MCID: RLP003
MIFTS: 50

Relapsing Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Relapsing Fever

MalaCards integrated aliases for Relapsing Fever:

Name: Relapsing Fever 12 58 54 44 15 70

Characteristics:

Orphanet epidemiological data:

58
relapsing fever
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Relapsing Fever

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Borrelia, which is transmitted by tick or transmitted by body louse.

MalaCards based summary : Relapsing Fever is related to epidemic typhus and louse-borne relapsing fever, and has symptoms including recurrent fevers An important gene associated with Relapsing Fever is CFH (Complement Factor H), and among its related pathways/superpathways are Tuberculosis and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Doxycycline and Antimalarials have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and liver, and related phenotypes are fever and thrombocytopenia

Wikipedia : 73 Relapsing fever is a vector-borne disease caused by infection with certain bacteria in the genus... more...

Related Diseases for Relapsing Fever

Diseases related to Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 286)
# Related Disease Score Top Affiliating Genes
1 epidemic typhus 32.0 TNF HSPD1 CRP
2 louse-borne relapsing fever 31.3 TNF CYP26A1 CRP CFH C4B C4A
3 tick-borne relapsing fever 30.9 CYP26A1 CLPX CFHR2 CCDC85B C4B C4A
4 exanthem 30.6 TNF MVK MEFV CRP
5 typhoid fever 30.6 TNFRSF1A TNF CRP
6 haemophilus influenzae 30.3 TNF CFH
7 disseminated intravascular coagulation 30.2 TNF PLG CRP
8 facial paralysis 30.1 TNF PLG CRP
9 brucellosis 30.1 TNF MEFV CRP
10 uveitis 30.1 TNFRSF1A TNF HSPD1
11 disease by infectious agent 30.1 TNFRSF1A TNF HSPD1 CRP CFHR2
12 scarlet fever 30.0 TNF CRP C3
13 meningitis 29.9 TNF CRP C3
14 endophthalmitis 29.9 TNF PLG CRP
15 thrombocytopenia 29.8 TNFRSF1A TNF PLG CRP CFH C3
16 lyme disease 29.8 YBX3 TNF HSPD1 CRP CFHR2 CFH
17 purpura 29.8 TNF MEFV CRP C3
18 malaria 29.6 TNFRSF1A TNF PLG HSPD1 CRP CFH
19 bacterial infectious disease 29.5 TNF HSPD1 CRP CFHR2 C4A
20 hemolytic anemia 29.5 TNFRSF1A TNF CFH C3
21 vasculitis 29.4 TNF MEFV HSPD1 CRP C3
22 tick infestation 11.0
23 trench fever 11.0
24 sodoku disease 11.0
25 pediculus humanus corporis infestation 11.0
26 drug reaction with eosinophilia and systemic symptoms 10.4 TNF CRP
27 multifocal choroiditis 10.4 TNF CFH
28 anterior scleritis 10.4 TNF CRP
29 rheumatoid arthritis interstitial lung disease 10.4 TNF CRP
30 posterior scleritis 10.4 TNF CRP
31 tuberculous epididymitis 10.4 TNF CRP
32 meningovascular neurosyphilis 10.4 TNF CRP
33 critical illness polyneuropathy 10.4 TNF CRP
34 inflammatory myopathy with abundant macrophages 10.4 TNFRSF1A MEFV
35 exudative glomerulonephritis 10.4 CFHR2 CFH
36 juvenile ankylosing spondylitis 10.4 TNF MEFV
37 tertiary syphilis 10.4 TNF CRP
38 intermittent hydrarthrosis 10.4 TNFRSF1A MEFV
39 hydrarthrosis 10.4 TNFRSF1A MEFV
40 arachnoiditis 10.4 TNF CRP
41 soft tissue sarcoma 10.4 TNF CRP
42 gastrointestinal tuberculosis 10.4 TNF CRP
43 intestinal tuberculosis 10.4 TNF CRP
44 idiopathic recurrent pericarditis 10.4 TNFRSF1A MEFV
45 cerebritis 10.4 TNF CRP
46 aspiration pneumonitis 10.4 TNF CRP
47 inflammatory and toxic neuropathy 10.4 TNF CRP
48 amyloidosis aa 10.4 MEFV CRP
49 granulomatous hepatitis 10.4 TNF CRP
50 chromophil adenoma of the kidney 10.4 TNFRSF1A TNF

Graphical network of the top 20 diseases related to Relapsing Fever:



Diseases related to Relapsing Fever

Symptoms & Phenotypes for Relapsing Fever

Human phenotypes related to Relapsing Fever:

58 31 (show all 33)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
2 thrombocytopenia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001873
3 elevated c-reactive protein level 58 31 hallmark (90%) Very frequent (99-80%) HP:0011227
4 increased total bilirubin 58 31 hallmark (90%) Very frequent (99-80%) HP:0003573
5 anemia 58 31 frequent (33%) Frequent (79-30%) HP:0001903
6 elevated hepatic transaminase 58 31 frequent (33%) Frequent (79-30%) HP:0002910
7 jaundice 58 31 frequent (33%) Frequent (79-30%) HP:0000952
8 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
9 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
10 leukocytosis 58 31 frequent (33%) Frequent (79-30%) HP:0001974
11 increased lactate dehydrogenase level 31 frequent (33%) HP:0025435
12 hypotension 58 31 occasional (7.5%) Occasional (29-5%) HP:0002615
13 vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002013
14 fatigue 58 31 occasional (7.5%) Occasional (29-5%) HP:0012378
15 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
16 arthralgia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002829
17 cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0012735
18 tachycardia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001649
19 leukopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001882
20 acute kidney injury 58 31 occasional (7.5%) Occasional (29-5%) HP:0001919
21 elevated serum creatinine 58 31 occasional (7.5%) Occasional (29-5%) HP:0003259
22 chills 58 31 occasional (7.5%) Occasional (29-5%) HP:0025143
23 nuchal rigidity 58 31 occasional (7.5%) Occasional (29-5%) HP:0031179
24 hematuria 58 31 very rare (1%) Very rare (<4-1%) HP:0000790
25 hemoptysis 58 31 very rare (1%) Very rare (<4-1%) HP:0002105
26 epistaxis 58 31 very rare (1%) Very rare (<4-1%) HP:0000421
27 prolonged prothrombin time 58 31 very rare (1%) Very rare (<4-1%) HP:0008151
28 diarrhea 58 31 very rare (1%) Very rare (<4-1%) HP:0002014
29 neutrophilia 58 31 very rare (1%) Very rare (<4-1%) HP:0011897
30 hyperfibrinogenemia 58 31 very rare (1%) Very rare (<4-1%) HP:0011899
31 abnormality of the urinary system 58 Occasional (29-5%)
32 abnormal bleeding 58 Occasional (29-5%)
33 increased lactate dehydrogenase activity 58 Frequent (79-30%)

UMLS symptoms related to Relapsing Fever:


recurrent fevers

MGI Mouse Phenotypes related to Relapsing Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 ADSL C3 C4B CFH CRP CYP26A1
2 mortality/aging MP:0010768 9.97 ADSL C3 C4B CFH CLPX CYP26A1
3 embryo MP:0005380 9.91 ADSL C3 CLPX CYP26A1 HSPD1 MVK
4 nervous system MP:0003631 9.7 ADSL C3 CFH CLPX CYP26A1 HSPD1
5 reproductive system MP:0005389 9.28 C3 CYP26A1 HSPD1 MEFV MVK PLG

Drugs & Therapeutics for Relapsing Fever

Drugs for Relapsing Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
2 Antimalarials Phase 2, Phase 3
3 Antiparasitic Agents Phase 2, Phase 3
4 Anti-Bacterial Agents Phase 2, Phase 3
5 Anti-Infective Agents Phase 2, Phase 3
6 Antiprotozoal Agents Phase 2, Phase 3
7 Immunoglobulins
8 Immunoglobulin M
9 Immunoglobulin G
10 Immunoglobulins, Intravenous
11 Antibodies
12 Immunologic Factors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever Completed NCT00237016 Phase 2, Phase 3 doxycycline treatment
2 Evaluation of Rapid Diagnostic Tests (RDT) in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases (NTD) in Patients Presenting With Persistent Fever (≥1 Week) in Cambodia, Nepal, Democratic Republic of the Congo and Sudan Completed NCT01766830

Search NIH Clinical Center for Relapsing Fever

Cochrane evidence based reviews: relapsing fever

Genetic Tests for Relapsing Fever

Anatomical Context for Relapsing Fever

MalaCards organs/tissues related to Relapsing Fever:

40
Brain, Kidney, Liver, Spleen, Heart, Skin, Bone Marrow

Publications for Relapsing Fever

Articles related to Relapsing Fever:

(show top 50) (show all 1410)
# Title Authors PMID Year
1
Complement factor H binding by different Lyme disease and relapsing fever Borrelia in animals and human. 61 54
19604355 2009
2
First detection of Borrelia miyamotoi infections in ticks and humans from the northeast of Inner Mongolia, China. 61
33582142 2021
3
Aggregation of data from 4 clinical studies demonstrating efficacy of single-dose doxycycline postexposure for prevention of the spirochetal infections: Lyme disease, syphilis, and tick-borne relapsing fever. 61
33360515 2021
4
Borrelia miyamotoi infection in Apodemus spp. mice populating an urban habitat (Warsaw, Poland). 61
33643840 2021
5
Postexposure prophylaxis with single-dose doxycycline is effective for prevention of Lyme disease in both the United States and Europe and is also effective for prevention of syphilis and tick-borne relapsing fever. 61
33780744 2021
6
A case of COVID-19 diagnosed with favipiravir induced drug fever based on positive drug-induced lymphocyte stimulation test. 61
33746092 2021
7
Survey on tick distribution and tick-borne pathogens in Daejeon and adjacent areas in South Korea. 61
33774480 2021
8
Detection of Tick-Borne Pathogens in Ticks from Dogs and Cats in the Yamagata Prefecture of Japan in 2018. 61
32863354 2021
9
Acute infection as cause of hospitalization of asylum-seeking children and adolescents in Stockholm, Sweden 2015-2016. 61
32974759 2021
10
Molecular detection and phylogenetic analysis of Borrelia miyamotoi strains from ticks collected in the capital region of Finland. 61
33249364 2021
11
Human-pathogenic relapsing fever Borrelia found in bats from Central China phylogenetically clustered together with relapsing fever borreliae reported in the New World. 61
33735240 2021
12
Louse-borne relapsing fever-A systematic review and analysis of the literature: Part 1-Epidemiology and diagnostic aspects. 61
33705384 2021
13
Louse-borne relapsing fever-A systematic review and analysis of the literature: Part 2-Mortality, Jarisch-Herxheimer reaction, impact on pregnancy. 61
33705387 2021
14
Transmission of the human relapsing fever spirochete Borrelia persica by the argasid tick Ornithodoros tholozani involves blood meals from wildlife animal reservoirs and mainly transstadial transfer. 61
33741637 2021
15
Interaction between Borrelia miyamotoi variable major proteins Vlp15/16 and Vlp18 with plasminogen and complement. 61
33654183 2021
16
Vitronectin binding protein, BOM1093, confers serum resistance on Borrelia miyamotoi. 61
33750855 2021
17
RNA-seq analysis and gene expression dynamics in the salivary glands of the argasid tick Ornithodoros erraticus along the trophogonic cycle. 61
33743776 2021
18
Borrelia in neotropical bats: Detection of two new phylogenetic lineages. 61
33388557 2021
19
Relapsing fever in a traveller returning from Senegal. 61
33619068 2021
20
Protection against severe infectious disease in the past. 61
33573529 2021
21
Pathogen Coinfections Harbored by Adult Ixodes scapularis from White-Tailed Deer Compared with Questing Adults Across Sites in Maryland, USA. 61
33316206 2021
22
Sialotranscriptomics of the argasid tick Ornithodoros moubata along the trophogonic cycle. 61
33544727 2021
23
Human dental pulp stem cells: A sanctuary for relapsing Bartonella quintana. 61
33609646 2021
24
Novel Borrelia genotypes in bats from the Macaregua Cave, Colombia. 61
33226201 2021
25
Molecular detection of pathogens from ectoparasites recovered from peri-domestic animals, and the first description of a Candidatus Midichloria sp. from Haemaphysalis wellingtoni from rural communities in Malaysia. 61
33038482 2021
26
Borrelia miyamotoi-An Emerging Human Tick-Borne Pathogen in Europe. 61
33445492 2021
27
Pathogenesis of Relapsing Fever. 61
33372163 2021
28
Relapsing Fever Group Borreliae in Human-Biting Soft Ticks, Brazil. 61
33350927 2021
29
Quantitative real-time PCR in Borrelia persica tick-borne relapsing fever demonstrates correlation with the Jarisch-Herxheimer reaction. 61
33394211 2021
30
Isolation of Borrelia miyamotoi and other Borreliae using a modified BSK medium. 61
33479281 2021
31
Spatial variability in prevalence and genospecies distributions of Borrelia burgdorferi sensu lato from ixodid ticks collected in southern Germany. 61
33096511 2021
32
Evolutionary Genetics of Borrelia. 61
33289682 2021
33
Perpetuation of Borreliae. 61
33300495 2021
34
Borrelia miyamotoi strain LB-2001 retains plasmids and infectious phenotype throughout continuous culture passages as evaluated by multiplex PCR. 61
33074149 2021
35
Seasonality of acarological risk of exposure to Borrelia miyamotoi from questing life stages of Ixodes scapularis collected from Wisconsin and Massachusetts, USA. 61
33035757 2021
36
Spatial and temporal patterns of the emerging tick-borne pathogen Borrelia miyamotoi in blacklegged ticks (Ixodes scapularis) in New York. 61
33446237 2021
37
Genetic Manipulation of Borrelia. 61
33300496 2021
38
An outbreak of relapsing fever unmasked by microbial paleoserology, 16th century, France. 61
32959380 2020
39
Pathogenic New World Relapsing Fever Borrelia in a Myotis Bat, Eastern China, 2015. 61
33219789 2020
40
Cat Scratch Disease Presenting as Fever of Unknown Origin Is a Unique Clinical Syndrome. 61
31758684 2020
41
Detection of Asian-Type Borrelia miyamotoi from Ixodes ricinus Inhabiting Tver Province (Russia): A Sympatric Region for I. ricinus and Ixodes persulcatus. 61
32762621 2020
42
Identification and functional analysis of ferritin 2 from the Taiga tick Ixodes persulcatus Schulze. 61
32993953 2020
43
Molecular detection of a Borrelia sp. in nymphs of Amblyomma brasiliense ticks (Acari: Ixodidae) from Iguaçu National Park, Brazil, genetically related to Borrelia from Ethiopia and Côte d'Ivoire. 61
32993939 2020
44
Infection of hard ticks in the Caspian Sea littoral of Iran with Lyme borreliosis and relapsing fever borreliae. 61
32993956 2020
45
Doxycycline for Prevention of Spirochetal Infections: Status Report. 61
32157268 2020
46
Glycerophosphodiester Phosphodiesterase Identified as Non-Reliable Serological Marker for Borrelia miyamotoi Disease. 61
33255178 2020
47
Detection of Borreliaburgdorferi Sensu Lato and Relapsing Fever Borrelia in Feeding Ixodes Ticks and Rodents in Sarawak, Malaysia: New Geographical Records of Borrelia yangtzensis and Borrelia miyamotoi. 61
33076567 2020
48
Tickborne Relapsing Fever, Jerusalem, Israel, 2004-2018. 61
32946718 2020
49
A case of tick-borne relapsing fever in pregnancy. 61
33316012 2020
50
Single Dose of Doxycycline for the Prevention of Tick-borne Relapsing Fever. 61
31955197 2020

