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MCID: RFL001
MIFTS: 52

Reflex Sympathetic Dystrophy

Categories: Neuronal diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Reflex Sympathetic Dystrophy

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MalaCards integrated aliases for Reflex Sympathetic Dystrophy:

Name: Reflex Sympathetic Dystrophy 57 12 59 55 44 15 73
Reflex Sympathetic Dystrophy Syndrome 76 54
Algodystrophy 59 55
Complex Regional Pain Syndrome Type 1 59
Complex Regional Pain Syndromes 73
Complex Regional Pain Syndrome 59
Algodystrophic Syndrome 73

Characteristics:

Orphanet epidemiological data:

59
complex regional pain syndrome
Inheritance: Not applicable; Prevalence: 1-5/10000 (Netherlands); Age of onset: All ages; Age of death: normal life expectancy;
complex regional pain syndrome type 1
Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare neurological diseases


External Ids:

OMIM 57 604335
Disease Ontology 12 DOID:1811
ICD10 33 G90.5 M89.0
MeSH 44 D012019
NCIt 50 C85042
MESH via Orphanet 45 D020918
UMLS via Orphanet 74 C0458219 C1527353 C0034931
ICD10 via Orphanet 34 M89.0 G56.4
Sources

Summaries for Reflex Sympathetic Dystrophy

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NINDS : 54 Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

MalaCards based summary : Reflex Sympathetic Dystrophy, also known as reflex sympathetic dystrophy syndrome, is related to complex regional pain syndrome and causalgia, and has symptoms including seizures, tremor and back pain. An important gene associated with Reflex Sympathetic Dystrophy is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways/superpathways are Peptide ligand-binding receptors and G alpha (s) signalling events. The drugs Bupivacaine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and spinal cord, and related phenotypes are dry skin and erythema

Wikipedia : 76 Complex Regional Pain Syndrome (CRPS), also known as Reflex Sympathetic Dystrophy (RSD), is a disorder... more...

Description from OMIM: 604335
Sources

Related Diseases for Reflex Sympathetic Dystrophy

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Diseases related to Reflex Sympathetic Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 complex regional pain syndrome 33.5 CALCA NPY
2 causalgia 32.3 CALCA NPS NPY
3 anxiety 29.7 NPS NPY
4 migraine with or without aura 1 29.4 CALCA NPS
5 autonomic nervous system disease 29.2 CALCA CHSY1 NPS NPY
6 algoneurodystrophy 12.4
7 dysautonomia 11.6
8 thoracic outlet syndrome 11.4
9 neuropathy, hereditary sensory and autonomic, type iii 11.2
10 hemiplegia 10.4
11 dystonia 10.4
12 neuropathy 10.4
13 pain - chronic 10.3
14 arthritis 10.3
15 brittle bone disorder 10.2
16 psoriatic arthritis 10.2
17 osteomalacia 10.2
18 conversion disorder 10.2
19 herpes zoster 10.2
20 erythermalgia, primary 10.1
21 systemic lupus erythematosus 10.1
22 osteoporosis 10.1
23 burns 10.1
24 spinal cord injury 10.1
25 bone resorption disease 10.1
26 post-thrombotic syndrome 10.1
27 radiculopathy 10.1
28 myofascial pain syndrome 10.1
29 lupus erythematosus 10.1
30 erythromelalgia 10.1
31 fibromyalgia 10.1
32 headache 10.1
33 leprosy 2 10.1 CALCA NPY
34 osteoporosis, juvenile 10.1 CALCA CD36
35 epispadias 10.0 CALCA NPY
36 carcinoid syndrome 10.0 CALCA NPY
37 spinocerebellar degeneration 10.0 CD36 NPY
38 primary hyperparathyroidism 10.0 CALCA CD36
39 constipation 10.0 CALCA NPY
40 synovial chondromatosis 10.0
41 spondyloarthropathy 1 10.0
42 tetanus 10.0
43 movement disease 10.0
44 spondylitis 10.0
45 amyotrophic lateral sclerosis 1 10.0
46 carpal tunnel syndrome 10.0
47 cryoglobulinemia, familial mixed 10.0
48 renal cell carcinoma, nonpapillary 10.0
49 nail disorder, nonsyndromic congenital, 3 10.0
50 thrombophilia due to thrombin defect 10.0

Graphical network of the top 20 diseases related to Reflex Sympathetic Dystrophy:



Diseases related to Reflex Sympathetic Dystrophy
Sources

Symptoms & Phenotypes for Reflex Sympathetic Dystrophy

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Clinical features from OMIM:

604335

Human phenotypes related to Reflex Sympathetic Dystrophy:

