MCID: RNL097
MIFTS: 42

Renal Artery Disease

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Renal Artery Disease

MalaCards integrated aliases for Renal Artery Disease:

Name: Renal Artery Disease 12 15 74
Vascular Disorder of Kidney 12
Renal Vascular Disorder 74
Renal Vascular Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2388
ICD9CM 36 593.81
NCIt 51 C35338
SNOMED-CT 69 16934004

Summaries for Renal Artery Disease

MalaCards based summary : Renal Artery Disease, also known as vascular disorder of kidney, is related to arteries, anomalies of and end stage renal failure. An important gene associated with Renal Artery Disease is REN (Renin), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and Angiogenesis (CST). The drugs Antihypertensive Agents and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Renal Artery Disease

Diseases related to Renal Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 arteries, anomalies of 30.3 ACE AGTR1 NOS3 REN
2 end stage renal failure 29.3 ACE AGTR1 EPO
3 vascular disease 29.2 ACE NOS3 REN
4 malignant hypertension 28.9 ACE AGTR1 NPPA REN
5 renovascular hypertension 28.8 ACE AGTR1 NOS3 NPPA REN
6 hypertension, essential 28.6 ACE AGTR1 NOS3 NPPA REN
7 diabetes mellitus 28.5 ACE AGTR1 EPO NOS3 REN
8 congestive heart failure 28.2 ACE AGTR1 EPO NPPA REN
9 renal artery obstruction 10.2 ACE REN
10 hypertension, diastolic 10.2 ACE REN
11 hypertensive retinopathy 10.2 ACE REN
12 orthostatic proteinuria 10.2 ACE REN
13 malignant essential hypertension 10.2 ACE REN
14 anterolateral myocardial infarction 10.2 ACE NPPA
15 pseudohyperkalemia, familial, 2, due to red cell leak 10.1 ACE REN
16 posterior urethral valves 10.1 ACE AGTR1
17 hypertensive nephropathy 10.1 ACE AGTR1
18 syndrome of inappropriate antidiuretic hormone 10.1 ACE NPPA
19 microvascular complications of diabetes 3 10.1 ACE AGTR1
20 idiopathic edema 10.1 ACE NPPA
21 mitral valve insufficiency 10.1 ACE NPPA
22 arteritic anterior ischemic optic neuropathy 10.1 ACE NOS3
23 congenital hepatic fibrosis 10.1 AGTR1 REN
24 nephrosclerosis 10.1 ACE AGTR1
25 interstitial nephritis 10.1 ACE REN
26 hypertensive heart disease 10.1 ACE AGTR1
27 obstructive nephropathy 10.1 ACE REN
28 carotid artery disease 10.1 ACE REN
29 idiopathic hypercalciuria 10.1 NPPA REN
30 hypokalemia 10.1 ACE REN
31 vesicoureteral reflux 1 10.1 AGTR1 REN
32 sexual disorder 10.1 ACE NOS3
33 angina pectoris 10.1 ACE NOS3
34 pericardial effusion 10.1 NPPA REN
35 acute kidney failure 10.1 NPPA REN
36 hepatic vascular disease 10.0 NOS3 REN
37 peripheral artery disease 10.0 ACE NOS3
38 central sleep apnea 10.0 NOS3 NPPA
39 limb ischemia 10.0 ACE NOS3
40 aortic valve disease 1 10.0 ACE REN
41 hypoaldosteronism 9.9 ACE NPPA REN
42 anuria 9.9 ACE AGTR1 REN
43 fibromuscular dysplasia 9.9 ACE AGTR1 REN
44 hepatorenal syndrome 9.9 ACE NPPA REN
45 renal tubular dysgenesis 9.9 ACE AGTR1 REN
46 renal fibrosis 9.9 AGTR1 REN
47 heart valve disease 9.9 ACE NPPA REN
48 oligohydramnios 9.9 ACE AGTR1 REN
49 renal dysplasia 9.9 ACE AGTR1 REN
50 iga glomerulonephritis 9.9 ACE AGTR1 REN

Comorbidity relations with Renal Artery Disease via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Kidney Disease Malignant Renovascular Hypertension
Mitral Valve Disease Peripheral Vascular Disease
Renal Artery Atheroma

