MCID: RMS001
MIFTS: 47

Rem Sleep Behavior Disorder

Categories: Eye diseases, Mental diseases

Aliases & Classifications for Rem Sleep Behavior Disorder

MalaCards integrated aliases for Rem Sleep Behavior Disorder:

Name: Rem Sleep Behavior Disorder 12 54 44 15 17 70
Rapid Eye Movement Sleep Behaviour Disorder 12
Rapid Eye Movement Sleep Behavior Disorder 12
Rem Sleep Behaviour Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9091
ICD9CM 34 327.42
MeSH 44 D020187
SNOMED-CT 67 415238003
ICD10 32 G47.52
UMLS 70 C0751772

Summaries for Rem Sleep Behavior Disorder

Disease Ontology : 12 A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.

MalaCards based summary : Rem Sleep Behavior Disorder, also known as rapid eye movement sleep behaviour disorder, is related to machado-joseph disease and mild cognitive impairment. An important gene associated with Rem Sleep Behavior Disorder is SNCA (Synuclein Alpha), and among its related pathways/superpathways are Pathways of neurodegeneration - multiple diseases and Circadian entrainment. The drugs Sodium oxybate and Iodine have been mentioned in the context of this disorder. Affiliated tissues include eye, cortex and subthalamic nucleus, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 73 Rapid eye movement sleep behavior disorder or REM behavior disorder (RBD) is a sleep disorder (more... more...

Related Diseases for Rem Sleep Behavior Disorder

Diseases related to Rem Sleep Behavior Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 210)
# Related Disease Score Top Affiliating Genes
1 machado-joseph disease 31.6 SNCA SLC6A3 RPS27A PRKN APOE
2 mild cognitive impairment 31.1 MAPT BCHE APOE
3 parkinsonism 30.9 SNCA SLC6A3 PINK1 MAPT LRRK2 GBA
4 tremor 30.8 SNCA PRKN LRRK2 GBA
5 apnea, obstructive sleep 30.8 IGLON5 HCRT APOE
6 corticobasal degeneration 30.7 RPS27A MAPT GBA
7 multiple system atrophy 1 30.5 SNCA SLC6A3 RPS27A PRKN MAPT LRRK2
8 subjective cognitive decline 30.3 MAPT APOE
9 posterior cortical atrophy 30.3 MAPT APOE
10 speech disorder 30.3 SLC6A3 MAPT GBA
11 apraxia 30.3 SLC6A3 MAPT APOE
12 binswanger's disease 30.2 MAPT APOE ACHE
13 frontotemporal lobar degeneration with tdp43 inclusions, grn-related 30.2 RPS27A MAPT
14 olivopontocerebellar atrophy 30.1 SNCA SLC6A3 RPS27A MAPT
15 aphasia 30.1 SNCA MAPT LRRK2 APOE
16 anxiety 30.0 SNCA SLC6A3 HCRT APOE ACHE
17 restless legs syndrome 30.0 SNCA SLC6A3 PRKN MAPT HCRT
18 amnestic disorder 30.0 MAPT BCHE APOE ACHE
19 neurodegeneration with brain iron accumulation 29.8 SNCA PRKN PINK1
20 vascular dementia 29.8 MAPT BCHE APOE ACHE
21 major depressive disorder 29.8 SLC6A3 PER2 NR1D1 HCRT ARNTL APOE
22 parkinson disease 10 29.7 SNCA PRKN PINK1 LRRK2
23 essential tremor 29.7 SNCA SLC6A3 PRKN MAPT LRRK2 GBA
24 dementia, lewy body 29.7 SNCA SLC6A3 RPS27A PRKN PINK1 MAPT
25 sleep disorder 29.6 SNCA SLC6A3 PER2 NR1D1 MAPT LRRK2
26 dystonia 29.5 SLC6A3 PRKN PINK1 LRRK2 HCRT APOE
27 attention deficit-hyperactivity disorder 29.2 SNCA SLC6A3 PRKN PER2 BCHE ARNTL
28 motor neuron disease 29.2 SNCA RPS27A PRKN MAPT APOE
29 movement disease 29.1 SNCA SLC6A3 PRKN PINK1 MAPT LRRK2
30 frontotemporal dementia 29.1 SNCA RPS27A MAPT LRRK2 HCRT BCHE
31 dementia 29.1 SNCA SLC6A3 PRKN PINK1 MAPT LRRK2
32 autosomal dominant cerebellar ataxia 28.9 SNCA RPS27A PRKN PINK1 MAPT LRRK2
33 parkinson disease, late-onset 28.7 SNCA SLC6A3 RPS27A PRKN PINK1 MAPT
34 amyotrophic lateral sclerosis 1 28.5 SNCA SLC6A3 RPS27A PRKN PINK1 MAPT
35 alzheimer disease 28.4 SNCA RPS27A PRKN PINK1 MAPT LRRK2
36 supranuclear palsy, progressive, 1 27.8 SNCA SLC6A3 RPS27A PRKN PINK1 MAPT
37 sleep apnea 10.9
38 narcolepsy 10.9
39 autonomic dysfunction 10.7
40 constipation 10.7
41 pure autonomic failure 10.7
42 post-traumatic stress disorder 10.5
43 head injury 10.5
44 acute stress disorder 10.5
45 huntington disease 10.4
46 periodic limb movement disorder 10.4
47 hypersomnia 10.4
48 impulse control disorder 10.4
49 bruxism 10.4
50 insulinoma 10.4

