MCID: RGL001
MIFTS: 27

Regular Astigmatism

Categories: Eye diseases

Aliases & Classifications for Regular Astigmatism

MalaCards integrated aliases for Regular Astigmatism:

Name: Regular Astigmatism 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11781
ICD10 33 H52.22
ICD9CM 35 367.21
SNOMED-CT 68 68905002
UMLS 73 C0152193

Summaries for Regular Astigmatism

MalaCards based summary : Regular Astigmatism is related to astigmatism and aortic aneurysm, familial thoracic 2. An important gene associated with Regular Astigmatism is INSRR (Insulin Receptor Related Receptor), and among its related pathways/superpathways is Tyrosine Kinases / Adaptors. Affiliated tissues include eye and endothelial, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Regular Astigmatism

Diseases related to Regular Astigmatism via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 astigmatism 30.5 CER1 DPT NBL1
2 aortic aneurysm, familial thoracic 2 10.3 FLNA SLC2A10
3 preretinal fibrosis 10.1 DPT LCK
4 cataract 9.9
5 keratoconus 9.9
6 refractive error 9.9
7 endotheliitis 9.9
8 ametropic amblyopia 9.6 CYLC1 DPT

Graphical network of the top 20 diseases related to Regular Astigmatism:



Diseases related to Regular Astigmatism

Symptoms & Phenotypes for Regular Astigmatism

GenomeRNAi Phenotypes related to Regular Astigmatism according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.53 CYLD INSRR LCK MATK
2 Decreased viability GR00221-A-2 9.53 CYLD LCK
3 Decreased viability GR00221-A-3 9.53 LCK
4 Decreased viability GR00301-A 9.53 CYLD INSRR LCK
5 Decreased viability GR00342-S-1 9.53 LCK
6 Decreased viability GR00342-S-3 9.53 LCK
7 Decreased viability GR00402-S-2 9.53 CYLD INSRR LCK MATK
8 Decreased substrate adherent cell growth GR00193-A-1 9.5 MATK
9 Decreased substrate adherent cell growth GR00193-A-2 9.5 JAK2 LCK MATK
10 Decreased substrate adherent cell growth GR00193-A-3 9.5 JAK2 LCK
11 Decreased substrate adherent cell growth GR00193-A-4 9.5 LCK

MGI Mouse Phenotypes related to Regular Astigmatism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.65 ASPH CER1 CYLD DPT FLNA JAK2
2 normal MP:0002873 9.28 CER1 CYLD FLNA INSRR JAK2 MATK

Drugs & Therapeutics for Regular Astigmatism

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Measurement Repeatability in Contemporary Aberrometry Unknown status NCT02687022 Not Applicable
2 Study of Clinical Performance of Corneal Topography Measurement Using an Optical Biometer Completed NCT01861925
3 Observational Study of Keratoconus and Post-keratoplasty Eyes Completed NCT02109848
4 Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste Keratoconus Completed NCT02617368
5 Manually Performed Limbal Relaxing Incisions vs Femtosecond Laser-guided Astigmatic Keratotomy Not yet recruiting NCT03264534 Not Applicable

Search NIH Clinical Center for Regular Astigmatism

Genetic Tests for Regular Astigmatism

Anatomical Context for Regular Astigmatism

MalaCards organs/tissues related to Regular Astigmatism:

41
Eye, Endothelial

Publications for Regular Astigmatism

Articles related to Regular Astigmatism:

# Title Authors Year
1
Clinical Performance of a Spherical Hybrid Lens Design in High Regular Astigmatism. ( 27660920 )
2016
2
Evaluation of the orientation of the steepest meridian of regular astigmatism among highly myopic Egyptian patients seeking non-ablative surgical correction of the refractive error. ( 26435831 )
2015
3
Comparison of two different scheimpflug devices in the detection of keratoconus, regular astigmatism, and healthy corneas. ( 25954510 )
2015
4
Combined special capsular tension ring and toric IOL implantation for management of post-DALK high regular astigmatism with subluxated traumatic cataract. ( 25116780 )
2014
5
Combined Descemet-stripping automated endothelial keratoplasty and phacoemulsification with toric intraocular lens implantation for treatment of failed penetrating keratoplasty with high regular astigmatism. ( 22296843 )
2012
6
Bivariate analysis of surgically induced regular astigmatism. Mathematical analysis and graphical display. ( 10615439 )
1999

Variations for Regular Astigmatism

Expression for Regular Astigmatism

Search GEO for disease gene expression data for Regular Astigmatism.

Pathways for Regular Astigmatism

Pathways related to Regular Astigmatism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.97 JAK2 LCK MATK

GO Terms for Regular Astigmatism

Cellular components related to Regular Astigmatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extrinsic component of cytoplasmic side of plasma membrane GO:0031234 8.92 CYLD JAK2 LCK MATK

Biological processes related to Regular Astigmatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.91 CYLC1 INSRR JAK2 LCK MATK ZEB1
2 negative regulation of cell proliferation GO:0008285 9.8 ASPH CER1 DPT JAK2 ZEB1
3 negative regulation of BMP signaling pathway GO:0030514 9.5 CER1 NBL1 SOST
4 mesoderm development GO:0007498 9.48 JAK2 MATK
5 positive regulation of T cell receptor signaling pathway GO:0050862 9.46 CYLD LCK
6 peptidyl-tyrosine phosphorylation GO:0018108 9.46 INSRR JAK2 LCK MATK
7 peptidyl-tyrosine autophosphorylation GO:0038083 9.43 JAK2 LCK MATK
8 determination of dorsal identity GO:0048263 9.37 CER1 NBL1
9 sequestering of BMP in extracellular matrix GO:0035582 8.96 CER1 NBL1
10 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 8.92 INSRR JAK2 LCK MATK

Molecular functions related to Regular Astigmatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SH2 domain binding GO:0042169 9.4 JAK2 LCK
2 insulin receptor substrate binding GO:0043560 9.37 INSRR JAK2
3 non-membrane spanning protein tyrosine kinase activity GO:0004715 9.33 JAK2 LCK MATK
4 BMP binding GO:0036122 9.32 CER1 NBL1
5 morphogen activity GO:0016015 9.26 CER1 NBL1
6 protein tyrosine kinase activity GO:0004713 9.26 INSRR JAK2 LCK MATK
7 phosphatidylinositol 3-kinase binding GO:0043548 8.8 INSRR JAK2 LCK

Sources for Regular Astigmatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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