MCID: RNL097
MIFTS: 42

Renal Artery Disease

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Renal Artery Disease

MalaCards integrated aliases for Renal Artery Disease:

Name: Renal Artery Disease 12 15 71
Vascular Disorder of Kidney 12
Renal Vascular Disorder 71
Renal Vascular Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2388
ICD9CM 34 593.81
NCIt 49 C35338
SNOMED-CT 67 16934004
UMLS 71 C0268790 C3640053

Summaries for Renal Artery Disease

MalaCards based summary : Renal Artery Disease, also known as vascular disorder of kidney, is related to arteries, anomalies of and renal artery obstruction. An important gene associated with Renal Artery Disease is REN (Renin), and among its related pathways/superpathways are Development Angiotensin activation of ERK and cGMP-PKG signaling pathway. The drugs Fenoldopam and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone marrow, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Renal Artery Disease

Diseases related to Renal Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 arteries, anomalies of 30.6 REN NOS3 ALB AGTR1 ACE
2 renal artery obstruction 30.2 REN ACE
3 hypertension, diastolic 30.2 REN ACE
4 fibromuscular dysplasia 30.1 REN AGTR1 AGT ACE
5 renovascular hypertension 30.1 REN NPPA NOS3 AGTR1 ACE
6 generalized atherosclerosis 30.1 REN ALB ACE
7 microvascular complications of diabetes 3 29.8 REN ALB AGTR1 ACE
8 peripheral vascular disease 29.8 NOS3 EPO ALB ACE
9 coronary heart disease 1 29.7 NOS3 AGTR1 ACE
10 peripheral artery disease 29.7 NOS3 CST3 ACE
11 hypertensive retinopathy 29.5 REN ALB AGTR1 ACE
12 acute kidney failure 29.5 REN NPPA CST3 ALB
13 portal hypertension 29.5 NOS3 ALB AGTR1 ACE
14 cerebrovascular disease 29.4 REN NPPA AGTR1 AGT ACE
15 malignant hypertension 29.2 REN NPPA AGTR1 AGT ACE
16 pulmonary edema 28.9 REN NPPA NOS3 EPO AGTR1 AGT
17 lipoprotein quantitative trait locus 28.8 REN NPPA NOS3 ALB AGTR1 ACE
18 congestive heart failure 28.6 REN NPPA NOS3 EPO ALB AGTR1
19 renal hypertension 28.6 REN NOS3 EPO APOL1 ALB AGTR1
20 vascular disease 28.5 REN NOS3 EPO CST3 ALB AGTR1
21 diabetes mellitus 28.4 REN NOS3 EPO CST3 ALB AGTR1
22 heart disease 27.9 REN NPPA NOS3 EPO CST3 ALB
23 kidney disease 27.7 REN NPPA NOS3 EPO CST3 ALB
24 end stage renal disease 27.5 REN NOS3 EPO CST3 APOL1 ALB
25 hypertension, essential 27.3 REN NPPA NOS3 EPO CST3 APOL1
26 chronic kidney disease 27.1 REN NPPA NOS3 EPO CST3 APOL1
27 cholesterol embolism 10.4 REN ACE
28 malignant secondary hypertension 10.4 REN AGTR1
29 vasculogenic impotence 10.4 NPPA ACE
30 acute diffuse nephritis 10.4 EPO ACE
31 iga nephropathy 1 10.4 AGTR1 ACE
32 anterolateral myocardial infarction 10.4 NPPA ACE
33 chronic mountain sickness 10.4 NOS3 EPO
34 glomerular disease 10.4 ALB ACE
35 malignant renovascular hypertension 10.4 REN AGTR1
36 pseudohyperkalemia, familial, 2, due to red cell leak 10.4 REN ACE
37 idiopathic edema 10.4 NPPA ACE
38 meningococcal infection 10.4 AGTR1 AGT
39 idiopathic nephrotic syndrome 10.3 ALB ACE
40 iritis 10.3 EPO ACE
41 plantar fascial fibromatosis 10.3 AGTR1 AGT
42 intracranial embolism 10.3 ALB ACE
43 testicular torsion 10.3 NOS3 ACE
44 left bundle branch hemiblock 10.3 REN ACE
45 idiopathic hypercalciuria 10.3 REN NPPA
46 coronary artery vasospasm 10.3 NOS3 ACE
47 constrictive pericarditis 10.3 ALB ACE
48 potter's syndrome 10.3 REN AGT ACE
49 arteriolosclerosis 10.3 REN ALB
50 background diabetic retinopathy 10.3 ALB ACE