Graphical network of the top 20 diseases related to Renal Artery Disease:



Diseases related to Renal Artery Disease

Symptoms & Phenotypes for Renal Artery Disease

MGI Mouse Phenotypes related to Renal Artery Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 ACE AGTR1 EPO NOS3 NPPA REN
2 hematopoietic system MP:0005397 9.8 ACE AGTR1 EPO NOS3 NPPA REN
3 homeostasis/metabolism MP:0005376 9.73 ACE AGTR1 EPO NOS3 NPPA REN
4 immune system MP:0005387 9.55 ACE AGTR1 EPO NOS3 REN
5 muscle MP:0005369 9.26 EPO NOS3 NPPA REN
6 renal/urinary system MP:0005367 9.02 ACE AGTR1 NOS3 NPPA REN

Drugs & Therapeutics for Renal Artery Disease

Drugs for Renal Artery Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antihypertensive Agents Phase 4,Phase 3,Not Applicable
2 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3
3
Amlodipine Approved Phase 3 88150-42-9 2162
4
Angiotensin II Approved, Investigational Phase 3 11128-99-7, 68521-88-0, 4474-91-3 172198
5
Candesartan cilexetil Approved Phase 3 145040-37-5 2540
6
Atorvastatin Approved Phase 3 134523-00-5 60823
7
Celecoxib Approved, Investigational Phase 3 169590-42-5 2662
8 Papaya Approved Phase 2, Phase 3
9
Calcium Approved, Nutraceutical Phase 3,Phase 2 7440-70-2 271
10
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 1406-16-2
11
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3 50-14-6 5280793
12
Candesartan Experimental Phase 3 139481-59-7 2541
13 Hormones Phase 3,Phase 2,Not Applicable
14 calcium channel blockers Phase 3
15 Angiotensin Receptor Antagonists Phase 3
16 Lipid Regulating Agents Phase 3
17 Anticholesteremic Agents Phase 3
18 Angiotensinogen Phase 3
19 Giapreza Phase 3
20 Hypolipidemic Agents Phase 3
21 Calcium, Dietary Phase 3,Phase 2
22 Amlodipine, atorvastatin drug combination Phase 3
23 Antimetabolites Phase 3
24 Angiotensin II Type 1 Receptor Blockers Phase 3
25 Antirheumatic Agents Phase 3
26 Peripheral Nervous System Agents Phase 3
27 Analgesics Phase 3
28 Anti-Inflammatory Agents Phase 3
29 Cyclooxygenase Inhibitors Phase 3
30 Vasodilator Agents Phase 3
31 Analgesics, Non-Narcotic Phase 3
32 Anti-Inflammatory Agents, Non-Steroidal Phase 3
33 Cyclooxygenase 2 Inhibitors Phase 3
34 Tea Phase 2, Phase 3
35 Bone Density Conservation Agents Phase 2, Phase 3
36 Ergocalciferols Phase 2, Phase 3
37 Nutrients Phase 2, Phase 3
38 Trace Elements Phase 2, Phase 3
39 Vitamin D2 Phase 2, Phase 3
40 Micronutrients Phase 2, Phase 3
41 Vitamins Phase 2, Phase 3
42 Calciferol Phase 2, Phase 3
43
Heparin Approved, Investigational 9005-49-6 46507594 772
44
Lidocaine Approved, Vet_approved 137-58-6 3676
45
Spironolactone Approved Not Applicable 1952-01-7, 52-01-7 5833
46
Amiloride Approved Not Applicable 2609-46-3, 2016-88-8 16231
47
Clopidogrel Approved Not Applicable 120202-66-6, 113665-84-2 60606
48 Pharmaceutical Solutions
49 Anesthetics
50 Fibrinolytic Agents

