RFH1
MCID: RNL113
MIFTS: 31

Renal Failure, Progressive, with Hypertension (RFH1)

Categories: Cardiovascular diseases, Ear diseases, Genetic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Renal Failure, Progressive, with Hypertension

MalaCards integrated aliases for Renal Failure, Progressive, with Hypertension:

Name: Renal Failure, Progressive, with Hypertension 57 70
Nephropathy-Hypertension 57 13
Autosomal Dominant Progressive Nephropathy with Hypertension 58
Nephritis, Familial, Without Deafness or Ocular Defect 57
Renal Failure, Adult-Onset; Aorf 57
Renal Failure, Adult-Onset 57
Hypertensive Nephropathy 70
Nephropathy, Familial 57
Rfh1 57
Aorf 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant

Miscellaneous:
progressive disorder
onset in young adulthood or adulthood
hypertension is presenting sign
one family has been reported (last curated december 2012)


HPO:

31
renal failure, progressive, with hypertension:
Inheritance autosomal dominant inheritance
Onset and clinical course progressive adult onset


Classifications:

Orphanet: 58  
Rare circulatory system diseases
Rare renal diseases


External Ids:

OMIM® 57 161900
ICD10 via Orphanet 33 I15.1
Orphanet 58 ORPHA88659
MedGen 41 C0403443
UMLS 70 C0403443 C0848548

Summaries for Renal Failure, Progressive, with Hypertension

MalaCards based summary : Renal Failure, Progressive, with Hypertension, also known as nephropathy-hypertension, is related to tubulointerstitial kidney disease, autosomal dominant, 1 and tubulointerstitial kidney disease, autosomal dominant, 4. An important gene associated with Renal Failure, Progressive, with Hypertension is RFH1 (Renal Failure, Progressive, With Hypertension). The drugs Angiotensin II and Lactitol have been mentioned in the context of this disorder. Affiliated tissues include kidney and endothelial, and related phenotypes are hypertension and proteinuria

More information from OMIM: 161900

Related Diseases for Renal Failure, Progressive, with Hypertension

Graphical network of the top 20 diseases related to Renal Failure, Progressive, with Hypertension:



Diseases related to Renal Failure, Progressive, with Hypertension

Symptoms & Phenotypes for Renal Failure, Progressive, with Hypertension

Human phenotypes related to Renal Failure, Progressive, with Hypertension:

31 (show all 7)
# Description HPO Frequency HPO Source Accession
1 hypertension 31 HP:0000822
2 proteinuria 31 HP:0000093
3 renal insufficiency 31 HP:0000083
4 stage 5 chronic kidney disease 31 HP:0003774
5 microscopic hematuria 31 HP:0002907
6 elevated serum creatinine 31 HP:0003259
7 nephritis 31 HP:0000123

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Cardiovascular Vascular:
hypertension

Genitourinary Kidneys:
renal failure, progressive
end-stage renal disease
renal biopsy showed interstitial fibrosis
some sclerotic glomeruli
no complement deposition

Laboratory Abnormalities:
increased serum creatinine
no proteinuria

Clinical features from OMIM®:

161900 (Updated 05-Apr-2021)

Drugs & Therapeutics for Renal Failure, Progressive, with Hypertension

Drugs for Renal Failure, Progressive, with Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198
2
Lactitol Approved, Investigational Phase 4 585-86-4 157355
3
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
4
Losartan Approved Phase 4 114798-26-4 3961
5 Giapreza Phase 4
6 Angiotensinogen Phase 4
7 Angiotensin Receptor Antagonists Phase 4
8 Antihypertensive Agents Phase 4
9 Angiotensin II Type 1 Receptor Blockers Phase 4
10 Anti-Arrhythmia Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Nighttime Valsartan on Prognosis of Nocturnal Hypertension Patients Undergoing Maintenance Hemodialysis Not yet recruiting NCT03594825 Phase 4 Valsartan
2 Effect of Nighttime Losartan on Prognosis of Nocturnal Hypertension Patients Undergoing Continous Ambulatory Peritoneal Dialysis Not yet recruiting NCT03692013 Phase 4 Losartan
3 Effects of Nocturnal Hypertension on Sleep Quality in Renal Transplant Recipients Unknown status NCT03651492
4 Effectiveness of Implementation of a Patient-centered Self-management Program in Patients With Hypertensive Nephropathy Recruiting NCT04633993
5 Whole Exome Sequencing Analysis Project in Chronic Kidney Disease Patients With Nocturnal Hypertension Recruiting NCT03718585

Search NIH Clinical Center for Renal Failure, Progressive, with Hypertension

Genetic Tests for Renal Failure, Progressive, with Hypertension

Anatomical Context for Renal Failure, Progressive, with Hypertension

MalaCards organs/tissues related to Renal Failure, Progressive, with Hypertension:

40
Kidney, Endothelial

Publications for Renal Failure, Progressive, with Hypertension

Articles related to Renal Failure, Progressive, with Hypertension:

(show top 50) (show all 85)
# Title Authors PMID Year
1
A locus for an autosomal dominant form of progressive renal failure and hypertension at chromosome 1q21. 57
10930359 2000
2
Functional deletion mutation of the 5'-flanking region of type A human natriuretic peptide receptor gene and its association with essential hypertension and left ventricular hypertrophy in the Japanese. 57
10785505 2000
3
Familial interstitial nephritis. 57
7296967 1981
4
In-vivo activation of complement in hereditary nephropathy. 57
4124530 1973
5
A family showing hereditary nephropathy. 57
5132064 1971
6
Familial nephritis associated with the nephrotic syndrome. In a family with severe involvement in females. 57
5763827 1969
7
Hereditary nephropathy without deafness. 57
4951535 1967
8
The hereditary renal diseases. 57
5338472 1967
9
Familial nephritis. 57
6030413 1967
10
Congenital hereditary hematuria. 57
13194078 1954
11
Associations of TP53 codon 72 polymorphism with complications and comorbidities in patients with type 1 diabetes. 61
33495869 2021
12
Proteomics-Based Machine Learning Approach as an Alternative to Conventional Biomarkers for Differential Diagnosis of Chronic Kidney Diseases. 61
32645927 2020
13
Comprehensive assessment of mitochondrial respiratory function in freshly isolated nephron segments. 61
32223308 2020
14
The correlation between blood oxidative stress and sialic acid content in diabetic patients with nephropathy, hypertension, and hyperlipidemia. 61
31950000 2020
15
No association of SNP 313A→G in GSTP1 with nephropathy, hypertension and dyslipidemia in type 2 diabetes mellitus. 61
30883298 2019
16
Biomarkers for individualized dosage adjustments in immunosuppressive therapy using calcineurin inhibitors after organ transplantation. 61
29950613 2019
17
The Role of Uric Acid in Acute Kidney Injury. 61
30991383 2019
18
Neurons and Microglia; A Sickly-Sweet Duo in Diabetic Pain Neuropathy. 61
30766472 2019
19
Higher Incidence of Renal Allograft Glomerulonephritis in Living-Related Donor Kidney Transplantation. 61
30316370 2018
20
Role of variants rs5030717 and rs5030718 of TLR4 in the risk prediction of nephropathy, hypertension and dyslipidaemia in type 2 diabetes mellitus. 61
30211669 2018
21
Analysis of the risk factors for contrast-induced nephropathy in over-aged patients receiving coronary intervention. 61
30299175 2018
22
Cadmium treatment induces echinocytosis, DNA damage, inflammation, and apoptosis in cardiac tissue of albino Wistar rats. 61
29524682 2018
23
A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress. 61
28325753 2017
24
Nonconcordant regulation of mitochondrial respiratory complexes in the kidneys of 5/6 nephrectomized mice. 61
28954992 2017
25
Patiromer: The First Potassium Binder Approved in Over 50 Years. 61
27548687 2016
26
To Stent or Not to Stent? Update on Revascularization for Atherosclerotic Renovascular Disease. 61
27130448 2016
27
Protective effects of saffron (its active constituent, crocin) on nephropathy in streptozotocin-induced diabetic rats. 61
24925368 2015
28
Prevalence of micro and macrovascular complications and their risk factors in type-2 diabetes mellitus. 61
25856915 2014
29
Semantic Modeling for SNPs Associated with Ethnic Disparities in HapMap Samples. 61
24748859 2014
30
Renal artery stenosis: epidemiology and treatment. 61
24868169 2014
31
Laser therapy in metabolic syndrome-related kidney injury. 61
23360312 2013
32
MicroRNAs in kidney disease: an emerging understanding. 61
23219107 2013
33
Protective role of the vitamin D receptor. 61
23246677 2012
34
Risk factors associated with cognitive decline in the elderly with type 2 diabetes: baseline data analysis of the Japanese Elderly Diabetes Intervention Trial. 61
22435945 2012
35
Incidence, risk factors for amputation among patients with diabetic foot ulcer in a North Indian tertiary care hospital. 61
22079404 2012
36
Influence of birth weight on the renal development and kidney diseases in adulthood: experimental and clinical evidence. 61
22778952 2012
37
Early management and long-term outcomes in primary vesico-ureteric reflux. 61
22085118 2011
38
Vesico-ureteric reflux: using mouse models to understand a common congenital urinary tract defect. 61
21424527 2011
39
Prevalence of sleep apnoea in diabetic patients. 61
21679352 2011
40
Human leukocyte antigens as a risk factor for the primary diseases leading to end stage renal disease in Egyptian patients. 61
23082466 2011
41
Impact of the clinical conditions at dialysis initiation on mortality in incident haemodialysis patients: a national cohort study in Taiwan. 61
20519231 2010
42
Genetic architecture of complex traits predisposing to nephropathy: hypertension. 61
20347644 2010
43
N-terminal pro-B-type natriuretic peptide: an independent marker for coronary artery disease in asymptomatic diabetic patients. 61
19719707 2009
44
High prevalence of chronic kidney disease in population-based patients diagnosed with type 2 diabetes in downtown Shanghai. 61
18280439 2008
45
Gamma heavy chain disease in a patient with diabetes and chronic renal insufficiency: diagnostic assessment of the heavy chain fragment. 61
18348312 2008
46
Operative management of ankle fractures in patients with diabetes mellitus. 61
17257535 2007
47
Psychosocial and socioeconomic risk factors for premature death in young people with type 1 diabetes. 61
15983310 2005
48
American Society of Nephrology Renal Research Report. 61
15888557 2005
49
Renoprotective effects of azelnidipine, a dihydropyridine-based calcium antagonist in advanced glycation end product (AGE)-injected rats. 61
16372480 2005
50
Diabetes, hypertension, and cardiovascular derangements: pathophysiology and management. 61
15128475 2004

Variations for Renal Failure, Progressive, with Hypertension

Expression for Renal Failure, Progressive, with Hypertension

Search GEO for disease gene expression data for Renal Failure, Progressive, with Hypertension.

Pathways for Renal Failure, Progressive, with Hypertension

GO Terms for Renal Failure, Progressive, with Hypertension

Sources for Renal Failure, Progressive, with Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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