59 (show all 12)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dry skin 59 Frequent (79-30%)
2 erythema 59 Frequent (79-30%)
3 involuntary movements 59 Frequent (79-30%)
4 edema of the lower limbs 59 Frequent (79-30%)
5 sensory impairment 59 Frequent (79-30%)
6 slow-growing nails 59 Frequent (79-30%)
7 allodynia 59 Frequent (79-30%)
8 limb pain 59 Very frequent (99-80%)
9 edema of the upper limbs 59 Frequent (79-30%)
10 trophic changes related to pain 59 Frequent (79-30%)
11 hyperalgesia 59 Frequent (79-30%)
12 abnormality of hair growth 59 Frequent (79-30%)

UMLS symptoms related to Reflex Sympathetic Dystrophy:


seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness, neuralgia
Sources

Drugs & Therapeutics for Reflex Sympathetic Dystrophy

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Drugs for Reflex Sympathetic Dystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 140)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
2
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 124-94-7 31307
3
Lidocaine Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 137-58-6 3676
4
Gabapentin Approved, Investigational Phase 4,Not Applicable 60142-96-3 3446
5
gamma-Aminobutyric acid Approved, Investigational Phase 4,Not Applicable 56-12-2 119
6
Salmon Calcitonin Approved, Investigational Phase 4 47931-85-1 16129616
7
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 50-81-7 5785 54670067
8
Calcitonin gene-related peptide Investigational Phase 4 83652-28-2
9 triamcinolone acetonide Phase 4,Phase 3,Not Applicable
10 Triamcinolone diacetate Phase 4,Phase 3,Not Applicable
11 Triamcinolone hexacetonide Phase 4,Phase 3,Not Applicable
12 Micronutrients Phase 4,Phase 3,Not Applicable
13 Antioxidants Phase 4,Phase 3,Not Applicable
14 Protective Agents Phase 4,Phase 3,Not Applicable
15 Vitamins Phase 4,Phase 3,Not Applicable
16 Trace Elements Phase 4,Phase 3,Not Applicable
17 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
19 Anesthetics, Local Phase 4,Phase 3,Not Applicable,Early Phase 1
20 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
21 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
22 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
23 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
24 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2
25 Diuretics, Potassium Sparing Phase 4,Early Phase 1,Not Applicable
26 GABA Agents Phase 4,Not Applicable
27 Excitatory Amino Acid Antagonists Phase 4,Phase 2,Not Applicable
28 Antiparkinson Agents Phase 4,Not Applicable
29 Excitatory Amino Acids Phase 4,Phase 2,Not Applicable
30 calcium channel blockers Phase 4,Phase 2,Not Applicable
31 Anticonvulsants Phase 4,Phase 2,Not Applicable
32 Anti-Arrhythmia Agents Phase 4,Phase 2,Early Phase 1,Not Applicable
33 Anti-Anxiety Agents Phase 4,Phase 2,Not Applicable
34 Antimanic Agents Phase 4,Not Applicable
35 Sodium Channel Blockers Phase 4,Early Phase 1,Not Applicable
36 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
37 Tranquilizing Agents Phase 4,Phase 2,Not Applicable
38 Vasodilator Agents Phase 4,Phase 2
39 calcitonin Phase 4
40
Ropivacaine Approved Phase 3,Not Applicable 84057-95-4 175805 71273
41
Levobupivacaine Approved, Investigational Phase 3,Not Applicable 27262-47-1 92253
42
Zoledronic acid Approved Phase 3,Phase 2 118072-93-8 68740
43
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3,Not Applicable 437-38-7 3345
44
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
45
Hydrocodone Approved, Illicit, Investigational Phase 3 125-29-1 5284569
46
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
47
Imidacloprid Vet_approved Phase 3 105827-78-9 86418
48 Pharmaceutical Solutions Phase 3,Not Applicable
49 gamma-Globulins Phase 3
50 Immunoglobulins, Intravenous Phase 3

Interventional clinical trials:

(show top 50) (show all 140)
# Name Status NCT ID Phase Drugs
1 Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome Recruiting NCT03291197 Phase 4 Suprascapular and median nerve blocks
2 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
3 Restore Claims Characterization Study Completed NCT00200122 Phase 4
4 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
5 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
6 (SGB) in Men Treated for Prostate Cancer Improve Hot Flashes Not yet recruiting NCT03796195 Phase 4 .5% Bupivacaine
7 Bupivacaine Versus Lidocaine Local Anesthesia Completed NCT01751347 Phase 4 Bupivacaine;Lidocaine
8 Efficacy and Safety of Salmon Calcitonin Nasal Spray in Improving Muscle Strength and Reducing Pain After Forearm Fracture in Postmenopausal Women Completed NCT00239889 Phase 4 Salmon calcitonin
9 Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease Enrolling by invitation NCT03406338 Phase 4 Collagenase Clostridium Histolyticum
10 Acupuncture for Post-stroke Shoulder-hand Syndrome Unknown status NCT02011854 Phase 2, Phase 3
11 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Unknown status NCT02390505 Phase 3 Vitamin C;Placebo
12 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
13 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
14 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
15 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
16 Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS) Recruiting NCT03560986 Phase 3 Neridronic acid;Placebo
17 Efficacy and Safety of Intravenous Neridronic Acid in CRPS-I Completed NCT02402530 Phase 2, Phase 3 Placebo;Neridronic acid 62.5 mg
18 Pain Exposure Physical Therapy (PEPT) Versus CBO in Patients With Complex Regional Pain Syndrome Type I (CRPS-1) Completed NCT00817128 Phase 2, Phase 3
19 A Study of the Effect of Lenalidamide on Complex Regional Pain Syndrome Type 1 Completed NCT00166452 Phase 3 Lenalidamide
20 Safety of Intravenous Neridronic Acid in CRPS Completed NCT02972359 Phase 3 Neridronic acid
21 A Confirmatory Study of Fentanyl in Participants With Post-herpetic Neuralgia, Complex Regional Pain Syndrome or Postoperative Pain Syndrome Completed NCT01008553 Phase 3 Fentanyl;Placebo
22 CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1 Active, not recruiting NCT02504008 Phase 3 AXS-02 (oral zoledronate);Placebo
23 Efficacy and Safety of Intravenous Neridronic Acid in CRPS Recruiting NCT03530345 Phase 3 Neridronic acid;Placebo
24 STRIPS: Shoulder Taping Reduces Injury and Pain in Stroke Completed NCT01062308 Phase 3
25 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
26 Study to Evaluate the Long-Term Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) in Patients Who Require Opioid Treatment for an Extended Period of Time Completed NCT01223365 Phase 3 Hydrocodone ER
27 Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain Completed NCT00343733 Phase 3 OraVescent Fentanyl
28 The Use of Zoledronic Acid to Complex Regional Pain Syndrome Unknown status NCT01788176 Phase 2 Zoledronic acid;Placebo
29 Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study) Unknown status NCT00377468 Phase 2 Delta9-Tetrahydrocannabinol
30 Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010) Unknown status NCT01184586 Phase 2
31 Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1 Terminated NCT00109772 Phase 2 lenalidomide;Placebo
32 Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome Terminated NCT02094352 Phase 2 Ketamine Infusion + Epidural Infusion;Control Group + Epidural infusion;Ketamine Booster Infusion;Control Group Booster Infusion
33 Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional Pain Syndrome (CRPS) Terminated NCT00689585 Phase 2 Placebo;Ethosuximide
34 A Study of CC-5013 in the Treatment of Complex Regional Pain Syndrome (CRPS) Completed NCT00067743 Phase 2 Lenalidomide
35 Adipose Stem/Stromal Cells in RSD, CRPS, Fibromyalgia Recruiting NCT02987855 Phase 1, Phase 2
36 Prospective, Randomized Controlled Trial on Perioperative Pregabalin to Reduce Late-onset CRPS After TKA Completed NCT00558753 Phase 2 pregabalin;Placebo
37 Neurotropin to Treat Chronic Neuropathic Pain Terminated NCT00006289 Phase 2 Placebo;Neurotropin
38 Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS Completed NCT00579085 Phase 2 Ketamine
39 Novel Treatment Option for Neuropathic Pain Completed NCT02490436 Phase 2 Cetuximab;Placebo
40 Study of HC-58 in Upper Limb Hemiplegic Patients After Stroke Completed NCT01623622 Phase 2 HC-58;Placebo
41 A Pilot Trial of IV Pamidronate for Low Back Pain Completed NCT01210599 Phase 1, Phase 2 Pamidronate
42 Effects of Vaporized Marijuana on Neuropathic Pain Completed NCT01037088 Phase 1, Phase 2 Mild dose cannabis;Low dose cannabis;Cannabis
43 Single-portal Endoscopic Carpal Tunnel Release Versus Knifelight for Carpal Tunnel Syndrome. A Randomized Control Trial Withdrawn NCT01756820 Phase 2
44 Clonidine Versus Adenosine to Treat Neuropathic Pain Completed NCT00349921 Phase 2 clonidine;adenosine;placebo;placebo
45 Efficacy of Etoricoxib on Peripheral Hyperalgesia Terminated NCT01088256 Phase 2 Etoricoxib;placebo
46 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
47 Two Measures of Tactile Acuity in CRPS Type I Patients Unknown status NCT01888783 Not Applicable
48 Effects of Repetitive Electric Sensory Stimulation (RSS) as Intervention in Complex-regional-pain-syndrome Type I (CRPS) Unknown status NCT01915329 Not Applicable
49 The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture Unknown status NCT01338129 Not Applicable placebo
50 Use of Compression Glove to Prevent Complications After Distal Radius Fractures: a Randomized Controlled Trial Unknown status NCT01118715 Not Applicable

