MCID: RNL097
MIFTS: 38

Renal Artery Disease

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Renal Artery Disease

MalaCards integrated aliases for Renal Artery Disease:

Name: Renal Artery Disease 12 15 73
Vascular Disorder of Kidney 12
Renal Vascular Disorder 73
Renal Vascular Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2388
ICD9CM 35 593.81
NCIt 50 C35338

Summaries for Renal Artery Disease

MalaCards based summary : Renal Artery Disease, also known as vascular disorder of kidney, is related to arteries, anomalies of and vascular disease. An important gene associated with Renal Artery Disease is REN (Renin), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and HIF-1 signaling pathway. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Renal Artery Disease

Diseases related to Renal Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 arteries, anomalies of 29.1 ACE AGTR1 NOS3 REN
2 vascular disease 28.8 ACE NOS3 REN
3 hyporeninemic hypoaldosteronism 10.5 ACE REN
4 renal artery obstruction 10.5 ACE REN
5 hypertensive retinopathy 10.4 ACE REN
6 orthostatic proteinuria 10.4 ACE REN
7 atrial septal defect 4 10.4 ACE REN
8 malignant essential hypertension 10.4 ACE REN
9 ureteral disease 10.3 ACE REN
10 posterior urethral valves 10.3 ACE AGTR1
11 pseudohyperkalemia, familial, 2, due to red cell leak 10.3 ACE REN
12 hypertensive nephropathy 10.3 ACE AGTR1
13 syndrome of inappropriate antidiuretic hormone 10.3 ACE NPPA
14 idiopathic edema 10.3 ACE NPPA
15 postural hypotension 10.3 NPPA REN
16 interstitial nephritis 10.3 ACE REN
17 congenital hepatic fibrosis 10.3 AGTR1 REN
18 mitral valve insufficiency 10.3 ACE NPPA
19 aortic valve disease 1 10.3 ACE REN
20 nephrosclerosis 10.3 ACE AGTR1
21 hypertensive heart disease 10.2 ACE AGTR1
22 hypokalemia 10.2 ACE REN
23 polycystic kidney disease 1 with or without polycystic liver disease 10.2 ACE REN
24 angina pectoris 10.2 ACE NOS3
25 idiopathic hypercalciuria 10.2 NPPA REN
26 ischemic heart disease 10.2 ACE NOS3
27 sexual disorder 10.2 ACE NOS3
28 arteritic anterior ischemic optic neuropathy 10.2 ACE NOS3
29 pericardial effusion 10.2 NPPA REN
30 acute kidney failure 10.1 NPPA REN
31 peripheral artery disease 10.1 ACE NOS3
32 vesicoureteral reflux 1 10.1 AGTR1 REN
33 hepatic vascular disease 10.1 NOS3 REN
34 central sleep apnea 10.1 NOS3 NPPA
35 limb ischemia 10.1 ACE NOS3
36 migraine with aura 10.0 ACE NOS3
37 hypoaldosteronism 9.9 ACE NPPA REN
38 microvascular complications of diabetes 5 9.9 ACE NOS3
39 hypertension, diastolic 9.9 ACE NPPA REN
40 anuria 9.9 ACE AGTR1 REN
41 fibromuscular dysplasia 9.9 ACE AGTR1 REN
42 hepatorenal syndrome 9.9 ACE NPPA REN
43 renal tubular dysgenesis 9.9 ACE AGTR1 REN
44 microvascular complications of diabetes 3 9.9 ACE AGTR1 REN
45 oligohydramnios 9.9 ACE AGTR1 REN
46 renal fibrosis 9.9 AGTR1 REN
47 renal dysplasia 9.9 ACE AGTR1 REN
48 orthostatic intolerance 9.8 AGTR1 NOS3
49 aortic valve disease 2 9.8 ACE NPPA REN
50 iga glomerulonephritis 9.8 ACE AGTR1 REN

Comorbidity relations with Renal Artery Disease via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Kidney Disease Malignant Renovascular Hypertension
Mitral Valve Disease Peripheral Vascular Disease
Renal Artery Atheroma

Graphical network of the top 20 diseases related to Renal Artery Disease:



Diseases related to Renal Artery Disease

Symptoms & Phenotypes for Renal Artery Disease

MGI Mouse Phenotypes related to Renal Artery Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 NOS3 NPPA REN ACE AGTR1 EPO
2 hematopoietic system MP:0005397 9.8 EPO NOS3 NPPA REN ACE AGTR1
3 homeostasis/metabolism MP:0005376 9.73 EPO NOS3 NPPA REN ACE AGTR1
4 immune system MP:0005387 9.55 EPO NOS3 REN ACE AGTR1
5 muscle MP:0005369 9.26 EPO NOS3 NPPA REN
6 renal/urinary system MP:0005367 9.02 NOS3 NPPA REN ACE AGTR1

Drugs & Therapeutics for Renal Artery Disease

Drugs for Renal Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Gadobutrol Enhanced MRA of the Renal Arteries Completed NCT01344460 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
2 Magnevist® Injection-enhanced MRA Compared to Non Contrast MRA for the Detection of Stenosis of the Renal Arteries Completed NCT00310557 Phase 3 Gadopentetate dimeglumine (Magnevist)
3 Safety and Effectiveness Study of the HERCULINK 14 Stent to Treat Renal Artery Disease Terminated NCT00180544 Phase 3
4 Vastmanland Myocardial Infarction Study (VaMIS) Completed NCT01452178
5 Clinical Benefits of B-Flow Ultrasound Completed NCT02008097 Not Applicable
6 REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent Completed NCT00631540 Not Applicable

