MCID: RNL097
MIFTS: 43

Renal Artery Disease

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Renal Artery Disease

MalaCards integrated aliases for Renal Artery Disease:

Name: Renal Artery Disease 12 15 71
Vascular Disorder of Kidney 12
Renal Vascular Disorder 71
Renal Vascular Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2388
ICD9CM 34 593.81
NCIt 49 C35338
SNOMED-CT 67 16934004
UMLS 71 C0268790 C3640053

Summaries for Renal Artery Disease

MalaCards based summary : Renal Artery Disease, also known as vascular disorder of kidney, is related to renal artery obstruction and fibromuscular dysplasia. An important gene associated with Renal Artery Disease is REN (Renin), and among its related pathways/superpathways are Development Angiotensin activation of ERK and cGMP-PKG signaling pathway. The drugs Dopamine and Fenoldopam have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Renal Artery Disease

Diseases related to Renal Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 311)
# Related Disease Score Top Affiliating Genes
1 renal artery obstruction 30.3 REN ACE
2 fibromuscular dysplasia 30.1 REN AGTR1 AGT ACE
3 renovascular hypertension 30.0 REN NPPA NOS3 AGTR1 ACE
4 hypertension, diastolic 29.9 REN NPPA ACE
5 microvascular complications of diabetes 3 29.8 REN ALB AGTR1 ACE
6 aortic disease 29.5 REN CRP ACE
7 portal hypertension 29.4 NOS3 ALB AGTR1 ACE
8 acute kidney failure 29.3 REN NPPA CST3 ALB
9 arteries, anomalies of 29.3 REN NOS3 CRP ALB AGTR1 AGT
10 aortic aneurysm 29.2 CRP AGTR1 ACE
11 pyelonephritis 29.2 CRP ALB ACE
12 malignant hypertension 29.2 REN NPPA AGTR1 AGT ACE
13 intermittent claudication 29.2 CRP ALB ACE
14 generalized atherosclerosis 29.2 REN CRP ALB ACE
15 hyperuricemia 29.1 REN CRP ALB
16 thrombocytosis 29.1 EPO CRP ALB
17 coronary heart disease 1 28.9 NOS3 CRP AGTR1 ACE
18 peripheral vascular disease 28.9 NOS3 EPO CRP ALB ACE
19 peripheral artery disease 28.7 NOS3 CST3 CRP ACE
20 arteriosclerosis 28.7 NOS3 CST3 CRP ACE
21 hypertensive retinopathy 28.5 REN CRP ALB AGTR1 ACE
22 renal hypertension 28.5 REN NOS3 EPO APOL1 ALB AGTR1
23 cerebrovascular disease 28.5 REN NPPA CRP AGTR1 AGT ACE
24 atherosclerosis susceptibility 28.5 NOS3 CRP ALB AGTR1 ACE
25 coronary artery anomaly 28.0 NPPA NOS3 CRP ALB AGTR1 ACE
26 pulmonary edema 27.9 REN NPPA NOS3 EPO CRP AGTR1
27 vascular disease 27.8 REN NOS3 EPO CST3 CRP ALB
28 congestive heart failure 27.5 REN NPPA NOS3 EPO CRP ALB
29 diabetes mellitus 27.3 REN NOS3 EPO CST3 CRP ALB
30 end stage renal failure 26.9 REN NPPA EPO CST3 CRP ALB
31 heart disease 26.7 REN NPPA NOS3 EPO CST3 CRP
32 hypertension, essential 26.2 REN NPPA NOS3 EPO CST3 CRP
33 kidney disease 26.0 REN NPPA NOS3 EPO CST3 CRP
34 chronic kidney disease 26.0 REN NPPA NOS3 EPO CST3 CRP
35 malignant secondary hypertension 10.4 REN AGTR1
36 alzheimer disease 5 10.4 AGTR1 ACE
37 malignant essential hypertension 10.4 REN ACE
38 vasculogenic impotence 10.4 NPPA ACE
39 iga nephropathy 1 10.4 AGTR1 ACE
40 anterolateral myocardial infarction 10.4 NPPA ACE
41 meningococcal infection 10.4 AGTR1 AGT
42 malignant renovascular hypertension 10.4 REN AGTR1
43 idiopathic edema 10.4 NPPA ACE
44 idiopathic nephrotic syndrome 10.4 ALB ACE
45 chronic mountain sickness 10.4 NOS3 EPO
46 polycystic kidney disease 4 10.4 REN ALB
47 glomerular disease 10.4 ALB ACE
48 malignant hypertensive renal disease 10.4 REN AGTR1
49 plantar fascial fibromatosis 10.4 AGTR1 AGT
50 potter's syndrome 10.3 REN AGT ACE

