MCID: RNL097
MIFTS: 42

Renal Artery Disease

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Renal Artery Disease

MalaCards integrated aliases for Renal Artery Disease:

Name: Renal Artery Disease 12 15 73
Vascular Disorder of Kidney 12
Renal Vascular Disorder 73
Renal Vascular Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2388
ICD9CM 35 593.81
NCIt 50 C35338
SNOMED-CT 68 16934004

Summaries for Renal Artery Disease

MalaCards based summary : Renal Artery Disease, also known as vascular disorder of kidney, is related to arteries, anomalies of and vascular disease. An important gene associated with Renal Artery Disease is REN (Renin), and among its related pathways/superpathways are p70S6K Signaling and Development Angiotensin activation of ERK. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and heart, and related phenotypes are cardiovascular system and behavior/neurological

Related Diseases for Renal Artery Disease

Diseases related to Renal Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 arteries, anomalies of 30.0 REN NOS3 AGTR1 AGT ACE
2 vascular disease 29.3 ACE NOS3 REN
3 renovascular hypertension 29.3 REN NOS3 AGTR1 ACE
4 end stage renal failure 29.1 EPO AGTR1 AGT ACE
5 malignant hypertension 28.9 REN AGTR1 AGT ACE
6 hypertension, essential 28.8 REN NOS3 AGTR1 AGT ACE
7 diabetes mellitus 28.7 REN NOS3 EPO AGTR1 AGT ACE
8 hyporeninemic hypoaldosteronism 10.1 ACE REN
9 hypoaldosteronism 10.1 ACE REN
10 renal artery obstruction 10.1 ACE REN
11 hypertension, diastolic 10.1 ACE REN
12 hypertensive retinopathy 10.1 ACE REN
13 orthostatic proteinuria 10.1 ACE REN
14 malignant essential hypertension 10.1 ACE REN
15 hepatorenal syndrome 10.1 ACE REN
16 pseudohyperkalemia, familial, 2, due to red cell leak 10.1 ACE REN
17 arteritic anterior ischemic optic neuropathy 10.1 ACE NOS3
18 hypertensive nephropathy 10.1 ACE AGTR1
19 congenital hepatic fibrosis 10.1 AGTR1 REN
20 heart valve disease 10.1 ACE REN
21 nephrosclerosis 10.1 ACE AGTR1
22 carotid artery disease 10.1 ACE REN
23 vasculogenic impotence 10.0 ACE NOS3
24 hypokalemia 10.0 ACE REN
25 ischemic heart disease 10.0 ACE NOS3
26 sexual disorder 10.0 ACE NOS3
27 angina pectoris 10.0 ACE NOS3
28 diabetic neuropathy 10.0 ACE EPO
29 hepatic vascular disease 10.0 NOS3 REN
30 peripheral artery disease 10.0 ACE NOS3
31 chronic mountain sickness 10.0 EPO NOS3
32 limb ischemia 10.0 ACE NOS3
33 pediatric hypertension 10.0 ACE AGT
34 potter's syndrome 10.0 AGT REN
35 ureteral obstruction 10.0 AGTR1 EPO
36 hypertensive encephalopathy 10.0 REN EPO ACE
37 pure autonomic failure 10.0 REN EPO ACE
38 hyperaldosteronism, familial, type i 9.9 AGT REN
39 iga glomerulonephritis 9.9 ACE AGTR1 REN
40 cerebrovascular disease 9.9 ACE AGTR1 REN
41 migraine with aura 9.9 ACE NOS3
42 meningococcal infection 9.9 AGT AGTR1
43 gitelman syndrome 9.9 AGT REN
44 pulmonary edema 9.9 ACE NOS3 REN
45 orthostatic intolerance 9.9 AGTR1 NOS3
46 sleep apnea 9.9 ACE NOS3 REN
47 glucose metabolism disease 9.9 ACE NOS3 REN
48 acquired metabolic disease 9.9 ACE NOS3 REN
49 renal fibrosis 9.9 AGTR1 REN
50 acute mountain sickness 9.9 ACE AGTR1 NOS3

Comorbidity relations with Renal Artery Disease via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Kidney Disease Malignant Renovascular Hypertension
Mitral Valve Disease Peripheral Vascular Disease
Renal Artery Atheroma

Graphical network of the top 20 diseases related to Renal Artery Disease:



Diseases related to Renal Artery Disease

Symptoms & Phenotypes for Renal Artery Disease

MGI Mouse Phenotypes related to Renal Artery Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 ACE AGT AGTR1 EPO NOS3 REN
2 behavior/neurological MP:0005386 9.85 ACE AGT AGTR1 NOS3 REN
3 homeostasis/metabolism MP:0005376 9.85 ACE AGT AGTR1 EPO NOS3 REN
4 hematopoietic system MP:0005397 9.8 ACE AGTR1 EPO NOS3 REN
5 immune system MP:0005387 9.8 ACE AGT AGTR1 EPO NOS3 REN
6 adipose tissue MP:0005375 9.78 ACE AGT AGTR1 NOS3
7 mortality/aging MP:0010768 9.63 ACE AGT AGTR1 EPO NOS3 REN
8 liver/biliary system MP:0005370 9.56 ACE AGT EPO NOS3
9 muscle MP:0005369 9.26 AGT EPO NOS3 REN
10 renal/urinary system MP:0005367 9.02 ACE AGT AGTR1 NOS3 REN