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Unknown status NCT01023373 Phase 4 Medical treatment
2 Renal Stenting With Distal Atheroembolic Protection Unknown status NCT00868972 Phase 2, Phase 3
3 Gadobutrol Enhanced MRA of the Renal Arteries Completed NCT01344460 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
4 Magnevist® Injection-enhanced MRA Compared to Non Contrast MRA for the Detection of Stenosis of the Renal Arteries Completed NCT00310557 Phase 3 Gadopentetate dimeglumine (Magnevist)
5 Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions Completed NCT00081731 Phase 3 Atacand/HCT, Caduet
6 Evaluation of Celecoxib Effects on Amlodipine in Subjects With Existing Hypertension Requiring Antihypertensives Completed NCT02979197 Phase 3 Over-encapsulated 10 mg amlodipine besylate tablet + over-encapsulated 200 mg celecoxib capsule;Over-encapsulated 10 mg amlodipine besylate tablet + matched placebo capsule for over-encapsulated celecoxib capsule;Matched placebo tablet for over-encapsulated amlodipine besylate tablet + matched placebo capsule for over-encapsulated celecoxib capsule
7 Molecular and Clinical Effects of Green Tea and Fermented Papaya Preparation on Diabetes and Cardiovascular Diseases Completed NCT01248143 Phase 2, Phase 3
8 Vitamin-D Receptor Activation (VDRA) in Chronic Kidney Disease Completed NCT01204528 Phase 2, Phase 3 Zemplar
9 Safety and Effectiveness Study of the HERCULINK 14 Stent to Treat Renal Artery Disease Terminated NCT00180544 Phase 3
10 Effect at 6 Months of Renal Denervation in Chronic Heart Failure d'Insuffisance Cardiaque Unknown status NCT02471729 Phase 1, Phase 2
11 Influence of Catheter-based Renal Denervation in Diseases With Increased Sympathetic Activity Recruiting NCT01888315 Phase 1, Phase 2
12 Study to Assess the Effects of Intravenous Bendavia in Patients Undergoing Percutaneous Transluminal Angioplasty of the Renal Artery (PTRA) Terminated NCT01755858 Phase 1, Phase 2 Bendavia;Placebo
13 MSC for Occlusive Disease of the Kidney Completed NCT01840540 Phase 1 Arterial infusion of autologous mesenchymal stem cells
14 MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery Completed NCT00027469 Phase 1
15 Hypoxia and Inflammatory Injury in Human Renovascular Hypertension Active, not recruiting NCT02266394 Phase 1 Mesenchymal stem cell
16 Subcu Administration of CD-NP in Heart Failure Patients With Left Ventricular Assist Device Support Withdrawn NCT03091998 Phase 1 CD-NP
17 Cardiovascular, Renal and Metabolic Profile in Patients With Acute Myocardial Infarction (REN-ACS) Unknown status NCT02388139
18 Vastmanland Myocardial Infarction Study (VaMIS) Completed NCT01452178
19 Clinical Benefits of B-Flow Ultrasound Completed NCT02008097 Not Applicable
20 REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent Completed NCT00631540 Not Applicable
21 Magnetic Resonance Imaging for Evaluating Kidney Function Completed NCT00006173
22 Renal Atherosclerotic Revascularization Evaluation: RAVE Study Completed NCT00127738 Not Applicable
23 The Effects of Amiloride and Spironolactone on Renophysiological and Cardiovascular Variables Completed NCT01195805 Not Applicable Spironolactone;Amiloride
24 Telehealth & Remote Measurement Technologies to Improve Medication Adherence in Hypertension Completed NCT01439256 Not Applicable
25 Cross-sectional Study of Patients With Renal or Craniocervical Fibromuscular Dysplasia Completed NCT02884141
26 Impact of Sympathetic Renal Denervation- a Study in Patients After Renal Transplantation Completed NCT01899456 Not Applicable
27 International First-in-Human Study of the EnligHTN Generation 2 System in Patients With Drug-resistant Uncontrolled Hypertension Completed NCT01836146 Not Applicable
28 A Prospective Danish National Registry of PTRA in Patients With Renovascular Hypertension Recruiting NCT02770066
29 Nephrologic Intervention in Patients Waiting for Cardiac Surgery Recruiting NCT02643745 Not Applicable
30 Evaluation of Patients With Heart Disease Not Eligible for Research Protocols Recruiting NCT00001458
31 Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension Active, not recruiting NCT01673373 Not Applicable
32 IntErnational Long-term Follow-up Study of Patients With Uncontrolled HyperTensioN Active, not recruiting NCT01705080
33 A Feasibility Study to Evaluate the Effect of Concomitant Renal Denervation and Cardiac Ablation on AF Recurrence Active, not recruiting NCT01907828 Not Applicable
34 Endovascular Therapy for Renal Artery Stenosis in China Not yet recruiting NCT03080519 Not Applicable