Graphical network of the top 20 diseases related to Rem Sleep Behavior Disorder:



Diseases related to Rem Sleep Behavior Disorder

Symptoms & Phenotypes for Rem Sleep Behavior Disorder

MGI Mouse Phenotypes related to Rem Sleep Behavior Disorder:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.42 ACHE APOE ARNTL GBA HCRT LRRK2
2 homeostasis/metabolism MP:0005376 10.38 ACHE APOE ARNTL BCHE GBA HCRT
3 growth/size/body region MP:0005378 10.36 ACHE APOE ARNTL GBA HCRT MAPT
4 cellular MP:0005384 10.34 APOE ARNTL GBA LRRK2 MAPT MC1R
5 hematopoietic system MP:0005397 10.34 ACHE APOE ARNTL BST1 GBA LRRK2
6 cardiovascular system MP:0005385 10.28 ACHE APOE ARNTL GBA HCRT LRRK2
7 mortality/aging MP:0010768 10.25 ACHE APOE ARNTL BCHE GBA LRRK2
8 immune system MP:0005387 10.23 APOE ARNTL BST1 GBA IGLON5 LRRK2
9 nervous system MP:0003631 10.17 ACHE APOE ARNTL GBA HCRT LRRK2
10 integument MP:0010771 10.13 APOE ARNTL GBA LRRK2 MAPT MC1R
11 muscle MP:0005369 9.97 ACHE APOE ARNTL HCRT MAPT NR1D1
12 no phenotypic analysis MP:0003012 9.96 ACHE APOE LRRK2 MAPT MC1R NR1D1
13 skeleton MP:0005390 9.7 APOE ARNTL GBA LRRK2 NR1D1 PER1
14 pigmentation MP:0001186 9.55 APOE GBA LRRK2 MC1R PER2
15 taste/olfaction MP:0005394 9.02 APOE MAPT PINK1 SLC6A3 SNCA

