MCID: RLP003
MIFTS: 42

Relapsing Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Relapsing Fever

MalaCards integrated aliases for Relapsing Fever:

Name: Relapsing Fever 12 59 55 44 15 73

Characteristics:

Orphanet epidemiological data:

59
relapsing fever
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:13034
ICD10 33 A68 A68.9
ICD9CM 35 087 087.9
MeSH 44 D012061
SNOMED-CT 68 46107006
Orphanet 59 ORPHA91547
MESH via Orphanet 45 D012061
UMLS via Orphanet 74 C0035021
ICD10 via Orphanet 34 A68.0 A68.1 A68.9
UMLS 73 C0035021

Summaries for Relapsing Fever

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, has material basis in Borrelia, which is transmitted by tick or transmitted by body louse.

MalaCards based summary : Relapsing Fever is related to tick-borne relapsing fever and louse-borne relapsing fever, and has symptoms including recurrent fevers An important gene associated with Relapsing Fever is MVK (Mevalonate Kinase), and among its related pathways/superpathways are Transcription_NF-kB signaling pathway and Photodynamic therapy-induced AP-1 survival signaling.. The drugs Antibiotics, Antitubercular and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart.

Wikipedia : 76 Relapsing fever is a vector-born disease caused by infection with certain bacteria in the genus... more...

Related Diseases for Relapsing Fever

Diseases related to Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 tick-borne relapsing fever 34.1 CLPX PURA
2 louse-borne relapsing fever 34.1 ARSI CRP TNF
3 lyme disease 30.7 CFH CRP TNF
4 leptospirosis 29.9 CRP TNF
5 vasculitis 29.5 CRP MEFV TNF
6 epidemic typhus 11.5
7 trench fever 11.3
8 pediculus humanus corporis infestation 11.3
9 sodoku disease 11.0
10 tick infestation 11.0
11 multifocal choroiditis 10.2 CFH TNF
12 choroiditis 10.2 CFH TNF
13 haemophilus influenzae 10.2 CFH TNF
14 anterior uveitis 10.2 CFH TNF
15 drug reaction with eosinophilia and systemic symptoms 10.2 CRP TNF
16 salpingitis 10.2 CRP TNF
17 posterior uveitis 10.2 CFH TNF
18 burns 10.2 CRP TNF
19 melancholia 10.2 CRP TNF
20 typhoid fever 10.2 CRP TNF
21 central nervous system vasculitis 10.2 CRP TNF
22 streptococcal meningitis 10.2 CRP TNF
23 tuberculous peritonitis 10.2 CRP TNF
24 ischemic heart disease 10.2 CRP TNF
25 diverticulitis 10.2 CRP TNF
26 mycoplasma pneumoniae pneumonia 10.2 CRP TNF
27 scrub typhus 10.2 CRP TNF
28 chronic gonococcal salpingitis 10.2 TNF TNFRSF1A
29 retinitis pigmentosa 75 10.2 TNF TNFRSF1A
30 proctitis 10.2 CRP TNF
31 apnea, obstructive sleep 10.2 CRP TNF
32 bacterial sepsis 10.2 CRP TNF
33 dystrophinopathies 10.2 TNF TNFRSF1A
34 suppurative cholangitis 10.2 CRP TNF
35 pericoronitis 10.2 CRP TNFRSF1A
36 pyoderma 10.2 MEFV TNF
37 perinatal necrotizing enterocolitis 10.2 CRP TNF
38 acute salpingitis 10.2 TNF TNFRSF1A
39 spondylarthropathy 10.2 TNF TNFRSF1A
40 paratyphoid fever 10.2 CRP TNFRSF1A
41 exanthem 10.2 CRP TNF
42 systemic onset juvenile idiopathic arthritis 10.2 MEFV TNF
43 autoinflammation, panniculitis, and dermatosis syndrome 10.2 MEFV TNF
44 infective endocarditis 10.1 CRP TNF
45 post-transplant lymphoproliferative disease 10.1 TNF TNFRSF1A
46 juvenile ankylosing spondylitis 10.1 MEFV TNF
47 extrinsic cardiomyopathy 10.1 CRP TNF
48 chronic salpingitis 10.1 TNF TNFRSF1A
49 pleural disease 10.1 CRP TNF
50 lymph node disease 10.1 CRP TNF

Graphical network of the top 20 diseases related to Relapsing Fever:



Diseases related to Relapsing Fever

Symptoms & Phenotypes for Relapsing Fever

UMLS symptoms related to Relapsing Fever:


recurrent fevers

Drugs & Therapeutics for Relapsing Fever

Drugs for Relapsing Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibiotics, Antitubercular Phase 4
2 Anti-Infective Agents Phase 4,Phase 2,Phase 3
3 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
4
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
5 Antiparasitic Agents Phase 2, Phase 3
6 Antiprotozoal Agents Phase 2, Phase 3
7 Antimalarials Phase 2, Phase 3
8
Caspofungin Approved Phase 2 179463-17-3, 162808-62-0 468682 2826718
9
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
10
Amphotericin B Approved, Investigational Phase 2 1397-89-3 5280965 14956
11 Liposomal amphotericin B Phase 2
12 Antifungal Agents Phase 2
13 Echinocandins Phase 2
14 Antibodies Not Applicable
15 Immunoglobulins Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia Completed NCT01581333 Phase 4 Empirical antimicrobial treatment discontinuation;Standard empirical antimicrobial treatment discontinuation
2 Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever Completed NCT00237016 Phase 2, Phase 3 doxycycline treatment
3 A Study of Caspofungin, Liposomal Amphotericin B or the Combination of Both for Patients After Stem-Cell Transplantation Completed NCT00148148 Phase 2 caspofungin;liposomal amphotericin B
4 Perifosine in Patients With Relapsed/Refractory Waldenstrom's Macroglobulinemia Completed NCT00422656 Phase 2 Perifosine
5 Tocilizumab in Patients With Schnitzler's Syndrome Recruiting NCT03046381 Phase 2 Tocilizumab
6 Life Quality Study for PFAPA Patient Unknown status NCT02811705
7 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
8 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830 Not Applicable
9 Exercise Capacity and Physical Activity Levels in Newly Diagnosed Hematologic Malignant Patients Recruiting NCT03212560

Search NIH Clinical Center for Relapsing Fever

Cochrane evidence based reviews: relapsing fever

Genetic Tests for Relapsing Fever

Anatomical Context for Relapsing Fever

MalaCards organs/tissues related to Relapsing Fever:

41
Brain, Testes, Heart, Spleen, Bone, Lymph Node, Pancreas

Publications for Relapsing Fever

Articles related to Relapsing Fever:

(show top 50) (show all 625)
# Title Authors Year
1
Colony formation in solid medium by the relapsing fever spirochetes Borrelia hermsii and Borrelia turicatae. ( 29169853 )
2018
2
Tick-Borne Relapsing Fever with Severe Jarisch-Herxheimer Reaction. ( 29658212 )
2018
3
Tick-Borne Relapsing Fever with Severe Jarisch-Herxheimer Reaction. ( 29333799 )
2018
4
Isolation and molecular characterization of a relapsing fever Borrelia recovered from Ornithodoros rudis in Brazil. ( 29571703 )
2018
5
Outbreak of Louse-Borne Relapsing Fever among Urban Dwellers in Arsi Zone, Central Ethiopia, from July to November 2016. ( 29692298 )
2018
6
Tick-borne relapsing fever as a potential veterinary medical problem. ( 29943903 )
2018
7
Microbiological features distinguishing Lyme disease and relapsing fever spirochetes. ( 30074091 )
2018
8
Genome-wide analysis of Borrelia turcica and 'Candidatus Borrelia tachyglossi' shows relapsing fever-like genomes with unique genomic links to Lyme disease Borrelia. ( 30240834 )
2018
9
Relapsing fever in a Moroccan man. ( 29997070 )
2018
10
Transmission of the relapsing fever spirochete, Borrelia miyamotoi, by single transovarially-infected larval Ixodes scapularis ticks. ( 30007502 )
2018
11
Novel real-time PCR assays for genomic group identification of tick-borne relapsing fever species Borrelia hermsii. ( 30131238 )
2018
12
Vector competence of geographical populations of Ornithodoros turicata for the tick-borne relapsing fever spirochete Borrelia turicatae. ( 30143510 )
2018
13
Detection of Tickborne Relapsing Fever Spirochete, Austin, Texas, USA. ( 30160650 )
2018
14
Genomic blueprint of a relapsing fever pathogen in 15th century Scandinavia. ( 30249639 )
2018
15
Relapsing fever Borrelia in California: a pilot serological study. ( 30288084 )
2018
16
Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas. ( 30372445 )
2018
17
Human Borreliosis Caused by a New World Relapsing Fever Borrelia-like Organism in the Old World. ( 30423022 )
2018
18
The relapsing fever spirochete Borrelia turicatae persists in the highly oxidative environment of its soft-bodied tick vector. ( 30489694 )
2018
19
An immunocompromised mouse model to infect Ixodes scapularis ticks with the relapsing fever spirochete, Borrelia miyamotoi. ( 30503357 )
2018
20
In Vitro Susceptibility of the Relapsing-Fever Spirochete Borrelia miyamotoi to Antimicrobial Agents. ( 28674060 )
2017
21
Ecological niche modeling and distribution of Ornithodoros hermsi associated with tick-borne relapsing fever in western North America. ( 29084219 )
2017
22
Relapsing fever causative agent in Southern Iran is a closely related species to East African borreliae. ( 28736193 )
2017
23
There Is a Method to the Madness: Strategies to Study Host Complement Evasion by Lyme Disease and Relapsing Fever Spirochetes. ( 28303129 )
2017
24
Division of the genus Borrelia into two genera (corresponding to Lyme disease and relapsing fever groups) reflects their genetic and phenotypic distinctiveness and will lead to a better understanding of these two groups of microbes (Margos et al. (2016) There is inadequate evidence to support the division of the genus Borrelia. Int. J. Syst. Evol. Microbiol. doi: 10.1099/ijsem.0.001717). ( 28141502 )
2017
25
Serological detection of Tick-Borne Relapsing Fever in Texan domestic dogs. ( 29232415 )
2017
26
Diagnosis of Louse-Borne Relapsing Fever despite Negative Microscopy in Two Asylum Seekers from Eastern Africa. ( 29016302 )
2017
27
Development and optimization of an inA vitro cultivation protocol allows for isolation of Borrelia miyamotoi from patients with hard tick-borne relapsing fever. ( 28110053 )
2017
28
Host Immune Evasion by Lyme and Relapsing Fever Borreliae: Findings to Lead Future Studies for Borrelia miyamotoi. ( 28154563 )
2017
29
Louse-borne relapsing fever in Finland in two asylum seekers from Somalia. ( 27859692 )
2017
30
A relapsing fever group Borrelia sp. is widely distributed among wild deer in Japan. ( 29329785 )
2017
31
Epidemiological study of relapsing fever borreliae detected in Haemaphysalis ticks and wild animals in the western part of Japan. ( 28362864 )
2017
32
Crystal Structure of Borrelia turicatae protein, BTA121, a differentially regulated A gene in the tick-mammalian transmission cycle of relapsing fever spirochetes. ( 29127407 )
2017
33
Relapsing fever in young refugees from East Africa. ( 28774320 )
2017
34
Plasmodium falciparum malaria co-infection with tick-borne relapsing fever in Dakar. ( 28077149 )
2017
35
Relapsing Fever ( 28722942 )
2017
36
Identification and characterization of a histamine-binding lipocalin-like molecule from the relapsing fever tick Ornithodoros turicata. ( 29164729 )
2017
37
Louse-borne relapsing fever in a refugee from Mali. ( 28161771 )
2017
38
Transmission of Borrelia miyamotoi sensu lato relapsing fever group spirochetes in relation to duration of attachment by Ixodes scapularis nymphs. ( 28501504 )
2017
39
Detection of relapsing fever Borrelia spp., Bartonella spp. and Anaplasmataceae bacteria in argasid ticks in Algeria. ( 29145396 )
2017
40
Louse-Borne Relapsing Fever (Borrelia recurrentis) in a Somali Refugee Arriving in Italy: A Re-emerging Infection in Europe? ( 27149282 )
2016
41
Regarding Tick-Borne Relapsing Fever in the Americas; Some Historical Aspects of a Forgotten Disease in Colombia. ( 29056741 )
2016
42
Molecular identification of Borrelia genus in questing hard ticks from Portugal: Phylogenetic characterization of two novel Relapsing Fever-like Borrelia sp. ( 26976475 )
2016
43
Louseborne Relapsing Fever among East African Refugees, Italy, 2015. ( 26812354 )
2016
44
Detection and Characterization of the Emerging Relapsing Fever Pathogen, Borrelia miyamotoi, from the Ixodes ricinus Tick in the Rural Trakya (Thrace) Region of Northwestern Turkey. ( 27788060 )
2016
45
Tick-Borne Relapsing Fever in Dogs. ( 27353196 )
2016
46
Where Are the Ticks? Solving the Mystery of a Tickborne Relapsing Fever Outbreak at a Youth Camp. ( 27188066 )
2016
47
Tick-Borne Relapsing Fever, Southern Spain, 2004-2015. ( 27442975 )
2016
48
Relapsing fever in asylum seekers from Somalia arriving in Belgium in August 2015. ( 27112219 )
2016
49
Correction: Expression of the Tick-Associated Vtp Protein of Borrelia hermsii in a Murine Model of Relapsing Fever. ( 27074024 )
2016
50
Tick-Borne Relapsing Fever Spirochetes in the Americas. ( 28959690 )
2016

Variations for Relapsing Fever

Expression for Relapsing Fever

Search GEO for disease gene expression data for Relapsing Fever.

Pathways for Relapsing Fever

GO Terms for Relapsing Fever

Biological processes related to Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 CRP MEFV TNF TNFRSF1A
2 negative regulation of inflammatory response GO:0050728 9.5 MEFV MVK TNFRSF1A
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.46 TNF TNFRSF1A
4 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.43 TNF TNFRSF1A
5 regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 9.4 TNF TNFRSF1A
6 negative regulation of lipid storage GO:0010888 9.26 CRP TNF
7 positive regulation of ceramide biosynthetic process GO:2000304 9.16 TNF TNFRSF1A
8 death-inducing signaling complex assembly GO:0071550 8.96 TNF TNFRSF1A
9 regulation of establishment of endothelial barrier GO:1903140 8.62 TNF TNFRSF1A

Molecular functions related to Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 ARSI CFH CLPX CRP MEFV MVK

Sources for Relapsing Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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