Search NIH Clinical Center for Renal Artery Disease

Genetic Tests for Renal Artery Disease

Anatomical Context for Renal Artery Disease

MalaCards organs/tissues related to Renal Artery Disease:

42
Kidney, Heart, Bone

Publications for Renal Artery Disease

Articles related to Renal Artery Disease:

(show top 50) (show all 86)
# Title Authors Year
1
Cardiac function response to stenting in atherosclerotic renal artery disease with and without heart failure: results from the Carmel study. ( 30614643 )
2019
2
Combination of Renal Angioplasty and Angiotensin-converting-enzyme Inhibitor Can Reduce Proteinuria in Patients with Bilateral Renal Artery Disease. ( 30799351 )
2019
3
Renovascular heart failure: heart failure in patients with atherosclerotic renal artery disease. ( 27052017 )
2016
4
Our preoccupation with renal artery disease in patients undergoing cardiac surgery: much ado about nothing? ( 24161327 )
2014
5
Ex vivo renal artery reconstruction for complex renal artery disease. ( 24594447 )
2014
6
Prevalence of renal artery disease and its prognostic significance in patients undergoing coronary bypass grafting. ( 25150754 )
2014
7
Long-term follow-up of patients with atherosclerotic renal artery disease. ( 23321402 )
2013
8
Endovascular and open revascularization for nonatherosclerotic renal artery disease. ( 21249718 )
2011
9
MD CT angiography and MR angiography of nonatherosclerotic renal artery disease. ( 21681628 )
2011
10
Vanishing renal artery disease: a segmental arterial mediolysis story. ( 21997510 )
2011
11
Atherosclerotic renal artery disease and heart failure: questions in mind. ( 20466691 )
2010
12
Late outcomes of endovascular and open revascularization for nonatherosclerotic renal artery disease. ( 20855752 )
2010
13
Update on the management of atherosclerotic renal artery disease. ( 19202521 )
2009
14
Atherosclerotic Peripheral Vascular Disease Symposium II: intervention for renal artery disease. ( 19106410 )
2008
15
A multi-center, comparative, phase 3 study to determine the efficacy of gadofosveset-enhanced magnetic resonance angiography for evaluation of renal artery disease. ( 17499952 )
2008
16
Low frequency of renal artery disease in young ischemic stroke patients. ( 18564822 )
2008
17
Relationship between coronary and renal artery disease and associated risk factors in hypertensive and diabetic patients undergoing coronary angiography. ( 19110812 )
2008
18
Novel stent system for accurate placement in aorto-ostial renal artery disease: preclinical study in porcine renal artery model. ( 17574168 )
2007
19
Usefulness of translesional pressure gradient and pharmacological provocation for the assessment of intermediate renal artery disease. ( 16892443 )
2006
20
Clinical insights into the diagnosis and management of atherosclerotic renal artery disease. ( 16901412 )
2006
21
Surgical revascularization for renal artery disease: current status. ( 15720339 )
2005
22
Primary hyperaldosteronism: a frequent cause of residual hypertension after successful endovascular treatment of renal artery disease. ( 16208147 )
2005
23
Factors predicting outcome in a cohort of patients with atherosclerotic renal artery disease diagnosed by magnetic resonance angiography. ( 16310572 )
2005
24
Renal artery disease: diagnosis and management. ( 15029399 )
2004
25
Genetic risk of atherosclerotic renal artery disease: the candidate gene approach in a renal angiography cohort. ( 15326089 )
2004
26
Laparoscopic nephron-sparing surgery in the presence of renal artery disease. ( 14624925 )
2003
27
Atherosclerotic renal artery disease. ( 12472042 )
2002
28
Long-term results of surgical revascularization for renal artery disease. ( 11791498 )
2001
29
Predicting the outcome of invasive treatment of renal artery disease. ( 10672137 )
2000
30
Contemporary management of renal cell carcinoma with coexistent renal artery disease: update of the Cleveland Clinic experience. ( 10962299 )
2000
31
Kidney transplantation from living donors with renal artery disease. ( 11119850 )
2000
32
Prevalence of angiographic atherosclerotic renal artery disease and its relationship to the anatomical extent of peripheral vascular atherosclerosis. ( 10052486 )
1999
33
Renal artery disease in the elderly. ( 10518251 )
1999
34
Revascularization in atherosclerotic renal artery disease. ( 9507232 )
1998
35
Individual kidney function in atherosclerotic renal-artery disease. ( 9568883 )
1998
36
Use of the splenic and hepatic artery for renal revascularization in patients with atherosclerotic renal artery disease. ( 9061145 )
1997
37
Long-term survival after surgical revascularization for atherosclerotic renal artery disease. ( 9186318 )
1997
38
A unique case of renovascular hypertension caused by combined renal artery disease. ( 7584936 )
1995
39
The contemporary role of extra-anatomical surgical renal revascularization in patients with atherosclerotic renal artery disease. ( 7752320 )
1995
40
Surgery for occlusive renal artery disease: immediate and long-term results. ( 7900483 )
1995
41
Defining the role of renal angiography in the diagnosis of renal artery disease. ( 7942828 )
1994
42
The durability of different reconstructive techniques for atherosclerotic renal artery disease. ( 8028093 )
1994
43
Percutaneous angioplasty for atherosclerotic renal artery disease: effect on renal function in azotemic patients. ( 8087830 )
1994
44
Role of duplex ultrasonography in screening for significant renal artery disease. ( 8178389 )
1994
45
Management of atherosclerotic renal artery disease in younger patients. ( 8254782 )
1994
46
Effect of captopril on the renal veno-arterial gradient of erythropoietin and oxygen in unilateral renal artery disease. ( 8140397 )
1993
47
Effect of captopril on renal extraction of renin, angiotensin II, atrial natriuretic peptide and vasopressin, and renal vein renin ratio in patients with arterial hypertension and unilateral renal artery disease. ( 8272217 )
1993
48
Management of renal cell carcinoma with coexistent renal artery disease. ( 8345589 )
1993
49
Fibro-muscular renal artery disease treated by extracorporeal vascular reconstruction and renal autotransplantation: short- and long-term results. ( 1397339 )
1992
50
Angioplasty for the treatment of azotemia and renovascular hypertension in atherosclerotic renal artery disease. ( 1825044 )
1991