Drugs & Therapeutics for Rem Sleep Behavior Disorder

Drugs for Rem Sleep Behavior Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium oxybate Approved Phase 4 502-85-2 5360545
2
Iodine Approved, Investigational Phase 4 7553-56-2 807
3
Cadexomer iodine Experimental Phase 4 94820-09-4
4 Anesthetics Phase 4
5 Anesthetics, General Phase 4
6 Anesthetics, Intravenous Phase 4
7 Pharmaceutical Solutions Phase 4
8 Calamus Phase 4
9
Idebenone Approved, Investigational Phase 2, Phase 3 58186-27-9
10
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 2, Phase 3 303-98-0 5281915
11 Nutrients Phase 2, Phase 3
12 Micronutrients Phase 2, Phase 3
13 Trace Elements Phase 2, Phase 3
14 Vitamins Phase 2, Phase 3
15 Ubiquinone Phase 2, Phase 3
16
Clonazepam Approved, Illicit Phase 2 1622-61-3 2802
17
Terazosin Approved Phase 2 63590-64-7 5401
18
Iron Approved Phase 1, Phase 2 7439-89-6 23925 29936
19
Penciclovir Approved Phase 1, Phase 2 39809-25-1 4725
20
Carvedilol Approved, Investigational Phase 2 72956-09-3 2585
21 Orange Approved Phase 2
22
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 11103-57-4 445354
23 GABA Modulators Phase 2
24 Anticonvulsants Phase 2
25 retinol Phase 2
26 Retinol palmitate Phase 2
27 Protective Agents Phase 2
28 Antioxidants Phase 2
29 Neurotransmitter Agents Phase 2
30 Adrenergic alpha-1 Receptor Antagonists Phase 2
31 Vasodilator Agents Phase 2
32 Adrenergic alpha-Antagonists Phase 2
33 Adrenergic Antagonists Phase 2
34 Adrenergic Agents Phase 2
35 Antihypertensive Agents Phase 2
36 Adrenergic beta-Antagonists Phase 2
37 Hormones Phase 2
38 calcium channel blockers Phase 2
39 Calcium, Dietary Phase 2
40
Calcium Nutraceutical Phase 2 7440-70-2 271
41
Dopamine Approved 62-31-7, 51-61-6 681
42
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
43 Dopamine agonists
44 Antiparkinson Agents
45 Cholinergic Agents
46 Narcotics
47 Cola
48 Antidepressive Agents

