MCID: RMS001
MIFTS: 42

Rem Sleep Behavior Disorder

Categories: Mental diseases

Aliases & Classifications for Rem Sleep Behavior Disorder

MalaCards integrated aliases for Rem Sleep Behavior Disorder:

Name: Rem Sleep Behavior Disorder 12 55 44 15 73
Rapid Eye Movement Sleep Behavior Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9091
ICD10 33 G47.52
ICD9CM 35 327.42
MeSH 44 D020187
SNOMED-CT 68 415238003
UMLS 73 C0751772

Summaries for Rem Sleep Behavior Disorder

Disease Ontology : 12 A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.

MalaCards based summary : Rem Sleep Behavior Disorder, also known as rapid eye movement sleep behavior disorder, is related to machado-joseph disease and synucleinopathy. An important gene associated with Rem Sleep Behavior Disorder is SNCA (Synuclein Alpha), and among its related pathways/superpathways are Neuroscience and Monoamine Transport. The drugs Suvorexant and Mianserin have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and heart, and related phenotype is behavior/neurological.

Wikipedia : 76 Rapid eye movement sleep behavior disorder (RBD) is a sleep disorder (more specifically a parasomnia) in... more...

Related Diseases for Rem Sleep Behavior Disorder

Diseases related to Rem Sleep Behavior Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 machado-joseph disease 32.0 RPS27A SLC6A3 SNCA
2 synucleinopathy 30.5 LRRK2 SLC6A3 SNCA
3 multiple system atrophy 1 30.5 LRRK2 SLC6A3 SNCA
4 dementia, lewy body 30.4 ACHE LRRK2 RPS27A SLC6A3 SNCA
5 pure autonomic failure 30.3 ACHE SNCA
6 corticobasal degeneration 30.1 LRRK2 RPS27A
7 dementia 30.0 ACHE LRRK2 SLC6A3 SNCA
8 tremor 30.0 LRRK2 SNCA
9 essential tremor 29.9 LRRK2 SLC6A3 SNCA
10 movement disease 29.9 LRRK2 SLC6A3 SNCA
11 restless legs syndrome 29.6 HCRT SLC6A3 SNCA
12 frontotemporal dementia 28.7 ACHE LRRK2 RPS27A SNCA
13 supranuclear palsy, progressive, 1 28.3 ACHE LRRK2 RPS27A SLC6A3 SNCA
14 parkinson disease, late-onset 28.0 ACHE HCRT LRRK2 RPS27A SLC6A3 SNCA
15 hereditary late-onset parkinson disease 10.5 LRRK2 SNCA
16 parkinson disease 10 10.5 LRRK2 SNCA
17 parkinson disease 2, autosomal recessive juvenile 10.5 LRRK2 SNCA
18 parkinson disease 3, autosomal dominant 10.4 LRRK2 SNCA
19 narcolepsy 10.4
20 postencephalitic parkinson disease 10.4 LRRK2 SNCA
21 sleep apnea 10.4
22 apnea, obstructive sleep 10.4
23 early-onset parkinson's disease 10.3 LRRK2 SNCA
24 striatonigral degeneration 10.3 SLC6A3 SNCA
25 depression 10.3
26 alzheimer disease 10.3
27 von economo's disease 10.3 HCRT SNCA
28 sleep disorder 10.2
29 multiple sclerosis 10.2
30 classic progressive supranuclear palsy syndrome 10.2
31 cocaine abuse 10.1 SLC6A3 SNCA
32 leukoencephalopathy, hereditary diffuse, with spheroids 10.1 RPS27A SNCA
33 neuronal intranuclear inclusion disease 10.1 RPS27A SNCA
34 rheumatoid arthritis 10.1
35 arthritis 10.1
36 autonomic dysfunction 10.1
37 niemann-pick disease, type c1 10.0 HCRT SNCA
38 kleine-levin hibernation syndrome 10.0 HCRT SLC6A3
39 aphasia 10.0 LRRK2 SNCA
40 obsessive-compulsive disorder 9.9
41 leukodystrophy, demyelinating, adult-onset, autosomal dominant 9.9
42 aging 9.9
43 alexithymia 9.9
44 leukodystrophy 9.9
45 impulse control disorder 9.9
46 melanoma 9.9
47 cerebritis 9.9
48 pancreatitis 9.9
49 neuronitis 9.9
50 periodic limb movement disorder 9.9

Graphical network of the top 20 diseases related to Rem Sleep Behavior Disorder:



Diseases related to Rem Sleep Behavior Disorder

Symptoms & Phenotypes for Rem Sleep Behavior Disorder

MGI Mouse Phenotypes related to Rem Sleep Behavior Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.17 ACHE ATG4C HCRT LRRK2 MC1R SLC6A3

Drugs & Therapeutics for Rem Sleep Behavior Disorder

Drugs for Rem Sleep Behavior Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Suvorexant Approved, Investigational Phase 4 1030377-33-3
2
Mianserin Approved, Investigational Phase 4 24219-97-4 4184
3
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
4
Iodine Approved, Investigational Phase 4 7553-56-2 807
5
Melatonin Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Not Applicable 73-31-4 896
6 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
7 Antioxidants Phase 4,Phase 2,Not Applicable
8 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
9 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
10 Pharmaceutical Solutions Phase 4,Phase 2
11
Histamine Phosphate Phase 4 51-74-1 65513
12 Adrenergic Agents Phase 4
13 Adrenergic alpha-Antagonists Phase 4
14 Adrenergic Antagonists Phase 4
15 Serotonin Agents Phase 4
16 Serotonin Antagonists Phase 4
17 Histamine Antagonists Phase 4
18 Histamine H1 Antagonists Phase 4
19 Antidepressive Agents Phase 4
20 Antidepressive Agents, Second-Generation Phase 4
21 Psychotropic Drugs Phase 4
22 cadexomer iodine Phase 4
23
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
24 Calamus Nutraceutical Phase 4
25
Rivastigmine Approved, Investigational Phase 3 123441-03-2 77991
26
Acetylcholine Approved Phase 3 51-84-3 187
27
Caffeine Approved, Nutraceutical Phase 3 58-08-2 2519
28 Central Nervous System Stimulants Phase 3
29 Cholinergic Agents Phase 3
30 Cholinesterase Inhibitors Phase 3
31 Neuroprotective Agents Phase 3
32 Phosphodiesterase Inhibitors Phase 3
33 Purinergic P1 Receptor Antagonists Phase 3
34
Sodium oxybate Approved Phase 2 502-85-2 5360545
35
Clonazepam Approved, Illicit Phase 2,Not Applicable 1622-61-3 2802
36
Ethanol Approved Phase 2 64-17-5 702
37 Strawberry Approved, Nutraceutical Phase 2
38 Adjuvants, Anesthesia Phase 2
39 Anesthetics Phase 2
40 Anesthetics, General Phase 2
41 Anesthetics, Intravenous Phase 2
42 GABA Agents Phase 2,Not Applicable
43 GABA Modulators Phase 2,Not Applicable
44 Anticonvulsants Phase 2,Not Applicable
45 Anti-Anxiety Agents Phase 2
46 Anti-Inflammatory Agents Phase 2
47 Antipsychotic Agents Phase 2
48
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
49
Menthol Approved Not Applicable 2216-51-5 16666
50
Levodopa Approved 59-92-7 6047