Variations for Relapsing Fever

Expression for Relapsing Fever

Search GEO for disease gene expression data for Relapsing Fever.

Pathways for Relapsing Fever

Pathways related to Relapsing Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.96 TNFRSF1A TNF HSPD1 C3
2 11.88 TNF HSPD1 C4B C4A
3
Show member pathways
11.85 CRP CFH C4B C4A C3
4
Show member pathways
11.72 CRP CFH C4B C4A C3
5
Show member pathways
11.56 C4B C4A C3
6 11.5 TNF C4B C4A C3
7 11.39 TNF HSPD1 C3
9 11.34 PLG CFH C4B C4A C3
10 11.26 PLG CFHR2 CFH C4B C4A C3

GO Terms for Relapsing Fever

Cellular components related to Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 TNFRSF1A TNF PLG CRP CFHR2 CFH
2 cell surface GO:0009986 9.65 TNFRSF1A TNF PLG HSPD1 C3
3 extracellular space GO:0005615 9.61 TNFRSF1A TNF PLG HSPD1 CRP CFH
4 blood microparticle GO:0072562 9.02 PLG CFH C4B C4A C3

Biological processes related to Relapsing Fever according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.8 MEFV CRP CFH C4B C4A C3
2 positive regulation of inflammatory response GO:0050729 9.7 TNFRSF1A TNF HSPD1
3 complement activation, classical pathway GO:0006958 9.67 CRP C4B C4A C3
4 complement activation GO:0006956 9.56 CFH C4B C4A C3
5 regulation of complement activation GO:0030449 9.55 CFHR2 CFH C4B C4A C3
6 complement activation, alternative pathway GO:0006957 9.54 CFH C3
7 positive regulation of ceramide biosynthetic process GO:2000304 9.51 TNFRSF1A TNF
8 regulation of establishment of endothelial barrier GO:1903140 9.49 TNFRSF1A TNF
9 negative regulation of lipid storage GO:0010888 9.48 TNF CRP
10 death-inducing signaling complex assembly GO:0071550 9.46 TNFRSF1A TNF
11 opsonization GO:0008228 9.43 CRP C4B
12 interaction with symbiont GO:0051702 9.4 PLG HSPD1
13 inflammatory response GO:0006954 9.17 TNFRSF1A TNF MEFV CRP C4B C4A
14 positive regulation of apoptotic cell clearance GO:2000427 9.13 C4B C4A C3

Molecular functions related to Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.56 TNFRSF1A TNF MVK MEFV CRP CFHR2
2 apolipoprotein binding GO:0034185 9.26 PLG HSPD1
3 complement component C1q binding GO:0001849 9.16 CRP C4A
4 endopeptidase inhibitor activity GO:0004866 8.8 C4B C4A C3

Sources for Relapsing Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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