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Effect of Slow-release Melatonin (Circadin®) Therapy on Idiopathic REM Sleep Behavior Disorder: a Pilot Study Unknown status NCT02836743 Phase 4 Circadin;Placebo
2 A Prospective Randomized, Placebo-Controlled Double-Blind Study to Determine the Efficacy of Ramelteon in REM Sleep Behavior Disorder Completed NCT01401413 Phase 4 ramelteon;placebo
3 Sodium Oxybate in Treatment-Resistant REM Sleep Behavior Disorder (RBD): A Randomized Placebo-Controlled Trial Recruiting NCT04006925 Phase 4 Sodium Oxybate
4 DaTSCAN Imaging in Aging and Neurodegenerative Disease Enrolling by invitation NCT01453127 Phase 4 I-123 Ioflupane solution injection prior to SPECT scan (DaTscan)
5 A Study of Efficacy and Safety of Idebenone vs. Placebo in Prodromal Parkinson Disease (SEASEiPPD) Recruiting NCT04152655 Phase 2, Phase 3 Idebenone;Placebo oral tablet
6 A Randomized Double-Blind, Double-Dummy, Crossover Study to Evaluate the Efficacy and Safety of Prolonged-Release Melatonin and Clonazepam in Patients With Rapid Eye Movement (REM) Sleep Behavior Disorder in Parkinson Disease Unknown status NCT02789592 Phase 2 Melatonin PR;Clonazepam;Melatonin PR placebo;Clonazepam placebo
7 Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism: a Prospective, Randomized, Double-blind and Placebo-controlled Trial Completed NCT02312908 Phase 2 Clonazepam;Placebo
8 A Phase 2, Double-blind, Randomized, Placebo-controlled Study of Nelotanserin Versus Placebo in Subjects With Dementia With Lewy Bodies (DLB) or Parkinson's Disease Dementia (PDD) Who Have REM Sleep Behavior Disorder (RBD) Completed NCT02708186 Phase 2 Nelotanserin;Placebo
9 The Effect of Adrenergic Blocker Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease Recruiting NCT03775096 Phase 2 Carvedilol
10 The Effect of a1- Adrenergic Receptor Antagonist Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease Recruiting NCT04386317 Phase 2 Terazosin
11 Quantitative Mapping of Substantia Nigra Iron in Parkinson's Disease and Controls Recruiting NCT03675282 Phase 1, Phase 2 (11C)PE2I
12 The Effect of Adrenergic Blocker Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease: A Follow up Study Enrolling by invitation NCT04218968 Phase 2 Carvedilol
13 A Phase II, Randomized, Placebo-Controlled, Double-Blind, Crossover, Study of the Pharmacodynamic Effects of CST-103 Co-administered With CST-107 on the Central Nervous System in Subjects With Neurodegenerative Disorders Not yet recruiting NCT04739423 Phase 2 CST-103, CST-107, matching placebo
14 A Randomized, Double-blind, Multi-center Clinical Study of the Efficacy of Idebenone in the Treatment of Primary Rapid Eye Movement Sleep Behavior Disorder Into Synucleinopathies Not yet recruiting NCT04534023 Phase 2 Idebenone;Placebo
15 An Open-label Study of Nelotanserin in Patients With Lewy Body Dementia Who Have Frequent Visual Hallucinations or REM Sleep Behavior Disorder Terminated NCT02871427 Phase 2 Nelotanserin
16 Familial Aggregation and Biomarkers in REM Sleep Behaviour Disorder: a Case-control Family Study Unknown status NCT03660982
17 Evolution of REM Sleep Behavior Disorder in Parkinson's Disease Patients RBD Diagnosed Three Years Earlier Unknown status NCT03047408
18 Understanding Autonomic Function in REM Sleep Behavior Disorder, Parkinsonism and Controls Unknown status NCT01674998
19 Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder Unknown status NCT03425214
20 Feature of Polysomnography and Cerebral Metabolism and Function in Narcolepsy With/Without RBD and Control Subject Unknown status NCT03376568
21 Exploration of the Mechanism of Movement Improvement During Rapid Eye Movement (REM) Sleep Behaviour Disorder (RBD) in Parkinson's Disease Using Near-infrared Spectroscopy (NIRS) Completed NCT03060239