Variations for Renal Artery Disease

Expression for Renal Artery Disease

Search GEO for disease gene expression data for Renal Artery Disease.

Pathways for Renal Artery Disease

Pathways related to Renal Artery Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.32 AGTR1 NOS3
2 11.21 NOS3 REN
3 11.13 EPO NOS3 NPPA
4 10.89 EPO NOS3
5 10.64 ACE AGTR1 REN

GO Terms for Renal Artery Disease

Biological processes related to Renal Artery Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.61 EPO NOS3 REN
2 blood vessel remodeling GO:0001974 9.49 ACE NOS3
3 regulation of vasoconstriction GO:0019229 9.48 ACE AGTR1
4 regulation of blood vessel size GO:0050880 9.46 NOS3 NPPA
5 kidney development GO:0001822 9.43 ACE AGTR1 REN
6 amyloid-beta metabolic process GO:0050435 9.4 ACE REN
7 regulation of blood vessel diameter GO:0097746 9.37 ACE AGTR1
8 angiotensin maturation GO:0002003 9.32 ACE REN
9 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.16 ACE AGTR1
10 renin-angiotensin regulation of aldosterone production GO:0002018 8.96 AGTR1 REN
11 regulation of blood pressure GO:0008217 8.92 ACE NOS3 NPPA REN

Molecular functions related to Renal Artery Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.16 EPO NPPA
2 endopeptidase activity GO:0004175 8.96 ACE REN
3 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Renal Artery Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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