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease Unknown status NCT02768077 Phase 4 Melatonin(Circadin®);Placebo
2 Study to Determine Whether Ramelteon Helps People With REM Sleep Behavior Disorder Completed NCT01401413 Phase 4 ramelteon;placebo
3 Effect of Slow-release Melatonin (Circadin®) Therapy on Idiopathic RBD: a Pilot Study Recruiting NCT02836743 Phase 4 Circadin;Placebo
4 A Pilot Study of Suvorexant for Insomnia in Parkinson Disease Recruiting NCT02729714 Phase 4 Suvorexant;Placebo
5 Treatment of Sleep Disturbances in Trauma-affected Refugees Active, not recruiting NCT02761161 Phase 4 Mianserin
6 DaTSCAN Imaging in Aging and Neurodegenerative Disease Enrolling by invitation NCT01453127 Phase 4 I-123 Ioflupane solution injection prior to SPECT scan (DaTscan)
7 Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease Enrolling by invitation NCT03258294 Phase 4 Melatonin(Circadin®);Placebo Oral Tablet
8 Study of Rivastigmine to Treat Parkinsonian Apathy Without Dementia Completed NCT00767091 Phase 3 rivastigmine;placebo
9 Caffeine as a Therapy for Parkinson's Disease Completed NCT01738178 Phase 3 Caffeine;Placebo
10 Study of the Symptomatic Effects of Nocturnal Sodium Oxybate in Parkinson's Disease Unknown status NCT02111122 Phase 2 Sodium Oxybate
11 Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism Completed NCT02312908 Phase 2 Clonazepam;Placebo
12 A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease Recruiting NCT02818777 Phase 2 cannabidiol;placebo
13 Identification of a Biomarker Predictive of Evolution of Parkinson Disease Recruiting NCT03230526 Phase 2 [18F]DPA-714 PET scan
14 Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD) Active, not recruiting NCT02708186 Phase 2 Nelotanserin;Placebo
15 Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder Enrolling by invitation NCT02871427 Phase 2 Nelotanserin
16 Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson Disease Not yet recruiting NCT02789592 Phase 2 Melatonin PR;Clonazepam;Melatonin PR placebo;Clonazepam placebo
17 A Study of Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson's Disease Not yet recruiting NCT03582137 Phase 2 Cannabidiol
18 Understanding the Natural History of REM Sleep Behavior Disorder Unknown status NCT01674998
19 Gait and REM Sleep Behavior Disorder Unknown status NCT02554331 Not Applicable
20 Exploring the Relationship Between Alpha-synucleinopathy Related Non-motor Symptom and Post-op. Delirium in Elderly Patients With Spine Surgery Unknown status NCT02550626
21 Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep Behavior Disorder Completed NCT02824341 Not Applicable
22 Brain Imaging in the Idiopathic REM Sleep Behavior Disorder (ALICE) Completed NCT03072940
23 MRI Study of Brain Activity in Healthy Adults and Individuals With Parkinsonism and Rapid Eye Movement Disorder. Completed NCT01547481
24 Cognitive Benefits of Treating Sleep Apnea in Parkinson's Disease Completed NCT00492115 Not Applicable
25 Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder Recruiting NCT03425214 Not Applicable
26 Detecting Parkinson's Disease Through Speech Analysis Recruiting NCT03133611 Not Applicable
27 Efficacy and Safety of Melatonin and Clonazepam for IRBD: Cross-over Study Recruiting NCT03255642 Not Applicable Melatonin 2mg;ClonazePAM 0.5 MG
28 Exploration of the Mechanism of Movement Improvement During RBD in Parkinson's Disease Using NIRS Recruiting NCT03060239 Not Applicable
29 RBD Longitudinal as Prognostic for PD Recruiting NCT00817726
30 Ultra High Field Magnetic Resonance Imaging as a Biomarker for Premotor Parkinson's Disease Recruiting NCT03288909
31 Striatal Dopamine Transmission in Individuals With Isolated Rapid Eye Movement Sleep With Atonia: a Search for Precursor Biomarker for Neurodegeneration Recruiting NCT03353207
32 Investigation of Clinical Feature and Brain Function in Narcoleptic Patients Recruiting NCT03376568
33 Natural History Study of Synucleinopathies Recruiting NCT01799915
34 Subcortical Oscillations in Human Sleep Dysregulation Recruiting NCT03377569
35 Sleep Structure in Refugees Diagnosed With PTSD Recruiting NCT03535636
36 Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease Recruiting NCT02640339
37 Cohort Study to Identify Predictor Factors of Onset and Progression of Parkinson's Disease Recruiting NCT02305147
38 Cognition and Obstructive Sleep Apnea in Parkinson's Disease, Effect of Positive Airway Pressure Therapy Recruiting NCT02209363 Not Applicable
39 Identification of Predictors for Early Cognitive Decline in Men Recruiting NCT03290040
40 Temporal Relationship Between Motor Fluctuations and Nonmotor Fluctuations Recruiting NCT02060695
41 Sporadic Degenerative Ataxia With Adult Onset: Natural History Study Recruiting NCT02701036
42 Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder Active, not recruiting NCT02984137 Not Applicable
43 SudoScan as a Biomarker of Parkinson's Disease Active, not recruiting NCT02767037 Not Applicable
44 Biomarkers of Risk of Parkinson Disease Active, not recruiting NCT00775853
45 Evolution of RBD in PD Not yet recruiting NCT03047408 Not Applicable
46 Sleep Disturbances and Biomarkers of Sarcopenic OBesity Not yet recruiting NCT03175601
47 Efficacy and Tolerability of Ramelteon in Patients With Rapid Eye Movement (REM) Behavior Disorder and Parkinsonism Terminated NCT00745030 Not Applicable Rozerem;Placebo
48 Motor Control During Rapid Eye Movement (REM) Sleep Behaviour Disorder Terminated NCT01886131 Not Applicable