Comorbidity relations with Renal Artery Disease via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Acute Kidney Failure
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Kidney Disease
Malignant Renovascular Hypertension Mitral Valve Disease
Peripheral Vascular Disease Renal Artery Atheroma

Graphical network of the top 20 diseases related to Renal Artery Disease:



Diseases related to Renal Artery Disease

Symptoms & Phenotypes for Renal Artery Disease

MGI Mouse Phenotypes related to Renal Artery Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 ACE AGT AGTR1 ALB CST3 EPO
2 homeostasis/metabolism MP:0005376 9.85 ACE AGT AGTR1 ALB CST3 EPO
3 muscle MP:0005369 9.5 AGT ALB CST3 EPO NOS3 NPPA
4 renal/urinary system MP:0005367 9.17 ACE AGT AGTR1 ALB NOS3 NPPA

Drugs & Therapeutics for Renal Artery Disease

Drugs for Renal Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fenoldopam Approved Phase 2 67227-57-0, 67227-56-9 3341
2
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
3 Dopamine Agents Phase 2
4 Neurotransmitter Agents Phase 2
5 Dopamine agonists Phase 2
6 Antihypertensive Agents Phase 2
7 Vasodilator Agents Phase 2
8
Testosterone Approved, Experimental, Investigational 58-22-0, 481-30-1 10204 6013
9 Liver Extracts
10 Hormone Antagonists
11 Androgens
12 Hormones

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Multicenter, Open-label Study to Evaluate the Safety and Efficacy (by Blinded Reading) of Gadobutrol-enhanced Magnetic Resonance Angiography (MRA) After a Single Injection of 0.1 mmol/kg of Gadobutrol in Subjects With Known or Suspected Renal Artery Disease Completed NCT01344460 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
2 Multicenter, Open-label Study of the Safety (Open-label) and Efficacy (Open-label and Blinded Reader) of a Single Administration of Approximately 0.1 mmol/kg of Magnevist® Injection-enhanced Magnetic Resonance Arteriography (MRA) and 2-dimensional-time-of-flight (2D-TOF) MRA in Patients With Known or Suspected Renal Artery Disease Undergoing MRA of the Renal Arteries With Intra-arterial Digital Subtraction Arteriography (i.a. DSA) as the Standard of Reference Completed NCT00310557 Phase 3 Gadopentetate dimeglumine (Magnevist)
3 A Pilot Study to Investigate Fenoldopam Usage in the Prevention of Postoperative Renal Dysfunction in Patients at a High Risk for Renal Impairment During Cariopulmonary Bypass for Cardiac Surgery Completed NCT00467181 Phase 2 Fenoldopam
4 Comparison of Autologous Transplantation of Bone Marrow Mesenchymal Stem Cells and Mononuclear Cells on Diabetic Critical Limb Ischemia and Foot Ulcer Completed NCT00955669 Phase 1
5 Renal Atherosclerotic Revascularization Evaluation: RAVE Study Completed NCT00127738
6 REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent Completed NCT00631540
7 Evaluation of Clinical Benefits of B-Flow With the LOGIQ E9 Ultrasound System Completed NCT02008097
8 Evaluation of Renal Angioplasty on Atherosclerotic Stenosis Since 2010 Completed NCT03686358
9 Observational Study on Peripheral Vascular Disease, Glucometabolic Status, and Type D Personality in Patients With Acute Myocardial Infarction. Completed NCT01452178
10 Diagnosis and Treatment of Patients With Heart and Vascular Disease (Training Protocol) Recruiting NCT00001458
11 Serum Androgen Levels as a Marker for the Severity of Preeclampsia Active, not recruiting NCT03744988

Search NIH Clinical Center for Renal Artery Disease

Genetic Tests for Renal Artery Disease

Anatomical Context for Renal Artery Disease

MalaCards organs/tissues related to Renal Artery Disease:

40
Kidney, Heart, Bone Marrow, Bone, Liver, Testes, Brain

Publications for Renal Artery Disease

Articles related to Renal Artery Disease:

(show top 50) (show all 310)
# Title Authors PMID Year
1
Non-coronary atherosclerotic cardiovascular disease in patients with familial hypercholesterolaemia. 61
32096673 2020
2
Histologic and morphologic character of pediatric renal artery occlusive disease. 61
32276022 2020
3
Renal Frame Count and High Blood Pressure. 61
32141485 2020
4
Combination of Renal Angioplasty and Angiotensin-converting-enzyme Inhibitor Can Reduce Proteinuria in Patients with Bilateral Renal Artery Disease. 61
30799351 2019
5
An investigation of the detection capability of pulsed wave duplex Doppler of low grade stenosis using ultrasound contrast agent microbubbles - An in-vitro study. 61
31004864 2019
6
Cardiac function response to stenting in atherosclerotic renal artery disease with and without heart failure: results from the Carmel study. 61
30614643 2019
7
Association of renal artery stenosis with left ventricular remodeling in patients coexisting with renovascular and coronary artery disease. 61
30547720 2019
8
Surgical Renovascular Reconstruction for Renal Artery Stenosis and Aneurysm: Long-Term Durability and Survival. 61
30343992 2019
9
Blood pressure decreases after revascularization in atherosclerotic renal artery disease: A cohort study based on a multidisciplinary meeting. 61
31233539 2019
10
Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency. 61
29555535 2018
11
Renal artery anatomy assessed by quantitative analysis of selective renal angiography in 1,000 patients with hypertension. 61
29633939 2018
12
Anti-hypertensive treatment in peripheral artery disease. 61
29459079 2018
13
Efficacy and safety of gadobutrol-enhanced MRA of the renal arteries: Results from GRAMS (Gadobutrol-enhanced renal artery MRA study), a prospective, intraindividual multicenter phase 3 blinded study. 61
28574637 2018
14
Analysis of renal artery morphometery in adults: A study conducted by using Multidetector computed Tomography Angiography. 61
29067070 2017
15
Lipid and other management to improve arterial disease and survival in end stage renal disease. 61
28110562 2017
16
Predictors of cardiac benefits of renal artery stenting from a multicentre retrospective registry. 61
29469905 2017
17
Renal Arterial Disease and Hypertension. 61
27884236 2017
18
Anatomical and procedural determinants of catheter-based renal denervation. 61
27617388 2016
19
Renovascular heart failure: heart failure in patients with atherosclerotic renal artery disease. 61
27052017 2016
20
To Stent or Not to Stent? Update on Revascularization for Atherosclerotic Renovascular Disease. 61
27130448 2016
21
Improvement of left ventricular filling and pulmonary artery pressure following unilateral renal artery total occlusion stenting in a patient with recurrent congestive heart failure complicated by renovascular hypertension and renal failure. 61
27774260 2015
22
Fibromuscular dysplasia of cervicocephalic arteries: Prevalence of multisite involvement and prognosis. 61
25857462 2015
23
Decade in review--peripheral vascular disease: 10 Years of breakthroughs in peripheral vascular disease. 61
25267425 2014
24
Where and when device therapy may be useful in the management of drug-resistant hypertension. 61
25326400 2014
25
Prevalence of renal artery disease and its prognostic significance in patients undergoing coronary bypass grafting. 61
25150754 2014
26
Bilateral renal artery involvement of erdheim-chester disease. 61
24704054 2014
27
Ex vivo renal artery reconstruction for complex renal artery disease. 61
24594447 2014
28
Our preoccupation with renal artery disease in patients undergoing cardiac surgery: much ado about nothing? 61
24161327 2014
29
Renal artery stenosis: epidemiology and treatment. 61
24868169 2014
30
Prevalence and predictors of renal artery stenosis in patients undergoing peripheral and coronary angiography. 61
23589188 2013
31
Ischemic nephropathy: more than a simple renal artery narrowing. 61
23485531 2013
32
Prospective monitoring N-terminal pro-brain natriuretic peptide during natural progression of atherosclerotic renal artery stenosis in elderly. 61
23153984 2013
33
Long-term follow-up of patients with atherosclerotic renal artery disease. 61
23321402 2013
34
Prevalence and clinical outcome of polyvascular atherosclerotic disease in patients undergoing coronary intervention. 61
23018634 2013
35
Role of MDCT angiography in selection and presurgical planning of potential renal donors. 61
23096176 2012
36
Evaluation of renal artery in hypertensive patients by unenhanced MR angiography using spatial labeling with multiple inversion pulses sequence and by CT angiography. 61
23096191 2012
37
Percutaneous Transluminal Revascularization following an Angiotensin Receptor Blocker: Successful Treatment for Flash Pulmonary Edema and Hyponatremic Hypertensive Syndrome. 61
22969774 2012
38
Effects of olmesartan on arterial stiffness in rats with chronic renal failure. 61
22694778 2012
39
Renal dysfunction in acute and chronic heart failure: prevalence, incidence and prognosis. 61
22426973 2012
40
Chapter III: Management of cardiovascular risk factors and medical therapy. 61
22172471 2011
41
MD CT angiography and MR angiography of nonatherosclerotic renal artery disease. 61
21681628 2011
42
Vanishing renal artery disease: a segmental arterial mediolysis story. 61
21997510 2011
43
Acute renal artery occlusion: making the case for renal artery revascularization. 61
21855421 2011
44
Atherosclerotic renal artery stenosis and renal artery stenting: an evolving therapeutic option. 61
21985547 2011
45
Is there an indication for embolic protection in renal artery intervention? 61
21550512 2011
46
Successful hybrid procedure in flash pulmonary edema. 61
21566313 2011
47
Anesthetic management of patients undergoing extra-anatomic renal bypass surgery for renovascular hypertension. 61
21636929 2011
48
Endovascular and open revascularization for nonatherosclerotic renal artery disease. 61
21249718 2011
49
Acute renal artery stent thrombosis with a solitary functioning kidney. 61
20598850 2010
50
Renal artery thrombosis caused by stent fracture: the risk of undiagnosed renal artery entrapment. 61
20831998 2010