22 Striatal Dopamine Transmission in Individuals With Isolated Rapid Eye Movement Sleep With Atonia: a Search for Precursor Biomarker for Neurodegeneration Completed NCT03353207
23 3 T Multimodal MRI in Idiopathic RBD Completed NCT03072940
24 Efficacy and Safety of Melatonin and Rivotril Treatment for Idiopathic Rapid Eye Movement Sleep Disorder: Prospective Randomized Study. Completed NCT03255642 Melatonin 2mg;ClonazePAM 0.5 MG
25 Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep Behavior Disorder Completed NCT02824341
26 A Prospective Longitudinal Neuroimaging and Biomarker Cohort Study in Idiopathic Rapid Eye Movement(REM) Sleep Behavior Disorder Completed NCT02984137
27 Recherche et Mesure d'Anomalies précoces de la Marche au Cours Des Troubles du Comportement en Sommeil Paradoxal Idiopathiques Completed NCT02554331
28 Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease Completed NCT02640339
29 Statistical Mapping of the Brain in Progressive Supranuclear Palsy, Essential Tremor, Parkinson Disease, Parkinsonism, and REM Behavior Disorder Completed NCT01547481
30 A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies Recruiting NCT04020198
31 Visualising the Cerebral Cholinergic Innervation and Parasympathetic Gastrointestinal Nerves in Patients With Dementia Lewy Bodies. Recruiting NCT04291144
32 Prodromal Markers of α-synucleinopathy Neurodegeneration in the First-degree Relatives of Patients With Psychiatric Disorders Comorbid With REM Sleep Behavior Disorder Recruiting NCT03595475
33 North American Prodromal Synucleinopathy Consortium Recruiting NCT03623672
34 Gut Microbiota Across Early Stages of Synucleinopathy: From High-risk Relatives, REM Sleep Behavior Disorder to Early Parkinson's Disease Recruiting NCT03645226
35 Establish a National Registry to Search for the Risk Factors, Etiology, and Neurodegenerative Progression of REM Sleep Behavior Disorder Recruiting NCT03671798
36 Progression of Prodromal Markers of α-synucleinopathy Neurodegeneration in the First-degree Relatives of Patients With REM Sleep Behavior Disorder: a 5-year Prospective Study Recruiting NCT03671772
37 French Validation of a Severity Scale in REM Sleep Behavior Disorder Recruiting NCT04071899
38 A 7-year Prospective Study of Idiopathic REM Sleep Behavior Disorder Cohort in Chinese Population: Determining the Optimal Characteristics of Biomarkers to Predict Neurodegenerative Diseases Recruiting NCT04048603
39 Natural History Study of Synucleinopathies Recruiting NCT01799915
40 Understanding the Role of Subcortical Oscillations in Human Sleep Dysregulation. Recruiting NCT03377569
41 Ultra High Field Magnetic Resonance Imaging as a Biomarker for Premotor Parkinson's Disease Recruiting NCT03288909
42 A Natural History Analysis of Rapid Eye Movement Sleep Behavior Disorder as Prognostic for Parkinson's Disease Active, not recruiting NCT00817726
43 Automatic Acoustic Speech Analysis and REM Sleep Behaviour Disorder for Detecting Subjects at High Risk for Parkinson's Disease and Other Alpha-synucleinopathies Active, not recruiting NCT03133611
44 Establishing Alpha-synuclein Real Time - Quaking Induced Conversion (RT-QuIC) Assay as a Diagnostic Technique in REM Sleep Behaviour Disorder (RBD) Not yet recruiting NCT04266457
45 Subthalamic Nuclei (STN) Local Field Potentials to Investigate Motor Control During REM Sleep Behaviour Disorder (TCSP) Secondary to Idiopathic Parkinsons Disease (PD) Terminated NCT01886131
46 Efficacy and Tolerability of Ramelteon in Patients With REM Behavior Disorder and Parkinsonism: A Placebo Controlled, Double Blind, Randomized, Prospective Pilot Study Terminated NCT00745030 Rozerem;Placebo