Comorbidity relations with Renal Artery Disease via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Acute Kidney Failure
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Kidney Disease
Malignant Renovascular Hypertension Mitral Valve Disease
Peripheral Vascular Disease Renal Artery Atheroma

Graphical network of the top 20 diseases related to Renal Artery Disease:



Diseases related to Renal Artery Disease

Symptoms & Phenotypes for Renal Artery Disease

MGI Mouse Phenotypes related to Renal Artery Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 ACE AGT AGTR1 ALB CRP CST3
2 homeostasis/metabolism MP:0005376 9.85 ACE AGT AGTR1 ALB CRP CST3
3 muscle MP:0005369 9.5 AGT ALB CST3 EPO NOS3 NPPA
4 renal/urinary system MP:0005367 9.17 ACE AGT AGTR1 ALB NOS3 NPPA

Drugs & Therapeutics for Renal Artery Disease

Drugs for Renal Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
2
Fenoldopam Approved Phase 2 67227-56-9, 67227-57-0 3341
3 Antihypertensive Agents Phase 2
4 Neurotransmitter Agents Phase 2
5 Dopamine Agents Phase 2
6 Dopamine agonists Phase 2
7 Vasodilator Agents Phase 2
8
Methyltestosterone Approved 58-18-4 6010
9
Testosterone Approved, Experimental, Investigational 58-22-0, 481-30-1 6013 10204
10
Testosterone undecanoate Approved, Investigational 5949-44-0
11
Testosterone enanthate Approved 315-37-7 9416
12
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
13 Hematinics
14 Liver Extracts
15 Estrogens
16 Trace Elements
17 Micronutrients
18 Vitamins
19 Anabolic Agents
20 Antioxidants
21 Hormone Antagonists
22 Nutrients
23 Protective Agents
24 Antineoplastic Agents, Hormonal
25 Testosterone 17 beta-cypionate
26 Hormones
27 Androgens
28 Estrogens, Conjugated (USP)

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Multicenter, Open-label Study to Evaluate the Safety and Efficacy (by Blinded Reading) of Gadobutrol-enhanced Magnetic Resonance Angiography (MRA) After a Single Injection of 0.1 mmol/kg of Gadobutrol in Subjects With Known or Suspected Renal Artery Disease Completed NCT01344460 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
2 Multicenter, Open-label Study of the Safety (Open-label) and Efficacy (Open-label and Blinded Reader) of a Single Administration of Approximately 0.1 mmol/kg of Magnevist® Injection-enhanced Magnetic Resonance Arteriography (MRA) and 2-dimensional-time-of-flight (2D-TOF) MRA in Patients With Known or Suspected Renal Artery Disease Undergoing MRA of the Renal Arteries With Intra-arterial Digital Subtraction Arteriography (i.a. DSA) as the Standard of Reference Completed NCT00310557 Phase 3 Gadopentetate dimeglumine (Magnevist)
3 A Pilot Study to Investigate Fenoldopam Usage in the Prevention of Postoperative Renal Dysfunction in Patients at a High Risk for Renal Impairment During Cariopulmonary Bypass for Cardiac Surgery Completed NCT00467181 Phase 2 Fenoldopam
4 Comparison of Autologous Transplantation of Bone Marrow Mesenchymal Stem Cells and Mononuclear Cells on Diabetic Critical Limb Ischemia and Foot Ulcer Completed NCT00955669 Phase 1
5 Renal Atherosclerotic Revascularization Evaluation: RAVE Study Completed NCT00127738
6 REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent Completed NCT00631540
7 Evaluation of Clinical Benefits of B-Flow With the LOGIQ E9 Ultrasound System Completed NCT02008097
8 Evaluation of Renal Angioplasty on Atherosclerotic Stenosis Since 2010 Completed NCT03686358
9 Observational Study on Peripheral Vascular Disease, Glucometabolic Status, and Type D Personality in Patients With Acute Myocardial Infarction. Completed NCT01452178
10 Diagnosis and Treatment of Patients With Heart and Vascular Disease (Training Protocol) Recruiting NCT00001458
11 Serum Androgen Levels as a Marker for the Severity of Preeclampsia Active, not recruiting NCT03744988

Search NIH Clinical Center for Renal Artery Disease

Genetic Tests for Renal Artery Disease

Anatomical Context for Renal Artery Disease

MalaCards organs/tissues related to Renal Artery Disease:

40
Kidney, Heart, Bone, Liver, Bone Marrow, Testes, Brain

Publications for Renal Artery Disease

Articles related to Renal Artery Disease:

(show top 50) (show all 307)
# Title Authors PMID Year
1
Combination of Renal Angioplasty and Angiotensin-converting-enzyme Inhibitor Can Reduce Proteinuria in Patients with Bilateral Renal Artery Disease. 61
30799351 2019
2
An investigation of the detection capability of pulsed wave duplex Doppler of low grade stenosis using ultrasound contrast agent microbubbles - An in-vitro study. 61
31004864 2019
3
Association of renal artery stenosis with left ventricular remodeling in patients coexisting with renovascular and coronary artery disease. 61
30547720 2019
4
Cardiac function response to stenting in atherosclerotic renal artery disease with and without heart failure: results from the Carmel study. 61
30614643 2019
5
Surgical Renovascular Reconstruction for Renal Artery Stenosis and Aneurysm: Long-Term Durability and Survival. 61
30343992 2019
6
Blood pressure decreases after revascularization in atherosclerotic renal artery disease: A cohort study based on a multidisciplinary meeting. 61
31233539 2019
7
Anatomical and procedural determinants of ambulatory blood pressure lowering following catheter-based renal denervation using radiofrequency. 61
29555535 2018
8
Renal artery anatomy assessed by quantitative analysis of selective renal angiography in 1,000 patients with hypertension. 61
29633939 2018
9
Anti-hypertensive treatment in peripheral artery disease. 61
29459079 2018
10
Efficacy and safety of gadobutrol-enhanced MRA of the renal arteries: Results from GRAMS (Gadobutrol-enhanced renal artery MRA study), a prospective, intraindividual multicenter phase 3 blinded study. 61
28574637 2018
11
Analysis of renal artery morphometery in adults: A study conducted by using Multidetector computed Tomography Angiography. 61
29067070 2017
12
Lipid and other management to improve arterial disease and survival in end stage renal disease. 61
28110562 2017
13
Predictors of cardiac benefits of renal artery stenting from a multicentre retrospective registry. 61
29469905 2017
14
Renal Arterial Disease and Hypertension. 61
27884236 2017
15
Anatomical and procedural determinants of catheter-based renal denervation. 61
27617388 2016
16
Renovascular heart failure: heart failure in patients with atherosclerotic renal artery disease. 61
27052017 2016
17
To Stent or Not to Stent? Update on Revascularization for Atherosclerotic Renovascular Disease. 61
27130448 2016
18
Improvement of left ventricular filling and pulmonary artery pressure following unilateral renal artery total occlusion stenting in a patient with recurrent congestive heart failure complicated by renovascular hypertension and renal failure. 61
27774260 2015
19
Fibromuscular dysplasia of cervicocephalic arteries: Prevalence of multisite involvement and prognosis. 61
25857462 2015
20
Decade in review--peripheral vascular disease: 10 Years of breakthroughs in peripheral vascular disease. 61
25267425 2014
21
Where and when device therapy may be useful in the management of drug-resistant hypertension. 61
25326400 2014
22
Prevalence of renal artery disease and its prognostic significance in patients undergoing coronary bypass grafting. 61
25150754 2014
23
Bilateral renal artery involvement of erdheim-chester disease. 61
24704054 2014
24
Ex vivo renal artery reconstruction for complex renal artery disease. 61
24594447 2014
25
Our preoccupation with renal artery disease in patients undergoing cardiac surgery: much ado about nothing? 61
24161327 2014
26
Renal artery stenosis: epidemiology and treatment. 61
24868169 2014
27
Prevalence and predictors of renal artery stenosis in patients undergoing peripheral and coronary angiography. 61
23589188 2013
28
Prospective monitoring N-terminal pro-brain natriuretic peptide during natural progression of atherosclerotic renal artery stenosis in elderly. 61
23153984 2013
29
Ischemic nephropathy: more than a simple renal artery narrowing. 61
23485531 2013
30
Long-term follow-up of patients with atherosclerotic renal artery disease. 61
23321402 2013
31
Prevalence and clinical outcome of polyvascular atherosclerotic disease in patients undergoing coronary intervention. 61
23018634 2013
32
Evaluation of renal artery in hypertensive patients by unenhanced MR angiography using spatial labeling with multiple inversion pulses sequence and by CT angiography. 61
23096191 2012
33
Role of MDCT angiography in selection and presurgical planning of potential renal donors. 61
23096176 2012
34
Percutaneous Transluminal Revascularization following an Angiotensin Receptor Blocker: Successful Treatment for Flash Pulmonary Edema and Hyponatremic Hypertensive Syndrome. 61
22969774 2012
35
Effects of olmesartan on arterial stiffness in rats with chronic renal failure. 61
22694778 2012
36
Renal dysfunction in acute and chronic heart failure: prevalence, incidence and prognosis. 61
22426973 2012
37
Chapter III: Management of cardiovascular risk factors and medical therapy. 61
22172471 2011
38
MD CT angiography and MR angiography of nonatherosclerotic renal artery disease. 61
21681628 2011
39
Vanishing renal artery disease: a segmental arterial mediolysis story. 61
21997510 2011
40
Acute renal artery occlusion: making the case for renal artery revascularization. 61
21855421 2011
41
Atherosclerotic renal artery stenosis and renal artery stenting: an evolving therapeutic option. 61
21985547 2011
42
Is there an indication for embolic protection in renal artery intervention? 61
21550512 2011
43
Anesthetic management of patients undergoing extra-anatomic renal bypass surgery for renovascular hypertension. 61
21636929 2011
44
Successful hybrid procedure in flash pulmonary edema. 61
21566313 2011
45
Endovascular and open revascularization for nonatherosclerotic renal artery disease. 61
21249718 2011
46
Acute renal artery stent thrombosis with a solitary functioning kidney. 61
20598850 2010
47
Renal artery thrombosis caused by stent fracture: the risk of undiagnosed renal artery entrapment. 61
20831998 2010
48
Late outcomes of endovascular and open revascularization for nonatherosclerotic renal artery disease. 61
20855752 2010
49
Atherosclerotic renal artery disease and heart failure: questions in mind. 61
20466691 2010
50
Diagnosis and treatment of renal artery stenosis. 61
20101256 2010

