Relapsing Fever disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: RLP003 MIFTS: 42	Relapsing Fever Categories: Infectious diseases, Rare diseases
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Aliases & Classifications for Relapsing Fever

MalaCards integrated aliases for Relapsing Fever:

Name: Relapsing Fever ¹² ⁵⁹ ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Characteristics:

Orphanet epidemiological data:

⁵⁹

relapsing fever
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases

See all MalaCards categories (disease lists)

ICD10: ³³ ³⁴

Certain infectious and parasitic diseases

Other spirochaetal diseases

Relapsing fevers

Louse-borne relapsing fever

Relapsing fever, unspecified

Tick-borne relapsing fever

Orphanet: ⁵⁹

Rare infectious diseases

External Ids:

Disease Ontology ¹² DOID:13034

ICD10 ³³ A68 A68.9

ICD9CM ³⁵ 087 087.9

MeSH ⁴⁴ D012061

SNOMED-CT ⁶⁸ 46107006

Orphanet ⁵⁹ ORPHA91547

MESH via Orphanet ⁴⁵ D012061

UMLS via Orphanet ⁷⁴ C0035021

ICD10 via Orphanet ³⁴ A68.0 A68.1 A68.9

UMLS ⁷³ C0035021

Sources

Summaries for Relapsing Fever

Disease Ontology : ¹² A primary bacterial infectious disease that results in infection, has material basis in Borrelia, which is transmitted by tick or transmitted by body louse.

MalaCards based summary : Relapsing Fever is related to tick-borne relapsing fever and louse-borne relapsing fever, and has symptoms including recurrent fevers An important gene associated with Relapsing Fever is MVK (Mevalonate Kinase), and among its related pathways/superpathways are Transcription_NF-kB signaling pathway and Photodynamic therapy-induced AP-1 survival signaling.. The drugs Antibiotics, Antitubercular and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart.

Wikipedia : ⁷⁶ Relapsing fever is a vector-born disease caused by infection with certain bacteria in the genus... more...

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Related Diseases for Relapsing Fever

Diseases related to Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)

#	Related Disease	Score	Top Affiliating Genes
1	tick-borne relapsing fever	34.1	CLPX PURA
2	louse-borne relapsing fever	34.1	ARSI CRP TNF
3	lyme disease	30.7	CFH CRP TNF
4	leptospirosis	29.9	CRP TNF
5	vasculitis	29.5	CRP MEFV TNF
6	epidemic typhus	11.5
7	trench fever	11.3
8	pediculus humanus corporis infestation	11.3
9	sodoku disease	11.0
10	tick infestation	11.0
11	multifocal choroiditis	10.2	CFH TNF
12	choroiditis	10.2	CFH TNF
13	haemophilus influenzae	10.2	CFH TNF
14	anterior uveitis	10.2	CFH TNF
15	drug reaction with eosinophilia and systemic symptoms	10.2	CRP TNF
16	salpingitis	10.2	CRP TNF
17	posterior uveitis	10.2	CFH TNF
18	burns	10.2	CRP TNF
19	melancholia	10.2	CRP TNF
20	typhoid fever	10.2	CRP TNF
21	central nervous system vasculitis	10.2	CRP TNF
22	streptococcal meningitis	10.2	CRP TNF
23	tuberculous peritonitis	10.2	CRP TNF
24	ischemic heart disease	10.2	CRP TNF
25	diverticulitis	10.2	CRP TNF
26	mycoplasma pneumoniae pneumonia	10.2	CRP TNF
27	scrub typhus	10.2	CRP TNF
28	chronic gonococcal salpingitis	10.2	TNF TNFRSF1A
29	retinitis pigmentosa 75	10.2	TNF TNFRSF1A
30	proctitis	10.2	CRP TNF
31	apnea, obstructive sleep	10.2	CRP TNF
32	bacterial sepsis	10.2	CRP TNF
33	dystrophinopathies	10.2	TNF TNFRSF1A
34	suppurative cholangitis	10.2	CRP TNF
35	pericoronitis	10.2	CRP TNFRSF1A
36	pyoderma	10.2	MEFV TNF
37	perinatal necrotizing enterocolitis	10.2	CRP TNF
38	acute salpingitis	10.2	TNF TNFRSF1A
39	spondylarthropathy	10.2	TNF TNFRSF1A
40	paratyphoid fever	10.2	CRP TNFRSF1A
41	exanthem	10.2	CRP TNF
42	systemic onset juvenile idiopathic arthritis	10.2	MEFV TNF
43	autoinflammation, panniculitis, and dermatosis syndrome	10.2	MEFV TNF
44	infective endocarditis	10.1	CRP TNF
45	post-transplant lymphoproliferative disease	10.1	TNF TNFRSF1A
46	juvenile ankylosing spondylitis	10.1	MEFV TNF
47	extrinsic cardiomyopathy	10.1	CRP TNF
48	chronic salpingitis	10.1	TNF TNFRSF1A
49	pleural disease	10.1	CRP TNF
50	lymph node disease	10.1	CRP TNF

