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MCID: RFL001
MIFTS: 50

Reflex Sympathetic Dystrophy

Categories: Neuronal diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Reflex Sympathetic Dystrophy

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MalaCards integrated aliases for Reflex Sympathetic Dystrophy:

Name: Reflex Sympathetic Dystrophy 57 11 58 53 43 14 16 71
Algodystrophy 58 53
Complex Regional Pain Syndrome Type 1 58
Reflex Sympathetic Dystrophy Syndrome 75
Complex Regional Pain Syndromes 71
Algodystrophic Syndrome 71

Characteristics:


Prevelance:

Complex Regional Pain Syndrome Type 1: 1-9/100000 (United States) 1-5/10000 (United States) 58

Age Of Onset:

Complex Regional Pain Syndrome Type 1: All ages 58

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Skin diseases
See all MalaCards categories (disease lists)
Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 11 DOID:1811
OMIM® 57 604335
ICD9CM 34 337.2
MeSH 43 D012019
NCIt 49 C85042
SNOMED-CT 68 203492008
ICD10 via Orphanet 32 G90.5
UMLS via Orphanet 72 C0034931 C1527353
Orphanet 58 ORPHA99995
UMLS 71 C0034931 C0458219 C1527353
Sources

Summaries for Reflex Sympathetic Dystrophy

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Orphanet: 58 Complex regional pain syndrome type 1 (CRPS1) is a form of complex regional pain syndrome (see this term) in which the pain is disproportionate to any known inciting event and is characterized by continuous pain, allodynia, or hyperalgesia as well as edema, coloration (changes in skin blood flow), or abnormal sudomotor activity in the region of pain. Onset of CRPS1 symptoms may occur within a few days to a month after an injury or trauma to the affected limb.

MalaCards based summary: Reflex Sympathetic Dystrophy, also known as algodystrophy, is related to algoneurodystrophy and complex regional pain syndrome, and has symptoms including tremor, back pain and headache. An important gene associated with Reflex Sympathetic Dystrophy is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are Neuroscience and Phase 0 - rapid depolarisation. The drugs Lidocaine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include dorsal root ganglion, spinal cord and skin, and related phenotypes are nervous system and behavior/neurological

Wikipedia: 75 Complex regional pain syndrome (CRPS) is any of several painful conditions that are characterized by a... more...

More information from OMIM: 604335
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Related Diseases for Reflex Sympathetic Dystrophy

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Diseases related to Reflex Sympathetic Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 340)
# Related Disease Score Top Affiliating Genes
1 algoneurodystrophy 32.8 TOR1B CALCA
2 complex regional pain syndrome 31.8 TRPV1 TAC1 SCN9A SCN11A NGF CALCA
3 causalgia 31.4 TRPV1 TAC1 SCN9A NGF CALCA
4 paine syndrome 30.4 TRPV1 TAC1 SCN9A SCN11A NGF CALCA
5 migraine with aura 30.1 TAC1 SCN9A CALCA
6 horner's syndrome 30.0 NGF CALCA
7 neuroma 30.0 TRPV1 NGF CALCA
8 diabetic autonomic neuropathy 30.0 TAC1 NGF
9 impotence 29.9 TAC1 NPY NGF
10 fibromyalgia 29.8 SCN9A NPY NGF CALCA ADRB2
11 frozen shoulder 29.8 TAC1 PARPBP CALCA
12 cystitis 29.8 TRPV1 TAC1 NGF
13 irritable bowel syndrome 29.8 TRPV1 TAC1 NGF
14 autonomic neuropathy 29.7 SCN11A NPY NGF
15 nerve compression syndrome 29.6 TRPV1 TAC1 NGF CALCA
16 interstitial cystitis 29.6 TRPV1 TAC1 NGF CALCA
17 pain agnosia 29.4 TRPV1 TAC1 SCN9A SCN11A NGF CALCA
18 erythromelalgia 29.4 TRPV1 TAC1 SCN9A SCN11A NGF
19 myofascial pain syndrome 29.2 TRPV1 TAC1 PARPBP NGF CALCA
20 anxiety 29.2 TRPV1 TAC1 NPY NGF GABRA3
21 autonomic nervous system disease 29.1 TRPV1 TAC1 SCN9A SCN11A NPY NGF
22 somatoform disorder 29.1 TRPV1 TAC1 SCN9A SCN11A NGF CALCA
23 diabetic neuropathy 28.9 TRPV1 TAC1 SCN9A SCN11A NGF CALCA
24 hypertension, essential 28.9 TRPV1 TAC1 NPY NGF CD36 CALCA
25 peripheral nervous system disease 28.7 TRPV1 TAC1 SCN9A SCN11A NPY NGF
26 migraine with or without aura 1 28.4 TRPV1 TAC1 SCN9A SCN11A NPY NGF
27 dysautonomia 11.3
28 chronic pain 10.6
29 hemiplegia 10.5
30 dystonia 10.5
31 temtamy preaxial brachydactyly syndrome 10.4
32 tremor 10.4
33 carpal tunnel syndrome 10.4
34 radiculopathy 10.4
35 herpes zoster 10.4
36 neuropathy 10.4
37 spinal cord injury 10.4
38 spondyloarthropathy 1 10.3
39 osteoporosis 10.3
40 hypoascorbemia 10.3
41 osteomalacia 10.3
42 conversion disorder 10.3
43 stroke, ischemic 10.3
44 cone-rod dystrophy 2 10.3
45 bone mineral density quantitative trait locus 8 10.3
46 bone mineral density quantitative trait locus 15 10.3
47 focal dystonia 10.3
48 quadriplegia 10.3
49 spinal cord disease 10.3
50 movement disease 10.3