Variations for Renal Artery Disease

Expression for Renal Artery Disease

Search GEO for disease gene expression data for Renal Artery Disease.

Pathways for Renal Artery Disease

Pathways related to Renal Artery Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.47 NOS3 EPO AGTR1 AGT
2
Show member pathways
12.06 NPPA NOS3 AGTR1 AGT
3
Show member pathways
11.92 NPPA NOS3 AGTR1 AGT
4 11.58 NPPA NOS3 EPO
5 11.5 NOS3 AGTR1 AGT
6
Show member pathways
11.26 REN NOS3 AGTR1 AGT ACE
7 10.86 REN NPPA AGTR1 AGT ACE
8 10.79 CST3 ACE

GO Terms for Renal Artery Disease

Cellular components related to Renal Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 REN NPPA EPO CST3 APOL1 ALB
2 blood microparticle GO:0072562 9.33 APOL1 ALB AGT
3 extracellular space GO:0005615 9.23 REN NPPA EPO CST3 APOL1 ALB

Biological processes related to Renal Artery Disease according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.83 NPPA CST3 APOL1 ALB
2 response to hypoxia GO:0001666 9.8 NPPA EPO CST3
3 response to lipopolysaccharide GO:0032496 9.79 REN NOS3 EPO
4 kidney development GO:0001822 9.71 REN AGTR1 AGT ACE
5 blood vessel remodeling GO:0001974 9.63 NOS3 AGT ACE
6 positive regulation of blood pressure GO:0045777 9.61 AGT ACE
7 nitric oxide mediated signal transduction GO:0007263 9.61 NOS3 AGT
8 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.6 AGTR1 AGT
9 positive regulation of cellular protein metabolic process GO:0032270 9.59 AGTR1 AGT
10 cell growth involved in cardiac muscle cell development GO:0061049 9.58 NPPA AGT
11 amyloid-beta metabolic process GO:0050435 9.58 REN ACE
12 low-density lipoprotein particle remodeling GO:0034374 9.57 AGTR1 AGT
13 angiotensin maturation GO:0002003 9.56 REN ACE
14 positive regulation of cholesterol esterification GO:0010873 9.55 AGTR1 AGT
15 positive regulation of NAD(P)H oxidase activity GO:0033864 9.54 AGTR1 AGT
16 regulation of vasoconstriction GO:0019229 9.54 AGTR1 AGT ACE
17 regulation of renal sodium excretion GO:0035813 9.51 AGTR1 AGT
18 regulation of blood vessel diameter GO:0097746 9.5 NOS3 AGTR1 ACE
19 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.49 AGTR1 AGT
20 regulation of blood volume by renin-angiotensin GO:0002016 9.48 REN AGT
21 regulation of renal output by angiotensin GO:0002019 9.43 AGT ACE
22 vasodilation GO:0042311 9.43 NPPA NOS3 AGT
23 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.33 AGTR1 AGT ACE
24 renin-angiotensin regulation of aldosterone production GO:0002018 9.13 REN AGTR1 AGT
25 regulation of blood pressure GO:0008217 9.02 REN NPPA NOS3 AGT ACE

Molecular functions related to Renal Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 NPPA EPO AGT
2 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE

Sources for Renal Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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