Graphical network of the top 20 diseases related to Relapsing Fever:

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Symptoms & Phenotypes for Relapsing Fever

UMLS symptoms related to Relapsing Fever:

recurrent fevers

Sources

Drugs & Therapeutics for Relapsing Fever

Drugs for Relapsing Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Antibiotics, Antitubercular

Phase 4

Anti-Infective Agents

Phase 4,Phase 2,Phase 3

Anti-Bacterial Agents

Phase 4,Phase 2,Phase 3

Doxycycline

Approved, Investigational, Vet_approved

Phase 2, Phase 3

564-25-0

54671203

Synonyms:

(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

(4S,4AR,5S,5ar,6R,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

10597-92-9

17086-28-1 (mono-hydrate)

24390-14-5

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)

41411-66-9 (6-epimer, mono-hydrochloride)

564-25-0

5-Hydroxy-a-6-deoxytetracycline

5-Hydroxy-alpha-6-deoxytetracycline

5-hydroxy-α-6-deoxytetracycline

5-Hydroxy-α-6-deoxytetracycline

69935-17-7 (mono-hydrochloride, di-hydrate)

6a-Deoxy-5-oxytetracycline

6alpha-deoxy-5-oxytetracycline

6-alpha-deoxy-5-oxytetracycline

6alpha-Deoxy-5-oxytetracycline

6-alpha-Deoxy-5-oxytetracycline

6-Deoxyoxytetracycline

6-Deoxytetracycline

6α-deoxy-5-oxytetracycline

7164-70-7

7264-10-0

94088-85-4 (calcium salt (1:2))

AB08 (*Fosfatex)

AC1NQXW7

AC1NS4CW

AC1NUYS8

AC1O8PYM

alpha-6-Deoxy-5-hydroxytetracycline

alpha-6-Deoxyoxytetracycline

alpha-Doxycycline

Alti-Doxycycline

Anhydrous doxycycline

Apo-Doxy

Atridox

Azudoxat

BCBcMAP01_000024

BIDD:GT0146

BMY-28689

BPBio1_000951

BSPBio_000863

BSPBio_001936

BU-3839T

C06973

CHEBI:50845

CHEMBL1433

CID5281011

CID5353597

CID5463943

CID6713981

CPD001550033

D07876

DB00254

Deoxymykoin

DivK1c_000345

DMSC (*Fosfatex)

Dossiciclina

Dossiciclina [DCIT]

Doxcycline anhydrous

DOXCYCLINE ANHYDROUS

Doxiciclina

Doxiciclina [INN-Spanish]

Doxiciclina [Italian]

Doxitard

Doxivetin

DOXY

Doxy-Caps

Doxycen

Doxychel

Doxychel (TN)

Doxycin

Doxycyclin

doxycycline

Doxycycline (200mg/day) or Placebo

Doxycycline (anhydrous)

Doxycycline (INN)

Doxycycline (internal use)

Doxycycline (TN)