Search NIH Clinical Center for Renal Artery Disease

Genetic Tests for Renal Artery Disease

Anatomical Context for Renal Artery Disease

MalaCards organs/tissues related to Renal Artery Disease:

41
Kidney, Liver, Heart

Publications for Renal Artery Disease

Articles related to Renal Artery Disease:

(show all 25)
# Title Authors Year
1
Renovascular heart failure: heart failure in patients with atherosclerotic renal artery disease. ( 27052017 )
2016
2
Our preoccupation with renal artery disease in patients undergoing cardiac surgery: much ado about nothing? ( 24161327 )
2014
3
Prevalence of renal artery disease and its prognostic significance in patients undergoing coronary bypass grafting. ( 25150754 )
2014
4
Ex vivo renal artery reconstruction for complex renal artery disease. ( 24594447 )
2014
5
Long-term follow-up of patients with atherosclerotic renal artery disease. ( 23321402 )
2013
6
Vanishing renal artery disease: a segmental arterial mediolysis story. ( 21997510 )
2011
7
MD CT angiography and MR angiography of nonatherosclerotic renal artery disease. ( 21681628 )
2011
8
Endovascular and open revascularization for nonatherosclerotic renal artery disease. ( 21249718 )
2011
9
Late outcomes of endovascular and open revascularization for nonatherosclerotic renal artery disease. ( 20855752 )
2010
10
Atherosclerotic renal artery disease and heart failure: questions in mind. ( 20466691 )
2010
11
Update on the management of atherosclerotic renal artery disease. ( 19202521 )
2009
12
Low frequency of renal artery disease in young ischemic stroke patients. ( 18564822 )
2008
13
Relationship between coronary and renal artery disease and associated risk factors in hypertensive and diabetic patients undergoing coronary angiography. ( 19110812 )
2008
14
Atherosclerotic Peripheral Vascular Disease Symposium II: intervention for renal artery disease. ( 19106410 )
2008
15
A multi-center, comparative, phase 3 study to determine the efficacy of gadofosveset-enhanced magnetic resonance angiography for evaluation of renal artery disease. ( 17499952 )
2008
16
Novel stent system for accurate placement in aorto-ostial renal artery disease: preclinical study in porcine renal artery model. ( 17574168 )
2007
17
Clinical insights into the diagnosis and management of atherosclerotic renal artery disease. ( 16901412 )
2006
18
Usefulness of translesional pressure gradient and pharmacological provocation for the assessment of intermediate renal artery disease. ( 16892443 )
2006
19
Surgical revascularization for renal artery disease: current status. ( 15720339 )
2005
20
Primary hyperaldosteronism: a frequent cause of residual hypertension after successful endovascular treatment of renal artery disease. ( 16208147 )
2005
21
Factors predicting outcome in a cohort of patients with atherosclerotic renal artery disease diagnosed by magnetic resonance angiography. ( 16310572 )
2005
22
Genetic risk of atherosclerotic renal artery disease: the candidate gene approach in a renal angiography cohort. ( 15326089 )
2004
23
Effect of captopril on the renal veno-arterial gradient of erythropoietin and oxygen in unilateral renal artery disease. ( 8140397 )
1993
24
Effect of captopril on renal extraction of renin, angiotensin II, atrial natriuretic peptide and vasopressin, and renal vein renin ratio in patients with arterial hypertension and unilateral renal artery disease. ( 8272217 )
1993
25
The effect of caffeine on renal vein renin concentration in patients with renal arterial disease. ( 1815652 )
1991

Variations for Renal Artery Disease

Expression for Renal Artery Disease

Search GEO for disease gene expression data for Renal Artery Disease.

Pathways for Renal Artery Disease

Pathways related to Renal Artery Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.36 AGTR1 NOS3
2 11.33 EPO NOS3 NPPA
3 11.27 NOS3 REN
4 10.99 EPO NOS3
5 10.94 ACE AGTR1 REN
6
Show member pathways
10.83 ACE AGTR1 NOS3 REN

GO Terms for Renal Artery Disease

Biological processes related to Renal Artery Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.63 EPO NOS3 REN
2 blood vessel remodeling GO:0001974 9.49 ACE NOS3
3 regulation of vasoconstriction GO:0019229 9.48 ACE AGTR1
4 regulation of blood vessel size GO:0050880 9.43 NOS3 NPPA
5 kidney development GO:0001822 9.43 ACE AGTR1 REN
6 amyloid-beta metabolic process GO:0050435 9.4 ACE REN
7 regulation of blood vessel diameter GO:0097746 9.37 ACE AGTR1
8 angiotensin maturation GO:0002003 9.32 ACE REN
9 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.16 ACE AGTR1
10 renin-angiotensin regulation of aldosterone production GO:0002018 8.96 AGTR1 REN
11 regulation of blood pressure GO:0008217 8.92 ACE NOS3 NPPA REN

Molecular functions related to Renal Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.16 EPO NPPA
2 endopeptidase activity GO:0004175 8.96 ACE REN
3 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Renal Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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