Search NIH Clinical Center for Reflex Sympathetic Dystrophy

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: reflex sympathetic dystrophy

Sources

Genetic Tests for Reflex Sympathetic Dystrophy

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Sources

Anatomical Context for Reflex Sympathetic Dystrophy

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MalaCards organs/tissues related to Reflex Sympathetic Dystrophy:

41
Skin, Bone, Spinal Cord, Testes, Lung, Brain, Prostate
Sources

Publications for Reflex Sympathetic Dystrophy

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Articles related to Reflex Sympathetic Dystrophy:

(show top 50) (show all 823)
# Title Authors Year
1
How a Simple Ankle Sprain Turned Into Neuropathic Pain: Complex Reflex Sympathetic Dystrophy Versus Erythromelalgia. ( 29121832 )
2017
2
Pain, Complex Regional Pain Syndrome (Reflex Sympathetic Dystrophy, RSD, CRPS) ( 28613470 )
2017
3
Bone SPECT/CT Localizes Increased Bone Metabolism and Subsequent Bone Resorption in Reflex Sympathetic Dystrophy. ( 28806248 )
2017
4
The Relation Between Reflex Sympathetic Dystrophy Syndrome and Trauma Severity in Patients With Distal Tibia Fracture. ( 27626009 )
2016
5
Re: del Pinal F. Editorial: I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome - CRPS I) does not exist. J Hand Surg Eur. 2013, 38: 595-7. ( 24566455 )
2014
6
Re: del Pinal F. Editorial: I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome - CRPS I) does not exist. J Hand Surg Eur. 2013, 38: 595-7. ( 24448795 )
2014
7
Reflex sympathetic dystrophy-like syndrome, possibly caused by aripiprazole, in an adolescent patient. ( 25020186 )
2014
8
Sympathomimetic amine therapy found effective for treatment of refractory chronic complex regional pain syndrome (reflex sympathetic dystrophy). ( 25134306 )
2014
9
Reply: F del Piñal. Editorial: I have a dream … reflex sympathetic dystrophy (RSD or complex regional pain syndrome - CRPS I) does not exist. J Hand Surg Eur. 38: 595-7. ( 24596947 )
2014
10
Re: del PiA+al F. Editorial: I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome--CRPS 1) does not exist. J Hand Surg Eur. 2013, 38: 595-7. ( 24158709 )
2013
11
Editorial. I have a dream ... reflex sympathetic dystrophy (RSD or Complex Regional Pain Syndrome - CRPS I) does not exist. ( 23778064 )
2013
12
A case of linear morphoea mistaken for reflex sympathetic dystrophy. ( 23546034 )
2013
13
Unilateral Beau's lines in a case of complex regional pain syndrome (reflex sympathetic dystrophy). ( 23075662 )
2012
14
Reflex sympathetic dystrophy syndrome in a child. ( 21993705 )
2011
15
My sister fell and injured her shoulder a few months ago. She's developed terrible burning pain down into her arm. Her doctor says she has complex regional pain syndrome, also known as reflex sympathetic dystrophy. What is it? How is it treated? ( 21344692 )
2011
16
Reflex sympathetic dystrophy following pacemaker insertion. ( 22334977 )
2011
17
Tenosynovitis caused by a pseudallescheria boydii infection and symptoms of reflex sympathetic dystrophy after a dog bite. ( 21946460 )
2011
18
Lawsuit verdicts and settlements involving reflex sympathetic dystrophy and complex regional pain syndrome. ( 22214139 )
2011
19
Induction of prolonged mania during ketamine therapy for reflex sympathetic dystrophy. ( 21529780 )
2011
20
Is this complex regional pain syndrome or reflex sympathetic dystrophy? ( 21632229 )
2011
21
Reply: Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy? ( 20583223 )
2010
22
Complex regional pain syndrome/reflex sympathetic dystrophy. ( 20504141 )
2010
23
A hypothesis for the cause of complex regional pain syndrome-type I (reflex sympathetic dystrophy): pain due to deep-tissue microvascular pathology. ( 20704671 )
2010
24
A severe case of complex regional pain syndrome I (reflex sympathetic dystrophy) managed with spinal cord stimulation. ( 19863748 )
2010
25
Reflex sympathetic dystrophy in patients with metastatic renal cell carcinoma treated with everolimus. ( 19649567 )
2010
26
Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy? ( 19557864 )
2009
27
The efficacy of manual lymphatic drainage therapy in the management of limb edema secondary to reflex sympathetic dystrophy. ( 19030864 )
2009
28
Reflex sympathetic dystrophy secondary to deep venous thrombosis mimicking post-thrombotic syndrome. ( 19363611 )
2009
29
Reflex sympathetic dystrophy: complex regional pain syndrome type I in children with mitochondrial disease and maternal inheritance. ( 18192313 )
2008
30
Factitious lymphoedema as a psychiatric condition mimicking reflex sympathetic dystrophy: a case report. ( 18577230 )
2008
31
Reflex sympathetic dystrophy/complex regional pain syndrome. ( 18306652 )
2008
32
Unilateral trachyonychia in a patient with reflex sympathetic dystrophy. ( 18222330 )
2008
33
Complex regional pain syndrome (reflex sympathetic dystrophy) in a patient with essential mixed cryoglobulinemia and chronic hepatitis C. ( 17370795 )
2007
34
The effect of gabapentin in earlier stage of reflex sympathetic dystrophy. ( 16897121 )
2007
35
Unusual cases of acquired leukonychia totalis and partialis secondary to reflex sympathetic dystrophy. ( 17958875 )
2007
36
Complex regional pain syndrome I (reflex sympathetic dystrophy) associated with a superficial hand burn from a fan heater. ( 17535413 )
2007
37
Reflex sympathetic dystrophy: a case of total body pain. ( 17721352 )
2007
38
Reflex sympathetic dystrophy: a retrospective epidemiological study of 168 patients. ( 17221145 )
2007
39
Effects of weather changes on a patient with reflex sympathetic dystrophy. ( 17387368 )
2007
40
Reflex sympathetic dystrophy: reflections from a clinician. ( 18605399 )
2007
41
Reflex sympathetic dystrophy in a renal transplant patient treated with sirolimus. ( 17575313 )
2007
42
The role of the pain psychologist, trigger point injections, reflex sympathetic dystrophy. ( 17182517 )
2006
43
Spinal cord stimulation for chronic reflex sympathetic dystrophy--five-year follow-up. ( 16738284 )
2006
44
Current management of reflex sympathetic dystrophy syndrome (complex regional pain syndrome type I). ( 16837228 )
2006
45
Impact of three-phase bone scintigraphy on the diagnosis and treatment of complex regional pain syndrome type I or reflex sympathetic dystrophy. ( 16340227 )
2006
46
Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy). ( 16427737 )
2006
47
Determination of inflammation of reflex sympathetic dystrophy at early stages with Tc-99m HIG scintigraphy: preliminary results. ( 16025330 )
2006
48
Psychiatric approach in the treatment of reflex sympathetic dystrophy in an adolescent girl: a case report. ( 17290576 )
2006
49
Reflex sympathetic dystrophy in hemiplegia. ( 17106342 )
2006
50
Sympathetic skin responses in reflex sympathetic dystrophy. ( 16328419 )
2006
Sources

