MCID: RNL001
MIFTS: 30

Renal Artery Obstruction

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Renal Artery Obstruction

MalaCards integrated aliases for Renal Artery Obstruction:

Name: Renal Artery Obstruction 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2972
ICD10 33 N28.0
MeSH 44 D012078
UMLS 73 C0035066

Summaries for Renal Artery Obstruction

MalaCards based summary : Renal Artery Obstruction is related to anuria and vascular disease. An important gene associated with Renal Artery Obstruction is REN (Renin), and among its related pathways/superpathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and Renin secretion. The drugs Aspirin and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include kidney and heart.

Related Diseases for Renal Artery Obstruction

Diseases related to Renal Artery Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 anuria 29.7 ACE REN
2 vascular disease 28.2 ACE REN SERPINC1
3 hyporeninemic hypoaldosteronism 10.2 ACE REN
4 hypoaldosteronism 10.2 ACE REN
5 hypertensive encephalopathy 10.2 ACE REN
6 hypertensive retinopathy 10.2 ACE REN
7 renal artery disease 10.2 ACE REN
8 hypertension, diastolic 10.2 ACE REN
9 orthostatic proteinuria 10.2 ACE REN
10 atrial septal defect 4 10.2 ACE REN
11 malignant essential hypertension 10.2 ACE REN
12 malignant hypertension 10.2 ACE REN
13 fibromuscular dysplasia 10.2 ACE REN
14 renal hypertension 10.1 ACE REN
15 hepatorenal syndrome 10.1 ACE REN
16 renal tubular dysgenesis 10.1 ACE REN
17 pure autonomic failure 10.1 ACE REN
18 renovascular hypertension 10.1 ACE REN
19 ureteral disease 10.1 ACE REN
20 pseudohyperkalemia, familial, 2, due to red cell leak 10.1 ACE REN
21 interstitial nephritis 10.1 ACE REN
22 microvascular complications of diabetes 3 10.1 ACE REN
23 oligohydramnios 10.1 ACE REN
24 aortic valve disease 1 10.1 ACE REN
25 hypokalemia 10.1 ACE REN
26 polycystic kidney disease 1 with or without polycystic liver disease 10.0 ACE REN
27 renal dysplasia 10.0 ACE REN
28 sleep apnea 10.0 ACE REN
29 glucose metabolism disease 10.0 ACE REN
30 aortic valve disease 2 10.0 ACE REN
31 urinary system disease 10.0 ACE REN
32 intestinal impaction 10.0 REN SERPINC1
33 iga glomerulonephritis 10.0 ACE REN
34 hepatic vascular disease 9.9 REN SERPINC1
35 acquired metabolic disease 9.9 ACE REN
36 congestive heart failure 9.8 ACE REN
37 autosomal dominant polycystic kidney disease 9.8 ACE REN
38 coronary restenosis 9.8 ACE SERPINC1
39 angina pectoris 9.7 ACE SERPINC1
40 cerebrovascular disease 9.7 ACE REN
41 intermediate coronary syndrome 9.7 ACE SERPINC1
42 ischemic optic neuropathy 9.7 ACE SERPINC1
43 intermittent claudication 9.7 ACE SERPINC1
44 nonarteritic anterior ischemic optic neuropathy 9.6 ACE SERPINC1
45 thrombosis 9.6
46 nephrosclerosis 9.6
47 peripheral vascular disease 9.6 ACE SERPINC1
48 chronic kidney failure 9.5 ACE REN
49 immune system disease 9.5 ACE SERPINC1
50 pulmonary edema 9.2 ACE REN SERPINC1

Graphical network of the top 20 diseases related to Renal Artery Obstruction:



Diseases related to Renal Artery Obstruction

Symptoms & Phenotypes for Renal Artery Obstruction

Drugs & Therapeutics for Renal Artery Obstruction

Drugs for Renal Artery Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
3
Ticlopidine Approved Phase 4 55142-85-3 5472
4
Lercanidipine Approved, Investigational Phase 4 100427-26-7 65866
5
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
6
Amlodipine Approved Phase 4,Phase 3 88150-42-9 2162
7
Bisoprolol Approved Phase 4 66722-44-9 2405
8
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
9
Indapamide Approved Phase 4 26807-65-8 3702
10
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
11
Prazosin Approved Phase 4 19216-56-9 4893
12
Rilmenidine Approved, Investigational Phase 4 54187-04-1
13
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
14 Antihypertensive Agents Phase 4,Phase 3
15 Hypoglycemic Agents Phase 4
16 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3
17 Platelet Aggregation Inhibitors Phase 4,Phase 3
18 Pharmaceutical Solutions Phase 4
19 calcium channel blockers Phase 4,Phase 3
20 Calcium, Dietary Phase 4,Phase 3
21 Neurotransmitter Agents Phase 4
22 Purinergic P2 Receptor Antagonists Phase 4
23 Purinergic P2Y Receptor Antagonists Phase 4
24 Antidotes Phase 4
25 Anti-Infective Agents Phase 4,Phase 2
26 Antioxidants Phase 4
27 Antiviral Agents Phase 4
28 Expectorants Phase 4
29 N-monoacetylcystine Phase 4
30 Protective Agents Phase 4
31 Respiratory System Agents Phase 4
32 Atorvastatin Calcium Phase 4,Phase 3 134523-03-8
33
Angiotensin II Approved, Investigational Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
34
Candesartan cilexetil Approved Phase 3 145040-37-5 2540
35
Ginseng Approved, Investigational, Nutraceutical Phase 2, Phase 3 50647-08-0
36
Candesartan Experimental Phase 3 139481-59-7 2541
37 Amlodipine, atorvastatin drug combination Phase 3
38 Angiotensin II Type 1 Receptor Blockers Phase 3
39 Angiotensin Receptor Antagonists Phase 3
40 Angiotensinogen Phase 3
41 Anticholesteremic Agents Phase 3
42 Antimetabolites Phase 3
43 Hypolipidemic Agents Phase 3
44 Lipid Regulating Agents Phase 3
45 Chelating Agents Phase 3
46 Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate Phase 3
47 Angelica Nutraceutical Phase 2, Phase 3
48 Astragalus Nutraceutical Phase 2, Phase 3
49 Chinese Rhubarb Nutraceutical Phase 2, Phase 3
50
Everolimus Approved Phase 2 159351-69-6 6442177