Search NIH Clinical Center for Rem Sleep Behavior Disorder

Cochrane evidence based reviews: rem sleep behavior disorder

Genetic Tests for Rem Sleep Behavior Disorder

Anatomical Context for Rem Sleep Behavior Disorder

MalaCards organs/tissues related to Rem Sleep Behavior Disorder:

41
Eye, Brain, Heart, Testes, Pons, Colon, Skin

Publications for Rem Sleep Behavior Disorder

Articles related to Rem Sleep Behavior Disorder:

(show top 50) (show all 419)
# Title Authors Year
1
Glucocerebrosidase gene variants are accumulated in idiopathic REM sleep behavior disorder. ( 29487000 )
2018
2
The clinical relevance of cognitive impairment in REM sleep behavior disorder. ( 29669910 )
2018
3
LRRK2 protective haplotype and full sequencing study in REM sleep behavior disorder. ( 29576439 )
2018
4
Predicting alpha-synuclein pathology by REM sleep behavior disorder diagnosis. ( 29779682 )
2018
5
REM sleep behavior disorder portends poor prognosis in Parkinson's disease: A systematic review. ( 29102236 )
2018
6
Presynaptic dopaminergic neuroimaging in REM sleep behavior disorder: A systematic review and meta-analysis. ( 29784534 )
2018
7
Longstanding disease-free survival in idiopathic REM sleep behavior disorder: Is neurodegeneration inevitable? ( 29724601 )
2018
8
REM Sleep Behavior Disorder and Alzheimer's Disease: Definitely No Relationship? ( 29578489 )
2018
9
Insights Into Polysomnography-Confirmed REM Sleep Behavior Disorder From New Prevalence and Gender Data in the General Population. ( 29390088 )
2018
10
Cortical and subcortical gray matter bases of cognitive deficits in REM sleep behavior disorder. ( 29669906 )
2018
11
Risk variants of the I+-synuclein locus and REM sleep behavior disorder in Parkinson's disease: a genetic association study. ( 29466944 )
2018
12
Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder. ( 29402935 )
2018
13
Microstructural changes in patients with Parkinson disease and REM sleep behavior disorder: depressive symptoms versus non-depressed. ( 29442234 )
2018
14
The metabolic pattern of idiopathic REM sleep behavior disorder reflects early-stage Parkinson's disease. ( 29476004 )
2018
15
Observations on muscle activity in REM sleep behavior disorder assessed with a semi-automated scoring algorithm. ( 29353182 )
2018
16
Prospective memory in idiopathic REM sleep behavior disorder with or without mild cognitive impairment: a preliminary study. ( 29411691 )
2018
17
The prospective memory of patients with idiopathic REM sleep behavior disorder. ( 29880143 )
2018
18
Screening for idiopathic REM sleep behavior disorder: usefulness of actigraphy. ( 29554362 )
2018
19
How does dementia with Lewy bodies start? prodromal cognitive changes in REM sleep behavior disorder. ( 29665124 )
2018
20
REM Sleep Behavior Disorder. ( 29145189 )
2018
21
The REM sleep circuit and how its impairment leads to REM sleep behavior disorder. ( 29846796 )
2018
22
Idiopathic REM sleep behavior disorder in the elderly Spanish community: a primary care center study with a two-stage design using video-polysomnography. ( 29042180 )
2017
23
FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder. ( 28734065 )
2017
24
Excessive Daytime Sleepiness Does Not Predict Neurodegeneration in Idiopathic REM Sleep Behavior Disorder. ( 29294136 )
2017
25
Differences in clinical characteristics when REM sleep behavior disorder precedes or comes after the onset of Parkinson's disease. ( 29111021 )
2017
26
REM Sleep Behavior Disorder and Cognitive Impairment in Parkinson's Disease. ( 28645156 )
2017
27
REM sleep behavior disorder, autonomic dysfunction and synuclein-related neurodegeneration: where do we stand? ( 28871332 )
2017
28
Prevalence and Determinants of REM Sleep Behavior Disorder in the General Population. ( 29216391 )
2017
29
SNCA 3'UTR genetic variants in patients with Parkinson's disease and REM sleep behavior disorder. ( 28409245 )
2017
30
Clinical Overview of REM Sleep Behavior Disorder. ( 28837993 )
2017
31
REM sleep behavior disorder is related to enteric neuropathology in Parkinson disease. ( 28887374 )
2017
32
A patient with childhood-onset aggressive parasomnia diagnosed 50 years later with idiopathic REM sleep behavior disorder and a history of sleepwalking. ( 28709007 )
2017
33
REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions. ( 29101940 )
2017
34
Skin nerve phosphorylated I+-synuclein deposits in idiopathic REM sleep behavior disorder. ( 28468843 )
2017
35
REM Sleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies. ( 28513079 )
2017
36
Twenty Years After: Another Case Report of Melatonin Effects on REM Sleep Behavior Disorder, Using Serial Dopamine Transporter Imaging. ( 29860260 )
2017
37
REM Sleep EEG Instability in REM Sleep Behavior Disorder and Clonazepam Effects. ( 28482056 )
2017
38
The REM Sleep Behavior Disorder Screening Questionnaire: Validation Study of the Korean Version (RBDQ-KR). ( 29117888 )
2017
39
Diagnostic REM sleep muscle activity thresholds in patients with idiopathic REM sleep behavior disorder with and without obstructive sleep apnea. ( 28449901 )
2017
40
Epidemiology of REM sleep behavior disorder: both study design and measurement tool count. ( 29129579 )
2017
41
Prospective memory impairment in idiopathic REM sleep behavior disorder. ( 29072553 )
2017
42
The influence of sleep disordered breathing in REM sleep behavior disorder. ( 28673760 )
2017
43
REM sleep behavior disorder and obstructive sleep apnea: does one "evil" make the other less or more "evil"? ( 28754242 )
2017
44
Periodic Limb Movements During Sleep Mimicking REM Sleep Behavior Disorder: A New Form of Periodic Limb Movement Disorder. ( 28364416 )
2017
45
Probable REM-Sleep Behavior Disorder and Dysautonomic Symptoms in Essential Tremor. ( 29520329 )
2017
46
REM Sleep Behavior Disorder Is Not Associated with a More Rapid Cognitive Decline in Mild Dementia. ( 28824532 )
2017
47
Colonic Oxidative and Mitochondrial Function in Parkinson's Disease and Idiopathic REM Sleep Behavior Disorder. ( 28660090 )
2017
48
Characterization of motor events in REM sleep behavior disorder. ( 28721577 )
2017
49
Two polysomnographic features of REM sleep behavior disorder: Clinical variations insight for Parkinson's disease. ( 28923293 )
2017
50
Characterization of patients with longstanding idiopathic REM sleep behavior disorder. ( 28615430 )
2017