Variations for Reflex Sympathetic Dystrophy

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Expression for Reflex Sympathetic Dystrophy

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Search GEO for disease gene expression data for Reflex Sympathetic Dystrophy.
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Pathways for Reflex Sympathetic Dystrophy

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Pathways related to Reflex Sympathetic Dystrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Peptide ligand-binding receptors 66
Show member pathways
 12.72 CALCA GABRA3 NPS NPY
2
G alpha (s) signalling events 66
11.42 CALCA NPS
3
Adipocytokine signaling pathway 37
10.79 CD36 NPY
4
Endothelin Pathways 1
10.15 CALCA NPY
Sources

GO Terms for Reflex Sympathetic Dystrophy

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Biological processes related to Reflex Sympathetic Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.37 CALCA CD36
2 regulation of blood pressure GO:0008217 9.32 CALCA NPY
3 receptor internalization GO:0031623 9.26 CALCA CD36
4 feeding behavior GO:0007631 9.16 CALCA NPY
5 negative regulation of ossification GO:0030279 8.96 CALCA CHSY1
6 neuropeptide signaling pathway GO:0007218 8.8 CALCA NPS NPY

Molecular functions related to Reflex Sympathetic Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 CALCA NPY
Sources

Sources for Reflex Sympathetic Dystrophy

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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