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 Medical and Endovascular Treatment of Atherosclerotic Renal Artery Stenosis (METRAS Study) Unknown status NCT01208714 Phase 4 Optimal medical therapy
2 Comparison of Stenting Versus Best Medical Therapy for Treatment of Ostial Renal Artery Stenosis: a Trial in Patients With Advanced Atherosclerosis Unknown status NCT00711984 Phase 4
3 Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Unknown status NCT01023373 Phase 4 Medical treatment
4 Zainidip in Renal Artery Stenosis Completed NCT02594410 Phase 4 Aspirine;Clopidogrel;Lercanidipine
5 Safety of Low Dose IV Contrast CT Scanning in Chronic Kidney Disease Completed NCT02476526 Phase 4 Low Volume iso-osmolar non-ionic radio contrast medium;Acetylcysteine Inhalation;Sodium Bicarbonate Solution
6 Renal Artery Stenting in Patients With Documented Resistant Hypertension and Atherosclerotic Renal Artery Stenosis (ANDORRA) Terminated NCT02539810 Phase 4 Anti hypertensive, statin and antiplatelet medication.
7 Renal Stenting With Distal Atheroembolic Protection Unknown status NCT00868972 Phase 2, Phase 3
8 The Evaluation Studies of Curative Effect of Fu-zheng-qu-zhuo Oral Liquid in Treatment of Ischemic Nephropathy Unknown status NCT02044835 Phase 2, Phase 3 Fu-zheng-qu-zhuo oral liquid
9 Stenting of Renal Artery Stenosis in Coronary Artery Disease Study Unknown status NCT01173666 Phase 3 Medical therapy
10 Gadobutrol Enhanced MRA of the Renal Arteries Completed NCT01344460 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
11 Stenting in Renal Dysfunction Caused by Atherosclerotic Renal Artery Stenosis Completed NCT00150943 Phase 3
12 Compare Effects of Intensive Versus Conventional Lipid-lowering Therapy in Patients With Severe Atherosclerotic Renal Artery Stenosis Undergoing Stent Placement Completed NCT03521700 Phase 2, Phase 3 Rosuvastatin
13 Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions Completed NCT00081731 Phase 3 Atacand/HCT, Caduet
14 A Safety & Efficacy Clinical Study to Evaluate the Narrowing of the Renal Arteries While Using Gadodiamide Completed NCT00209391 Phase 3 Gadodiamide Injection
15 Comparison of Best Medical Treatment Versus Best Medical Treatment Plus Renal Artery Stenting Completed NCT00640406 Phase 3 Best Medical Treatment
16 Magnevist® Injection-enhanced MRA Compared to Non Contrast MRA for the Detection of Stenosis of the Renal Arteries Completed NCT00310557 Phase 3 Gadopentetate dimeglumine (Magnevist)
17 Safety and Effectiveness Study of the HERCULINK 14 Stent to Treat Renal Artery Disease Terminated NCT00180544 Phase 3
18 Renal Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time Of Flight (TOF) Terminated NCT00845702 Phase 3 Gadoterate meglumine (Dotarem)
19 A Comparison of Coated and Uncoated Stents in Renal Artery Treatment. Completed NCT00235157 Phase 2
20 Prospective Randomized Study Comparing Renal Artery Stenting (RESIST)With/Without Distal Protection Completed NCT00234585 Phase 2
21 Renal Blood Flow Measurement With Positron Emission Tomography (PET) Completed NCT00714142 Phase 2 62Cu-ethylglyoxal bis(thiosemicarbazone);15O-water
22 Ciclosporin A Preconditioning for Renal Artery Stenosis Not yet recruiting NCT03382301 Phase 2 Ciclosporin A preconditioning before renal artery stenosis dilation;NaCl preconditioning before renal artery stenosis dilation
23 Study to Assess the Effects of Intravenous Bendavia in Patients Undergoing Percutaneous Transluminal Angioplasty of the Renal Artery (PTRA) Terminated NCT01755858 Phase 1, Phase 2 Bendavia;Placebo
24 MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery Completed NCT00027469 Phase 1
25 MSC for Occlusive Disease of the Kidney Completed NCT01840540 Phase 1 Arterial infusion of autologous mesenchymal stem cells
26 Hypoxia and Inflammatory Injury in Human Renovascular Hypertension Recruiting NCT02266394 Phase 1 Mesenchymal stem cell
27 Cardiovascular, Renal and Metabolic Profile in Patients With Acute Myocardial Infarction (REN-ACS) Unknown status NCT02388139
28 Hydration Status Assessment Through Body Composition Monitoring in Patients With Acute Myocardial Infarction Unknown status NCT02655341
29 The HERCULES Trial - A Safety and Effectiveness Study of the Herculink Elite Renal Stent to Treat Renal Artery Stenosis Completed NCT00490841 Not Applicable
30 Cohort Follow-up of Patients With Renal or Craniocervical Fibromuscular Dysplasia Completed NCT02961868 Not Applicable
31 Cross-sectional Study of Patients With Renal or Craniocervical Fibromuscular Dysplasia Completed NCT02884141
32 A 15-year Single Center Experience of Endovascular Treatment of Transplant Renal Artery Stenosis Completed NCT03477071
33 Renal Artery Contrast-Free Trial Completed NCT01576835
34 Formula PTX Renal Stent Clinical Study Completed NCT01057316 Not Applicable
35 Prevalence of Renal Artery Stenosis in Patients Referred for Cardiac Catheterization Completed NCT00885768
36 REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent Completed NCT00631540 Not Applicable
37 Renal Arteries Dysplastic Aneurysms: Anatomopathological and Genetic Study Completed NCT02528149
38 Renal Fractional Flow Reserve in Renal Artery Stenting Completed NCT01128933 Not Applicable
39 Evaluation of Patients With Known or Suspected Heart Disease Completed NCT00001313
40 On-table Renal Perfusion Evaluation for Patients With Renal Artery Stenosis or Aortic Dissection With Renal Artery Obstruction Recruiting NCT03530748
41 A Prospective Danish National Registry of PTRA in Patients With Renovascular Hypertension Recruiting NCT02770066
42 A Study of Using Parenchymal Blood Volume(PBV) for Endovascular Treatment of Renal Arterial Stenosis Recruiting NCT03252639
43 Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension Active, not recruiting NCT01673373 Not Applicable
44 Endovascular Therapy for Renal Artery Stenosis in China Not yet recruiting NCT03080519 Not Applicable