Drugs & Therapeutics for Renal Artery Disease

Drugs for Renal Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gadobutrol Enhanced MRA of the Renal Arteries Completed NCT01344460 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
2 Magnevist® Injection-enhanced MRA Compared to Non Contrast MRA for the Detection of Stenosis of the Renal Arteries Completed NCT00310557 Phase 3 Gadopentetate dimeglumine (Magnevist)
3 Safety and Effectiveness Study of the HERCULINK 14 Stent to Treat Renal Artery Disease Terminated NCT00180544 Phase 3
4 Vastmanland Myocardial Infarction Study (VaMIS) Completed NCT01452178
5 Clinical Benefits of B-Flow Ultrasound Completed NCT02008097 Not Applicable
6 REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent Completed NCT00631540 Not Applicable

Search NIH Clinical Center for Renal Artery Disease

Genetic Tests for Renal Artery Disease

Anatomical Context for Renal Artery Disease

MalaCards organs/tissues related to Renal Artery Disease:

41
Kidney, Bone, Heart, Liver, Bone Marrow

Publications for Renal Artery Disease

Articles related to Renal Artery Disease:

(show top 50) (show all 84)
# Title Authors Year
1
Renovascular heart failure: heart failure in patients with atherosclerotic renal artery disease. ( 27052017 )
2016
2
Our preoccupation with renal artery disease in patients undergoing cardiac surgery: much ado about nothing? ( 24161327 )
2014
3
Prevalence of renal artery disease and its prognostic significance in patients undergoing coronary bypass grafting. ( 25150754 )
2014
4
Ex vivo renal artery reconstruction for complex renal artery disease. ( 24594447 )
2014
5
Long-term follow-up of patients with atherosclerotic renal artery disease. ( 23321402 )
2013
6
Vanishing renal artery disease: a segmental arterial mediolysis story. ( 21997510 )
2011
7
MD CT angiography and MR angiography of nonatherosclerotic renal artery disease. ( 21681628 )
2011
8
Endovascular and open revascularization for nonatherosclerotic renal artery disease. ( 21249718 )
2011
9
Late outcomes of endovascular and open revascularization for nonatherosclerotic renal artery disease. ( 20855752 )
2010
10
Atherosclerotic renal artery disease and heart failure: questions in mind. ( 20466691 )
2010
11
Update on the management of atherosclerotic renal artery disease. ( 19202521 )
2009
12
Low frequency of renal artery disease in young ischemic stroke patients. ( 18564822 )
2008
13
Relationship between coronary and renal artery disease and associated risk factors in hypertensive and diabetic patients undergoing coronary angiography. ( 19110812 )
2008
14
Atherosclerotic Peripheral Vascular Disease Symposium II: intervention for renal artery disease. ( 19106410 )
2008
15
A multi-center, comparative, phase 3 study to determine the efficacy of gadofosveset-enhanced magnetic resonance angiography for evaluation of renal artery disease. ( 17499952 )
2008
16
Novel stent system for accurate placement in aorto-ostial renal artery disease: preclinical study in porcine renal artery model. ( 17574168 )
2007
17
Clinical insights into the diagnosis and management of atherosclerotic renal artery disease. ( 16901412 )
2006
18
Usefulness of translesional pressure gradient and pharmacological provocation for the assessment of intermediate renal artery disease. ( 16892443 )
2006
19
Surgical revascularization for renal artery disease: current status. ( 15720339 )
2005
20
Primary hyperaldosteronism: a frequent cause of residual hypertension after successful endovascular treatment of renal artery disease. ( 16208147 )
2005
21
Factors predicting outcome in a cohort of patients with atherosclerotic renal artery disease diagnosed by magnetic resonance angiography. ( 16310572 )
2005
22
Genetic risk of atherosclerotic renal artery disease: the candidate gene approach in a renal angiography cohort. ( 15326089 )
2004
23
Renal artery disease: diagnosis and management. ( 15029399 )
2004
24
Laparoscopic nephron-sparing surgery in the presence of renal artery disease. ( 14624925 )
2003
25
Atherosclerotic renal artery disease. ( 12472042 )
2002
26
Long-term results of surgical revascularization for renal artery disease. ( 11791498 )
2001
27
Predicting the outcome of invasive treatment of renal artery disease. ( 10672137 )
2000
28
Contemporary management of renal cell carcinoma with coexistent renal artery disease: update of the Cleveland Clinic experience. ( 10962299 )
2000
29
Kidney transplantation from living donors with renal artery disease. ( 11119850 )
2000
30
Prevalence of angiographic atherosclerotic renal artery disease and its relationship to the anatomical extent of peripheral vascular atherosclerosis. ( 10052486 )
1999
31
Renal artery disease in the elderly. ( 10518251 )
1999
32
Revascularization in atherosclerotic renal artery disease. ( 9507232 )
1998
33
Individual kidney function in atherosclerotic renal-artery disease. ( 9568883 )
1998
34
Use of the splenic and hepatic artery for renal revascularization in patients with atherosclerotic renal artery disease. ( 9061145 )
1997
35
Long-term survival after surgical revascularization for atherosclerotic renal artery disease. ( 9186318 )
1997
36
A unique case of renovascular hypertension caused by combined renal artery disease. ( 7584936 )
1995
37
The contemporary role of extra-anatomical surgical renal revascularization in patients with atherosclerotic renal artery disease. ( 7752320 )
1995
38
Surgery for occlusive renal artery disease: immediate and long-term results. ( 7900483 )
1995
39
Defining the role of renal angiography in the diagnosis of renal artery disease. ( 7942828 )
1994
40
The durability of different reconstructive techniques for atherosclerotic renal artery disease. ( 8028093 )
1994
41
Percutaneous angioplasty for atherosclerotic renal artery disease: effect on renal function in azotemic patients. ( 8087830 )
1994
42
Role of duplex ultrasonography in screening for significant renal artery disease. ( 8178389 )
1994
43
Management of atherosclerotic renal artery disease in younger patients. ( 8254782 )
1994
44
Effect of captopril on the renal veno-arterial gradient of erythropoietin and oxygen in unilateral renal artery disease. ( 8140397 )
1993
45
Effect of captopril on renal extraction of renin, angiotensin II, atrial natriuretic peptide and vasopressin, and renal vein renin ratio in patients with arterial hypertension and unilateral renal artery disease. ( 8272217 )
1993
46
Management of renal cell carcinoma with coexistent renal artery disease. ( 8345589 )
1993
47
Fibro-muscular renal artery disease treated by extracorporeal vascular reconstruction and renal autotransplantation: short- and long-term results. ( 1397339 )
1992
48
Angioplasty for the treatment of azotemia and renovascular hypertension in atherosclerotic renal artery disease. ( 1825044 )
1991
49
Role of duplex scanning for the detection of atherosclerotic renal artery disease. ( 1895675 )
1991
50
Evaluation and preparation for surgical treatment of renal artery disease. ( 2973804 )
1988