Doxycycline anhydrous

DOXYCYCLINE CALCIUM

Doxycycline hyclate

Doxycycline monohydrate

DOXYCYCLINE MONOHYDRATE

Doxycycline-Chinoin

Doxycyclinum

Doxycyclinum [INN-Latin]

Doxy-Puren

Doxysol

Doxy-Tabs

Doxytec

Doxytetracycline

EINECS 209-271-1

GS-3065 (*monohydrate)

HMS2090E06

HSDB 3071

Hydramycin

IDI1_000345

Investin

Jenacyclin

KBio1_000345

KBio2_001287

KBio2_003855

KBio2_006423

KBio3_001156

KBioGR_001133

KBioSS_001287

Liviatin

Lopac0_000405

LS-187766

LS-93868

MolPort-002-507-423

Monodox

Monodox (*monohydrate)

NCGC00161602-01

NCGC00161602-03

NCGC00161602-04

NCGC00167961-01

NCGC00179395-01

NINDS_000345

Novo-Doxylin

NSC633557

Nu-Doxycycline

Oracea

Prestwick0_000852

Prestwick1_000852

Prestwick2_000852

Prestwick3_000852

Ronaxan

SAM002589932

SMP1_000107

Spanor

SPBio_000246

SPBio_002784

Spectrum_000807

Spectrum2_000143

Spectrum3_000408

Spectrum4_000527

Spectrum5_000947

STOCK1N-34341

Supracyclin

UNII-334895S862

UPCMLD-DP021

UPCMLD-DP021:001

Vibramycin

Vibramycin (*monohydrate)

Vibramycin Novum

Vibramycine

Vibra-tabs

Vibravenos

Vivox (*Hyclate)

Antiparasitic Agents

Phase 2, Phase 3

Antiprotozoal Agents

Phase 2, Phase 3

Antimalarials

Phase 2, Phase 3

Caspofungin

Approved

Phase 2

179463-17-3, 162808-62-0

468682 2826718

Synonyms:

(4R,5S)-5-((2-aminoethyl)amino)-N(2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide

(4R,5S)-5-((2-Aminoethyl)amino)-N(2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(P-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide

(4R,5S)-5-((2-Aminoethyl)amino)-N(sup 2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide

[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate

1-[(4R,5S)-5-[(2-aminoethyl)amino]-N(2)-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0

1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N(2)-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin b0

162808-62-0

AC1L45LR

AC1LAHR5

AC1MCVUN

AR-1K4318

Cancidas

Cancidas (TM)

Cancidas (TN)

Capsofungin

CASPO

Caspofungin

Caspofungin (INN)

Caspofungin [INN]

Caspofungin acetate

Caspofungin MSD

CHEBI:474180

CHEMBL374999

CHEMBL499808

CID151068

CID2826718

CID468682

D07626

DB00520

HSDB 7476

L-743,872

LS-186994

LS-187303

LS-187635

M991

MK-0991

n-{(2r,6s,9s,11r,12s,14as,15s,20s,23s,25as)-12-[(2-aminoethyl)amino]-20-[(1r)-3-amino-1-hydroxypropyl]-23-[(1s,2s)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1r)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1h-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide

N-{(2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide

nchembio.184-comp7

Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]- (9CI)

UNII-F0XDI6ZL63

Miconazole

Approved, Investigational, Vet_approved

Phase 2

22916-47-8

4189

Synonyms:

(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole

1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole

1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole

1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole

1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole

1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole

1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole

1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole

22832-87-7 (NITRATE)

22916-47-8

75319-47-0

AB00053500

AC1L1HM1

Aflorix(nitrate)

AKOS001574474

Albistat(nitrate)

Andergin(nitrate)

BPBio1_000279

BRD-A82396632-001-03-0

BRD-A82396632-008-02-7

Brentan

BRN 0965511

BSPBio_000253

BSPBio_002033

CCRIS 7924

CHEBI:6923

CHEMBL91

CID4189

Conofite(nitrate)