Graphical network of the top 20 diseases related to Reflex Sympathetic Dystrophy:



Diseases related to Reflex Sympathetic Dystrophy
Sources

Symptoms & Phenotypes for Reflex Sympathetic Dystrophy

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Clinical features from OMIM®:

604335 (Updated 08-Dec-2022)

UMLS symptoms related to Reflex Sympathetic Dystrophy:


tremor; back pain; headache; syncope; pain; chronic pain; sciatica; seizures; vertigo/dizziness; sleeplessness; neuralgia

MGI Mouse Phenotypes related to Reflex Sympathetic Dystrophy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.02 ADRB2 CALCA CD36 GABRA3 NGF NPY
2 behavior/neurological MP:0005386 9.9 ADRB2 CALCA CD36 GABRA3 NGF NPY
3 renal/urinary system MP:0005367 9.8 ADRB2 CALCA CD36 NPY SCN9A TAC1
4 integument MP:0010771 9.23 ADRB2 CALCA CD36 NGF SCN11A SCN9A
5 taste/olfaction MP:0005394 9.13 CD36 SCN9A TRPV1
Sources

Drugs & Therapeutics for Reflex Sympathetic Dystrophy

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Drugs for Reflex Sympathetic Dystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
3 Anti-Arrhythmia Agents Phase 4
4 Sodium Channel Blockers Phase 4
5 Diuretics, Potassium Sparing Phase 4
6 Pharmaceutical Solutions Phase 4
7
Triamcinolone hexacetonide Phase 4
8
Triamcinolone diacetate Phase 4
9
Triamcinolone Acetonide Phase 4 6436
10 Hormone Antagonists Phase 4
11 Potassium phosphate Phase 4
12 glucocorticoids Phase 4
13 Immunosuppressive Agents Phase 4
14
Zoledronic acid Approved Phase 3 118072-93-8 68740
15
Ropivacaine Approved Phase 3 84057-95-4 71273 175805
16
Bupivacaine Approved, Investigational Phase 3 2180-92-9, 38396-39-3 2474
17
Levobupivacaine Approved, Investigational Phase 3 27262-47-1 92253
18
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
19
Nitrous oxide Approved, Vet_approved Phase 3 10024-97-2 948
20
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 3 55-56-1 2713 9552079
21
Ascorbic acid Approved, Nutraceutical Phase 3 50-81-7 54676860 54670067 5785
22
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 22737-96-8, 68-26-8 5280382 445354
23
Imidacloprid Vet_approved Phase 3 105827-78-9 86418
24 Diphosphonates Phase 3
25 Anesthetics, Intravenous Phase 3
26 Vitamins Phase 3
27 Trace Elements Phase 3
28 Antioxidants Phase 3
29 Micronutrients Phase 3
30 Anesthetics, General Phase 3
31 Anesthetics, Inhalation Phase 3
32 Retinol palmitate Phase 3
33 Chlorhexidine gluconate Phase 3
34
Dronabinol Approved, Illicit Phase 2 1972-08-3 16078
35
Midazolam Approved, Illicit Phase 2 59467-70-8 4192
36
Cetuximab Approved Phase 2 205923-56-4
37
Ketamine Approved, Vet_approved Phase 2 6740-88-1, 1867-66-9 3821
38
Ethosuximide Approved Phase 2 77-67-8 3291
39
Lenalidomide Approved Phase 2 191732-72-6 216326
40 Hallucinogens Phase 2
41 Antineoplastic Agents, Immunological Phase 2
42 Anesthetics, Dissociative Phase 2
43 Anticonvulsants Phase 2
44 Angiogenesis Inhibitors Phase 2
45 Adjuvants, Immunologic Phase 2
46 Neurotropin Phase 2
47
Diclofenac Approved, Vet_approved 15307-86-5, 15307-79-6 3033
48
Acetylcholine Approved, Investigational 51-84-3 187
49
Acetaminophen Approved 103-90-2 1983
50
Capsaicin Approved 404-86-4 1548943

Interventional clinical trials:

(show top 50) (show all 139)
# Name Status NCT ID Phase Drugs
1 Prophylactic Administration of Vitamin C in Wrist Fractures; a Randomized Placebo Controlled Multicentre Dose-Finding Study of the Incidence of Complex Regional Pain Syndrome Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
2 Assessing the Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome - a Feasibility Study Completed NCT03291197 Phase 4 Suprascapular and median nerve blocks
3 Single Blinded, Randomized Control Trial of High Frequency Stimulation in Subjects With Precision® Spinal Cord Stimulator System to Assess Efficacy and Preferability in Back and Extremity Pain Relief Completed NCT02265848 Phase 4
4 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
5 Restore Claims Characterization Study Completed NCT00200122 Phase 4
6 Peripheral Nerve Injections for the Treatment of Upper Extremity Complex Regional Pain Syndrome: A Feasibility Study for a Proposed Randomized Design Not yet recruiting NCT04744675 Phase 4 Triamcinolone Acetonide 40mg/mL;Saline Injection
7 CREATE-1 Study: CRPS Treatment Evaluation 1 Study. A Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of AXS-02 (Oral Zoledronate) Administered Orally to Subjects With Complex Regional Pain Syndrome Type I (CRPS-I) Unknown status NCT02504008 Phase 3 AXS-02 (oral zoledronate);Placebo
8 Acupuncture and Traditional Chinese Medicine Combined With Rehabilitation Therapy for Post-stroke Shoulder-hand Syndrome in Community Hospital: a Multicenter，Randomized，Controlled Trial Unknown status NCT02011854 Phase 2, Phase 3
9 Double-Blind Randomized Controlled Trial: Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
10 An Analysis of Photoplethysmographic Signal in Diagnostic Lumbar Sympathetic Block for Complex Regional Pain Syndrome Unknown status NCT01134289 Phase 3
11 Surgical Treatment of Complex Regional Pain Syndrome Type II (CRPS II) by Regional Subcutaneous Venous Sympathectomy Unknown status NCT01392599 Phase 3
12 Pain Exposure Physical Therapy Or Conservative Therapy for Patients With Complex Regional Pain Syndrome Type I Completed NCT00817128 Phase 2, Phase 3
13 Open-label Safety Trial of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Completed NCT02972359 Phase 3 Neridronic acid
14 Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidamide in the Treatment of Complex Regional Pain Syndrome Type1 Completed NCT00166452 Phase 3 Lenalidamide
15 A Randomized, Double-blind Trial Investigating the Efficacy and Safety of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome Type I (CRPS-I) Completed NCT02402530 Phase 2, Phase 3 Placebo;Neridronic acid 62.5 mg
16 A Verification Study of JNS020QD in Patients With Post-herpetic Neuralgia, Complex Regional Pain Syndrome (CRPS) or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
17 Pilot Study to Evaluate the Effectiveness of a Mixture of Ketamine / Lidocaine Administered by Mesotherapy in the Management of Neuropathic Pain in Complex Regional Pain Syndrome Type 1 (CRPS1). A Monocentric Randomized and Controlled Clinical Study Recruiting NCT04650074 Phase 2, Phase 3 LIDOCAINE 20 mg;LIDOCAINE 20 mg + KETAMINE 20 mg;LIDOCAINE 20 mg + KETAMINE 40 mg
18 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Recruiting NCT02390505 Phase 3 Vitamin C;Placebo
19 A Prospective Randomized Controlled Pilot Study Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome Enrolling by invitation NCT03879538 Phase 3 Nitrous Oxide;Oxygen
20 A Novel Treatment Approach to Complex Regional Pain Syndrome (CRPS): A Feasibility Study of Combined Peripheral Nerve Block and Physiotherapy Not yet recruiting NCT05589259 Phase 3
21 Placebo-controlled Efficacy and Safety Trial of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Terminated NCT03560986 Phase 3 Neridronic acid 100 mg;Placebo
22 Randomized, Double-blind, Placebo-controlled Trial Investigating the Efficacy and Safety of Intravenous Neridronic Acid in Subjects With Complex Regional Pain Syndrome (CRPS) Terminated NCT03530345 Phase 3 Neridronic acid 100 mg;Placebo
23 Prospective, Double-blind, Randomised, Placebo-controlled, Cross-over Study to Investigate the Effect of Intravenous Immunoglobulins on Complex Regional Pain Syndrome (CRPS, M. Sudeck) Withdrawn NCT00949065 Phase 3
