Renal Artery Obstruction

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Renal Artery Obstruction

MalaCards integrated aliases for Renal Artery Obstruction:

Name: Renal Artery Obstruction 12 44 15 17 72


External Ids:

Disease Ontology 12 DOID:2972
MeSH 44 D012078
ICD10 33 N28.0
UMLS 72 C0035066

Summaries for Renal Artery Obstruction

MalaCards based summary : Renal Artery Obstruction is related to anuria and renovascular hypertension. An important gene associated with Renal Artery Obstruction is REN (Renin), and among its related pathways/superpathways are Peptide hormone metabolism and Renin secretion. The drugs Ticlopidine and Lercanidipine have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and testes, and related phenotypes are hematopoietic system and immune system

Related Diseases for Renal Artery Obstruction

Diseases related to Renal Artery Obstruction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 anuria 30.0 REN ACE
2 renovascular hypertension 29.9 REN ACE
3 vascular disease 28.6 SERPINC1 REN ACE
4 hypoaldosteronism 10.1 REN ACE
5 hypertensive encephalopathy 10.1 REN ACE
6 hypertension, diastolic 10.1 REN ACE
7 renal artery disease 10.1 REN ACE
8 hypertensive retinopathy 10.1 REN ACE
9 orthostatic proteinuria 10.1 REN ACE
10 malignant essential hypertension 10.1 REN ACE
11 malignant hypertension 10.1 REN ACE
12 hepatorenal syndrome 10.1 REN ACE
13 fibromuscular dysplasia 10.1 REN ACE
14 renal hypertension 10.0 REN ACE
15 pure autonomic failure 10.0 REN ACE
16 renal tubular dysgenesis 10.0 REN ACE
17 pseudohyperkalemia, familial, 2, due to red cell leak 10.0 REN ACE
18 interstitial nephritis 10.0 REN ACE
19 heart valve disease 10.0 REN ACE
20 obstructive nephropathy 10.0 REN ACE
21 oligohydramnios 10.0 REN ACE
22 hypokalemia 10.0 REN ACE
23 carotid artery disease 10.0 REN ACE
24 pulmonary edema 10.0 REN ACE
25 renal dysplasia 10.0 REN ACE
26 iga glomerulonephritis 10.0 REN ACE
27 aortic valve disease 2 10.0 REN ACE
28 sleep apnea 9.9 REN ACE
29 glucose metabolism disease 9.9 REN ACE
30 intestinal impaction 9.9 SERPINC1 REN
31 urinary system disease 9.9 REN ACE
32 acquired metabolic disease 9.9 REN ACE
33 aortic valve disease 1 9.9 REN ACE
34 hepatic vascular disease 9.9 SERPINC1 REN
35 congestive heart failure 9.8 REN ACE
36 autosomal dominant polycystic kidney disease 9.8 REN ACE
37 polycystic kidney disease 9.8 REN ACE
38 coronary restenosis 9.8 SERPINC1 ACE
39 intermediate coronary syndrome 9.8 SERPINC1 ACE
40 retinal artery occlusion 9.8 SERPINC1 ACE
41 nephrosclerosis 9.8
42 aortic aneurysm 9.8
43 uremia 9.8
44 48,xyyy 9.8
45 cerebrovascular disease 9.8 REN ACE
46 angina pectoris 9.8 SERPINC1 ACE
47 intermittent claudication 9.7 SERPINC1 ACE
48 nonarteritic anterior ischemic optic neuropathy 9.7 SERPINC1 ACE
49 eclampsia 9.7 SERPINC1 REN
50 peripheral vascular disease 9.7 SERPINC1 ACE

Graphical network of the top 20 diseases related to Renal Artery Obstruction:

Diseases related to Renal Artery Obstruction

Symptoms & Phenotypes for Renal Artery Obstruction

MGI Mouse Phenotypes related to Renal Artery Obstruction:

# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.26 ACE JCHAIN REN SERPINC1
2 immune system MP:0005387 8.92 ACE JCHAIN REN SERPINC1

Drugs & Therapeutics for Renal Artery Obstruction

Drugs for Renal Artery Obstruction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Ticlopidine Approved Phase 4 55142-85-3 5472
Lercanidipine Approved, Investigational Phase 4 100427-26-7 65866
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
Amlodipine Approved Phase 4 88150-42-9 2162
Rilmenidine Approved, Investigational Phase 4 54187-04-1
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
Prazosin Approved Phase 4 19216-56-9 4893
Bisoprolol Approved Phase 4 66722-44-9 2405
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
Indapamide Approved Phase 4 26807-65-8 3702
Atorvastatin Approved Phase 4 134523-00-5 60823
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
16 Hypoglycemic Agents Phase 4
17 Neurotransmitter Agents Phase 4
18 Hormones Phase 4
19 Purinergic P2 Receptor Antagonists Phase 4
20 Purinergic P2Y Receptor Antagonists Phase 4
21 Platelet Aggregation Inhibitors Phase 4
22 calcium channel blockers Phase 4
23 Calcium, Dietary Phase 4
24 Pharmaceutical Solutions Phase 4
25 Respiratory System Agents Phase 4
26 Free Radical Scavengers Phase 4
27 Antidotes Phase 4
28 Antioxidants Phase 4
29 N-monoacetylcystine Phase 4
30 Protective Agents Phase 4
31 Expectorants Phase 4
32 Antiviral Agents Phase 4
33 Antihypertensive Agents Phase 4
34 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
Angiotensin II Approved, Investigational Phase 3 11128-99-7, 68521-88-0, 4474-91-3 172198
Candesartan cilexetil Approved Phase 3 145040-37-5 2540
Ginseng Approved, Investigational, Nutraceutical Phase 2, Phase 3 50647-08-0
Candesartan Experimental Phase 3 139481-59-7 2541
39 Angelica Phase 2, Phase 3
40 Chinese Rhubarb Phase 2, Phase 3
41 Astragalus Phase 2, Phase 3
42 Angiotensin Receptor Antagonists Phase 3
43 Anticholesteremic Agents Phase 2, Phase 3
44 Rosuvastatin Calcium Phase 2, Phase 3 147098-20-2
45 Lipid Regulating Agents Phase 2, Phase 3
46 Hypolipidemic Agents Phase 2, Phase 3
47 Antimetabolites Phase 2, Phase 3
48 Angiotensinogen Phase 3
49 Angiotensin II Type 1 Receptor Blockers Phase 3
50 Giapreza Phase 3

Interventional clinical trials:

(show all 45)
# Name Status NCT ID Phase Drugs
1 Comparison of Stenting Versus Best Medical Therapy for Treatment of Ostial Renal Artery Stenosis: a Randomized Controlled Trial in Patients With Advanced Atherosclerosis. Unknown status NCT00711984 Phase 4
2 Phase 4 Study of Medical Therapy Versus Medical Therapy Plus Renal Artery Stenting in Preventing the Progression of Renal Failure in Atherosclerotic Renovascular Disease Unknown status NCT01023373 Phase 4 Medical treatment
3 Endovascular Treatment Versus Optimal Medical Treatment of Atherosclerotic Renal Artery for Preserving Renal Function of the Ischemic Kidney. Unknown status NCT01208714 Phase 4 Optimal medical therapy
4 The Efficacy of Renal Artery Stent Combined With Standardized Medical Therapy in Patients With Atherosclerotic Renal Artery Stenosis Completed NCT02594410 Phase 4 Aspirine;Clopidogrel;Lercanidipine
5 Safety of Low Dose Intravenous Contrast 64 Multi-Detector Computed Tomography Scanning in Patients With Chronic Kidney Disease Completed NCT02476526 Phase 4 Low Volume iso-osmolar non-ionic radio contrast medium;Acetylcysteine Inhalation;Sodium Bicarbonate Solution
6 Optimum and Stepped Care Standardised Antihypertensive Treatment With or Without Renal Artery Stenting in Patients With Documented Resistant Hypertension and Atherosclerotic Renal Artery Stenosis. ANDORRA TRIAL Terminated NCT02539810 Phase 4 Anti hypertensive, statin and antiplatelet medication.
7 The Evaluation Studies of Curative Effect of Fu-zheng-qu-zhuo Oral Liquid in Treatment of Ischemic Nephropathy Unknown status NCT02044835 Phase 2, Phase 3 Fu-zheng-qu-zhuo oral liquid
8 Percutaneous Renal Stenting in Renovascular Disease With or Without Distal Atheroembolic Protection Unknown status NCT00868972 Phase 2, Phase 3
9 Renal Artery Stenosis in Coronary Artery Disease: Medical Therapy Versus Medical Therapy Plus Renal Artery Stenting in Preventing Cardiac and Renal Outcomes. The Rationale and Study Design of a Prospective,Randomized Trial: the RASCAD Study Unknown status NCT01173666 Phase 3 Medical therapy
10 A Prospective, Randomized Trial to Compare Effects of Intensive Versus Conventional Lipid-lowering Therapy in Patients With Severe Atherosclerotic Renal Artery Stenosis Undergoing Stent Placement Completed NCT03521700 Phase 2, Phase 3 Rosuvastatin
11 Multicenter, Open-label Study to Evaluate the Safety and Efficacy (by Blinded Reading) of Gadobutrol-enhanced Magnetic Resonance Angiography (MRA) After a Single Injection of 0.1 mmol/kg of Gadobutrol in Subjects With Known or Suspected Renal Artery Disease Completed NCT01344460 Phase 3 Gadobutrol (Gadovist, BAY86-4875)
12 A Randomized, Multi-centre, Prospective Study Comparing Best Medical Treatment Versus Best Medical Treatment Plus Renal Artery Stenting in Patients With Hemodynamically Relevant Atherosclerotic Renal Artery Stenosis Completed NCT00640406 Phase 3 Best Medical Treatment
13 A Multicentre, Phase 3, Open-Label, Controlled Study Evaluating the Efficacy and Safety of 0.1 mmol/kg OMNISCAN (Gadodiamide Injection) in Magnetic Resonance Angiography (MRA) of the Renal Arteries Completed NCT00209391 Phase 3 Gadodiamide Injection
14 Multicenter, Open-label Study of the Safety (Open-label) and Efficacy (Open-label and Blinded Reader) of a Single Administration of Approximately 0.1 mmol/kg of Magnevist® Injection-enhanced Magnetic Resonance Arteriography (MRA) and 2-dimensional-time-of-flight (2D-TOF) MRA in Patients With Known or Suspected Renal Artery Disease Undergoing MRA of the Renal Arteries With Intra-arterial Digital Subtraction Arteriography (i.a. DSA) as the Standard of Reference Completed NCT00310557 Phase 3 Gadopentetate dimeglumine (Magnevist)
15 Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) Completed NCT00081731 Phase 3 Atacand/HCT, Caduet
16 Evaluation of Dotarem-enhanced Magnetic Resonance Angiography (MRA) Compared to Time-Of-Flight (TOF) MRA in the Diagnosis of Renal Arterial Disease Terminated NCT00845702 Phase 3 Gadoterate meglumine (Dotarem)
17 A Prospective, Non-Randomized, Multicenter, Single-Arm, Clinical Trial to Assess the Safety and Efficacy of the RX HERCULINK 14 Peripheral Stent System for Treatment in de Novo or Restenotic Renal Artery Stenosis Terminated NCT00180544 Phase 3
18 Renal Blood Flow Measurement With PET Completed NCT00714142 Phase 2 62Cu-ethylglyoxal bis(thiosemicarbazone);15O-water
19 Palmaz Genesis Peripheral Stainless Steel Balloon Expandable Stent, Comparing a Sirolimus Coated Versus an Uncoated Stent in REnal Artery Treatment. Completed NCT00235157 Phase 2