Search NIH Clinical Center for Rem Sleep Behavior Disorder

Cochrane evidence based reviews: rem sleep behavior disorder

Genetic Tests for Rem Sleep Behavior Disorder

Anatomical Context for Rem Sleep Behavior Disorder

MalaCards organs/tissues related to Rem Sleep Behavior Disorder:

40
Eye, Cortex, Subthalamic Nucleus, Pineal, Spinal Cord, Olfactory Bulb, Thalamus

Publications for Rem Sleep Behavior Disorder

Articles related to Rem Sleep Behavior Disorder:

(show top 50) (show all 1517)
# Title Authors PMID Year
1
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. 61 54
16237129 2005
2
The Arousal Disorders Questionnaire: a new and effective screening tool for confusional arousals, Sleepwalking and Sleep Terrors in epilepsy and sleep disorders units. 61
33610075 2021
3
Proof of concept: Screening for REM sleep behaviour disorder with a minimal set of sensors. 61
33636605 2021
4
REM sleep behaviour disorder in essential tremor: A polysomnographic study. 61
32323893 2021
5
Prevalence and predictors of mood disturbances in idiopathic REM sleep behaviour disorder. 61
32255236 2021
6
Improving estimation of Parkinson's disease risk-the enhanced PREDICT-PD algorithm. 61
33795693 2021
7
Sleep Disorders in Patients with Essential Tremor. 61
33754217 2021
8
Longitudinal Changes in Isolated Rapid Eye Movement Sleep Behavior Disorder-Related Metabolic Pattern Expression. 61
33788284 2021
9
Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study. 61
33609478 2021
10
Monocyte markers correlate with immune and neuronal brain changes in REM sleep behavior disorder. 61
33658371 2021
11
The role of pedunculopontine nucleus in isolated REM sleep behavior disorder and REM sleep without atonia. 61
33571873 2021
12
Risk stratification for REM sleep behavior disorder in patients with Parkinson's disease: A PRISMA-compliant meta-analysis and systematic review. 61
33556851 2021
13
Complications following REM sleep behavior disorder. 61
33784025 2021
14
Association of heart rate variability with REM sleep without atonia in idiopathic REM sleep behavior disorder. 61
33112228 2021
15
Specialist approaches to prognostic counseling in isolated REM sleep behavior disorder. 61
33486257 2021
16
Significance of hyposmia in isolated REM sleep behavior disorder. 61
32968939 2021
17
Melatonin (MEL) and its use in neurological diseases and insomnia: Recommendations of the French Medical and Research Sleep Society (SFRMS). 61
32921425 2021
18
Morbidity, Mortality, and Conversion to Neurodegenerative Diseases in Patients with REM Sleep Behavior Disorder and REM Sleep without Atonia. 61
33780948 2021
19
Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder. 61
33397775 2021
20
Sleep Disorders and Cognitive Dysfunctions in Parkinson's Disease: A Meta-Analytic Study. 61
33779875 2021
21
Is REM sleep behavior disorder a friend or foe of obstructive sleep apnea? Clinical and etiological implications for neurodegeneration. 61
33660615 2021
22
The fate of patients with REM sleep behavior disorder and mild cognitive impairment. 61
32451160 2021
23
Prefrontal network dysfunctions in rapid eye movement sleep behavior disorder. 61
33744693 2021
24
Cannabidiol for Rapid Eye Movement Sleep Behavior Disorder. 61
33754375 2021
25
Limbic hypoconnectivity in idiopathic REM sleep behaviour disorder with impulse control disorders. 61
33709218 2021
26
Towards subgroup-specific risk estimates: A meta-analysis of longitudinal studies on olfactory dysfunction and risk of Parkinson's disease. 61
33487544 2021
27
REM Sleep Behavior Disorder and REM Sleep Without Atonia are More Frequent in Advanced versus Early Parkinson's Disease. 61
33720377 2021
28
Altered insular functional connectivity in isolated REM sleep behavior disorder: a data-driven functional MRI study. 61
33485260 2021
29
Probable REM sleep behavior disorder is associated with longitudinal cortical thinning in Parkinson's disease. 61
33654107 2021
30
Olfactory impairment as an early marker of Parkinson's disease in REM sleep behaviour disorder: a systematic review and meta-analysis. 61
33436502 2021
31
Early diagnosis of prodromal dementia with Lewy bodies using clinical history of probable REM sleep behaviour disorder and cardiac 123 I-MIBG scintigraphy in memory clinics. 61
33565213 2021
32
REM sleep absence in patients referred to polysomnography for REM sleep behavior disorder. 61
33502592 2021
33
Timeline of Rapid Eye Movement Sleep Behavior Disorder in Overt Alpha-Synucleinopathies. 61
33155696 2021
34
Impact of rapid eye movement sleep behavior disorder and autonomic disorders on Parkinson's disease: a review. 61
33759983 2021
35
The Association Between REM Sleep Behavior Disorder and Autonomic Dysfunction in Parkinson's Disease. 61
33579870 2021
36
Health, social, and economic consequences of rapid eye movement sleep behavior disorder: a controlled national study evaluating societal effects. 61
32844211 2021
37
Premotor Parkinson's disease: Overview of clinical symptoms and current diagnostic methods. 61
33542542 2021
38
microRNA signatures in prodromal REM sleep behavior disorder and early Parkinson's disease as noninvasive biomarkers. 61
33444973 2021
39
Late onset depression: dopaminergic deficit and clinical features of prodromal Parkinson's disease: a cross-sectional study. 61
33268471 2021
40
Dopaminergic imaging and clinical predictors for phenoconversion of REM sleep behaviour disorder. 61
33348363 2021
41
Modifiable Comorbidities Associated with Cognitive Decline in Parkinson's Disease. 61
33553496 2021
42
Sleep Disorders in dogs: A Pathophysiological and Clinical Review. 61
33556640 2021
43
A high-density electroencephalography study reveals abnormal sleep homeostasis in patients with rapid eye movement sleep behavior disorder. 61
33637812 2021
44
Sleep-related head jerks: toward a new movement disorder. 61
32860690 2021
45
Olfactory Testing in Parkinson's Disease & REM Behavior Disorder: A Machine Learning Approach. 61
33627500 2021
46
Nonrapid eye movement sleep electroencephalographic oscillations in idiopathic rapid eye movement sleep behavior disorder: a study of sleep spindles and slow oscillations. 61
32827438 2021
47
A case series and systematic review of rapid eye movement sleep behavior disorder outcome after deep brain stimulation in Parkinson's disease. 61
33412362 2021
48
Quantitative REM Sleep without Atonia in Parkinson's Disease and Essential Tremor. 61
33426157 2021
49
Progression of sleep disturbances in Parkinson's disease: a 5-year longitudinal study. 61
32804280 2021
50
Increased plasma orexin-A concentrations are associated with the non-motor symptoms in Parkinson's disease patients. 61
33161104 2021

Variations for Rem Sleep Behavior Disorder

Expression for Rem Sleep Behavior Disorder

Search GEO for disease gene expression data for Rem Sleep Behavior Disorder.