24 Low Dose Administration of Delta9-Tetrahydrocannabinol for the Prevention of Hyperalgesia and Chronic Pain in Patients With Acute Complex Regional Pain Syndrome (CRPS) of the Upper Limb Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol
25 Phase 2 Study - The Use of a Single 5 mg Dose of Zoledronic Acid in Complex Regional Pain Syndrome Patient. Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
26 CCRC: The Analgesic Effect of Vaporized Cannabis on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2 Mild dose cannabis;Low dose cannabis;Cannabis
27 A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 as an Adjunctive Therapy in Adult Subjects With Chronic Complex Regional Pain Syndrome Completed NCT03990649 Phase 2 Soticlestat;Placebo
28 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2 Ketamine
29 A Multicenter, Open-Label Study to Evaluate the Preliminary Safety and Efficacy of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2 Lenalidomide
30 A Randomized, Cross-over, Placebo-controlled, Double-blind, Single-center, Phase II Study of Cetuximab in Patients With Treatment-refractory, Non-malignant Severe Chronic Neuropathic Pain Completed NCT02490436 Phase 2 Cetuximab;Placebo
31 Randomized Controlled Trial of Subanesthetic Intravenous Ketamine Infusion in Conjunction With Continuous Epidural Infusion for Treatment of Refractory Complex Regional Pain Syndrome Terminated NCT02094352 Phase 2 Ketamine Infusion + Epidural Infusion;Control Group + Epidural infusion;Ketamine Booster Infusion;Control Group Booster Infusion
32 A Single Centre. Parallel-Group, Double-Blinded, Randomized, Placebo-Controlled Pilot Clinical Trial on Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS) Terminated NCT00689585 Phase 2 Placebo;Ethosuximide
33 A Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1 Terminated NCT00109772 Phase 2 lenalidomide;Placebo
34 Neurotropin for Acute Dental Pain and for Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
35 Use of Autologous Adult Adipose-Derived Stem/Stromal Cells in Reflex Sympathetic Dystrophy (RSD), Complex Regional Pain Syndrome (CRPS), and Fibromyalgia Withdrawn NCT02987855 Phase 1, Phase 2
36 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
37 Comparison of Two Measures of Tactile Acuity in CRPS Type I Patients , Patients With a Neuropathy of the Median Nerve and Healthy Controls. Unknown status NCT01888783
38 Treatment of Complex Regional Pain Syndrome, a Qualitative Interview Study and a Case Series With Long-term Follow-up Unknown status NCT04597866
39 Comparison of the Efficacy of the Ultrasound With Fluoroscopy in Guidance of Lumbar Sympathetic Block: A Prospective Randomized Open-label Trial Unknown status NCT02737527 10 ml of 0.25% levobupivacaine injection for LSB
40 Identifying Markers of Trajectory in Pediatric Complex Regional Pain Syndrome Unknown status NCT03838107
41 Comparison of Gait Parameters Between Floor and Sponge Surfaces and Special Shoes in Individuals With Difficulties in Weight-bearing Unknown status NCT02742376
42 Effects of Repetitive Electric Sensory Stimulation on Sensorimotor Performance and Pain Intensity in Complex Regional Pain Syndrome Type I Unknown status NCT01915329
43 Effects of Proprioceptive Stimulation Under Visual Feedback in Patient With CRPS: An Exploratory Study Unknown status NCT02395211
44 "Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome" Unknown status NCT03616262 Early Phase 1 Botox + Lidocaine;Lidocaine alone
45 EFFECTIVENESS OF GRADED MOTOR IMAGERY TO PREVENT CRPS IN PATIENTS WITH DISTAL RADIUS FRACTURE AFTER SURGERY: A RANDOMIZED CONTROLLED TRIAL Unknown status NCT03937492
46 The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture, Prospective Double Blind Study Unknown status NCT01338129 placebo
47 Investigation of the Efficacy of Transcranial Direct Current Stimulation (tDCS) Added to the Graded Motor Imagery (GMI) in the Treatment of Complex Regional Pain Syndrome (CRPS) Type 1 Completed NCT01960400
48 Audio-Visual Relaxation Technology for Pediatric Amplified Musculoskeletal Pain Syndrome: A Pilot Randomized Controlled Trial Completed NCT03762213
49 Effects of Pennsaid on Clinical Neuropathic Pain Completed NCT01508676 Pennsaid;Placebo (2.3% DMSO solution)
50 Near-infrared Spectroscopic Measurement of Tissue Oxygen Saturation and the Vascular Occlusion Test in Complex Regional Pain Syndrome Completed NCT01586377