Variations for Renal Artery Disease

Expression for Renal Artery Disease

Search GEO for disease gene expression data for Renal Artery Disease.

Pathways for Renal Artery Disease

Pathways related to Renal Artery Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.47 NOS3 EPO AGTR1 AGT
2
Show member pathways
12.06 NPPA NOS3 AGTR1 AGT
3
Show member pathways
11.91 NPPA NOS3 AGTR1 AGT
4 11.58 NPPA NOS3 EPO
5 11.5 NOS3 AGTR1 AGT
6
Show member pathways
11.26 REN NOS3 AGTR1 AGT ACE
7 10.86 REN NPPA AGTR1 AGT ACE
8 10.79 CST3 ACE

GO Terms for Renal Artery Disease

Cellular components related to Renal Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 REN NPPA EPO CST3 CRP APOL1
2 blood microparticle GO:0072562 9.33 APOL1 ALB AGT
3 extracellular space GO:0005615 9.28 REN NPPA EPO CST3 CRP APOL1

Biological processes related to Renal Artery Disease according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.81 NPPA CST3 APOL1 ALB
2 kidney development GO:0001822 9.67 REN AGTR1 AGT ACE
3 positive regulation of blood pressure GO:0045777 9.62 AGT ACE
4 nitric oxide mediated signal transduction GO:0007263 9.61 NOS3 AGT
5 vasodilation GO:0042311 9.61 NOS3 AGT
6 blood vessel remodeling GO:0001974 9.61 NOS3 AGT ACE
7 positive regulation of superoxide anion generation GO:0032930 9.6 CRP AGT
8 positive regulation of cellular protein metabolic process GO:0032270 9.59 AGTR1 AGT
9 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.58 AGTR1 AGT
10 cell growth involved in cardiac muscle cell development GO:0061049 9.58 NPPA AGT
11 amyloid-beta metabolic process GO:0050435 9.57 REN ACE
12 low-density lipoprotein particle remodeling GO:0034374 9.56 AGTR1 AGT
13 angiotensin maturation GO:0002003 9.55 REN ACE
14 positive regulation of cholesterol esterification GO:0010873 9.54 AGTR1 AGT
15 positive regulation of NAD(P)H oxidase activity GO:0033864 9.52 AGTR1 AGT
16 regulation of vasoconstriction GO:0019229 9.5 AGTR1 AGT ACE
17 regulation of renal sodium excretion GO:0035813 9.49 AGTR1 AGT
18 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.48 AGTR1 AGT
19 regulation of blood volume by renin-angiotensin GO:0002016 9.46 REN AGT
20 regulation of blood vessel diameter GO:0097746 9.43 NOS3 AGTR1 ACE
21 regulation of renal output by angiotensin GO:0002019 9.4 AGT ACE
22 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.33 AGTR1 AGT ACE
23 renin-angiotensin regulation of aldosterone production GO:0002018 9.13 REN AGTR1 AGT
24 regulation of blood pressure GO:0008217 9.02 REN NPPA NOS3 AGT ACE

Molecular functions related to Renal Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 NPPA EPO AGT
2 bradykinin receptor binding GO:0031711 8.62 AGTR1 ACE

Sources for Renal Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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