CPD-4501

D00416

Dactarin

Daktarin iv

Daktarin IV

DB01110

DivK1c_000156

EINECS 245-324-5

Epi-Monistat(nitrate)

Esteve brand OF miconazole

Femizol-M

Florid(nitrate)

Gyno-Daktar(nitrate)

HMS1568M15

HMS2090B21

I14-14342

IDI1_000156

imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)

Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)

Janssen cilag brand OF miconazole

Janssen-cilag brand OF miconazole

Johnston and johnston brand OF miconazole nitrate

KBio1_000156

KBio2_001445

KBio2_004013

KBio2_006581

KBio3_001533

KBioGR_000581

KBioSS_001445

Lotrimin AF(nitrate)

LS-78378

MCZ

Micantin (nitrate)

Miconasil nitrate

Miconasil Nitrate

Miconazol

Miconazol [INN-Spanish]

miconazole

Miconazole

Miconazole (JP15/USP/INN)

Miconazole [USAN:BAN:INN:JAN]

Miconazole 3

Miconazole 3 Combination Pack

Miconazole 7 Combination Pack

Miconazole esteve brand

Miconazole janssen-cilag brand

Miconazole nitrate

Miconazole nitrate salt

Miconazole-7

Miconazolo

Miconazolo [DCIT]

Miconazolum

Miconazolum [INN-Latin]

Micozole

Minostate

MJR 1762

MLS002222203

MolPort-002-557-553

Monazole 7

Monista (nitrate)

Monistat

Monistat (TN)

Monistat 1 Combination Pack

Monistat 3 Dual-Pak

Monistat 3 Vaginal Ovules

Monistat 5 Tampon

Monistat 7 Dual-Pak

Monistat 7 Vaginal Suppositories

Monistat Dual- PAK

Monistat IV

Monistat iv (tn)

Monistat iv (TN)

Monistat-Derm

NCI60_001353

NCI60_001380

NINDS_000156

Nitrate, miconasil

Nitrate, miconazole

Novo-Miconazole Vaginal Ovules

NSC 170986

NSC169434

NSC170986

Oprea1_091955

Prestwick_335

Prestwick0_000067

Prestwick1_000067

Prestwick2_000067

Prestwick3_000067

R 18134

R-14,889

SMR001307249

SPBio_000976

SPBio_002174

Spectrum_000965

Spectrum2_001048

Spectrum3_000507

Spectrum4_000061

Spectrum5_001297

STK834405

STOCK1S-93556

UNII-7NNO0D7S5M

Vusion

Zimycan

Amphotericin B

Approved, Investigational

Phase 2

1397-89-3

5280965 14956

Synonyms:

12633-72-6

1397-89-3

30782-62-8

5-18-10-00525 (Beilstein Handbook Reference)

54482-28-9

8055-20-7

AB00513832

Abelcet

Abelecet

ABLC

AC1L1CN2

AC1L24V6

AC1L70KF

AC1L73U6

AC1NQXTD

AC1NTQ32

AC1NUQG4

AC1NY9JC

AC1O7GCZ

AC1O8FQV

AC1O8PFK

AI3-26528

Ambap1397-89-3

Ambisome

AmBisome (TN)

Amfotericina b

Amfotericina B

Amfotericina B [INN-Spanish]

amophotericin B

AMPH-b

AMPH-B

Amphocil

Amphocin

Amphomoronal

Ampho-Moronal

Amphortericin b

Amphortericin B

Amphotec

Amphotec (TN)

Amphotericin

Amphotericin .BETA.

amphotericin b

Amphotericin B

Amphotericin B (JP15/USP/INN)

Amphotericin B [USAN:INN:JAN]

Amphotericin b cholesterol dispersion

Amphotericin B Cholesterol Dispersion

Amphotericin b colloidal dispersion

Amphotericin B Colloidal Dispersion

amphotericin B liposomal

Amphotericin B, Lipid-based

Amphotericin B, Streptomyces sp.