Variations for Rem Sleep Behavior Disorder

Expression for Rem Sleep Behavior Disorder

Search GEO for disease gene expression data for Rem Sleep Behavior Disorder.

Pathways for Rem Sleep Behavior Disorder

GO Terms for Rem Sleep Behavior Disorder

Cellular components related to Rem Sleep Behavior Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.67 ACHE HCRT LRRK2 SNCA
2 neuronal cell body GO:0043025 9.61 LRRK2 SLC6A3 SNCA
3 axon GO:0030424 9.58 LRRK2 SLC6A3 SNCA
4 mitochondrial outer membrane GO:0005741 9.5 LRRK2 RPS27A SNCA
5 terminal bouton GO:0043195 9.48 LRRK2 SNCA
6 rough endoplasmic reticulum GO:0005791 9.46 HCRT SNCA
7 synapse GO:0045202 9.46 ACHE HCRT LRRK2 SNCA
8 inclusion body GO:0016234 9.26 LRRK2 SNCA
9 synaptic vesicle GO:0008021 9.13 HCRT LRRK2 SNCA
10 postsynapse GO:0098794 8.8 HCRT LRRK2 SNCA

Biological processes related to Rem Sleep Behavior Disorder according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein phosphorylation GO:0001933 9.49 LRRK2 SNCA
2 negative regulation of neuron death GO:1901215 9.48 LRRK2 SNCA
3 receptor internalization GO:0031623 9.46 ACHE SNCA
4 response to cocaine GO:0042220 9.43 SLC6A3 SNCA
5 regulation of neuron death GO:1901214 9.4 LRRK2 SNCA
6 regulation of neurotransmitter secretion GO:0046928 9.37 HCRT SNCA
7 neurotransmitter biosynthetic process GO:0042136 9.32 ACHE SLC6A3
8 dopamine biosynthetic process GO:0042416 9.26 SLC6A3 SNCA
9 regulation of locomotion GO:0040012 9.16 LRRK2 SNCA
10 dopamine uptake involved in synaptic transmission GO:0051583 8.96 SLC6A3 SNCA
11 excitatory postsynaptic potential GO:0060079 8.8 HCRT LRRK2 SNCA

Sources for Rem Sleep Behavior Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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