Search NIH Clinical Center for Reflex Sympathetic Dystrophy

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ethanol

Cochrane evidence based reviews: reflex sympathetic dystrophy

Sources

Genetic Tests for Reflex Sympathetic Dystrophy

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Sources

Anatomical Context for Reflex Sympathetic Dystrophy

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Organs/tissues related to Reflex Sympathetic Dystrophy:

MalaCards : Dorsal Root Ganglion, Spinal Cord, Skin, Cortex, Bone, Brain, Bone Marrow
Sources

Publications for Reflex Sympathetic Dystrophy

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Articles related to Reflex Sympathetic Dystrophy:

(show top 50) (show all 2276)
# Title Authors PMID Year
1
HLA-DQ1 associated with reflex sympathetic dystrophy. 62 57
10522900 1999
2
Could calcitonin be a useful therapeutic agent for trigeminal neuralgia? 53 62
18343043 2008
3
[What is the place of diphosphonates in the treatment of complex regional pain syndrome I?]. 53 62
15833263 2005
4
Complex regional pain syndrome after thromboendarterectomy: which type is it? 53 62
12192276 2002
5
Calcitonin in reflex sympathetic dystrophy syndrome and other painful conditions. 53 62
12008165 2002
6
[Experiences with calcitonin treatment of patients with type I complex regional pain syndrome (CRPS I--Sudeck disease)]. 53 62
11605299 2001
7
Treatment of reflex sympathetic dystrophy (CRPS type 1): a research synthesis of 21 randomized clinical trials. 53 62
11397610 2001
8
[Calcitonin -- 1998]. 53 62
10101452 1998
9
Calcitonin treatment in reflex sympathetic dystrophy: a preliminary study. 53 62
9015909 1996
10
Plasma neuropeptide Y in the symptomatic limb of patients with causalgic pain. 53 62
7994163 1994
11
[Calcitonin as medication in pain?]. 53 62
8433948 1993
12
Influence of calcitonin treatment on the osteocalcin concentration in the algodystrophy of bone. 53 62
1281061 1992
13
The use of intranasal calcitonin in the treatment of algodystrophy. 53 62
1643458 1992
14
The effect of adding calcitonin to physical treatment on reflex sympathetic dystrophy. 53 62
1589234 1992
15
The use of nasal calcitonin in the treatment of post-traumatic algodystrophy. 53 62
1863827 1991
16
[Telethermography in the early diagnosis and clinico-therapeutic monitoring of Sudeck's disease]. 53 62
1718654 1991
17
[Calcitonin.]. 53 62
18415215 1990
18
[The calcitonin treatment of patients with algodystrophy]. 53 62
2080602 1990
19
How to Treat Algodystrophy and Rheumatic Comorbidity in Myelofibrosis: Three Case Reports. 62
36120194 2022
20
Effect of Perioperative Vitamin C on the Incidence of Complex Regional Pain Syndrome: A Systematic Review and Meta-Analysis. 62
34961681 2022
21
Discussion: Outcomes of Carpal Tunnel Release in Complex Regional Pain Syndrome/Reflex Sympathetic Dystrophy/Sudeck Disease Patients. 62
35767634 2022
22
Outcomes of Carpal Tunnel Release in Complex Regional Pain Syndrome/Reflex Sympathetic Dystrophy/Sudeck Disease Patients. 62
35536771 2022
23
Long-term biopsychosocial issues and health-related quality of life in young adolescents and adults treated for childhood Complex Regional Pain Syndrome, type 1. 62
35639860 2022
24
Functional Outcomes of Centralization of the Ulna as a Method of Reconstruction Following Resection of Campanacci Grade 3 Giant Cell Tumor of the Distal Radius. 62
35842330 2022
25
