MCID: RNL077
MIFTS: 48

Renal Fibrosis

Categories: Nephrological diseases

Aliases & Classifications for Renal Fibrosis

MalaCards integrated aliases for Renal Fibrosis:

Name: Renal Fibrosis 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050855
UMLS 73 C0151650

Summaries for Renal Fibrosis

MalaCards based summary : Renal Fibrosis is related to ureteral obstruction and microvascular complications of diabetes 3. An important gene associated with Renal Fibrosis is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Mycophenolate mofetil and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, colon and endothelial, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Related Diseases for Renal Fibrosis

Diseases related to Renal Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 ureteral obstruction 31.0 AGTR1 BMP6 BMP7 TGFB1
2 microvascular complications of diabetes 3 29.9 AGTR1 BMP6 CTGF REN TGFB1
3 kidney disease 29.5 AGTR1 CCL2 NR3C2 REN TGFB1
4 vascular disease 28.9 BMP6 CCL2 REN SERPINE1
5 nephronophthisis 20 10.8
6 cholecystolithiasis 10.7 BMP6 CTGF TGFB1
7 localized scleroderma 10.6 CTGF SMAD3 TGFB1
8 malignant renovascular hypertension 10.6 REN SERPINE1
9 ocular cicatricial pemphigoid 10.4 CD36 CTGF TGFB1
10 pauci-immune glomerulonephritis 10.4 BMP7 CTGF SMAD2
11 scleroderma, familial progressive 10.4 BMP6 CD36 CTGF
12 gingival overgrowth 10.4 CD36 CTGF TGFB1
13 penile disease 10.4 SMAD2 SMAD3 TGFB1
14 fibromuscular dysplasia 10.4 AGTR1 REN TGFB1
15 arthrogryposis, distal, type 3 10.3 NR3C2 REN
16 malignant secondary hypertension 10.3 REN SERPINE1
17 spastic paraplegia 3, autosomal dominant 10.3 CDH1 SMAD2 TGFB1
18 idiopathic interstitial pneumonia 10.3 CCL2 CTGF SERPINE1 TGFB1
19 gingival fibromatosis 10.3 CD36 CTGF TGFB1
20 central serous chorioretinopathy 10.3 NR3C2 SERPINE1
21 anuria 10.2 AGTR1 NR3C2 REN
22 urinary system disease 10.2 CCL2 CTGF REN TGFB1
23 acquired metabolic disease 10.1 CCL2 REN SERPINE1
24 otosclerosis 10.1 AGTR1 CD36 TGFB1
25 chagas disease 10.1 CCL2 SMAD2 TGFB1
26 biliary atresia 10.1 CTGF HGF TGFB1
27 hypertensive heart disease 10.1 AGTR1 CD36 NR3C2
28 iga glomerulonephritis 10.1 AGTR1 CCL2 REN TGFB1
29 microvascular complications of diabetes 4 10.0
30 microvascular complications of diabetes 6 10.0
31 microvascular complications of diabetes 7 10.0
32 peyronie's disease 10.0 CCL2 SMAD3 SMAD7 TGFB1
33 microvascular complications of diabetes 1 10.0 CCL2 CTGF HGF
34 ischemia 10.0
35 arteries, anomalies of 10.0 AGTR1 CCL2 REN SERPINE1
36 chronic kidney failure 10.0
37 hypochondrogenesis 10.0 SMAD2 SMAD3 SMAD7
38 stroke, ischemic 9.9 AGTR1 BMP7 REN SERPINE1
39 vitreoretinopathy, neovascular inflammatory 9.9 CCL2 CTGF HGF TGFB1
40 nephrosclerosis 9.9 AGTR1 CCL2 CTGF NR3C2 TGFB1
41 hypoxia 9.8
42 glomerulonephritis 9.8
43 endotheliitis 9.8
44 pulmonary fibrosis 9.8 CCL2 CTGF SMAD3 SMAD7 TGFB1
45 hypertension, essential 9.7 AGTR1 NR3C2 REN SERPINE1
46 hypertrophic scars 9.7 BMP6 CD36 SMAD2 SMAD3 TGFB1
47 alport syndrome, x-linked 9.6
48 aging 9.6
49 acatalasemia 9.6
50 pyelonephritis 9.6

Graphical network of the top 20 diseases related to Renal Fibrosis:



Diseases related to Renal Fibrosis

Symptoms & Phenotypes for Renal Fibrosis

GenomeRNAi Phenotypes related to Renal Fibrosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 AGTR1 CCL2 CDH1 MAPK8 NR3C2 RGCC

MGI Mouse Phenotypes related to Renal Fibrosis:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.5 MAPK8 REN RGCC NPHP4 HGF NR3C2
2 growth/size/body region MP:0005378 10.4 NR3C2 MAPK8 REN RGCC HGF SMAD2
3 cellular MP:0005384 10.34 HGF NR3C2 MAPK8 NPHP4 SMAD2 SMAD7
4 hematopoietic system MP:0005397 10.29 HGF NR3C2 MAPK8 REN SMAD2 SMAD7
5 homeostasis/metabolism MP:0005376 10.27 NR3C2 REN MAPK8 CTGF SMAD3 SMAD2
6 embryo MP:0005380 10.26 HGF MAPK8 RGCC SMAD2 SMAD7 SMAD3
7 immune system MP:0005387 10.25 MAPK8 REN SMAD2 SMAD7 SMAD3 SERPINE1
8 mortality/aging MP:0010768 10.22 NR3C2 MAPK8 REN RGCC HGF SMAD2
9 endocrine/exocrine gland MP:0005379 10.21 MAPK8 SMAD2 SMAD7 SMAD3 TGFB1 SPHK1
10 digestive/alimentary MP:0005381 10.19 MAPK8 SMAD2 SMAD7 SMAD3 TGFB1 CDH1
11 craniofacial MP:0005382 10.09 MAPK8 CTGF SMAD3 SMAD2 SMAD7 TGFB1
12 integument MP:0010771 10.06 MAPK8 CTGF SMAD3 SMAD2 SMAD7 SERPINE1
13 nervous system MP:0003631 10 NR3C2 REN MAPK8 NPHP4 SMAD3 SMAD2
14 liver/biliary system MP:0005370 9.97 HGF MAPK8 CTGF SMAD2 SERPINE1 SMAD3
15 renal/urinary system MP:0005367 9.85 NR3C2 MAPK8 REN NPHP4 SMAD3 SERPINE1
16 reproductive system MP:0005389 9.65 MAPK8 REN NPHP4 SMAD2 SMAD7 SMAD3
17 vision/eye MP:0005391 9.23 MAPK8 CTGF NPHP4 SMAD3 SMAD2 TGFB1

Drugs & Therapeutics for Renal Fibrosis

Drugs for Renal Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3 128794-94-5 5281078
2
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
3
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
4
Angiotensin II Approved, Investigational Phase 4,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
5
rituximab Approved Phase 4 174722-31-7 10201696
6
Basiliximab Approved, Investigational Phase 4,Phase 3 152923-56-3, 179045-86-4
7 Anti-Bacterial Agents Phase 4,Phase 3
8 Antibiotics, Antitubercular Phase 4,Phase 3
9 Anti-Infective Agents Phase 4,Phase 3
10 Antitubercular Agents Phase 4,Phase 3
11 Calcineurin Inhibitors Phase 4,Phase 3
12 Immunosuppressive Agents Phase 4,Phase 3
13 Angiotensinogen Phase 4,Not Applicable
14 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 3
15 Antibodies Phase 4
16 Antirheumatic Agents Phase 4,Phase 3,Phase 2
17 Immunoglobulin A Phase 4
18 Immunoglobulins Phase 4
19 Vasoconstrictor Agents Phase 4
20 Antibodies, Monoclonal Phase 4
21 Antilymphocyte Serum Phase 4
22 Vaccines Phase 4
23 Omega 3 Fatty Acid Nutraceutical Phase 4
24
Eplerenone Approved Phase 3 107724-20-9 150310 443872
25
Spironolactone Approved Phase 3 1952-01-7, 52-01-7 5833
26
Everolimus Approved Phase 3 159351-69-6 6442177
27
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
28
Sirolimus Approved, Investigational Phase 3 53123-88-9 5284616 6436030 46835353
29
Ramipril Approved Phase 3 87333-19-5 5362129
30
Lactitol Investigational Phase 3 585-86-4 3871
31 Antihypertensive Agents Phase 3,Not Applicable
32 diuretics Phase 3,Phase 2
33 Diuretics, Potassium Sparing Phase 3,Phase 2
34 Hormone Antagonists Phase 3,Phase 2,Not Applicable
35 Hormones Phase 3,Phase 2,Not Applicable
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
37 Mineralocorticoid Receptor Antagonists Phase 3,Phase 2
38 Mineralocorticoids Phase 3,Phase 2
39 Natriuretic Agents Phase 3,Phase 2
40 Antifungal Agents Phase 3
41 Cyclosporins Phase 3
42 Dermatologic Agents Phase 3
43 HIV Protease Inhibitors Phase 3,Phase 2
44
protease inhibitors Phase 3,Phase 2
45
Pirfenidone Approved, Investigational Phase 2 53179-13-8 40632
46
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
47
Epinephrine Approved, Vet_approved Phase 2 51-43-4 5816
48
Racepinephrine Approved Phase 2 329-65-7 838
49 Analgesics Phase 2
50 Analgesics, Non-Narcotic Phase 2

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Effect of 3g Versus 2 g MMF in Combination With Tacrolimus on Progression of Renal Allograft Interstitial Fibrosis Unknown status NCT01860183 Phase 4 Mycophenolate mofetil
2 Rituximab in Progressive Immunoglobulin A (IgA) Nephropathy Completed NCT00498368 Phase 4 Intravenous Rituximab;ACE/ARB
3 ATG Versus Basiliximab in Kidney Transplant Displaying Low Immunological Risk But High Susceptibility to DGF Terminated NCT02056938 Phase 4 Anti-Thymocyte Globulins treatment;Basiliximab treatment
4 Effect of Eplerenone on Endothelial Function in Metabolic Syndrome Completed NCT01319344 Phase 3 Eplerenone
5 Progression of Renal Interstitial Fibrosis / Tubular Atrophy (IF/TA) According to Epithelial-mesenchymal Transition (EMT) and Immunosuppressive Regimen (Everolimus Based Versus CNI Based) in de Novo Renal Transplant Recipients Completed NCT01079143 Phase 3 Certican®;Neoral;Myfortic;Simulect®;Corticosteroids
6 Efficacy and Safety Study to Delay Renal Failure in Children With Alport Syndrome Active, not recruiting NCT01485978 Phase 3 Ramipril;placebo to ramipril;Ramipril
7 Pirfenidone to Treat Kidney Disease (Focal Segmental Glomerulosclerosis) Completed NCT00001959 Phase 2 Pirfenidone
8 Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis Completed NCT00004990 Phase 2 Dexamethasone
9 Bioprofiling Response to Mineralocorticoid Receptor Antagonists for the Prevention of Heart Failure Recruiting NCT02556450 Phase 2 Spironolacton
10 Traditional Chinese Medicine (TCM) Colon Dialysis Treats Non-dialysis End-Stage Kidney Disease Recruiting NCT03142529 Phase 1, Phase 2 colon lotion
11 Safety and Efficacy Study of Mesenchymal Stem Cell in Treating Kidney Fibrosis Not yet recruiting NCT03460223 Phase 1, Phase 2
12 Interest Of Renal Elastography In Children As A Diagnostic Tool Of Renal Fibrosis: Confrontation To Histological Features Of Renal Biopsies Unknown status NCT01613625 Not Applicable
13 Telmisartan Promotes the Differentiation of Monocytes Into Macrophages M2 in Diabetic Nephropathy? Unknown status NCT02768948 Not Applicable telmisartan during 6 months;Losartan during 6 months
14 Study of Urinary Angiotensinogen as a Marker to Warn the Deterioration of Renal Function in CKD Patients Early. Unknown status NCT01118494
15 Evaluation Of The Efficacy of a Strain-Specific Probiotic Formulation in Hemodialysis Patients Completed NCT03066921 Not Applicable
16 Multi-center Controlled Clinical Trials in Alport Syndrome-A Feasibility Study Completed NCT01696253
17 Effects of High Dietary Fiber Supplementation in Diabetic Chronic Kidney Disease Completed NCT01838330 Not Applicable
18 Role of Nox2 in CNI-induced Renal Fibrosis Recruiting NCT01674465
19 Investigations of the Optimum Serum Bicarbonate Level in Renal Disease. Active, not recruiting NCT01574157 Not Applicable Sodium bicarbonate;Placebo
20 Predictive Value of PIIINP Urinary for the Development of Chronic Renal Failure in Patients With Cystic Fibrosis After Lung Transplantation (MUCO-IRC) Terminated NCT01572194 Not Applicable
21 ACTH Treatment of APOL1- Associated Nephropathy Withdrawn NCT02006849 Not Applicable Acthar

Search NIH Clinical Center for Renal Fibrosis

Genetic Tests for Renal Fibrosis

Anatomical Context for Renal Fibrosis

MalaCards organs/tissues related to Renal Fibrosis:

41
Kidney, Colon, Endothelial, Bone, Monocytes, Heart, Lung

Publications for Renal Fibrosis

Articles related to Renal Fibrosis:

(show top 50) (show all 356)
# Title Authors Year
1
Ablation of C/EBP homologous protein attenuates renal fibrosis after ureteral obstruction by reducing autophagy and microtubule disruption. ( 29425932 )
2018
2
Resistance training attenuates inflammation and the progression of renal fibrosis in chronic renal disease. ( 29787737 )
2018
3
Human umbilical cord mesenchymal stem cell conditioned medium attenuates renal fibrosis by reducing inflammation and epithelial-to-mesenchymal transition via the TLR4/NF-I_B signaling pathway in vivo and in vitro. ( 29329595 )
2018
4
Targeting histone methyltransferase enhancer of zeste homolog-2 inhibits renal epithelial-mesenchymal transition and attenuates renal fibrosis. ( 29775417 )
2018
5
Role of hypoxia-inducible factor-1 in the development of renal fibrosis in mouse obstructed kidney: Special references to HIF-1 dependent gene expression of profibrogenic molecules. ( 29352658 )
2018
6
The effect of darbepoetin alfa on renal fibrosis in rats with acute unilateral ureteral obstruction. ( 29521269 )
2018
7
A PEG-based method for the isolation of urinary exosomes and its application in renal fibrosis diagnostics using cargo miR-29c and miR-21 analysis. ( 29330775 )
2018
8
Sphingolipid signaling in renal fibrosis. ( 29343457 )
2018
9
Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1. ( 29867511 )
2018
10
Transforming growth factor-I^ signalling in renal fibrosis: from Smads to non-coding RNAs. ( 29781524 )
2018
11
FGF23<sup>C-tail</sup> improves diabetic nephropathy by attenuating renal fibrosis and inflammation. ( 29843712 )
2018
12
Vimentin expression is required for the development of EMT-related renal fibrosis following Unilateral Ureteral Obstruction in mice. ( 29631355 )
2018
13
Effector I^I' T cells in human renal fibrosis and chronic kidney disease. ( 29897565 )
2018
14
Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI. ( 29845659 )
2018
15
Metformin attenuates folic-acid induced renal fibrosis in mice. ( 29380373 )
2018
16
MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy. ( 29932921 )
2018
17
Unraveling New Mechanisms of Renal Fibrosis With Potential Therapeutic Implications. ( 29915017 )
2018
18
The preventive and therapeutic implication for renal fibrosis by targetting TGF-I^/Smad3 signaling. ( 29875262 )
2018
19
Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury. ( 29925521 )
2018
20
Hypoxia-induced activation of Twist/miR-214/E-cadherin axis promotes renal tubular epithelial cell mesenchymal transition and renal fibrosis. ( 29277613 )
2018
21
Membrane rafts-redox signaling pathway contributes to renal fibrosis via modulation of renal tubular epithelial-mesenchymal transition. ( 29863758 )
2018
22
Adenovirus-mediated P311 ameliorates renal fibrosis through inhibition of epithelial-mesenchymal transition via TGF-I^1-Smad-ILK pathway in unilateral ureteral obstruction rats. ( 29436600 )
2018
23
Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice. ( 29277328 )
2018
24
Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells. ( 29440280 )
2018
25
Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin. ( 29976587 )
2018
26
Celastrol alleviates renal fibrosis by upregulating cannabinoid receptor 2 expression. ( 29789558 )
2018
27
Targeting ARNT to attenuate renal fibrosis. ( 29955104 )
2018
28
Impairment of PPAR<i>I+</i>and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging. ( 29440279 )
2018
29
Renal fibrosis: Primacy of the proximal tubule. ( 29425694 )
2018
30
Novel RAS Inhibitors Poricoic Acid ZG and Poricoic Acid ZH Attenuate Renal Fibrosis via a Wnt/I^-Catenin Pathway and Targeted Phosphorylation of smad3 Signaling. ( 29383936 )
2018
31
Silencing of LncRNA TCONS_00088786 reduces renal fibrosis through miR-132. ( 29364484 )
2018
32
Cryptotanshinone hinders renal fibrosis and epithelial transdifferentiation in obstructive nephropathy by inhibiting TGF-I^1/Smad3/integrin I^1 signal. ( 29928474 )
2018
33
Identification of candidate microRNA biomarkers in renal fibrosis: a meta-analysis of profiling studies. ( 29909697 )
2018
34
Correction: Secretion of ERP57 is important for extracellular matrix accumulation and progression of renal fibrosis, and is an early sign of disease onset (doi:10.1242/jcs.125088). ( 29973398 )
2018
35
Effects of cholecalciferol cholesterol emulsion on renal fibrosis and aquaporin 2 and 4 in mice with unilateral ureteral obstruction. ( 29602131 )
2018
36
Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-I_B signaling pathways in diabetic nephropathy. ( 29795979 )
2018
37
Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice. ( 29973247 )
2018
38
Pioglitazone Improves Mitochondrial Function in the Remnant Kidney and Protects against Renal Fibrosis in 5/6 Nephrectomized Rats. ( 28860994 )
2017
39
Selective tubular activation of hypoxia-inducible factor-2I+ has dual effects on renal fibrosis. ( 28900259 )
2017
40
Feature selection and classification of urinary mRNA microarray data by iterative random forest to diagnose renal fibrosis: a two-stage study. ( 28045061 )
2017
41
The Differential Effect of Apyrase Treatment and hCD39 Overexpression on Chronic Renal Fibrosis After Ischemia-Reperfusion Injury. ( 28198766 )
2017
42
Corrigendum to &amp;quot;Dual Inhibiting Senescence and Epithelial-to-Mesenchymal Transition by Erythropoietin Preserve Tubular Epithelial Cell Regeneration and Ameliorate Renal Fibrosis in Unilateral Ureteral Obstruction&amp;quot;. ( 28567417 )
2017
43
PHF14: an innate inhibitor against the progression of renal fibrosis following folic acid-induced kidney injury. ( 28045076 )
2017
44
H2S improves renal fibrosis in STZ-induced diabetic rats by ameliorating TGF-I^1 expression. ( 27882817 )
2017
45
Deficiency of mPGES-1 exacerbates renal fibrosis and inflammation in mice with unilateral ureteral obstruction. ( 27784694 )
2017
46
Intermedin attenuates renal fibrosis by induction of heme oxygenase-1 in rats with unilateral ureteral obstruction. ( 28697727 )
2017
47
Psoralea corylifolia L. Seed Extract Attenuates Diabetic Nephropathy by Inhibiting Renal Fibrosis and Apoptosis in Streptozotocin-Induced Diabetic Mice. ( 28767064 )
2017
48
Role of Stat3 Signaling in Control of EMT of Tubular Epithelial Cells During Renal Fibrosis. ( 28848189 )
2017
49
Potential association between elevated serum human epididymis protein 4 and renal fibrosis: A systemic review and meta-analysis. ( 28885334 )
2017
50
Murine Precision-Cut Kidney Slices as an<i>ex vivo</i>Model to Evaluate the Role of Transforming Growth Factor-I^1 Signaling in the Onset of Renal Fibrosis. ( 29311960 )
2017

Variations for Renal Fibrosis

Expression for Renal Fibrosis

Search GEO for disease gene expression data for Renal Fibrosis.

Pathways for Renal Fibrosis

Pathways related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 BMP6 BMP7 CCL2 CDH1 CTGF HGF
2
Show member pathways
13.51 AGTR1 BMP6 BMP7 CCL2 CTGF HGF
3
Show member pathways
13.4 BMP6 BMP7 CCL2 CTGF HGF MAPK8
4
Show member pathways
13.32 BMP6 BMP7 CCL2 CDH1 CTGF HGF
5
Show member pathways
13.27 BMP6 BMP7 CDH1 CTGF HGF MAPK8
6
Show member pathways
13.04 AGTR1 BMP6 BMP7 CCL2 CTGF HGF
7
Show member pathways
13 CCL2 MAPK8 SERPINE1 SMAD2 SMAD3 TGFB1
8 12.87 AGTR1 CDH1 HGF MAPK8 SMAD2 SMAD3
9
Show member pathways
12.85 CDH1 MAPK8 SMAD2 SMAD3 TGFB1
10
Show member pathways
12.76 CDH1 HGF SMAD2 SMAD3 TGFB1
11
Show member pathways
12.69 BMP6 BMP7 CTGF HGF TGFB1
12
Show member pathways
12.54 CDH1 MAPK8 SMAD2 SMAD3 TGFB1
13
Show member pathways
12.49 BMP7 SMAD2 SMAD3 SPHK1 TGFB1
14
Show member pathways
12.43 MAPK8 SMAD2 SMAD3 TGFB1
15 12.41 MAPK8 SMAD2 SMAD3 TGFB1
16 12.36 CDH1 SMAD2 SMAD3 TGFB1
17
Show member pathways
12.33 SERPINE1 SMAD2 SMAD3 SMAD7 TGFB1
18 12.24 BMP6 BMP7 CTGF SERPINE1 SMAD2 SMAD3
19
Show member pathways
12.22 MAPK8 SMAD2 SMAD3 TGFB1
20 12.18 CDH1 SMAD2 SMAD3 TGFB1
21 12.16 SERPINE1 SMAD2 SMAD3 TGFB1
22 12.11 MAPK8 SMAD2 SMAD3 SMAD7 TGFB1
23 12.1 BMP6 BMP7 MAPK8 SMAD2 SMAD3 TGFB1
24
Show member pathways
12.09 MAPK8 SMAD2 SMAD3 TGFB1
25 12.05 AGTR1 CDH1 CTGF SERPINE1 SMAD2 SMAD3
26 12 CCL2 CD36 HGF TGFB1
27 11.95 MAPK8 SMAD2 SMAD3 SMAD7 TGFB1
28 11.89 CCL2 HGF REN TGFB1
29
Show member pathways
11.85 SMAD2 SMAD3 TGFB1
30
Show member pathways
11.84 AGTR1 NR3C2 REN TGFB1
31
Show member pathways
11.81 MAPK8 SMAD2 SMAD3 TGFB1
32 11.81 BMP6 BMP7 SMAD2 SMAD3 SMAD7 TGFB1
33 11.8 SERPINE1 SMAD2 SMAD3 SMAD7
34 11.8 AGTR1 CCL2 MAPK8 SERPINE1 SMAD2 SMAD3
35 11.8 BMP6 BMP7 CDH1 CTGF SERPINE1 SMAD2
36 11.78 SERPINE1 SMAD2 SMAD3 SMAD7 TGFB1
37
Show member pathways
11.76 SMAD2 SMAD3 SMAD7 TGFB1
38 11.73 CDH1 SMAD2 SMAD3
39
Show member pathways
11.72 BMP6 BMP7 SMAD7
40 11.68 MAPK8 SMAD2 SMAD3
41 11.67 BMP6 BMP7 TGFB1
42 11.64 SERPINE1 SMAD2 SMAD3 SMAD7 TGFB1
43 11.6 BMP7 CCL2 CTGF HGF SMAD7 TGFB1
44 11.58 CCL2 CD36 HGF TGFB1
45 11.56 CTGF SMAD2 SMAD3 SMAD7 TGFB1
46 11.55 MAPK8 SMAD3 TGFB1
47
Show member pathways
11.54 MAPK8 SMAD2 SMAD3 TGFB1
48
Show member pathways
11.38 BMP6 BMP7 CCL2 CDH1 CTGF HGF
49 11.34 HGF SMAD2 SMAD3 TGFB1
50 11.05 CDH1 SMAD2 SMAD3 TGFB1

GO Terms for Renal Fibrosis

Cellular components related to Renal Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.76 AGTR1 CCL2 CD36 MAPK8 REN SMAD2
2 extracellular space GO:0005615 9.61 BMP6 BMP7 CCL2 CD36 CTGF HGF
3 platelet alpha granule lumen GO:0031093 9.43 HGF SERPINE1 TGFB1
4 SMAD protein complex GO:0071141 9.32 SMAD2 SMAD3
5 heteromeric SMAD protein complex GO:0071144 8.62 SMAD2 SMAD3
6 extracellular region GO:0005576 10.02 BMP6 BMP7 CCL2 CDH1 CTGF HGF

Biological processes related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.99 CD36 CTGF SMAD2 TGFB1
2 positive regulation of cell migration GO:0030335 9.98 HGF SMAD3 SPHK1 TGFB1
3 cellular response to lipopolysaccharide GO:0071222 9.93 CCL2 CD36 MAPK8 SERPINE1
4 platelet degranulation GO:0002576 9.92 CD36 HGF SERPINE1 TGFB1
5 response to estradiol GO:0032355 9.91 BMP7 CTGF TGFB1
6 response to organic substance GO:0010033 9.91 CDH1 REN TGFB1
7 wound healing GO:0042060 9.91 SMAD2 SMAD3 TGFB1
8 ossification GO:0001503 9.9 BMP6 BMP7 CTGF
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.89 CD36 HGF TGFB1
10 cellular response to mechanical stimulus GO:0071260 9.89 BMP6 MAPK8 TGFB1
11 kidney development GO:0001822 9.89 AGTR1 BMP6 BMP7 REN
12 response to glucose GO:0009749 9.88 CTGF SMAD2 TGFB1
13 cell chemotaxis GO:0060326 9.88 AGTR1 CCL2 HGF
14 cell development GO:0048468 9.85 BMP6 BMP7 TGFB1
15 transforming growth factor beta receptor signaling pathway GO:0007179 9.85 SMAD2 SMAD3 SMAD7 TGFB1
16 cellular response to transforming growth factor beta stimulus GO:0071560 9.84 SMAD3 SMAD7 TGFB1
17 positive regulation of osteoblast differentiation GO:0045669 9.84 BMP6 BMP7 HGF
18 BMP signaling pathway GO:0030509 9.84 BMP6 BMP7 SMAD7 TGFB1
19 positive regulation of cell death GO:0010942 9.83 BMP7 CD36 CTGF
20 positive regulation of stress fiber assembly GO:0051496 9.83 CTGF RGCC SMAD3
21 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.83 SMAD2 SMAD3 SMAD7 TGFB1
22 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.82 BMP6 BMP7 TGFB1
23 regulation of MAPK cascade GO:0043408 9.81 BMP6 BMP7 REN TGFB1
24 epithelial to mesenchymal transition GO:0001837 9.8 BMP7 HGF TGFB1
25 mesoderm formation GO:0001707 9.8 BMP7 SMAD2 SMAD3
26 endoderm development GO:0007492 9.79 SMAD2 SMAD3 TGFB1
27 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.78 BMP7 SPHK1 TGFB1
28 positive regulation of protein import into nucleus GO:0042307 9.77 CDH1 SMAD3 TGFB1
29 embryonic pattern specification GO:0009880 9.76 BMP7 SMAD2 SMAD3
30 positive regulation of gene expression GO:0010628 9.76 BMP7 CD36 CTGF MAPK8 RGCC SMAD2
31 negative regulation of cell-cell adhesion GO:0022408 9.73 CDH1 TGFB1
32 positive regulation of blood coagulation GO:0030194 9.73 CD36 SERPINE1
33 negative regulation of wound healing GO:0061045 9.73 SERPINE1 SMAD3
34 positive regulation of collagen biosynthetic process GO:0032967 9.73 CTGF RGCC TGFB1
35 positive regulation of bone mineralization GO:0030501 9.73 BMP6 BMP7 SMAD3 TGFB1
36 mesonephros development GO:0001823 9.72 BMP7 REN
37 positive regulation of DNA biosynthetic process GO:2000573 9.72 HGF RGCC
38 pathway-restricted SMAD protein phosphorylation GO:0060389 9.72 SMAD7 TGFB1
39 lens fiber cell differentiation GO:0070306 9.72 SMAD3 TGFB1
40 positive regulation of SMAD protein signal transduction GO:0060391 9.71 BMP6 TGFB1
41 response to cholesterol GO:0070723 9.7 SMAD2 TGFB1
42 nodal signaling pathway GO:0038092 9.7 SMAD2 SMAD3
43 salivary gland morphogenesis GO:0007435 9.7 BMP7 TGFB1
44 primary miRNA processing GO:0031053 9.7 SMAD2 SMAD3
45 pericardium development GO:0060039 9.69 SMAD2 SMAD3
46 embryonic foregut morphogenesis GO:0048617 9.69 SMAD2 SMAD3
47 response to laminar fluid shear stress GO:0034616 9.68 SMAD7 TGFB1
48 regulation of removal of superoxide radicals GO:2000121 9.67 BMP7 CD36
49 common-partner SMAD protein phosphorylation GO:0007182 9.66 SMAD2 TGFB1
50 SMAD protein signal transduction GO:0060395 9.65 BMP6 BMP7 SMAD2 SMAD3 TGFB1

Molecular functions related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.88 AGTR1 BMP6 HGF SMAD2 SMAD3 TGFB1
2 cytokine activity GO:0005125 9.78 BMP6 BMP7 CCL2 TGFB1
3 beta-catenin binding GO:0008013 9.69 CDH1 SMAD3 SMAD7
4 growth factor activity GO:0008083 9.65 BMP6 BMP7 CTGF HGF TGFB1
5 R-SMAD binding GO:0070412 9.54 RGCC SMAD2 SMAD3
6 co-SMAD binding GO:0070410 9.52 SMAD2 SMAD3
7 I-SMAD binding GO:0070411 9.49 SMAD2 SMAD7
8 primary miRNA binding GO:0070878 9.46 SMAD2 SMAD3
9 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.43 SMAD2 SMAD3
10 BMP receptor binding GO:0070700 9.33 BMP6 BMP7 TGFB1
11 type I transforming growth factor beta receptor binding GO:0034713 9.13 SMAD2 SMAD7 TGFB1
12 transforming growth factor beta receptor binding GO:0005160 9.02 BMP6 BMP7 SMAD2 SMAD3 TGFB1
13 protein binding GO:0005515 10.3 AGTR1 BMP7 CCL2 CD36 CDH1 CTGF

Sources for Renal Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
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54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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