Pathways for Rem Sleep Behavior Disorder

Pathways related to Rem Sleep Behavior Disorder according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.31 SNCA SLC6A3 RPS27A PRKN PINK1 MAPT
2
Show member pathways
12.62 SLC6A3 PER2 PER1 ARNTL ACHE
3
Show member pathways
12.58 SNCA SLC6A3 RPS27A PRKN PINK1 MAPT
5
Show member pathways
12.05 RPS27A PER2 PER1 NR1D1 ARNTL
6 11.86 SNCA RPS27A PRKN PINK1 NR1D1 MAPT
7 11.54 RPS27A PRKN PINK1
8 11.48 SNCA SLC6A3 PRKN PINK1 LRRK2
9 11.38 PER2 PER1 ARNTL
10
Show member pathways
11.33 RPS27A PRKN PINK1
11
Show member pathways
11.19 PER2 PER1 NR1D1 ARNTL
12 11.16 SNCA SLC6A3 PRKN
13
Show member pathways
11.05 SLC6A3 BCHE ACHE
14 10.92 PER2 PER1 ARNTL APOE ACHE
15 10.69 PER1 NR1D1 ARNTL
16
Show member pathways
10.65 PER1 ARNTL
17 10.64 RPS27A PRKN

GO Terms for Rem Sleep Behavior Disorder

Cellular components related to Rem Sleep Behavior Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.28 SNCA SLC6A3 RPS27A PRKN PINK1 PER2
2 synapse GO:0045202 9.88 SNCA PRKN NR1D1 LRRK2 HCRT ACHE
3 axon GO:0030424 9.77 SNCA SLC6A3 PINK1 MAPT LRRK2
4 neuronal cell body GO:0043025 9.65 SNCA SLC6A3 MAPT LRRK2 APOE
5 mitochondrial outer membrane GO:0005741 9.62 SNCA RPS27A PINK1 LRRK2
6 growth cone GO:0030426 9.26 SNCA PINK1 MAPT LRRK2
7 perinuclear region of cytoplasm GO:0048471 9.17 SNCA PRKN PINK1 PER2 LAMP3 HCRT
8 Lewy body GO:0097413 9.16 PRKN PINK1