20 A Prospective Randomized Multicenter Study Comparing the Safety and Efficacy of Renal Artery Stenting With/Without Distal Protection Device (AngioGuard) and With/Without the Use of a Platelet Aggregator Inhibitor (Abciximab-Reopro) (RESIST) Completed NCT00234585 Phase 2
21 Impact of a Ciclosporin A Preconditioning for Prevention of Ischemia-reperfusion Injury After Renal Artery Stenosis Dilation Recruiting NCT03382301 Phase 2 Ciclosporin A preconditioning before renal artery stenosis dilation;NaCl preconditioning before renal artery stenosis dilation
22 A Phase 2a, Randomized, Placebo-controlled, Single Center Trial to Evaluate the Impact of Intravenous Bendavia™ (MTP-131) on Ischemia Reperfusion Injury in Atherosclerotic Renal Artery Stenosis in Patients Undergoing Percutaneous Transluminal Angioplasty of the Renal Artery (PTRA) Terminated NCT01755858 Phase 1, Phase 2 Bendavia;Placebo
23 Phase I Study of Autologous Mesenchymal Stem Cells in the Treatment of Atherosclerotic Renal Artery Stenosis Completed NCT01840540 Phase 1 Arterial infusion of autologous mesenchymal stem cells
24 Hypoxia and Inflammatory Injury in Human Renovascular Hypertension : Phase 1 Trial of Mesenchymal Stem Cell Therapy Active, not recruiting NCT02266394 Phase 1 Mesenchymal stem cell
25 FiberNet Renal Artery Embolic Protection Study: A Prospective, Single-arm Feasibility Trial of Renal Artery Distal Protection Using the Lumen Biomedical FiberNet Embolic Protection System Unknown status NCT00674505
26 A Prospective Study of Using Parenchymal Blood Volume(PBV) for Endovascular Treatment of Renal Arterial Stenosis Unknown status NCT03252639
27 Cardiovascular, Renal and Metabolic Profile in Patients With Acute Myocardial Infarction (AMI) Included in the Romanian National Programme of Primary Percutaneous Revascularisation - a Single Center Observational Study Unknown status NCT02388139
28 Hydration Status Assessment Through Body Composition Monitoring And Renal Artery Stenosis Evaluation in Patients With Acute Myocardial Infarction Referred For Primary PCI Unknown status NCT02655341
29 Prognostic Value of Renal Fractional Flow Reserve in Hypertensive Patients With Renal Artery Stenosis Qualified to Renal Artery Stenting Completed NCT01128933
30 REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent Completed NCT00631540
31 A Clinical Trial to Assess the Safety and Efficacy of the RX Herculink(R) Elite(TM) Renal Stent System for the Treatment of Suboptimal Post-procedural Percutaneous Transluminal Angioplasty (PTA) in de Novo or Restenotic Renal Artery Stenoses in Patients With Uncontrolled Hypertension. Completed NCT00490841
32 Evaluation of Safety and Effectiveness of the Formula PTX Balloon-Expandable Stent for Renal Artery Stenosis Completed NCT01057316
33 Prevalence of Renal Artery Stenosis in Patients Refered for Cardiac Catheterization to Heart Center Hospital in July-September 2008 Completed NCT00885768
34 Evaluation of Patients With Known or Suspected Heart Disease (Screening Protocol) Completed NCT00001313
35 A 15-year Single Center Experience of Endovascular Treatment of Transplant Renal Artery Stenosis: Evaluation of Post-operative Outcomes Completed NCT03477071
36 Renal Arteries Dysplastic Aneurysms: Anatomopathological and Genetic Study Completed NCT02528149
37 Comparison of Non-contrast Renal Artery Magnetic Resonance Angiography With Contrast-enhanced CT Angiography Completed NCT01576835
38 PROgression of FIbromuscular LEsions Completed NCT02961868
39 Assessment of Renal and Cervical Artery DysplasIA Completed NCT02884141
40 A Prospective Danish National Registry of Percutaneous Transluminal Renal Angioplasty in Patients With Renovascular Hypertension Recruiting NCT02770066
41 To Asses Hemodynamic Disturbances to the Ostia of the Renal Arteries Generated by the Implantation of EVAR With a Suprarenal Fixation Recruiting NCT03594786
42 On-table Renal Perfusion Evaluation for Patients With Renal Artery Stenosis or Aortic Dissection With Renal Artery Obstruction Recruiting NCT03530748
43 ARTISAN: iCAST™ RX De Novo Stent Placement for the Treatment of Atherosclerotic Renal Artery Stenosis in Patients With Resistant Hypertension Active, not recruiting NCT01673373
44 A Multicenter Registry of Endovascular Therapy for Renal Artery Stenosis in China Not yet recruiting NCT03080519
45 Ultrasound Wave Therapy for Post-stenotic Microvascular Remodeling Not yet recruiting NCT03914157

