MCID: RNL077
MIFTS: 50

Renal Fibrosis

Categories: Nephrological diseases

Aliases & Classifications for Renal Fibrosis

MalaCards integrated aliases for Renal Fibrosis:

Name: Renal Fibrosis 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050855
UMLS 73 C0151650

Summaries for Renal Fibrosis

MalaCards based summary : Renal Fibrosis is related to ureteral obstruction and obstructive nephropathy. An important gene associated with Renal Fibrosis is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Tacrolimus and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and endothelial, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Related Diseases for Renal Fibrosis

Diseases related to Renal Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 ureteral obstruction 31.0 AGTR1 BMP6 BMP7 TGFB1
2 obstructive nephropathy 30.1 HGF REN SMAD2 SMAD3 TGFB1
3 kidney disease 30.1 AGTR1 BMP7 CCL2 CCN2 NR3C2 REN
4 iga glomerulonephritis 29.6 AGTR1 CCL2 REN TGFB1
5 vascular disease 29.3 BMP6 CCL2 REN SERPINE1
6 urinary tract obstruction 28.6 CCL2 CCN2 CDH1 REN SMAD2 SMAD3
7 nephronophthisis 20 10.9
8 microvascular complications of diabetes 3 10.4
9 microvascular complications of diabetes 4 10.4
10 microvascular complications of diabetes 6 10.4
11 microvascular complications of diabetes 7 10.4
12 chronic kidney failure 10.3
13 ischemia 10.3
14 malignant hypertensive renal disease 10.2 REN SERPINE1
15 malignant renovascular hypertension 10.2 REN SERPINE1
16 diabetic foot ulcers 10.2 CCL2 TGFB1
17 ocular cicatricial pemphigoid 10.1 CCN2 CD36 TGFB1
18 heart valve disease 10.1 NR3C2 REN TGFB1
19 fibromuscular dysplasia 10.1 AGTR1 REN TGFB1
20 malignant secondary hypertension 10.1 REN SERPINE1
21 respiratory system disease 10.1 CCL2 CDH1 TGFB1
22 pauci-immune glomerulonephritis 10.1 BMP7 CCN2 SMAD2
23 central serous chorioretinopathy 10.1 NR3C2 SERPINE1
24 gingival overgrowth 10.1 CCN2 CD36 TGFB1
25 spondylocarpotarsal synostosis syndrome 10.1 CCN2 SMAD2 SMAD3
26 spastic paraplegia 3, autosomal dominant 10.1 CDH1 SMAD2 TGFB1
27 idiopathic interstitial pneumonia 10.1 CCL2 CCN2 SERPINE1 TGFB1
28 anuria 10.1 AGTR1 NR3C2 REN
29 familial hypertension 10.0 AGTR1 NR3C2 REN
30 acquired metabolic disease 10.0 CCL2 REN SERPINE1
31 hypoxia 10.0
32 otosclerosis 10.0 AGTR1 CD36 TGFB1
33 chagas disease 10.0 CCL2 SMAD2 TGFB1
34 nephrosclerosis 10.0 AGTR1 CCL2 NR3C2 TGFB1
35 arthrogryposis, distal, type 3 10.0 NR3C2 REN
36 hypertensive heart disease 10.0 AGTR1 CD36 NR3C2
37 peyronie's disease 10.0 CCL2 SMAD3 SMAD7 TGFB1
38 arteries, anomalies of 10.0 AGTR1 CCL2 REN SERPINE1
39 stroke, ischemic 10.0 AGTR1 BMP7 REN SERPINE1
40 renal dysplasia 10.0 AGTR1 NPHP4 REN
41 vitreoretinopathy, neovascular inflammatory 9.9 CCL2 HGF TGFB1
42 hypochondrogenesis 9.9 SMAD2 SMAD3 SMAD7
43 urinary system disease 9.9 AGTR1 CCL2 CCN2 REN TGFB1
44 renal artery disease 9.9 AGTR1 REN
45 glomerulonephritis 9.9
46 hypertension, essential 9.9 AGTR1 NR3C2 REN SERPINE1
47 pulmonary fibrosis 9.9 CCL2 CCN2 SMAD3 SMAD7 TGFB1
48 microvascular complications of diabetes 1 9.9 CCL2 CCN2 HGF
49 hypertrophic scars 9.9 BMP6 CD36 SMAD2 SMAD3 TGFB1
50 ewing sarcoma 9.8 CCN2 CDH1 MAPK8 SERPINE1 TGFB1

Graphical network of the top 20 diseases related to Renal Fibrosis:



Diseases related to Renal Fibrosis

Symptoms & Phenotypes for Renal Fibrosis

GenomeRNAi Phenotypes related to Renal Fibrosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 AGTR1 CCL2 CDH1 MAPK8 NR3C2 RGCC

MGI Mouse Phenotypes related to Renal Fibrosis:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.5 AGTR1 BMP7 CCN2 CD36 CDH1 HGF
2 growth/size/body region MP:0005378 10.4 AGTR1 BMP6 BMP7 CCN2 CD36 CDH1
3 cellular MP:0005384 10.34 CCN2 CD36 CDH1 HGF MAPK8 NPHP4
4 hematopoietic system MP:0005397 10.29 AGTR1 BMP7 CD36 HGF MAPK8 NR3C2
5 homeostasis/metabolism MP:0005376 10.27 AGTR1 CCN2 CD36 CDH1 MAPK8 NR3C2
6 embryo MP:0005380 10.26 BMP7 CCN2 CDH1 HGF MAPK8 RGCC
7 immune system MP:0005387 10.25 AGTR1 BMP7 CCL2 CD36 CDH1 MAPK8
8 mortality/aging MP:0010768 10.22 AGTR1 BMP7 CCN2 CD36 CDH1 HGF
9 endocrine/exocrine gland MP:0005379 10.21 BMP7 CCN2 CD36 CDH1 MAPK8 SMAD2
10 digestive/alimentary MP:0005381 10.19 BMP7 CCN2 CD36 CDH1 MAPK8 SMAD2
11 craniofacial MP:0005382 10.09 BMP7 CCN2 MAPK8 SMAD2 SMAD3 SMAD7
12 integument MP:0010771 10.06 BMP7 CCN2 CDH1 MAPK8 SERPINE1 SMAD2
13 nervous system MP:0003631 10 AGTR1 BMP7 CD36 MAPK8 NPHP4 NR3C2
14 liver/biliary system MP:0005370 9.97 CCN2 CD36 HGF MAPK8 SERPINE1 SMAD2
15 renal/urinary system MP:0005367 9.85 AGTR1 BMP7 CD36 MAPK8 NPHP4 NR3C2
16 reproductive system MP:0005389 9.65 BMP6 BMP7 CDH1 MAPK8 NPHP4 REN
17 vision/eye MP:0005391 9.23 BMP7 CCN2 CD36 MAPK8 NPHP4 SMAD2

Drugs & Therapeutics for Renal Fibrosis

Drugs for Renal Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
2
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
3
Angiotensin II Approved, Investigational Phase 4,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
4
rituximab Approved Phase 4 174722-31-7 10201696
5
Basiliximab Approved, Investigational Phase 4,Phase 3 152923-56-3, 179045-86-4
6 Calcineurin Inhibitors Phase 4,Phase 3
7 Anti-Bacterial Agents Phase 4,Phase 3
8 Anti-Infective Agents Phase 4,Phase 3
9 Immunosuppressive Agents Phase 4,Phase 3
10 Antibiotics, Antitubercular Phase 4,Phase 3
11 Immunologic Factors Phase 4,Phase 3
12 Antitubercular Agents Phase 4,Phase 3
13 Angiotensinogen Phase 4,Not Applicable
14 Antibodies Phase 4
15 Omega 3 Fatty Acid Phase 4
16 Immunoglobulins Phase 4
17 Immunoglobulin A Phase 4
18 Vasoconstrictor Agents Phase 4
19 Antirheumatic Agents Phase 4,Phase 3,Phase 2
20 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 3
21 Antilymphocyte Serum Phase 4
22 Antibodies, Monoclonal Phase 4
23 Thymoglobulin Phase 4
24 Vaccines Phase 4
25
Spironolactone Approved Phase 3 52-01-7, 1952-01-7 5833
26
Eplerenone Approved Phase 3 107724-20-9 443872 150310
27
Sirolimus Approved, Investigational Phase 3 53123-88-9 46835353 6436030 5284616
28
Everolimus Approved Phase 3 159351-69-6 6442177
29
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
30
Ramipril Approved Phase 3 87333-19-5 5362129
31
Lactitol Investigational Phase 3 585-86-4 3871
32 Hormones Phase 3,Phase 2,Not Applicable
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
34 diuretics Phase 3,Phase 2
35 Mineralocorticoids Phase 3,Phase 2
36 Hormone Antagonists Phase 3,Phase 2,Not Applicable
37 Diuretics, Potassium Sparing Phase 3,Phase 2
38 Natriuretic Agents Phase 3,Phase 2
39 Mineralocorticoid Receptor Antagonists Phase 3,Phase 2
40 Antifungal Agents Phase 3
41 Dermatologic Agents Phase 3
42 Cyclosporins Phase 3
43
protease inhibitors Phase 3,Phase 2
44 HIV Protease Inhibitors Phase 3,Phase 2
45 Antihypertensive Agents Phase 3,Not Applicable
46
Pirfenidone Approved, Investigational Phase 2 53179-13-8 40632
47
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
48
Racepinephrine Approved Phase 2 329-65-7 838
49
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
50
Epinephrine Approved, Vet_approved Phase 2 51-43-4 5816

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Effect of 3g Versus 2 g MMF in Combination With Tacrolimus on Progression of Renal Allograft Interstitial Fibrosis Unknown status NCT01860183 Phase 4 Mycophenolate mofetil
2 Rituximab in Progressive Immunoglobulin A (IgA) Nephropathy Completed NCT00498368 Phase 4 Intravenous Rituximab;ACE/ARB
3 ATG Versus Basiliximab in Kidney Transplant Displaying Low Immunological Risk But High Susceptibility to DGF Terminated NCT02056938 Phase 4 Anti-Thymocyte Globulins treatment;Basiliximab treatment
4 Effect of Eplerenone on Endothelial Function in Metabolic Syndrome Completed NCT01319344 Phase 3 Eplerenone
5 Progression of Renal Interstitial Fibrosis / Tubular Atrophy (IF/TA) According to Epithelial-mesenchymal Transition (EMT) and Immunosuppressive Regimen (Everolimus Based Versus CNI Based) in de Novo Renal Transplant Recipients Completed NCT01079143 Phase 3 Certican®;Neoral;Myfortic;Simulect®;Corticosteroids
6 Efficacy and Safety Study to Delay Renal Failure in Children With Alport Syndrome Active, not recruiting NCT01485978 Phase 3 Ramipril;placebo to ramipril;Ramipril
7 Pirfenidone to Treat Kidney Disease (Focal Segmental Glomerulosclerosis) Completed NCT00001959 Phase 2 Pirfenidone
8 Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis Completed NCT00004990 Phase 2 Dexamethasone
9 Traditional Chinese Medicine (TCM) Colon Dialysis Treats Non-dialysis End-Stage Kidney Disease Recruiting NCT03142529 Phase 1, Phase 2 colon lotion
10 Bioprofiling Response to Mineralocorticoid Receptor Antagonists for the Prevention of Heart Failure Active, not recruiting NCT02556450 Phase 2 Spironolacton
11 Safety and Efficacy Study of Mesenchymal Stem Cell in Treating Kidney Fibrosis Not yet recruiting NCT03460223 Phase 1, Phase 2
12 Interest Of Renal Elastography In Children As A Diagnostic Tool Of Renal Fibrosis: Confrontation To Histological Features Of Renal Biopsies Unknown status NCT01613625 Not Applicable
13 Study of Urinary Angiotensinogen as a Marker to Warn the Deterioration of Renal Function in CKD Patients Early. Unknown status NCT01118494
14 Evaluation Of The Efficacy of a Strain-Specific Probiotic Formulation in Hemodialysis Patients Completed NCT03066921 Not Applicable
15 Multi-center Controlled Clinical Trials in Alport Syndrome-A Feasibility Study Completed NCT01696253
16 Investigations of the Optimum Serum Bicarbonate Level in Renal Disease. Completed NCT01574157 Not Applicable Sodium bicarbonate;Placebo
17 Effects of High Dietary Fiber Supplementation in Diabetic Chronic Kidney Disease Completed NCT01838330 Not Applicable
18 Telmisartan Promotes the Differentiation of Monocytes Into Macrophages M2 in Diabetic Nephropathy? Recruiting NCT02768948 Not Applicable telmisartan during 6 months;Losartan during 6 months
19 MRI in Renal Transplantation Recruiting NCT03705091
20 Role of Nox2 in CNI-induced Renal Fibrosis Active, not recruiting NCT01674465
21 Predictive Value of PIIINP Urinary for the Development of Chronic Renal Failure in Patients With Cystic Fibrosis After Lung Transplantation (MUCO-IRC) Terminated NCT01572194 Not Applicable
22 ACTH Treatment of APOL1- Associated Nephropathy Withdrawn NCT02006849 Not Applicable Acthar

Search NIH Clinical Center for Renal Fibrosis

Genetic Tests for Renal Fibrosis

Anatomical Context for Renal Fibrosis

MalaCards organs/tissues related to Renal Fibrosis:

41
Kidney, Bone, Endothelial, Monocytes, T Cells, Heart, Liver

Publications for Renal Fibrosis

Articles related to Renal Fibrosis:

(show top 50) (show all 1016)
# Title Authors Year
1
Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy. ( 30551434 )
2019
2
Ablation of C/EBP homologous protein attenuates renal fibrosis after ureteral obstruction by reducing autophagy and microtubule disruption. ( 29425932 )
2018
3
Resistance training attenuates inflammation and the progression of renal fibrosis in chronic renal disease. ( 29787737 )
2018
4
Human umbilical cord mesenchymal stem cell conditioned medium attenuates renal fibrosis by reducing inflammation and epithelial-to-mesenchymal transition via the TLR4/NF-I_B signaling pathway in vivo and in vitro. ( 29329595 )
2018
5
Targeting histone methyltransferase enhancer of zeste homolog-2 inhibits renal epithelial-mesenchymal transition and attenuates renal fibrosis. ( 29775417 )
2018
6
Role of hypoxia-inducible factor-1 in the development of renal fibrosis in mouse obstructed kidney: Special references to HIF-1 dependent gene expression of profibrogenic molecules. ( 29352658 )
2018
7
The effect of darbepoetin alfa on renal fibrosis in rats with acute unilateral ureteral obstruction. ( 29521269 )
2018
8
A PEG-based method for the isolation of urinary exosomes and its application in renal fibrosis diagnostics using cargo miR-29c and miR-21 analysis. ( 29330775 )
2018
9
Sphingolipid signaling in renal fibrosis. ( 29343457 )
2018
10
Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1. ( 29867511 )
2018
11
Transforming growth factor-I^ signalling in renal fibrosis: from Smads to non-coding RNAs. ( 29781524 )
2018
12
FGF23<sup>C-tail</sup> improves diabetic nephropathy by attenuating renal fibrosis and inflammation. ( 29843712 )
2018
13
Vimentin expression is required for the development of EMT-related renal fibrosis following Unilateral Ureteral Obstruction in mice. ( 29631355 )
2018
14
Effector I^I' T cells in human renal fibrosis and chronic kidney disease. ( 29897565 )
2018
15
Assessment of renal fibrosis in murine diabetic nephropathy using quantitative magnetization transfer MRI. ( 29845659 )
2018
16
Metformin attenuates folic-acid induced renal fibrosis in mice. ( 29380373 )
2018
17
MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy. ( 29932921 )
2018
18
Unraveling New Mechanisms of Renal Fibrosis With Potential Therapeutic Implications. ( 29915017 )
2018
19
The preventive and therapeutic implication for renal fibrosis by targetting TGF-I^/Smad3 signaling. ( 29875262 )
2018
20
Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury. ( 29925521 )
2018
21
Hypoxia-induced activation of Twist/miR-214/E-cadherin axis promotes renal tubular epithelial cell mesenchymal transition and renal fibrosis. ( 29277613 )
2018
22
Membrane rafts-redox signaling pathway contributes to renal fibrosis via modulation of renal tubular epithelial-mesenchymal transition. ( 29863758 )
2018
23
Adenovirus-mediated P311 ameliorates renal fibrosis through inhibition of epithelial-mesenchymal transition via TGF-I^1-Smad-ILK pathway in unilateral ureteral obstruction rats. ( 29436600 )
2018
24
Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice. ( 29277328 )
2018
25
Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells. ( 29440280 )
2018
26
Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin. ( 29976587 )
2018
27
Celastrol alleviates renal fibrosis by upregulating cannabinoid receptor 2 expression. ( 29789558 )
2018
28
Targeting ARNT to attenuate renal fibrosis. ( 29955104 )
2018
29
Impairment of PPAR<i>I+</i>and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging. ( 29440279 )
2018
30
Renal fibrosis: Primacy of the proximal tubule. ( 29425694 )
2018
31
Novel RAS Inhibitors Poricoic Acid ZG and Poricoic Acid ZH Attenuate Renal Fibrosis via a Wnt/I^-Catenin Pathway and Targeted Phosphorylation of smad3 Signaling. ( 29383936 )
2018
32
Silencing of LncRNA TCONS_00088786 reduces renal fibrosis through miR-132. ( 29364484 )
2018
33
Cryptotanshinone hinders renal fibrosis and epithelial transdifferentiation in obstructive nephropathy by inhibiting TGF-I^1/Smad3/integrin I^1 signal. ( 29928474 )
2018
34
Identification of candidate microRNA biomarkers in renal fibrosis: a meta-analysis of profiling studies. ( 29909697 )
2018
35
Correction: Secretion of ERP57 is important for extracellular matrix accumulation and progression of renal fibrosis, and is an early sign of disease onset (doi:10.1242/jcs.125088). ( 29973398 )
2018
36
Effects of cholecalciferol cholesterol emulsion on renal fibrosis and aquaporin 2 and 4 in mice with unilateral ureteral obstruction. ( 29602131 )
2018
37
Rapeseed protein-derived antioxidant peptide RAP alleviates renal fibrosis through MAPK/NF-I_B signaling pathways in diabetic nephropathy. ( 29795979 )
2018
38
Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis. ( 30127380 )
2018
39
Losartan Alleviates Renal Fibrosis and Inhibits Endothelial-to-Mesenchymal Transition (EMT) Under High-Fat Diet-Induced Hyperglycemia. ( 30420805 )
2018
40
MicroRNA-493 targets STMN-1 and promotes hypoxia-induced epithelial cell cycle arrest in G2/M and renal fibrosis. ( 30183377 )
2018
41
p53 Upregulated by HIF-1α Promotes Hypoxia-induced G2/M Arrest and Renal Fibrosis in vitro and in vivo. ( 30032308 )
2018
42
STAT1 regulates macrophage number and phenotype and prevents renal fibrosis after ischemia/reperfusion injury. ( 30403164 )
2018
43
Pharmacological inhibition of Rac1 exerts a protective role in ischemia/reperfusion-induced renal fibrosis. ( 30208520 )
2018
44
Inhibition of IL-18 reduces renal fibrosis after ischemia-reperfusion. ( 30119258 )
2018
45
Effects of Post Ischemia-Reperfusion Treatment with Trimetazidine on Renal Injury in Rats: Insights on Delayed Renal Fibrosis Progression. ( 30057668 )
2018
46
Targeted Ablation of Distal Cerebrospinal Fluid-Contacting Nucleus Alleviates Renal Fibrosis in Chronic Kidney Disease. ( 30524304 )
2018
47
Histone deacetylase inhibitor, CG200745 attenuates renal fibrosis in obstructive kidney disease. ( 30068917 )
2018
48
Urinary metalloproteinases and tissue inhibitors of metalloproteinases as potential early biomarkers for renal fibrosis in children with nephrotic syndrome. ( 29465592 )
2018
49
Ginsenoside-Rg1 Protects against Renal Fibrosis by Regulating the Klotho/TGF-β1/Smad Signaling Pathway in Rats with Obstructive Nephropathy. ( 29607931 )
2018
50
S100A8/A9 promotes parenchymal damage and renal fibrosis in obstructive nephropathy. ( 29746703 )
2018

Variations for Renal Fibrosis

Expression for Renal Fibrosis

Search GEO for disease gene expression data for Renal Fibrosis.

Pathways for Renal Fibrosis

Pathways related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 BMP6 BMP7 CCL2 CCN2 CDH1 HGF
2
Show member pathways
13.49 AGTR1 BMP6 BMP7 CCL2 CCN2 CDH1
3
Show member pathways
13.41 BMP6 BMP7 CCL2 CCN2 HGF MAPK8
4
Show member pathways
13.33 BMP6 BMP7 CCL2 CCN2 CDH1 HGF
5
Show member pathways
13.29 BMP6 BMP7 CCN2 CDH1 HGF MAPK8
6
Show member pathways
13.06 AGTR1 BMP6 BMP7 CCL2 CCN2 HGF
7
Show member pathways
13.02 CCL2 MAPK8 SERPINE1 SMAD2 SMAD3 TGFB1
8 12.88 AGTR1 CDH1 HGF MAPK8 SMAD2 SMAD3
9
Show member pathways
12.86 CDH1 MAPK8 SMAD2 SMAD3 TGFB1
10
Show member pathways
12.77 CDH1 HGF SMAD2 SMAD3 TGFB1
11
Show member pathways
12.71 BMP6 BMP7 CCN2 HGF TGFB1
12
Show member pathways
12.56 CDH1 MAPK8 SMAD2 SMAD3 TGFB1
13
Show member pathways
12.5 BMP7 SMAD2 SMAD3 SPHK1 TGFB1
14 12.43 MAPK8 SMAD2 SMAD3 TGFB1
15
Show member pathways
12.43 BMP6 BMP7 CCN2 CDH1 HGF MAPK8
16 12.38 CDH1 SMAD2 SMAD3 TGFB1
17
Show member pathways
12.34 SERPINE1 SMAD2 SMAD3 SMAD7 TGFB1
18
Show member pathways
12.28 BMP6 BMP7 CCN2 HGF TGFB1
19 12.24 BMP6 BMP7 CCN2 SERPINE1 SMAD2 SMAD3
20
Show member pathways
12.23 MAPK8 SMAD2 SMAD3 TGFB1
21 12.2 CDH1 SMAD2 SMAD3 TGFB1
22 12.18 SERPINE1 SMAD2 SMAD3 TGFB1
23 12.12 MAPK8 SMAD2 SMAD3 SMAD7 TGFB1
24 12.12 BMP6 BMP7 MAPK8 SMAD2 SMAD3 TGFB1
25
Show member pathways
12.11 MAPK8 SMAD2 SMAD3 TGFB1
26 12.05 AGTR1 CCN2 CDH1 SERPINE1 SMAD2 SMAD3
27 12.01 CCL2 CD36 HGF TGFB1
28 11.96 MAPK8 SMAD2 SMAD3 SMAD7 TGFB1
29 11.9 CCL2 HGF REN TGFB1
30
Show member pathways
11.86 SMAD2 SMAD3 TGFB1
31
Show member pathways
11.85 AGTR1 NR3C2 REN TGFB1
32
Show member pathways
11.83 MAPK8 SMAD2 SMAD3 TGFB1
33 11.82 SERPINE1 SMAD2 SMAD3 SMAD7
34 11.81 BMP6 BMP7 SMAD2 SMAD3 SMAD7 TGFB1
35 11.8 AGTR1 CCL2 MAPK8 SERPINE1 SMAD2 SMAD3
36 11.8 BMP6 BMP7 CCN2 CDH1 SERPINE1 SMAD2
37 11.79 SERPINE1 SMAD2 SMAD3 SMAD7 TGFB1
38
Show member pathways
11.77 SMAD2 SMAD3 SMAD7 TGFB1
39 11.76 BMP6 BMP7 MAPK8 SMAD2 SMAD3 TGFB1
40 11.75 CDH1 SMAD2 SMAD3
41
Show member pathways
11.75 BMP6 BMP7 SMAD7
42 11.75 BMP6 BMP7 CCN2 HGF TGFB1
43 11.73 CCL2 CD36 TGFB1
44 11.7 MAPK8 SMAD2 SMAD3
45 11.69 BMP6 BMP7 TGFB1
46 11.66 SERPINE1 SMAD2 SMAD3 SMAD7 TGFB1
47
Show member pathways
11.65 MAPK8 SMAD2 SMAD3 TGFB1
48 11.6 CCL2 CD36 HGF TGFB1
49 11.6 BMP7 CCL2 CCN2 HGF SMAD7 TGFB1
50 11.57 MAPK8 SMAD3 TGFB1

GO Terms for Renal Fibrosis

Cellular components related to Renal Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.76 AGTR1 CCL2 CD36 MAPK8 REN SMAD2
2 extracellular space GO:0005615 9.61 BMP6 BMP7 CCL2 CCN2 CD36 HGF
3 platelet alpha granule lumen GO:0031093 9.5 HGF SERPINE1 TGFB1
4 SMAD protein complex GO:0071141 9.26 SMAD2 SMAD3
5 heteromeric SMAD protein complex GO:0071144 8.62 SMAD2 SMAD3
6 extracellular region GO:0005576 10.02 BMP6 BMP7 CCL2 CCN2 CDH1 HGF

Biological processes related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.95 CCL2 CD36 MAPK8 SERPINE1
2 platelet degranulation GO:0002576 9.92 CD36 HGF SERPINE1 TGFB1
3 wound healing GO:0042060 9.91 SMAD2 SMAD3 TGFB1
4 response to organic substance GO:0010033 9.9 CDH1 REN TGFB1
5 ossification GO:0001503 9.9 BMP6 BMP7 CCN2
6 kidney development GO:0001822 9.9 AGTR1 BMP6 BMP7 REN
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.89 CD36 HGF TGFB1
8 cell chemotaxis GO:0060326 9.89 AGTR1 CCL2 HGF
9 BMP signaling pathway GO:0030509 9.88 BMP6 BMP7 SMAD7
10 cellular response to mechanical stimulus GO:0071260 9.88 BMP6 MAPK8 TGFB1
11 response to glucose GO:0009749 9.86 CCN2 SMAD2 TGFB1
12 transforming growth factor beta receptor signaling pathway GO:0007179 9.86 SMAD2 SMAD3 SMAD7 TGFB1
13 cellular response to transforming growth factor beta stimulus GO:0071560 9.85 SMAD3 SMAD7 TGFB1
14 cell development GO:0048468 9.84 BMP6 BMP7 TGFB1
15 positive regulation of osteoblast differentiation GO:0045669 9.84 BMP6 BMP7 HGF
16 positive regulation of stress fiber assembly GO:0051496 9.83 CCN2 RGCC SMAD3
17 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.83 SMAD2 SMAD3 SMAD7 TGFB1
18 positive regulation of cell death GO:0010942 9.82 BMP7 CCN2 CD36
19 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.81 BMP6 BMP7 TGFB1
20 regulation of MAPK cascade GO:0043408 9.81 BMP6 BMP7 REN TGFB1
21 epithelial to mesenchymal transition GO:0001837 9.8 BMP7 HGF TGFB1
22 mesoderm formation GO:0001707 9.79 BMP7 SMAD2 SMAD3
23 positive regulation of protein import into nucleus GO:0042307 9.78 CDH1 SMAD3 TGFB1
24 endoderm development GO:0007492 9.77 SMAD2 SMAD3 TGFB1
25 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.76 BMP7 SPHK1 TGFB1
26 positive regulation of gene expression GO:0010628 9.76 BMP7 CCN2 CD36 MAPK8 RGCC SMAD2
27 negative regulation of cell-cell adhesion GO:0022408 9.73 CDH1 TGFB1
28 positive regulation of DNA biosynthetic process GO:2000573 9.73 HGF RGCC
29 negative regulation of wound healing GO:0061045 9.73 SERPINE1 SMAD3
30 positive regulation of bone mineralization GO:0030501 9.73 BMP6 BMP7 SMAD3 TGFB1
31 lens fiber cell differentiation GO:0070306 9.72 SMAD3 TGFB1
32 mesonephros development GO:0001823 9.72 BMP7 REN
33 pathway-restricted SMAD protein phosphorylation GO:0060389 9.72 SMAD7 TGFB1
34 positive regulation of blood coagulation GO:0030194 9.72 CD36 SERPINE1
35 positive regulation of collagen biosynthetic process GO:0032967 9.72 CCN2 RGCC TGFB1
36 positive regulation of SMAD protein signal transduction GO:0060391 9.71 BMP6 TGFB1
37 embryonic pattern specification GO:0009880 9.71 BMP7 SMAD2 SMAD3
38 nodal signaling pathway GO:0038092 9.7 SMAD2 SMAD3
39 primary miRNA processing GO:0031053 9.7 SMAD2 SMAD3
40 response to cholesterol GO:0070723 9.69 SMAD2 TGFB1
41 salivary gland morphogenesis GO:0007435 9.69 BMP7 TGFB1
42 embryonic foregut morphogenesis GO:0048617 9.68 SMAD2 SMAD3
43 pericardium development GO:0060039 9.68 SMAD2 SMAD3
44 response to laminar fluid shear stress GO:0034616 9.68 SMAD7 TGFB1
45 regulation of removal of superoxide radicals GO:2000121 9.66 BMP7 CD36
46 common-partner SMAD protein phosphorylation GO:0007182 9.65 SMAD2 TGFB1
47 SMAD protein signal transduction GO:0060395 9.65 BMP6 BMP7 SMAD2 SMAD3 TGFB1
48 regulation of striated muscle tissue development GO:0016202 9.63 SMAD3 TGFB1
49 renin-angiotensin regulation of aldosterone production GO:0002018 9.63 AGTR1 REN
50 SMAD protein complex assembly GO:0007183 9.63 SMAD2 SMAD3 TGFB1

Molecular functions related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 AGTR1 BMP7 CCL2 CCN2 CD36 CDH1
2 protein heterodimerization activity GO:0046982 9.85 AGTR1 BMP6 HGF SMAD2 SMAD3 TGFB1
3 cytokine activity GO:0005125 9.76 BMP6 BMP7 CCL2 TGFB1
4 beta-catenin binding GO:0008013 9.69 CDH1 SMAD3 SMAD7
5 growth factor activity GO:0008083 9.65 BMP6 BMP7 CCN2 HGF TGFB1
6 enhancer binding GO:0035326 9.54 SMAD2 SMAD3
7 co-SMAD binding GO:0070410 9.52 SMAD2 SMAD3
8 R-SMAD binding GO:0070412 9.5 RGCC SMAD2 SMAD3
9 I-SMAD binding GO:0070411 9.49 SMAD2 SMAD7
10 BMP receptor binding GO:0070700 9.48 BMP6 BMP7
11 primary miRNA binding GO:0070878 9.43 SMAD2 SMAD3
12 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.4 SMAD2 SMAD3
13 type I transforming growth factor beta receptor binding GO:0034713 9.33 SMAD2 SMAD7 TGFB1
14 transforming growth factor beta receptor binding GO:0005160 9.02 BMP6 BMP7 SMAD2 SMAD3 TGFB1

Sources for Renal Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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37 KEGG
38 LifeMap
40 LOVD
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44 MeSH
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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