Search NIH Clinical Center for Renal Artery Obstruction

Cochrane evidence based reviews: renal artery obstruction

Genetic Tests for Renal Artery Obstruction

Anatomical Context for Renal Artery Obstruction

MalaCards organs/tissues related to Renal Artery Obstruction:

41
Kidney, Heart

Publications for Renal Artery Obstruction

Articles related to Renal Artery Obstruction:

(show all 14)
# Title Authors Year
1
Functional renal artery obstruction following percutaneous kidney biopsy. ( 15840676 )
2005
2
Balloon angioplasty versus medical therapy for hypertensive patients with renal artery obstruction. ( 12917937 )
2003
3
[Renal artery obstruction: from experimental models to logical approach to diagnosis and treatment]. ( 8763013 )
1996
4
Renal artery obstruction. ( 3994091 )
1985
5
Anuria secondary to renal artery obstruction in a solitary kidney: 9-year followup. ( 712908 )
1978
6
Hypertension due to renal artery obstruction in Eskimo girl: case of primary arteritis of aorta. ( 5849147 )
1965
7
OCCLUSIVE VASCULAR DISEASE INCLUDING RENAL ARTERY OBSTRUCTION--TREATMENT AND PROGNOSIS. ( 15446155 )
1964
8
RECURRENT HYPERTENSION IN A PATIENT WITH CHRONIC AORTOILIAC THROMBOSIS AND RENAL ARTERY OBSTRUCTION SUCCESSFULLY TREATED ON TWO OCCASIONS BY PARTIAL NEPHRECTOMY. ( 14104845 )
1964
9
SEPARATE RENAL FUNCTION STUDIES IN DOGS WITH CHRONIC UNILATERAL RENAL ARTERY OBSTRUCTION. THE EFFECT OF HYPERTONIC UREA INFUSIONS. ( 14089529 )
1963
10
RENAL ARTERY OBSTRUCTION. ( 14063045 )
1963
11
Remediable hypertension due to renal artery obstruction. ( 14017909 )
1962
12
Ureteric irregularity with renal artery obstruction. A new radiological sign. ( 13776533 )
1961
13
Modification of the "Howard test" for the detection of renal-artery obstruction. ( 13739575 )
1960
14
Unilateral renal artery obstruction associated with malignant nephrosclerosis confined to the opposite kidney. ( 12976348 )
1952

Variations for Renal Artery Obstruction

Expression for Renal Artery Obstruction

Search GEO for disease gene expression data for Renal Artery Obstruction.

Pathways for Renal Artery Obstruction

Pathways related to Renal Artery Obstruction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.86 ACE REN
2 10.44 ACE REN

GO Terms for Renal Artery Obstruction

Cellular components related to Renal Artery Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 ACE JCHAIN REN SERPINC1
2 extracellular space GO:0005615 9.02 ACE DPT JCHAIN REN SERPINC1

Biological processes related to Renal Artery Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.26 ACE REN
2 regulation of blood pressure GO:0008217 9.16 ACE REN
3 amyloid-beta metabolic process GO:0050435 8.96 ACE REN
4 angiotensin maturation GO:0002003 8.62 ACE REN

Molecular functions related to Renal Artery Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 ACE REN

Sources for Renal Artery Obstruction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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