Partial Resection of First Dorsal Compartment Extensor Retinaculum in De Quervain's Stenosing Tendovaginitis Release. 62
35686888 2022
26
The Rationale for Using Neridronate in Musculoskeletal Disorders: From Metabolic Bone Diseases to Musculoskeletal Pain. 62
35805927 2022
27
Effectiveness of pulsed electromagnetic field therapy in the management of complex regional pain syndrome type 1: A randomized-controlled trial. 62
35949961 2022
28
Effectiveness of prednisolone in complex regional pain syndrome treatment: A systematic narrative review. 62
34779145 2022
29
Successful treatment of complex regional pain syndrome type 1 of upper limb with cryoneurolysis of the stellate ganglion: A rare case report. 62
34528377 2022
30
The quadriceps tendon autograft is an option for primary PCL reconstruction: a systematic review. 62
35543656 2022
31
Percutaneous Bunionette Correction: Retrospective Case Series. 62
32608244 2022
32
The Tourniquet Ischemia Test Effectively Predicts the Efficacy of Lumbar Sympathetic Block in Patients with Lower Extremity Complex Regional Pain Syndrome Type 1. 62
35698569 2022
33
Applications of thermal imaging with infrared thermography in Orthopaedics. 62
34926152 2022
34
Determinants of Diagnostic Delay in Complex Regional Pain Syndrome Type 1: An Observational Study of 180 Consecutive New Cases. 62
32897995 2021
35
Complex Regional Pain Syndrome in Athletes: Scoping Review. 62
34833480 2021
36
Complex Regional Pain Syndrome Type I Following Non-Orthopedic Surgery: Case Report and Narrative Review. 62
34573938 2021
37
Sensory Function and Psychological Factors in Children With Complex Regional Pain Syndrome Type 1. 62
33882728 2021
38
Direct Peripheral Nerve Stimulation for the Treatment of Complex Regional Pain Syndrome: A 30-Year Review. 62
33098229 2021
39
Direct Sciatic Nerve Electrical Stimulation for Complex Regional Pain Syndrome Type 1. 62
33171547 2021
40
Involvement of nuclear factor κB and descending pain pathways in the anti-hyperalgesic effect of β-citronellol, a food ingredient, complexed in β-cyclodextrin in a model of complex regional pain syndrome - Type 1. 62
34051299 2021
41
Is trigeminal neuralgia the only definitive diagnosis for pain in a tooth extraction site? 62
34098927 2021
42
Prospective randomized study of the vitamin C effect on pain and complex pain regional syndrome after total knee arthroplasty. 62
33438072 2021
43
Diagnosis of complex regional pain syndrome type 1 in patients with corticobasal degeneration: a case report. 62
32954740 2021
44
The long-term effect of complex regional pain syndrome type 1 on disability and quality of life after foot injury. 62
31411910 2021
45
Intramuscular neridronate for the treatment of complex regional pain syndrome type 1: a randomized, double-blind, placebo-controlled study. 62
34178124 2021
46
Amputation With Osseointegration for Patients With Intractable Complex Regional Pain Syndrome: A Report of 3 Cases. 62
33448707 2021
47
InSafeLOCK® humeral nailing for humeral nonunions: Clinical and radiological results. 62
34145823 2021
48
Extensor Retinaculum Flap and Fibular Periosteum Ligamentoplasty After Failed Surgery for Chronic Lateral Ankle Instability. 62
32755269 2020
49
Anesthetic Management of a Complex Regional Pain Syndrome (CRPS) Patient With Ketamine. 62
33393601 2020
50
Complex Regional Pain Syndrome Caused by an Axillary Lipoma. 62
33510987 2020
Sources