Amphotericin-B

Amphotericine b

Amphotericine B

Amphotéricine B

Amphotericine B [INN-French]

Amphotericinum

Amphotericinum b

Amphotericinum B

Amphotericinum B [INN-Latin]

Amphotherizin

Amphotherizin [German]

Amphozone

BIDD:GT0351

BPBio1_000374

BRN 0078342

BSPBio_000340

C06573

C47H73NO17

C-AmB

CCRIS 5963

CHEBI:2682

CHEMBL1200646

CHEMBL267345

CID10533925

CID10629638

CID10677275

CID14956

CID1972

CID352546

CID354192

CID5280965

CID5386092

CID5458486

CID5771695

CID6604295

CID6708817

CID6713692

CID9919339

D00203

DB00681

DivK1c_007045

EINECS 215-742-2

Fungilin

Fungisome

Fungisone

Fungizone

Fungizone (TN)

Halizon

HMS1569A22

HSDB 3008

HSDB 3008 IAB

I06-0257

KBio1_001989

KBio2_000551

KBio2_003119

KBio2_005687

KBioGR_002298

KBioSS_000551

Liposomal amphotericin b

Liposomal Amphotericin B

LMPK06000002

LNS-AmB

LS-187721

LS-93

MLS002702966

MolPort-006-392-260

Mysteclin-F

NCGC00014913

NCGC00090808-01

NCGC00098014-01

NCGC00179595-01

NCI527017

NCI60_004288

NCIStruc1_001042

NCIStruc2_000920

NKTR-024

NS 718

NSC 527017

NSC527017

NSC-527017

Prestwick_721

Prestwick0_000410

Prestwick1_000410

Prestwick2_000410

Prestwick3_000410

SinuNase

SMP1_000302

SMR001566780

SPBio_000715

SPBio_002279

SpecPlus_000949

Spectrum_000111

Spectrum2_000818

Spectrum4_001779

ST50999656

UNII-7XU7A7DROE

Liposomal amphotericin B

Phase 2

Antifungal Agents

Phase 2

Echinocandins

Phase 2

Antibodies

Not Applicable

Immunoglobulins

Not Applicable

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia	Completed	NCT01581333	Phase 4	Empirical antimicrobial treatment discontinuation;Standard empirical antimicrobial treatment discontinuation
2	Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever	Completed	NCT00237016	Phase 2, Phase 3	doxycycline treatment
3	A Study of Caspofungin, Liposomal Amphotericin B or the Combination of Both for Patients After Stem-Cell Transplantation	Completed	NCT00148148	Phase 2	caspofungin;liposomal amphotericin B
4	Perifosine in Patients With Relapsed/Refractory Waldenstrom's Macroglobulinemia	Completed	NCT00422656	Phase 2	Perifosine
5	Tocilizumab in Patients With Schnitzler's Syndrome	Recruiting	NCT03046381	Phase 2	Tocilizumab
6	Life Quality Study for PFAPA Patient	Unknown status	NCT02811705
7	Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors	Completed	NCT00933296
8	Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever)	Completed	NCT01766830	Not Applicable
9	Exercise Capacity and Physical Activity Levels in Newly Diagnosed Hematologic Malignant Patients	Recruiting	NCT03212560

Search NIH Clinical Center for Relapsing Fever

Cochrane evidence based reviews: relapsing fever

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Genetic Tests for Relapsing Fever

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Anatomical Context for Relapsing Fever

MalaCards organs/tissues related to Relapsing Fever:

⁴¹

Brain, Testes, Heart, Spleen, Bone, Lymph Node, Pancreas

Sources

Publications for Relapsing Fever

Articles related to Relapsing Fever:

(show top 50) (show all 625)

