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MCID: RLP003
MIFTS: 44

Relapsing Fever

Categories: Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Relapsing Fever

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MalaCards integrated aliases for Relapsing Fever:

Name: Relapsing Fever 12 59 55 44 15 73

Characteristics:

Orphanet epidemiological data:

59
relapsing fever
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:13034
ICD10 33 A68 A68.9
ICD9CM 35 087 087.9
MeSH 44 D012061
Orphanet 59 ORPHA91547
MESH via Orphanet 45 D012061
UMLS via Orphanet 74 C0035021
ICD10 via Orphanet 34 A68.0 A68.1 A68.9
UMLS 73 C0035021
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Summaries for Relapsing Fever

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Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Borrelia, which is transmitted by tick or transmitted by body louse.

MalaCards based summary : Relapsing Fever is related to tick-borne relapsing fever and louse-borne relapsing fever, and has symptoms including recurrent fevers An important gene associated with Relapsing Fever is MVK (Mevalonate Kinase), and among its related pathways/superpathways are Transcription_NF-kB signaling pathway and Photodynamic therapy-induced AP-1 survival signaling.. The drugs Anti-Bacterial Agents and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spleen.

Wikipedia : 76 Relapsing fever is a vector-borne disease caused by infection with certain bacteria in the genus... more...

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Related Diseases for Relapsing Fever

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Diseases related to Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 tick-borne relapsing fever 33.8 AKAP13 CLPX
2 louse-borne relapsing fever 33.8 ARSI CRP TNF
3 lyme disease 30.8 CFH CRP TNF
4 leptospirosis 30.2 CRP TNF
5 peritonitis 29.6 CRP MEFV TNF
6 vasculitis 29.4 CRP MEFV TNF
7 epidemic typhus 11.4
8 trench fever 11.2
9 pediculus humanus corporis infestation 11.2
10 sodoku disease 10.8
11 tick infestation 10.8
12 multifocal choroiditis 10.7 CFH TNF
13 choroiditis 10.7 CFH TNF
14 haemophilus influenzae 10.7 CFH TNF
15 posterior uveitis 10.7 CFH TNF
16 melancholia 10.6 CRP TNF
17 central nervous system vasculitis 10.6 CRP TNF
18 diverticulitis 10.6 CRP TNF
19 tuberculous peritonitis 10.6 CRP TNF
20 ischemic heart disease 10.6 CRP TNF
21 cellulitis 10.6 CRP TNF
22 streptococcal meningitis 10.6 CRP TNF
23 scrub typhus 10.6 CRP TNF
24 systolic heart failure 10.6 CRP TNF
25 chronic gonococcal salpingitis 10.5 TNF TNFRSF1A
26 retinitis pigmentosa 75 10.5 TNF TNFRSF1A
27 pleural disease 10.5 CRP TNF
28 proctitis 10.5 CRP TNF
29 apnea, obstructive sleep 10.5 CRP TNF
30 dystrophinopathies 10.5 TNF TNFRSF1A
31 perinatal necrotizing enterocolitis 10.5 CRP TNF
32 infective endocarditis 10.5 CRP TNF
33 pericoronitis 10.5 CRP TNFRSF1A
34 hemorrhagic fever with renal syndrome 10.5 CRP TNF
35 acute salpingitis 10.5 TNF TNFRSF1A
36 suppurative cholangitis 10.5 CRP TNF
37 post-transplant lymphoproliferative disease 10.5 TNF TNFRSF1A
38 systemic onset juvenile idiopathic arthritis 10.5 MEFV TNF
39 autoinflammation, panniculitis, and dermatosis syndrome 10.5 MEFV TNF
40 lymph node disease 10.5 CRP TNF
41 chronic salpingitis 10.5 TNF TNFRSF1A
42 exanthem 10.5 CRP TNF
43 uterine anomalies 10.5 CRP TNF
44 erysipelas 10.4 MEFV TNF
45 pancreas disease 10.4 CRP TNF
46 hypersensitivity vasculitis 10.4 CRP MEFV
47 reactive arthritis 10.4 CRP TNF
48 amyloidosis aa 10.4 CRP MEFV
49 hypersensitivity reaction type iii disease 10.4 CRP MEFV
50 cervical adenitis 10.4 MEFV MVK