Biological processes related to Rem Sleep Behavior Disorder according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10.17 SNCA RPS27A PRKN PER2 PER1 NR1D1
2 negative regulation of gene expression GO:0010629 10.02 PRKN PINK1 MAPT APOE
3 cellular protein metabolic process GO:0044267 9.97 SNCA RPS27A PRKN APOE
4 autophagy GO:0006914 9.92 PRKN PINK1 LRRK2 GBA
5 cellular response to oxidative stress GO:0034599 9.89 SNCA PINK1 LRRK2
6 positive regulation of cold-induced thermogenesis GO:0120162 9.88 PER2 HCRT ACHE
7 negative regulation of protein phosphorylation GO:0001933 9.86 SNCA PRKN LRRK2
8 rhythmic process GO:0048511 9.86 PER2 PER1 NR1D1 ARNTL
9 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 9.85 PRKN LRRK2 GBA
10 response to oxidative stress GO:0006979 9.83 PRKN PINK1 LRRK2 APOE
11 regulation of circadian rhythm GO:0042752 9.82 PER2 PER1 NR1D1
12 excitatory postsynaptic potential GO:0060079 9.81 SNCA LRRK2 HCRT
13 mitochondrion organization GO:0007005 9.78 PRKN PINK1 LRRK2 GBA
14 protein destabilization GO:0031648 9.74 SNCA PRKN NR1D1
15 circadian rhythm GO:0007623 9.73 PER2 PER1 NR1D1 ARNTL
16 negative regulation of autophagosome assembly GO:1902902 9.72 PINK1 LRRK2
17 positive regulation of mitochondrial fission GO:0090141 9.72 PRKN PINK1
18 dopamine metabolic process GO:0042417 9.72 SNCA PRKN
19 proteasomal protein catabolic process GO:0010498 9.72 PRKN NR1D1
20 cellular response to dopamine GO:1903351 9.71 PRKN LRRK2
21 negative regulation of macroautophagy GO:0016242 9.71 PINK1 LRRK2
22 neurotransmitter biosynthetic process GO:0042136 9.71 SLC6A3 ACHE
23 locomotory exploration behavior GO:0035641 9.7 LRRK2 APOE
24 supramolecular fiber organization GO:0097435 9.7 SNCA MAPT
25 regulation of calcium-mediated signaling GO:0050848 9.7 MAPT BST1
26 virion assembly GO:0019068 9.7 RPS27A APOE
27 synaptic transmission, dopaminergic GO:0001963 9.69 SNCA PRKN
28 regulation of protein metabolic process GO:0051246 9.69 GBA APOE
29 amyloid precursor protein metabolic process GO:0042982 9.68 APOE ACHE
30 negative regulation of oxidative stress-induced cell death GO:1903202 9.68 PRKN PINK1
31 dopamine biosynthetic process GO:0042416 9.68 SNCA SLC6A3
32 regulation of mitochondrial fission GO:0090140 9.67 MAPT LRRK2
33 negative regulation of JNK cascade GO:0046329 9.67 PRKN PINK1 PER1
34 regulation of autophagy GO:0010506 9.67 PRKN MAPT LRRK2 LAMP3
35 cellular response to manganese ion GO:0071287 9.66 PRKN LRRK2
36 intracellular distribution of mitochondria GO:0048312 9.66 MAPT LRRK2
37 regulation of dopamine metabolic process GO:0042053 9.65 SLC6A3 PRKN
38 regulation of cellular response to oxidative stress GO:1900407 9.65 PRKN PINK1
39 regulation of locomotion GO:0040012 9.65 SNCA LRRK2
40 negative regulation of neuron apoptotic process GO:0043524 9.65 SNCA PRKN PINK1 GBA APOE
41 regulation of protein targeting to mitochondrion GO:1903214 9.63 PRKN PINK1
42 protein localization to mitochondrion GO:0070585 9.63 PRKN LRRK2
43 regulation of reactive oxygen species metabolic process GO:2000377 9.63 SNCA PRKN PINK1
44 negative regulation of glucocorticoid receptor signaling pathway GO:2000323 9.62 PER1 ARNTL
45 circadian regulation of gene expression GO:0032922 9.62 PER2 PER1 NR1D1 ARNTL
46 positive regulation of histone deacetylase activity GO:1901727 9.61 PINK1 LRRK2
47 positive regulation of mitophagy in response to mitochondrial depolarization GO:0098779 9.61 PRKN PINK1
48 cellular response to toxic substance GO:0097237 9.6 PRKN PINK1
49 regulation of hair cycle GO:0042634 9.59 PER1 ARNTL
50 positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization GO:1904925 9.58 PINK1 GBA

Molecular functions related to Rem Sleep Behavior Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin protein ligase binding GO:0031625 9.72 RPS27A PRKN PINK1 PER1 MC1R
2 amyloid-beta binding GO:0001540 9.63 BCHE APOE ACHE
3 tubulin binding GO:0015631 9.61 PRKN MAPT LRRK2
4 E-box binding GO:0070888 9.54 PER1 NR1D1 ARNTL
5 phospholipase binding GO:0043274 9.48 SNCA PRKN
6 lipoprotein particle binding GO:0071813 9.4 MAPT APOE
7 transcription regulatory region sequence-specific DNA binding GO:0000976 9.35 SNCA PER2 PER1 NR1D1 ARNTL
8 cholinesterase activity GO:0004104 9.26 BCHE ACHE
9 acetylcholinesterase activity GO:0003990 9.16 BCHE ACHE
10 transcription corepressor binding GO:0001222 8.8 PER2 PER1 NR1D1

Sources for Rem Sleep Behavior Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....