Search NIH Clinical Center for Renal Artery Obstruction

Cochrane evidence based reviews: renal artery obstruction

Genetic Tests for Renal Artery Obstruction

Anatomical Context for Renal Artery Obstruction

MalaCards organs/tissues related to Renal Artery Obstruction:

Kidney, Heart, Testes

Publications for Renal Artery Obstruction

Articles related to Renal Artery Obstruction:

(show top 50) (show all 61)
# Title Authors PMID Year
Treatment of a recurrent renal artery stenosis and stent fracture using a drug eluting stent in a pediatric patient. 38
28509158 2016
Renovascular acute renal failure precipitated by extracorporeal shock wave lithotripsy for pancreatic stones. 38
26251710 2015
Mechanism of stent failure in a patient with fibromuscular dysplasia following renal artery stenting. 38
25192822 2015
Postoperative "Chimney" for Unintentional Renal Artery Occlusion after EVAR. 38
25478283 2014
Aortic intussusception complicating diagnostic angiography: recognition and management. 38
23608257 2013
Takayasu disease revealed by bilateral loss of vision. 38
25391067 2009
A single-center experience treating renal malperfusion after aortic dissection with central aortic fenestration and renal artery stenting. 38
18455638 2008
Prevalence of renal artery stenosis in 1,656 patients who have undergone cardiac catheterization. 38
17057922 2006
Functional renal artery obstruction following percutaneous kidney biopsy. 38
15840676 2005
Renovascular hypertension due to antithrombin deficiency in childhood. 38
15338392 2004
Clinical insights into the diagnosis and management of renovascular disease. An evidence-based review. 38
15467512 2004
The diagnosis and management of renovascular disease: a primary care perspective. Part I. Making the diagnosis. 38
12826784 2003
Balloon angioplasty versus medical therapy for hypertensive patients with renal artery obstruction. 38
12917937 2003
An evidence-based approach to diagnosing renovascular hypertension. 38
11602079 2001
Renal artery disease in the elderly. 38
10518251 1999
Ischemic disease of the kidney: how and why to consider revascularization. 38
9650120 1998
Acute bilateral renal artery occlusion due to granulomatous and necrotizing vasculitis. 38
9509569 1998
Renovascular hypertension with low-to-normal plasma renin: clinical and angiographic features. 38
9486089 1997
[The successful percutaneous revascularization of a subacute renal artery obstruction]. 38
9156604 1997
[Renal artery obstruction: from experimental models to logical approach to diagnosis and treatment]. 38
8763013 1996
Long-term immunosuppressive treatment of a child with Takayasu's arteritis and high IgE immunoglobulins. 38
8611360 1996
Options for therapy of ischemic nephropathy: role of angioplasty and surgery. 38
8720086 1996
Excess prevalence of supraaortic artery lesions in renovascular hypertension: an arteriographic study. 38
7820835 1994
Labeled lectin studies of renal tubular dysgenesis and renal tubular atrophy of postnatal renal ischemia and end-stage kidney disease. 38
8159624 1994
[Color-Doppler and angioplasty in renovascular hypertension]. 38
8332815 1993
Acute non-traumatic obstructions of the renal artery. 38
1572872 1992
[Complete anuria in unilateral renal artery obstruction and ischemic nephropathy]. 38
1879329 1991