Variations for Reflex Sympathetic Dystrophy

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Expression for Reflex Sympathetic Dystrophy

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Search GEO for disease gene expression data for Reflex Sympathetic Dystrophy.
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Pathways for Reflex Sympathetic Dystrophy

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Pathways related to Reflex Sympathetic Dystrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 3
11.63 SCN9A SCN11A NPY NGF CALCA ADRB2
2
Phase 0 - rapid depolarisation 66
10.85 SCN9A SCN11A
3
Interaction between L1 and Ankyrins 66
10.75 SCN9A SCN11A
4
Endothelin pathways 74
10.65 NPY CALCA
5
Sympathetic Nerve Pathway (Neuroeffector Junction) 60
10.32 NPY ADRB2
Sources

GO Terms for Reflex Sympathetic Dystrophy

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Cellular components related to Reflex Sympathetic Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.63 TRPV1 SCN9A NPY GABRA3 CALCA
2 axon GO:0030424 9.61 TAC1 SCN9A SCN11A NGF CALCA
3 voltage-gated sodium channel complex GO:0001518 9.56 SCN9A SCN11A
4 neuronal dense core vesicle GO:0098992 8.92 NPY CALCA ADRB2

Biological processes related to Reflex Sympathetic Dystrophy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 10.03 TRPV1 TAC1 CD36 CALCA
2 monoatomic ion transmembrane transport GO:0034220 9.88 TRPV1 SCN9A SCN11A GABRA3
3 sensory perception of pain GO:0019233 9.85 TRPV1 TAC1 SCN9A
4 membrane depolarization during action potential GO:0086010 9.83 SCN9A SCN11A
5 diet induced thermogenesis GO:0002024 9.8 TRPV1 ADRB2
6 cellular response to nerve growth factor stimulus GO:1990090 9.8 TRPV1 TAC1 CALCA
7 negative regulation of smooth muscle contraction GO:0045986 9.71 ADRB2 CALCA
8 behavioral response to pain GO:0048266 9.69 TRPV1 SCN9A
9 response to pain GO:0048265 9.55 TRPV1 TAC1 CALCA
10 behavioral response to formalin induced pain GO:0061368 9.54 SCN9A SCN11A
11 response to heat GO:0009408 9.43 TRPV1 SCN9A SCN11A CALCA
12 calcitonin gene-related peptide receptor signaling pathway GO:1990408 9.26 SCN11A CALCA
13 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.1 TRPV1 SCN9A SCN11A CALCA

Molecular functions related to Reflex Sympathetic Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monoatomic cation channel activity GO:0005261 9.13 TRPV1 SCN9A SCN11A
2 monoatomic ion channel activity GO:0005216 9.02 TRPV1 SCN9A SCN11A GABRA3
Sources

Sources for Reflex Sympathetic Dystrophy

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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