MCID: RNL113
MIFTS: 30

Renal Failure, Progressive, with Hypertension

Categories: Cardiovascular diseases, Nephrological diseases, Rare diseases, Ear diseases, Genetic diseases

Aliases & Classifications for Renal Failure, Progressive, with Hypertension

MalaCards integrated aliases for Renal Failure, Progressive, with Hypertension:

Name: Renal Failure, Progressive, with Hypertension 57 13 73
Autosomal Dominant Progressive Nephropathy with Hypertension 59
Nephritis, Familial, Without Deafness or Ocular Defect 57
Renal Failure, Adult-Onset; Aorf 57
Renal Failure, Adult-Onset 57
Hypertensive Nephropathy 73
Nephropathy-Hypertension 57
Nephropathy, Familial 57
Rfh1 57
Aorf 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
progressive disorder
onset in young adulthood or adulthood
hypertension is presenting sign
one family has been reported (last curated december 2012)


HPO:

32
renal failure, progressive, with hypertension:
Onset and clinical course adult onset progressive
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Renal Failure, Progressive, with Hypertension

MalaCards based summary : Renal Failure, Progressive, with Hypertension, also known as autosomal dominant progressive nephropathy with hypertension, is related to hyperuricemic nephropathy, familial juvenile, 1 and hyperuricemic nephropathy, familial juvenile, 2. An important gene associated with Renal Failure, Progressive, with Hypertension is RFH1 (Renal Failure, Progressive, With Hypertension). Affiliated tissues include kidney, liver and heart, and related phenotypes are hypertension and renal insufficiency

Description from OMIM: 161900

Related Diseases for Renal Failure, Progressive, with Hypertension

Graphical network of the top 20 diseases related to Renal Failure, Progressive, with Hypertension:



Diseases related to Renal Failure, Progressive, with Hypertension

Symptoms & Phenotypes for Renal Failure, Progressive, with Hypertension

Symptoms via clinical synopsis from OMIM:

57
Cardiovascular Vascular:
hypertension

Genitourinary Kidneys:
renal failure, progressive
end-stage renal disease
renal biopsy showed interstitial fibrosis
some sclerotic glomeruli
no complement deposition

Laboratory Abnormalities:
increased serum creatinine
no proteinuria


Clinical features from OMIM:

161900

Human phenotypes related to Renal Failure, Progressive, with Hypertension:

32 (show all 7)
# Description HPO Frequency HPO Source Accession
1 hypertension 32 HP:0000822
2 renal insufficiency 32 HP:0000083
3 proteinuria 32 HP:0000093
4 elevated serum creatinine 32 HP:0003259
5 stage 5 chronic kidney disease 32 HP:0003774
6 microscopic hematuria 32 HP:0002907
7 nephritis 32 HP:0000123

Drugs & Therapeutics for Renal Failure, Progressive, with Hypertension

Search Clinical Trials , NIH Clinical Center for Renal Failure, Progressive, with Hypertension

Genetic Tests for Renal Failure, Progressive, with Hypertension

Anatomical Context for Renal Failure, Progressive, with Hypertension

MalaCards organs/tissues related to Renal Failure, Progressive, with Hypertension:

41
Kidney, Liver, Heart, Endothelial

Publications for Renal Failure, Progressive, with Hypertension

Articles related to Renal Failure, Progressive, with Hypertension:

(show all 46)
# Title Authors Year
1
Adjunctive therapy with statins reduces residual albuminuria/proteinuria and provides further renoprotection by downregulating the angiotensin II-AT1 pathway in hypertensive nephropathy. ( 28244896 )
2017
2
Deletion of Angiotensin-Converting Enzyme-2 Promotes Hypertensive Nephropathy by Targeting Smad7 for Ubiquitin Degradation. ( 28808068 )
2017
3
Hypertensive nephropathy. Moving from classic to emerging pathogenetic mechanisms. ( 27782909 )
2017
4
Identification of potential biomarkers and therapeutic targets for human IgA nephropathy and hypertensive nephropathy by bioinformatics analysis. ( 28713898 )
2017
5
Extracorporeal shock wave therapy does not improve hypertensive nephropathy. ( 27255359 )
2016
6
Sequential activation of the intrarenal renin-angiotensin system in the progression of hypertensive nephropathy in Goldblatt rats. ( 26823279 )
2016
7
OS 15-06 SEQUENTIAL ACTIVATION OF INTRARENAL ACE/ACE2 AS THE PROGRESSION OF HYPERTENSIVE NEPHROPATHY IN 2-KIDNEY 10CLIP (2K1C) GOLDBLATT RATS. ( 27754058 )
2016
8
An Analysis of Anthropometric Indicators and Modifiable Lifestyle Parameters Associated with Hypertensive Nephropathy. ( 27774313 )
2016
9
SP 01-1 ALDOSTERONE ANTAGONISTS FOR THE TREATMENT OF HYPERTENSIVE NEPHROPATHY. ( 27753857 )
2016
10
OS 15-06 SEQUENTIAL ACTIVATION OF INTRARENAL ACE/ACE2 AS THE PROGRESSION OF HYPERTENSIVE NEPHROPATHY IN 2-KIDNEY 10CLIP (2K1C) GOLDBLATT RATS. ( 27642978 )
2016
11
Identification of potential candidate genes for hypertensive nephropathy based on gene expression profile. ( 27756246 )
2016
12
SP 01-1 ALDOSTERONE ANTAGONISTS FOR THE TREATMENT OF HYPERTENSIVE NEPHROPATHY. ( 27643094 )
2016
13
Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy. ( 27558173 )
2016
14
Pharmacological inhibition of galectin-3 protects against hypertensive nephropathy. ( 25503732 )
2015
15
Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant. ( 25815268 )
2015
16
Characteristics of podocyte injury in malignant hypertensive nephropathy of rats (MSHRSP/Kpo strain). ( 26522148 )
2015
17
Avosentan is protective in hypertensive nephropathy at doses not causing fluid retention. ( 24368192 )
2014
18
Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension. ( 24511990 )
2014
19
Renoprotective activity of aliskiren, a renin inhibitor in cyclosporine A induced hypertensive nephropathy in dTG mice. ( 24905308 )
2014
20
Translational study of the Notch pathway in hypertensive nephropathy. ( 24798563 )
2014
21
Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats. ( 25352064 )
2014
22
Clinical and pathological analysis of the kidney in patients with hypertensive nephropathy. ( 24223652 )
2013
23
Altered iron homeostasis in an animal model of hypertensive nephropathy: stroke-prone rats. ( 24029866 )
2013
24
Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: role of GLP-1 and GLP-1 receptor. ( 24238127 )
2013
25
Is it variants in the apolipoprotein l1 gene, or blood pressure control, that predicts progression of nondiabetic hypertensive nephropathy in African Americans? ( 23815529 )
2013
26
Increased renal iron accumulation in hypertensive nephropathy of salt-loaded hypertensive rats. ( 24116080 )
2013
27
Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study. ( 23192770 )
2013
28
Renal-protective effect of nicousamide on hypertensive nephropathy in spontaneously hypertensive rats. ( 24648890 )
2013
29
Effects of meteorological elements on admission rates of cerebral infarction patients with hypertensive nephropathy from nine hospitals in Changchun city, Jilin Province. ( 23673113 )
2013
30
Dietary acid reduction with fruits and vegetables or bicarbonate attenuates kidney injury in patients with a moderately reduced glomerular filtration rate due to hypertensive nephropathy. ( 21881553 )
2012
31
Hypertensive nephropathy in children - do we diagnose early enough? ( 22424480 )
2012
32
Identification of periostin as a critical marker of progression/reversal of hypertensive nephropathy. ( 22403621 )
2012
33
Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats. ( 23102665 )
2012
34
Increased risk of cardiovascular events and mortality among non-diabetic chronic kidney disease patients with hypertensive nephropathy: the Gonryo study. ( 21796127 )
2011
35
Gene polymorphism of vascular endothelial growth factor -1154 G>A is associated with hypertensive nephropathy in a Hispanic population. ( 21080079 )
2011
36
Hypertensive nephropathy treatment by heart-protecting musk pill: a study of anti-inflammatory therapy for target organ damage of hypertension. ( 21475627 )
2011
37
Diabetic and hypertensive nephropathy in India. ( 21751620 )
2011
38
Increased mast cell number in human hypertensive nephropathy. ( 18684889 )
2008
39
Regression of hypertensive nephropathy during three years of optimal blood pressure control. ( 12918187 )
2003
40
African American hypertensive nephropathy maps to a new locus on chromosome 9q31-q32. ( 12840782 )
2003
41
[Hypertensive nephropathy: a growing cause of renal insufficiency]. ( 11244820 )
2001
42
Role of plasma and urinary endothelin-1 in early diabetic and hypertensive nephropathy. ( 9715792 )
1998
43
The effects of isradipine and spirapril as monotherapy and combined therapy on blood pressure, renal hemodynamics, natriuresis, and urinary kallikrein in hypertensive nephropathy. ( 9160765 )
1997
44
Hypertensive nephropathy and the gene for angiotensin-converting enzyme. ( 9081678 )
1997
45
Predictors for hypertensive nephropathy: results of a 6-year follow-up study in essential hypertension. ( 7622857 )
1995
46
Impact of antihypertensive therapy with isradipine and metoprolol on early markers of hypertensive nephropathy. ( 1533771 )
1992

Variations for Renal Failure, Progressive, with Hypertension

Expression for Renal Failure, Progressive, with Hypertension

Search GEO for disease gene expression data for Renal Failure, Progressive, with Hypertension.

Pathways for Renal Failure, Progressive, with Hypertension

GO Terms for Renal Failure, Progressive, with Hypertension

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