MCID: RNL008
MIFTS: 30

Renal Artery Atheroma

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Renal Artery Atheroma

MalaCards integrated aliases for Renal Artery Atheroma:

Name: Renal Artery Atheroma 12 15
Atherosclerosis of Renal Artery 12 73
Renal Atherosclerosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14092
ICD10 33 I70.1
ICD9CM 35 440.1
SNOMED-CT 68 155416004 45281005
UMLS 73 C0155734

Summaries for Renal Artery Atheroma

MalaCards based summary : Renal Artery Atheroma, also known as atherosclerosis of renal artery, is related to tendinopathy and aortic atherosclerosis. An important gene associated with Renal Artery Atheroma is PRKCA (Protein Kinase C Alpha), and among its related pathways/superpathways are Degradation of the extracellular matrix and Diseases of glycosylation. The drugs Clopidogrel and Lercanidipine have been mentioned in the context of this disorder. Related phenotypes are homeostasis/metabolism and muscle

Related Diseases for Renal Artery Atheroma

Graphical network of the top 20 diseases related to Renal Artery Atheroma:



Diseases related to Renal Artery Atheroma

Symptoms & Phenotypes for Renal Artery Atheroma

MGI Mouse Phenotypes related to Renal Artery Atheroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.55 BGN CST3 DCN NOS3 PRKCA
2 muscle MP:0005369 9.35 BGN CST3 DCN NOS3 PRKCA
3 reproductive system MP:0005389 8.92 BGN CST3 DCN NOS3

Drugs & Therapeutics for Renal Artery Atheroma

Drugs for Renal Artery Atheroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
2
Lercanidipine Approved, Investigational Phase 4 100427-26-7 65866
3 calcium channel blockers Phase 4
4 Neurotransmitter Agents Phase 4
5 Antihypertensive Agents Phase 4
6 Platelet Aggregation Inhibitors Phase 4
7 Purinergic P2 Receptor Antagonists Phase 4
8 Purinergic P2Y Receptor Antagonists Phase 4
9 Calcium, Dietary Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Zainidip in Renal Artery Stenosis Completed NCT02594410 Phase 4 Aspirine;Clopidogrel;Lercanidipine

Search NIH Clinical Center for Renal Artery Atheroma

Genetic Tests for Renal Artery Atheroma

Anatomical Context for Renal Artery Atheroma

Publications for Renal Artery Atheroma

Articles related to Renal Artery Atheroma:

# Title Authors Year
1
Atherosclerosis of renal artery and its comparative study with aortic atherosclerosis. ( 5760885 )
1968

Variations for Renal Artery Atheroma

Expression for Renal Artery Atheroma

Search GEO for disease gene expression data for Renal Artery Atheroma.

Pathways for Renal Artery Atheroma

GO Terms for Renal Artery Atheroma

Cellular components related to Renal Artery Atheroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.96 BGN DCN
2 lysosomal lumen GO:0043202 8.62 BGN DCN

Biological processes related to Renal Artery Atheroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.48 NOS3 PRKCA
2 negative regulation of protein kinase activity GO:0006469 9.46 BGN DCN
3 positive regulation of blood vessel endothelial cell migration GO:0043536 9.43 NOS3 PRKCA
4 negative regulation of JAK-STAT cascade GO:0046426 9.4 BGN DCN
5 blood vessel remodeling GO:0001974 9.37 BGN NOS3
6 glycosaminoglycan metabolic process GO:0030203 9.32 BGN DCN
7 chondroitin sulfate biosynthetic process GO:0030206 9.26 BGN DCN
8 chondroitin sulfate catabolic process GO:0030207 9.16 BGN DCN
9 dermatan sulfate biosynthetic process GO:0030208 8.96 BGN DCN
10 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan GO:0019800 8.62 BGN DCN

Molecular functions related to Renal Artery Atheroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase inhibitor activity GO:0004860 9.16 BGN DCN
2 extracellular matrix binding GO:0050840 8.96 BGN DCN
3 glycosaminoglycan binding GO:0005539 8.62 BGN DCN

Sources for Renal Artery Atheroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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