Variations for Renal Artery Disease

Expression for Renal Artery Disease

Search GEO for disease gene expression data for Renal Artery Disease.

Pathways for Renal Artery Disease

GO Terms for Renal Artery Disease

Biological processes related to Renal Artery Disease according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.74 EPO NOS3 REN
2 regulation of cell growth GO:0001558 9.64 AGT AGTR1
3 positive regulation of inflammatory response GO:0050729 9.63 AGT AGTR1
4 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.63 AGT AGTR1
5 positive regulation of protein tyrosine kinase activity GO:0061098 9.62 ACE AGT
6 positive regulation of reactive oxygen species metabolic process GO:2000379 9.62 AGT AGTR1
7 positive regulation of blood pressure GO:0045777 9.61 ACE AGT
8 vasodilation GO:0042311 9.61 AGT NOS3
9 nitric oxide mediated signal transduction GO:0007263 9.6 AGT NOS3
10 regulation of blood vessel size GO:0050880 9.59 AGT NOS3
11 positive regulation of cellular protein metabolic process GO:0032270 9.58 AGT AGTR1
12 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.58 AGT AGTR1
13 amyloid-beta metabolic process GO:0050435 9.56 ACE REN
14 kidney development GO:0001822 9.56 ACE AGT AGTR1 REN
15 low-density lipoprotein particle remodeling GO:0034374 9.55 AGT AGTR1
16 regulation of blood vessel diameter GO:0097746 9.54 ACE AGTR1
17 blood vessel remodeling GO:0001974 9.54 ACE AGT NOS3
18 angiotensin maturation GO:0002003 9.52 ACE REN
19 positive regulation of cholesterol esterification GO:0010873 9.51 AGT AGTR1
20 regulation of vasoconstriction GO:0019229 9.5 ACE AGT AGTR1
21 positive regulation of NAD(P)H oxidase activity GO:0033864 9.49 AGT AGTR1
22 regulation of renal sodium excretion GO:0035813 9.48 AGT AGTR1
23 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.46 AGT AGTR1
24 regulation of blood pressure GO:0008217 9.46 ACE AGT NOS3 REN
25 regulation of blood volume by renin-angiotensin GO:0002016 9.43 AGT REN
26 regulation of renal output by angiotensin GO:0002019 9.4 ACE AGT
27 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.13 ACE AGT AGTR1
28 renin-angiotensin regulation of aldosterone production GO:0002018 8.8 AGT AGTR1 REN

Molecular functions related to Renal Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.96 ACE REN
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Renal Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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