#	Title	Authors	Year
1	Colony formation in solid medium by the relapsing fever spirochetes Borrelia hermsii and Borrelia turicatae. ( 29169853 )	Raffel S.J....Gherardini F.C.	2018
2	Tick-Borne Relapsing Fever with Severe Jarisch-Herxheimer Reaction. ( 29658212 )	Koton Y....Bisharat N.	2018
3	Tick-Borne Relapsing Fever with Severe Jarisch-Herxheimer Reaction. ( 29333799 )	Koton Y....Bisharat N.	2018
4	Isolation and molecular characterization of a relapsing fever Borrelia recovered from Ornithodoros rudis in Brazil. ( 29571703 )	MuA+oz-Leal S....Labruna M.B.	2018
5	Outbreak of Louse-Borne Relapsing Fever among Urban Dwellers in Arsi Zone, Central Ethiopia, from July to November 2016. ( 29692298 )	Nordmann T....HAoussinger D.	2018
6	Tick-borne relapsing fever as a potential veterinary medical problem. ( 29943903 )	Elelu N.	2018
7	Microbiological features distinguishing Lyme disease and relapsing fever spirochetes. ( 30074091 )	Bergstr?m S...Normark J	2018
8	Genome-wide analysis of Borrelia turcica and 'Candidatus Borrelia tachyglossi' shows relapsing fever-like genomes with unique genomic links to Lyme disease Borrelia. ( 30240834 )	Gofton AW...Oskam CL	2018
9	Relapsing fever in a Moroccan man. ( 29997070 )	Kahouli S...Lmimouni BE	2018
10	Transmission of the relapsing fever spirochete, Borrelia miyamotoi, by single transovarially-infected larval Ixodes scapularis ticks. ( 30007502 )	Breuner NE...Eisen L	2018
11	Novel real-time PCR assays for genomic group identification of tick-borne relapsing fever species Borrelia hermsii. ( 30131238 )	Modarelli JJ...Esteve-Gasent MD	2018
12	Vector competence of geographical populations of Ornithodoros turicata for the tick-borne relapsing fever spirochete Borrelia turicatae. ( 30143510 )	Krishnavajhala A...Lopez JE	2018
13	Detection of Tickborne Relapsing Fever Spirochete, Austin, Texas, USA. ( 30160650 )	Bissett JD...Lopez JE	2018
14	Genomic blueprint of a relapsing fever pathogen in 15th century Scandinavia. ( 30249639 )	Guellil M...Bramanti B	2018
15	Relapsing fever Borrelia in California: a pilot serological study. ( 30288084 )	Middelveen MJ...Stricker RB	2018
16	Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas. ( 30372445 )	Armstrong BA...Lopez JE	2018
17	Human Borreliosis Caused by a New World Relapsing Fever Borrelia-like Organism in the Old World. ( 30423022 )	Qiu Y...Kawabata H	2018
18	The relapsing fever spirochete Borrelia turicatae persists in the highly oxidative environment of its soft-bodied tick vector. ( 30489694 )	Bourret TJ...Lopez JE	2018
19	An immunocompromised mouse model to infect Ixodes scapularis ticks with the relapsing fever spirochete, Borrelia miyamotoi. ( 30503357 )	Lynn GE...Eisen RJ	2018
20	In Vitro Susceptibility of the Relapsing-Fever Spirochete Borrelia miyamotoi to Antimicrobial Agents. ( 28674060 )	Koetsveld J....Hovius J.W.	2017
21	Ecological niche modeling and distribution of Ornithodoros hermsi associated with tick-borne relapsing fever in western North America. ( 29084219 )	Sage K.M....Schwan T.G.	2017
22	Relapsing fever causative agent in Southern Iran is a closely related species to East African borreliae. ( 28736193 )	Naddaf S.R....Cutler S.J.	2017
23	There Is a Method to the Madness: Strategies to Study Host Complement Evasion by Lyme Disease and Relapsing Fever Spirochetes. ( 28303129 )	Marcinkiewicz A.L....Lin Y.P.	2017
24	Division of the genus Borrelia into two genera (corresponding to Lyme disease and relapsing fever groups) reflects their genetic and phenotypic distinctiveness and will lead to a better understanding of these two groups of microbes (Margos et al. (2016) There is inadequate evidence to support the division of the genus Borrelia. Int. J. Syst. Evol. Microbiol. doi: 10.1099/ijsem.0.001717). ( 28141502 )	Barbour A.G....Gupta R.S.	2017