[The isolation of the contribution of the parenchyma to the radionephrogram and the assessment of kidney purifying function]. 38
2374481 1990
I-131-orthoiodohippurate renal function test in detection of renal artery occlusion in aortic dissection. 38
2168248 1990
Increased hematocrit mitigates ischemic renal damage in the splenectomized dog. 38
2923139 1989
Myoglobinuria exacerbates ischemic renal damage in the dog. 38
2797346 1989
Thrombosis of the renal artery of a small, solitary kidney: successful return of renal function after prolonged anuria. 38
15227264 1988
Reversal of renal failure after revascularization in atheromatous renovascular disease. Report of two cases. 38
3218663 1988
Renal artery obstruction. 38
3994091 1985
[Regional lytic therapy of acute renal artery obstruction]. 38
6697931 1984
Renovascular hypertension in black patients. 38
7040233 1982
Successful revascularization of early posttransplant renal arterial occlusion. 38
7036393 1982
Renal subcapsular rim sign: new etiologies and pathogenesis. 38
6976711 1982
Anuria secondary to renal artery obstruction in a solitary kidney: 9-year followup. 38
712908 1978
Emergency uroradiology for the nontraumatized patient. 38
684204 1978
Revascularization of the ischemic kidney. 38
626586 1978
[Collateral circulation through uretral arteries caused by chronical central renal artery obstruction (author's transl)]. 38
625855 1978
[Pheochromocytoma with scalloping of the ureter (author's transl)]. 38
1273304 1976
Thoracic aorta-to-femoral artery by-pass. For the treatment of complete obstruction of the abdominal aorta at the level of the renal arteries. 38
1184674 1975
[Proceedings: Case of left renal artery obstruction caused by an extensive dissecting aortic aneurysm]. 38
1121064 1975
[Reconstructive surgery in threatening uremia due to renal artery obstruction]. 38
1123938 1975
[Non-traumatic acute renal artery obstruction]. 38
4272781 1973
Renin in hypertension: how important as a risk factor? 38
4355135 1973
[Embolic renal artery obstruction]. 38
4542379 1973
[Case of juvenile hypertension associated with abnormal course of the abdominal artery and bilateral renal artery obstruction]. 38
5358690 1969

Variations for Renal Artery Obstruction

Expression for Renal Artery Obstruction

Search GEO for disease gene expression data for Renal Artery Obstruction.

Pathways for Renal Artery Obstruction

Pathways related to Renal Artery Obstruction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
11.22 REN ACE
2 10.46 REN ACE

GO Terms for Renal Artery Obstruction

Cellular components related to Renal Artery Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 SERPINC1 REN JCHAIN ACE
2 blood microparticle GO:0072562 9.16 SERPINC1 JCHAIN
3 extracellular space GO:0005615 8.92 SERPINC1 REN JCHAIN ACE

Biological processes related to Renal Artery Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.26 REN ACE
2 regulation of blood pressure GO:0008217 9.16 REN ACE
3 amyloid-beta metabolic process GO:0050435 8.96 REN ACE
4 angiotensin maturation GO:0002003 8.62 REN ACE

Molecular functions related to Renal Artery Obstruction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 REN ACE

Sources for Renal Artery Obstruction

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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