cytoplasmic bodies and rigid spine revisited: identification of a second LIM domain mutation in FHL1. 38
20571991 2010
28
Muscle MRI in FHL1-linked reducing body myopathy. 38
19616434 2009
29
SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis. 38
19643733 2009
30
Consequences of mutations within the C terminus of the FHL1 gene. 38
19687455 2009
31
Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy. 38
19075112 2008
32
Unfolded protein response and aggresome formation in hereditary reducing-body myopathy. 38
17099882 2007
33
Delayed or late-onset type II glycogenosis with globular inclusions. 38
15986226 2005
34
Ultrastructural detection of DNA fragmentation in myonuclei of fatal reducing body myopathy. 38
14986028 2004
35
Nucleolar characteristics of reducing bodies in reducing body myopathy. 38
14735304 2004
36
Reducing body myopathy with cytoplasmic bodies and rigid spine syndrome: a mixed congenital myopathy. 38
11571700 2001
37
[Reducing body myopathy]. 38
11555975 2001
38
Adult onset reducing body myopathy. 38
10619716 1999
39
Familial mixed congenital myopathy with rigid spine phenotype. 38
9121497 1997
40
Reducing bodies in distal myopathy with rimmed vacuole formation. 38
7709723 1995
41
Reducing body myopathy and desmin storage in skeletal muscle: morphological and biochemical findings. 38
8140891 1994
42
A unique case of reducing body myopathy. 38
1314327 1992
43
[Reducing body myopathy--a case report]. 38
1321016 1992
44
New observations in reducing body myopathy. 38
4000482 1985
45
A benign form of reducing body myopathy. 38
6306460 1983
46
[Granular body myopathy (so-called reducing body myopathy)]. 38
7088899 1982
47
[Reducing body myopathy--ultrastructure and classification (author's transl)]. 38
6269277 1981
48
Congenital myopathy with "reducing bodies" in muscle fibres. 38
1138529 1975
49
Reducing body myopathy. 38
4117299 1972

Variations for Reducing Body Myopathy

Expression for Reducing Body Myopathy

Search GEO for disease gene expression data for Reducing Body Myopathy.

Pathways for Reducing Body Myopathy

GO Terms for Reducing Body Myopathy

Cellular components related to Reducing Body Myopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sarcomere GO:0030017 9.16 TTN NEB
2 myofibril GO:0030016 8.96 NEB DMD
3 Z disc GO:0030018 8.8 TTN NEB DMD

Biological processes related to Reducing Body Myopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cardiac muscle contraction GO:0060048 9.16 TTN DMD
2 muscle organ development GO:0007517 9.13 NEB FHL1 DMD
3 muscle filament sliding GO:0030049 8.8 TTN NEB DMD

Molecular functions related to Reducing Body Myopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of muscle GO:0008307 8.8 TTN NEB DMD

Sources for Reducing Body Myopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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