25	Serological detection of Tick-Borne Relapsing Fever in Texan domestic dogs. ( 29232415 )	Esteve-Gasent M.D....Piccione J.	2017
26	Diagnosis of Louse-Borne Relapsing Fever despite Negative Microscopy in Two Asylum Seekers from Eastern Africa. ( 29016302 )	Antinori S....Mediannikov O.	2017
27	Development and optimization of an inA vitro cultivation protocol allows for isolation of Borrelia miyamotoi from patients with hard tick-borne relapsing fever. ( 28110053 )	Koetsveld J....Hovius J.W.	2017
28	Host Immune Evasion by Lyme and Relapsing Fever Borreliae: Findings to Lead Future Studies for Borrelia miyamotoi. ( 28154563 )	Stone B.L....Brissette C.A.	2017
29	Louse-borne relapsing fever in Finland in two asylum seekers from Somalia. ( 27859692 )	HytAPnen J....Oksi J.	2017
30	A relapsing fever group Borrelia sp. is widely distributed among wild deer in Japan. ( 29329785 )	Kumagai Y....Kawabata H.	2017
31	Epidemiological study of relapsing fever borreliae detected in Haemaphysalis ticks and wild animals in the western part of Japan. ( 28362864 )	Furuno K....Takano A.	2017
32	Crystal Structure of Borrelia turicatae protein, BTA121, a differentially regulated A gene in the tick-mammalian transmission cycle of relapsing fever spirochetes. ( 29127407 )		2017
33	Relapsing fever in young refugees from East Africa. ( 28774320 )		2017
34	Plasmodium falciparum malaria co-infection with tick-borne relapsing fever in Dakar. ( 28077149 )		2017
35	Relapsing Fever ( 28722942 )		2017
36	Identification and characterization of a histamine-binding lipocalin-like molecule from the relapsing fever tick Ornithodoros turicata. ( 29164729 )		2017
37	Louse-borne relapsing fever in a refugee from Mali. ( 28161771 )	Grecchi C...Castelli F	2017
38	Transmission of Borrelia miyamotoi sensu lato relapsing fever group spirochetes in relation to duration of attachment by Ixodes scapularis nymphs. ( 28501504 )	Breuner NE...Eisen L	2017
39	Detection of relapsing fever Borrelia spp., Bartonella spp. and Anaplasmataceae bacteria in argasid ticks in Algeria. ( 29145396 )	Lafri I...Parola P	2017
40	Louse-Borne Relapsing Fever (Borrelia recurrentis) in a Somali Refugee Arriving in Italy: A Re-emerging Infection in Europe? ( 27149282 )	Antinori S....Rimoldi S.G.	2016
41	Regarding Tick-Borne Relapsing Fever in the Americas; Some Historical Aspects of a Forgotten Disease in Colombia. ( 29056741 )	Faccini-MartA-nez A.8.A....Botero-GarcA-a C.A.	2016
42	Molecular identification of Borrelia genus in questing hard ticks from Portugal: Phylogenetic characterization of two novel Relapsing Fever-like Borrelia sp. ( 26976475 )	Nunes M....Vieira M.L.	2016
43	Louseborne Relapsing Fever among East African Refugees, Italy, 2015. ( 26812354 )	Lucchini A....Di Perri G.	2016
44	Detection and Characterization of the Emerging Relapsing Fever Pathogen, Borrelia miyamotoi, from the Ixodes ricinus Tick in the Rural Trakya (Thrace) Region of Northwestern Turkey. ( 27788060 )	Sakakibara K....Masuzawa T.	2016
45	Tick-Borne Relapsing Fever in Dogs. ( 27353196 )	Piccione J....Esteve-Gassent M.D.	2016
46	Where Are the Ticks? Solving the Mystery of a Tickborne Relapsing Fever Outbreak at a Youth Camp. ( 27188066 )	Gaither M....Maurer M.	2016
47	Tick-Borne Relapsing Fever, Southern Spain, 2004-2015. ( 27442975 )	Castilla-Guerra L....Colmenero-Camacho M.A.	2016
48	Relapsing fever in asylum seekers from Somalia arriving in Belgium in August 2015. ( 27112219 )	Costescu Strachinaru D.I....Konopnicki D.	2016
49	Correction: Expression of the Tick-Associated Vtp Protein of Borrelia hermsii in a Murine Model of Relapsing Fever. ( 27074024 )	Marcsisin R.A....Barbour A.G.	2016
50	Tick-Borne Relapsing Fever Spirochetes in the Americas. ( 28959690 )	Lopez J.E....Bermudez S.	2016