Graphical network of the top 20 diseases related to Relapsing Fever:



Diseases related to Relapsing Fever
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Symptoms & Phenotypes for Relapsing Fever

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UMLS symptoms related to Relapsing Fever:


recurrent fevers
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Drugs & Therapeutics for Relapsing Fever

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Drugs for Relapsing Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
2 Antibiotics, Antitubercular Phase 4
3 Anti-Infective Agents Phase 4,Phase 2,Phase 3
4
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
5 Antimalarials Phase 2, Phase 3
6 Antiparasitic Agents Phase 2, Phase 3
7 Antiprotozoal Agents Phase 2, Phase 3
8
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
9
Caspofungin Approved Phase 2 179463-17-3, 162808-62-0 468682 2826718
10
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
11 Antifungal Agents Phase 2
12 Echinocandins Phase 2
13 Liposomal amphotericin B Phase 2
14 Antibodies Not Applicable
15 Immunoglobulins Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia Completed NCT01581333 Phase 4 Empirical antimicrobial treatment discontinuation;Standard empirical antimicrobial treatment discontinuation
2 Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever Completed NCT00237016 Phase 2, Phase 3 doxycycline treatment
3 A Study of Caspofungin, Liposomal Amphotericin B or the Combination of Both for Patients After Stem-Cell Transplantation Completed NCT00148148 Phase 2 caspofungin;liposomal amphotericin B
4 Perifosine in Patients With Relapsed/Refractory Waldenstrom's Macroglobulinemia Completed NCT00422656 Phase 2 Perifosine
5 Tocilizumab in Patients With Schnitzler's Syndrome Recruiting NCT03046381 Phase 2 Tocilizumab
6 Life Quality Study for PFAPA Patient Unknown status NCT02811705
7 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
8 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830 Not Applicable
9 Exercise Capacity and Physical Activity Levels in Newly Diagnosed Hematologic Malignant Patients Recruiting NCT03212560

Search NIH Clinical Center for Relapsing Fever

Cochrane evidence based reviews: relapsing fever

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Genetic Tests for Relapsing Fever

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Anatomical Context for Relapsing Fever

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MalaCards organs/tissues related to Relapsing Fever:

41
Brain, Testes, Spleen, Neutrophil, Heart, Salivary Gland, B Cells
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Publications for Relapsing Fever

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Articles related to Relapsing Fever:

(show top 50) (show all 565)
# Title Authors Year
1
Colony formation in solid medium by the relapsing fever spirochetes Borrelia hermsii and Borrelia turicatae. ( 29169853 )
2018
2
Tick-Borne Relapsing Fever with Severe Jarisch-Herxheimer Reaction. ( 29658212 )
2018
3
Tick-Borne Relapsing Fever with Severe Jarisch-Herxheimer Reaction. ( 29333799 )
2018
4
Isolation and molecular characterization of a relapsing fever Borrelia recovered from Ornithodoros rudis in Brazil. ( 29571703 )
2018
5
Outbreak of Louse-Borne Relapsing Fever among Urban Dwellers in Arsi Zone, Central Ethiopia, from July to November 2016. ( 29692298 )
2018
6
Tick-borne relapsing fever as a potential veterinary medical problem. ( 29943903 )
2018
7
In Vitro Susceptibility of the Relapsing-Fever Spirochete Borrelia miyamotoi to Antimicrobial Agents. ( 28674060 )
2017
8
Ecological niche modeling and distribution of Ornithodoros hermsi associated with tick-borne relapsing fever in western North America. ( 29084219 )
2017
9
Relapsing fever causative agent in Southern Iran is a closely related species to East African borreliae. ( 28736193 )
2017
10
There Is a Method to the Madness: Strategies to Study Host Complement Evasion by Lyme Disease and Relapsing Fever Spirochetes. ( 28303129 )
2017
11
Division of the genus Borrelia into two genera (corresponding to Lyme disease and relapsing fever groups) reflects their genetic and phenotypic distinctiveness and will lead to a better understanding of these two groups of microbes (Margos et al. (2016) There is inadequate evidence to support the division of the genus Borrelia. Int. J. Syst. Evol. Microbiol. doi: 10.1099/ijsem.0.001717). ( 28141502 )
2017
12
Serological detection of Tick-Borne Relapsing Fever in Texan domestic dogs. ( 29232415 )
2017
13
Diagnosis of Louse-Borne Relapsing Fever despite Negative Microscopy in Two Asylum Seekers from Eastern Africa. ( 29016302 )
2017
14
Development and optimization of an inA vitro cultivation protocol allows for isolation of Borrelia miyamotoi from patients with hard tick-borne relapsing fever. ( 28110053 )
2017
15
Host Immune Evasion by Lyme and Relapsing Fever Borreliae: Findings to Lead Future Studies for Borrelia miyamotoi. ( 28154563 )
2017
16
Louse-borne relapsing fever in Finland in two asylum seekers from Somalia. ( 27859692 )
2017
17
A relapsing fever group Borrelia sp. is widely distributed among wild deer in Japan. ( 29329785 )
2017
18
Epidemiological study of relapsing fever borreliae detected in Haemaphysalis ticks and wild animals in the western part of Japan. ( 28362864 )
2017
19
Crystal Structure of Borrelia turicatae protein, BTA121, a differentially regulated A gene in the tick-mammalian transmission cycle of relapsing fever spirochetes. ( 29127407 )
2017
20
Relapsing fever in young refugees from East Africa. ( 28774320 )
2017
21
Plasmodium falciparum malaria co-infection with tick-borne relapsing fever in Dakar. ( 28077149 )
2017
22
Relapsing Fever ( 28722942 )
2017
23
Identification and characterization of a histamine-binding lipocalin-like molecule from the relapsing fever tick Ornithodoros turicata. ( 29164729 )
2017
24
Louse-borne relapsing fever in a refugee from Mali. ( 28161771 )
2017
25
Detection of relapsing fever Borrelia spp., Bartonella spp. and Anaplasmataceae bacteria in argasid ticks in Algeria. ( 29145396 )
2017
26
Transmission of Borrelia miyamotoi sensu lato relapsing fever group spirochetes in relation to duration of attachment by Ixodes scapularis nymphs. ( 28501504 )
2017
27
Louse-Borne Relapsing Fever (Borrelia recurrentis) in a Somali Refugee Arriving in Italy: A Re-emerging Infection in Europe? ( 27149282 )
2016
28
Regarding Tick-Borne Relapsing Fever in the Americas; Some Historical Aspects of a Forgotten Disease in Colombia. ( 29056741 )
2016
29
Molecular identification of Borrelia genus in questing hard ticks from Portugal: Phylogenetic characterization of two novel Relapsing Fever-like Borrelia sp. ( 26976475 )
2016
30
Louseborne Relapsing Fever among East African Refugees, Italy, 2015. ( 26812354 )
2016
31
Detection and Characterization of the Emerging Relapsing Fever Pathogen, Borrelia miyamotoi, from the Ixodes ricinus Tick in the Rural Trakya (Thrace) Region of Northwestern Turkey. ( 27788060 )
2016
32
Tick-Borne Relapsing Fever in Dogs. ( 27353196 )
2016
33
Where Are the Ticks? Solving the Mystery of a Tickborne Relapsing Fever Outbreak at a Youth Camp. ( 27188066 )
2016
34
Tick-Borne Relapsing Fever, Southern Spain, 2004-2015. ( 27442975 )
2016
35
Relapsing fever in asylum seekers from Somalia arriving in Belgium in August 2015. ( 27112219 )
2016
36
Correction: Expression of the Tick-Associated Vtp Protein of Borrelia hermsii in a Murine Model of Relapsing Fever. ( 27074024 )
2016
37
Tick-Borne Relapsing Fever Spirochetes in the Americas. ( 28959690 )
2016
38
An Alternative Strategy of Preventive Control of Tick-Borne Relapsing Fever in Rural Areas of Sine-Saloum, Senegal. ( 27430543 )
2016
39
Cyclic-di-GMP binding induces structural rearrangements in the PlzA and PlzC proteins of the Lyme disease and relapsing fever spirochetes: a possible switch mechanism for c-di-GMP-mediated effector functions. ( 27852620 )
2016
40
Tick-Borne Relapsing Fever Outbreak Among a High School Football Team at an Outdoor Education Camping Trip, Arizona, 2014. ( 27430539 )
2016
41
Borrelia miyamotoi: A human tick-borne relapsing fever spirochete in Europe and its potential impact on public health. ( 27100337 )
2016
42
Head Lice of Pygmies Reveal the Presence of Relapsing Fever Borreliae in the Republic of Congo. ( 27911894 )
2016
43
Louse-borne relapsing fever among East African refugees in Europe. ( 26872415 )
2016
44
Tick-Borne Relapsing Fever in Southwest Colorado: A Case Report. ( 27650717 )
2016
45
Borrelia sp. phylogenetically different from Lyme disease- and relapsing fever-related Borrelia spp. in Amblyomma varanense from Python reticulatus. ( 27342652 )
2016
46
Louseborne Relapsing Fever in Young Migrants, Sicily, Italy, July-September 2015. ( 26690334 )
2016
47
Epidemiological Study of Endemic Relapsing Fever in Hamadan Province, West of Iran. ( 28032111 )
2016
48
Fourth case of louse-borne relapsing fever in Young Migrant, Sicily, Italy, December 2015. Mini Review Article. ( 27340042 )
2016
49
Louse-borne relapsing fever - report of four cases in Switzerland, June-December 2015. ( 27188655 )
2016
50
Host associations and genomic diversity of Borrelia hermsii in an endemic focus of tick-borne relapsing fever in western North America. ( 27832805 )
2016
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Variations for Relapsing Fever

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Expression for Relapsing Fever

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Search GEO for disease gene expression data for Relapsing Fever.
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Pathways for Relapsing Fever

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Pathways related to Relapsing Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Transcription_NF-kB signaling pathway 22
11.19 TNF TNFRSF1A
2
Photodynamic therapy-induced AP-1 survival signaling. 1
11.14 TNF TNFRSF1A
3
Cellular Transformation by HTLV1 64
Show member pathways
 11.1 TNF TNFRSF1A
4
Interleukin-10 signaling 66
11.06 TNF TNFRSF1A
5
Ceramide signaling pathway 1
10.97 TNF TNFRSF1A
6
Signal transduction_JNK pathway 22
10.9 TNF TNFRSF1A
7
14-3-3 and Regulation of BAD Activity 64
10.66 TNF TNFRSF1A
8
Canonical NF-kappaB pathway 1
10.32 TNF TNFRSF1A
9
Overview of nanoparticle effects 1
9.9 CRP TNF
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GO Terms for Relapsing Fever

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Biological processes related to Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 CRP MEFV TNF TNFRSF1A
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.58 AKAP13 TNF TNFRSF1A
3 negative regulation of inflammatory response GO:0050728 9.5 MEFV MVK TNFRSF1A
4 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.48 TNF TNFRSF1A
5 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.46 TNF TNFRSF1A
6 regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 9.43 TNF TNFRSF1A
7 negative regulation of lipid storage GO:0010888 9.26 CRP TNF
8 positive regulation of ceramide biosynthetic process GO:2000304 9.16 TNF TNFRSF1A
9 death-inducing signaling complex assembly GO:0071550 8.96 TNF TNFRSF1A
10 regulation of establishment of endothelial barrier GO:1903140 8.62 TNF TNFRSF1A

Molecular functions related to Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 CRP MEFV MVK TNF TNFRSF1A
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Sources for Relapsing Fever

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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