Sources

Genes for Relapsing Fever

Genes related to Relapsing Fever (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MVK	Mevalonate Kinase	Protein Coding	24.3	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	15536479 19644432 17804452 (more) 19531764 15037710
2	CFH	Complement Factor H	Protein Coding	21.87	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	19604355
3	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	21.59	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	11953985 10902757 15071491 (more) 11175303 13130484 15280569
4	TNF	Tumor Necrosis Factor	Protein Coding	20.68	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	MEFV	MEFV, Pyrin Innate Immunity Regulator	Protein Coding	19.57	Novoseek inferred ⁵⁵	15071491 16255051
6	CRP	C-Reactive Protein	Protein Coding	16.59	GeneCards inferred via : Publications (show sections)
7	ARSI	Arylsulfatase Family Member I	Protein Coding	16.47	DISEASES inferred ¹⁵
8	CLPX	Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit	Protein Coding	16.24	DISEASES inferred ¹⁵
9	PURA	Purine Rich Element Binding Protein A	Protein Coding	15.93	DISEASES inferred ¹⁵

Sources

Variations for Relapsing Fever

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Expression for Relapsing Fever

Search GEO for disease gene expression data for Relapsing Fever.

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Pathways for Relapsing Fever

Pathways related to Relapsing Fever according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Transcription_NF-kB signaling pathway ²²	11.19	TNF TNFRSF1A
2	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.14	TNF TNFRSF1A
3	Cellular Transformation by HTLV1 ⁶⁴ Show member pathways Activation of NF-KappaB by PKR ⁶⁴	11.1	TNF TNFRSF1A
4	Interleukin-10 signaling ⁶⁶	11.06	TNF TNFRSF1A
5	Ceramide signaling pathway ¹	10.97	TNF TNFRSF1A
6	Signal transduction_JNK pathway ²²	10.9	TNF TNFRSF1A
7	14-3-3 and Regulation of BAD Activity ⁶⁴	10.66	TNF TNFRSF1A
8	Canonical NF-kappaB pathway ¹	10.32	TNF TNFRSF1A
9	Overview of nanoparticle effects ¹	9.9	CRP TNF

Sources

GO Terms for Relapsing Fever

Biological processes related to Relapsing Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	9.67	CRP MEFV TNF TNFRSF1A
2	negative regulation of inflammatory response	GO:0050728	9.5	MEFV MVK TNFRSF1A
3	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.46	TNF TNFRSF1A
4	extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	9.43	TNF TNFRSF1A
5	regulation of tumor necrosis factor-mediated signaling pathway	GO:0010803	9.4	TNF TNFRSF1A
6	negative regulation of lipid storage	GO:0010888	9.26	CRP TNF
7	positive regulation of ceramide biosynthetic process	GO:2000304	9.16	TNF TNFRSF1A
8	death-inducing signaling complex assembly	GO:0071550	8.96	TNF TNFRSF1A
9	regulation of establishment of endothelial barrier	GO:1903140	8.62	TNF TNFRSF1A

Molecular functions related to Relapsing Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.28	ARSI CFH CLPX CRP MEFV MVK

Sources

Sources for Relapsing Fever

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹⁶ DrugBank

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¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia